메뉴 건너뛰기




Volumn 6, Issue 2, 2009, Pages 124-131

Neutralizing endogenous VEGF following traumatic spinal cord injury modulates microvascular plasticity but not tissue sparing or functional recovery

Author keywords

Aflibercept; Basso Mouse Scale for Locomotion (BMS); Endothelial; Intravital lectin; Neovascularization; VEGF Trap

Indexed keywords

AFLIBERCEPT; ISOLECTIN B4; VASCULOTROPIN;

EID: 65749108276     PISSN: 15672026     EISSN: None     Source Type: Journal    
DOI: 10.2174/156720209788185678     Document Type: Article
Times cited : (21)

References (54)
  • 2
    • 1842830358 scopus 로고    scopus 로고
    • Age-Related Changes in Vascular Endothelial Growth Factor Dependency and Angiopoietin-1-Induced Plasticity of Adult Blood Vessels
    • DOI 10.1161/01.RES.0000125295.43813.1F
    • Baffert, F, Thurston, G, Rochon-Duck, M, Le, T, Brekken, R, McDonald, DM. (2004) Age-related changes in vascular endothelial growth factor dependency and angiopoietin-1-induced plasticity of adult blood vessels. Circ Res 94: 984-992. (Pubitemid 38490077)
    • (2004) Circulation Research , vol.94 , Issue.7 , pp. 984-992
    • Baffert, F.1    Thurston, G.2    Rochon-Duck, M.3    Le, T.4    Brekken, R.5    McDonald, D.M.6
  • 3
    • 0031419189 scopus 로고    scopus 로고
    • VEGF mRNA induction correlates with changes in the vascular architecture upon spinal cord damage in the rat
    • DOI 10.1111/j.1460-9568.1997.tb01684.x
    • Bartholdi, D, Rubin, BP, Schwab, ME. (1997) VEGF mRNA induction correlates with changes in the vascular architecture upon spinal cord damage in the rat. Eur J Neurosci 9: 2549-2560. (Pubitemid 28082944)
    • (1997) European Journal of Neuroscience , vol.9 , Issue.12 , pp. 2549-2560
    • Bartholdi, D.1    Rubin, B.P.2    Schwab, M.E.3
  • 4
    • 33645983692 scopus 로고    scopus 로고
    • Basso mouse scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains
    • Basso, DM, Fisher, LC, Anderson, AJ, Jakeman, LB, McTigue, DM, Popovich, PG. (2006) Basso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains. J Neurotrauma 23: 635-659. (Pubitemid 43728052)
    • (2006) Journal of Neurotrauma , vol.23 , Issue.5 , pp. 635-659
    • Basso, D.M.1    Fisher, L.C.2    Anderson, A.J.3    Jakeman, L.B.4    McTigue, D.M.5    Popovich, P.G.6
  • 5
    • 0018371110 scopus 로고
    • Microvascular regeneration following spinal cord injury: The growth sequence and permeability properties of new vessels
    • Beggs, JL, Waggener, JD. (1979) Microvascular regeneration following spinal cord injury: the growth sequence and permeability properties of new vessels. Adv Neurol 22: 191-206.
    • (1979) Adv Neurol , vol.22 , pp. 191-206
    • Beggs, J.L.1    Waggener, J.D.2
  • 6
    • 38949158421 scopus 로고    scopus 로고
    • Griffonia simplicifolia isolectin B4 identifies a specific subpopulation of angiogenic blood vessels following contusive spinal cord injury in the adult mouse
    • Benton, RL, Maddie, MA, Minnillo, DR, Hagg, T, Whittemore, SR. (2008a) Griffonia simplicifolia isolectin B4 identifies a specific subpopulation of angiogenic blood vessels following contusive spinal cord injury in the adult mouse. J Comp Neurol 507: 1031-1052.
