Acute effects of cigarette smoke on inflammation and oxidative stress: A review

Thorax

Volumn 59, Issue 8, 2004, Pages 713-721

  Van Der Vaart, H ^a   Postma, D S ^a   Timens, W ^a   Ten Hacken, N H T ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON MONOXIDE; CIGARETTE SMOKE; CYTOKINE; SCLEROPROTEIN;

CIGARETTE SMOKING; DISEASE MODEL; ENVIRONMENTAL EXPOSURE; EOSINOPHIL; HUMAN; INFLAMMATION; INFLAMMATORY CELL; LIPID DEGRADATION; LIPID PEROXIDATION; LITERATURE; LUNG FUNCTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; SMOKING; TISSUE INJURY;

ACUTE DISEASE; BRONCHITIS; BRONCHOALVEOLAR LAVAGE FLUID; HUMANS; MODELS, BIOLOGICAL; NEUTROPHILS; OXIDATIVE STRESS; SMOKE; SMOKING;

EID: 4043062803     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thx.2003.012468     Document Type: Review

References (126)

1. Murray CJ, Lopez AD. Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study. Lancet 1997;349:1498-504.
2. Kuschner WG, D'Alessandro A, Wong H, et al. Dose-dependent cigarette smoking-related inflammatory responses in healthy adults. Eur Respir J 1996;9:1989-94.
3. Hunninghake GW, Crystal RG. Cigarette smoking and lung destruction. Accumulation of neutrophils in the lungs of cigarette smokers. Am Rev Respir Dis 1983;128:833-8.
4. van Eeden SF, Hogg JC. The response of human bone marrow to chronic cigarette smoking. Eur Respir J 2000;15:915-21.
5. Morrison D, Rahman I, Lannan S, et al. Epithelial permeability, inflammation, and oxidant stress in the air spaces of smokers. Am J Respir Crit Care Med 1999;159:473-9.
6. Janoff A, Raju L, Dearing R. Levels of elastase activity in bronchoalveolar lavage fluids of healthy smokers and nonsmokers. Am Rev Respir Dis 1983;127:540-4.
7. Hockertz S, Emmendorffer A, Scherer G, et al. Acute effects of smoking and high experimental exposure to environmental tobacco smoke (ETS) on the immune system. Cell Biol Toxicol 1994;10:177-90.
8. Winkel P, Statland BE. The acute effect of cigarette smoking on the concentrations of blood leukocyte types in healthy young women. Am J Clin Pathol 1981;75:781-5.
9. Abboud RT, Fera T, Johal S, et al. Effect of smoking on plasma neutrophil elastase levels. J Lab Clin Med 1986;108:294-300.
10. Walter S, Nancy NR. Basopenia following cigarette smoking. Indian J Med Res 1980;72:422-5.
11. Walter S, Walter A. Basophil degranulation induced by cigarette smoking in man. Thorax 1982;37:756-9.
12. MacNee W, Wiggs B, Belzberg AS, et al. The effect of cigarette smoking on neutrophil kinetics in human lungs. N Engl J Med 1989;321:924-8.
13. Skwarski KM, Gorecka D, Sliwinski P, et al. The effects of cigarette smoking on pulmonary hemodynamics. Chest 1993;103:1166-72.
14. Drost EM, Selby C, Bridgeman MME, et al. Decreased leukocyte deformability after acute cigarette smoking in humans. Am Rev Respir Dis 1993;148:1277-83.
15. Patiar S, Slade D, Kirkpatrick U, et al. Smoking causes a dose-dependent increase in granulocyte-bound L- selectin. Thromb Res 2002;106:1-6.
16. Morrison D, Skwarski K, Millar AM, et al. A comparison of three methods of measuring 99mTc-DTPA lung clearance and their repeatability. Eur Respir J 1998;11:1141-6.
17. Gil E, Chen B, Kleerup E, et al. Acute and chronic effects of marijuana smoking on pulmonary alveolar permeability. Life Sci 1995;56:2193-9.
18. Ward C. Bronchoalveolar lavage fluid urea as a marker of pulmonary permeability in healthy smokers. Eur Respir J 2000;15:285.
19. Kaplan JD, Calandrino FS, Schuster DP. Effect of smoking on pulmonary vascular permeability. A positron emission tomography study. Am Rev Respir Dis 1992;145:712-5.
