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Volumn 87, Issue 11, 2009, Pages 2571-2577

Neurovascular effects of CD47 signaling: Promotion of cell death, inflammation, and suppression of angiogenesis in brain endothelial cells in vitro

Author keywords

Angiogenesis; CD47; Cell death; Endothelial cell; Inflammation

Indexed keywords

CD47 ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; THROMBOSPONDIN 1; VASCULAR CELL ADHESION MOLECULE 1; 4N1K PEPTIDE; CD47 PROTEIN, HUMAN; CD47 PROTEIN, MOUSE; OLIGOPEPTIDE;

EID: 70349242264     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22076     Document Type: Article
Times cited : (28)

References (56)
  • 1
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions at the blood-brain barrier
    • Abbott NJ, Ronnback L, Hansson E. 2006. Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci 7:41-53.
    • (2006) Nat Rev Neurosci , vol.7 , pp. 41-53
    • Abbott, N.J.1    Ronnback, L.2    Hansson, E.3
  • 3
    • 56549121532 scopus 로고    scopus 로고
    • Thrombospondin-1 binds to ApoER2 and VLDL receptor and functions in postnatal neuronal migration
    • Blake SM, Strasser V, Andrade N, Duit S, Hofbauer R, Schneider WJ, Nimpf J. 2008. Thrombospondin-1 binds to ApoER2 and VLDL receptor and functions in postnatal neuronal migration. EMBO J 27:3069-3080.
    • (2008) EMBO J , vol.27 , pp. 3069-3080
    • Blake, S.M.1    Strasser, V.2    Andrade, N.3    Duit, S.4    Hofbauer, R.5    Schneider, W.J.6    Nimpf, J.7
  • 5
    • 20044373442 scopus 로고    scopus 로고
    • Emerging biological roles for erythropoietin in the nervous system
    • DOI 1038/nrn1687
    • Brines M, Cerami A. 2005. Emerging biological roles for erythropoietin in the nervous system. Nat Rev Neurosci 6:484-494. (Pubitemid 40769173)
    • (2005) Nature Reviews Neuroscience , vol.6 , Issue.6 , pp. 484-494
    • Brines, M.1    Cerami, A.2
  • 6
    • 0035280238 scopus 로고    scopus 로고
    • Integrin-associated protein (CD47) and its ligands
    • Brown EJ, Frazier WA. 2001. Integrin-associated protein (CD47) and its ligands. Trends Cell Biol 11:130-135.
    • (2001) Trends Cell Biol , vol.11 , pp. 130-135
    • Brown, E.J.1    Frazier, W.A.2
  • 7
    • 3242726945 scopus 로고    scopus 로고
    • CXCR3 marks CD4+ memory T lymphocytes that are competent to migrate across a human brain microvascular endothelial cell layer
    • DOI 10.1016/j.jneuroim.2004.05.004, PII S016557280400164X
    • Callahan MK, Williams KA, Kivisakk P, Pearce D, Stins MF, Ransohoff RM. 2004. CXCR3 marks CD4+ memory T lymphocytes that are competent to migrate across a human brain microvascular endothelial cell layer. J Neuroimmunol 153:150-157. (Pubitemid 38950937)
    • (2004) Journal of Neuroimmunology , vol.153 , Issue.1-2 , pp. 150-157
    • Callahan, M.K.1    Williams, K.A.2    Kivisakk, P.3    Pearce, D.4    Stins, M.F.5    Ransohoff, R.M.6
  • 8
    • 0028086009 scopus 로고
    • Correlation between angiogenesis and basic fibroblast growth factor expression in experimental brain infarct
    • Chen HH, Chien CH, Liu HM. 1994. Correlation between angiogenesis and basic fibroblast growth factor expression in experimental brain infarct. Stroke 25:1651-1657. (Pubitemid 24233974)
    • (1994) Stroke , vol.25 , Issue.8 , pp. 1651-1657
    • Chen, H.H.1    Chien, C.-H.2    Liu, H.M.3
  • 11
  • 14
    • 51949084304 scopus 로고    scopus 로고
    • Injuries to the vascular endothelium: Vascular wall and endothelial dysfunction
    • Fisher M. 2008. Injuries to the vascular endothelium: vascular wall and endothelial dysfunction. Rev Neurol Dis 5(Suppl 1):S4-S11.
