Transient Blockade of the CD11d/CD18 Integrin Reduces Secondary Damage after Spinal Cord Injury, Improving Sensory, Autonomic, and Motor Function

Journal of Neuroscience

Volumn 24, Issue 16, 2004, Pages 4043-4051

  Gris, Denis ^a,b   Marsh, Daniel R ^a,c   Oatway, Mark A ^a,b   Chen, Yuhua ^a   Hamilton, Eilis F ^a   Dekaban, Gregory A ^a,b   Weaver, Lynne C ^a,b  

^a ROBARTS RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Autonomic; Inflammation; Integrin; Locomotor; Myelin; Neurofilament; Pain; Spinal cord injury

Indexed keywords

CD11 ANTIGEN; CD18 ANTIGEN; INTEGRIN; MONOCLONAL ANTIBODY; MYELIN;

ANIMAL BEHAVIOR; ANIMAL MODEL; ARTICLE; AUTONOMIC DYSFUNCTION; AUTONOMIC DYSREFLEXIA; AUTONOMIC NERVOUS SYSTEM FUNCTION; CONTROLLED STUDY; INFLAMMATORY CELL; INFLAMMATORY INFILTRATE; LOCOMOTION; NEUROFILAMENT; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORIMOTOR FUNCTION; SPINAL CORD INJURY; SPINAL CORD ISCHEMIA; THORACIC SPINAL CORD;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD18; AUTONOMIC DYSREFLEXIA; DISEASE MODELS, ANIMAL; FEMALE; MALE; MOTOR ACTIVITY; MYELIN SHEATH; NEUROFILAMENT PROTEINS; RATS; RATS, WISTAR; RECOVERY OF FUNCTION; SPINAL CORD; SPINAL CORD INJURIES;

EID: 2142821430     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5343-03.2004     Document Type: Article

References (55)

