Suppression of human IL-1β, IL-2, IFN-γ, and TNF-α production by cigarette smoke extracts

Journal of Allergy and Clinical Immunology

Volumn 106, Issue 2, 2000, Pages 280-287

  Ouyang, Yanli ^a   Virasch, Nisha ^a   Hao, Ping ^a   Aubrey, Michael T ^a   Mukerjee, Neeta ^b   Bierer, Barbara E ^b   Freed, Brian M ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

Catechol; Cigarette smoking; Cytokine; Hydroquinone; IFN ; IL 1 ; IL 2; Immunosuppression; Nicotine; TNF

Indexed keywords

CATECHOL; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 2; NICOTINE; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CIGARETTE SMOKING; ENZYME LINKED IMMUNOSORBENT ASSAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNE SYSTEM; LUNG; MONONUCLEAR CELL; PRIORITY JOURNAL;

EID: 0033836240     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1067/mai.2000.107751     Document Type: Article

References (46)

1. Lymphocyte studies in asymptomatic cigarette smokers. A comparison between lung and peripheral blood
2. Trends in smoking-related diseases. Why smoking cessation is still the best medicine
3. + T-lymphocyte counts: Preliminary results from the San Francisco Men's Health Study
4. The epidemiology of HIV-1 infection of the lung in AIDS patients
5. The effect of cigarette smoking on the development of AIDS in HIV-1-seropositive individuals
6. Enhanced production of human immunodeficiency virus type 1 by in vitro-infected alveolar macrophages from otherwise healthy cigarette smokers
7. The association between cigarette smoking and selected HIV-related medical conditions
8. Cigarette smoking decreases interleukin 1 release by human alveolar macrophages
9. Interleukin 1 production by alveolar macrophages is decreased in smokers
10. Cigarette smoking decreases bioactive interleukin-6 secretion by alveolar macrophages
11. Release of tumor necrosis factor-α from human alveolar macrophages is decreased in smokers
12. Altered cytokine regulation in the lungs of cigarette smokers
13. The chemical composition of tobacco and tobacco smoke
14. Nicotine inhibits the production of inflammatory mediators in U937 cells through modulation of nuclear factor-κB activation
15. The effect of nicotine on murine CD4 T cell responses
16. Nicotine inhibits the in vitro production of interleukin 2 and tumour necrosis factor-α by human mononuclear cells
17. Nicotine does not modulate IL-4 and interferon-γ release from peripheral blood mononuclear cells and T cell clones activated by phorbol myristate acetate and calcium ionophore
18. Inhibition of interferon-γ production by benzene and benzene metabolites
19. Effect of the benzene metabolite, hydroquinone, on interleukin-1 secretion by human monocytes in vitro
20. p-Benzoquinone, a reactive metabolite of benzene, prevents the processing of pre-interleukins-1α and -1β to active cytokines by inhibition of the processing enzymes, calpain, and interleukin-1β converting enzyme
21. + T lymphocytes
22. The cigarette tar component p-benzoquinone blocks T-lymphocyte activation by inhibiting interleukin-2 production, but not CD25, ICAM-1, or LFA-1 expression
23. Detection and identification of sulfhydryl conjugates of rho-benzoquinone in microsomal incubations of benzene and phenol
24. Interleukin-2: Inception, impact, and implications
25. Interferon-γ producer cells, activation stimuli, and molecular genetic regulation
26. Biologic basis for interleukin-1 in disease
27. Tumor necrosis factor-α and toxicology
28. Synergistic effects of co-expression of the TH1 cytokines IL-2 and IFN-γ on generation of murine tumor-reactive cytotoxic cells
29. The IL-2 receptor β chain (p70): Role in mediating signals for LAK, NK, and proliferative activities
30. Synergistic proliferation and activation of natural killer cells by interleukin 12 and interleukin 18
31. Local secretion of IFN-γ induces an antitumor response: Comparison between T cells plus IL-2 and IFN-γ transfected tumor cells
32. Autologous high-killing cytotoxic T lymphocytes against human lung cancer are induced using interleukin (IL)-1β, IL-2, IL-4, and IL-6: Possible involvement of dendritic cells
33. Effects of tumour necrosis factor-α (TNF-α), IL-1β and monocytes on lymphokine-activated killer (LAK) induction from natural killer (NK) cells and T lymphocytes
34. Local expression of antiinflammatory cytokines in cancer
35. Gradual loss of T-helper I populations in spleen of mice during progressive tumor growth
36. A pathogenic role of Th2 cells and their cytokine products on the pulmonary metastasis of murine B 16 melanoma
37. Cytokine levels (IL-6 and IFN-γ), acute phase response and nutritional status as prognostic factors in lung cancer
38. Regression of established pulmonary metastases and subcutaneous tumor mediated by the systemic administration of high-dose recombinant interleukin 2
39. A randomized phase II trial of continuous infusion interleukin-2 or bolus injection interleukin-2 plus lymphokine-activated killer cells for advanced renal cell carcinoma
40. Systemic administration of interleukin 2 enhances the therapeutic efficacy of dendritic cell-based tumor vaccines
41. A study of tobacco carcinogenesis. XX. Role of catechol as a major cocarcinogen in the weakly acidic fraction of smoke condensate
42. Tumor promoters and cocarcinogens in tobacco carcinogenesis
43. Inhibition of human T lymphoblast proliferation by hydroquinone
44. Differential inhibition of DNA synthesis in human T cells by the cigarette tar components hydroquinone and catechol
45. Cocarcinogenic and tumor-promoting agents in tobacco carcinogenesis
46. Tobacco smoke tumor promoters, catechol and hydroquinone, induce oxidative regulation of protein kinase C and influence invasion and metastasis of lung carcinoma cells