메뉴 건너뛰기




Volumn 6, Issue 12, 2011, Pages 1521-1533

The role of Toll-like receptors and adaptive immunity in the development of protective or pathological immune response triggered by the Trypanosoma cruzi protozoan

Author keywords

B cells; Cytokines; Macrophages; Pathogenesis; TLR; Trypanosoma cruzi

Indexed keywords

CRUZIPAIN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 6; MYELOID DIFFERENTIATION FACTOR 88; PARASITE ANTIGEN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 9; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

EID: 82455192479     PISSN: 17460913     EISSN: 17460921     Source Type: Journal    
DOI: 10.2217/fmb.11.122     Document Type: Review
Times cited : (21)

References (103)
  • 2
    • 53149148909 scopus 로고    scopus 로고
    • Chagas heart disease pathogenesis: one mechanism or many
    • Bonney KM, Engman DM. Chagas heart disease pathogenesis: one mechanism or many? Curr. Mol. Med. 8(6), 510-518 (2008).
    • (2008) Curr. Mol. Med. , vol.8 , Issue.6 , pp. 510-518
    • Bonney, K.M.1    Engman, D.M.2
  • 3
    • 0141917119 scopus 로고    scopus 로고
    • The significance of autoimmunity in the pathogenesis of Chagas heart disease
    • Leon JS, Engman DM. The significance of autoimmunity in the pathogenesis of Chagas heart disease. Front. Biosci. 8, e315-e322 (2003).
    • (2003) Front. Biosci. , vol.8
    • Leon, J.S.1    Engman, D.M.2
  • 6
    • 33947126485 scopus 로고    scopus 로고
    • Cytokines and cell adhesion receptors in the regulation of immunity to Trypanosoma cruzi
    • Savino W, Villa-Verde DM, Mendes-da-Cruz DA et al. Cytokines and cell adhesion receptors in the regulation of immunity to Trypanosoma cruzi. Cytokine Growth Factor Rev. 18(1-2), 107-124 (2007).
    • (2007) Cytokine Growth Factor Rev. , vol.18 , Issue.1-2 , pp. 107-124
    • Savino, W.1    Villa-Verde, D.M.2    Mendes-Da-Cruz, D.A.3
  • 7
    • 70349967303 scopus 로고    scopus 로고
    • The role of parasite persistence in pathogenesis of Chagas heart disease
    • Gutierrez FR, Guedes PM, Gazzinelli RT, Silva JS. The role of parasite persistence in pathogenesis of Chagas heart disease. Parasite Immunol. 31(11), 673-685 (2009).
    • (2009) Parasite Immunol. , vol.31 , Issue.11 , pp. 673-685
    • Gutierrez, F.R.1    Guedes, P.M.2    Gazzinelli, R.T.3    Silva, J.S.4
  • 8
    • 79952108690 scopus 로고    scopus 로고
    • The endless race between Trypanosoma cruzi and host immunity: Lessons for and beyond Chagas disease
    • Junqueira C, Caetano B, Bartholomeu DC et al. The endless race between Trypanosoma cruzi and host immunity: lessons for and beyond Chagas disease. Expert Rev. Mol. Med. 12, e29 (2010).
    • (2010) Expert Rev. Mol. Med. , vol.12
    • Junqueira, C.1    Caetano, B.2    Bartholomeu, D.C.3
  • 9
    • 0037213017 scopus 로고    scopus 로고
    • Etiology of Chagas disease myocarditis: Autoimmunity parasite persistence or both
    • Girones N, Fresno M. Etiology of Chagas disease myocarditis: Autoimmunity, parasite persistence, or both? Trends Parasitol. 19(1), 19-22 (2003).
    • (2003) Trends Parasitol. , vol.19 , Issue.1 , pp. 19-22
    • Girones, N.1    Fresno, M.2
  • 11
    • 33748308787 scopus 로고    scopus 로고
    • Toll-like receptors and innate immunity
    • Uematsu S, Akira S. Toll-like receptors and innate immunity. J. Mol. Med. 84(9), 712-725 (2006).
    • (2006) J. Mol. Med. , vol.84 , Issue.9 , pp. 712-725
    • Uematsu, S.1    Akira, S.2
  • 12
    • 33847183077 scopus 로고    scopus 로고
    • Cooperation of Toll-like receptor signals in innate immune defence
    • Trinchieri G, Sher A. Cooperation of Toll-like receptor signals in innate immune defence. Nat. Rev. Immunol. 7(3), 179-190 (2007).
    • (2007) Nat. Rev. Immunol. , vol.7 , Issue.3 , pp. 179-190
    • Trinchieri, G.1    Sher, A.2
  • 13
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
    • Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat. Immunol. 11(5), 373-384 (2010).
    • (2010) Nat. Immunol. , vol.11 , Issue.5 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 14
    • 4143132253 scopus 로고    scopus 로고
    • Trypanosoma cruzi and its components as exogenous mediators of inflammation recognized through Toll-like receptors
    • Campos MA, Gazzinelli RT. Trypanosoma cruzi and its components as exogenous mediators of inflammation recognized through Toll-like receptors. Mediators Inflamm. 13(3), 139-143 (2004).
    • (2004) Mediators Inflamm. , vol.13 , Issue.3 , pp. 139-143
    • Campos, M.A.1    Gazzinelli, R.T.2
  • 15
    • 34548021449 scopus 로고    scopus 로고
    • Immune system recognition of Trypanosoma cruzi
    • Tarleton RL. Immune system recognition of Trypanosoma cruzi. Curr. Opin. Immunol. 19(4), 430-434 (2007).
    • (2007) Curr. Opin. Immunol. , vol.19 , Issue.4 , pp. 430-434
    • Tarleton, R.L.1
  • 16
    • 77953024151 scopus 로고    scopus 로고
    • The innate immune response to Trypanosoma cruzi infection
    • Kayama H, Takeda K. The innate immune response to Trypanosoma cruzi infection. Microbes Infect. 12(7), 511-517 (2010).
    • (2010) Microbes Infect. , vol.12 , Issue.7 , pp. 511-517
    • Kayama, H.1    Takeda, K.2
  • 17
    • 78649776036 scopus 로고    scopus 로고
    • Importance of TLR2 on hepatic immune and non-immune cells to attenuate the strong inflammatory liver response during Trypanosoma cruzi acute infection
    • Carrera-Silva EA, Guinazu N, Pellegrini A et al. Importance of TLR2 on hepatic immune and non-immune cells to attenuate the strong inflammatory liver response during Trypanosoma cruzi acute infection. PLoS Negl. Trop. Dis. 4(11), e863 (2010).
    • (2010) PLoS Negl. Trop. Dis. , vol.4 , Issue.11
    • Carrera-Silva, E.A.1    Guinazu, N.2    Pellegrini, A.3
  • 19
    • 30744462300 scopus 로고    scopus 로고
    • Regulation of lung injury and repair by Toll-like receptors and hyaluronan
    • Jiang D, Liang J, Fan J et al. Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat. Med. 11(11), 1173-1179 (2005).