1. Bao F, Chen Y, Dekaban G, Weaver LC (2004) Early anti-inflammatory treatment reduces lipid peroxidation and protein nitration after spinal cord injury in rats. J Neurochem 88:1335-1344.
2. Barbeau H, Mccrea DA, O'Donovan MJ, Rossignol S, Grill WM, Lemay MA (1999) Tapping into spinal circuits to restore motor function. Brain Res Brain Res Rev 30:27-51.
3. Basso DM, Beattie MS, Bresnahan JC (1995) A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 12:1-21.
4. Bethea JR, Dietrich WD (2002) Targeting the host inflammatory response in traumatic spinal cord injury. Curr Opin Neurol 15:355-360.
5. Bevilacqua MP (1993) Endothelial-leukocyte adhesion molecules. Annu Rev Immunol 11:767-804.
6. Blight AR (1985) Delayed demyelination and macrophage invasion: a candidate for "secondary" cell damage in spinal cord injury. CNS Trauma 2:299-315.
7. Bruce JC, Oatway MA, Weaver LC (2002) Chronic pain after clip compression injury of the rat spinal cord. Exp Neurol 178:33-48.
8. Christensen MD, Hulsebosch CE (1997) Chronic central pain after spinal cord injury. J Neurotrauma 14:517-537.
9. Christensen MD, Everhart AW, Pickelman JT, Hulsebosch CE (1996) Mechanical and thermal allodynia in chronic central pain following spinal cord injury. Pain 68:97-107.
10. Coumans JV, Lin TT, Dai HN, MacArthur L, McAtee M, Nash C, Bregman BS (2001) Axonal regeneration and functional recovery after complete spinal cord transection in rats by delayed treatment with transplants and neurotrophins. J Neurosci 21:9334-9344.
11. Dembowsky K, Czachurski J, Amendt K, Seller H (1980) Tonic descending inhibition of the spinal somato-sympathetic reflex from the lower brain stem. J Auton Nerv Syst 2:157-182.
12. Farooque M, Isaksson J, Olsson Y (1999) Improved recovery after spinal cord trauma in ICAM-1 and P-selectin knockout mice. NeuroReport 10:131-134.
13. Fields HL, Heinricher MM, Mason P (1991) Neurotransmitters in nociceptive modulatory circuits. Annu Rev Neurosci 14:219-245.
14. Grayson MH, Van der Vieren M, Sterbinsky SA, Gallantin WM, Hoffman P, Staunton D, Bochner BS (1999) alphadbeta2 integrin is a ligand for vascular cell adhesion molecule-1. Int Arch Allergy Immunol 118:263-264.
15. Grevel J (1992) Optimisation of immunosuppressive therapy using pharmacokinetic principles. Clin Pharmacokinet 23:380-390.
16. Hains BC, Yucra JA, Eaton MJ, Hulsebosch CE (2002) Intralesion transplantation of serotonergic precursors enhances locomotor recovery but has no effect on development of chronic central pain following hemisection injury in rats. Neurosci Lett 324:222-226.
17. Hall ED (1992) The neuroprotectivc pharmacology of methylprednisolone. J Neurol 76:13-22.
18. Hamada Y, Ikata T, Katoh S, Kauchi K, Wa M, Wai Y, Kuzawa K (1996) Involvement of an intercellular adhesion molecule 1-dependent pathway in the pathogenesis of secondary changes after spinal cord injury in rats. J Neurochem 66:1525-1531.
19. Hauben E, Nevo U, Yoles E, Moalem G, Agranov E, Mor F, Akselrod S, Neeman M, Cohen IR, Schwartz M (2000) Autoimmune T cells as potential neuroprotective therapy for spinal cord injury. Lancet 355:286-287.
20. Hurlbert RJ (2000) Methylprednisolone for acute spinal cord injury: an inappropriate standard of care. J Neurosurg 93:1-7.
21. Jones LL, Yamaguchi Y, Stallcup WB, Tuszynski MH (2002) NG2 is a major chondroitin sulfate proteoglycan produced after spinal cord injury and is expressed by macrophages and oligodendrocyte progenitors. J Neurosci 22:2792-2803.
22. Karlsson A-K (1999) Autonomic dysreflexia. Spinal Cord 37:383-391.
23. Kotter MR, Setzu A, Sim FJ, Van Rooijen N, Franklin RJ (2001) Macrophage depletion impairs oligodendrocyte remyelination following lysolecithin-induced demyelination. Glia 35:204-212.
24. Kunkel-Bagden E, Dai HN, Bregman BS (1993) Methods to assess the development and recovery of locomotor function after spinal cord injury in rats. Exp Neurol 119:153-164.
25. Kwon BK, Liu J, Messerer C, Kobayashi NR, McGraw J, Oschipok L, Tetzlaff W (2002) Survival and regeneration of rubrospinal neurons 1 year after spinal cord injury. Proc Natl Acad Sci USA 99:3246-3251.
26. Leskovar A, Moriarty LJ, Turek JJ, Schoenlein IA, Borgens RB (2000) The macrophage in acute neural injury: changes in cell numbers over time and levels of cytokine production in mammalian central and peripheral nervous systems. J Exp Biol 203 Pt 12:1783-1795.
27. Mabon PJ, Weaver LC, Dekaban GA (2000) Inhibition of monocyte/macrophage migration to a spinal cord injury site by an antibody to the integrin alphaD: a potential new anti-inflammatory treatment. Exp Neurol 166:52-64.
28. Maiorov DN, Krenz NR, Krassioukov AV, Weaver LC (1997) Role of spinal NMDA and AMPA receptors in episodic hypertension in conscious spinal rats. Am J Physiol 273:H1266-H1274.
