메뉴 건너뛰기




Volumn 12, Issue 1, 2012, Pages 93-106

Molecular changes in smoking-related lung cancer

Author keywords

DNA methylation; epigenetic alterations; epigenetics; genetic alterations; key pathways; lung cancer; miRNA; mutation; non small cell lung cancer; smoking

Indexed keywords

ACROLEIN; ANTIOXIDANT; APC PROTEIN; B RAF KINASE; CARBON MONOXIDE; CIGARETTE SMOKE; CYCLIN DEPENDENT KINASE INHIBITOR 2A; FRAGILE HISTIDINE TRIAD PROTEIN; HYDROCARBON; K RAS PROTEIN; MALOTILATE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; MICRORNA; NICOTINE; OXIDIZING AGENT; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE LKB1; PROTEIN P16; PROTEIN P53; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; SCATTER FACTOR RECEPTOR; TRANSCRIPTION FACTOR FKHRL1; TRANSCRIPTION FACTOR RUNX3;

EID: 82955217696     PISSN: 14737159     EISSN: 17448352     Source Type: Journal    
DOI: 10.1586/erm.11.84     Document Type: Review
Times cited : (16)

References (130)
  • 1
    • 79960311742 scopus 로고    scopus 로고
    • An epigenetic marker panel for detection of lung cancer using cell-free serum DNA
    • Begum S, Brait M, Dasgupta S et al. An epigenetic marker panel for detection of lung cancer using cell-free serum DNA. Clin. Cancer Res. 17(13), 4494-4503 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , Issue.13 , pp. 4494-4503
    • Begum, S.1    Brait, M.2    Dasgupta, S.3
  • 2
    • 78650425377 scopus 로고    scopus 로고
    • Genetic and epigenetic analysis of erbB signaling pathway genes in lung cancer
    • Hoque MO, Brait M, Rosenbaum E et al. Genetic and epigenetic analysis of erbB signaling pathway genes in lung cancer. J. Thorac. Oncol. 5(12), 1887-1893 (2010).
    • (2010) J. Thorac. Oncol. , vol.5 , Issue.12 , pp. 1887-1893
    • Hoque, M.O.1    Brait, M.2    Rosenbaum, E.3
  • 3
    • 77954222909 scopus 로고    scopus 로고
    • Molecular analysis of plasma DNA for the early detection of lung cancer by quantitative methylation-specific PCR
    • Demonstrates that methylation frequencies of a panel of genes progressively increase with pack-per-year smoking
    • Ostrow KL, Hoque MO, Loyo M et al. Molecular analysis of plasma DNA for the early detection of lung cancer by quantitative methylation-specific PCR. Clin. Cancer Res. 16(13), 3463-3472 (2010). Demonstrates that methylation frequencies of a panel of genes progressively increase with pack-per-year smoking.
    • (2010) Clin. Cancer Res. , vol.16 , Issue.13 , pp. 3463-3472
    • Ostrow, K.L.1    Hoque, M.O.2    Loyo, M.3
  • 4
    • 72749090135 scopus 로고    scopus 로고
    • Association between lifestyle factors and CpG island methylation in a cancer-free population
    • Demonstrates methylation of some key genes in plasma of a high-risk cancer-free population
    • Brait M, Ford JG, Papaiahgari S et al. Association between lifestyle factors and CpG island methylation in a cancer-free population. Cancer Epidemiol. Biomarkers Prev. 18(11), 2984-2991 (2009). Demonstrates methylation of some key genes in plasma of a high-risk cancer-free population.
    • (2009) Cancer Epidemiol. Biomarkers Prev. , vol.18 , Issue.11 , pp. 2984-2991
    • Brait, M.1    Ford, J.G.2    Papaiahgari, S.3
  • 5
    • 18544365698 scopus 로고    scopus 로고
    • Gene-expression profiles predict survival of patients with lung adenocarcinoma
    • Beer DG, Kardia SL, Huang CC et al. Gene-expression profiles predict survival of patients with lung adenocarcinoma. Nat. Med. 8(8), 816-824 (2002).
    • (2002) Nat. Med. , vol.8 , Issue.8 , pp. 816-824
    • Beer, D.G.1    Kardia, S.L.2    Huang, C.C.3
  • 6
    • 33845877973 scopus 로고    scopus 로고
    • A gene expression signature predicts survival of patients with Stage 1 non-small cell lung cancer
    • Lu Y, Lemon W, Liu PY et al. A gene expression signature predicts survival of patients with Stage 1 non-small cell lung cancer. PLoS Med. 3(12), e467 (2006).
    • (2006) PLoS Med. , vol.3 , Issue.12
    • Lu, Y.1    Lemon, W.2    Liu, P.Y.3
  • 7
    • 20344407567 scopus 로고    scopus 로고
    • Prediction of lymph node metastasis by analysis of gene expression profiles in primary lung adenocarcinomas
    • Xi L, Lyons-Weiler J, Coello MC et al. Prediction of lymph node metastasis by analysis of gene expression profiles in primary lung adenocarcinomas. Clin. Cancer Res. 11(11), 4128-4135 (2005).
    • (2005) Clin. Cancer Res. , vol.11 , Issue.11 , pp. 4128-4135
    • Xi, L.1    Lyons-Weiler, J.2    Coello, M.C.3
  • 8
    • 79955983366 scopus 로고    scopus 로고
    • Molecular characteristics predict clinical outcomes: Prospective trial correlating response to the EGFR tyrosine kinase inhibitor gefitinib with the presence of sensitizing mutations in the tyrosine binding domain of the EGFR gene
    • Rizvi NA, Rusch V, Pao W et al. Molecular characteristics predict clinical outcomes: Prospective trial correlating response to the EGFR tyrosine kinase inhibitor gefitinib with the presence of sensitizing mutations in the tyrosine binding domain of the EGFR gene. Clin. Cancer Res. 17 (10), 3500-3506 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , Issue.10 , pp. 3500-3506
    • Rizvi, N.A.1    Rusch, V.2    Pao, W.3
  • 9
    • 33646108136 scopus 로고    scopus 로고
    • Quantitative puff-by-puff-resolved characterization of selected toxic compounds in cigarette mainstream smoke
    • Adam T, Mitschke S, Streibel T, Baker RR, Zimmermann R. Quantitative puff-by-puff-resolved characterization of selected toxic compounds in cigarette mainstream smoke. Chem. Res. Toxicol. 19(4), 511-520 (2006).
    • (2006) Chem. Res. Toxicol. , vol.19 , Issue.4 , pp. 511-520
    • Adam, T.1    Mitschke, S.2    Streibel, T.3    Baker, R.R.4    Zimmermann, R.5
  • 10
    • 4344594118 scopus 로고    scopus 로고
    • A review of the influence of particle size, puff volume, and inhalation pattern on the deposition of cigarette smoke particles in the respiratory tract
    • Bernstein D. A review of the influence of particle size, puff volume, and inhalation pattern on the deposition of cigarette smoke particles in the respiratory tract. Inhal. Toxicol. 16(10), 675-689 (2004).
    • (2004) Inhal. Toxicol. , vol.16 , Issue.10 , pp. 675-689
    • Bernstein, D.1
  • 11
    • 61449083796 scopus 로고    scopus 로고
    • Tobacco smoke: Involvement of reactive oxygen species and stable free radicals in mechanisms of oxidative damage, carcinogenesis and synergistic effects with other respirable particles
    • Valavanidis A, Vlachogianni T, Fiotakis K. Tobacco smoke: Involvement of reactive oxygen species and stable free radicals in mechanisms of oxidative damage, carcinogenesis and synergistic effects with other respirable particles. Int. J. Environ. Res. Public Health 6(2), 445-462 (2009).
    • (2009) Int. J. Environ. Res. Public Health , vol.6 , Issue.2 , pp. 445-462
    • Valavanidis, A.1    Vlachogianni, T.2    Fiotakis, K.3
  • 12
    • 51449086178 scopus 로고    scopus 로고
    • Surveillance for cancers associated with tobacco use-United States, 1999-2004
    • Stewart SL, Cardinez CJ, Richardson LC et al. Surveillance for cancers associated with tobacco use-United States, 1999-2004. MMWR Surveill. Summ. 57(8), 1-33 (2008).
    • (2008) MMWR Surveill. Summ. , vol.57 , Issue.8 , pp. 1-33
    • Stewart, S.L.1    Cardinez, C.J.2    Richardson, L.C.3
  • 13
    • 79952213804 scopus 로고    scopus 로고
    • A Report of the Surgeon GeneralPublic Health Service Office of the Surgeon General, US Department of Health and Human Services, Rockville MD, USA
    • A Report of the Surgeon General. How Tobacco Smoke Causes Disease: The Biology and Behavioral Basis for Smoking-Attributable Disease. Public Health Service Office of the Surgeon General, US Department of Health and Human Services, Rockville, MD, USA (2010).
    • (2010) How Tobacco Smoke Causes Disease: The Biology and Behavioral Basis for Smoking-Attributable Disease
  • 14
    • 29544445384 scopus 로고    scopus 로고
    • Effects of prenatal exposure to cigarette smoke on offspring tumor susceptibility and associated immune mechanisms
    • Ng SP, Silverstone AE, Lai ZW, Zelikoff JT. Effects of prenatal exposure to cigarette smoke on offspring tumor susceptibility and associated immune mechanisms. Toxicol. Sci. 89(1), 135-144 (2006).
