K-ras and p53 mutations are an independent unfavourable prognostic indicator in patients with non-small-cell lung cancer

British Journal of Cancer

Volumn 75, Issue 8, 1997, Pages 1125-1130

  Fukuyama, Y ^a   Mitsudomi, T ^b   Sugio, K ^a   Ishida, T ^a   Akazawa, K ^a   Sugimachi, K ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b AICHI CANCER CENTER HOSPITAL   (Japan)

Author keywords

K ras; Lung cancer; Mutation; p53

Indexed keywords

PROTEIN P53;

ADULT; AGED; ARTICLE; CANCER GENETICS; CANCER STAGING; FEMALE; GENE MUTATION; HUMAN; HUMAN TISSUE; LUNG ADENOCARCINOMA; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; MUTATION RATE; ONCOGENE K RAS; PRIORITY JOURNAL; PROGNOSIS; SQUAMOUS CELL CARCINOMA; STATISTICAL ANALYSIS; TUMOR SUPPRESSOR GENE;

EID: 0030894182     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1997.194     Document Type: Article

References (40)

1. Borresen AL, Andersen TI, Eyfjord JE, Cornelis RS, Thorlacius S, Borg A, Johansson U, Theillet C, Scherneck S, Hartman S, Cornelisse CJ, Hovig E and Devilee P (1995) TP53 mutations and breast cancer prognosis: particularly poor survival rates for cases with mutations in the zinc-binding domains. Genes Chrom Cancer 14: 71-75
2. Bos JL (1989) ras oncogenes in human cancer: a review. Cancer Res 49: 4682-4689
3. El-Deiry WS, Tokino T, Velculesco VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW and Vogelstein B (1993) Wafl, a potential mediator of p53 tumor suppression. Cell 75: 817-825
4. Eliyahu D, Raz A, Gruss P, Givol D and Oren M (1984) Participaticin of p53 cellular tumour antigen in transformation of normal embryonic cells, Nature 312: 646-649
5. Fearon ER and Vogelstein B (1990) A genetic model for colorectal tumorigenesis. Cell 61: 759-767
6. Hinds PW, Finlay CA, Quartin RS, Haker SJ, Fearon ER, Vogelstein B and Levine AJ (1990) Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the 'hot spot' mutant phenotypes. Cell Growth Different 1: 571-580
7. Hopkins A (1990) Survival analysis with covariates. In BMDP Statistical Software Manual, Vol. 2, Brown WJ, Engelman L, Hill MA and Jennrich RI (eds), pp. 769-806. University of California Press: Berkeley
8. Horio Y, Takahashi T, Kuroishi T, Hibi K, Suyama M, Niimi T, Shimokawa K, Vamakawa K, Nakamura Y, Ueda R and Takahashi T (1993) Prognostic significance of p51 mutations and 3p deletions in primary resected non-small cell lung cancer. Cancer Res 53: 1-4
9. Hunter T (1991) Cooperation between oncogenes. Cell 64: 249-270
10. Iggo R, Gatter K, Bartek J, Lane D and Harris AL (1990) Increased expression of mutant forms of p53 oncogene in primary lung cancer. Lancet 335: 675-679
11. Kalbfleisch JD and Prentice RL (1980) The proportional hazards model. In The Statistical Analysis of Failure Time Data, Kalbfleisch JD and Prentice RI, (eds), pp. 70-118. John Wiley & Sons: New York
12. Kaplan EL and Meier P (1958) Nonparametric estimation from incomplete observation. J Am Stat Assoc 53: 457-481
13. Kern JA, Slebos RJC, Top B, Rodenhuis S, Lager D, Robinson RA, Weiner D and Schwartz DA (1994) C-erbB-2 expression and codon 12 K-ras mutations both predict shortened survival for patients with pulmonary adenocarcinonias. J Clin Invest 93: 516-520
14. Kishimoto Y, Murakami Y, Shiraishi M, Hayashi K and Sekiya T (1992) Aberrations of the p53 tumor suppressor gene in human non-small cell lung carcinomas of the lung. Cancer Res 52: 4799-4804
15. Land H, Parada LF and Weinberg RA (1983) Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature 304: 596-602
16. Lee JS, Yoon A, Kalapurakal SK, RO JY, Lee JJ, Tu N, Hittleman WN and Hong WK (1995) Expression of p53 oncoprotein in non-small cell lung cancer: a favorable prognostic factor. J Clin Oncol 13: 1893-1903
17. Levine AJ, Momand J and Finlay CA (1991) The p53 tumour suppressor gene. Nature 351: 453-456
18. McLaren R, Kuzu I, Dunnill M, Harris A, Lane D and Gaiter KC (1492) The relationship of p53 immunostaining to survival in carcinoma of the lung. Br J Cancer 66: 735-738
19. Miller CW, Simon K, Aslo A, Kok K, Yokota J. Buys CHCM, Terada M and Koeffler HP (1992) p53 mutations in human lung tumors. Cancer Res 52: 1645-1698