20. Montuschi P, Collins JV, Ciabattoni G, et al. Exhaled 8-isoprostane as an in vivo biomarker of lung oxidative stress in patients with COPD and healthy smokers. Am J Respir Crit Care Med 2000;162:1175-7.
21. Guatura SB, Martinez JA, Santos Bueno PC, et al. Increased exhalation of hydrogen peroxide in healthy subjects following cigarette consumption. Sao Paulo Med J 2000;118:93-8.
22. Chambers DC, Tunnicliffe WS, Ayres JG. Acute inhalation of cigarette smoke increases lower respiratory tract nitric oxide concentrations. Thorax 1998;53:677-9.
23. Kharitonov SA, Robbins RA, Yates D, et al. Acute and chronic effects of cigarette smoking on exhaled nitric oxide. Am J Respir Crit Care Med 1995;152:609-12.
24. Balint B, Donnelly LE, Hanazawa T, et al. Increased nitric oxide metabolites in exhaled breath condensate after exposure to tobacco smoke. Thorax 2001;56:456-61.
25. Tsuchiya M, Asada A, Kasahara E, et al. Smoking a single cigarette rapidly reduces combined concentrations of nitrate and nitrite and concentrations of antioxidants in plasma. Circulation 2002;105:1155-7.
26. Rahman I, Morrison D, Donaldson K, et al. Systemic oxidative stress in asthma, COPD, and smokers. Am J Respir Crit Care Med 1996;154:1055-60.
27. Morrow JD, Frei B, Longmire AW, et al. Increase in circulating products of lipid peroxidation (F2- isoprostanes) in smokers. Smoking as a cause of oxidative damage. N Engl J Med 1995;332:1198-203.
28. Tardif J, Borgeat P, Laviolette M. Inhibition of human alveolar macrophage production of leukotriene B4 by acute in vitro and in vivo exposure to tobacco smoke. Am J Respir Cell Mol Biol 1990;2:155-61.
29. Kobayashi J, Kihira Y, Kitamura S. Effects of cigarette smoking on blood levels of leukotrienes and plasma levels of complements C3a and C5a in healthy volunteers. Arch Environ Health 1988;43:371-4.
30. Fauler J, Frolich JC. Cigarette smoking stimulates cysteinyl leukotriene production in man. Eur J Clin Invest 1997;27:43-7.
31. Vitalis TZ, Kern I, Croome A, et al. The effect of latent adenovirus 5 infection on cigarette smoke-induced lung inflammation. Eur Respir J 1998;11:664-9.
32. Hulbert WC, Walker DC, Jackson A, et al. Airway permeability to horseradish peroxidase in guinea pigs: the repair phase after injury by cigarette smoke. Am Rev Respir Dis 1981;123:320-6.
33. Kilburn KH, McKenzie W. Leukocyte recruitment to airways by cigarette smoke and particle phase in contrast to cytotoxicity of vapor. Science 1975;189:634-7.
34. Dhami R, Gilks B, Xie C, et al. Acute cigarette smoke-induced connective tissue breakdown is mediated by neutrophils and prevented by alpha1-antitrypsin. Am J Respir Cell Mol Biol 2000;22:244-52.
35. Ishizaki T, Kishi Y, Sasaki F, et al. Effect of probucol, an oral hypocholesterolaemic agent, on acute tobacco smoke inhalation in rats. Clin Sci (Lond) 1996;90:517-23.
36. Cavarra E, Lucattelli M, Gambelli F, et al. Human SLPI inactivation after cigarette smoke exposure in a new in vivo model of pulmonary oxidative stress. Am J Physiol Lung Cell Mol Physiol 2001;281:L412-7.
37. Daffonchio L, Hernandez A, Omini C. Sensory neuropeptides are involved in cigarette smoke induced airway hyperreactivity in guinea-pig. Agents Actions Suppl 1990;31:215-22.
38. Ortega E, Hueso F, Collazos ME, et al. Phagocytosis of latex beads by alveolar macrophages from mice exposed to cigarette smoke. Comp Immunol Microbiol Infect Dis 1992;15:137-42.
39. Mordelet-Dambrine M, Leguern-Stanislas G, Chinet TC, et al. Effects of tobacco smoke on respiratory epithelial clearance of DTPA and on lung histology in rats. Eur Respir J 1991;4:839-44.
40. Li XY, Rahman I, Donaldson K, et al. Mechanisms of cigarette smoke induced increased airspace permeability. Thorax 1996;51:465-71.