    • (2008) Rev Neurol Dis , vol.5 , Issue.SUPPL. 1
    • Fisher, M.1
  • 15
    • 33745763116 scopus 로고    scopus 로고
    • Cerebral preconditioning and ischaemic tolerance
    • Gidday JM. 2006. Cerebral preconditioning and ischaemic tolerance. Nat Rev Neurosci 7:437-448.
    • (2006) Nat Rev Neurosci , vol.7 , pp. 437-448
    • Gidday, J.M.1
  • 16
    • 0027935920 scopus 로고
    • Response of cerebral endothelial cells to hypoxia: Modification by fructose-1,6-bisphosphate but not glutamate receptor antagonists
    • Gobbel GT, Chan TY, Gregory GA, Chan PH. 1994. Response of cerebral endothelial cells to hypoxia: modification by fructose-1,6-bisphosphate but not glutamate receptor antagonists. Brain Res 653:23-30.
    • (1994) Brain Res , vol.653 , pp. 23-30
    • Gobbel, G.T.1    Chan, T.Y.2    Gregory, G.A.3    Chan, P.H.4
  • 17
    • 30744477950 scopus 로고    scopus 로고
    • From angiogenesis to neuropathology
    • Greenberg DA, Jin K. 2005. From angiogenesis to neuropathology. Nature 438:954-959.
    • (2005) Nature , vol.438 , pp. 954-959
    • Greenberg, D.A.1    Jin, K.2
  • 18
    • 0035992710 scopus 로고    scopus 로고
    • Activated protein C: Potential therapy for severe sepsis, thrombosis, and stroke
    • DOI 10.1053/shem.2002.34093
    • Griffin JH, Zlokovic B, Fernandez JA. 2002. Activated protein C: potential therapy for severe sepsis, thrombosis, and stroke. Semin Hematol 39:197-205. (Pubitemid 34793041)
    • (2002) Seminars in Hematology , vol.39 , Issue.3 , pp. 197-205
    • Griffin, J.H.1    Zlokovic, B.2    Fernandez, J.A.3
  • 20
    • 33646491871 scopus 로고    scopus 로고
    • Deficit of CD47 results in a defect of marginal zone dendritic cells, blunted immune response to particulate antigen and impairment of skin dendritic cell migration
    • Hagnerud S, Manna PP, Cella M, Stenberg A, Frazier WA, Colonna M, Oldenborg PA. 2006. Deficit of CD47 results in a defect of marginal zone dendritic cells, blunted immune response to particulate antigen and impairment of skin dendritic cell migration. J Immunol 176:5772-5778.
    • (2006) J Immunol , vol.176 , pp. 5772-5778
    • Hagnerud, S.1    Manna, P.P.2    Cella, M.3    Stenberg, A.4    Frazier, W.A.5    Colonna, M.6    Oldenborg, P.A.7
  • 21
    • 2342614850 scopus 로고    scopus 로고
    • Neurovascular regulation in the normal brain and in Alzheimer's disease
    • Iadecola C. 2004. Neurovascular regulation in the normal brain and in Alzheimer's disease. Nat Rev Neurosci 5:347-360. (Pubitemid 38568496)
    • (2004) Nature Reviews Neuroscience , vol.5 , Issue.5 , pp. 347-360
    • Iadecola, C.1
  • 22
    • 33748747969 scopus 로고    scopus 로고
    • CD47 is necessary for inhibition of nitric oxide-stimulated vascular cell responses by thrombospondin-1
    • DOI 10.1074/jbc.M605040200
    • Isenberg JS, Ridnour LA, Dimitry J, Frazier WA, Wink DA, Roberts DD. 2006. CD47 is necessary for inhibition of nitric oxide-stimulated vascular cell responses by thrombospondin-1. J Biol Chem 281:26069-26080. (Pubitemid 44401813)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.36 , pp. 26069-26080
    • Isenberg, J.S.1    Ridnour, L.A.2    Dimitry, J.3    Frazier, W.A.4    Wink, D.A.5    Roberts, D.D.6
  • 23
    • 0342445431 scopus 로고    scopus 로고
    • Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1
    • DOI 10.1038/71517
    • Jimenez B, Volpert OV, Crawford SE, Febbraio M, Silverstein RL, Bouck N. 2000. Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1. Nat Med 6:41-48. (Pubitemid 30048524)
    • (2000) Nature Medicine , vol.6 , Issue.1 , pp. 41-48
    • Jimenez, B.1    Volpert, O.V.2    Crawford, S.E.3    Febbraio, M.4    Silverstein, R.L.5    Bouck, N.6
  • 24
    • 64249144554 scopus 로고    scopus 로고
    • CD47 gene knockout protects against transient focal cerebral ischemia in mice
    • in press
    • Jin G, Tsuji K, Xing C, Yang YG, Wang X, Lo EH. 2009. CD47 gene knockout protects against transient focal cerebral ischemia in mice. Exp Neurol (in press).
