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Volumn 27, Issue 11, 2010, Pages 2067-2076

Sustained expression of vascular endothelial growth factor and angiopoietin-1 improves blood-spinal cord barrier integrity and functional recovery after spinal cord injury

Author keywords

angiopoietin 1; magnetic resonance imaging; traumatic spinal cord injury; vascular endothelial growth factor; viral mediated transfection

Indexed keywords

ANGIOPOIETIN 1; VASCULOTROPIN; VIRUS VECTOR;

EID: 78649346412     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/neu.2010.1403     Document Type: Article
Times cited : (58)

References (62)
  • 1
    • 0037689525 scopus 로고    scopus 로고
    • Induction of functional neovascularization by combined VEGF and an-giopoietin-1 gene transfer using AAV vectors
    • Arsic, N., Zentilin, L., Zacchigna, S., Santoro, D., Stanta, G., Salvi, A., Sinagra, G., and Giacca, M. (2003). Induction of functional neovascularization by combined VEGF and an-giopoietin-1 gene transfer using AAV vectors. Mol. Ther. 7, 450-459.
    • (2003) Mol. Ther. , vol.7 , pp. 450-459
    • Arsic, N.1    Zentilin, L.2    Zacchigna, S.3    Santoro, D.4    Stanta, G.5    Salvi, A.6    Sinagra, G.7    Giacca, M.8
  • 2
    • 0028919411 scopus 로고
    • A sensitive and reliable locomotor rating scale for open field testing in rats
    • Basso, D.M., Beattie, M.S., and Bresnahan, J.C. (1995). A sensitive and reliable locomotor rating scale for open field testing in rats. J. Neurotrauma 12, 1-21.
    • (1995) J. Neurotrauma , vol.12 , pp. 1-21
    • Basso, D.M.1    Beattie, M.S.2    Bresnahan, J.C.3
  • 3
    • 33748317859 scopus 로고    scopus 로고
    • VEGF and angiopoietin-1 stimulate different angiogenic phenotypes that combine to enhance functional neovascularization in adult tissue
    • Benest, A.V., Salmon, A.H., Wang, W., Glover, C.P., Uney, J., Harper, S.J., and Bates, D.O. (2006). VEGF and angiopoietin-1 stimulate different angiogenic phenotypes that combine to enhance functional neovascularization in adult tissue. Micro-circulation 13, 423-437.
    • (2006) Micro-circulation , vol.13 , pp. 423-437
    • Benest, A.V.1    Salmon, A.H.2    Wang, W.3    Glover, C.P.4    Uney, J.5    Harper, S.J.6    Bates, D.O.7
  • 4
    • 0035093854 scopus 로고    scopus 로고
    • Dynamic contrast-enhanced MRI of experimental spinal cord injury: In vivo serial studies
    • Bilgen, M., Abbe, R., and Narayana, P.A. (2001). Dynamic contrast-enhanced MRI of experimental spinal cord injury: in vivo serial studies. Magn. Reson. Med. 45, 614-622.
    • (2001) Magn. Reson. Med. , vol.45 , pp. 614-622
    • Bilgen, M.1    Abbe, R.2    Narayana, P.A.3
  • 6
    • 0023158586 scopus 로고
    • A behavioral and anatomical analysis of spinal cord injury produced by a feedback-controlled impaction device
    • Bresnahan, J.C., Beattie, M.S., Todd, F.D., 3rd, and Noyes, D.H. (1987). A behavioral and anatomical analysis of spinal cord injury produced by a feedback-controlled impaction device. Exp. Neurol. 95, 548-570.
    • (1987) Exp. Neurol. , vol.95 , pp. 548-570
    • Bresnahan, J.C.1    Beattie, M.S.2    Todd III, F.D.3    Noyes, D.H.4
  • 7
  • 8
    • 33947630717 scopus 로고    scopus 로고
    • Adeno-associated virus vectors simultaneously encoding VEGF and angiopoietin-1 enhances neovascularization in is-chemic rabbit hind-limbs
    • Chen, F., Tan, Z., Dong, C.Y., Chen, X., and Guo, S.F. (2007a). Adeno-associated virus vectors simultaneously encoding VEGF and angiopoietin-1 enhances neovascularization in is-chemic rabbit hind-limbs. Acta Pharmacol. Sin. 28, 493-502.