41. Pessina GP, Paulesu L, Corradeschi F, et al. Production of tumor necrosis factor alpha by rat alveolar macrophages collected after acute cigarette smoking. Arch Immunol Ther Exp (Warsz) 1993;41:343-8.
42. Churg A, Dai J, Tai H, et al. Tumor necrosis factor-alpha is central to acute cigarette smoke-induced inflammation and connective tissue breakdown. Am J Respir Crit Care Med 2002;166:849-54.
43. Churg A, Zay K, Shay S, et al. Acute cigarette smoke-induced connective tissue breakdown requires both neutrophils and macrophage metalloelastase in mice. Am J Respir Cell Mol Biol 2002;27:368-74.
44. Yamaya M, Zayasu K, Sekizawa K, et al. Acute effect of cigarette smoke on cytoplasmic motility of alveolar macrophages in dogs. J Appl Physiol 1989;66:1172-8.
45. Ortega E, Barriga C, Rodriguez AB. Decline in the phagocytic function of alveolar macrophages from mice exposed to cigarette smoke. Comp Immunol Microbiol Infect Dis 1994;17:77-84.
46. Holt PG, Keast D. Acute effects of cigarette smoke on murine macrophages. Arch Environ Health 1973;26:300-4.
47. Wright J, Harrison N. Cardiopulmonary effects of a brief exposure to cigarette smoke in the guinea pig. Respiration 1990;57:70-6.
48. Kew RR, Ghebrehiwet B, Janoff A. The role of complement in cigarette smoke-induced chemotactic activity of lung fluids. Am Rev Respir Dis 1986;133:478-81.
49. Abrams WR, Kucich U, Kimbel P, et al. Acute cigarette smoke exposure in dogs: the inflammatory response. Exp Lung Res 1988;14:459-75.
50. Wright JL, Farmer SG, Churg A. Synthetic serine elastase inhibitor reduces cigarette smoke-induced emphysema in guinea pigs. Am J Respir Crit Care Med 2002;166:954-60.
51. Nishikawa M, Ikeda H, Fukuda T, et al. Acute exposure to cigarette smoke induces airway hyperresponsiveness without airway inflammation in guinea pigs. Dose-response characteristics. Am Rev Respir Dis 1990;142:177-83.
52. Simani AS, Inoue S, Hogg JC. Penetration of the respiratory epithelium of guinea pigs following exposure to cigarette smoke. Lab Invest 1974;31:75-81.
53. Witten ML, Quan SF, Sobanya RE, et al. Acute cigarette smoke exposure alters lung eicosanoid and inflammatory cell concentrations in rabbits. Exp Lung Res 1988;14:727-42.
54. Burns AR, Hosford SP, Dunn LA, et al. Respiratory epithelial permeability after cigarette smoke exposure in guinea pigs. J Appl Physiol 1989;66:2109-16.
55. Boucher RC, Johnson J, Inoue S, et al. The effect of cigarette smoke on the permeability of guinea pig airways. Lab Invest 1980;43:94-100.
56. Witten ML, Lemen RJ, Quan SF, et al. Acute cigarette smoke exposure increases alveolar permeability in rabbits. Am Rev Respir Dis 1985;132:321-5.
57. Reznik-Schuller HM. Acute effects of cigarette smoke inhalation on the Syrian hamster lungs. J Environ Pathol Toxicol 1980;4:285-91.
58. Bilimoria MH, Ecobichon DJ. Protective antioxidant mechanisms in rat and guinea pig tissues challenged by acute exposure to cigarette smoke. Toxicology 1992;72:131-44.
59. Cotgreave IA, Johansson U, Moldeus P, et al. The effect of acute cigarette smoke inhalation on pulmonary and systemic cysteine and glutathione redox states in the rat. Toxicology 1987;45:203-12.
60. Aoshiba K, Koinuma M, Yokohori N, et al. Immunohistochemical evaluation of oxidative stress in murine lungs after cigarette smoke exposure. Inhol Toxicol 2003;15:1029-38.
61. Wright JL, Dai J, Zay K, et al. Effects of cigarette smoke on nitric oxide synthase expression in the rat lung. Lab Invest 1999;79:975-83.
62. Uotila P. Effect of cigarette smoke on glucuronide conjugation in hamster isolated lungs. Res Commun Chem Pathol Pharmacol 1982;38:173-6.