    • (2009) Exp Neurol
    • Jin, G.1    Tsuji, K.2    Xing, C.3    Yang, Y.G.4    Wang, X.5    Lo, E.H.6
  • 25
    • 0442291930 scopus 로고    scopus 로고
    • CD47 Ligation Induces a Rapid Caspase-Independent Apoptosis-Like Cell Death in Human Monocytes and Dendritic Cells
    • DOI 10.1111/j.0300-9475.2004.01355.x
    • Johansson U, Higginbottom K, Londei M. 2004. CD47 ligation induces a rapid caspase-independent apoptosis-like cell death in human monocytes and dendritic cells. Scand J Immunol 59:40-49. (Pubitemid 38186838)
    • (2004) Scandinavian Journal of Immunology , vol.59 , Issue.1 , pp. 40-49
    • Johansson, U.1    Higginbottom, K.2    Londei, M.3
  • 27
    • 4444353257 scopus 로고    scopus 로고
    • Tumor progression: The effects of thrombospondin-1 and -2
    • Lawler J, Detmar M. 2004. Tumor progression: the effects of thrombospondin-1 and -2. Int J Biochem Cell Biol 36:1038-1045.
    • (2004) Int J Biochem Cell Biol , vol.36 , pp. 1038-1045
    • Lawler, J.1    Detmar, M.2
  • 28
    • 33745740520 scopus 로고    scopus 로고
    • Cross talk between the cardiovascular and nervous systems: Neurotrophic effects of vascular endothelial growth factor (VEGF) and angiogenic effects of nerve growth factor (NGF)-implications in drug development
    • Lazarovici P, Marcinkiewicz C, Lelkes PI. 2006. Cross talk between the cardiovascular and nervous systems: neurotrophic effects of vascular endothelial growth factor (VEGF) and angiogenic effects of nerve growth factor (NGF)-implications in drug development. Curr Pharm Des 12:2609-2622.
    • (2006) Curr Pharm Des , vol.12 , pp. 2609-2622
    • Lazarovici, P.1    Marcinkiewicz, C.2    Lelkes, P.I.3
  • 29
    • 0242609993 scopus 로고    scopus 로고
    • Interactions between p38 Mitogen-Activated Protein Kinase and Caspase-3 in Cerebral Endothelial Cell Death after Hypoxia-Reoxygenation
    • DOI 10.1161/01.STR.0000096540.40826.BA
    • Lee SR, Lo EH. 2003. Interactions between p38 mitogen-activated protein kinase and caspase-3 in cerebral endothelial cell death after hypoxia-reoxygenation. Stroke 34:2704-2709. (Pubitemid 37392771)
    • (2003) Stroke , vol.34 , Issue.11 , pp. 2704-2709
    • Lee, S.-R.1    Lo, E.H.2
  • 31
    • 84984763363 scopus 로고    scopus 로고
    • Mechanisms, challenges and opportunities in stroke
    • Lo EH, Dalkara T, Moskowitz MA. 2003. Mechanisms, challenges and opportunities in stroke. Nat Rev Neurosci 4:399-415.