    • (2007) Acta Pharmacol. Sin. , vol.28 , pp. 493-502
    • Chen, F.1    Tan, Z.2    Dong, C.Y.3    Chen, X.4    Guo, S.F.5
  • 9
    • 34250850774 scopus 로고    scopus 로고
    • Combination of VEGF(165)/Angiopoietin-1 gene and endothelial progenitor cells for therapeutic neo-vascularization
    • Chen, F., Tan, Z., Dong, C.Y., Li, X., Xie, Y., Wu, Y., Chen, X., and Guo, S. (2007b). Combination of VEGF(165)/Angiopoietin-1 gene and endothelial progenitor cells for therapeutic neo-vascularization. Eur. J. Pharmacol. 568, 222-230.
    • (2007) Eur. J. Pharmacol. , vol.568 , pp. 222-230
    • Chen, F.1    Tan, Z.2    Dong, C.Y.3    Li, X.4    Xie, Y.5    Wu, Y.6    Chen, X.7    Guo, S.8
  • 10
    • 64949107710 scopus 로고    scopus 로고
    • Blood-spinal cord barrier permeability in experimental spinal cord injury: Dynamic contrast-enhanced MRI
    • Cohen, D.M., Patel, C.B., Ahobila-Vajjula, P., Sundberg, L.M., Chacko, T., Liu, S.J., and Narayana, P.A. (2009). Blood-spinal cord barrier permeability in experimental spinal cord injury: dynamic contrast-enhanced MRI. NMR Biomed. 22, 332-341.
    • (2009) NMR Biomed. , vol.22 , pp. 332-341
    • Cohen, D.M.1    Patel, C.B.2    Ahobila-Vajjula, P.3    Sundberg, L.M.4    Chacko, T.5    Liu, S.J.6    Narayana, P.A.7
  • 11
    • 0034753860 scopus 로고    scopus 로고
    • Vascular growth factors in cerebral ischemia
    • Croll, S.D., and Wiegand, S.J. (2001). Vascular growth factors in cerebral ischemia. Mol. Neurobiol. 23, 121-135.
    • (2001) Mol. Neurobiol. , vol.23 , pp. 121-135
    • Croll, S.D.1    Wiegand, S.J.2
  • 14
    • 33645282243 scopus 로고    scopus 로고
    • In vivo serial diffusion tensor imaging of experimental spinal cord injury
    • Deo, A.A., Grill, R.J., Hasan, K.M., and Narayana, P.A. (2006). In vivo serial diffusion tensor imaging of experimental spinal cord injury. J. Neurosci. Res. 83, 801-810.
    • (2006) J. Neurosci. Res. , vol.83 , pp. 801-810
    • Deo, A.A.1    Grill, R.J.2    Hasan, K.M.3    Narayana, P.A.4
  • 15
    • 0024316705 scopus 로고
    • The relationships among the severity of spinal cord injury, motor and somatosensory evoked potentials and spinal cord blood flow
    • Fehlings, M.G., Tator, C.H., and Linden, R.D. (1989). The relationships among the severity of spinal cord injury, motor and somatosensory evoked potentials and spinal cord blood flow. Electroencephalogr. Clin. Neurophysiol. 74, 241-259.
    • (1989) Electroencephalogr. Clin. Neurophysiol. , vol.74 , pp. 241-259
    • Fehlings, M.G.1    Tator, C.H.2    Linden, R.D.3
  • 16
    • 0032418513 scopus 로고    scopus 로고
    • In vivo echo-planar imaging of rat spinal cord
    • Fenyes, D.A., and Narayana, P.A. (1998). In vivo echo-planar imaging of rat spinal cord. Magn. Reson. Imaging 16, 1249-1255.
    • (1998) Magn. Reson. Imaging , vol.16 , pp. 1249-1255
    • Fenyes, D.A.1    Narayana, P.A.2
  • 17
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara, N., Gerber, H.P., and LeCouter, J. (2003). The biology of VEGF and its receptors. Nat. Med. 9, 669-676.
