Mild to Moderate Hypothermia Prevents Microvascular Basal Lamina Antigen Loss in Experimental Focal Cerebral Ischemia

Stroke

Volumn 35, Issue 3, 2004, Pages 764-769

  Hamann, Gerhard F ^a,c   Burggraf, Dorothe ^a   Martens, Helge K ^a   Liebetrau, Martin ^a   Jäger, Gabriele ^a   Wunderlich, Nathalie ^a   DeGeorgia, Michael ^b   Krieger, Derk W ^b  

^a UNIVERSITY OF MUNICH   (Germany)

^b LERNER RESEARCH INSTITUTE   (United States)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Basement membrane; Cerebral ischemia; Hypothermia; Metalloproteinases; Microcirculation; Plasminogen activators; Tissue plasminogen activator

Indexed keywords

CASEIN; COLLAGEN TYPE 4; GELATIN; GELATINASE A; GELATINASE B; HEMOGLOBIN; TISSUE PLASMINOGEN ACTIVATOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASEMENT MEMBRANE; BRAIN HEMORRHAGE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN MICROCIRCULATION; BRAIN PERFUSION; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; INDUCED HYPOTHERMIA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; WESTERN BLOTTING; ZYMOGRAPHY;

ANIMALS; ANTIGENS, SURFACE; BASEMENT MEMBRANE; BRAIN; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; COLLAGEN TYPE IV; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; HEMOGLOBINS; HYPOTHERMIA, INDUCED; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICROCIRCULATION; RATS; RATS, WISTAR; REPERFUSION; TISSUE PLASMINOGEN ACTIVATOR; URINARY PLASMINOGEN ACTIVATOR;

EID: 1442299254     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.0000116866.60794.21     Document Type: Article

References (39)

