Spinal microvascular expression of PV-1 is associated with inflammation, perivascular astrocyte loss, and diminished EC glucose transport potential in acute SCI

Current Neurovascular Research

Volumn 7, Issue 3, 2010, Pages 238-250

  Mozer, Anthony B ^a   Whittemore, Scott R ^a   Benton, Richard L ^a,b  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

Caveolae; Inflammation; MECA 32; Microvessels; Neurovascular unit; NVU; PAL E; PLVAP

Indexed keywords

AQUAPORIN 4; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUCOSE TRANSPORTER 1; ISOLECTIN B4; OCCLUDIN; PLASMALEMMAL VESICLE ASSOCIATED PROTEIN 1; PROTEIN; PROTEIN ZO1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BINDING AFFINITY; CELL INFILTRATION; CELL LOSS; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; GLUCOSE TRANSPORT; GRIFFONIA; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INFLAMMATORY CELL; MICROVASCULATURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINAL CORD; SPINAL CORD INJURY; UPREGULATION;

EID: 77956500289     PISSN: 15672026     EISSN: None     Source Type: Journal    
DOI: 10.2174/156720210792231840     Document Type: Article

References (47)

1. Coisne C, Dehouck L, Faveeuw C, et al. Mouse syngenic in vitro blood-brain barrier model: A new tool to examine inflammatory events in cerebral endothelium. Lab Invest 2005; 85(6): 734-46.
2. Stan R, Arden K, Palade G. cDNA and protein sequence, genomic organization, and analysis of cis regulatory elements of mouse and human PLVAP genes. Genomics 2001; 72(3): 304-13.
3. Ciofi P, Garret M, Lapirot O, et al. Brain-endocrine interactions: A microvascular route in the mediobasal hypothalamus. Endocrinology 2009; 150(12): 5509-19.
4. Stan R, Kubitza M, Palade G. PV-1 is a component of the fenestral and stomatal diaphragms in fenestrated endothelia. Proc Natl Acad Sci U S A 1999; 96(23): 13203-7.
5. Stan R, Ghitescu L, Jacobson B, Palade G. Isolation, cloning, and localization of rat PV-1, a novel endothelial caveolar protein. J Cell Biol 1999; 145(6): 189-98.
6. Hnasko R, McFarland M, Ben-Jonathan N. Distribution and characterization of plasmalemma vesicle protein-1 in rat endocrine glands. J Endocrinol 2002; 175(3): 649-61.
7. Yuan J, Pannabecker T. Architecture of inner medullary descending and ascending vasa recta: Pathways for countercurrent exchange. Am J Physiol Renal Physiol 2010; 299(1): F265-72.
8. Yanagawa J, Walser T, Zhu L, et al. Snail promotes CXCR2 ligand-dependent tumor progression in non-small cell lung carcinoma. Clin Cancer Res 2009; 15(22): 6820-9.
9. Hallmann R, Mayer D, Berg E, Broermann R, Butcher E.C. Novel mouse endothelial cell surface marker is suppressed during differentiation of the blood brain barrier. Dev Dyn 1995; 202(4): 325-32.
10. Carson-Walter E, Hampton J, Shue E, et al. Plasmalemmal vesicle associated protein-1 is a novel marker implicated in brain tumor angiogenesis. Clin Cancer Res 2005;11(21): 7643-50.
11. Shue E, Carson-Walter E, Liu Y, et al. Plasmalemmal vesicle associated protein-1 (PV-1) is a marker of blood-brain barrier disruption in rodent models. BMC Neurosci 2008; 9: 29.
12. Klaassen I, Hughes J, Vogels I, et al. Altered expression of genes related to blood-retina barrier disruption in streptozotocin-induced diabetes. Exp Eye Res 2009; 89(1): 4-15.
13. Reiss Y, Hoch G, Deutsch U, Engelhardt B. T cell interaction with ICAM-1-deficient endothelium in vitro: Essential role for ICAM-1 and ICAM-2 in transendothelial migration of T cells. Eur J Immunol 1998; 28(10): 3086-99.
14. del Zoppo G. Inflammation and the neurovascular unit in the setting of focal cerebral ischemia. Neuroscience 2009; 158(3): 972-82.
15. Keuschnigg J, Henttinen T, Auvinen K, Karikoski M, Salmi M, Jalkanen S. The prototype endothelial marker PAL-E is a leukocyte trafficking molecule. Blood 2009;114(2): 478-84.
16. Hawkins B, Davis T. The blood-brain barrier/neurovascular unit in health and disease. Pharmacol Rev 2005; 57(2): 173-85.
17. Whetstone W, Hsu J, Eisenberg M, Werb Z, Noble-Haeusslein, L. Blood-spinal cord barrier after spinal cord injury: Relation to revascularization and wound healing. J Neurosci Res 2003; 74(2): 227-39.
18. Mautes A, Weinzierl M, Donovan F, Noble L. Vascular events after spinal cord injury: Contribution to secondary pathogenesis. Phys Ther 2000; 80(7): 673-87.
19. Casella G, Bunge M, Wood P. Endothelial cell loss is not a major cause of neuronal and glial cell death following contusion injury of the spinal cord. Exp Neurol 2006; 202(1): 8-20.