    • (2003) Nat. Med. , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    Lecouter, J.3
  • 18
    • 36348946298 scopus 로고    scopus 로고
    • VEGF induces Tie2 shedding via a phosphoinositide 3-kinase/Akt dependent pathway to modulate Tie2 signaling
    • Findley, C.M., Cudmore, M.J., Ahmed, A., and Kontos, C.D. (2007). VEGF induces Tie2 shedding via a phosphoinositide 3-kinase/Akt dependent pathway to modulate Tie2 signaling. Arterioscler. Thromb. Vasc. Biol. 27, 2619-2626.
    • (2007) Arterioscler. Thromb. Vasc. Biol. , vol.27 , pp. 2619-2626
    • Findley, C.M.1    Cudmore, M.J.2    Ahmed, A.3    Kontos, C.D.4
  • 20
    • 30744477950 scopus 로고    scopus 로고
    • From angiogenesis to neu-ropathology
    • Greenberg, D.A., and Jin, K. (2005). From angiogenesis to neu-ropathology. Nature 438, 954-959.
    • (2005) Nature , vol.438 , pp. 954-959
    • Greenberg, D.A.1    Jin, K.2
  • 22
    • 0037266459 scopus 로고    scopus 로고
    • Effects of intraventricular infusion of vascular endothelial growth factor on cerebral blood flow, edema, and infarct volume
    • Harrigan, M.R., Ennis, S.R., Sullivan, S.E., and Keep, R.F. (2003). Effects of intraventricular infusion of vascular endothelial growth factor on cerebral blood flow, edema, and infarct volume. Acta Neurochir. (Wien.) 145, 49-53.
    • (2003) Acta Neurochir. (Wien.) , vol.145 , pp. 49-53
    • Harrigan, M.R.1    Ennis, S.R.2    Sullivan, S.E.3    Keep, R.F.4
  • 23
    • 0038340422 scopus 로고    scopus 로고
    • Post-traumatic inflammation following spinal cord injury
    • Hausmann, O.N. (2003). Post-traumatic inflammation following spinal cord injury. Spinal Cord 41, 369-378.
    • (2003) Spinal Cord , vol.41 , pp. 369-378
    • Hausmann, O.N.1
  • 24
    • 0031826273 scopus 로고    scopus 로고
    • Reduction of is-chemic damage by application of vascular endothelial growth factor in rat brain after transient ischemia
    • Hayashi, T., Abe, K., and Itoyama, Y. (1998). Reduction of is-chemic damage by application of vascular endothelial growth factor in rat brain after transient ischemia. J. Cereb. Blood Flow Metab. 18, 887-895.
    • (1998) J. Cereb. Blood Flow Metab. , vol.18 , pp. 887-895
    • Hayashi, T.1    Abe, K.2    Itoyama, Y.3
  • 25
    • 0031802635 scopus 로고    scopus 로고
    • Viral vectors, tools for gene transfer in the nervous system
    • Hermens, W.T., and Verhaagen, J. (1998). Viral vectors, tools for gene transfer in the nervous system. Prog. Neurobiol. 55, 399-432.
    • (1998) Prog. Neurobiol. , vol.55 , pp. 399-432
    • Hermens, W.T.1    Verhaagen, J.2
  • 26
    • 69249108768 scopus 로고    scopus 로고
    • Reduced vascular endothelial growth factor expression in contusive spinal cord injury
    • Herrera, J.J., Nesic-Taylor, D.O., and Narayana, P.A. (2009). Reduced vascular endothelial growth factor expression in contusive spinal cord injury. J. Neurotrauma 26, 995-1003.
    • (2009) J. Neurotrauma , vol.26 , pp. 995-1003
    • Herrera, J.J.1    Nesic-Taylor, D.O.2    Narayana, P.A.3
  • 27
    • 0025358181 scopus 로고
    • Relation between spinal cord blood flow and functional recovery after blocking weight-induced spinal cord injury in rats
    • Holtz, A., Nystrom, B., and Gerdin, B. (1990). Relation between spinal cord blood flow and functional recovery after blocking weight-induced spinal cord injury in rats. Neurosurgery 26, 952-957.
