Protein therapy using heme-oxygenase-1 fused to a polyarginine transduction domain attenuates cerebral vasospasm after experimental subarachnoid hemorrhage

Journal of Cerebral Blood Flow and Metabolism

Volumn 31, Issue 11, 2011, Pages 2231-2242

  Ogawa, Tomoyuki ^a,b   Hänggi, Daniel ^a   Wu, Yumei ^b   Michiue, Hiroyuki ^b   Tomizawa, Kazuhito ^c   Ono, Shigeki ^b   Matsui, Hideki ^b   Date, Isao ^b   Steiger, Hans Jakob ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b OKAYAMA UNIVERSITY   (Japan)

^c KUMAMOTO UNIVERSITY   (Japan)

Author keywords

11 consecutive arginines (11R); cerebral vasospasm; heme oxygenase 1 (HO 1); protein transduction domain (PTD); subarachnoid hemorrhage (SAH)

Indexed keywords

CYCLIC GMP; HEME; HEME OXYGENASE 1; HEME OXYGENASE 1 POLYARGININE FUSION PROTEIN; HEMOGLOBIN; MULTIPROTEIN COMPLEX; POLYARGININE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASILAR ARTERY; BRAIN ARTERY; BRAIN VASOSPASM; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; GENE THERAPY; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; RAT; SUBARACHNOID HEMORRHAGE;

ANIMALS; BASILAR ARTERY; BLOTTING, WESTERN; CELL LINE; CELL SURVIVAL; CEREBRAL ARTERIES; DISEASE MODELS, ANIMAL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ESCHERICHIA COLI; HEME OXYGENASE-1; IMMUNOHISTOCHEMISTRY; MALE; PEPTIDES; PLASMIDS; PROTEIN CONFORMATION; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT FUSION PROTEINS; SUBARACHNOID HEMORRHAGE; TRANSDUCTION, GENETIC; VASOSPASM, INTRACRANIAL;

EID: 80455155163     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2011.87     Document Type: Article

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