    • (2006) Toxicol. Sci. , vol.89 , Issue.1 , pp. 135-144
    • Ng, S.P.1    Silverstone, A.E.2    Lai, Z.W.3    Zelikoff, J.T.4
  • 15
    • 34548142651 scopus 로고    scopus 로고
    • Chromosomal aberrations of malignant pleural effusions of lung adenocarcinoma: Different cytogenetic changes are correlated with genders and smoking habits
    • Yen CC, Liang SC, Jong YJ et al. Chromosomal aberrations of malignant pleural effusions of lung adenocarcinoma: Different cytogenetic changes are correlated with genders and smoking habits. Lung Cancer 57(3), 292-301 (2007).
    • (2007) Lung Cancer , vol.57 , Issue.3 , pp. 292-301
    • Yen, C.C.1    Liang, S.C.2    Jong, Y.J.3
  • 16
    • 33644697320 scopus 로고    scopus 로고
    • Deletions at chromosome 2q and 12p are early and frequent molecular alterations in bronchial epithelium and NSCLC of long-term smokers
    • Grepmeier U, Dietmaier W, Merk J et al. Deletions at chromosome 2q and 12p are early and frequent molecular alterations in bronchial epithelium and NSCLC of long-term smokers. Int. J. Oncol. 27(2), 481-488 (2005).
    • (2005) Int. J. Oncol. , vol.27 , Issue.2 , pp. 481-488
    • Grepmeier, U.1    Dietmaier, W.2    Merk, J.3
  • 17
    • 17444402800 scopus 로고    scopus 로고
    • Frequency of loss of heterozygosity at 3 p, 9 p, 13 q, and 17 p is related to proliferative activity in smokers with stage I non-small cell lung cancer
    • Haga Y, Hiroshima K, Iyoda A et al. Frequency of loss of heterozygosity at 3 p, 9 p, 13 q, and 17 p is related to proliferative activity in smokers with stage I non-small cell lung cancer. Thorac. Cardiovasc. Surg. 53(2), 114-117 (2005).
    • (2005) Thorac. Cardiovasc. Surg. , vol.53 , Issue.2 , pp. 114-117
    • Haga, Y.1    Hiroshima, K.2    Iyoda, A.3
  • 18
    • 26444596500 scopus 로고    scopus 로고
    • Alterations of 9p in squamous cell carcinoma and adenocarcinoma of the lung: Association with smoking, TP53, and survival
    • Marsit CJ, Wiencke JK, Nelson HH et al. Alterations of 9p in squamous cell carcinoma and adenocarcinoma of the lung: Association with smoking, TP53, and survival. Cancer Genet. Cytogenet. 162(2), 115-121 (2005).
    • (2005) Cancer Genet. Cytogenet. , vol.162 , Issue.2 , pp. 115-121
    • Marsit, C.J.1    Wiencke, J.K.2    Nelson, H.H.3
  • 19
    • 16444374716 scopus 로고    scopus 로고
    • Loss of heterozygosity patterns provide fingerprints for genetic heterogeneity in multistep cancer progression of tobacco smoke-induced non-small cell lung cancer
    • Pan H, Califano J, Ponte JF et al. Loss of heterozygosity patterns provide fingerprints for genetic heterogeneity in multistep cancer progression of tobacco smoke-induced non-small cell lung cancer. Cancer Res. 65(5), 1664-1669 (2005).
    • (2005) Cancer Res. , vol.65 , Issue.5 , pp. 1664-1669
    • Pan, H.1    Califano, J.2    Ponte, J.F.3
  • 20
    • 27144529512 scopus 로고    scopus 로고
    • Identification of tumor suppressor loci on the long arm of chromosome 5 in pulmonary large cell neuroendocrine carcinoma
    • Shin JH, Kang SM, Kim YS et al. Identification of tumor suppressor loci on the long arm of chromosome 5 in pulmonary large cell neuroendocrine carcinoma. Chest 128(4), 2999-3003 (2005).
    • (2005) Chest , vol.128 , Issue.4 , pp. 2999-3003
    • Shin, J.H.1    Kang, S.M.2    Kim, Y.S.3
  • 21
    • 34250346443 scopus 로고    scopus 로고
    • Relationship between the loss of heterozygosity and tobacco smoking in pulmonary adenocarcinoma
    • Yohena T, Yoshino I, Takenaka T et al. Relationship between the loss of heterozygosity and tobacco smoking in pulmonary adenocarcinoma. Oncol. Res. 16(7), 333-339 (2007).
    • (2007) Oncol. Res. , vol.16 , Issue.7 , pp. 333-339
    • Yohena, T.1    Yoshino, I.2    Takenaka, T.3
  • 22
    • 0036481752 scopus 로고    scopus 로고
    • Reduced Fhit protein expression and loss of heterozygosity at FHIT gene in tumours from smoking and asbestos-exposed lung cancer patients
    • Pylkkanen L, Wolff H, Stjernvall T et al. Reduced Fhit protein expression and loss of heterozygosity at FHIT gene in tumours from smoking and asbestos-exposed lung cancer patients. Int. J. Oncol. 20(2), 285-290 (2002).
    • (2002) Int. J. Oncol. , vol.20 , Issue.2 , pp. 285-290
    • Pylkkanen, L.1    Wolff, H.2    Stjernvall, T.3
  • 23
    • 13944258204 scopus 로고    scopus 로고
    • Loss of heterozygosity (LOH) in non-small cell lung cancer: Difference between adenocarcinoma and squamous cell carcinoma
    • Yoshino I, Osoegawa A, Yohena T et al. Loss of heterozygosity (LOH) in non-small cell lung cancer: Difference between adenocarcinoma and squamous cell carcinoma. Respir. Med. 99(3), 308-312 (2005).
    • (2005) Respir. Med. , vol.99 , Issue.3 , pp. 308-312
    • Yoshino, I.1    Osoegawa, A.2    Yohena, T.3
  • 24
    • 1842298166 scopus 로고    scopus 로고
    • Clonal genetic alterations in the lungs of current and former smokers
    • Mao L, Lee JS, Kurie JM et al. Clonal genetic alterations in the lungs of current and former smokers. J. Natl Cancer Inst. 857-862 (1997).
    • (1997) J. Natl Cancer Inst. , pp. 857-862
    • Mao, L.1    Lee, J.S.2    Kurie, J.M.3
  • 25
    • 70449659333 scopus 로고    scopus 로고
    • Relationship between TP53 tumour suppressor gene mutations and smoking-related bulky DNA adducts in a lung cancer study population from Hungary
    • Anna L, Holmila R, Kovacs K et al. Relationship between TP53 tumour suppressor gene mutations and smoking-related bulky DNA adducts in a lung cancer study population from Hungary. Mutagenesis 24(6), 475-480 (2009).
    • (2009) Mutagenesis , vol.24 , Issue.6 , pp. 475-480
    • Anna, L.1    Holmila, R.2    Kovacs, K.3
  • 26
    • 33748046788 scopus 로고    scopus 로고
    • Quantitative detection of p53 mutations in plasma DNA from tobacco smokers
    • Hagiwara N, Mechanic LE, Trivers GE et al. Quantitative detection of p53 mutations in plasma DNA from tobacco smokers. Cancer Res. 66(16), 8309-8317 (2006).
    • (2006) Cancer Res. , vol.66 , Issue.16 , pp. 8309-8317
    • Hagiwara, N.1    Mechanic, L.E.2    Trivers, G.E.3
  • 27
    • 1842856019 scopus 로고    scopus 로고
    • Molecular footprints of human lung cancer progression
    • Yokota J, Kohno T. Molecular footprints of human lung cancer progression. Cancer Sci. 95(3), 197-204 (2004).
    • (2004) Cancer Sci. , vol.95 , Issue.3 , pp. 197-204
    • Yokota, J.1    Kohno, T.2
  • 28
    • 0037448026 scopus 로고    scopus 로고
    • On the origin of G → T transversions in lung cancer
    • Pfeifer GP, Hainaut P. On the origin of G → T transversions in lung cancer. Mutat. Res. 526 (1-2), 39-43 (2003).
    • (2003) Mutat. Res. , vol.526 , Issue.1-2 , pp. 39-43
    • Pfeifer, G.P.1    Hainaut, P.2
  • 29
    • 20444480258 scopus 로고    scopus 로고
    • TP53 and KRAS mutation load and types in lung cancers in relation to tobacco smoke: Distinct patterns in never, former, and current smokers
    • Le Calvez F, Mukeria A, Hunt JD et al. TP53 and KRAS mutation load and types in lung cancers in relation to tobacco smoke: Distinct patterns in never, former, and current smokers. Cancer Res. 65(12), 5076-5083 (2005).
    • (2005) Cancer Res. , vol.65 , Issue.12 , pp. 5076-5083
    • Le Calvez, F.1    Mukeria, A.2    Hunt, J.D.3
  • 30
    • 0034745389 scopus 로고    scopus 로고
    • Patterns of p53 G→T transversions in lung cancers reflect the primary mutagenic signature of DNA-damage by tobacco smoke
    • Hainaut P, Pfeifer GP. Patterns of p53 G→T transversions in lung cancers reflect the primary mutagenic signature of DNA-damage by tobacco smoke. Carcinogenesis 22(3), 367-374 (2001).
