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Volumn 226, Issue 2, 2012, Pages 394-403

Notch in the kidney: Development and disease

Author keywords

chronic kidney disease; development; kidney fibrosis; Notch signalling; regeneration; renal cell cancer; repair

Indexed keywords

ADAM PROTEIN; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; JAGGED1; NOTCH RECEPTOR; NOTCH2 RECEPTOR; WNT9B PROTEIN;

EID: 82755160861     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2967     Document Type: Review
Times cited : (115)

References (106)
  • 1
    • 0033617522 scopus 로고    scopus 로고
    • Notch signaling: Cell fate control and signal integration in development
    • DOI 10.1126/science.284.5415.770
    • Artavanis-Tsakonas S, Rand MD, Lake RJ,. Notch signaling: cell fate control and signal integration in development. Science (New York) 1999; 284: 770-776. (Pubitemid 29291335)
    • (1999) Science , vol.284 , Issue.5415 , pp. 770-776
    • Artavanis-Tsakonas, S.1    Rand, M.D.2    Lake, R.J.3
  • 3
    • 64249172203 scopus 로고    scopus 로고
    • The canonical Notch signaling pathway: Unfolding the activation mechanism
    • Kopan R, Ilagan MX,. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell 2009; 137: 216-233.
    • (2009) Cell , vol.137 , pp. 216-233
    • Kopan, R.1    Ilagan, M.X.2
  • 4
    • 33947241465 scopus 로고    scopus 로고
    • SnapShot: Notch signaling pathway
    • Ilagan MX, Kopan R,. SnapShot: notch signaling pathway. Cell 2007; 128: 1246.
    • (2007) Cell , vol.128 , pp. 1246
    • Ilagan, M.X.1    Kopan, R.2
  • 7
    • 0033579505 scopus 로고    scopus 로고
    • Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch
    • Ray WJ, Yao M, Mumm J, et al., Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch. J Biol Chem 1999; 274: 36801-36807.
    • (1999) J Biol Chem , vol.274 , pp. 36801-36807
    • Ray, W.J.1    Yao, M.2    Mumm, J.3
  • 8
    • 0033535504 scopus 로고    scopus 로고
    • A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
    • De Strooper B, Annaert W, Cupers P, et al., A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature 1999; 398: 518-522.
    • (1999) Nature , vol.398 , pp. 518-522
    • De Strooper, B.1    Annaert, W.2    Cupers, P.3
  • 10
    • 0029085935 scopus 로고
    • Signalling downstream of activated mammalian Notch
    • Jarriault S, Brou C, Logeat F, et al., Signalling downstream of activated mammalian Notch. Nature 1995; 377: 355-358.
    • (1995) Nature , vol.377 , pp. 355-358
    • Jarriault, S.1    Brou, C.2    Logeat, F.3
  • 11
    • 0346365362 scopus 로고    scopus 로고
    • Notch1 Signaling Inhibits Growth of Human Hepatocellular Carcinoma through Induction of Cell Cycle Arrest and Apoptosis
    • Qi R, An H, Yu Y, et al., Notch1 signaling inhibits growth of human hepatocellular carcinoma through induction of cell cycle arrest and apoptosis. Cancer Res 2003; 63: 8323-8329. (Pubitemid 37549485)
    • (2003) Cancer Research , vol.63 , Issue.23 , pp. 8323-8329
    • Qi, R.1    An, H.2    Yu, Y.3    Zhang, M.4    Liu, S.5    Xu, H.6    Guo, Z.7    Cheng, T.8    Cao, X.9
  • 12
    • 1842665708 scopus 로고    scopus 로고
    • Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway
    • DOI 10.1016/j.ydbio.2004.01.014, PII S0012160604000636
    • Yang X, Klein R, Tian X, et al., Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Dev Biol 2004; 269: 81-94. (Pubitemid 38471825)
    • (2004) Developmental Biology , vol.269 , Issue.1 , pp. 81-94
    • Yang, X.1    Klein, R.2    Tian, X.3    Cheng, H.-T.4    Kopan, R.5    Shen, J.6
  • 13
    • 24944444760 scopus 로고    scopus 로고
    • Notch promotes survival of pre-T cells at the -selection checkpoint by regulating cellular metabolism
    • DOI 10.1038/ni1234, PII N1234
    • Ciofani M, Zuniga-Pflucker JC,. Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism. Nature Immunol 2005; 6: 881-888. (Pubitemid 43090442)
    • (2005) Nature Immunology , vol.6 , Issue.9 , pp. 881-888
    • Ciofani, M.1    Zuniga-Pflucker, J.C.2
  • 16
    • 58149379347 scopus 로고    scopus 로고
    • Notch and vascular smooth muscle cell phenotype
    • Morrow D, Guha S, Sweeney C, et al., Notch and vascular smooth muscle cell phenotype. Circ Res 2008; 103: 1370-1382.
