Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans

Journal of Clinical Investigation

Volumn 120, Issue 11, 2010, Pages 4040-4054

  Bielesz, Bernhard ^a   Sirin, Yasemin ^a,b   Si, Han ^a   Niranjan, Thiruvur ^a   Gruenwald, Antje ^a   Ahn, Seonho ^a   Kato, Hideki ^a   Pullman, James ^a   Gessler, Manfred ^c   Haase, Volker H ^d   Susztak, Katalin ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^c UNIVERSITY OF WÜRZBURG   (Germany)

^d VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA SECRETASE INHIBITOR; MESSENGER RNA; NOTCH1 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; ENZYME INHIBITION; EPITHELIUM CELL; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; KIDNEY TUBULE DISORDER; KIDNEY TUBULE EPITHELIUM; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUBULOINTERSTITIAL FIBROSIS;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CALCIUM-BINDING PROTEINS; CELL PROLIFERATION; EPITHELIAL CELLS; FIBROSIS; HOMEODOMAIN PROTEINS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY; KIDNEY FAILURE, CHRONIC; KIDNEY TUBULES; MALE; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; NEPHRITIS, INTERSTITIAL; RECEPTOR, NOTCH1; SIGNAL TRANSDUCTION;

EID: 78049449123     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI43025     Document Type: Article

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