    • (2008) J Comp Neurol , vol.507 , pp. 1031-1052
    • Benton, R.L.1    Maddie, M.A.2    Minnillo, D.R.3    Hagg, T.4    Whittemore, S.R.5
  • 7
    • 54949153088 scopus 로고    scopus 로고
    • Transcriptomic screening of microvascular endothelial cells implicates novel molecular regulators of vascular dysfunction after spinal cord injury
    • Benton, RL, Maddie, MA, Worth, CA, Mahoney, ET, Hagg, T, Whittemore, SR. (2008b) Transcriptomic screening of microvascular endothelial cells implicates novel molecular regulators of vascular dysfunction after spinal cord injury. J Cereb Blood Flow Metab 28: 1771-1785.
    • (2008) J Cereb Blood Flow Metab , vol.28 , pp. 1771-1785
    • Benton, R.L.1    Maddie, M.A.2    Worth, C.A.3    Mahoney, E.T.4    Hagg, T.5    Whittemore, S.R.6
  • 8
    • 0142116387 scopus 로고    scopus 로고
    • 165 therapy exacerbates secondary damage following spinal cord injury
    • 165 therapy exacerbates secondary damage following spinal cord injury. Neurochem Res 28: 1693-1703.
    • (2003) Neurochem Res , vol.28 , pp. 1693-1703
    • Benton, R.L.1    Whittemore, S.R.2
  • 9
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to anti-angiogenic therapy
    • Bergers, G, Hanahan, D. (2008) Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 8: 592-603.
    • (2008) Nat Rev Cancer , vol.8 , pp. 592-603
    • Bergers, G.1    Hanahan, D.2
  • 10
    • 0026635016 scopus 로고
    • The role of glutamate antagonists for the treatment of CNS injury
    • Bullock, R, Fujisawa, H. (1992) The role of glutamate antagonists for the treatment of CNS injury. J Neurotrauma 9 (Suppl 2): S443-S462.
    • (1992) J Neurotrauma , vol.9 , Issue.SUPPL. 2
    • Bullock, R.1    Fujisawa, H.2
  • 11
    • 26644471951 scopus 로고    scopus 로고
    • Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
    • DOI 10.1016/j.ccr.2005.09.005, PII S1535610805002989
    • Casanovas, O, Hicklin, DJ, Bergers, G, Hanahan, D. (2005) Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 8: 299-309. (Pubitemid 41443415)
    • (2005) Cancer Cell , vol.8 , Issue.4 , pp. 299-309
    • Casanovas, O.1    Hicklin, D.J.2    Bergers, G.3    Hanahan, D.4
  • 12
    • 0036144964 scopus 로고    scopus 로고
    • New vascular tissue rapidly replaces neural parenchyma and vessels destroyed by a contusion injury to the rat spinal cord
    • DOI 10.1006/exnr.2001.7827
    • Casella, GT, Marcillo, A, Bunge, MB, Wood, PM. (2002) New vascular tissue rapidly replaces neural parenchyma and vessels destroyed by a contusion injury to the rat spinal cord. Exp Neurol 173: 63-76. (Pubitemid 34081726)
    • (2002) Experimental Neurology , vol.173 , Issue.1 , pp. 63-76
    • Casella, G.T.B.1    Marcillo, A.2    Bunge, M.B.3    Wood, P.M.4
  • 13
    • 33847332493 scopus 로고    scopus 로고
    • Effects of anti-VEGF antibody on blood-brain barrier disruption in focal cerebral ischemia
    • DOI 10.1016/j.expneurol.2006.11.001, PII S0014488606006121
    • Chi, OZ, Hunter, C, Liu, X, Weiss, HR. (2007) Effects of anti-VEGF antibody on blood-brain barrier disruption in focal cerebral ischemia. Exp Neurol 204: 283-287. (Pubitemid 46330278)
    • (2007) Experimental Neurology , vol.204 , Issue.1 , pp. 283-287
    • Chi, O.Z.1    Hunter, C.2    Liu, X.3    Weiss, H.R.4
  • 14
    • 0014652502 scopus 로고
    • Microvascular response to experimental spinal cord trauma
    • Ducker, TB, Assenmacher, DR. (1969) Microvascular response to experimental spinal cord trauma. Surg Forum 20: 428-430.