    • (2003) Nat Rev Neurosci , vol.4 , pp. 399-415
    • Lo, E.H.1    Dalkara, T.2    Moskowitz, M.A.3
  • 32
    • 43249116466 scopus 로고    scopus 로고
    • A new penumbra: Transitioning from injury into repair after stroke
    • Lo EH. 2008a. A new penumbra: transitioning from injury into repair after stroke. Nat Med 14:497-500.
    • (2008) Nat Med , vol.14 , pp. 497-500
    • Lo, E.H.1
  • 33
    • 40349085617 scopus 로고    scopus 로고
    • Experimental models, neurovascular mechanisms and translational issues in stroke research
    • Lo EH. 2008b. Experimental models, neurovascular mechanisms and translational issues in stroke research. Br J Pharmacol 153(Suppl 1):S396-S405.
    • (2008) Br J Pharmacol , vol.153 , Issue.SUPPL. 1
    • Lo, E.H.1
  • 35
    • 0037378747 scopus 로고    scopus 로고
    • The mechanism of CD47-dependent killing of T cells: Heterotrimeric Gi-dependent inhibition of protein kinase A
    • Manna PP, Frazier WA. 2003. The mechanism of CD47-dependent killing of T cells: heterotrimeric Gi-dependent inhibition of protein kinase A. J Immunol 170:3544-3553.
    • (2003) J Immunol , vol.170 , pp. 3544-3553
    • Manna, P.P.1    Frazier, W.A.2
  • 36
    • 0842325791 scopus 로고    scopus 로고
    • CD47 mediates killing of breast tumor cells via Gi-dependent inhibition of protein kinase A
    • Manna PP, Frazier WA. 2004. CD47 mediates killing of breast tumor cells via Gi-dependent inhibition of protein kinase A. Cancer Res 64:1026-1036.
    • (2004) Cancer Res , vol.64 , pp. 1026-1036
    • Manna, P.P.1    Frazier, W.A.2
  • 37
    • 0032695010 scopus 로고    scopus 로고
    • CD47 ligation induces caspase-independent cell death in chronic lymphocytic leukemia
    • DOI 10.1038/15233
    • Mateo V, Lagneaux L, Bron D, Biron G, Armant M, Delespesse G, Sarfati M. 1999. CD47 ligation induces caspase-independent cell death in chronic lymphocytic leukemia. Nat Med 5:1277-1284. (Pubitemid 29535605)
    • (1999) Nature Medicine , vol.5 , Issue.11 , pp. 1277-1284
    • Mateo, V.1    Lagneaux, L.2    Bron, D.3    Biron, G.4    Armant, M.5    Delespesse, G.6    Sarfati, M.7
  • 38
    • 0037108440 scopus 로고    scopus 로고
    • Mechanisms of CD47-induced caspase-independent cell death in normal and leukemic cells: Link between phosphatidylserine exposure and cytoskeleton organization
    • Mateo V, Brown EJ, Biron G, Rubio M, Fischer A, Deist FL, Sarfati M. 2002. Mechanisms of CD47-induced caspase-independent cell death in normal and leukemic cells: link between phosphatidylserine exposure and cytoskeleton organization. Blood 100:2882-2890.