1. del Zoppo GJ, von Kummer R, Hamann GF. Ischaemic damage of brain microvessels: inherent risks for thrombolytic treatment in stroke. J Neurol Neurosurg Psychiatry. 1998;65:1-9.
2. Hamann GF, Okada Y, del Zoppo GJ. Hemorrhagic transformation and microvascular integrity during focal cerebral ischemia/reperfusion. J Cereb Blood Flow Metab. 1996;16:1373-1378.
3. Hamann GF, Okada Y, Fitridge R, del Zoppo GJ. Microvascular basal lamina antigens disappear during cerebral ischemia and reperfusion. Stroke. 1995;26:2120-2126.
4. Yurchenco PD, Schittny JC. Molecular architecture of basement membranes. FASEB J. 1990;4:1577-1590.
5. Hamann GF, del Zoppo GJ, von Kummer R. Hemorrhagic transformation of cerebral infarction: possible mechanisms. Thromb Haemost. 1999;82(suppl):92-94.
6. Petty MA, Wettstein JG. Elements of cerebral microvascular ischemia. Brain Res Rev. 2001;36:23-34.
7. Rosenberg GA, Navratil M, Barone F, Feuerstein G. Proteolytic cascade enzymes increase in focal cerebral ischemia in rat. J Cereb Blood Flow Metab. 1996;16:360-366.
8. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med. 1995;333:1581-1587.
9. Krieger DW, De Georgia MA, Abou-Chebl A. Cooling for acute ischemic brain damage (COOL AID): an open pilot study of induced hypothermia in acute ischemic stroke. Stroke. 2001;32:1847-1854.
10. Correia M, Silva M, Veloso M. Cooling therapy for acute stroke. Cochrane Database Syst Rev. 2000;(2):CD001247.
11. Ishikawa M, Sekizuka E, Sato S. Effects of moderate hypothermia on leukocyte-endothelium interaction in the rat pial microvasculature after transient middle cerebral artery occlusion. Stroke. 1999;30:1679-1686.
12. Globus MY, Alonso O, Dietrich WD, Busto R, Ginsberg MD. Glutamate release and free radical production following brain injury: effects of posttraumatic hypothermia. J Neurochem. 1995;65:1250-1256.
13. Maier CM, Ahern vKB, Cheng ML, Lee JE, Yenari MA, Steinberg GK. Optimal depth and duration of mild hypothermia in a focal model of transient cerebral ischemia. Stroke. 1998;29:2171-2180.
14. Kawai N, Okauchi M, Morisaki K, Nagao S. Effects of delayed intraischemic and postischemic hypothermia on a focal model of transient cerebral ischemia in rats. Stroke. 2000;31:1982-1999.
15. Ginsberg MD, Sternau LL, Globus YT. Therapeutic modulation of brain temperature: relevance to ischemic brain injury. Cereb Brain Metab Rev. 1992;4:189-225.
16. Colbourne F, Corbett D, Zhao Z, Yang J, Buchan AM. Prolonged but delayed postischemic hypothermia: a long-term outcome study in the rat middle cerebral artery occlusion model. J Cereb Blood Flow Metab. 2000;20:1702-1708.
17. Hamann GF, Liebetrau M, Martens HK. Microvascular basal lamina injury following experimental focal cerebral ischemia and reperfusion. J Cereb Blood Flow Metab. 2002;22:526-533.
18. Longa EZ, Weinstein PR, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 1989;20:84-91.
19. Yanamoto H, Nagata I, Nijtsu Y, Zhang Z, Xue JH, Sakai N, Kikuchi H. Prolonged mild hypothermia therapy protects the brain against permanent focal ischemia. Stroke. 2001;32:232-239.
20. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. San Diego, Calif: Academic Press; 1998.
21. Burggraf D, Martens KH, Jäger G, Hamann GF. Recombinant human tissue plasminogen activator protects the basal lamina in experimental focal cerebral ischemia. Thromb Haemost. 2003;89:1072-1080.
22. Heussen C, Dowdle EB. Electrophoretic analysis of plasminogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates. Anal Biochem. 1980;102:196-202.
23. Kloss CU, Thomassen N, Fesl G, Yousri TA, Hamann GF. Tissue-saving infarct volumetry using histochemistry validated by MRI in rat focal ischemia. Neurol Res. 2002;24:713-718.
24. Huber JD, Egleton RD, Davis TP. Molecular physiology and pathophysiology of tight junctions in the blood-brain barrier. Trends Neurosci. 2001;24:719-725.
25. Erickson AC, Couchman JR. Still more complexity in mammalian basement membranes. J Histochem Cytochem. 2000;48:1291-306.
26. Del Zoppo GJ, Hallenbeck JM. Advances in the vascular pathophysiology of ischemic stroke. Thromb Res. 2000;98:73-81.
27. Lijnen HR, Van Hoef B, Lupu F, Moons L, Carmeliet P, Collen D. Function of the plasminogen/plasmin and matrix metalloproteinase systems after vascular injury in mice with targeted inactivation of fibrinolytic system genes. Arterioscler Thromb Vasc Biol. 1998;18:1035-1045.
28. Hosomi N, Lucero J, Heo JH, Koziol JA, Copeland BR, del Zoppo GJ. Rapid differential endogenous plasminogen activator expression after acute middle cerebral artery occlusion. Stroke. 2001;32:1341-1348.
29. Del Zoppo GJ. Microvascular changes during cerebral ischemia and reperfusion. Cerebrovasc Brain Metab Rev. 1994;6:47-96.
30. Nagai N, Vanlinthout I, Collen D. Comparative effects of tissue plasminogen activator, streptokinase, and staphylokinase on cerebral ischemic infarction and pulmonary clot lysis in hamster models. Circulation. 1999; 100:2541-2546.
31. Liotta LA, Goldfarb RH, Terranova VP. Cleavage of laminin by thrombin and plasmin: alpha thrombin selectively cleaves the beta chain of laminin. Thromb Res. 1981;21:663-673.
32. Rosenberg GA, Navratil M. Metalloproteinase inhibition blocks edema in intracerebral hemorrhage in the rat. Neurology. 1997;48:921-926.
33. Lukes A, Mun-Bryce S, Lukes M. Extracellular matrix degradation by metalloproteinases and central nervous system diseases. Mol Neurobiol. 1999;19:267-284.
34. Romanic AM, White RF, Arleth AJ. Matrix metalloproteinase expression increases after cerebral focal ischemia in rats: inhibition of matrix metalloproteinase-9 reduces infarct size. Stroke. 1998;29:1020-1030.
35. Rosenberg GA, Cunningham LA, Wallace J. Immunohistochemistry of matrix metalloproteinases in reperfusion injury to rat brain: activation of MMP-9 linked to stromelysin-1 and microglia in cell cultures. Brain Res. 2001;893:104-112.
36. Rosenberg GA, Estrada EY, Dencoff JE. Matrix metalloproteinases and TIMPs are associated with blood-brain barrier opening after reperfusion in rat brain. Stroke. 1998;29:2189-2195.
37. Menshikov M, Elizarova E, Plakida K. Urokinase upregulates matrix metalloproteinase-9 expression in THP-1 monocytes in gene transcription and protein synthesis. Biochem J. 2002;epub 12 Jul; 10.1042/BJ20020663.
38. Bernard SA, Gray TW, Buist MD. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med. 2002;346:557-563.
39. The Hypothermia After Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med. 2002;346:549-556.