    • (1990) Neurosurgery , vol.26 , pp. 952-957
    • Holtz, A.1    Nystrom, B.2    Gerdin, B.3
  • 28
    • 1942455227 scopus 로고    scopus 로고
    • A pericyte-derived angiopoietin-1 multimeric complex induces occludin gene expression in brain capillary en-dothelial cells through Tie-2 activation in vitro
    • Hori, S., Ohtsuki, S., Hosoya, K., Nakashima, E., Terasaki, T. (2004). A pericyte-derived angiopoietin-1 multimeric complex induces occludin gene expression in brain capillary en-dothelial cells through Tie-2 activation in vitro. J. Neurochem. 89, 503-513.
    • (2004) J. Neurochem. , vol.89 , pp. 503-513
    • Hori, S.1    Ohtsuki, S.2    Hosoya, K.3    Nakashima, E.4    Terasaki, T.5
  • 29
    • 24944471398 scopus 로고    scopus 로고
    • VEGF protects brain against focal ischemia without increasing blood-brain permeability when administered intracerebroventricularly
    • Kaya, D., Gursoy-Ozdemir, Y., Yemisci, M., Tuncer, N., Aktan, S., and Dalkara, T. (2005). VEGF protects brain against focal ischemia without increasing blood-brain permeability when administered intracerebroventricularly. J. Cereb. Blood Flow Metab. 25, 1111-1118.
    • (2005) J. Cereb. Blood Flow Metab. , vol.25 , pp. 1111-1118
    • Kaya, D.1    Gursoy-Ozdemir, Y.2    Yemisci, M.3    Tuncer, N.4    Aktan, S.5    Dalkara, T.6
  • 31
    • 64749111597 scopus 로고    scopus 로고
    • Angiopoietin-1 reduces vascular endothelial growth factor-induced brain endothelial permeability via upregula-tion of ZO-2
    • Lee, S.W., Kim, W.J., Jun, H.O., Choi, Y.K., and Kim, K.W. (2009). Angiopoietin-1 reduces vascular endothelial growth factor-induced brain endothelial permeability via upregula-tion of ZO-2. Int. J. Mol. Med. 23, 279-284.
    • (2009) Int. J. Mol. Med. , vol.23 , pp. 279-284
    • Lee, S.W.1    Kim, W.J.2    Jun, H.O.3    Choi, Y.K.4    Kim, K.W.5
  • 32
    • 0033966614 scopus 로고    scopus 로고
    • Induction of angiopoietin and Tie receptor mRNA expression after cerebral ischemia-reperfusion
    • Lin, T.N., Wang, C.K., Cheung, W.M., and Hsu, C.Y. (2000). Induction of angiopoietin and Tie receptor mRNA expression after cerebral ischemia-reperfusion. J. Cereb. Blood Flow Metab. 20, 387-395.
    • (2000) J. Cereb. Blood Flow Metab. , vol.20 , pp. 387-395
    • Lin, T.N.1    Wang, C.K.2    Cheung, W.M.3    Hsu, C.Y.4
  • 33
    • 73049117998 scopus 로고    scopus 로고
    • An engineered transcription factor which activates VEGF-A enhances recovery after spinal cord injury
    • Liu, Y., Figley, S., Spratt, S.K., Lee, G., Ando, D., Surosky, R., and Fehlings, M.G. (2010). An engineered transcription factor which activates VEGF-A enhances recovery after spinal cord injury. Neurobiol. Dis. 37, 384-393.
    • (2010) Neurobiol. Dis. , vol.37 , pp. 384-393
    • Liu, Y.1    Figley, S.2    Spratt, S.K.3    Lee, G.4    Ando, D.5    Surosky, R.6    Fehlings, M.G.7
  • 34
    • 0021049458 scopus 로고
    • Neuronophagia by leukocytes in experimental spinal cord injury
    • Means, E.D., and Anderson, D.K. (1983). Neuronophagia by leukocytes in experimental spinal cord injury. J. Neuropathol. Exp. Neurol. 42, 707-719.
    • (1983) J. Neuropathol. Exp. Neurol. , vol.42 , pp. 707-719
    • Means, E.D.1    Anderson, D.K.2
  • 35
    • 0034781793 scopus 로고    scopus 로고
    • Changes in exploratory behavior as a measure of chronic central pain following spinal cord injury
    • Mills, C.D., Grady, J.J., and Hulsebosch, C.E. (2001). Changes in exploratory behavior as a measure of chronic central pain following spinal cord injury. J. Neurotrauma 18, 1091-1105.