    • (2008) Circ Res , vol.103 , pp. 1370-1382
    • Morrow, D.1    Guha, S.2    Sweeney, C.3
  • 18
    • 0034210603 scopus 로고    scopus 로고
    • Characterization of the human and mouse HEY1, HEY2, and HEYL genes: Cloning, mapping, and mutation screening of a new bHLH gene family
    • DOI 10.1006/geno.2000.6200
    • Steidl C, Leimeister C, Klamt B, et al., Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family. Genomics 2000; 66: 195-203. (Pubitemid 30429754)
    • (2000) Genomics , vol.66 , Issue.2 , pp. 195-203
    • Steidl, C.1    Leimeister, C.2    Klamt, B.3    Maier, M.4    Nanda, I.5    Dixon, M.6    Clarke, R.7    Schmid, M.8    Gessler, M.9
  • 19
    • 0032947595 scopus 로고    scopus 로고
    • Screen for genes regulated during early kidney morphogenesis
    • DOI 10.1002/(SICI)1520-6408(1999)24:3/4<273::AID-DVG10>3.0.CO;2-3
    • Leimeister C, Bach A, Woolf AS, et al., Screen for genes regulated during early kidney morphogenesis. Dev Genet 1999; 24: 273-283. (Pubitemid 29211791)
    • (1999) Developmental Genetics , vol.24 , Issue.3-4 , pp. 273-283
    • Leimeister, C.1    Bach, A.2    Woolf, A.S.3    Gessler, M.4
  • 20
    • 78049449123 scopus 로고    scopus 로고
    • Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans
    • Bielesz B, Sirin Y, Si H, et al., Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans. J Clin Invest 2010; 120: 4040-4054.
    • (2010) J Clin Invest , vol.120 , pp. 4040-4054
    • Bielesz, B.1    Sirin, Y.2    Si, H.3
  • 21
    • 4444293744 scopus 로고    scopus 로고
    • Notch signaling in mammary development and oncogenesis
    • DOI 10.1023/B:JOMG.0000037159.63644.81, Embryonic Genes in Mammary Gland Development and Tumorigenesis
    • Callahan R, Egan SE,. Notch signaling in mammary development and oncogenesis. J Mammary Gland Biol Neoplasia 2004; 9: 145-163. (Pubitemid 39177500)
    • (2004) Journal of Mammary Gland Biology and Neoplasia , vol.9 , Issue.2 , pp. 145-163
    • Callahan, R.1    Egan, S.E.2
  • 22
    • 20444467287 scopus 로고    scopus 로고
    • Mind bomb-2 is an E3 ligase for Notch ligand
    • Koo BK, Yoon KJ, Yoo KW, et al., Mind bomb-2 is an E3 ligase for Notch ligand. J Biol Chem 2005; 280: 22335-22342.
    • (2005) J Biol Chem , vol.280 , pp. 22335-22342
    • Koo, B.K.1    Yoon, K.J.2    Yoo, K.W.3
  • 23
    • 43249100317 scopus 로고    scopus 로고
    • An obligatory role of mind bomb-1 in notch signaling of mammalian development
    • Koo BK, Yoon MJ, Yoon KJ, et al., An obligatory role of mind bomb-1 in notch signaling of mammalian development. PLoS One 2007; 2: e1221.
    • (2007) PLoS One , vol.2
    • Koo, B.K.1    Yoon, M.J.2    Yoon, K.J.3
  • 24
    • 79955460636 scopus 로고    scopus 로고
    • Notch signalling in solid tumours: A little bit of everything but not all the time
    • Ranganathan P, Weaver KL, Capobianco AJ,. Notch signalling in solid tumours: a little bit of everything but not all the time. Nature Rev Cancer 2011; 11: 338-351.
    • (2011) Nature Rev Cancer , vol.11 , pp. 338-351
    • Ranganathan, P.1    Weaver, K.L.2    Capobianco, A.J.3
  • 25
    • 65549121943 scopus 로고    scopus 로고
    • Notch signaling: The core pathway and its posttranslational regulation
    • Fortini ME,. Notch signaling: the core pathway and its posttranslational regulation. Dev Cell 2009; 16: 633-647.