29. Marsh DR, Weaver LC (2004) Autonomic dysreflexia, induced by noxious or innocuous stimulation, does not depend on changes in dorsal horn substance P. J Neurotrauma, in press.
30. Mathias CJ, Frankel HL (1992) Autonomic disturbances in spinal cord lesions. In: Autonomic failure. A textbook of clinical disorders of the autonomic nervous system (Mathias CJ, Bannister R, eds), pp 494-513. Oxford: Oxford UP.
31. McDonald JW, Liu XZ, Qu Y, Liu S, Mickey SK, Turetsky D, Gottlieb DI, Choi DW (1999) Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord. Nat Med 5:1410-1412.
32. Neish AS, Read MA, Thanos D, Pine R, Maniatis T, Collins T (1995) Endothelial interferon regulatory factor 1 cooperates with NF-kappa B as a transcriptional activator of vascular cell adhesion molecule 1. Mol Cell Biol 15:2558-2569.
33. Page KM (1965) A stain for myelin using solochrome cyanin. J Med Lab Tech 22:224.
34. Popovich PG, Hickey WF (2001) Bone marrow chimeric rats reveal the unique distribution of resident and recruited macrophages in the contused rat spinal cord. J Neuropathol Exp Neurol 60:676-685.
35. Popovich PG, Wei P, Stokes BT (1997) Cellular inflammatory response after spinal cord injury in Sprague-Dawley and Lewis rats. J Comp Neurol 377:443-464.
36. Popovich PG, Guan Z, Wei P, Huitinga I, van RN, Stokes BT (1999) Depletion of hematogenous macrophages promotes partial hindlimb recovery and neuroanatomical repair after experimental spinal cord injury. Exp Neurol 158:351-365.
37. Rabchevsky AG, Fugaccia I, Sullivan PG, Blades DA, Scheff SW (2002) Efficacy of methylprednisolone therapy for the injured rat spinal cord. J Neurosci Res 68:7-18.
38. Rapalino O, Lazarov-Spiegler O, Agranov E, Velan GJ, Yoles E, Fraidakis M, Solomon A, Gepstein R, Katz A, Belkin M, Hadani M, Schwartz M (1998) Implantation of stimulated homologous macrophages results in partial recovery of paraplegic rats. Nat Med 4:814-821.
39. Rivlin AS, Tator CH (1977) Objective clinical assessment of motor function after experimental spinal cord injury in the rat. J Neurosurg 47:577-581.
40. Sapolsky RM (1996) Stress, glucocorticoids, and damage to the nervous system: the current state of confusion. Stress 1:1-19.
41. Saville LR, Simedria FC, Weaver LC, Dekaban GA (2002) Treatment of spinal cord injury by using a antibody to the leukocyte integrin alpha D/beta 2 effectively prevents the early infiltration of phagocytes and monocytes/macrophages into the lesion. J Neurotrauma 19:1352.
42. Shanley TP, Warner RL, Crouch LD, Dietsch GN, Clark DL, O'Brien MM, Gallatin WM, Ward PA (1998) Requirements for αd in IgG immune complex-induced rat lung injury. J Immunol 160:1014-1020.
43. Siddall PJ, Taylory D, Cousins MJ (1995) Pain associated with spinal cord injury. Curr Opin Neurol 8:447-450.
44. Snedecor G, Cochran WG (1989) Statistical methods. Iowa: Iowa State UP.
45. Streit WJ, Semple-Rowland SL, Hurley SD, Miller RC, Popovich PG, Stokes BT (1998) Cytokine mRNA profiles in contused spinal cord and axotomized facial nucleus suggest a beneficial role for inflammation and gliosis. Exp Neurol 152:74-87.
46. Taoka Y, Okajima K (1998) Spinal cord injury in the rat. Prog Neurobiol 56:341-358.
47. Taoka Y, Okajima K, Uchiba M, Murakami K, Kushimoto S, Johno M, Naruo M, Okabe H, Takatsuki K (1997) Role of neutrophils in spinal cord injury in the rat. Neuroscience 79:1177-1182.
48. Tator CH, Fehlings MG (1991) Rev of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms. J Neurosurg 75:15-26.
49. Van der Vieren M, Crowe DT, Hoekstra D, Vazeux R, Hoffman PA, Grayson MH, Bochner BS, Gallatin WM, Staunton DE (1999) The leukocyte integrin αDβ2 binds VCAM-1: evidence for a binding interface between 1 domain and VCAM-1. J Immunol 163:1984-1990.
50. Weaver LC, Verghese P, Bruce JC, Fehlings MG, Krenz NR, Marsh DR (2001) Autonomic dysreflexia and primary afferent sprouting after clip-compression injury of the rat spinal cord. J Neurotrauma 18:1107-1119.
51. Wells JE, Hurlbert RJ, Fehlings MG, Yong VW (2003) Neuroprotection by minocycline facilitates significant recovery from spinal cord injury in mice. Brain 126:1628-1637.
52. Woolf CJ, Mannion RJ (1999) Neuropathic pain: aetiology, symptoms, mechanisms, and management. Lancet 353:1959-1964.
53. Xu X-J, Hao JX, Aldskogius H, Seiger Å, Wiesenfeld-Hallin Z (1992) Chronic pain-related syndrome in rats after ischemic spinal cord lesion: a possible animal model for pain in patients with spinal cord injury. Pain 48:279-290.
54. Yezierski RP (1996) Pain following spinal cord injury: the clinical problem and experimental studies. Pain 68:185-194.
55. Young W (1993) Secondary injury mechanisms in acute spinal cord injury. J Emerg Med 11:13-22.