Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality

Journal of Experimental Medicine

Volumn 203, Issue 6, 2006, Pages 1447-1458

  Yano, Kiichiro ^a   Liaw, Patricia C ^c   Mullington, Janet M ^b   Shih, Shu Ching ^a   Okada, Hitomi ^a   Bodyak, Natalya ^a   Kang, Peter M ^a   Toltl, Lisa ^c   Belikoff, Bryan ^a   Buras, Jon ^a   Simms, Benjamin T ^d   Mizgerd, Joseph P ^d   Carmeliet, Peter ^e   Karumanchi, S Ananth ^a   Aird, William C ^a  

^a Center for Vascular Biology Research   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c MCMASTER UNIVERSITY   (Canada)

^d HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^e DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PLACENTAL GROWTH FACTOR; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

ADENOVIRUS; ANIMAL MODEL; ARTICLE; BLOOD VESSEL PERMEABILITY; ENDOTOXEMIA; HEART FUNCTION; MALE; MORBIDITY; MORTALITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEPSIS;

ANIMALS; CECUM; DISEASE MODELS, ANIMAL; ENDOTOXEMIA; HUMANS; INFLAMMATION; LIPOPOLYSACCHARIDES; MICE; PREGNANCY PROTEINS; SEPSIS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 33745021587     PISSN: 00221007     EISSN: 00221007     Source Type: Journal    
DOI: 10.1084/jem.20060375     Document Type: Article

References (30)