    • (2009) Dev Cell , vol.16 , pp. 633-647
    • Fortini, M.E.1
  • 26
    • 0029901697 scopus 로고    scopus 로고
    • Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene
    • DOI 10.1038/382133a0
    • Kim J, Sebring A, Esch JJ, et al., Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene. Nature 1996; 382: 133-138. (Pubitemid 26242872)
    • (1996) Nature , vol.382 , Issue.6587 , pp. 133-138
    • Kim, J.1    Sebring, A.2    Esch, J.J.3    Kraus, M.E.4    Vorwerk, K.5    Magee, J.6    Carroll, S.B.7
  • 27
    • 1642382833 scopus 로고    scopus 로고
    • Notch signaling: Control of cell communication and cell fate
    • DOI 10.1242/dev.01074
    • Lai EC,. Notch signaling: control of cell communication and cell fate. Development 2004; 131: 965-973. (Pubitemid 38380451)
    • (2004) Development , vol.131 , Issue.5 , pp. 965-973
    • Lai, E.C.1
  • 28
    • 0030273294 scopus 로고    scopus 로고
    • The Notch pathway: Democracy and aristocracy in the selection of cell fate
    • DOI 10.1016/S0959-4388(96)80090-0
    • Kopan R, Turner DL,. The Notch pathway: democracy and aristocracy in the selection of cell fate. Curr Opin Neurobiol 1996; 6: 594-601. (Pubitemid 26387712)
    • (1996) Current Opinion in Neurobiology , vol.6 , Issue.5 , pp. 594-601
    • Kopan, R.1    Turner, D.L.2
  • 29
    • 0027966977 scopus 로고
    • An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells
    • Nye JS, Kopan R, Axel R,. An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells. Development 1994; 120: 2421-2430. (Pubitemid 24268817)
    • (1994) Development , vol.120 , Issue.9 , pp. 2421-2430
    • Nye, J.S.1    Kopan, R.2    Axel, R.3
  • 30
    • 0027991383 scopus 로고
    • The intracellular domain of mouse Notch: A constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD
    • Kopan R, Nye JS, Weintraub H,. The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD. Development 1994; 120: 2385-2396. (Pubitemid 24268814)
    • (1994) Development , vol.120 , Issue.9 , pp. 2385-2396
    • Kopan, R.1    Nye, J.S.2    Weintraub, H.3
  • 31
    • 0030914459 scopus 로고    scopus 로고
    • Mutations in the human Jagged1 gene are responsible for Alagille syndrome
    • Oda T, Elkahloun AG, Pike BL, et al., Mutations in the human Jagged1 gene are responsible for Alagille syndrome. Nature Genet 1997; 16: 235-242.
    • (1997) Nature Genet , vol.16 , pp. 235-242
    • Oda, T.1    Elkahloun, A.G.2    Pike, B.L.3
  • 32
    • 0038875342 scopus 로고    scopus 로고
    • Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1
    • Li L, Krantz ID, Deng Y, et al., Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1. Nature Genet 1997; 16: 243-251.
    • (1997) Nature Genet , vol.16 , pp. 243-251
    • Li, L.1    Krantz, I.D.2    Deng, Y.3
  • 34
    • 0023148932 scopus 로고
    • Syndromic paucity of interlobular bile ducts (Alagille syndrome or arteriohepatic dysplasia): Review of 80 cases
    • DOI 10.1016/S0022-3476(87)80153-1
    • Alagille D, Estrada A, Hadchouel M, et al., Syndromic paucity of interlobular bile ducts (Alagille syndrome or arteriohepatic dysplasia): review of 80 cases. J Pediatr 1987; 110: 195-200. (Pubitemid 17016845)
    • (1987) Journal of Pediatrics , vol.110 , Issue.2 , pp. 195-200
    • Alagille, D.1    Estrada, A.2    Hadchouel, M.3
  • 35
    • 0016439420 scopus 로고
    • Hepatic ductular hypoplasia associated with characteristic facies, vertebral malformations, retarded physical, mental, and sexual development, and cardiac murmur
    • Alagille D, Odievre M, Gautier M, et al., Hepatic ductular hypoplasia associated with characteristic facies, vertebral malformations, retarded physical, mental, and sexual development, and cardiac murmur. J Pediatr 1975; 86: 63-71.
    • (1975) J Pediatr , vol.86 , pp. 63-71
    • Alagille, D.1    Odievre, M.2    Gautier, M.3
  • 36
    • 27144512319 scopus 로고    scopus 로고
    • Jagged1 signals in the postnatal subventricular zone are required for neural stem cell self-renewal
    • DOI 10.1038/sj.emboj.7600816, PII 7600816
    • Nyfeler Y, Kirch RD, Mantei N, et al., Jagged1 signals in the postnatal subventricular zone are required for neural stem cell self-renewal. EMBO J 2005; 24: 3504-3515. (Pubitemid 41486787)
    • (2005) EMBO Journal , vol.24 , Issue.19 , pp. 3504-3515
    • Nyfeler, Y.1    Kirch, R.D.2    Mantei, N.3    Leone, D.P.4    Radtke, F.5    Suter, U.6    Taylor, V.7
  • 37
    • 34548787844 scopus 로고    scopus 로고
    • Renal abnormalities and their developmental origin
    • DOI 10.1038/nrg2205, PII NRG2205
    • Schedl A,. Renal abnormalities and their developmental origin. Nature Rev 2007; 8: 791-802. (Pubitemid 47429212)
    • (2007) Nature Reviews Genetics , vol.8 , Issue.10 , pp. 791-802
    • Schedl, A.1
  • 38
    • 77952946956 scopus 로고    scopus 로고
    • Patterning a complex organ: Branching morphogenesis and nephron segmentation in kidney development
    • Costantini F, Kopan R,. Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development. Dev Cell 2010; 18: 698-712.
    • (2010) Dev Cell , vol.18 , pp. 698-712
    • Costantini, F.1    Kopan, R.2
  • 39
    • 2142763932 scopus 로고    scopus 로고
    • Morphogenesis of the metanephric kidney
    • Davies JA,. Morphogenesis of the metanephric kidney. Sci World J 2002; 2: 1937-1950.