    • (2002) Blood , vol.100 , pp. 2882-2890
    • Mateo, V.1    Brown, E.J.2    Biron, G.3    Rubio, M.4    Fischer, A.5    Deist, F.L.6    Sarfati, M.7
  • 39
    • 46249126587 scopus 로고    scopus 로고
    • Drug discovery: A lifeline for suffocating tissues
    • DOI 10.1038/4531194a, PII 4531194A
    • Mazzone M, Carmeliet P. 2008. Drug discovery: a lifeline for suffocating tissues. Nature 453:1194-1195. (Pubitemid 351913585)
    • (2008) Nature , vol.453 , Issue.7199 , pp. 1194-1195
    • Mazzone, M.1    Carmeliet, P.2
  • 42
    • 39449127385 scopus 로고    scopus 로고
    • Thrombospondins use the VLDL receptor and a nonapoptotic pathway to inhibit cell division in microvascular endothelial cells
    • DOI 10.1091/mbc.E07-07-0649
    • Oganesian A, Armstrong LC, Migliorini MM, Strickland DK, Bornstein P. 2008. Thrombospondins use the VLDL receptor and a nonapoptotic pathway to inhibit cell division in microvascular endothelial cells. Mol Biol Cell 19:563-571. (Pubitemid 351272145)
    • (2008) Molecular Biology of the Cell , vol.19 , Issue.2 , pp. 563-571
    • Oganesian, A.1    Armstrong, L.C.2    Migliorini, M.M.3    Strickland, D.K.4    Bornstein, P.5
  • 43
    • 33845656103 scopus 로고    scopus 로고
    • A neurovascular niche for neurogenesis after stroke
    • Ohab JJ, Fleming S, Blesch A, Carmichael ST. 2006. A neurovascular niche for neurogenesis after stroke. J Neurosci 26:13007-13016.
    • (2006) J Neurosci , vol.26 , pp. 13007-13016
    • Ohab, J.J.1    Fleming, S.2    Blesch, A.3    Carmichael, S.T.4
  • 44
    • 0041306120 scopus 로고    scopus 로고
    • Injury-induced neurogenesis in the adult mammalian brain
    • DOI 10.1177/1073858403252680
    • Parent JM. 2003. Injury-induced neurogenesis in the adult mammalian brain. Neuroscientist 9:261-272. (Pubitemid 36899114)
    • (2003) Neuroscientist , vol.9 , Issue.4 , pp. 261-272
    • Parent, J.M.1
  • 45
    • 0028822474 scopus 로고
    • Hypoxia increases the susceptibility to oxidant stress and the permeability of the blood-brain barrier endothelial cell monolayer
    • Plateel M, Dehouck MP, Torpier G, Cecchelli R, Teissier E. 1995. Hypoxia increases the susceptibility to oxidant stress and the permeability of the blood-brain barrier endothelial cell monolayer. J Neurochem 65:2138-2145.
    • (1995) J Neurochem , vol.65 , pp. 2138-2145
    • Plateel, M.1    Dehouck, M.P.2    Torpier, G.3    Cecchelli, R.4    Teissier, E.5
  • 46
    • 35548957889 scopus 로고    scopus 로고
    • Astrocyte metabolism and signaling during brain ischemia
    • DOI 10.1038/nn2004, PII NN2004
    • Rossi DJ, Brady JD, Mohr C. 2007. Astrocyte metabolism and signaling during brain ischemia. Nat Neurosci 10:1377-1386. (Pubitemid 350014689)
    • (2007) Nature Neuroscience , vol.10 , Issue.11 , pp. 1377-1386
    • Rossi, D.J.1    Brady, J.D.2    Mohr, C.3
  • 47
    • 22144442812 scopus 로고    scopus 로고
    • Type 3 repeat/C-terminal domain of thrombospondin-1 triggers caspase-independent cell death through CD47/alphavbeta3 in promyelocytic leukemia NB4 cells
    • DOI 10.1182/blood-2004-09-3585
    • Saumet A, Slimane MB, Lanotte M, Lawler J, Dubernard V. 2005. Type 3 repeat/C-terminal domain of thrombospondin-1 triggers caspase-independent cell death through CD47/alphavbeta3 in promyelocytic leukemia NB4 cells. Blood 106:658-667. (Pubitemid 40981264)
    • (2005) Blood , vol.106 , Issue.2 , pp. 658-667
    • Saumet, A.1    Slimane, M.B.2    Lanotte, M.3    Lawler, J.4    Dubernard, V.5
  • 48
    • 33748463817 scopus 로고    scopus 로고
    • Can angiogenesis be exploited to improve stroke outcome? Mechanisms and therapeutic potential
    • DOI 10.1042/CS20060049
    • Slevin M, Kumar P, Gaffney J, Kumar S, Krupinski J. 2006. Can angiogenesis be exploited to improve stroke outcome? Mechanisms and therapeutic potential. Clin Sci (Lond) 111:171-183. (Pubitemid 44352189)
    • (2006) Clinical Science , vol.111 , Issue.3 , pp. 171-183
    • Slevin, M.1    Kumar, P.2    Gaffney, J.3    Kumar, S.4    Krupinski, J.5
  • 49
    • 58149387074 scopus 로고    scopus 로고
    • Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease-activated receptor 1
    • Thiyagarajan M, Fernandez JA, Lane SM, Griffin JH, Zlokovic BV. 2008. Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease-activated receptor 1. J Neurosci 28:12788-12797.