    • (2001) Carcinogenesis , vol.22 , Issue.3 , pp. 367-374
    • Hainaut, P.1    Pfeifer, G.P.2
  • 31
    • 0035418259 scopus 로고    scopus 로고
    • Mutability of p53 hotspot codons to benzo(a) pyrene diol epoxide (BPDE) and the frequency of p53 mutations in nontumorous human lung
    • Hussain SP, Amstad P, Raja K et al. Mutability of p53 hotspot codons to benzo(a) pyrene diol epoxide (BPDE) and the frequency of p53 mutations in nontumorous human lung. Cancer Res. 61(17), 6350-6355 (2001).
    • (2001) Cancer Res. , vol.61 , Issue.17 , pp. 6350-6355
    • Hussain, S.P.1    Amstad, P.2    Raja, K.3
  • 32
    • 0034679057 scopus 로고    scopus 로고
    • Targeting of lung cancer mutational hotspots by polycyclic aromatic hydrocarbons
    • Smith LE, Denissenko MF, Bennett WP et al. Targeting of lung cancer mutational hotspots by polycyclic aromatic hydrocarbons. J. Natl Cancer Inst. 92(10), 803-811 (2000).
    • (2000) J. Natl Cancer Inst. , vol.92 , Issue.10 , pp. 803-811
    • Smith, L.E.1    Denissenko, M.F.2    Bennett, W.P.3
  • 33
    • 0037220167 scopus 로고    scopus 로고
    • The TP53 gene, tobacco exposure, and lung cancer
    • Toyooka S, Tsuda T, Gazdar AF. The TP53 gene, tobacco exposure, and lung cancer. Hum. Mutat. 21(3), 229-239 (2003).
    • (2003) Hum. Mutat. , vol.21 , Issue.3 , pp. 229-239
    • Toyooka, S.1    Tsuda, T.2    Gazdar, A.F.3
  • 34
    • 0034213247 scopus 로고    scopus 로고
    • P53 mutations and exposure to environmental tobacco smoke in a multicenter study on lung cancer
    • Husgafvel-Pursiainen K, Boffetta P, Kannio A et al. p53 mutations and exposure to environmental tobacco smoke in a multicenter study on lung cancer. Cancer Res. 60(11), 2906-2911 (2000).
    • (2000) Cancer Res. , vol.60 , Issue.11 , pp. 2906-2911
    • Husgafvel-Pursiainen, K.1    Boffetta, P.2    Kannio, A.3
  • 35
    • 0035361397 scopus 로고    scopus 로고
    • P53 and K-ras mutations in lung cancers from former and never-smoking women
    • Vahakangas KH, Bennett WP, Castren K et al. p53 and K-ras mutations in lung cancers from former and never-smoking women. Cancer Res. 61(11), 4350-4356 (2001).
    • (2001) Cancer Res. , vol.61 , Issue.11 , pp. 4350-4356
    • Vahakangas, K.H.1    Bennett, W.P.2    Castren, K.3
  • 36
    • 38849204971 scopus 로고    scopus 로고
    • The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity
    • Zhang S, Schafer-Hales K, Khuri FR et al. The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity. Cancer Res. 68(3), 740-748 (2008).
    • (2008) Cancer Res. , vol.68 , Issue.3 , pp. 740-748
    • Zhang, S.1    Schafer-Hales, K.2    Khuri, F.R.3
  • 37
    • 34547926839 scopus 로고    scopus 로고
    • LKB1 modulates lung cancer differentiation and metastasis
    • Ji H, Ramsey MR, Hayes DN et al. LKB1 modulates lung cancer differentiation and metastasis. Nature 448(7155), 807-810 (2007).
    • (2007) Nature , vol.448 , Issue.7155 , pp. 807-810
    • Ji, H.1    Ramsey, M.R.2    Hayes, D.N.3
  • 38
    • 45549086246 scopus 로고    scopus 로고
    • LKB1 and lung cancer: More than the usual suspects
    • Shah U, Sharpless NE, Hayes DN. LKB1 and lung cancer: More than the usual suspects. Cancer Res. 68(10), 3562-3565 (2008).
    • (2008) Cancer Res. , vol.68 , Issue.10 , pp. 3562-3565
    • Shah, U.1    Sharpless, N.E.2    Hayes, D.N.3
  • 39
    • 0042525904 scopus 로고    scopus 로고
    • LKB1 protein expression in the evolution of glandular neoplasia of the lung
    • Ghaffar H, Sahin F, Sanchez-Cepedes M et al. LKB1 protein expression in the evolution of glandular neoplasia of the lung. Clin. Cancer Res. 9(8), 2998-3003 (2003).
    • (2003) Clin. Cancer Res. , vol.9 , Issue.8 , pp. 2998-3003
    • Ghaffar, H.1    Sahin, F.2    Sanchez-Cepedes, M.3
  • 40
    • 34748845413 scopus 로고    scopus 로고
    • Prevalence and specificity of LKB1 genetic alterations in lung cancers
    • Matsumoto S, Iwakawa R, Takahashi K et al. Prevalence and specificity of LKB1 genetic alterations in lung cancers. Oncogene 26(40), 5911-5918 (2007).
    • (2007) Oncogene , vol.26 , Issue.40 , pp. 5911-5918
    • Matsumoto, S.1    Iwakawa, R.2    Takahashi, K.3
  • 41
    • 48249102662 scopus 로고    scopus 로고
    • Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients
    • Koivunen JP, Kim J, Lee J et al. Mutations in the LKB1 tumour suppressor are frequently detected in tumours from Caucasian but not Asian lung cancer patients. Br. J. Cancer 99(2), 245-252 (2008).
    • (2008) Br. J. Cancer , vol.99 , Issue.2 , pp. 245-252
    • Koivunen, J.P.1    Kim, J.2    Lee, J.3
  • 42
    • 0035266379 scopus 로고    scopus 로고
    • Increased loss of chromosome 9p21 but not p16 inactivation in primary non-small cell lung cancer from smokers
    • Sanchez-Cespedes M, Decker PA, Doffek KM et al. Increased loss of chromosome 9p21 but not p16 inactivation in primary non-small cell lung cancer from smokers. Cancer Res. 61(5), 2092-2096 (2001).
    • (2001) Cancer Res. , vol.61 , Issue.5 , pp. 2092-2096
    • Sanchez-Cespedes, M.1    Decker, P.A.2    Doffek, K.M.3
  • 43
    • 77955372895 scopus 로고    scopus 로고
    • FOXO3 encodes a carcinogen-Activated transcription factor frequently deleted in early-stage lung adenocarcinoma
    • Mikse OR, Blake DC Jr, Jones NR et al. FOXO3 encodes a carcinogen-Activated transcription factor frequently deleted in early-stage lung adenocarcinoma. Cancer Res. 70(15), 6205-6215 (2010).
    • (2010) Cancer Res. , vol.70 , Issue.15 , pp. 6205-6215
    • Mikse, O.R.1    Blake Jr., D.C.2    Jones, N.R.3
  • 44
    • 77955092315 scopus 로고    scopus 로고
    • PTEN mutations and relationship to EGFR, ERBB2, KRAS, and TP53 mutations in non-small cell lung cancers
    • Jin G, Kim MJ, Jeon HS et al. PTEN mutations and relationship to EGFR, ERBB2, KRAS, and TP53 mutations in non-small cell lung cancers. Lung Cancer 69(3), 279-283 (2009).
    • (2009) Lung Cancer , vol.69 , Issue.3 , pp. 279-283
    • Jin, G.1    Kim, M.J.2    Jeon, H.S.3
  • 45
    • 33645052711 scopus 로고    scopus 로고
    • Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features
    • Tam IY, Chung LP, Suen WS et al. Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features. Clin. Cancer Res. 12(5), 1647-1653 (2006).
    • (2006) Clin. Cancer Res. , vol.12 , Issue.5 , pp. 1647-1653
    • Tam, I.Y.1    Chung, L.P.2    Suen, W.S.3
  • 46
    • 0030894182 scopus 로고    scopus 로고
    • K-ras and p53 mutations are an independent unfavourable prognostic indicator in patients with non-small-cell lung cancer
    • Fukuyama Y, Mitsudomi T, Sugio K et al. K-ras and p53 mutations are an independent unfavourable prognostic indicator in patients with non-small-cell lung cancer. Br. J. Cancer 75(8), 1125-1130 (1997).
    • (1997) Br. J. Cancer , vol.75 , Issue.8 , pp. 1125-1130
    • Fukuyama, Y.1    Mitsudomi, T.2    Sugio, K.3
  • 47
    • 0037890342 scopus 로고    scopus 로고
    • Early glandular neoplasia of the lung
    • Westra WH. Early glandular neoplasia of the lung. Respir. Res. 1(3), 163-169 (2000).