63. Churg A, Wang RD, Tai H, et al. Macrophage metalloelastase mediates acute cigarette smoke-induced inflammation via tumor necrosis factor-alpha release. Am J Respir Crit Care Med 2003;167:1083-9.
64. Pessina GP, Paulesu L, Corradeschi F, et al. Pulmonary catabalism of interleukin 6 evaluated by lung perfusion of normal and smoker rats. J Pharm Pharmacol 1996;48:1063-7.
65. Janoff A, Carp H, Lee DK, et al. Cigarette smoke inhalation decreases alpha 1-antitrypsin activity in rat lung. Science 1979;206:1313-4.
66. Bosken CH, Doerschuk CM, English D, et al. Neutrophil kinetics during active cigarette smoking in rabbits. J Appl Physiol 1991;71:630-7.
67. Sato E, Koyama S, Takamizawa A, et al. Smoke extract stimulates lung fibroblasts to release neutrophil and monocyte chemotactic activities. Am J Physiol 1999;277:L1149-57.
68. Koyama S, Rennard SI, Leikauf GD, et al. Bronchial epithelial cells release monocyte chemotactic activity in response to smoke and endotoxin. J Immunol 1991;147:972-9.
69. Shoji S, Ertl RF, Koyama S, et al. Cigarette smoke stimulates release of neutrophil chemotactic activity from cultured bavine bronchial epithelial cells. Clin Sci (Lond) 1995;88:337-44.
70. Bridges RB, Kraal JH, Huang LJ, et al. Effects of tobacco smoke on chemotaxis and glucose metabolism of polymorphonuclear leukocytes. Infect Immun 1977;15:115-23.
71. Selby C, Drost E, Brown D, et al. Inhibition of neutrophil adherence and movement by acute cigarette smoke exposure. Exp Lung Res 1992;18:813-27.
72. Robbins RA, Koyama S, Spurzem JR, et al. Modulation of neutrophil and mononuclear cell adherence to bronchial epithelial cells. Am J Respir Cell Mol Biol 1992;7:19-29.
73. Kalra VK, Ying Y, Deemer K, et al. Mechanism of cigarette smoke condensate induced adhesion of human monocytes to cultured endothelial cells. J Cell Physiol 1994;160:154-62.
74. Floreani AA, Wyatt TA, Stoner J, et al. Smoke and C5a induce airway epithelial intercellular adhesion molecule-1 and cell adhesion. Am J Respir Cell Mol Biol 2003;29:472-82.
75. Shen Y, Rattan V, Sultana C, et al. Cigarette smoke condensate-induced adhesion molecule expression and transendothelial migration of monocytes. Am J Physiol 1996;270:H1624-33.
76. Ryder MI, Fujitaki R, Lebus S, et al. Alterations of neutrophil L-selection and CD18 expression by tobacco smoke: implications for periodontal diseases. J Periodontal Res 1998;33:359-68.
77. Thomas WR, Holt PG, Keast D. Cigarette smoke and phagocyte function: effect of chronic exposure in vivo and acute exposure in vitro. Infect Immun 1978;20:468-75.
78. Green GM, Carolin D. The depressant effect of cigarette smoke on the in vitro antibacterial activity of alveolar macrophages. N Engl J Med 1967;276:421-7.
79. Voisin C, Aerts C, Fournier E, et al. Acute effects of tobacco smoke on alveolar macrophages cultured in gas phase. Eur J Respir Dis Suppl 1985;139:76-81.
80. Zappacosta B, Persichilli S, Minucci A, et al. Effect of aqueous cigarette smoke extract on the chemiluminescence kinetics of polymorphonuclear leukocytes and on their glycolytic and phagocytic activity. Luminescence 2001;16:315-9.
81. Holt PG, Keast D. The effect of tobacco smoke on protein synthesis in macrophages. Proc Soc Exp Biol Med 1973;142:1243-7.
82. Yeager H Jr. Alveolar cells: depression effect of cigarette smoke on protein synthesis. Proc Soc Exp Biol Med 1969;131:247-50.
83. Nakamura Y, Romberger DJ, Tate L, et al. Cigarette smoke inhibits lung fibroblast proliferation and chemotaxis. Am J Respir Crit Care Med 1995;151:1497-503.
84. Carnevali S, Nakamura Y, Mio T, et al. Cigarette smoke extract inhibits fibroblast-mediated collagen gel contraction. Am J Physiol 1998;274:L591-8.