    • (2008) J Neurosci , vol.28 , pp. 12788-12797
    • Thiyagarajan, M.1    Fernandez, J.A.2    Lane, S.M.3    Griffin, J.H.4    Zlokovic, B.V.5
  • 50
    • 35648934511 scopus 로고    scopus 로고
    • Long-term neuroblast migration along blood vessels in an area with transient angiogenesis and increased vascularization after stroke
    • DOI 10.1161/STROKEAHA.107.488445, PII 0000767020071100000026
    • Thored P, Wood J, Arvidsson A, Cammenga J, Kokaia Z, Lindvall O. 2007. Long-term neuroblast migration along blood vessels in an area with transient angiogenesis and increased vascularization after stroke. Stroke 38:3032-3039. (Pubitemid 350035699)
    • (2007) Stroke , vol.38 , Issue.11 , pp. 3032-3039
    • Thored, P.1    Wood, J.2    Arvidsson, A.3    Cammenga, J.4    Kokaia, Z.5    Lindvall, O.6
  • 51
    • 57549099864 scopus 로고    scopus 로고
    • Role of oxidative stress and caspase 3 in CD47-mediated neuronal cell death
    • Xing C, Lee S, Kim WJ, Jin G, Yang YG, Ji X, Wang X, Lo EH. 2009. Role of oxidative stress and caspase 3 in CD47-mediated neuronal cell death. J Neurochem 108:430-436.
    • (2009) J Neurochem , vol.108 , pp. 430-436
    • Xing, C.1    Lee, S.2    Kim, W.J.3    Jin, G.4    Yang, Y.G.5    Ji, X.6    Wang, X.7    Lo, E.H.8
  • 52
    • 54049103618 scopus 로고    scopus 로고
    • Metabolic downregulation: A key to successful neuroprotection?
    • Yenari M, Kitagawa K, Lyden P, Perez-Pinzon M. 2008. Metabolic downregulation: a key to successful neuroprotection? Stroke 39:2910-2917.
    • (2008) Stroke , vol.39 , pp. 2910-2917
    • Yenari, M.1    Kitagawa, K.2    Lyden, P.3    Perez-Pinzon, M.4
  • 54
    • 21344467707 scopus 로고    scopus 로고
    • Cerebral endothelial cell apoptosis after ischemia-reperfusion: Role of PARP activation and AIF translocation
    • DOI 10.1038/sj.jcbfm.9600081
    • Zhang Y, Zhang X, Park TS, Gidday JM. 2005. Cerebral endothelial cell apoptosis after ischemia-reperfusion: role of PARP activation and AIF translocation. J Cereb Blood Flow Metab 25:868-877. (Pubitemid 40905614)
    • (2005) Journal of Cerebral Blood Flow and Metabolism , vol.25 , Issue.7 , pp. 868-877
    • Zhang, Y.1    Zhang, X.2    Park, T.S.3    Gidday, J.M.4
  • 55
    • 13544268809 scopus 로고    scopus 로고
    • Neurovascular mechanisms of Alzheimer's neurodegeneration
    • Zlokovic BV. 2005. Neurovascular mechanisms of Alzheimer's neurodegeneration. Trends Neurosci 28:202-208.
    • (2005) Trends Neurosci , vol.28 , pp. 202-208
    • Zlokovic, B.V.1
  • 56
    • 38149090292 scopus 로고    scopus 로고
    • The blood-brain barrier in health and chronic neurodegenerative disorders
    • Zlokovic BV. 2008. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 57:178-201.
    • (2008) Neuron , vol.57 , pp. 178-201
    • Zlokovic, B.V.1


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