    • (2000) Respir. Res. , vol.1 , Issue.3 , pp. 163-169
    • Westra, W.H.1
  • 48
    • 0035953550 scopus 로고    scopus 로고
    • Somatic activation of the K-ras oncogene causes early onset lung cancer in mice
    • Johnson L, Mercer K, Greenbaum D et al. Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Nature 410(6832), 1111-1116 (2001).
    • (2001) Nature , vol.410 , Issue.6832 , pp. 1111-1116
    • Johnson, L.1    Mercer, K.2    Greenbaum, D.3
  • 49
    • 42249107319 scopus 로고    scopus 로고
    • A selective small molecule inhibitor of c-Met, PHA-665752, reverses lung premalignancy induced by mutant K-ras
    • Yang Y, Wislez M, Fujimoto N et al. A selective small molecule inhibitor of c-Met, PHA-665752, reverses lung premalignancy induced by mutant K-ras. Mol. Cancer Ther. 7(4), 952-960 (2008).
    • (2008) Mol. Cancer Ther. , vol.7 , Issue.4 , pp. 952-960
    • Yang, Y.1    Wislez, M.2    Fujimoto, N.3
  • 50
    • 0036894746 scopus 로고    scopus 로고
    • BRAF and RAS mutations in human lung cancer and melanoma
    • Brose MS, Volpe P, Feldman M et al. BRAF and RAS mutations in human lung cancer and melanoma. Cancer Res. 62(23), 6997-7000 (2002).
    • (2002) Cancer Res. , vol.62 , Issue.23 , pp. 6997-7000
    • Brose, M.S.1    Volpe, P.2    Feldman, M.3
  • 51
    • 33847201454 scopus 로고    scopus 로고
    • A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors
    • Dankort D, Filenova E, Collado M et al. A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors. Genes Dev. 21(4), 379-384 (2007).
    • (2007) Genes Dev. , vol.21 , Issue.4 , pp. 379-384
    • Dankort, D.1    Filenova, E.2    Collado, M.3
  • 52
    • 79956316170 scopus 로고    scopus 로고
    • Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations
    • Paik PK, Arcila ME, Fara M et al. Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations. J. Clin. Oncol. 29(15), 2046-2051 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , Issue.15 , pp. 2046-2051
    • Paik, P.K.1    Arcila, M.E.2    Fara, M.3
  • 53
    • 70349443680 scopus 로고    scopus 로고
    • Ethnic differences and functional analysis of MET mutations in lung cancer
    • Krishnaswamy S, Kanteti R, Duke-Cohan JS et al. Ethnic differences and functional analysis of MET mutations in lung cancer. Clin. Cancer Res. 15(18), 5714-5723 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , Issue.18 , pp. 5714-5723
    • Krishnaswamy, S.1    Kanteti, R.2    Duke-Cohan, J.S.3
  • 54
    • 0015043748 scopus 로고
    • Mutation and cancer: Statistical study of retinoblastoma
    • Knudson A. Mutation and cancer: Statistical study of retinoblastoma. Proc. Natl Acad. Sci. USA 68(4), 820-823 (1971).
    • (1971) Proc. Natl Acad. Sci. USA , vol.68 , Issue.4 , pp. 820-823
    • Knudson, A.1
  • 55
    • 20344405446 scopus 로고    scopus 로고
    • DNA methylation disturbances as novel therapeutic target in lung cancer: Preclinical and clinical results
    • Digel W, Lubbert M. DNA methylation disturbances as novel therapeutic target in lung cancer: Preclinical and clinical results. Crit. Rev. Oncol. Hematol. 55(1), 1-11 (2005).
    • (2005) Crit. Rev. Oncol. Hematol. , vol.55 , Issue.1 , pp. 1-11
    • Digel, W.1    Lubbert, M.2
  • 57
    • 2442462112 scopus 로고    scopus 로고
    • Dose effect of smoking on aberrant methylation in non-small cell lung cancers
    • Toyooka S, Suzuki M, Tsuda T et al. Dose effect of smoking on aberrant methylation in non-small cell lung cancers. Int. J. Cancer 110(3), 462-464 (2004).
    • (2004) Int. J. Cancer , vol.110 , Issue.3 , pp. 462-464
    • Toyooka, S.1    Suzuki, M.2    Tsuda, T.3
  • 58
    • 0037427808 scopus 로고    scopus 로고
    • Smoke exposure, histologic type and geography-related differences in the methylation profiles of non-small cell lung cancer
    • Toyooka S, Maruyama R, Toyooka KO et al. Smoke exposure, histologic type and geography-related differences in the methylation profiles of non-small cell lung cancer. Int. J. Cancer 103(2), 153-160 (2003).
    • (2003) Int. J. Cancer , vol.103 , Issue.2 , pp. 153-160
    • Toyooka, S.1    Maruyama, R.2    Toyooka, K.O.3
  • 59
    • 0041438629 scopus 로고    scopus 로고
    • Promoter hypermethylation of the O6-methylguanine-DNA methyltransferase gene: More common in lung adenocarcinomas from never-smokers than smokers and associated with tumor progression
    • Pulling LC, Divine KK, Klinge DM et al. Promoter hypermethylation of the O6-methylguanine-DNA methyltransferase gene: More common in lung adenocarcinomas from never-smokers than smokers and associated with tumor progression. Cancer Res. 63(16), 4842-4848 (2003).
    • (2003) Cancer Res. , vol.63 , Issue.16 , pp. 4842-4848
    • Pulling, L.C.1    Divine, K.K.2    Klinge, D.M.3
  • 60
    • 33646427172 scopus 로고    scopus 로고
    • Aberrant promoter methylation of p16 and MGMT genes in lung tumors from smoking and never-smoking lung cancer patients
    • Liu Y, Lan Q, Siegfried JM, Luketich JD, Keohavong P. Aberrant promoter methylation of p16 and MGMT genes in lung tumors from smoking and never-smoking lung cancer patients. Neoplasia 8(1), 46-51 (2006).
    • (2006) Neoplasia , vol.8 , Issue.1 , pp. 46-51
    • Liu, Y.1    Lan, Q.2    Siegfried, J.M.3    Luketich, J.D.4    Keohavong, P.5
  • 61
    • 85047688675 scopus 로고    scopus 로고
    • Inactivation of hMLH1 and hMSH2 by promoter methylation in primary non-small cell lung tumors and matched sputum samples
    • Wang YC, Lu YP, Tseng RC et al. Inactivation of hMLH1 and hMSH2 by promoter methylation in primary non-small cell lung tumors and matched sputum samples. J. Clin. Invest. 111(6), 887-895 (2003).
    • (2003) J. Clin. Invest. , vol.111 , Issue.6 , pp. 887-895
    • Wang, Y.C.1    Lu, Y.P.2    Tseng, R.C.3
  • 62
    • 13844267367 scopus 로고    scopus 로고
    • DNMT3B polymorphisms and risk of primary lung cancer
    • Lee SJ, Jeon HS, Jang JS et al. DNMT3B polymorphisms and risk of primary lung cancer. Carcinogenesis 26(2), 403-409 (2005).
    • (2005) Carcinogenesis , vol.26 , Issue.2 , pp. 403-409
    • Lee, S.J.1    Jeon, H.S.2    Jang, J.S.3
  • 63
    • 33750688857 scopus 로고    scopus 로고
    • Epigenetic tete-A-tete: The bilateral relationship between chromatin modifications and DNA methylation
    • D'Alessio AC, Szyf M. Epigenetic tete-A-tete: The bilateral relationship between chromatin modifications and DNA methylation. Biochem. Cell Biol. 84(4), 463-476 (2006).
    • (2006) Biochem. Cell Biol. , vol.84 , Issue.4 , pp. 463-476
    • D'Alessio, A.C.1    Szyf, M.2
  • 64
    • 33846111256 scopus 로고    scopus 로고
    • Alteration of DNA methyltransferases contributes to 5ĆpG methylation and poor prognosis in lung cancer
    • Lin RK, Hsu HS, Chang JW et al. Alteration of DNA methyltransferases contributes to 5ĆpG methylation and poor prognosis in lung cancer. Lung Cancer 55(2), 205-213 (2007).
    • (2007) Lung Cancer , vol.55 , Issue.2 , pp. 205-213
    • Lin, R.K.1    Hsu, H.S.2    Chang, J.W.3
  • 65
    • 34250633214 scopus 로고    scopus 로고
    • Utilization of chromatin remodeling agents for lung cancer therapy
    • Schrump DS, Hong JA, Nguyen DM. Utilization of chromatin remodeling agents for lung cancer therapy. Cancer J. 13(1), 56-64 (2007).
    • (2007) Cancer J. , vol.13 , Issue.1 , pp. 56-64
    • Schrump, D.S.1    Hong, J.A.2    Nguyen, D.M.3
  • 66
    • 0030006213 scopus 로고    scopus 로고
    • Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer
    • Belinsky SA, Nikula KJ, Baylin SB, Issa JP. Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer. Proc. Natl Acad. Sci. USA 93(9), 4045-4050 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , Issue.9 , pp. 4045-4050
    • Belinsky, S.A.1    Nikula, K.J.2    Baylin, S.B.3    Issa, J.P.4
  • 67
    • 43649106748 scopus 로고    scopus 로고
    • Expression of methylation-related genes is associated with overall survival in patients with non-small cell lung cancer
    • Xing J, Stewart DJ, Gu J et al. Expression of methylation-related genes is associated with overall survival in patients with non-small cell lung cancer. Br. J. Cancer 98(10), 1716-1722 (2008).