    • (1969) Surg Forum , vol.20 , pp. 428-430
    • Ducker, T.B.1    Assenmacher, D.R.2
  • 15
    • 40949148520 scopus 로고    scopus 로고
    • Tumor escape from endogenous, extracellular matrix-associated angiogenesis inhibitors by up-regulation of multiple proangiogenic factors
    • Fernando, NT, Koch, M, Rothrock, C, Gollogly, LK, D'Amore, PA, Ryeom, S, Yoon, SS. (2008) Tumor escape from endogenous, extracellular matrix-associated angiogenesis inhibitors by up-regulation of multiple proangiogenic factors. Clin Cancer Res 14: 1529-1539.
    • (2008) Clin Cancer Res , vol.14 , pp. 1529-1539
    • Fernando, N.T.1    Koch, M.2    Rothrock, C.3    Gollogly, L.K.4    D'Amore, P.A.5    Ryeom, S.6    Yoon, S.S.7
  • 17
    • 34447258681 scopus 로고    scopus 로고
    • Tumor microenvironment abnormalities: Causes, consequences, and strategies to normalize
    • DOI 10.1002/jcb.21187
    • Fukumura, D, Jain, RK. (2007) Tumor microenvironment abnormalities: causes, consequences, and strategies to normalize. J Cell Biochem 101: 937-949. (Pubitemid 47040874)
    • (2007) Journal of Cellular Biochemistry , vol.101 , Issue.4 , pp. 937-949
    • Fukumura, D.1    Jain, R.K.2
  • 19
    • 0030875191 scopus 로고    scopus 로고
    • Local changes in vascular architecture following partial spinal cord lesion in the rat
    • DOI 10.1006/exnr.1997.6449
    • Imperato-Kalmar, EL, McKinney, RA, Schnell, L, Rubin, BP, Schwab, ME. (1997) Local changes in vascular architecture following partial spinal cord lesion in the rat. Exp Neurol 145: 322-328. (Pubitemid 27314784)
    • (1997) Experimental Neurology , vol.145 , Issue.2 I , pp. 322-328
    • Imperato-Kalmar, E.L.1    McKinney, R.A.2    Schnell, L.3    Rubin, B.P.4    Schwab, M.E.5
  • 22
    • 30144445614 scopus 로고    scopus 로고
    • Comparative analysis of lesion development and intraspinal inflammation in four strains of mice following spinal contusion injury
    • Kigerl, KA, McGaughy, VM, Popovich, PG. (2006) Comparative analysis of lesion development and intraspinal inflammation in four strains of mice following spinal contusion injury. J Comp Neurol 494: 578-594.
    • (2006) J Comp Neurol , vol.494 , pp. 578-594
    • Kigerl, K.A.1    McGaughy, V.M.2    Popovich, P.G.3
  • 23
    • 44649103824 scopus 로고    scopus 로고
    • Roles of the endogenous VEGF receptors flt-1 and flk-1 in astroglial and vascular remodeling after brain injury
    • Krum, JM, Mani, N, Rosenstein, JM. (2008) Roles of the endogenous VEGF receptors flt-1 and flk-1 in astroglial and vascular remodeling after brain injury. Exp Neurol 212: 108-117.
