On the origin of G → T transversions in lung cancer

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 526, Issue 1-2, 2003, Pages 39-43

  Pfeifer, Gerd P ^a   Hainaut, Pierre ^b  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

Author keywords

Lung cancer; Mutations; Polycyclic aromatic hydrocarbons; TP53

Indexed keywords

POLYCYCLIC AROMATIC HYDROCARBON; DNA; GUANINE; PROTEIN P53; THYMIDINE;

ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; DATA BASE; DNA DAMAGE; DNA REPAIR; DNA SEQUENCE; DNA STRAND; GENE EXPRESSION; HUMAN; LUNG ALVEOLUS EPITHELIUM; LUNG CANCER; LUNG TUMOR; MUTAGENESIS; MUTAGENIC ACTIVITY; MUTATION RATE; OXIDATIVE STRESS; PRIORITY JOURNAL; REPORTER GENE; SMOKING; STRESS; CHEMISTRY; DRUG EFFECT; GENE FREQUENCY; GENETIC DATABASE; GENETICS; REVIEW;

DATABASES, GENETIC; DNA DAMAGE; DNA REPAIR; DNA, NEOPLASM; GENE FREQUENCY; GUANINE; HUMANS; LUNG NEOPLASMS; MUTAGENESIS; POLYCYCLIC HYDROCARBONS, AROMATIC; SMOKING; THYMIDINE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0037448026     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(03)00013-7     Document Type: Article

References (28)