    • (2005) Nat. Med. , vol.11 , Issue.11 , pp. 1173-1179
    • Jiang, D.1    Liang, J.2    Fan, J.3
  • 20
    • 33846035724 scopus 로고    scopus 로고
    • Mammalian toll-like receptors: From endogenous ligands to tissue regeneration
    • Zhang Z, Schluesener HJ. Mammalian toll-like receptors: from endogenous ligands to tissue regeneration. Cell. Mol. Life Sci. 63(24), 2901-2907 (2006).
    • (2006) Cell. Mol. Life Sci. , vol.63 , Issue.24 , pp. 2901-2907
    • Zhang, Z.1    Schluesener, H.J.2
  • 21
    • 1142309739 scopus 로고    scopus 로고
    • Modulating Toll-like receptor mediated signaling by 1 3-beta-d-glucan rapidly induces cardioprotection
    • Li C, Ha T, Kelley J et al. Modulating Toll-like receptor mediated signaling by (1?3)-beta-d-glucan rapidly induces cardioprotection. Cardiovasc. Res. 61(3), 538-547 (2004).
    • (2004) Cardiovasc. Res. , vol.61 , Issue.3 , pp. 538-547
    • Li, C.1    Ha, T.2    Kelley, J.3
  • 22
    • 34249787873 scopus 로고    scopus 로고
    • Protection against myocardial ischemia/reperfusion injury in TLR4-deficient mice is mediated through a phosphoinositide 3-kinase-dependent mechanism
    • Hua F, Ha T, Ma J et al. Protection against myocardial ischemia/reperfusion injury in TLR4-deficient mice is mediated through a phosphoinositide 3-kinase-dependent mechanism. J. Immunol. 178(11), 7317-7324 (2007).
    • (2007) J. Immunol. , vol.178 , Issue.11 , pp. 7317-7324
    • Hua, F.1    Ha, T.2    Ma, J.3
  • 23
    • 0035399862 scopus 로고    scopus 로고
    • Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite
    • Campos MA, Almeida IC, Takeuchi O et al. Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite. J. Immunol. 167(1), 416-423 (2001).
    • (2001) J. Immunol. , vol.167 , Issue.1 , pp. 416-423
    • Campos, M.A.1    Almeida, I.C.2    Takeuchi, O.3
  • 24
    • 47649098203 scopus 로고    scopus 로고
    • Rab5 activation by Toll-like receptor 2 is required for Trypanosoma cruzi internalization and replication in macrophages
    • Maganto-Garcia E, Punzon C, Terhorst C, Fresno M. Rab5 activation by Toll-like receptor 2 is required for Trypanosoma cruzi internalization and replication in macrophages. Traffic 9(8), 1299-1315 (2008).
    • (2008) Traffic , vol.9 , Issue.8 , pp. 1299-1315
    • Maganto-Garcia, E.1    Punzon, C.2    Terhorst, C.3    Fresno, M.4
  • 25
    • 6344241296 scopus 로고    scopus 로고
    • Expression of functional TLR4 confers proinflammatory responsiveness to Trypanosoma cruzi glycoinositolphospholipids and higher resistance to infection with T. cruzi
    • Oliveira AC, Peixoto JR, de Arruda LB et al. Expression of functional TLR4 confers proinflammatory responsiveness to Trypanosoma cruzi glycoinositolphospholipids and higher resistance to infection with T. cruzi. J. Immunol. 173(9), 5688-5696 (2004).
    • (2004) J. Immunol. , vol.173 , Issue.9 , pp. 5688-5696
    • Oliveira, A.C.1    Peixoto, J.R.2    De Arruda, L.B.3
  • 26
    • 33845204804 scopus 로고    scopus 로고
    • Protozoan encounters with Toll-like receptor signalling pathways: I mplications for host parasitism
    • Gazzinelli RT, Denkers EY. Protozoan encounters with Toll-like receptor signalling pathways: I mplications for host parasitism. Nat. Rev. Immunol. 6(12), 895-906 (2006).
    • (2006) Nat. Rev. Immunol. , vol.6 , Issue.12 , pp. 895-906
    • Gazzinelli, R.T.1    Denkers, E.Y.2
  • 27
    • 0037097776 scopus 로고    scopus 로고
    • The Trypanosoma cruzi Tc52-released protein induces human dendritic cell maturation signals via Toll-like receptor 2, and confers protection against lethal infection
    • Ouaissi A, Guilvard E, Delneste Y et al. The Trypanosoma cruzi Tc52-released protein induces human dendritic cell maturation, signals via Toll-like receptor 2, and confers protection against lethal infection. J. Immunol. 168(12), 6366-6374 (2002).
    • (2002) J. Immunol. , vol.168 , Issue.12 , pp. 6366-6374
    • Ouaissi, A.1    Guilvard, E.2    Delneste, Y.3
  • 28
    • 0036587576 scopus 로고    scopus 로고
    • Glycosylphosphatidylinositol-anchored mucin-like glycoproteins isolated from Trypanosoma cruzi trypomastigotes induce in vivo leukocyte recruitment dependent on MCP-1 production by IFN-gamma-primed-macrophages
    • Coelho PS, Klein A, Talvani A, Coutinho SF et al. Glycosylphosphatidylinositol-anchored mucin-like glycoproteins isolated from Trypanosoma cruzi trypomastigotes induce in vivo leukocyte recruitment dependent on MCP-1 production by IFN-gamma-primed-macrophages. J. Leukoc Biol. 71(5), 837-844 (2002).
    • (2002) J. Leukoc Biol. , vol.71 , Issue.5 , pp. 837-844
    • Coelho, P.S.1    Klein, A.2    Talvani, A.3    Coutinho, S.F.4
  • 29
    • 46949093807 scopus 로고    scopus 로고
    • TLR2 TLR4 and TLR9 are differentially modulated in liver lethally injured from BALB/c and C57BL/6 mice during Trypanosoma cruzi acute infection
    • Carrera-Silva EA, Carolina CR, Natalia G, Pilar AM, Andrea P, Gea S. TLR2, TLR4 and TLR9 are differentially modulated in liver lethally injured from BALB/c and C57BL/6 mice during Trypanosoma cruzi acute infection. Mol. Immunol. 45(13), 3580-3588 (2008).
    • (2008) Mol. Immunol. , vol.45 , Issue.13 , pp. 3580-3588
    • Carrera-Silva, E.A.1    Carolina, C.R.2    Natalia, G.3    Pilar, A.M.4    Andrea, P.5    Gea, S.6
  • 30
    • 0035082873 scopus 로고    scopus 로고
    • DNA from protozoan parasites Babesia bovis Trypanosoma cruzi and T brucei is mitogenic for B lymphocytes and stimulates macrophage expression of interleukin-12 tumor necrosis factor alpha, and nitric oxide
    • Shoda LK, Kegerreis KA, Suarez CE et al. DNA from protozoan parasites Babesia bovis, Trypanosoma cruzi, and T. brucei is mitogenic for B lymphocytes and stimulates macrophage expression of interleukin-12, tumor necrosis factor alpha, and nitric oxide. Infect. Immun. 69(4), 2162-2171 (2001).