    • (2008) Exp Neurol , vol.212 , pp. 108-117
    • Krum, J.M.1    Mani, N.2    Rosenstein, J.M.3
  • 25
    • 0037089824 scopus 로고    scopus 로고
    • Temporal progression of angiogenesis and basal lamina deposition after contusive spinal cord injury in the adult rat
    • DOI 10.1002/cne.10168
    • Loy, DN, Crawford, CH, Darnall, JB, Burke, DA, Onifer, SM, Whittemore, SR. (2002) Temporal progression of angiogenesis and basal lamina deposition after contusive spinal cord injury in the adult rat. J Comp Neurol 445: 308-324. (Pubitemid 34252854)
    • (2002) Journal of Comparative Neurology , vol.445 , Issue.4 , pp. 308-324
    • Loy, D.N.1    Crawford, C.H.2    Darnall, J.B.3    Burke, D.A.4    Onifer, S.M.5    Whittemore, S.R.6
  • 26
    • 0029793371 scopus 로고    scopus 로고
    • During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium
    • DOI 10.1038/nm0996-992
    • Melder, RJ, Koenig, GC, Witwer, BP, Safabakhsh, N, Munn, LL, Jain, RK. (1996) During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium. Nat Med 2: 992-997. (Pubitemid 26306837)
    • (1996) Nature Medicine , vol.2 , Issue.9 , pp. 992-997
    • Melder, R.J.1    Koenig, G.C.2    Witwer, B.P.3    Safabakhsh, N.4    Munn, L.L.5    Jain, R.K.6
  • 27
    • 38649096570 scopus 로고    scopus 로고
    • Modulating Sema3A signal with a L1 mimetic peptide is not sufficient to promote motor recovery and axon regeneration after spinal cord injury
    • Mire, E, Thomasset, N, Jakeman, LB, Rougon, G. (2008) Modulating Sema3A signal with a L1 mimetic peptide is not sufficient to promote motor recovery and axon regeneration after spinal cord injury. Mol Cell Neurosci 37: 222-235.
    • (2008) Mol Cell Neurosci , vol.37 , pp. 222-235
    • Mire, E.1    Thomasset, N.2    Jakeman, L.B.3    Rougon, G.4
  • 29
    • 0030479488 scopus 로고    scopus 로고
    • Characterization of the microvascular glycocalyx in normal and injured spinal cord in the rat
    • DOI 10.1002/(SICI)1096-9861(19961223)376:4<542::AID-CNE4>3.0.CO;2-1
    • Noble, LJ, Mautes, AE, Hall, JJ. (1996) Characterization of the microvascular glycocalyx in normal and injured spinal cord in the rat. J Comp Neurol 376: 542-556. (Pubitemid 27009839)
    • (1996) Journal of Comparative Neurology , vol.376 , Issue.4 , pp. 542-556
    • Noble, L.J.1    Mautes, A.E.M.2    Hall, J.J.3
  • 30
    • 0024515595 scopus 로고
    • Distribution and time course of protein extravasation in the rat spinal cord after contusive injury
    • DOI 10.1016/0006-8993(89)90542-8
    • Noble, LJ, Wrathall, JR. (1989) Distribution and time course of protein extravasation in the rat spinal cord after contusive injury. Brain Res 482: 57-66. (Pubitemid 19063150)
    • (1989) Brain Research , vol.482 , Issue.1 , pp. 57-66
    • Noble, L.J.1    Wrathall, J.R.2
  • 34
    • 0030560684 scopus 로고    scopus 로고
    • A quantitative spatial analysis of the blood-spinal cord barrier I. Permeability changes after experimental spinal contusion injury
    • DOI 10.1006/exnr.1996.0196
    • Popovich, PG, Horner, PJ, Mullin, BB, Stokes, BT. (1996) A quantitative spatial analysis of the blood-spinal cord barrier. I. Permeability changes after experimental spinal contusion injury. Exp Neurol 142: 258-275. (Pubitemid 26414059)
    • (1996) Experimental Neurology , vol.142 , Issue.2 , pp. 258-275
    • Popovich, P.G.1    Horner, P.J.2    Mullin, B.B.3    Stokes, B.T.4
  • 35
    • 0035008642 scopus 로고    scopus 로고
    • Cyclosporin a treatment following spinal cord injury to the rat: Behavioral effects and stereological assessment of tissue sparing