    • (2001) J. Neurotrauma , vol.18 , pp. 1091-1105
    • Mills, C.D.1    Grady, J.J.2    Hulsebosch, C.E.3
  • 36
    • 0032907687 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) and its receptors
    • Neufeld, G., Cohen, T., Gengrinovitch, S., and Poltorak, Z. (1999). Vascular endothelial growth factor (VEGF) and its receptors. FASEB J. 13, 9-22.
    • (1999) FASEB J. , vol.13 , pp. 9-22
    • Neufeld, G.1    Cohen, T.2    Gengrinovitch, S.3    Poltorak, Z.4
  • 37
    • 0041970282 scopus 로고    scopus 로고
    • Altered expression of angiopoietins during blood-brain barrier breakdown and angiogenesis
    • Nourhaghighi, N., Teichert-Kuliszewska, K., Davis, J., Stewart, D.J., and Nag, S. (2003). Altered expression of angiopoietins during blood-brain barrier breakdown and angiogenesis. Lab. Invest. 83, 1211-1222.
    • (2003) Lab. Invest. , vol.83 , pp. 1211-1222
    • Nourhaghighi, N.1    Teichert-Kuliszewska, K.2    Davis, J.3    Stewart, D.J.4    Nag, S.5
  • 38
    • 69249150412 scopus 로고    scopus 로고
    • Effect of VEGF Treatment on the blood-spinal cord barrier permeability in experimental spinal cord injury: Dynamic contrast-enhanced magnetic resonance imaging
    • Patel, C.B., Cohen, D.M., Ahobila-Vajjula, P., Sundberg, L.M., Chacko, T., and Narayana, P.A. (2009). Effect of VEGF Treatment on the blood-spinal cord barrier permeability in experimental spinal cord injury: Dynamic contrast-enhanced magnetic resonance imaging. J. Neurotrauma 26, 1005-1016.
    • (2009) J. Neurotrauma , vol.26 , pp. 1005-1016
    • Patel, C.B.1    Cohen, D.M.2    Ahobila-Vajjula, P.3    Sundberg, L.M.4    Chacko, T.5    Narayana, P.A.6
  • 39
    • 33646379090 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha contributes to below-level neuropathic pain after spinal cord injury
    • Peng, X.M., Zhou, Z.G., Glorioso, J.C., Fink, D.J., and Mata, M. (2006). Tumor necrosis factor-alpha contributes to below-level neuropathic pain after spinal cord injury. Ann. Neurol. 59, 843-851.
    • (2006) Ann. Neurol. , vol.59 , pp. 843-851
    • Peng, X.M.1    Zhou, Z.G.2    Glorioso, J.C.3    Fink, D.J.4    Mata, M.5
  • 40
    • 0037216605 scopus 로고    scopus 로고
    • Manipulating neuroin-flammatory reactions in the injured spinal cord: Back to basics
    • Popovich, P.G., and Jones, T.B. (2003). Manipulating neuroin-flammatory reactions in the injured spinal cord: back to basics. Trends Pharmacol. Sci. 24, 13-17.
    • (2003) Trends Pharmacol. Sci. , vol.24 , pp. 13-17
    • Popovich, P.G.1    Jones, T.B.2
  • 41
    • 0036794017 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is expressed in multiple sclerosis plaques and can induce inflammatory lesions in experimental allergic encephalomyelitis rats
    • Proescholdt, M.A., Jacobson, S., Tresser, N., Oldfield, E.H., and Merrill, M.J. (2002). Vascular endothelial growth factor is expressed in multiple sclerosis plaques and can induce inflammatory lesions in experimental allergic encephalomyelitis rats. J. Neuropathol. Exp. Neurol. 61, 914-925.
    • (2002) J. Neuropathol. Exp. Neurol. , vol.61 , pp. 914-925
    • Proescholdt, M.A.1    Jacobson, S.2    Tresser, N.3    Oldfield, E.H.4    Merrill, M.J.5
  • 42
    • 0017650830 scopus 로고
    • Objective clinical assessment of motor function after experimental spinal cord injury in the rat
    • Rivlin, A.S., and Tator, C.H. (1977). Objective clinical assessment of motor function after experimental spinal cord injury in the rat. J. Neurosurg. 47, 577-581.