    • (2008) Br. J. Cancer , vol.98 , Issue.10 , pp. 1716-1722
    • Xing, J.1    Stewart, D.J.2    Gu, J.3
  • 68
    • 77954086478 scopus 로고    scopus 로고
    • Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate
    • Indicates that cigarette smoke induces 'cancer-Associated' epigenomic alterations in cultured respiratory epithelia
    • Liu F, Killian JK, Yang M et al. Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate. Oncogene 29(25), 3650-3664 (2010). Indicates that cigarette smoke induces 'cancer-Associated' epigenomic alterations in cultured respiratory epithelia.
    • (2010) Oncogene , vol.29 , Issue.25 , pp. 3650-3664
    • Liu, F.1    Killian, J.K.2    Yang, M.3
  • 69
    • 58149329023 scopus 로고    scopus 로고
    • Loss of histone H4K20 trimethylation occurs in preneoplasia and influences prognosis of non-small cell lung cancer
    • Van Den Broeck A, Brambilla E, Moro-Sibilot D et al. Loss of histone H4K20 trimethylation occurs in preneoplasia and influences prognosis of non-small cell lung cancer. Clin. Cancer Res. 14(22), 7237-7245 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , Issue.22 , pp. 7237-7245
    • Van Den Broeck, A.1    Brambilla, E.2    Moro-Sibilot, D.3
  • 70
    • 65949116604 scopus 로고    scopus 로고
    • Tobacco smoke induces polycomb-mediated repression of Dickkopf-1 in lung cancer cells
    • Provides evidence that cigarette smoke directly engages polycomb machinery to activate a signaling network implicated in maintenance of cancer stem cells
    • Hussain M, Rao M, Humphries AE et al. Tobacco smoke induces polycomb-mediated repression of Dickkopf-1 in lung cancer cells. Cancer Res. 69(8), 3570-3578 (2009). Provides evidence that cigarette smoke directly engages polycomb machinery to activate a signaling network implicated in maintenance of cancer stem cells.
    • (2009) Cancer Res. , vol.69 , Issue.8 , pp. 3570-3578
    • Hussain, M.1    Rao, M.2    Humphries, A.E.3
  • 71
    • 59349117680 scopus 로고    scopus 로고
    • Epigenetic mediated transcriptional activation of WNT5A participates in arsenical-Associated malignant transformation
    • Jensen TJ, Wozniak RJ, Eblin KE et al. Epigenetic mediated transcriptional activation of WNT5A participates in arsenical-Associated malignant transformation. Toxicol. Appl. Pharmacol. 235(1), 39-46 (2009).
    • (2009) Toxicol. Appl. Pharmacol. , vol.235 , Issue.1 , pp. 39-46
    • Jensen, T.J.1    Wozniak, R.J.2    Eblin, K.E.3
  • 72
    • 61849137246 scopus 로고    scopus 로고
    • Effects of nickel, chromate, and arsenite on histone 3 lysine methylation
    • Zhou X, Li Q, Arita A, Sun H, Costa M. Effects of nickel, chromate, and arsenite on histone 3 lysine methylation. Toxicol. Appl. Pharmacol. 236(1), 78-84 (2009).
    • (2009) Toxicol. Appl. Pharmacol. , vol.236 , Issue.1 , pp. 78-84
    • Zhou, X.1    Li, Q.2    Arita, A.3    Sun, H.4    Costa, M.5
  • 73
    • 32944468706 scopus 로고    scopus 로고
    • Mutational and epigenetic evidence for independent pathways for lung adenocarcinomas arising in smokers and never smokers
    • Toyooka S, Tokumo M, Shigematsu H et al. Mutational and epigenetic evidence for independent pathways for lung adenocarcinomas arising in smokers and never smokers. Cancer Res. 66(3), 1371-1375 (2006).
    • (2006) Cancer Res. , vol.66 , Issue.3 , pp. 1371-1375
    • Toyooka, S.1    Tokumo, M.2    Shigematsu, H.3
  • 74
    • 70349174971 scopus 로고    scopus 로고
    • The RASSF proteins in cancer; from epigenetic silencing to functional characterization
    • Richter AM, Pfeifer GP, Dammann RH. The RASSF proteins in cancer; from epigenetic silencing to functional characterization. Biochim. Biophys. Acta 1796(2), 114-128 (2009).
    • (2009) Biochim. Biophys. Acta , vol.1796 , Issue.2 , pp. 114-128
    • Richter, A.M.1    Pfeifer, G.P.2    Dammann, R.H.3
  • 75
    • 55349109940 scopus 로고    scopus 로고
    • Carcinogen-induced gene promoter hypermethylation is mediated by DNMT1 and causal for transformation of immortalized bronchial epithelial cells
    • This finding supports the development of demethylation strategies for primary prevention of lung cancer in smokers
    • Damiani LA, Yingling CM, Leng S et al. Carcinogen-induced gene promoter hypermethylation is mediated by DNMT1 and causal for transformation of immortalized bronchial epithelial cells. Cancer Res. 68(21), 9005-9014 (2008). This finding supports the development of demethylation strategies for primary prevention of lung cancer in smokers.
    • (2008) Cancer Res. , vol.68 , Issue.21 , pp. 9005-9014
    • Damiani, L.A.1    Yingling, C.M.2    Leng, S.3
  • 76
    • 1842426642 scopus 로고    scopus 로고
    • Detection of promoter hypermethylation of multiple genes in the tumor and bronchoalveolar lavage of patients with lung cancer
    • Topaloglu O, Hoque MO, Tokumaru Y et al. Detection of promoter hypermethylation of multiple genes in the tumor and bronchoalveolar lavage of patients with lung cancer. Clin. Cancer Res. 10(7), 2284-2288 (2004).
    • (2004) Clin. Cancer Res. , vol.10 , Issue.7 , pp. 2284-2288
    • Topaloglu, O.1    Hoque, M.O.2    Tokumaru, Y.3
  • 77
    • 33749986298 scopus 로고    scopus 로고
    • Free radicals and antioxidants in normal physiological functions and human disease
    • Valko M, Leibfritz D, Moncol J et al. Free radicals and antioxidants in normal physiological functions and human disease. Int. J. Biochem. Cell Biol. 39(1), 44-84 (2007).
    • (2007) Int. J. Biochem. Cell Biol. , vol.39 , Issue.1 , pp. 44-84
    • Valko, M.1    Leibfritz, D.2    Moncol, J.3
  • 78
    • 38149013206 scopus 로고    scopus 로고
    • Time-dependent formation of 8-oxo-deoxyguanosine in the lungs of mice exposed to cigarette smoke
    • Thaiparambil JT, Vadhanam MV, Srinivasan C, Gairola CG, Gupta RC. Time-dependent formation of 8-oxo-deoxyguanosine in the lungs of mice exposed to cigarette smoke. Chem. Res. Toxicol. 20(12), 1737-1740 (2007).
    • (2007) Chem. Res. Toxicol. , vol.20 , Issue.12 , pp. 1737-1740
    • Thaiparambil, J.T.1    Vadhanam, M.V.2    Srinivasan, C.3    Gairola, C.G.4    Gupta, R.C.5
  • 79
    • 4043062803 scopus 로고    scopus 로고
    • Acute effects of cigarette smoke on inflammation and oxidative stress: A review
    • van der Vaart H, Postma DS, Timens W, ten Hacken NH. Acute effects of cigarette smoke on inflammation and oxidative stress: A review. Thorax 59(8), 713-721 (2004).
    • (2004) Thorax , vol.59 , Issue.8 , pp. 713-721
    • Van Der Vaart, H.1    Postma, D.S.2    Timens, W.3    Ten Hacken, N.H.4
  • 80
    • 67349186983 scopus 로고    scopus 로고
    • How cigarette smoke skews immune responses to promote infection, lung disease and cancer
    • Stampfli MR, Anderson GP. How cigarette smoke skews immune responses to promote infection, lung disease and cancer. Nat. Rev. Immunol. 9(5), 377-384 (2009).
    • (2009) Nat. Rev. Immunol. , vol.9 , Issue.5 , pp. 377-384
    • Stampfli, M.R.1    Anderson, G.P.2
  • 81
    • 33744780420 scopus 로고    scopus 로고
    • Antioxidant therapeutic targets in COPD
    • Rahman I, Kilty I. Antioxidant therapeutic targets in COPD. Curr. Drug Targets 7(6), 707-720 (2006).
    • (2006) Curr. Drug Targets , vol.7 , Issue.6 , pp. 707-720
    • Rahman, I.1    Kilty, I.2
  • 82
    • 22844439423 scopus 로고    scopus 로고
    • Effect of smoke shield-A herbal formulation on the mutagenicity and oxidative stress produced by cigarette smoke in rats
    • Swarnam J, Sreekanth KS, Hareesh P, Sabu MC, Kuttan R. Effect of smoke shield-A herbal formulation on the mutagenicity and oxidative stress produced by cigarette smoke in rats. J. Exp. Clin. Cancer Res. 24(2), 297-304 (2005).