    • (2002) Sci World J , vol.2 , pp. 1937-1950
    • Davies, J.A.1
  • 43
    • 15844426332 scopus 로고    scopus 로고
    • Defects in enteric innervation and kidney development in mice lacking GDNF
    • Pichel JG, Shen L, Sheng HZ, et al., Defects in enteric innervation and kidney development in mice lacking GDNF. Nature 1996; 382: 73-76.
    • (1996) Nature , vol.382 , pp. 73-76
    • Pichel, J.G.1    Shen, L.2    Sheng, H.Z.3
  • 44
    • 0029901727 scopus 로고    scopus 로고
    • Renal agenesis and the absence of enteric neurons in mice lacking GDNF
    • DOI 10.1038/382070a0
    • Sanchez MP, Silos-Santiago I, Frisen J, et al., Renal agenesis and the absence of enteric neurons in mice lacking GDNF. Nature 1996; 382: 70-73. (Pubitemid 26243359)
    • (1996) Nature , vol.382 , Issue.6586 , pp. 70-73
    • Sanchez, M.P.1    Silos-Santiago, I.2    Frisen, J.3    He, B.4    Lira, S.A.5    Barbacid, M.6
  • 45
    • 22944463010 scopus 로고    scopus 로고
    • Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system
    • DOI 10.1016/j.devcel.2005.05.016, PII S1534580705001863
    • Carroll TJ, Park JS, Hayashi S, et al., Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Dev Cell 2005; 9: 283-292. (Pubitemid 41051746)
    • (2005) Developmental Cell , vol.9 , Issue.2 , pp. 283-292
    • Carroll, T.J.1    Park, J.-S.2    Hayashi, S.3    Majumdar, A.4    McMahon, A.P.5
  • 46
    • 0028588919 scopus 로고
    • Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4
    • Stark K, Vainio S, Vassileva G, et al., Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4. Nature 1994; 372: 679-683.
    • (1994) Nature , vol.372 , pp. 679-683
    • Stark, K.1    Vainio, S.2    Vassileva, G.3
  • 47
    • 0043172526 scopus 로고    scopus 로고
    • Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development
    • Majumdar A, Vainio S, Kispert A, et al., Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development. Development 2003; 130: 3175-3185. (Pubitemid 36926955)
    • (2003) Development , vol.130 , Issue.14 , pp. 3175-3185
    • Majumdar, A.1    Vainio, S.2    Kispert, A.3    McMahon, J.4    McMahon, A.P.5
  • 49
    • 4744354539 scopus 로고    scopus 로고
    • Expression of Hairy/Enhancer of Split genes, Hes1 and Hes5, during murine nephron morphogenesis
    • DOI 10.1016/j.modgep.2004.04.007, PII S1567133X04000638
    • Piscione TD, Wu MY, Quaggin SE,. Expression of Hairy/Enhancer of Split genes, Hes1 and Hes5, during murine nephron morphogenesis. Gene Expr Patterns 2004; 4: 707-711. (Pubitemid 39307534)
    • (2004) Gene Expression Patterns , vol.4 , Issue.6 , pp. 707-711
    • Piscione, T.D.1    Wu, M.Y.J.2    Quaggin, S.E.3
  • 50
    • 0037230145 scopus 로고    scopus 로고
    • Notch signaling in kidney development
    • DOI 10.1097/00041552-200301000-00002
    • McCright B,. Notch signaling in kidney development. Curr Opin Nephrol Hypertens 2003; 12: 5-10. (Pubitemid 36092308)
    • (2003) Current Opinion in Nephrology and Hypertension , vol.12 , Issue.1 , pp. 5-10
    • McCright, B.1
  • 52
    • 0036339631 scopus 로고    scopus 로고
    • A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency
    • McCright B, Lozier J, Gridley T,. A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency. Development 2002; 129: 1075-1082. (Pubitemid 34874130)
    • (2002) Development , vol.129 , Issue.4 , pp. 1075-1082
    • McCright, B.1    Lozier, J.2    Gridley, T.3
  • 53
    • 0142243064 scopus 로고    scopus 로고
    • Presenilins are required for the formation of comma- and S-shaped bodies during nephrogenesis
    • DOI 10.1242/dev.00682
    • Wang P, Pereira FA, Beasley D, et al., Presenilins are required for the formation of comma- and S-shaped bodies during nephrogenesis. Development 2003; 130: 5019-5029. (Pubitemid 37321883)
    • (2003) Development , vol.130 , Issue.20 , pp. 5019-5029
    • Wang, P.1    Pereira, F.A.2    Beasley, D.3    Zheng, H.4
  • 54
    • 30944438698 scopus 로고    scopus 로고
    • The role of Notch signaling in specification of podocyte and proximal tubules within the developing mouse kidney
    • DOI 10.1111/j.1523-1755.2005.00627.x, PII 4494817
    • Cheng HT, Kopan R,. The role of Notch signaling in specification of podocyte and proximal tubules within the developing mouse kidney. Kidney Int 2005; 68: 1951-1952. (Pubitemid 43117769)
    • (2005) Kidney International , vol.68 , Issue.5 , pp. 1951-1952
    • Cheng, H.-T.1    Kopan, R.2
  • 55
    • 0142180318 scopus 로고    scopus 로고
    • Secretase activity is dispensable for mesenchyme-to-epithelium transition but required for podocyte and proximal tubule formation in developing mouse kidney
    • DOI 10.1242/dev.00697
    • Cheng HT, Miner JH, Lin M, et al., Gamma-secretase activity is dispensable for mesenchyme-to-epithelium transition but required for podocyte and proximal tubule formation in developing mouse kidney. Development 2003; 130: 5031-5042. (Pubitemid 37321884)
    • (2003) Development , vol.130 , Issue.20 , pp. 5031-5042
    • Cheng, H.-T.1    Miner, J.H.2    Lin, M.3    Tansey, M.G.4    Roth, K.5    Kopan, R.6
  • 57
    • 72649098088 scopus 로고    scopus 로고
    • The contribution of Notch1 to nephron segmentation in the developing kidney is revealed in a sensitized Notch2 background and can be augmented by reducing Mint dosage
    • Surendran K, Boyle S, Barak H, et al., The contribution of Notch1 to nephron segmentation in the developing kidney is revealed in a sensitized Notch2 background and can be augmented by reducing Mint dosage. Dev Biol 2010; 337: 386-395.