20. Minna JD (1993) The molecular biology of lung cancer pathogenesis. Chest 103: 449s-456s
21. Mitsudomi T, Steinberg SM, Oie HK, Mulshine JL, Phelps R, Viallet J, Pass H, Minna JD and Gazdar AF (1991a) ras gene mutations in non-small cell lung cancers are associated with shortened survival irrespective of treatment intent. Cancer Res 51: 4999-5002
22. Mitsudomi T, Viallet J, Mulshine JL, Linnoila RI, Minna JD and Gazdar AF (1991b) Mutations of ras genes distinguish a subset of non-small-cell lung cancer cell lines from small-cell lung cancel cell lines. Oncogene 6: 1353-1362
23. Mitsudomi T, Steinberg SM, Nau MM, Carbone D, D'amico D, Bodner S, Oie HK, Linnoila RI, Mulshine JL, Minna JD and Gazdar AF (1992) p53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features. Oncogene 7: 171-180
24. Mitsudomi T, Oyama T, Kusano T, Osaki T, Nakanishi R and Shirakusa T (1993) Mutations of the p53 gene as a predictor of poor prognosis in patients with non-small-cell lung cancer. J Natl Cancer Inst 85: 2018-2023
25. Mitsudomi T, Oyama T, Nishida K, Ogami A, Osaki T, Nakanishi R, Sugio K, Yasumoto K and Sugimachi K (1995) Nuclear immunostaining and gene mutations in non-small cell lung cancer and their effects on patient survival. Ann Oncol 10: S9-S13
26. Nishio M, Koshikawa T, Kuroishi T, Suyama M, Uchida K, Takagi Y, Washimi O, Sugiura T, Ariyoshi Y, Takahashi T, Ueda R and Takahashi T (1996) Prognostic significance of abnormal p53 accumulation in primary, resected non-small-cell lung cancers. J Clin Oncol 14: 497-502
27. Orita M, Iwahana H, Kanazawa H, Hayashi K and Sekiya T (1989) Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms. Proc Natl Acad Sci USA 86: 2766-2770
28. Parada LF, Land H, Weinberg RA, Wolf D and Rotter V (1984) Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation. Nature 312: 649-651
29. Passlick B, Izbicki JR, Haussinger K, Thetter O and Pantel K (1995) Immunohistochemical detection of p53 protein is not associated with a poor prognosis in non-small-cell lung cancer. J Thorac Cardiovasc Surg 109: 1205-1211
30. Pelo R, Pike MC, Armitage P, Brestlow NE, Cox DR, Howard SV. Mantel N, Mcpherson K, Peto J and Smith PG (1977) Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples. Br J Cancer 35: 1-39
31. Raycroft L, Wu H and Lozano G (1990) Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene. Science 249: 1049-1051
32. Rodenhuis S, Slebos RJC, Boot AJM, Evers SG, Mooi WJ, Wagenaar SS, Van Bodegom PC and Bos JL (1988) Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung. Cancet Res 48: 5738-5741
33. Selvakumaran M, Lin MS, Miyashita T, Wang HG, Krajewski S, Reed JC, Hoffman B and Liebermann D (1994) Immediate early up-regulalion of bax expression by p53 but not TGFβ1: a paradigm for distinct apoptotic pathways. Oncogene 9: 1791-1798
34. Slebos RJC, Kibbelaar RE, Dalesio O, Kooistra A, Stam J, Meijer CJLM, Wagenaar SS, Vanderschueren RGJRA, Van Zandwijk N, Mooi WJ, Bos JL and Rodenhuis S (1990) K-ras oncogene activation as a prognostic marker in adenocarcinoma of the lung. N Engl J Med 323: 561-565
35. Sugio K, Kurata S, Sasaki M, Soejima J and Sasazuki T (1988) Differential expression of c-mye gene and c-fos gene in premalignant and malignant tissues from patients with familial polyposis coli. Cancer Res 48: 4855-4861
36. Sugio K, Ishida T, Yokoyama H, Inoue T, Sugimachi K and Sasazuki T (1992) ras gene mutations as a prognostic marker in adenocarcinoma of human lung without lymph node metastasis. Cancer Res 52: 2903-2906
37. Suzuki H, Takahashi T, Kuroishi T, Suyama M, Ariyoshi Y, Takahashi T and Ueda R (1992) p53 mutations in non-small cell lung cancer in Japan.: association between mutations and smoking. Cancer Res 52: 734-736
38. Weinberg RA (1989) Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis. Cancer Res 49: 3713-3721
39. Xu HJ, Quinlan DC, Davidson AG, Hu SX, Summers CL, Li J and Benedict WF (1994) Altered retinoblastoma protein expression and prognosis in early-stage non-small-cell lung carcinoma. J Natl Cancer Inst 86: 695-699
40. Yancopoulos GD, Nisen PD, Tesfaye A, Kohl NE, Goldfarb MP and Alt FW (1985) N-myc can cooperate with ras to transform normal cells in culture. Proc Natl Acad Sci UVA 82: 5455-5459