20. Benton R, Maddie M, Worth C, Mahoney E, Hagg T, Whittemore S. Transcriptomic screening of microvascular endothelial cells implicates novel molecular regulators of vascular dysfunction after spinal cord injury. J Cereb Blood Flow Metab 2008; 28(11): 1771-85.
21. Benton R, Maddie M, Minnillo D, Hagg T, Whittemore S. Griffonia simplicifolia isolectin B4 identifies a specific subpopulation of angiogenic blood vessels following contusive spinal cord injury in the adult mouse. J Comp Neurol 2008;507(1): 1031-52.
22. Loy D, Crawford C, Darnall J, Burke D, Onifer S, Whittemore S. Temporal progression of angiogenesis and basal lamina deposition after contusive spinal cord injury in the adult rat. J Comp Neurol 2002; 445(4): 308-24.
23. Noble L, Mautes A, Hall J. Characterization of the microvascular glycocalyx in normal and injured spinal cord in the rat. J Comp Neurol 1996; 376(4): 542-56.
24. Popovich P, Horner P, Mullin B, Stokes B. A quantitative spatial analysis of the blood-spinal cord barrier. I. Permeability changes after experimental spinal contusion injury. Exp Neurol 1996; 142(2): 258-75.
25. Takigawa T, Yonezawa T, Yoshitaka T, et al. Separation of the perivascular basement membrane provides a conduit for inflammatory cells in a mouse spinal cord injury model. J Neurotrauma 2010; 27(4): 739-51.
26. Noble L, Donovan F, Igarashi T, Goussev S, Werb Z. Matrix metalloproteinases limit functional recovery after spinal cord injury by modulation of early vascular events. J Neurosci 2002; 22(17): 7526-35.
27. Han S, Arnold S, Sithu S, et al. Rescuing vasculature with intravenous angiopoietin-1 and avβ3 integrin peptide is protective after spinal cord injury. Brain 2010; 133(Pt 4): 1026-42.
28. Popovich P, Wei P, Stokes B. Cellular inflammatory response after spinal cord injury in Sprague-Dawley and Lewis rats. J Comp Neurol 1997; 377(3): 443-64.
29. Yamamoto I, Horita S, Takahashi T, et al. Glomerular expression of plasmalemmal vesicle-associated protein-1 in patients with transplant glomerulopathy. Am J Transplant 2007; 7(8): 1954-60.
30. Baba T, Grebe R, Hasegawa T, et al. Maturation of the fetal human choriocapillaris. Invest Ophthalmol Vis Sci 2009; 50(7): 3503-11.
31. Lutty G, Hasegawa T, Baba T, Grebe R, Bhutto I, McLeod D. Development of the human choriocapillaris. Eye (Lond) 2010; 24(3): 408-15.
32. Satchell S, Braet F. Glomerular endothelial cell fenestrations: An integral component of the glomerular filtration barrier. Am J Physiol Renal Physiol 2009; 296(5): F947-56.
33. Noble L, Wrathall J. Distribution and time course of protein extravasation in the rat spinal cord after contusive injury. Brain Res 1989; 482(1): 57-66.
34. Abbott N, Ronnback L, Hansson E. Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci 2006; 7(1): 41-53.
35. Koehler R, Gebremedhin D, Harder D. Role of astrocytes in cerebrovascular regulation. J Appl Physiol 2006; 100(1): 307-17.
36. Iadecola C, Nedergaard M. Glial regulation of the cerebral microvasculature. Nat Neurosci 2007;10(11): 1369-76.
37. Simard M, Arcuino G, Takano T, Liu Q, Nedergaard M. Signaling at the gliovascular interface. J Neurosci 2003; 23(27): 9254-62.
38. Saville L, Pospisil C, Mawhinney L, et al. A monoclonal antibody to CD11d reduces the inflammatory infiltrate into the injured spinal cord: A potential neuroprotective treatment. J Neuroimmunol 2004; 156(1-2): 42-57.
39. Ankeny D , Popovich P. Mechanisms and implications of adaptive immune responses after traumatic spinal cord injury. Neuroscience 2009; 158(3): 1112-21.
40. McTigue D, Tani M, Kravacic K, et al. Selective chemokine mRNA accumulation in the rat spinal cord after contusion injury. J Neurosci Res 1998; 53(3): 368-76.
41. Han H, Suk K. The function and integrity of the neurovascular unit rests upon the integration of the vascular and inflammatory cell systems. Curr Neurovasc Res 2005; 2(5): 409-23.
42. Stirling D,Yong V. Dynamics of the inflammatory response after murine spinal cord injury revealed by flow cytometry. J Neurosci Res 2008; 86(9): 1944-58.
43. Kigerl K, Gensel J, Ankeny D, Alexander J, Donnelly D, Popovich P. Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord. J Neurosci 2009; 29(43): 13435-44.
44. Mosser D, Edwards J. Exploring the full spectrum of macrophage activation. Nat Rev Immunol 2008; 8(12): 958-69.
45. Hamm S, Dehouck B, Kraus J, et al. Astrocyte mediated modulation of blood-brain barrier permeability does not correlate with a loss of tight junction proteins from the cellular contacts. Cell Tissue Res 2004; 315(2): 157-66.
46. Zlokovic B. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 2008; 57(2): 178-201.
47. Stan R. Endothelial stomatal and fenestral diaphragms in normal vessels and angiogenesis. J Cell Mol Med 2007; 11(4): 621-43.