    • (2010) Dev Biol , vol.337 , pp. 386-395
    • Surendran, K.1    Boyle, S.2    Barak, H.3
  • 58
    • 79955624322 scopus 로고    scopus 로고
    • The fate of Notch-deficient nephrogenic progenitor cells during metanephric kidney development
    • Bonegio RG, Beck LH, Kahlon RK, et al., The fate of Notch-deficient nephrogenic progenitor cells during metanephric kidney development. Kidney Int 2010; 79: 1099-1112.
    • (2010) Kidney Int , vol.79 , pp. 1099-1112
    • Bonegio, R.G.1    Beck, L.H.2    Kahlon, R.K.3
  • 59
    • 77952561091 scopus 로고    scopus 로고
    • Notch2 activation in the embryonic kidney depletes nephron progenitors
    • Fujimura S, Jiang Q, Kobayashi C, et al., Notch2 activation in the embryonic kidney depletes nephron progenitors. J Am Soc Nephrol 2010; 21: 803-810.
    • (2010) J Am Soc Nephrol , vol.21 , pp. 803-810
    • Fujimura, S.1    Jiang, Q.2    Kobayashi, C.3
  • 60
    • 80052288489 scopus 로고    scopus 로고
    • Nephron progenitors in the metanephric mesenchyme
    • Nishinakamura R, Uchiyama Y, Sakaguchi M, et al., Nephron progenitors in the metanephric mesenchyme. Pediatr Nephrol 2011; 26: 1463-1467.
    • (2011) Pediatr Nephrol , vol.26 , pp. 1463-1467
    • Nishinakamura, R.1    Uchiyama, Y.2    Sakaguchi, M.3
  • 61
    • 0022728421 scopus 로고
    • Structural-functional relationship along the distal nephron
    • Madsen KM, Tisher CC,. Structural-functional relationship along the distal nephron. Am J Physiol 1986; 250: F1-15.
    • (1986) Am J Physiol , vol.250
    • Madsen, K.M.1    Tisher, C.C.2
  • 63
    • 70449426676 scopus 로고    scopus 로고
    • Inactivation of Notch signaling in the renal collecting duct causes nephrogenic diabetes insipidus in mice
    • Jeong HW, Jeon US, Koo BK, et al., Inactivation of Notch signaling in the renal collecting duct causes nephrogenic diabetes insipidus in mice. J Clin Invest 2009; 119: 3290-3300.
    • (2009) J Clin Invest , vol.119 , pp. 3290-3300
    • Jeong, H.W.1    Jeon, U.S.2    Koo, B.K.3
  • 64
    • 34247391176 scopus 로고    scopus 로고
    • Notch signaling controls the differentiation of transporting epithelia and multiciliated cells in the zebrafish pronephros
    • DOI 10.1242/dev.02806
    • Liu Y, Pathak N, Kramer-Zucker A, et al., Notch signaling controls the differentiation of transporting epithelia and multiciliated cells in the zebrafish pronephros. Development 2007; 134: 1111-1122. (Pubitemid 46630079)
    • (2007) Development , vol.134 , Issue.6 , pp. 1111-1122
    • Liu, Y.1    Pathak, N.2    Kramer-Zucker, A.3    Drummond, I.A.4
  • 65
    • 33846501407 scopus 로고    scopus 로고
    • Jagged2a-notch signaling mediates cell fate choice in the zebrafish pronephric duct
    • Ma M, Jiang YJ,. Jagged2a-notch signaling mediates cell fate choice in the zebrafish pronephric duct. PLoS Genet 2007; 3: e18.