    • (2005) J. Exp. Clin. Cancer Res. , vol.24 , Issue.2 , pp. 297-304
    • Swarnam, J.1    Sreekanth, K.S.2    Hareesh, P.3    Sabu, M.C.4    Kuttan, R.5
  • 83
    • 0032993093 scopus 로고    scopus 로고
    • Increased glutathione and glutathione peroxidase in lungs of individuals with chronic beryllium disease
    • Comhair SA, Lewis MJ, Bhathena PR, Hammel JP, Erzurum SC. Increased glutathione and glutathione peroxidase in lungs of individuals with chronic beryllium disease. Am. J. Respir. Crit. Care Med. 159(6), 1824-1829 (1999).
    • (1999) Am. J. Respir. Crit. Care Med. , vol.159 , Issue.6 , pp. 1824-1829
    • Comhair, S.A.1    Lewis, M.J.2    Bhathena, P.R.3    Hammel, J.P.4    Erzurum, S.C.5
  • 84
    • 5344261085 scopus 로고    scopus 로고
    • Nicotine could augment adhesion molecule expression in human endothelial cells through macrophages secreting TNF-A, IL-1b
    • Wang Y, Wang L, Ai X et al. Nicotine could augment adhesion molecule expression in human endothelial cells through macrophages secreting TNF-A, IL-1b. Int. Immunopharmacol. 4(13), 1675-1686 (2004).
    • (2004) Int. Immunopharmacol. , vol.4 , Issue.13 , pp. 1675-1686
    • Wang, Y.1    Wang, L.2    Ai, X.3
  • 85
    • 0033773688 scopus 로고    scopus 로고
    • Balance of matrix metalloprotease-9 and tissue inhibitor of metalloprotease-1 from alveolar macrophages in cigarette smokers. Regulation by interleukin-10
    • Lim S, Roche N, Oliver BG et al. Balance of matrix metalloprotease-9 and tissue inhibitor of metalloprotease-1 from alveolar macrophages in cigarette smokers. Regulation by interleukin-10. Am. J. Respir. Crit. Care Med. 162(4 pt 1), 1355-1360 (2000).
    • (2000) Am. J. Respir. Crit. Care Med. , vol.162 , Issue.4 PART 1 , pp. 1355-1360
    • Lim, S.1    Roche, N.2    Oliver, B.G.3
  • 86
    • 0033836240 scopus 로고    scopus 로고
    • Suppression of human IL-1b, IL-2, IFN-g, and TNF-Aproduction by cigarette smoke extracts
    • Ouyang Y, Virasch N, Hao P et al. Suppression of human IL-1b, IL-2, IFN-g, and TNF-Aproduction by cigarette smoke extracts. J. Allergy Clin. Immunol. 106(2), 280-287 (2000).
    • (2000) J. Allergy Clin. Immunol. , vol.106 , Issue.2 , pp. 280-287
    • Ouyang, Y.1    Virasch, N.2    Hao, P.3
  • 87
    • 11144241805 scopus 로고    scopus 로고
    • Matrix metalloproteinase/epidermal growth factor receptor/mitogen- Activated protein kinase signaling regulate fra-1 induction by cigarette smoke in lung epithelial cells
    • Zhang Q, Adiseshaiah P, Reddy SP. Matrix metalloproteinase/epidermal growth factor receptor/mitogen-Activated protein kinase signaling regulate fra-1 induction by cigarette smoke in lung epithelial cells. Am. J. Respir. Cell Mol. Biol. 32(1), 72-81 (2005).
    • (2005) Am. J. Respir. Cell Mol. Biol. , vol.32 , Issue.1 , pp. 72-81
    • Zhang, Q.1    Adiseshaiah, P.2    Reddy, S.P.3
  • 88
    • 9144246960 scopus 로고    scopus 로고
    • Nicotine enhances angiotensin II-induced mitogenic response in vascular smooth muscle cells and fibroblasts
    • Li JM, Cui TX, Shiuchi T et al. Nicotine enhances angiotensin II-induced mitogenic response in vascular smooth muscle cells and fibroblasts. Arterioscler. Thromb. Vasc. Biol. 24(1), 80-84 (2004).
    • (2004) Arterioscler. Thromb. Vasc. Biol. , vol.24 , Issue.1 , pp. 80-84
    • Li, J.M.1    Cui, T.X.2    Shiuchi, T.3
  • 89
    • 0035294522 scopus 로고    scopus 로고
    • Differential activation of MAP kinase signaling pathways and nuclear factor-kB in bronchoalveolar cells of smokers and nonsmokers
    • Mochida-Nishimura K, Surewicz K, Cross JV et al. Differential activation of MAP kinase signaling pathways and nuclear factor-kB in bronchoalveolar cells of smokers and nonsmokers. Mol. Med. 7(3), 177-185 (2001).
    • (2001) Mol. Med. , vol.7 , Issue.3 , pp. 177-185
    • Mochida-Nishimura, K.1    Surewicz, K.2    Cross, J.V.3
  • 90
    • 0037251810 scopus 로고    scopus 로고
    • Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells
    • West KA, Brognard J, Clark AS et al. Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. J. Clin. Invest. 111(1), 81-90 (2003).
    • (2003) J. Clin. Invest. , vol.111 , Issue.1 , pp. 81-90
    • West, K.A.1    Brognard, J.2    Clark, A.S.3
  • 91
    • 1642434133 scopus 로고    scopus 로고
    • Tobacco carcinogen-induced cellular transformation increases activation of the phosphatidylinositol 3́-kinase/Akt pathway in vitro and in vivo
    • West KA, Linnoila IR, Belinsky SA, Harris CC, Dennis PA. Tobacco carcinogen-induced cellular transformation increases activation of the phosphatidylinositol 3́-kinase/Akt pathway in vitro and in vivo. Cancer Res. 64(2), 446-451 (2004).
    • (2004) Cancer Res. , vol.64 , Issue.2 , pp. 446-451
    • West, K.A.1    Linnoila, I.R.2    Belinsky, S.A.3    Harris, C.C.4    Dennis, P.A.5
  • 92
    • 21344464734 scopus 로고    scopus 로고
    • Tobacco components stimulate Akt-dependent proliferation and NFkB-dependent survival in lung cancer cells
    • Tsurutani J, Castillo SS, Brognard J et al. Tobacco components stimulate Akt-dependent proliferation and NFkB-dependent survival in lung cancer cells. Carcinogenesis 26(7), 1182-1195 (2005).
    • (2005) Carcinogenesis , vol.26 , Issue.7 , pp. 1182-1195
    • Tsurutani, J.1    Castillo, S.S.2    Brognard, J.3
  • 93
    • 77958516991 scopus 로고    scopus 로고
    • MicroRNA-218 is deleted and downregulated in lung squamous cell carcinoma
    • Davidson MR, Larsen JE, Yang IA et al. MicroRNA-218 is deleted and downregulated in lung squamous cell carcinoma. PLoS One 5(90), e12560 (2010).
    • (2010) PLoS One , vol.5 , Issue.90
    • Davidson, M.R.1    Larsen, J.E.2    Yang, I.A.3
  • 94
    • 60549084170 scopus 로고    scopus 로고
    • MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium
    • MicroRNA profiles obtained from this study may serve as biomarkers for smoking-related lung diseases and help elucidate the regulatory mechanisms that mediate the host response to tobacco smoke exposure and other environmental agents
    • Schembri F, Sridhar S, Perdomo C et al. MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium. Proc. Natl Acad. Sci. USA 106(7), 2319-2324 (2009). MicroRNA profiles obtained from this study may serve as biomarkers for smoking-related lung diseases and help elucidate the regulatory mechanisms that mediate the host response to tobacco smoke exposure and other environmental agents.
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , Issue.7 , pp. 2319-2324
    • Schembri, F.1    Sridhar, S.2    Perdomo, C.3
  • 95
    • 78349309212 scopus 로고    scopus 로고
    • Expression of miRNA-130a in nonsmall cell lung cancer
    • Wang XC, Tian LL, Wu HL et al. Expression of miRNA-130a in nonsmall cell lung cancer. Am. J. Med. Sci. 340(5), 385-388 (2010).
    • (2010) Am. J. Med. Sci. , vol.340 , Issue.5 , pp. 385-388
    • Wang, X.C.1    Tian, L.L.2    Wu, H.L.3
  • 96
    • 77954315239 scopus 로고    scopus 로고
    • Deregulated expression of miR-21, miR-143 and miR-181a in non small cell lung cancer is related to clinicopathologic characteristics or patient prognosis
    • Gao W, Yu Y, Cao H et al. Deregulated expression of miR-21, miR-143 and miR-181a in non small cell lung cancer is related to clinicopathologic characteristics or patient prognosis. Biomed. Pharmacother. 64(6), 399-408 (2010).