1. Hainaut P., Pfeifer G.P. Patterns of TP53 G to T transversions in lung cancers reflect the primary mutagenic signature of DNA-damage by tobacco smoke. Carcinogenesis. 22:2001;367-374.
2. Hecht S.S. Tobacco smoke carcinogens and lung cancer. J. Natl. Cancer Inst. 91:1999;1194-1210.
3. Pfeifer G.P., Denissenko M.F., Olivier M., Tretyakova N., Hecht S.S., Hainaut P. Tobacco smoke carcinogens, DNA damage and TP53 mutations in smoking-associated cancers. Oncogene. 21:2002;7435-7451.
4. Denissenko M.F., Pao A., Pfeifer G.P., Tang M.-s. Slow repair of bulky DNA adducts along the non-transcribed strand of the human TP53 gene may explain the strand bias of transversion mutations in cancers. Oncogene. 16:1998;1241-1247.
5. Denissenko M.F., Pao A., Tang M.-s., Pfeifer G.P. Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in TP53. Science. 274:1996;430-432.
6. Smith L.E., Denissenko M.F., Bennett W.P., Li H., Amin S., Tang M.-s., Pfeifer G.P. Targeting of lung cancer mutational hotspots by polycyclic aromatic hydrocarbons. J. Natl. Cancer Inst. 92:2000;803-811.
7. Rodin S.N., Rodin A.S. Human lung cancer and TP53: The interplay between mutagenesis and selection. Proc. Natl. Acad. Sci. U.S.A. 97:2000;12244-12249.
8. Rodin S., Rodin A. On the origin of TP53 G:C - > T:A transversions in lung cancers. Mutat. Res. 508:2002;1-19.
9. Chen R.H., Maher V.M., Brouwer J., van de Putte P., McCormick J.J. Preferential repair and strand-specific repair of benzo[a]pyrene diol epoxide adducts in the HPRT gene of diploid human fibroblasts. Proc. Natl. Acad. Sci. U.S.A. 89:1992;5413-5417.
10. Hanawalt P.C. Role of transcription-coupled DNA repair in susceptibility to environmental carcinogenesis. Environ. Health Perspect. 104(Suppl 3):1996;547-551.
11. van Hoffen A., Venema J., Meschini R., van Zeeland A.A., Mullenders L.H. Transcription-coupled repair removes both cyclobutane pyrimidine dimers and 6-4 photoproducts with equal efficiency and in a sequential way from transcribed DNA in xeroderma pigmentosum group C fibroblasts. EMBO J. 14:1995;360-367.
12. Osann K.E., Lowery J.T., Schell M.J. Small cell lung cancer in women: risk associated with smoking, prior respiratory disease, and occupation. Lung Cancer. 28:2000;1-10.
13. Wistuba, II, D. Bryant, C. Behrens, S. Milchgrub, A.K. Virmani, R. Ashfaq, J.D. Minna, A.F. Gazdar, Comparison of features of human lung cancer cell lines and their corresponding tumors, Clin. Cancer Res. 5 (1999) 991-1000.
14. Montesano R., Hollstein M., Hainaut P. Genetic alterations in esophageal cancer and their relevance to etiology and pathogenesis: a review. Int. J. Cancer. 69:1996;225-235.
15. Le Page F., Klungland A., Barnes D.E., Sarasin A., Boiteux S. Transcription coupled repair of 8-oxoguanine in murine cells: the ogg1 protein is required for repair in non-transcribed sequences but not in transcribed sequences. Proc. Natl. Acad. Sci. U.S.A. 97:2000;8397-8402.
16. Anson R.M., Croteau D.L., Stierum R.H., Filburn C., Parsell R., Bohr V.A. Homogenous repair of singlet oxygen-induced DNA damage in differentially transcribed regions and strands of human mitochondrial DNA. Nucl. Acids Res. 26:1998;662-668.
17. Thorslund T., Suneson M., Bohr V.A., Stevnsner T. Repair of 8-oxoG is slower in endogenous nuclear genes than in mitochondrial DNA and is without strand bias. DNA Repair. 1:2002;261-273.
18. Chevillard S., Radicella J.P., Levalois C., Lebeau J., Poupon M.F., Oudard S., Dutrillaux B., Boiteux S. Mutations in OGG1, a gene involved in the repair of oxidative DNA damage, are found in human lung and kidney tumours. Oncogene. 16:1998;3083-3086.
19. Shinmura K., Yamaguchi S., Saitoh T., Kohno T., Yokota J. Somatic mutations and single nucleotide polymorphisms of base excision repair genes involved in the repair of 8-hydroxyguanine in damaged DNA. Cancer Lett. 166:2001;65-69.
20. Jackson A.L., Loeb L.A. The contribution of endogenous sources of DNA damage to the multiple mutations in cancer. Mutat. Res. 477:2001;7-21.
21. Warren W., Biggs P.J., El-Baz M., Ghoneim M.A., Stratton M.R., Venitt S. Mutations in the TP53 gene in schistosomal bladder cancer: a study of 92 tumours from Egyptian patients and a comparison between mutational spectra from schistosomal and non-schistosomal urothelial tumours. Carcinogenesis. 16:1995;1181-1189.
22. Hussain S.P., Amstad P., Raja K., Ambs S., Nagashima M., Bennett W.P., Shields P.G., Ham A.J., Swenberg J.A., Marrogi A.J., Harris C.C. Increased TP53 mutation load in noncancerous colon tissue from ulcerative colitis: a cancer-prone chronic inflammatory disease. Cancer Res. 60:2000;3333-3337.
23. Sepehr A., Taniere P., Martel-Planche G., Zia'ee A.A., Rastgar-Jazii F., Yazdanbod M., Etemad-Moghadam G., Kamangar F., Saidi F., Hainaut P. Distinct pattern of TTP53 mutations in squamous cell carcinoma of the esophagus in Iran. Oncogene. 20:2001;7368-7374.
24. Biramijamal F., Allameh A., Mirbod P., Groene H.J., Koomagi R., Hollstein M. Unusual profile and high prevalence of TP53 mutations in esophageal squamous cell carcinomas from northern Iran. Cancer Res. 61:2001;3119-3123.
25. Lee D.H., O'Connor T.R., Pfeifer G.P. Oxidative DNA damage induced by copper and hydrogen peroxide promotes CG - >TT tandem mutations at methylated CpG dinucleotides in nucleotide excision repair-deficient cells. Nucl. Acids Res. 30:2002;3566-3573.
26. Hussain S.P., Amstad P., Raja K., Sawyer M., Hofseth L., Shields P.G., Hewer A., Phillips D.H., Ryberg D., Haugen A., Harris C.C. Mutability of TP53 hotspot codons to benzo(a)pyrene diol epoxide (BPDE) and the frequency of TP53 mutations in non-tumorous human lung. Cancer Res. 61:2001;6350-6355.
27. Yoon J.H., Smith L.E., Feng Z., Tang M., Lee C.S., Pfeifer G.P. Methylated CpG dinucleotides are the preferential targets for G-to-T transversion mutations induced by benzo[a]pyrene diol epoxide in mammalian cells: similarities with the TP53 mutation spectrum in smoking-associated lung cancers. Cancer Res. 61:2001;7110-7117.
28. DeMarini D.M., Landi S., Tian D., Hanley N.M., Li X., Hu F., Roop B.C., Mass M.J., Keohavong P., Gao W., Olivier M., Hainaut P., Mumford J.L. Lung tumor KRAS and TTP53 mutations in non-smokers reflect exposure to PAH-rich coal combustion emissions. Cancer Res. 61:2001;6679-6681.