    • (1977) J. Neurosurg. , vol.47 , pp. 577-581
    • Rivlin, A.S.1    Tator, C.H.2
  • 43
    • 0344375091 scopus 로고    scopus 로고
    • Experimental modeling of spinal cord injury: Characterization of a force-defined injury device
    • Scheff, S.W., Rabchevsky, A.G., Fugaccia, I., Main, J.A., and Lumpp, J.E, Jr. (2003). Experimental modeling of spinal cord injury: characterization of a force-defined injury device. J. Neurotrauma 20, 179-193.
    • (2003) J. Neurotrauma , vol.20 , pp. 179-193
    • Scheff, S.W.1    Rabchevsky, A.G.2    Fugaccia, I.3    Main, J.A.4    Lumpp Jr., J.E.5
  • 44
    • 0036797791 scopus 로고    scopus 로고
    • A statistical method for analyzing rating scale data: The BBB locomotor score
    • Scheff, S.W., Saucier, D.A., and Cain, M.E. (2002). A statistical method for analyzing rating scale data: the BBB locomotor score. J. Neurotrauma 19, 1251-1260.
    • (2002) J. Neurotrauma , vol.19 , pp. 1251-1260
    • Scheff, S.W.1    Saucier, D.A.2    Cain, M.E.3
  • 45
    • 0032821690 scopus 로고    scopus 로고
    • Acute inflammatory responses to mechanical lesions in the CNS: Differences between brain and spinal cord
    • Schnell, L., Fearn, S., Klassen, H., Schwab, M.E., and Perry, V.H. (1999). Acute inflammatory responses to mechanical lesions in the CNS: differences between brain and spinal cord. Eur. J. Neurosci. 11, 3648-3658.
    • (1999) Eur. J. Neurosci. , vol.11 , pp. 3648-3658
    • Schnell, L.1    Fearn, S.2    Klassen, H.3    Schwab, M.E.4    Perry, V.H.5
  • 46
    • 0030671462 scopus 로고    scopus 로고
    • Efficient and stable adeno-associated virus-mediated transduction in the skeletal muscle of adult immunocompetent mice
    • Snyder, R.O., Spratt, S.K., Lagarde, C., Bohl, D., Kaspar, B., Sloan, B., Cohen, L.K., and Danos, O. (1997). Efficient and stable adeno-associated virus-mediated transduction in the skeletal muscle of adult immunocompetent mice. Hum. Gene Ther. 8, 1891-1900.
    • (1997) Hum. Gene Ther. , vol.8 , pp. 1891-1900
    • Snyder, R.O.1    Spratt, S.K.2    Lagarde, C.3    Bohl, D.4    Kaspar, B.5    Sloan, B.6    Cohen, L.K.7    Danos, O.8
  • 47
    • 76249110720 scopus 로고    scopus 로고
    • CD8 T cell-initiated vascular endothelial growth factor expression promotes central nervous system vascular permeability under neuroinflammatory conditions
    • Suidan, G.L., Dickerson, J.W., Chen, Y., McDole, J.R., Tripathi, P., Pirko, I., Seroogy, K.B., and Johnson, A.J. (2010). CD8 T cell-initiated vascular endothelial growth factor expression promotes central nervous system vascular permeability under neuroinflammatory conditions. J. Immunol. 184, 1031-1040.
    • (2010) J. Immunol. , Issue.184 , pp. 1031-1040
    • Suidan, G.L.1    Dickerson, J.W.2    Chen, Y.3    McDole, J.R.4    Tripathi, P.5    Pirko, I.6    Seroogy, K.B.7    Johnson, A.J.8
  • 48
    • 0041743159 scopus 로고    scopus 로고
    • VEGF-induced neuroprotection, neu-rogenesis, and angiogenesis after focal cerebral ischemia
    • Sun, Y., Jin, K., Xie, L., Childs, J., Mao, X.O., Logvinova, A., and Greenberg, D.A. (2003). VEGF-induced neuroprotection, neu-rogenesis, and angiogenesis after focal cerebral ischemia. J. Clin. Invest. 111, 1843-1851.