    • (2010) Biomed. Pharmacother. , vol.64 , Issue.6 , pp. 399-408
    • Gao, W.1    Yu, Y.2    Cao, H.3
  • 97
    • 74549121893 scopus 로고    scopus 로고
    • MicroRNA expression differentiates histology and predicts survival of lung cancer
    • Landi MT, Zhao Y, Rotunno M et al. MicroRNA expression differentiates histology and predicts survival of lung cancer. Clin. Cancer Res. 16(2), 430-441 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , Issue.2 , pp. 430-441
    • Landi, M.T.1    Zhao, Y.2    Rotunno, M.3
  • 98
    • 61449208911 scopus 로고    scopus 로고
    • Downregulation of microRNA expression in the lungs of rats exposed to cigarette smoke
    • Izzotti A, Calin GA, Arrigo P et al. Downregulation of microRNA expression in the lungs of rats exposed to cigarette smoke. FASEB J. 23(3), 806-812 (2009).
    • (2009) FASEB J. , vol.23 , Issue.3 , pp. 806-812
    • Izzotti, A.1    Calin, G.A.2    Arrigo, P.3
  • 99
    • 35348864988 scopus 로고    scopus 로고
    • The impact of sex and smoking status on the mutational spectrum of epidermal growth factor receptor gene in non small cell lung cancer
    • Toyooka S, Matsuo K, Shigematsu H et al. The impact of sex and smoking status on the mutational spectrum of epidermal growth factor receptor gene in non small cell lung cancer. Clin. Cancer Res. 13(19), 5763-5768 (2007).
    • (2007) Clin. Cancer Res. , vol.13 , Issue.19 , pp. 5763-5768
    • Toyooka, S.1    Matsuo, K.2    Shigematsu, H.3
  • 100
    • 41649103052 scopus 로고    scopus 로고
    • A variant associated with nicotine dependence, lung cancer and peripheral arterial disease
    • Thorgeirsson TE, Geller F, Sulem P et al. A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature 452(7187), 638-642 (2008).
    • (2008) Nature , vol.452 , Issue.7187 , pp. 638-642
    • Thorgeirsson, T.E.1    Geller, F.2    Sulem, P.3
  • 101
    • 41649103682 scopus 로고    scopus 로고
    • A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25
    • Hung RJ, McKay JD, Gaborieau V et al. A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature 452(7187), 633-637 (2008).
    • (2008) Nature , vol.452 , Issue.7187 , pp. 633-637
    • Hung, R.J.1    McKay, J.D.2    Gaborieau, V.3
  • 102
    • 56749182096 scopus 로고    scopus 로고
    • Lung cancer susceptibility locus at 5p15.33
    • McKay JD, Hung RJ, Gaborieau V et al. Lung cancer susceptibility locus at 5p15.33. Nat. Genet. 40(12), 1404-1406 (2008).
    • (2008) Nat. Genet. , vol.40 , Issue.12 , pp. 1404-1406
    • McKay, J.D.1    Hung, R.J.2    Gaborieau, V.3
  • 103
    • 42649091460 scopus 로고    scopus 로고
    • Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1
    • Amos CI, Wu X, Broderick P et al. Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nat. Genet. 40(5), 616-622 (2008).
    • (2008) Nat. Genet. , vol.40 , Issue.5 , pp. 616-622
    • Amos, C.I.1    Wu, X.2    Broderick, P.3
  • 104
    • 0042566080 scopus 로고    scopus 로고
    • Lung cancer risk in germline p53 mutation carriers: Association between an inherited cancer predisposition, cigarette smoking, and cancer risk
    • Hwang SJ, Cheng LS, Lozano G et al. Lung cancer risk in germline p53 mutation carriers: Association between an inherited cancer predisposition, cigarette smoking, and cancer risk. Hum. Genet. 113(3), 238-243 (2003).
    • (2003) Hum. Genet. , vol.113 , Issue.3 , pp. 238-243
    • Hwang, S.J.1    Cheng, L.S.2    Lozano, G.3
  • 105
    • 33847749502 scopus 로고    scopus 로고
    • Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer
    • Indicates that gene expression in cytologically normal large-Airway epithelial cells can serve as a lung cancer biomarker, potentially owing to a cancer-specific airway-wide response to cigarette smoke
    • Spira A, Beane JE, Shah V et al. Airway epithelial gene expression in the diagnostic evaluation of smokers with suspect lung cancer. Nat. Med. 13(3), 361-366 (2007). Indicates that gene expression in cytologically normal large-Airway epithelial cells can serve as a lung cancer biomarker, potentially owing to a cancer-specific airway-wide response to cigarette smoke.
    • (2007) Nat. Med. , vol.13 , Issue.3 , pp. 361-366
    • Spira, A.1    Beane, J.E.2    Shah, V.3
  • 106
    • 0036606009 scopus 로고    scopus 로고
    • Laser capture microdissection and microarray expression analysis of lung adenocarcinoma reveals tobacco smoking- and prognosis-related molecular profiles
    • Miura K, Bowman ED, Simon R et al. Laser capture microdissection and microarray expression analysis of lung adenocarcinoma reveals tobacco smoking- and prognosis-related molecular profiles. Cancer Res. 62(11), 3244-3250 (2002).
    • (2002) Cancer Res. , vol.62 , Issue.11 , pp. 3244-3250
    • Miura, K.1    Bowman, E.D.2    Simon, R.3
  • 107
    • 0027993707 scopus 로고
    • Efficacy and safety profile of gemcitabine in non-small-cell lung cancer: A Phase 2 study
    • Abratt RP, Bezwoda WR, Falkson G et al. Efficacy and safety profile of gemcitabine in non-small-cell lung cancer: A Phase 2 study. J. Clin. Oncol. 12(8), 1535-1540 (1994).
    • (1994) J. Clin. Oncol. , vol.12 , Issue.8 , pp. 1535-1540
    • Abratt, R.P.1    Bezwoda, W.R.2    Falkson, G.3
  • 108
    • 0034327412 scopus 로고    scopus 로고
    • The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: Identification and evaluation of the resident candidate tumor suppressor genes. The international lung cancer chromosome 3p21.3 tumor suppressor gene consortium
    • Lerman MI, Minna JD. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: Identification and evaluation of the resident candidate tumor suppressor genes. The international lung cancer chromosome 3p21.3 tumor suppressor gene consortium. Cancer Res. 60(21), 6116-6133 (2000).
    • (2000) Cancer Res. , vol.60 , Issue.21 , pp. 6116-6133
    • Lerman, M.I.1    Minna, J.D.2
  • 109
    • 34250890852 scopus 로고    scopus 로고
    • Smokers and passive smokers gene expression profiles: Correlation with the DNA oxidation damage
    • Lodovici M, Luceri C, De Filippo C et al. Smokers and passive smokers gene expression profiles: Correlation with the DNA oxidation damage. Free Radic. Biol. Med. 43(3), 415-422 (2007).
    • (2007) Free Radic. Biol. Med. , vol.43 , Issue.3 , pp. 415-422
    • Lodovici, M.1    Luceri, C.2    De Filippo, C.3
  • 110
    • 0037423930 scopus 로고    scopus 로고
    • Conserved histone variant H2A.Z protects euchromatin from the ectopic spread of silent heterochromatin
    • Meneghini MD, Wu M, Madhani HD. Conserved histone variant H2A.Z protects euchromatin from the ectopic spread of silent heterochromatin. Cell 112(5), 725-736 (2003).
    • (2003) Cell , vol.112 , Issue.5 , pp. 725-736
    • Meneghini, M.D.1    Wu, M.2    Madhani, H.D.3
  • 111
    • 10044241543 scopus 로고    scopus 로고
    • Oxidative stress and cigarette smoke alter chromatin remodeling but differentially regulate NF-kB activation and proinflammatory cytokine release in alveolar epithelial cells
    • Demonstrates alterations of key pathways by cigarette smoke
    • Moodie FM, Marwick JA, Anderson CS et al. Oxidative stress and cigarette smoke alter chromatin remodeling but differentially regulate NF-kB activation and proinflammatory cytokine release in alveolar epithelial cells. FASEB J. 18(15), 1897-1899 (2004). Demonstrates alterations of key pathways by cigarette smoke.
    • (2004) FASEB J. , vol.18 , Issue.15 , pp. 1897-1899
    • Moodie, F.M.1    Marwick, J.A.2    Anderson, C.S.3
  • 112
    • 0033853546 scopus 로고    scopus 로고
    • Nicotine reorganizes cytoskeleton of vascular endothelial cell through platelet-derived growth factor BB
    • Cucina A, Sapienza P, Borrelli V et al. Nicotine reorganizes cytoskeleton of vascular endothelial cell through platelet-derived growth factor BB. J. Surg. Res. 92(2), 233-238 (2000).
    • (2000) J. Surg. Res. , vol.92 , Issue.2 , pp. 233-238
    • Cucina, A.1    Sapienza, P.2    Borrelli, V.3
  • 113
    • 0033855942 scopus 로고    scopus 로고
    • The relative toxicity of compounds in mainstream cigarette smoke condensate
    • Smith CJ, Hansch C. The relative toxicity of compounds in mainstream cigarette smoke condensate. Food Chem. Toxicol. 38(7), 637-646 (2000).
    • (2000) Food Chem. Toxicol. , vol.38 , Issue.7 , pp. 637-646
    • Smith, C.J.1    Hansch, C.2
  • 114
    • 47249165575 scopus 로고    scopus 로고
    • Nicotine primarily suppresses lung Th2 but not goblet cell and muscle cell responses to allergens
    • Mishra NC, Rir-Sima-Ah J, Langley RJ et al. Nicotine primarily suppresses lung Th2 but not goblet cell and muscle cell responses to allergens. J. Immunol. 180(11), 7655-7663 (2008).