    • (2001) Infect. Immun. , vol.69 , Issue.4 , pp. 2162-2171
    • Shoda, L.K.1    Kegerreis, K.A.2    Suarez, C.E.3
  • 31
    • 1642525756 scopus 로고    scopus 로고
    • Impaired production of proinflammatory cytokines and host resistance to acute infection with Trypanosoma cruzi in mice lacking functional myeloid differentiation factor 88
    • Campos MA, Closel M, Valente EP et al. Impaired production of proinflammatory cytokines and host resistance to acute infection with Trypanosoma cruzi in mice lacking functional myeloid differentiation factor 88. J. Immunol. 172(3), 1711-1718 (2004).
    • (2004) J. Immunol. , vol.172 , Issue.3 , pp. 1711-1718
    • Campos, M.A.1    Closel, M.2    Valente, E.P.3
  • 32
    • 33748477504 scopus 로고    scopus 로고
    • Cutting edge: TLR9 and TLR2 signaling together account for MyD88-dependent control of parasitemia in Trypanosoma cruzi infection
    • Bafica A, Santiago HC, Goldszmid R, Ropert C, Gazzinelli RT, Sher A. Cutting edge: TLR9 and TLR2 signaling together account for MyD88-dependent control of parasitemia in Trypanosoma cruzi infection. J. Immunol. 177(6), 3515-3519 (2006).
    • (2006) J. Immunol. , vol.177 , Issue.6 , pp. 3515-3519
    • Bafica, A.1    Santiago, H.C.2    Goldszmid, R.3    Ropert, C.4    Gazzinelli, R.T.5    Sher, A.6
  • 33
    • 80051937446 scopus 로고    scopus 로고
    • Requirement of UNC93B1 reveals a critical role for TLR7 in host resistance to primary infection with Trypanosoma cruzi
    • Caetano BC, Carmo BB, Melo MB et al. Requirement of UNC93B1 reveals a critical role for TLR7 in host resistance to primary infection with Trypanosoma cruzi. J. Immunol. 187(4), 1903-1911 (2011).
    • (2011) J. Immunol. , vol.187 , Issue.4 , pp. 1903-1911
    • Caetano, B.C.1    Carmo, B.B.2    Melo, M.B.3
  • 35
    • 77954049583 scopus 로고    scopus 로고
    • 8+ T cell responses against Trypanosoma cruzi in Tlr4-, Tlr2-, Tlr9-or Myd88-deficient mice
    • 8+ T cell responses against Trypanosoma cruzi in Tlr4-, Tlr2-, Tlr9-or Myd88-deficient mice. PLoS Pathog. 6(4), e1000870 (2010).
    • (2010) PLoS Pathog. , vol.6 , Issue.4
    • Oliveira, A.C.1    De Alencar, B.C.2    Tzelepis, F.3
  • 36
    • 47149105036 scopus 로고    scopus 로고
    • Toll-like receptors and adaptor molecules in liver disease: Update
    • Seki E, Brenner DA. Toll-like receptors and adaptor molecules in liver disease: update. Hepatology 48(1), 322-335 (2008).
    • (2008) Hepatology , vol.48 , Issue.1 , pp. 322-335
    • Seki, E.1    Brenner, D.A.2
  • 37
    • 39549097751 scopus 로고    scopus 로고
    • Liver: An organ with predominant innate immunity
    • Gao B, Jeong WI, Tian Z. Liver: An organ with predominant innate immunity. Hepatology 47(2), 729-736 (2008).
    • (2008) Hepatology , vol.47 , Issue.2 , pp. 729-736
    • Gao, B.1    Jeong, W.I.2    Tian, Z.3
  • 38
    • 67650750880 scopus 로고    scopus 로고
    • The liver as a lymphoid organ
    • Crispe IN. The liver as a lymphoid organ. Annu. Rev. Immunol. 27, 147-163 (2009).
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 147-163
    • Crispe, I.N.1
  • 39
    • 34247330085 scopus 로고    scopus 로고
    • NK cell activation in visceral leishmaniasis requires TLR9 myeloid DCs and IL-12 but is independent of plasmacytoid DCs
    • Schleicher U, Liese J, Knippertz I et al. NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs. J. Exp Med. 204(4), 893-906 (2007).
    • (2007) J. Exp Med. , vol.204 , Issue.4 , pp. 893-906
    • Schleicher, U.1    Liese, J.2    Knippertz, I.3
  • 40
    • 0034642343 scopus 로고    scopus 로고
    • Trypanosoma cruzi-infected cardiomyocytes produce chemokines and cytokines that trigger potent nitric oxide-dependent trypanocidal activity
    • Machado FS, Martins GA, Aliberti JC, Mestriner FL, Cunha FQ, Silva JS. Trypanosoma cruzi-infected cardiomyocytes produce chemokines and cytokines that trigger potent nitric oxide-dependent trypanocidal activity. Circulation 102(24), 3003-3008 (2000).
    • (2000) Circulation , vol.102 , Issue.24 , pp. 3003-3008
    • Machado, F.S.1    Martins, G.A.2    Aliberti, J.C.3    Mestriner, F.L.4    Cunha, F.Q.5    Silva, J.S.6
  • 41
    • 79952693649 scopus 로고    scopus 로고
    • Modulation of inflammatory response and parasitism by 15-deoxy-delta 12 14 prostaglandin J 2 in Trypanosoma cruzi-infected cardiomyocytes
    • Hovsepian E, Mirkin GA, Penas F, Manzano A, Bartrons R, Goren NB. Modulation of inflammatory response and parasitism by 15-deoxy-delta(12,14) prostaglandin J(2) in Trypanosoma cruzi-infected cardiomyocytes. Int. J. Parasitol. 41(5), 553-562 (2011).
    • (2011) Int. J. Parasitol. , vol.41 , Issue.5 , pp. 553-562
    • Hovsepian, E.1    Mirkin, G.A.2    Penas, F.3    Manzano, A.4    Bartrons, R.5    Goren, N.B.6
  • 42
    • 79955611821 scopus 로고    scopus 로고
    • Trypanosoma cruzi infection induces a global host cell response in cardiomyocytes
    • Manque PA, Probst CM, Pereira MC et al. Trypanosoma cruzi infection induces a global host cell response in cardiomyocytes. Infect. Immun. 79(5), 1855-1862 (2011).
    • (2011) Infect. Immun. , vol.79 , Issue.5 , pp. 1855-1862
    • Manque, P.A.1    Probst, C.M.2    Pereira, M.C.3
  • 44
    • 0742270761 scopus 로고    scopus 로고
    • Cruzipain a major Trypanosoma cruzi antigen promotes arginase-2 expression and survival of neonatal mouse cardiomyocytes
    • Aoki MP, Guinazu NL, Pellegrini AV, Gotoh T, Masih DT, Gea S. Cruzipain, a major Trypanosoma cruzi antigen, promotes arginase-2 expression and survival of neonatal mouse cardiomyocytes. Am J. Physiol. Cell Physiol. 286(2), C206-C212 (2004).
    • (2004) Am J. Physiol. Cell Physiol. , vol.286 , Issue.2
    • Aoki, M.P.1    Guinazu, N.L.2    Pellegrini, A.V.3    Gotoh, T.4    Masih, D.T.5    Gea, S.6
  • 45
    • 33746562888 scopus 로고    scopus 로고
    • Different signaling pathways are involved in cardiomyocyte survival induced by a Trypanosoma cruzi glycoprotein
    • Aoki Mdel P, Cano RC, Pellegrini AV et al. Different signaling pathways are involved in cardiomyocyte survival induced by a Trypanosoma cruzi glycoprotein. Microbes. Infect. 8(7), 1723-1731 (2006).