85. Kim HJ, Liu X, Wang H, et al. Glutathione prevents inhibition of fibroblastmediated collagen gel contraction by cigarette smoke. Am J Physiol Lung Cell Mol Physiol 2002;283:L409-17.
86. Carnevali S, Petruzzelli S, Longoni B, et al. Cigarette smoke extract induces oxidative stress and apoptosis in human lung fibroblasts. Am J Physiol Lung Cell Mol Physiol 2003;284:L955-63.
87. Hoshino Y, Mio T, Nagai S, et al. Cytotoxic effects of cigarette smoke extract on an alveolar type II cell-derived cell line. Am J Physiol Lung Cell Mol Physiol 2001;281:L509-16.
88. Tuder RM, Wood K, Taraseviciene L, et al. Cigarette smoke extract decreases the expression of vascular endothelial growth factor by cultured cells and triggers apoptosis of pulmonary endothelial cells. Chest 2000;117:241-2S.
89. Ishii T, Matsuse T, Igarashi H, et al. Tobacco smoke reduces viability in human lung fibroblasts: protective effect of glutathione S-transferase P1. Am J Physiol Lung Cell Mol Physiol 2001;280:L1189-95.
90. Aoshiba K, Tamaoki J, Nagai A. Acute cigarette smoke exposure induces apoptosis of alveolar macrophages. Am J Physiol Lung Cell Mol Physiol 2001;281:L1392-401.
91. Vayssier-Taussat M, Camilli T, Aron Y, et al. Effects of tobacco smoke and benzo[a]pyrene on human endothelial cell and monocyte stress responses. Am J Physiol Heart Circ Physiol 2001;280:H1293-300.
92. Vayssier M, Banzet N, Francois D, et al. Tobacco smoke induces bath apoptosis and necrosis in mammalian cells: differential effects of HSP70. Am J Physiol 1998;275:L771-9.
93. Wickenden JA, Clarke MC, Rossi AG, et al. Cigarette smoke prevents apoptosis through inhibition of caspase activation and induces necrosis. Am J Respir Cell Mol Biol 2003;29:562-70.
94. Rusznak C, Mills PR, Devalia JL, et al. Effect of cigarette smoke on the permeability and IL-1beta and sICAM-1 release from cultured human bronchial epithelial cells of never- smokers, smokers, and potients with chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 2000;23:530-6.
95. Li XY, Donaldson K, Rahman I, et al. An investigation of the role of glutathione in increased epithelial permeability induced by cigarette smoke in vivo and in vitro. Am J Respir Crit Care Med 1994;149:1518-25.
96. Wirtz HR, Schmidt M. Acute influence of cigarette smoke on secretion of pulmonary surfactant in rat alveolar type II cells in culture. Eur Respir J 1996;9:24-32.
97. Pinot F, Bachelet M, Francois D, et al. Modified natural porcine surfactant modulates tobacco smoke-induced stress response in human monocytes. Life Sci 1999;64:125-34.
98. Takeyama K, Jung B, Shim JJ, et al. Activation of epidermal growth factor receptors is responsible for mucin synthesis induced by cigarette smoke. Am J Physiol Lung Cell Mol Physiol 2001;280:L165-72.
99. Falk HL, Tremer HM, Kotin P. Effect of cigarette smoke and its constituents on ciliated mucus-secreting epithelium. J Natl Cancer Inst 1959;23:999-1012.
100. Noronha-Dutra AA, Epperlein MM, Woolf N. Effect of cigarette smoking on cultured human endothelial cells. Cardiovasc Res 1993;27:774-8.
101. Bridgeman MME, Morsden M, Drost E, et al. The effect of cigarette smoke on lung cells. Am Rev Respir Dis 1991;143:A737.
102. Rahman I, Smith CA, Lawson MF, et al. Induction of gammaglutamylcysteine synthetase by cigarette smoke is associated with AP-1 in human alveolar epithelial cells. FEBS Lett 1996;396:21-5.
103. Hobson J, Wright J, Churg A. Histochemical evidence for generation of active oxygen species on the apical surface of cigarette-smoke-exposed tracheal explants. Am J Pathol 1991;139:573-80.
104. Hoyt JC, Robbins RA, Habib M, et al. Cigarette smoke decreases inducible nitric oxide synthase in lung epithelial cells. Exp Lung Res 2003;29:17-28.
105. Rusznak C, Sapsford RJ, Devalia JL, et al. Interaction of cigarette smoke and house dust mite allergens on inflammatory mediator release from primary cultures of human bronchial epithelial cells. Clin Exp Allergy 2001;31:226-38.