    • Rabchevsky, AG, Fugaccia, I, Sullivan, PG, Scheff, SW. (2001) Cyclosporin. A treatment following spinal cord injury to the rat: behavioral effects and stereological assessment of tissue sparing. J Neurotrauma 18: 513-522. (Pubitemid 32472841)
    • (2001) Journal of Neurotrauma , vol.18 , Issue.5 , pp. 513-522
    • Rabchevsky, A.G.1    Fugaccia, I.2    Sullivan, P.G.3    Scheff, S.W.4
  • 37
    • 33746442378 scopus 로고    scopus 로고
    • VEGF trap as a novel antiangiogenic treatment currently in clinical trials for cancer and eye diseases, and VelociGene-based discovery of the next generation of angiogenesis targets
    • DOI 10.1101/sqb.2005.70.052
    • Rudge, JS, Thurston, G, Davis, S, Papadopoulos, N, Gale, N, Wiegand, SJ, Yancopoulos, GD. (2005) VEGF trap as a novel antiangiogenic treatment currently in clinical trials for cancer and eye diseases, and VelociGene- based discovery of the next generation of angiogenesis targets. Cold Spring Harb Symp Quant Biol 70: 411-418. (Pubitemid 44124896)
    • (2005) Cold Spring Harbor Symposia on Quantitative Biology , vol.70 , pp. 411-418
    • Rudge, J.S.1    Thurston, G.2    Davis, S.3    Papadopoulos, N.4    Gale, N.5    Wiegand, S.J.6    Yancopoulos, G.D.7
  • 40
    • 17844378527 scopus 로고    scopus 로고
    • Pathophysiology of blood-spinal cord barrier in traumatic injury and repair
    • DOI 10.2174/1381612053507837
    • Sharma, HS. (2005) Pathophysiology of blood-spinal cord barrier in traumatic injury and repair. Curr Pharm Des 11: 1353-1389. (Pubitemid 40598002)
    • (2005) Current Pharmaceutical Design , vol.11 , Issue.11 , pp. 1353-1389
    • Sharma, H.S.1
  • 41
    • 55949096784 scopus 로고    scopus 로고
    • Role of the microenvironment in tumor growth and in refractoriness/ resistance to anti-angiogenic therapies
    • Shojaei, F, Ferrara, N. (2008) Role of the microenvironment in tumor growth and in refractoriness/resistance to anti-angiogenic therapies. Drug Resist Updat 11: 219-230.
    • (2008) Drug Resist Updat , vol.11 , pp. 219-230
    • Shojaei, F.1    Ferrara, N.2
  • 42
    • 0033788609 scopus 로고    scopus 로고
    • Induction of VEGF and VEGF receptors in the spinal cord after mechanical spinal injury and prostaglandin administration
    • Skold, M, Cullheim, S, Hammarberg, H, Piehl, F, Suneson, A, Lake, S, Sjogren, A, Walum, E, Risling, M. (2000) Induction of VEGF and VEGF receptors in the spinal cord after mechanical spinal injury and prostaglandin administration. Eur J Neurosci 12: 3675-3686.
    • (2000) Eur J Neurosci , vol.12 , pp. 3675-3686
    • Skold, M.1    Cullheim, S.2    Hammarberg, H.3    Piehl, F.4    Suneson, A.5    Lake, S.6    Sjogren, A.7    Walum, E.8    Risling, M.9
  • 45
    • 38349026285 scopus 로고    scopus 로고
    • Changes in PDGF expression in spared dorsal root ganglia and associated spinal dorsal horns in cats subjected to partial dorsal root ganglionectomy
    • Sun, WW, Liu, J, Wang, XY, Zhang, LS, Zhang, W, Li, LY, Li, H, Wang, TH. (2008) Changes in PDGF expression in spared dorsal root ganglia and associated spinal dorsal horns in cats subjected to partial dorsal root ganglionectomy. Neurosci Lett 431: 112-117.
    • (2008) Neurosci Lett , vol.431 , pp. 112-117
    • Sun, W.W.1    Liu, J.2    Wang, X.Y.3    Zhang, L.S.4    Zhang, W.5    Li, L.Y.6    Li, H.7    Wang, T.H.8
  • 47
    • 53849106782 scopus 로고    scopus 로고
    • VEGF and Delta-Notch: Interacting signalling pathways in tumour angiogenesis
    • Thurston, G, Kitajewski, J. (2008) VEGF and Delta-Notch: interacting signalling pathways in tumour angiogenesis. Br J Cancer 99: 1204-1209.