    • (2006) Microbes. Infect. , vol.8 , Issue.7 , pp. 1723-1731
    • Aoki Mdel, P.1    Cano, R.C.2    Pellegrini, A.V.3
  • 46
    • 0035298111 scopus 로고    scopus 로고
    • Trypanosoma cruzi: phosphatidylinositol 3-kinase and protein kinase B activation is associated with parasite invasion
    • Wilkowsky SE, Barbieri MA, Stahl P, Isola EL. Trypanosoma cruzi: phosphatidylinositol 3-kinase and protein kinase B activation is associated with parasite invasion. Exp. Cell. Res. 264(2), 211-218 (2001).
    • (2001) Exp. Cell. Res. , vol.264 , Issue.2 , pp. 211-218
    • Wilkowsky, S.E.1    Barbieri, M.A.2    Stahl, P.3    Isola, E.L.4
  • 47
    • 0037406841 scopus 로고    scopus 로고
    • Activation of transcription factors AP-1 and NF-kappa B in murine Chagasic myocarditis
    • Huang H, Petkova SB, Cohen AW et al. Activation of transcription factors AP-1 and NF-kappa B in murine Chagasic myocarditis. Infect. Immun. 71(5), 2859-2867 (2003).
    • (2003) Infect. Immun. , vol.71 , Issue.5 , pp. 2859-2867
    • Huang, H.1    Petkova, S.B.2    Cohen, A.W.3
  • 48
    • 84863434983 scopus 로고    scopus 로고
    • Toll-like receptor-2 and interleukin-6 mediate cardiomyocyte protection from apoptosis during Trypanosoma cruzi murine infection
    • doi:10.1007/s00430-rfsti 011-0216-z Epub ahead of pint).
    • Ponce NE, Cano RC, Carrera-Silva EA, Lima AP, Gea S, Aoki MP. Toll-like receptor-2 and interleukin-6 mediate cardiomyocyte protection from apoptosis during Trypanosoma cruzi murine infection. Med. Microbiol. Immunol. doi:10.1007/s00430-011-0216-z (2011) (Epub ahead of pint).
    • (2011) Med. Microbiol. Immunol.
    • Ponce, N.E.1    Cano, R.C.2    Carrera-Silva, E.A.3    Lima, A.P.4    Gea, S.5    Aoki, M.P.6
  • 49
    • 25444434368 scopus 로고    scopus 로고
    • Toll-like receptor 2 regulates interleukin-1beta-dependent cardiomyocyte hypertrophy triggered by Trypanosoma cruzi
    • Petersen CA, Krumholz KA, Burleigh BA. Toll-like receptor 2 regulates interleukin-1beta-dependent cardiomyocyte hypertrophy triggered by Trypanosoma cruzi. Infect. Immun. 73(10), 6974-6980 (2005).
    • (2005) Infect. Immun. , vol.73 , Issue.10 , pp. 6974-6980
    • Petersen, C.A.1    Krumholz, K.A.2    Burleigh, B.A.3
  • 50
    • 31444456321 scopus 로고    scopus 로고
    • Parasite cysteine proteinase interactions with alpha 2-macroglobulin or kininogens: differential pathways modulating inflammation and innate immunity in infection by pathogenic trypanosomatids
    • Scharfstein J. Parasite cysteine proteinase interactions with alpha 2-macroglobulin or kininogens: differential pathways modulating inflammation and innate immunity in infection by pathogenic trypanosomatids. Immunobiology 211(1-2), 117-125 (2006).
    • (2006) Immunobiology , vol.211 , Issue.1-2 , pp. 117-125
    • Scharfstein, J.1
  • 51
    • 0037514586 scopus 로고    scopus 로고
    • Cutting edge: Bradykinin induces IL-12 production by dendritic cells: A danger signal that drives Th1 polarization
    • Aliberti J, Viola JP, Vieira-de-Abreu A, Bozza PT, Sher A, Scharfstein J. Cutting edge: bradykinin induces IL-12 production by dendritic cells: A danger signal that drives Th1 polarization. J. Immunol. 170(11), 5349-5353 (2003).
    • (2003) J. Immunol. , vol.170 , Issue.11 , pp. 5349-5353
    • Aliberti, J.1    Viola, J.P.2    Vieira-De-Abreu, A.3    Bozza, P.T.4    Sher, A.5    Scharfstein, J.6
  • 52
    • 37349081546 scopus 로고    scopus 로고
    • Bradykinin B2 receptors of dendritic cells acting as sensors of kinins proteolytically released by Trypanosoma cruzi are critical for the development of protective type-1 responses
    • Monteiro AC, Schmitz V, Morrot A et al. Bradykinin B2 receptors of dendritic cells, acting as sensors of kinins proteolytically released by Trypanosoma cruzi, are critical for the development of protective type-1 responses. PLoS Pathog. 3(11), 185 (2007).
    • (2007) PLoS Pathog. , vol.3 , Issue.11 , pp. 185
    • Monteiro, A.C.1    Schmitz, V.2    Morrot, A.3
  • 53
    • 67149135208 scopus 로고    scopus 로고
    • Proteolytic generation of kinins in tissues infected by Trypanosoma cruzi depends on CXC chemokine secretion by macrophages activated via Toll-like 2 receptors
    • Schmitz V, Svensjo E, Serra RR, Teixeira MM, Scharfstein J. Proteolytic generation of kinins in tissues infected by Trypanosoma cruzi depends on CXC chemokine secretion by macrophages activated via Toll-like 2 receptors. J. Leukoc. Biol. 85(6), 1005-1014 (2009).
    • (2009) J. Leukoc. Biol. , vol.85 , Issue.6 , pp. 1005-1014
    • Schmitz, V.1    Svensjo, E.2    Serra, R.R.3    Teixeira, M.M.4    Scharfstein, J.5
  • 54
    • 77950343791 scopus 로고    scopus 로고
    • Pattern recognition receptors and inflammation
    • Takeuchi O, Akira S. Pattern recognition receptors and inflammation. Cell 140(6), 805-820 (2010).
    • (2010) Cell , vol.140 , Issue.6 , pp. 805-820
    • Takeuchi, O.1    Akira, S.2
  • 55
    • 21244496869 scopus 로고    scopus 로고
    • The adipocyte as an important target cell for Trypanosoma cruzi infection
    • Combs TP, Nagajyothi, Mukherjee S et al. The adipocyte as an important target cell for Trypanosoma cruzi infection. J. Biol Chem 280(25), 24085-24094 (2005).
    • (2005) J. Biol. Chem. , vol.280 , Issue.25 , pp. 24085-24094
    • Combs, T.P.1    Nagajyothi Mukherjee, S.2
  • 56
    • 50649088581 scopus 로고    scopus 로고
    • Trypanosoma cruzi infection of cultured adipocytes results in an inflammatory phenotype
    • Nagajyothi F, Desruisseaux MS, Thiruvur N et al. Trypanosoma cruzi infection of cultured adipocytes results in an inflammatory phenotype. Obesity (Silver Spring) 16(9), 1992-1997 (2008).
