Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells

Journal of Clinical Investigation

Volumn 111, Issue 1, 2003, Pages 81-90

  West, Kip A ^a   Brognard, John ^a   Clark, Amy S ^a   Linnoila, Ilona R ^a   Yang, Xiaowei ^a   Swain, Sandra M ^a   Harris, Curtis ^a   Belinsky, Steven ^b   Dennis, Phillip A ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANOL; ETOPOSIDE; GROWTH FACTOR; HYDROGEN PEROXIDE; NICOTINE; NICOTINIC RECEPTOR; PROTEIN SERINE THREONINE KINASE;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL GROWTH; CONTACT INHIBITION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LUNG CANCER; MOUSE; NONHUMAN; PHENOTYPE; PHOSPHORYLATION; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM; SMOKING; ULTRAVIOLET RADIATION; UNITED STATES;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; APOPTOSIS; BRONCHI; CARCINOGENS; CARRIER PROTEINS; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; DNA-BINDING PROTEINS; ENZYME ACTIVATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIAL CELLS; FORKHEAD TRANSCRIPTION FACTORS; GLYCOGEN SYNTHASE KINASE 3; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; NICOTINE; NITROSAMINES; PHENOTYPE; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; TIME FACTORS; TOBACCO; TRANSCRIPTION FACTORS; ULTRAVIOLET RAYS;

EID: 0037251810     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200316147     Document Type: Article

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