    • (2007) PLoS Genet , vol.3
    • Ma, M.1    Jiang, Y.J.2
  • 66
    • 77952556128 scopus 로고    scopus 로고
    • Reduced Notch signaling leads to renal cysts and papillary microadenomas
    • Surendran K, Selassie M, Liapis H, et al., Reduced Notch signaling leads to renal cysts and papillary microadenomas. J Am Soc Nephrol 2010; 21: 819-832.
    • (2010) J Am Soc Nephrol , vol.21 , pp. 819-832
    • Surendran, K.1    Selassie, M.2    Liapis, H.3
  • 69
    • 77951587507 scopus 로고    scopus 로고
    • Acute kidney injury: A springboard for progression in chronic kidney disease
    • Venkatachalam MA, Griffin KA, Lan R, et al., Acute kidney injury: a springboard for progression in chronic kidney disease. Am J Physiol Renal Physiol 2010; 298: F1078-F1094.
    • (2010) Am J Physiol Renal Physiol , vol.298
    • Venkatachalam, M.A.1    Griffin, K.A.2    Lan, R.3
  • 71
    • 74049111571 scopus 로고    scopus 로고
    • Effect of Notch activation on the regenerative response to acute renal failure
    • Gupta S, Li S, Abedin MJ, et al., Effect of Notch activation on the regenerative response to acute renal failure. Am J Physiol 2010; 298: F209-F215.
    • (2010) Am J Physiol , vol.298
    • Gupta, S.1    Li, S.2    Abedin, M.J.3
  • 73
    • 77955654604 scopus 로고    scopus 로고
    • Expression of Notch pathway proteins correlates with albuminuria, glomerulosclerosis, and renal function
    • Murea M, Park JK, Sharma S, et al., Expression of Notch pathway proteins correlates with albuminuria, glomerulosclerosis, and renal function. Kidney Int 2010; 78: 514-522.
    • (2010) Kidney Int , vol.78 , pp. 514-522
    • Murea, M.1    Park, J.K.2    Sharma, S.3
  • 74
    • 67649099271 scopus 로고    scopus 로고
    • The pathogenic role of notch activation in podocytes
    • Niranjan T, Murea M, Susztak K,. The pathogenic role of notch activation in podocytes. Nephron 2009; 111: e73-e79.
    • (2009) Nephron , vol.111
    • Niranjan, T.1    Murea, M.2    Susztak, K.3
  • 75
    • 1842524153 scopus 로고    scopus 로고
    • Integration of TGF-/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition
    • DOI 10.1038/sj.emboj.7600069
    • Zavadil J, Cermak L, Soto-Nieves N, et al., Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition. EMBO J 2004; 23: 1155-1165. (Pubitemid 38436879)
    • (2004) EMBO Journal , vol.23 , Issue.5 , pp. 1155-1165
    • Zavadil, J.1    Cermak, L.2    Soto-Nieves, N.3    Bottinger, E.P.4
  • 77
    • 79957637197 scopus 로고    scopus 로고
    • Notch signalling regulates fibroblast activation and collagen release in systemic sclerosis
    • Dees C, Tomcik M, Zerr P, et al., Notch signalling regulates fibroblast activation and collagen release in systemic sclerosis. Ann Rheum Dis 2011; 70: 1304-1310.
    • (2011) Ann Rheum Dis , vol.70 , pp. 1304-1310
    • Dees, C.1    Tomcik, M.2    Zerr, P.3
  • 78
    • 79955567838 scopus 로고    scopus 로고
    • Inhibition of Notch signaling prevents experimental fibrosis and induces regression of established fibrosis
    • Dees C, Zerr P, Tomcik M, et al., Inhibition of Notch signaling prevents experimental fibrosis and induces regression of established fibrosis. Arthr Rheum 2011; 63: 1396-1404.
    • (2011) Arthr Rheum , vol.63 , pp. 1396-1404
    • Dees, C.1    Zerr, P.2    Tomcik, M.3
  • 79
    • 76149087167 scopus 로고    scopus 로고
    • Preventive effect of Notch signaling inhibition by a gamma-secretase inhibitor on peritoneal dialysis fluid-induced peritoneal fibrosis in rats
    • Zhu F, Li T, Qiu F, et al., Preventive effect of Notch signaling inhibition by a gamma-secretase inhibitor on peritoneal dialysis fluid-induced peritoneal fibrosis in rats. Am J Pathol 2010; 176: 650-659.
    • (2010) Am J Pathol , vol.176 , pp. 650-659
    • Zhu, F.1    Li, T.2    Qiu, F.3
  • 80
    • 77956227414 scopus 로고    scopus 로고
    • Activation of Notch signaling pathway in HIV-associated nephropathy
    • Sharma M, Callen S, Zhang D, et al., Activation of Notch signaling pathway in HIV-associated nephropathy. AIDS 2011; 24: 2161-2170.
    • (2011) AIDS , vol.24 , pp. 2161-2170
    • Sharma, M.1    Callen, S.2    Zhang, D.3
  • 81
    • 39149086711 scopus 로고    scopus 로고
    • Co-regulation of Gremlin and Notch signalling in diabetic nephropathy
    • Walsh DW, Roxburgh SA, McGettigan P, et al., Co-regulation of Gremlin and Notch signalling in diabetic nephropathy. Biochim Biophys Acta 2008; 1782: 10-21.