    • (2008) Obesity Silver Spring , vol.16 , Issue.9 , pp. 1992-1997
    • Nagajyothi, F.1    Desruisseaux, M.S.2    Thiruvur, N.3
  • 57
    • 0032102990 scopus 로고    scopus 로고
    • 4+ T cells correlates with Th1/Th2 phenotype
    • 4+ T cells correlates with Th1/Th2 phenotype. J. Immunol. 160(11), 5347-5354 (1998).
    • (1998) J. Immunol. , vol.160 , Issue.11 , pp. 5347-5354
    • Munder, M.1    Eichmann, K.2    Modolell, M.3
  • 58
    • 0036839143 scopus 로고    scopus 로고
    • Macrophage polarization: Tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    • Mantovani A, Sozzani S, Locati M, Allavena P, Sica A. Macrophage polarization: Tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 23(11), 549-555 (2002).
    • (2002) Trends Immunol. , vol.23 , Issue.11 , pp. 549-555
    • Mantovani, A.1    Sozzani, S.2    Locati, M.3    Allavena, P.4    Sica, A.5
  • 59
    • 0037310024 scopus 로고    scopus 로고
    • The many faces of macrophage activation
    • Mosser DM. The many faces of macrophage activation. J. Leukoc. Biol. 73(2), 209-212 (2003).
    • (2003) J. Leukoc. Biol. , vol.73 , Issue.2 , pp. 209-212
    • Mosser, D.M.1
  • 60
    • 0036826843 scopus 로고    scopus 로고
    • Alternative activation and increase of Trypanosoma cruzi survival in murine macrophages stimulated by cruzipain a parasite antigen
    • Stempin C, Giordanengo L, Gea S, Cerban F. Alternative activation and increase of Trypanosoma cruzi survival in murine macrophages stimulated by cruzipain, a parasite antigen. J. Leukoc. Biol. 72(4), 727-734 (2002).
    • (2002) J. Leukoc. Biol. , vol.72 , Issue.4 , pp. 727-734
    • Stempin, C.1    Giordanengo, L.2    Gea, S.3    Cerban, F.4
  • 61
    • 1642554787 scopus 로고    scopus 로고
    • Arginase induction promotes Trypanosoma cruzi intracellular replication in Cruzipain-treated J774 cells through the activation of multiple signaling pathways
    • Stempin CC, Tanos TB, Coso OA, Cerban FM. Arginase induction promotes Trypanosoma cruzi intracellular replication in Cruzipain-treated J774 cells through the activation of multiple signaling pathways. Eur J. Immunol. 34(1), 200-209 (2004).
    • (2004) Eur. J. Immunol. , vol.34 , Issue.1 , pp. 200-209
    • Stempin, C.C.1    Tanos, T.B.2    Coso, O.A.3    Cerban, F.M.4
  • 62
    • 0036232437 scopus 로고    scopus 로고
    • Cruzipain a major trypanosoma cruzi antigen conditions the host immune response in favor of parasite
    • Giordanengo L, Guinazu N, Stempin C, Fretes R, Cerban F, Gea S. Cruzipain, a major Trypanosoma cruzi antigen, conditions the host immune response in favor of parasite. Eur J. Immunol. 32(4), 1003-1011 (2002).
    • (2002) Eur J. Immunol. , vol.32 , Issue.4 , pp. 1003-1011
    • Giordanengo, L.1    Guinazu, N.2    Stempin, C.3    Fretes, R.4    Cerban, F.5    Gea, S.6
  • 63
    • 34547115710 scopus 로고    scopus 로고
    • Immunisation with a major trypanosoma cruzi antigen promotes pro-inflammatory cytokines nitric oxide production and increases TLR2 expression
    • Guinazu N, Pellegrini A, Carrera-Silva EA et al. Immunisation with a major Trypanosoma cruzi antigen promotes pro-inflammatory cytokines, nitric oxide production and increases TLR2 expression. Int. J. Parasitol. 37(11), 1243-1254 (2007).
    • (2007) Int. J. Parasitol. , vol.37 , Issue.11 , pp. 1243-1254
    • Guinazu, N.1    Pellegrini, A.2    Carrera-Silva, E.A.3
  • 64
    • 0032783138 scopus 로고    scopus 로고
    • Predominance of CD4 Th1 and CD8 Tc1 cells revealed by characterization of the cellular immune response generated by immunization with a DNA vaccine containing a Trypanosoma cruzi gene
    • Rodrigues MM, Ribeirao M, Pereira-Chioccola V, Renia L, Costa F. Predominance of CD4 Th1 and CD8 Tc1 cells revealed by characterization of the cellular immune response generated by immunization with a DNA vaccine containing a Trypanosoma cruzi gene. Infect. Immun. 67(8), 3855-3863 (1999).
    • (1999) Infect. Immun. , vol.67 , Issue.8 , pp. 3855-3863
    • Rodrigues, M.M.1    Ribeirao, M.2    Pereira-Chioccola, V.3    Renia, L.4    Costa, F.5
  • 65
    • 0034872007 scopus 로고    scopus 로고
    • 8+ T-cell epitopes are important for efficient protective immunity induced by DNA vaccination with a Trypanosoma cruzi gene
    • 8+ T-cell epitopes are important for efficient protective immunity induced by DNA vaccination with a Trypanosoma cruzi gene. Infect. Immun. 69(9), 5477-5486 (2001).
    • (2001) Infect. Immun. , vol.69 , Issue.9 , pp. 5477-5486
    • Fujimura, A.E.1    Kinoshita, S.S.2    Pereira-Chioccola, V.L.3    Rodrigues, M.M.4
  • 66
    • 0030054867 scopus 로고    scopus 로고
    • Assembly of the human neutrophil NADPH oxidase involves binding of p67phox and flavocytochrome b to a common functional domain in p47phox
    • De Leo FR, Ulman KV, Davis AR, Jutila KL, Quinn MT. Assembly of the human neutrophil NADPH oxidase involves binding of p67phox and flavocytochrome b to a common functional domain in p47phox. J. Biol. Chem. 271(29), 17013-17020 (1996).
    • (1996) J. Biol. Chem. , vol.271 , Issue.29 , pp. 17013-17020
    • De Leo, F.R.1    Ulman, K.V.2    Davis, A.R.3    Jutila, K.L.4    Quinn, M.T.5
  • 67
    • 77957749794 scopus 로고    scopus 로고
    • Induction of NADPH oxidase activity and reactive oxygen species production by a single Trypanosoma cruzi antigen
    • Guinazu N, Carrera-Silva EA, Becerra MC, Pellegrini A, Albesa I, Gea S. Induction of NADPH oxidase activity and reactive oxygen species production by a single Trypanosoma cruzi antigen. Int. J. Parasitol. 40(13), 1531-1538 (2010).
    • (2010) Int. J. Parasitol. , vol.40 , Issue.13 , pp. 1531-1538
    • Guinazu, N.1    Carrera-Silva, E.A.2    Becerra, M.C.3    Pellegrini, A.4    Albesa, I.5    Gea, S.6
  • 68
    • 0020636022 scopus 로고
    • Role of polymorphonuclear cells in Chagas disease I uptake and mechanisms of destruction of intracellular amastigote forms of Trypanosoma cruzi by human neutrophils
    • Villalta F, Kierszenbaum F. Role of polymorphonuclear cells in Chagas' disease. I. Uptake and mechanisms of destruction of intracellular (amastigote) forms of Trypanosoma cruzi by human neutrophils. J. Immunol. 131(3), 504-510 (1983).