106. Wang HY, Ye YN, Zhu M, et al. Increased interleukin-8 expression by cigarette smoke extract in endothelial cells. Environ Toxicol Pharmacol 2000;9:19-23.
107. Richter A, O'Donnell RA, Powell RM, et al. Autocrine ligands for the epidermal growth factor receptor mediate interleukin-8 release from bronchial epithelial cells in response to cigarette smoke. Am J Respir Cell Mol Biol 2002;27:85-90.
108. Mio T, Romberger DJ, Thompson AB, et al. Cigarette smoke induces interleukin-8 release from human bronchial epithelial cells. Am J Respir Crit Care Med 1997;155:1770-6.
109. Witherden IR, Goldstraw P, Pastorino U, et al. Interleukin-8 release by primary human alveolar type II cells in vitro: effect of neutrophil elastase and cigarette smoke. Respir Med 1997;91:A27.
110. Ryder MI, Saghizadeh M, Ding Y, et al. Effects of tobacco smoke on the secretion of interleukin-1 beta, tumor necrosis factor-alpha, and transforming growth factor-beta from peripheral blood mononuclear cells. Oral Microbiol Immunol 2002;17:331-6.
111. Ouyang Y, Virasch N, Hao P, et al. Suppression of human IL-1 beta, IL-2, IFN-gamma, and TNF-alpha production by cigarette smoke extracts. J Allergy Clin Immunol 2000;106:280-7.
112. Higashimoto Y, Shimada Y, Fukuchi Y, et al. Inhibition of mouse alveolar macrophage production of tumor necrosis factor alpha by acute in vivo and in vitro exposure to tobacco smoke. Respiration 1992;59:77-80.
113. Zhang X, Wang L, Zhang H, et al. The effects of cigarette smoke extract on the endothelial production of soluble intercellular adhesion molecule-1 are mediated through macrophages, possibly by inducing TNF-alpha release. Methods Find Exp Clin Pharmacol 2002;24:261-5.
114. Hellermann GR, Nagy SB, Kong X, et al. Mechanism of cigarette smoke condensate-induced acute inflammatory response in human bronchial epithelial cells. Respir Res 2002;3:22.
115. Dubar V, Gosset P, Aerts C, et al. In vitro acute effects of tobacco smoke on tumor necrosis factor alpha and interleukin-6 production by alveolar macrophages. Exp Lung Res 1993;19:345-59.
116. Brown GM, Drost E, Donaldson K, et al. Reduction of the proteolytic activity of neutrophils by exposure to cigarette smoke in vitro. Exp Lung Res 1991;17:923-37.
117. Johnson JD, Houchens DP, Kluwe WM, et al. Effects of mainstream and environmental tobacco smoke on the immune system in animals and humans: a review. Crit Rev Toxicol 1990;20:369-95.
118. Stedman RL. The chemical composition of tobacco and tobacco smoke. Chem Rev 1968;68:153-207.
119. Guerin MR, Higgins CE, Griest WH. The analysis of the particulate and vapour phases of tobacco smoke. IARC Sci Publ 1987:115-39.
120. Morse D, Choi AM. Heme oxygenase-1: the "emerging molecule" has arrived. Am J Respir Cell Mol Biol 2002;27:8-16.
121. Papi A, Romagnoli M, Baraldo S, et al. Partial reversibility of airflow limitation and increased exhaled NO and sputum eosinophilia in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2000;162:1773-7.
122. Saetta M, Di Stefano A, Maestrelli P, et al. Airway eosinophilia in chronic bronchitis during exacerbations. Am J Respir Crit Care Med 1994;150:1646-52.
123. Chapmon JT, Otterbein LE, Elias JA, et al. Carbon monoxide attenuates aeroallergen-induced inflammation in mice. Am J Physiol Lung Cell Mol Physiol 2001;281:L209-16.
124. Melgert BN, Postma DS, Geerlings M, et al. Short-term smoke exposure attenuates ovalbumin-induced bronchoconstriction, hyperresponsiveness, and airway inflammation in mice. Am J Respir Crit Care Med 2003;167:A64.
125. Erjefalt JS, Persson CG. Airway epithelial repoir: breathtakingly quick and multipotentially pathogenic. Thorax 1997;52:1010-2.
126. Yamada N, Yamaya M, Okinaga S, et al. Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema. Am J Hum Genet 2000;66:187-95.