1. Aird, W.C. 2003. The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood. 101:3765-3777.
2. Angus, D.C., W.T. Linde-Zwirble, J. Lidicker, G. Clermont, J. Carcillo, and M.R. Pinsky. 2001. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit. Care Med. 29:1303-1310.
3. Panacek, E.A., J.C. Marshall, T.E. Albertson, D.H. Johnson, S. Johnson, R.D. MacArthur, M. Miller, W.T. Barchuk, S. Fischkoff, M. Kaul, et al. 2004. Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab')2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels. Crit. Care Med. 32:2173-2182.
4. Bernard, G.R., J.L. Vincent, P.F. Laterre, S.P. LaRosa, J.F. Dhainaut, A. Lopez-Rodriguez, J.S. Steingrub, G.E. Garber, J.D. Helterbrand, E.W. Ely, and C.J. Fisher Jr. 2001. Efficacy and safety of recombinant human activated protein C for severe sepsis. N. Engl. J. Med. 344:699-709.
5. Senger, D.R., S.J. Galli, A.M. Dvorak, C.A. Perruzzi, V.S. Harvey, and H.F. Dvorak. 1983. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science. 219:983-985.
6. Leung, D.W., G. Cachianes, W.J. Kuang, D.V. Goeddel, and N. Ferrara. 1989. Vascular endothelial growth factor is a secreted angiogenic mitogen. Science. 246:1306-1309.
7. Claesson-Welsh, L. 2003. Signal transduction by vascular endothelial growth factor receptors. Biochem. Soc. Trans. 31:20-24.
8. Kim, I., S.O. Moon, S.H. Kim, H.J. Kim, Y.S. Koh, and G.Y. Koh. 2001. Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-kappa B activation in endothelial cells. J. Biol. Chem. 276:7614-7620.
9. Reinders, M.E., M. Sho, A. Izawa, P. Wang, D. Mukhopadhyay, K.E. Koss, C.S. Geehan, A.D. Luster, M.H. Sayegh, and D.M. Briscoe. 2003. Proinflammatory functions of vascular endothelial growth factor in alloimmunity. J. Clin. Invest. 112:1655-1665.
10. Lucerna, M., D. Mechtcheriakova, A. Kadl, G. Schabbauer, R. Schafer, F. Gruber, Y. Koshelnick, H.D. Muller, K. Issbrucker, M. Clauss, et al. 2003. NAB2, a corepressor of EGR-1, inhibits vascular endothelial growth factor-mediated gene induction and angiogenic responses of endothelial cells. J. Biol. Chem. 278:11433-11440.
11. Kuenen, B.C., M. Levi, J.C. Meijers, A.K. Kakkar, V.W. van Hinsbergh, P.J. Kostense, H.M. Pinedo, and K. Hoekman. 2002. Analysis of coagulation cascade and endothelial cell activation during inhibition of vascular endothelial growth factor/vascular endothelial growth factor receptor pathway in cancer patients. Arterioscler. Thromb. Vasc. Biol. 22:1500-1505.
12. Harada, M., K. Mitsuyama, H. Yoshida, S. Sakisaka, E. Taniguchi, T. Kawaguchi, M. Ariyoshi, T. Saiki, M. Sakamoto, K. Nagata, et al. 1998. Vascular endothelial growth factor in patients with rheumatoid arthritis. Scand. J. Rheumatol. 27:377-380.
13. Taha, Y., Y. Raab, A. Larsson, M. Carlson, L. Loof, B. Gerdin, and M. Thorn. 2004. Vascular endothelial growth factor (VEGF) - a possible mediator of inflammation and mucosal permeability in patients with collagenous colitis. Dig. Dis. Sci. 49:109-115.
14. van der Flier, M., H.J. van Leeuwen, K.P. van Kessel, J.L. Kimpen, A.I. Hoepelman, and S.P. Geelen. 2005. Plasma vascular endothelial growth factor in severe sepsis. Shock. 23:35-38.
15. Pickkers, P., T. Sprong, L. Eijk, H. Hoeven, P. Smits, and M. Deuren. 2005. Vascular endothelial growth factor is increased during the first 48 hours of human septic shock and correlates with vascular permeability. Shock. 24:508-512.
16. Kendall, R.L., G. Wang, and K.A. Thomas. 1996. Identification of a natural soluble form of the vascular endothelial growth factor receptor, FLT-1, and its heterodimerization with KDR. Biochem. Biophys. Res. Commun. 226:324-328.
17. Kuo, C.J., F. Farnebo, E.Y. Yu, R. Christofferson, R.A. Swearingen, R. Carter, H.A. von Recum, J. Yuan, J. Kamihara, E. Flynn, et al. 2001. Comparative evaluation of the antitumor activity of antiangiogenic proteins delivered by gene transfer. Proc. Natl. Acad. Sci. USA. 98:4605-4610.
18. Maynard, S.E., J.Y. Min, J. Merchan, K.H. Lim, J. Li, S. Mondal, T.A. Libermann, J.P. Morgan, F.W. Sellke, I.E. Stillman, et al. 2003. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J. Clin. Invest. 111:649-658.
19. Stocks, J., D. Bradbury, L. Corbett, L. Pang, and A.J. Knox. 2005. Cytokines upregulate vascular endothelial growth factor secretion by human airway smooth muscle cells: role of endogenous prostanoids. FEBS Lett. 579:2551-2556.
20. Jung, Y.D., W. Liu, N. Reinmuth, S.A. Ahmad, F. Fan, G.E. Gallick, and L.M. Ellis. 2001. Vascular endothelial growth factor is upregulated by interleukin-1 beta in human vascular smooth muscle cells via the P38 mitogen-activated protein kinase pathway. Angiogenesis. 4:155-162.
21. Loeffler, S., B. Fayard, J. Weis, and J. Weissenberger. 2005. Interleukin-6 induces transcriptional activation of vascular endothelial growth factor (VEGF) in astrocytes in vivo and regulates VEGF promoter activity in glioblastoma cells via direct interaction between STAT3 and Sp1. Int. J. Cancer. 115:202-213.
22. Zhao, B., J. Cai, and M. Boulton. 2004. Expression of placenta growth factor is regulated by both VEGF and hyperglycaemia via VEGFR-2. Microvasc. Res. 68:239-246.
23. Ahmad, S., and A. Ahmed. 2004. Elevated placental soluble vascular endothelial growth factor receptor-1 inhibits angiogenesis in preeclampsia. Circ. Res. 95:884-891.
24. Mizgerd, J.P., M.M. Lupa, J. Hjoberg, J.C. Vallone, H.B. Warren, J.P. Butler, and E.S. Silverman. 2004. Roles for early response cytokines during Escherichia coli pneumonia revealed by mice with combined deficiencies of all signaling receptors for TNF and IL-1. Am. J. Physiol. Lung Cell. Mol. Physiol. 286:L1302-L1310.
25. Rice, L., D. Orlow, K. Ceonzo, G.L. Stahl, A.O. Tzianabos, H. Wada, W.C. Aird, and J.A. Buras. 2005. CpG oligodeoxynucleotide protection in polymicrobial sepsis is dependent on interleukin-17. J. Infect. Dis. 191:1368-1376.
26. Liaw, P.C., C.T. Esmon, K. Kahnamoui, S. Schmidt, S. Kahnamoui, G. Ferrell, S. Beaudin, J.A. Julian, J.I. Weitz, M. Crowther, et al. 2004. Patients with severe sepsis vary markedly in their ability to generate activated protein C. Blood. 104:3958-3964.
27. Luttun, A., M. Tjwa, L. Moons, Y. Wu, A. Angelillo-Scherrer, F. Liao, J.A. Nagy, A. Hooper, J. Priller, B. De Klerck, et al. 2002. Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat. Med. 8:831-840.
28. McMullen, J.R., T. Shioi, L. Zhang, O. Tarnavski, M.C. Sherwood, P.M. Kang, and S. Izumo. 2003. Phosphoinositide 3-kinase(p110alpha) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy. Proc. Natl. Acad. Sci. USA. 100:12355-12360.
29. Shioi, T., P.M. Kang, P.S. Douglas, J. Hampe, C.M. Yballe, J. Lawitts, L.C. Cantley, and S. Izumo. 2000. The conserved phosphoinositide 3-kinase pathway determines heart size in mice. EMBO J. 19:2537-2548.
30. Shih, S.C., G.S. Robinson, C.A. Perruzzi, A. Calvo, K. Desai, J.E. Green, I.U. Ali, L.E. Smith, and D.R. Senger. 2002. Molecular profiling of angiogenesis markers. Am. J. Pathol. 161:35-41.