    • (1983) J. Immunol. , vol.131 , Issue.3 , pp. 504-510
    • Villalta, F.1    Kierszenbaum, F.2
  • 69
    • 0030929847 scopus 로고    scopus 로고
    • Release of reactive oxygen species by phagocytic cells in response to live parasites in mice infected with Trypanosoma cruzi
    • Cardoni RL, Antunez MI, Morales C, Nantes IR. Release of reactive oxygen species by phagocytic cells in response to live parasites in mice infected with Trypanosoma cruzi. Am. J. Trop. Med. Hyg. 56(3), 329-334 (1997).
    • (1997) Am. J. Trop. Med. Hyg. , vol.56 , Issue.3 , pp. 329-334
    • Cardoni, R.L.1    Antunez, M.I.2    Morales, C.3    Nantes, I.R.4
  • 70
    • 0026522956 scopus 로고
    • Induction of macrophage activation and opsonizing antibodies by Trypanosoma cruzi subpopulations
    • Celentano AM, Gonzalez Cappa SM. Induction of macrophage activation and opsonizing antibodies by Trypanosoma cruzi subpopulations. Parasite Immunol. 14(2), 155-167 (1992).
    • (1992) Parasite Immunol. , vol.14 , Issue.2 , pp. 155-167
    • Celentano, A.M.1    Gonzalez Cappa, S.M.2
  • 71
    • 0141853754 scopus 로고    scopus 로고
    • Production of hydrogen peroxide by peripheral blood monocytes and specific macrophages during experimental infection with Trypanosoma cruzi in vivo
    • Melo RC, Fabrino DL, D'Avila H, Teixeira HC, Ferreira AP. Production of hydrogen peroxide by peripheral blood monocytes and specific macrophages during experimental infection with Trypanosoma cruzi in vivo. Cell. Biol. Int. 27(10), 853-861 (2003).
    • (2003) Cell. Biol. Int. , vol.27 , Issue.10 , pp. 853-861
    • Melo, R.C.1    Fabrino, D.L.2    D'Avila, H.3    Teixeira, H.C.4    Ferreira, A.P.5
  • 72
    • 27144477318 scopus 로고    scopus 로고
    • Cutting edge: MyD88 controls phagocyte NADPH oxidase function and killing of gram-negative bacteria
    • Laroux FS, Romero X, Wetzler L, Engel P, Terhorst C. Cutting edge: MyD88 controls phagocyte NADPH oxidase function and killing of gram-negative bacteria. J. Immunol. 175(9), 5596-5600 (2005).
    • (2005) J. Immunol. , vol.175 , Issue.9 , pp. 5596-5600
    • Laroux, F.S.1    Romero, X.2    Wetzler, L.3    Engel, P.4    Terhorst, C.5
  • 73
    • 79955532516 scopus 로고    scopus 로고
    • TLR signalling augments macrophage bactericidal activity through mitochondrial ROS
    • West AP, Brodsky IE, Rahner C et al. TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature 472(7344), 476-480 (2011).
    • (2011) Nature , vol.472 , Issue.7344 , pp. 476-480
    • West, A.P.1    Brodsky, I.E.2    Rahner, C.3
  • 74
    • 79953183972 scopus 로고    scopus 로고
    • Intraphagosomal peroxynitrite as a macrophage-derived cytotoxin against internalized Trypanosoma cruzi: Consequences for oxidative killing and role of microbial peroxiredoxins in infectivity
    • Alvarez MN, Peluffo G, Piacenza L, Radi R. Intraphagosomal peroxynitrite as a macrophage-derived cytotoxin against internalized Trypanosoma cruzi: Consequences for oxidative killing and role of microbial peroxiredoxins in infectivity. J. Biol Chem 286(8), 6627-6640 (2011).
    • (2011) J. Biol. Chem. , vol.286 , Issue.8 , pp. 6627-6640
    • Alvarez, M.N.1    Peluffo, G.2    Piacenza, L.3    Radi, R.4
  • 75
    • 0031002421 scopus 로고    scopus 로고
    • Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages
    • USA
    • Xia Y, Zweier JL. Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages. Proc. Natl Acad. Sci. USA 94(13), 6954-6958 (1997).
    • (1997) Proc. Natl Acad. Sci. , vol.94 , Issue.13 , pp. 6954-6958
    • Xia, Y.1    Zweier, J.L.2
  • 76
    • 1642536454 scopus 로고    scopus 로고
    • 8+ T cell response by immature myeloid cells in cancer is mediated by reactive oxygen species
    • 8+ T cell response by immature myeloid cells in cancer is mediated by reactive oxygen species. J. Immunol. 172(2), 989-999 (2004).
    • (2004) J. Immunol. , vol.172 , Issue.2 , pp. 989-999
    • Kusmartsev, S.1    Nefedova, Y.2    Yoder, D.3    Gabrilovich, D.I.4
  • 77
    • 31044453296 scopus 로고    scopus 로고
    • An overview of chagasic cardiomyopathy: Pathogenic importance of oxidative stress
    • Zacks MA, Wen JJ, Vyatkina G, Bhatia V, Garg N. An overview of chagasic cardiomyopathy: pathogenic importance of oxidative stress. An. Acad. Bras. Cienc. 77(4), 695-715 (2005).
    • (2005) An. Acad. Bras. Cienc. , vol.77 , Issue.4 , pp. 695-715
    • Zacks, M.A.1    Wen, J.J.2    Vyatkina, G.3    Bhatia, V.4    Garg, N.5
  • 78
    • 0034254417 scopus 로고    scopus 로고
    • Increased susceptibility of Stat4-deficient and enhanced resistance in Stat6-deficient mice to infection with Trypanosoma cruzi
    • Tarleton RL, Grusby MJ, Zhang L. Increased susceptibility of Stat4-deficient and enhanced resistance in Stat6-deficient mice to infection with Trypanosoma cruzi. J. Immunol. 165(3), 1520-1525 (2000).
    • (2000) J. Immunol. , vol.165 , Issue.3 , pp. 1520-1525
    • Tarleton, R.L.1    Grusby, M.J.2    Zhang, L.3
  • 79
    • 0034884975 scopus 로고    scopus 로고
    • Modulation of chagasic cardiomyopathy by interleukin-4: Dissociation between inflammation and tissue parasitism
    • Soares MB, Silva-Mota KN, Lima RS et al. Modulation of chagasic cardiomyopathy by interleukin-4: dissociation between inflammation and tissue parasitism. Am. J. Pathol. 159(2), 703-709 (2001).
    • (2001) Am. J. Pathol. , vol.159 , Issue.2 , pp. 703-709
    • Soares, M.B.1    Silva-Mota, K.N.2    Lima, R.S.3
  • 80
    • 0025501055 scopus 로고
    • Functional and antigenic properties of the major cysteine proteinase GP57/51 of Trypanosoma cruzi
    • Meirelles MN, Juliano L, Carmona E et al. Functional and antigenic properties of the major cysteine proteinase (GP57/51) of Trypanosoma cruzi. Mem. Inst. Oswaldo Cruz 85(4), 533-538 (1990).