    • (2008) Br J Cancer , vol.99 , pp. 1204-1209
    • Thurston, G.1    Kitajewski, J.2
  • 48
    • 2542628099 scopus 로고    scopus 로고
    • Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors
    • DOI 10.1158/0008-5472.CAN-04-0074
    • Tong, RT, Boucher, Y, Kozin, SV, Winkler, F, Hicklin, DJ, Jain, RK. (2004) Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Res 64: 3731-3736. (Pubitemid 38697278)
    • (2004) Cancer Research , vol.64 , Issue.11 , pp. 3731-3736
    • Tong, R.T.1    Boucher, Y.2    Kozin, S.V.3    Winkler, F.4    Hicklin, D.J.5    Jain, R.K.6
  • 49
    • 50249150269 scopus 로고    scopus 로고
    • Chronically increased ciliary neurotrophic factor and fibroblast growth factor-2 expression after spinal contusion in rats
    • Tripathi, RB, McTigue, DM. (2008) Chronically increased ciliary neurotrophic factor and fibroblast growth factor-2 expression after spinal contusion in rats. J Comp Neurol 510: 129-144.
    • (2008) J Comp Neurol , vol.510 , pp. 129-144
    • Tripathi, R.B.1    McTigue, D.M.2
  • 50
    • 0032921140 scopus 로고    scopus 로고
    • Vascular endothelial growth/permeability factor in spinal cord injury
    • Vaquero, J, Zurita, M, de Oya, S, Coca, S. (1999) Vascular endothelial growth/permeability factor in spinal cord injury. J Neurosurg 90: 220-223. (Pubitemid 29155903)
    • (1999) Journal of Neurosurgery , vol.90 , Issue.4 SUPPL. , pp. 220-223
    • Vaquero, J.1    Zurita, M.2    De Oya, S.3    Coca, S.4
  • 52
    • 0042133340 scopus 로고    scopus 로고
    • Vascular endothelial growth factor improves functional outcome and decreases secondary degeneration in experimental spinal cord contusion injury
    • DOI 10.1016/S0306-4522(03)00399-3
    • Widenfalk, J, Lipson, A, Jubran, M, Hofstetter, C, Ebendal, T, Cao, Y, Olson, L. (2003) Vascular endothelial growth factor improves functional outcome and decreases secondary degeneration in experimental spinal cord contusion injury. Neuroscience 120: 951-960. (Pubitemid 36966647)
    • (2003) Neuroscience , vol.120 , Issue.4 , pp. 951-960
    • Widenfalk, J.1    Lipson, A.2    Jubran, M.3    Hofstetter, C.4    Ebendal, T.5    Cao, Y.6    Olson, L.7
  • 53
    • 0028234273 scopus 로고
    • Experimental intracerebral hemorrhage: Relationship between brain edema, blood flow, and blood-brain barrier permeability in rats
    • Yang, GY, Betz, AL, Chenevert, TL, Brunberg, JA, Hoff, JT. (1994) Experimental intracerebral hemorrhage: relationship between brain edema, blood flow, and blood-brain barrier permeability in rats. J Neurosurg 81: 93-102. (Pubitemid 24195513)
    • (1994) Journal of Neurosurgery , vol.81 , Issue.1 , pp. 93-102
    • Yang, G.-Y.1    Betz, A.L.2    Chenevert, T.L.3    Brunberg, J.A.4    Hoff, J.T.5
  • 54
    • 0031239077 scopus 로고    scopus 로고
    • Experimental spinal cord injury: Wallerian degeneration in the dorsal column is followed by revascularization, glial proliferation, and nerve regeneration
    • DOI 10.1006/exnr.1997.6590
    • Zhang, Z, Guth, L. (1997) Experimental spinal cord injury: Wallerian degeneration in the dorsal column is followed by revascularization, glial proliferation, and nerve regeneration. Exp Neurol 147: 159-171. (Pubitemid 27402453)
    • (1997) Experimental Neurology , vol.147 , Issue.1 , pp. 159-171
    • Zhang, Z.1    Guth, L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.