    • (2008) J. Immunol. , vol.180 , Issue.11 , pp. 7655-7663
    • Mishra, N.C.1    Rir-Sima-Ah, J.2    Langley, R.J.3
  • 115
    • 33847787624 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor gene polymorphisms affect lung cancer risk
    • Kim JH, Kim H, Lee KY et al. Aryl hydrocarbon receptor gene polymorphisms affect lung cancer risk. Lung Cancer 56(1), 9-15 (2007).
    • (2007) Lung Cancer , vol.56 , Issue.1 , pp. 9-15
    • Kim, J.H.1    Kim, H.2    Lee, K.Y.3
  • 116
    • 61449417240 scopus 로고    scopus 로고
    • Heme oxygenase-1 and carbon monoxide: Emerging therapeutic targets in inflammation and allergy
    • Pae HO, Lee YC, Chung HT. Heme oxygenase-1 and carbon monoxide: Emerging therapeutic targets in inflammation and allergy. Recent Pat. Inflamm. Allergy Drug Discov. 2(3), 159-165 (2008).
    • (2008) Recent Pat. Inflamm. Allergy Drug Discov. , vol.2 , Issue.3 , pp. 159-165
    • Pae, H.O.1    Lee, Y.C.2    Chung, H.T.3
  • 117
    • 0037102347 scopus 로고    scopus 로고
    • 4-Hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease
    • Rahman I, van Schadewijk AA, Crowther AJ et al. 4-Hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 166(4), 490-495 (2002).
    • (2002) Am. J. Respir. Crit. Care Med. , vol.166 , Issue.4 , pp. 490-495
    • Rahman, I.1    Van Schadewijk, A.A.2    Crowther, A.J.3
  • 118
    • 28644451208 scopus 로고    scopus 로고
    • Expression and carbonylation of creatine kinase in the quadriceps femoris muscles of patients with chronic obstructive pulmonary disease
    • Barreiro E, Gea J, Matar G, Hussain SN. Expression and carbonylation of creatine kinase in the quadriceps femoris muscles of patients with chronic obstructive pulmonary disease. Am. J. Respir. Cell Mol. Biol. 33(6), 636-642 (2005).
    • (2005) Am. J. Respir. Cell Mol. Biol. , vol.33 , Issue.6 , pp. 636-642
    • Barreiro, E.1    Gea, J.2    Matar, G.3    Hussain, S.N.4
  • 119
    • 60749101452 scopus 로고    scopus 로고
    • Is cancer triggered by altered signalling of nicotinic acetylcholine receptors?
    • Schuller HM. Is cancer triggered by altered signalling of nicotinic acetylcholine receptors? Nat. Rev. Cancer 9(3), 195-205 (2009).
    • (2009) Nat. Rev. Cancer , vol.9 , Issue.3 , pp. 195-205
    • Schuller, H.M.1
  • 120
    • 0037152628 scopus 로고    scopus 로고
    • Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-Associated cancers
    • Pfeifer GP, Denissenko MF, Olivier M et al. Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-Associated cancers. Oncogene 21(48), 7435-7451 (2002).
    • (2002) Oncogene , vol.21 , Issue.48 , pp. 7435-7451
    • Pfeifer, G.P.1    Denissenko, M.F.2    Olivier, M.3
  • 121
    • 0032080899 scopus 로고    scopus 로고
    • Chromosome 3p14 alterations in lung cancer: Evidence that FHIT exon deletion is a target of tobacco carcinogens and asbestos
    • Nelson HH, Wiencke JK, Gunn L et al. Chromosome 3p14 alterations in lung cancer: Evidence that FHIT exon deletion is a target of tobacco carcinogens and asbestos. Cancer Res. 58(9), 1804-1807 (1998).
    • (1998) Cancer Res. , vol.58 , Issue.9 , pp. 1804-1807
    • Nelson, H.H.1    Wiencke, J.K.2    Gunn, L.3
  • 122
    • 0028143078 scopus 로고
    • Difference of allelotype between squamous cell carcinoma and adenocarcinoma of the lung
    • Sato S, Nakamura Y, Tsuchiya E. Difference of allelotype between squamous cell carcinoma and adenocarcinoma of the lung. Cancer Res. 54(21), 5652-5655 (1994).
    • (1994) Cancer Res. , vol.54 , Issue.21 , pp. 5652-5655
    • Sato, S.1    Nakamura, Y.2    Tsuchiya, E.3
  • 123
    • 78651306122 scopus 로고    scopus 로고
    • LKB1 gene alterations in surgically resectable adenocarcinoma of the lung
    • Okuda K, Sasaki H, Hikosaka Y et al. LKB1 gene alterations in surgically resectable adenocarcinoma of the lung. Surg. Today 41(1), 107-110 (2010).
    • (2010) Surg. Today , vol.41 , Issue.1 , pp. 107-110
    • Okuda, K.1    Sasaki, H.2    Hikosaka, Y.3
  • 124
    • 34848869989 scopus 로고    scopus 로고
    • Genetic pathways and mutation profiles of human cancers: Site- and exposure-specific patterns
    • Lea IA, Jackson MA, Li X et al. Genetic pathways and mutation profiles of human cancers: Site- and exposure-specific patterns. Carcinogenesis 28(9), 1851-1858 (2007).
    • (2007) Carcinogenesis , vol.28 , Issue.9 , pp. 1851-1858
    • Lea, I.A.1    Jackson, M.A.2    Li, X.3
  • 125
    • 0035863510 scopus 로고    scopus 로고
    • Tobacco smoke-induced DNA damage and an early age of smoking initiation induce chromosome loss at 3p21 in lung cancer
    • Hirao T, Nelson HH, Ashok TD et al. Tobacco smoke-induced DNA damage and an early age of smoking initiation induce chromosome loss at 3p21 in lung cancer. Cancer Res. 61(2), 612-615 (2001).
    • (2001) Cancer Res. , vol.61 , Issue.2 , pp. 612-615
    • Hirao, T.1    Nelson, H.H.2    Ashok, T.D.3
  • 126
    • 79956115427 scopus 로고    scopus 로고
    • Inverse correlation between EGFR mutation and FHIT, RASSF1A and RUNX3 methylation in lung adenocarcinoma: Relation with smoking status
    • Yanagawa N, Tamura G, Oizumi H et al. Inverse correlation between EGFR mutation and FHIT, RASSF1A and RUNX3 methylation in lung adenocarcinoma: Relation with smoking status. Anticancer Res. 31(4), 1211-1214 (2011).
    • (2011) Anticancer Res. , vol.31 , Issue.4 , pp. 1211-1214
    • Yanagawa, N.1    Tamura, G.2    Oizumi, H.3
  • 127
    • 77449124527 scopus 로고    scopus 로고
    • PTEN, RASSF1 and DAPK site-specific hypermethylation and outcome in surgically treated Stage 1 and 2 nonsmall cell lung cancer patients
    • Buckingham L, Penfield Faber L, Kim A et al. PTEN, RASSF1 and DAPK site-specific hypermethylation and outcome in surgically treated Stage 1 and 2 nonsmall cell lung cancer patients. Int. J. Cancer 126(7), 1630-1639 (2010).
    • (2010) Int. J. Cancer , vol.126 , Issue.7 , pp. 1630-1639
    • Buckingham, L.1    Penfield Faber, L.2    Kim, A.3
  • 128
    • 74549167140 scopus 로고    scopus 로고
    • Methylation induced gene silencing of HtrA3 in smoking-related lung cancer
    • Beleford D, Liu Z, Rattan R et al. Methylation induced gene silencing of HtrA3 in smoking-related lung cancer. Clin. Cancer Res. 16(2), 398-409 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , Issue.2 , pp. 398-409
    • Beleford, D.1    Liu, Z.2    Rattan, R.3
  • 129
    • 33646343483 scopus 로고    scopus 로고
    • The methylation status and protein expression of CDH1, p16 (INK4A), and fragile histidine triad in nonsmall cell lung carcinoma: Epigenetic silencing, clinical features, and prognostic significance
    • Nakata S, Sugio K, Uramoto H et al. The methylation status and protein expression of CDH1, p16 (INK4A), and fragile histidine triad in nonsmall cell lung carcinoma: Epigenetic silencing, clinical features, and prognostic significance. Cancer 106(10), 2190-2199 (2006).
    • (2006) Cancer , vol.106 , Issue.10 , pp. 2190-2199
    • Nakata, S.1    Sugio, K.2    Uramoto, H.3
  • 130
    • 33646021646 scopus 로고    scopus 로고
    • Hypermethylation of the TSLC1/IGSF4 promoter is associated with tobacco smoking and a poor prognosis in primary nonsmall cell lung carcinoma
    • Kikuchi S, Yamada D, Fukami T et al. Hypermethylation of the TSLC1/IGSF4 promoter is associated with tobacco smoking and a poor prognosis in primary nonsmall cell lung carcinoma. Cancer 106(8), 1751-1758 (2006).
    • (2006) Cancer , vol.106 , Issue.8 , pp. 1751-1758
    • Kikuchi, S.1    Yamada, D.2    Fukami, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.