    • (1990) Mem. Inst. Oswaldo Cruz , vol.85 , Issue.4 , pp. 533-538
    • Meirelles, M.N.1    Juliano, L.2    Carmona, E.3
  • 81
    • 0033817862 scopus 로고    scopus 로고
    • Cruzipain induces autoimmune response against skeletal muscle and tissue damage in mice
    • Giordanengo L, Fretes R, Diaz H et al. Cruzipain induces autoimmune response against skeletal muscle and tissue damage in mice. Muscle Nerve 23(9), 1407-1413 (2000).
    • (2000) Muscle Nerve , vol.23 , Issue.9 , pp. 1407-1413
    • Giordanengo, L.1    Fretes, R.2    Diaz, H.3
  • 82
    • 0033739239 scopus 로고    scopus 로고
    • Induction of antibodies reactive to cardiac myosin and development of heart alterations in cruzipain-immunized mice and their offspring
    • Giordanengo L, Maldonado C, Rivarola HW et al. Induction of antibodies reactive to cardiac myosin and development of heart alterations in cruzipain-immunized mice and their offspring. Eur J. Immunol. 30(11), 3181-3189 (2000).
    • (2000) Eur J. Immunol. , vol.30 , Issue.11 , pp. 3181-3189
    • Giordanengo, L.1    Maldonado, C.2    Rivarola, H.W.3
  • 83
    • 0141539329 scopus 로고    scopus 로고
    • Cruzipain induces autoantibodies against cardiac muscarinic acetylcholine receptors functional and pathological implications
    • Sterin-Borda L, Giordanengo L, Joensen L, Gea S. Cruzipain induces autoantibodies against cardiac muscarinic acetylcholine receptors. Functional and pathological implications. Eur. J. Immunol. 33(9), 2459-2468 (2003).
    • (2003) Eur. J. Immunol. , vol.33 , Issue.9 , pp. 2459-2468
    • Sterin-Borda, L.1    Giordanengo, L.2    Joensen, L.3    Gea, S.4
  • 84
    • 0031762029 scopus 로고    scopus 로고
    • Functionally active cardiac antibodies in chronic Chagas disease are specifically blocked by Trypanosoma cruzi antigens
    • Masuda MO, Levin M, De Oliveira SF et al. Functionally active cardiac antibodies in chronic Chagas' disease are specifically blocked by Trypanosoma cruzi antigens. FASEB J. 12(14), 1551-1558 (1998).
    • (1998) FASEB J. , vol.12 , Issue.14 , pp. 1551-1558
    • Masuda, M.O.1    Levin, M.2    De Oliveira, S.F.3
  • 85
    • 0027134811 scopus 로고
    • Kinetic analysis of antigen-specific immune responses in resistant and susceptible mice during infection with Trypanosoma cruzi
    • Hoft DF, Lynch RG, Kirchhoff LV. Kinetic analysis of antigen-specific immune responses in resistant and susceptible mice during infection with Trypanosoma cruzi. J. Immunol. 151(12), 7038-7047 (1993).
    • (1993) J. Immunol. , vol.151 , Issue.12 , pp. 7038-7047
    • Hoft, D.F.1    Lynch, R.G.2    Kirchhoff, L.V.3
  • 86
    • 41149162762 scopus 로고    scopus 로고
    • Sulfates are main targets of immune responses to cruzipain and are involved in heart damage in BALB/c immunized mice
    • Acosta DM, Arnaiz MR, Esteva MI et al. Sulfates are main targets of immune responses to cruzipain and are involved in heart damage in BALB/c immunized mice. Int. Immunol. 20(4), 461-470 (2008).
    • (2008) Int. Immunol. , vol.20 , Issue.4 , pp. 461-470
    • Acosta, D.M.1    Arnaiz, M.R.2    Esteva, M.I.3
  • 87
    • 79959187136 scopus 로고    scopus 로고
    • A striking common O-linked N-acetylglucosaminyl moiety between cruzipain and myosin
    • Acosta DM, Soprano LL, Ferrero M et al. A striking common O-linked N-acetylglucosaminyl moiety between cruzipain and myosin. Parasite Immunol. 33(7), 363-370 (2011).
    • (2011) Parasite Immunol. , vol.33 , Issue.7 , pp. 363-370
    • Acosta, D.M.1    Soprano, L.L.2    Ferrero, M.3
  • 88
    • 0035478484 scopus 로고    scopus 로고
    • Humoral immune response to cruzipain and cardiac dysfunction in chronic Chagas disease
    • Duschak VG, Riarte A, Segura EL, Laucella SA. Humoral immune response to cruzipain and cardiac dysfunction in chronic Chagas disease. Immunol. Lett. 78(3), 135-142 (2001).
    • (2001) Immunol. Lett. , vol.78 , Issue.3 , pp. 135-142
    • Duschak, V.G.1    Riarte, A.2    Segura, E.L.3    Laucella, S.A.4
  • 89
    • 9144241840 scopus 로고    scopus 로고
    • Immune response to a major Trypanosoma cruzi antigen cruzipain is differentially modulated in C57BL/6 and BALB/c mice
    • Guinazu N, Pellegrini A, Giordanengo L et al. Immune response to a major Trypanosoma cruzi antigen, cruzipain, is differentially modulated in C57BL/6 and BALB/c mice. Microbes Infect. 6(14), 1250-1258 (2004).
    • (2004) Microbes Infect. , vol.6 , Issue.14 , pp. 1250-1258
    • Guinazu, N.1    Pellegrini, A.2    Giordanengo, L.3
  • 90
    • 0034861163 scopus 로고    scopus 로고
    • Cardiac myosin autoimmunity in acute chagas heart disease
    • Leon JS, Godsel LM, Wang K, Engman DM. Cardiac myosin autoimmunity in acute Chagas' heart disease. Infect. Immun. 69(9), 5643-5649 (2001).
    • (2001) Infect. Immun. , vol.69 , Issue.9 , pp. 5643-5649
    • Leon, J.S.1    Godsel, L.M.2    Wang, K.3    Engman, D.M.4
  • 91
    • 38749145898 scopus 로고    scopus 로고
    • Elicitation of specific Th1-biased immune response precludes skeletal muscle damage in cruzipain-vaccinated mice
    • Frank FM, Cazorla SI, Sartori MJ, Corral RS. Elicitation of specific, Th1-biased immune response precludes skeletal muscle damage in cruzipain-vaccinated mice. Exp. Mol. Pathol. 84(1), 64-70 (2008).
    • (2008) Exp. Mol. Pathol. , vol.84 , Issue.1 , pp. 64-70
    • Frank, F.M.1    Cazorla, S.I.2    Sartori, M.J.3    Corral, R.S.4
  • 92
    • 36249011970 scopus 로고    scopus 로고
    • Spleen B cells from BALB/c are more prone to activation than spleen B cells from C57BL/6 mice during a secondary immune response to cruzipain
    • Pellegrini A, Guinazu N, Aoki MP et al. Spleen B cells from BALB/c are more prone to activation than spleen B cells from C57BL/6 mice during a secondary immune response to cruzipain. Int. Immunol. 19(12), 1395-1402 (2007).