    • (2008) Biochim Biophys Acta , vol.1782 , pp. 10-21
    • Walsh, D.W.1    Roxburgh, S.A.2    McGettigan, P.3
  • 82
    • 77957857754 scopus 로고    scopus 로고
    • Notch activation regulates differentially renal progenitors proliferation and differentiation toward the podocyte lineage in glomerular disorders
    • Lasagni L, Ballerini L, Angelotti ML, et al., Notch activation regulates differentially renal progenitors proliferation and differentiation toward the podocyte lineage in glomerular disorders. Stem Cells 2010; 28: 1674-1685.
    • (2010) Stem Cells , vol.28 , pp. 1674-1685
    • Lasagni, L.1    Ballerini, L.2    Angelotti, M.L.3
  • 83
    • 22844440114 scopus 로고    scopus 로고
    • Notch signaling in the mammalian central nervous system: Insights from mouse mutants
    • DOI 10.1038/nn1475, PII NN1475
    • Yoon K, Gaiano N,. Notch signaling in the mammalian central nervous system: insights from mouse mutants. Nature Neurosci 2005; 8: 709-715. (Pubitemid 43085834)
    • (2005) Nature Neuroscience , vol.8 , Issue.6 , pp. 709-715
    • Yoon, K.1    Gaiano, N.2
  • 84
    • 79952213043 scopus 로고    scopus 로고
    • Notch in the vertebrate nervous system: An old dog with new tricks
    • Pierfelice T, Alberi L, Gaiano N,. Notch in the vertebrate nervous system: an old dog with new tricks. Neuron 2011; 69: 840-855.
    • (2011) Neuron , vol.69 , pp. 840-855
    • Pierfelice, T.1    Alberi, L.2    Gaiano, N.3
  • 85
    • 77955395425 scopus 로고    scopus 로고
    • Getting a notch closer to understanding diabetic kidney disease
    • Ahn SH, Susztak K,. Getting a notch closer to understanding diabetic kidney disease. Diabetes 2010; 59: 1865-1867.
    • (2010) Diabetes , vol.59 , pp. 1865-1867
    • Ahn, S.H.1    Susztak, K.2
  • 86
    • 77955366446 scopus 로고    scopus 로고
    • Modulation of notch-1 signaling alleviates vascular endothelial growth factor-mediated diabetic nephropathy
    • Lin CL, Wang FS, Hsu YC, et al., Modulation of notch-1 signaling alleviates vascular endothelial growth factor-mediated diabetic nephropathy. Diabetes 2010; 59: 1915-1925.
    • (2010) Diabetes , vol.59 , pp. 1915-1925
    • Lin, C.L.1    Wang, F.S.2    Hsu, Y.C.3
  • 87
    • 38349095890 scopus 로고    scopus 로고
    • Targeting Notch signaling in autoimmune and lymphoproliferative disease
    • Teachey DT, Seif AE, Brown VI, et al., Targeting Notch signaling in autoimmune and lymphoproliferative disease. Blood 2008; 111: 705-714.
    • (2008) Blood , vol.111 , pp. 705-714
    • Teachey, D.T.1    Seif, A.E.2    Brown, V.I.3
  • 89
    • 45849147350 scopus 로고    scopus 로고
    • A Molecule Targeting VHL-Deficient Renal Cell Carcinoma that Induces Autophagy
    • DOI 10.1016/j.ccr.2008.06.004, PII S1535610808001943
    • Turcotte S, Chan DA, Sutphin PD, et al., A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy. Cancer Cell 2008; 14: 90-102. (Pubitemid 351885499)
    • (2008) Cancer Cell , vol.14 , Issue.1 , pp. 90-102
    • Turcotte, S.1    Chan, D.A.2    Sutphin, P.D.3    Hay, M.P.4    Denny, W.A.5    Giaccia, A.J.6
  • 91
    • 74949090816 scopus 로고    scopus 로고
    • The evolutionarily conserved TSC/Rheb pathway activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development
    • Karbowniczek M, Zitserman D, Khabibullin D, et al., The evolutionarily conserved TSC/Rheb pathway activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development. J Clin Invest 2010; 120: 93-102.
    • (2010) J Clin Invest , vol.120 , pp. 93-102
    • Karbowniczek, M.1    Zitserman, D.2    Khabibullin, D.3
  • 92
    • 22144498100 scopus 로고    scopus 로고
    • Tuberose sclerosis complex: Analysis of growth rates aids differentiation of renal cell carcinoma from atypical or minimal-fat-containing angiomyolipoma
    • DOI 10.1016/j.crad.2005.01.009, PII S0009926005000279
    • Patel U, Simpson E, Kingswood JC, et al., Tuberose sclerosis complex: analysis of growth rates aids differentiation of renal cell carcinoma from atypical or minimal-fat-containing angiomyolipoma. Clin Radiol 2005; 60: 665-673; discussion 663-664. (Pubitemid 40984061)
    • (2005) Clinical Radiology , vol.60 , Issue.6 , pp. 665-673
    • Patel, U.1    Simpson, E.2    Kingswood, J.C.3    Saggar-Malik, A.K.4
  • 93
    • 79955045668 scopus 로고    scopus 로고
    • Expression of Notch1 to -4 and their ligands in renal cell carcinoma: A tissue microarray study
    • Aparicio LM, Villaamil VM, Gallego GA, et al., Expression of Notch1 to -4 and their ligands in renal cell carcinoma: a tissue microarray study. Cancer Genom Proteom 2011; 8: 93-101.