    • (2003) J. Clin. Invest. , vol.111 , pp. 1843-1851
    • Sun, Y.1    Jin, K.2    Xie, L.3    Childs, J.4    Mao, X.O.5    Logvinova, A.6    Greenberg, D.A.7
  • 50
    • 0032902054 scopus 로고    scopus 로고
    • Efficient and stable trans-duction of cardiomyocytes after intramyocardial injection or intracoronary perfusion with recombinant adeno-associated virus vectors
    • Svensson, E.C., Marshall, D.J., Woodard, K., Lin, H., Jiang, F., Chu, L., and Leiden, J.M. (1999). Efficient and stable trans-duction of cardiomyocytes after intramyocardial injection or intracoronary perfusion with recombinant adeno-associated virus vectors. Circulation 99, 201-205.
    • (1999) Circulation , vol.99 , pp. 201-205
    • Svensson, E.C.1    Marshall, D.J.2    Woodard, K.3    Lin, H.4    Jiang, F.5    Chu, L.6    Leiden, J.M.7
  • 51
    • 0034063626 scopus 로고    scopus 로고
    • Role of leukocytes in spinal cord injury in rats
    • Taoka, Y., and Okajima, K. (2000). Role of leukocytes in spinal cord injury in rats. J. Neurotrauma 17, 219-229.
    • (2000) J. Neurotrauma , vol.17 , pp. 219-229
    • Taoka, Y.1    Okajima, K.2
  • 52
    • 0026326449 scopus 로고
    • Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms
    • Tator, C.H., and Fehlings, M.G. (1991). Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms. J. Neurosurg. 75, 15-26.
    • (1991) J. Neurosurg. , vol.75 , pp. 15-26
    • Tator, C.H.1    Fehlings, M.G.2
  • 53
    • 0025986461 scopus 로고
    • Review of experimental spinal cord injury with emphasis on the local and systemic circulatory effects
    • Tator, C.H. (1991). Review of experimental spinal cord injury with emphasis on the local and systemic circulatory effects. Neurochirurgie 37, 291-302.
    • (1991) Neurochirurgie , vol.37 , pp. 291-302
    • Tator, C.H.1
  • 55
  • 58
    • 0042133340 scopus 로고    scopus 로고
    • Vascular endothelial growth factor improves functional outcome and decreases secondary degeneration in experimental spinal cord contusion injury
    • Widenfalk, J., Lipson, A., Jubran, M., Hofstetter, C., Ebendal, T., Cao, Y., and Olson, L. (2003). Vascular endothelial growth factor improves functional outcome and decreases secondary degeneration in experimental spinal cord contusion injury. Neuroscience 120, 951-960.
    • (2003) Neuroscience , vol.120 , pp. 951-960
    • Widenfalk, J.1    Lipson, A.2    Jubran, M.3    Hofstetter, C.4    Ebendal, T.5    Cao, Y.6    Olson, L.7
  • 60
    • 0037008879 scopus 로고    scopus 로고
    • Angiopoietin-1 reduces cerebral blood vessel leakage and is-chemic lesion volume after focal cerebral embolic ischemia in mice
    • Zhang, Z.G., Zhang, L., Croll, S.D., and Chopp, M. (2002a). Angiopoietin-1 reduces cerebral blood vessel leakage and is-chemic lesion volume after focal cerebral embolic ischemia in mice. Neuroscience 113, 683-687.
    • (2002) Neuroscience , vol.113 , pp. 683-687
    • Zhang, Z.G.1    Zhang, L.2    Croll, S.D.3    Chopp, M.4
  • 62
    • 77955635526 scopus 로고    scopus 로고
    • Angiopoietin 1 counteracts vascular endothelial growth factor-induced blood-brain barrier permeability and alleviates ischemic injury in the early stages of transient focal cerebral ischemia in rats
    • Zhao, Y., Li, Z., Wang, R., Wei, J., Li, G., and Zhao, H. (2009). Angiopoietin 1 counteracts vascular endothelial growth factor-induced blood-brain barrier permeability and alleviates ischemic injury in the early stages of transient focal cerebral ischemia in rats. Neurol. Res. 32, 748-755.
    • (2009) Neurol. Res. , vol.32 , pp. 748-755
    • Zhao, Y.1    Li, Z.2    Wang, R.3    Wei, J.4    Li, G.5    Zhao, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.