    • (2007) Int. Immunol. , vol.19 , Issue.12 , pp. 1395-1402
    • Pellegrini, A.1    Guinazu, N.2    Aoki, M.P.3
  • 93
    • 16544387516 scopus 로고    scopus 로고
    • Determinations of B cell fate in immunity and autoimmunity
    • Noelle RJ, Erickson LD. Determinations of B cell fate in immunity and autoimmunity. Curr. Dir. Autoimmun. 8, 1-24 (2005).
    • (2005) Curr. Dir. Autoimmun. , vol.8 , pp. 1-24
    • Noelle, R.J.1    Erickson, L.D.2
  • 94
    • 32044454695 scopus 로고    scopus 로고
    • B cell tolerance checkpoints that restrict pathways of antigen-driven differentiation
    • William J, Euler C, Primarolo N, Shlomchik MJ. B cell tolerance checkpoints that restrict pathways of antigen-driven differentiation. J. Immunol. 176(4), 2142-2151 (2006).
    • (2006) J. Immunol. , vol.176 , Issue.4 , pp. 2142-2151
    • William, J.1    Euler, C.2    Primarolo, N.3    Shlomchik, M.J.4
  • 95
    • 82455222071 scopus 로고    scopus 로고
    • Trypanosoma cruzi antigen immunization induces a higher B cell survival in BALB/c mice a susceptible strain compared with C57BL/6 B lymphocytes a resistant strain to cardiac autoimmunity
    • Pellegrini A, Carrera-Silva EA, Arocena A, Cano RC, Aoki MP, Gea S. Trypanosoma cruzi antigen immunization induces a higher B cell survival in BALB/c mice, a susceptible strain, compared with C57BL/6 B lymphocytes, a resistant strain to cardiac autoimmunity. Med. Microbiol. Immunol. 200(4), 209-218 (2011).
    • (2011) Med. Microbiol. Immunol. , vol.200 , Issue.4 , pp. 209-218
    • Pellegrini, A.1    Carrera-Silva, E.A.2    Arocena, A.3    Cano, R.C.4    Aoki, M.P.5    Gea, S.6
  • 96
    • 38449099803 scopus 로고    scopus 로고
    • Cutting edge: I L-4-mediated protection of primary B lymphocytes from apoptosis via Stat6-dependent regulation of glycolytic metabolism
    • Dufort FJ, Bleiman BF, Gumina MR et al. Cutting edge: I L-4-mediated protection of primary B lymphocytes from apoptosis via Stat6-dependent regulation of glycolytic metabolism. J. Immunol. 179(8), 4953-4957 (2007).
    • (2007) J. Immunol. , vol.179 , Issue.8 , pp. 4953-4957
    • Dufort, F.J.1    Bleiman, B.F.2    Gumina, M.R.3
  • 97
    • 0347364686 scopus 로고    scopus 로고
    • Galectin-3 mediates IL-4-induced survival and differentiation of B cells: Functional cross-talk and implications during Trypanosoma cruzi infection
    • Acosta-Rodriguez EV, Montes CL, Motran CC et al. Galectin-3 mediates IL-4-induced survival and differentiation of B cells: functional cross-talk and implications during Trypanosoma cruzi infection. J. Immunol. 172(1), 493-502 (2004).
    • (2004) J. Immunol. , vol.172 , Issue.1 , pp. 493-502
    • Acosta-Rodriguez, E.V.1    Montes, C.L.2    Motran, C.C.3
  • 98
    • 67650422588 scopus 로고    scopus 로고
    • Vaccination approaches against Trypanosoma cruzi infection
    • Cazorla SI, Frank FM, Malchiodi EL. Vaccination approaches against Trypanosoma cruzi infection. Expert Rev. Vaccines 8(7), 921-935 (2009).
    • (2009) Expert Rev. Vaccines , vol.8 , Issue.7 , pp. 921-935
    • Cazorla, S.I.1    Frank, F.M.2    Malchiodi, E.L.3
  • 99
    • 0036718057 scopus 로고    scopus 로고
    • Cruzipain induces both mucosal and systemic protection against trypanosoma cruzi in mice
    • Schnapp AR, Eickhoff CS, Sizemore D, Curtiss R 3rd, Hoft DF. Cruzipain induces both mucosal and systemic protection against Trypanosoma cruzi in mice. Infect. Immun. 70(9), 5065-5074 (2002).
    • (2002) Infect. Immun. , vol.70 , Issue.9 , pp. 5065-5074
    • Schnapp, A.R.1    Eickhoff, C.S.2    Sizemore, D.3    Curtiss III, R.4    Hoft, D.F.5
  • 100
    • 0242352547 scopus 로고    scopus 로고
    • Use of a purified Trypanosoma cruzi antigen and CpG oligodeoxynucleotides for immunoprotection against a lethal challenge with trypomastigotes
    • Frank FM, Petray PB, Cazorla SI, Munoz MC, Corral RS, Malchiodi EL. Use of a purified Trypanosoma cruzi antigen and CpG oligodeoxynucleotides for immunoprotection against a lethal challenge with trypomastigotes. Vaccine 22(1), 77-86 (2003).
    • (2003) Vaccine , vol.22 , Issue.1 , pp. 77-86
    • Frank, F.M.1    Petray, P.B.2    Cazorla, S.I.3    Munoz, M.C.4    Corral, R.S.5    Malchiodi, E.L.6
  • 101
    • 40849124047 scopus 로고    scopus 로고
    • Prime-boost immunization with cruzipain co-administered with MALP-2 triggers a protective immune response able to decrease parasite burden and tissue injury in an experimental Trypanosoma cruzi infection model
    • Cazorla SI, Frank FM, Becker PD, Corral RS, Guzman CA, Malchiodi EL. Prime-boost immunization with cruzipain co-administered with MALP-2 triggers a protective immune response able to decrease parasite burden and tissue injury in an experimental Trypanosoma cruzi infection model. Vaccine 26(16), 1999-2009 (2008).
    • (2008) Vaccine , vol.26 , Issue.16 , pp. 1999-2009
    • Cazorla, S.I.1    Frank, F.M.2    Becker, P.D.3    Corral, R.S.4    Guzman, C.A.5    Malchiodi, E.L.6
  • 102
    • 37749054376 scopus 로고    scopus 로고
    • Oral vaccination with Salmonella enterica as a cruzipain-DNA delivery system confers protective immunity against Trypanosoma cruzi
    • Cazorla SI, Becker PD, Frank FM et al. Oral vaccination with Salmonella enterica as a cruzipain-DNA delivery system confers protective immunity against Trypanosoma cruzi. Infect. Immun. 76(1), 324-333 (2008).
    • (2008) Infect. Immun. , vol.76 , Issue.1 , pp. 324-333
    • Cazorla, S.I.1    Becker, P.D.2    Frank, F.M.3
  • 103
    • 68949200543 scopus 로고    scopus 로고
    • Two approaches to discovering and developing new drugs for Chagas disease
    • McKerrow JH, Doyle PS, Engel JC et al. Two approaches to discovering and developing new drugs for Chagas disease. Mem. Inst. Oswaldo Cruz 104(Suppl. 1), 263-269 (2009).
    • (2009) Mem. Inst. Oswaldo Cruz. , vol.104 , Issue.1 , pp. 263-269
    • McKerrow, J.H.1    Doyle, P.S.2    Engel, J.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.