    • (2011) Cancer Genom Proteom , vol.8 , pp. 93-101
    • Aparicio, L.M.1    Villaamil, V.M.2    Gallego, G.A.3
  • 94
    • 0034574386 scopus 로고    scopus 로고
    • Novel association of a diverse range of genes with renal cell carcinoma as identified by differential display
    • Rae FK, Stephenson SA, Nicol DL, et al., Novel association of a diverse range of genes with renal cell carcinoma as identified by differential display. Int J Cancer 2000; 88: 726-732.
    • (2000) Int J Cancer , vol.88 , pp. 726-732
    • Rae, F.K.1    Stephenson, S.A.2    Nicol, D.L.3
  • 95
    • 68849097965 scopus 로고    scopus 로고
    • Expression and clinical significance of Notch receptors in human renal cell carcinoma
    • Sun S, Du R, Gao J, et al., Expression and clinical significance of Notch receptors in human renal cell carcinoma. Pathology 2009; 41: 335-341.
    • (2009) Pathology , vol.41 , pp. 335-341
    • Sun, S.1    Du, R.2    Gao, J.3
  • 97
    • 38149015554 scopus 로고    scopus 로고
    • Suppression of renal cell carcinoma growth by inhibition of Notch signaling in vitro and in vivo
    • Sjolund J, Johansson M, Manna S, et al., Suppression of renal cell carcinoma growth by inhibition of Notch signaling in vitro and in vivo. J Clin Invest 2008; 118: 217-228.
    • (2008) J Clin Invest , vol.118 , pp. 217-228
    • Sjolund, J.1    Johansson, M.2    Manna, S.3
  • 98
    • 56049114427 scopus 로고    scopus 로고
    • KyoT3, an isoform of murine FHL1, associates with the transcription factor RBP-J and represses the RBP-J-mediated transactivation
    • Liang L, Zhang HW, Liang J, et al., KyoT3, an isoform of murine FHL1, associates with the transcription factor RBP-J and represses the RBP-J-mediated transactivation. Biochim Biophys Acta 2008; 1779: 805-810.
    • (2008) Biochim Biophys Acta , vol.1779 , pp. 805-810
    • Liang, L.1    Zhang, H.W.2    Liang, J.3
  • 101
    • 0036833437 scopus 로고    scopus 로고
    • Therapeutic strategies for Alzheimer's disease
    • DOI 10.1038/nrd938
    • Wolfe MS,. Therapeutic strategies for Alzheimer's disease. Nature Rev Drug Discov 2002; 1: 859-866. (Pubitemid 37361581)
    • (2002) Nature Reviews Drug Discovery , vol.1 , Issue.11 , pp. 859-866
    • Wolfe, M.S.1
  • 102
    • 0036675744 scopus 로고    scopus 로고
    • Continuing strategies for inhibiting Alzheimer's secretase
    • Wolfe MS, Esler WP, Das C,. Continuing strategies for inhibiting Alzheimer's gamma-secretase. J Mol Neurosci 2002; 19: 83-87. (Pubitemid 35013338)
    • (2002) Journal of Molecular Neuroscience , vol.19 , Issue.1-2 , pp. 83-87
    • Wolfe, M.S.1    Esler, W.P.2    Das, C.3
  • 103
    • 0036266624 scopus 로고    scopus 로고
    • The search for gamma-secretase and development of inhibitors
    • Tsai JY, Wolfe MS, Xia W,. The search for gamma-secretase and development of inhibitors. Curr Med Chem 2002; 9: 1087-1106.
    • (2002) Curr Med Chem , vol.9 , pp. 1087-1106
    • Tsai, J.Y.1    Wolfe, M.S.2    Xia, W.3
  • 105
    • 77951139188 scopus 로고    scopus 로고
    • Therapeutic antibody targeting of individual Notch receptors
    • Wu Y, Cain-Hom C, Choy L, et al., Therapeutic antibody targeting of individual Notch receptors. Nature 2010; 464: 1052-1057.
    • (2010) Nature , vol.464 , pp. 1052-1057
    • Wu, Y.1    Cain-Hom, C.2    Choy, L.3
  • 106
    • 58149336788 scopus 로고    scopus 로고
    • Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia
    • Real PJ, Tosello V, Palomero T, et al., Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia. Nature Med 2009; 15: 50-58.
    • (2009) Nature Med , vol.15 , pp. 50-58
    • Real, P.J.1    Tosello, V.2    Palomero, T.3


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