Immune system recognition of Trypanosoma cruzi

Current Opinion in Immunology

Volumn 19, Issue 4, 2007, Pages 430-434

  Tarleton, Rick L ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; MEMBRANE PROTEIN; PEPTIDE; SIALIDASE;

ANTIGEN RECOGNITION; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; HOST CELL; HUMAN; IMMUNE SYSTEM; IN VIVO STUDY; INNATE IMMUNITY; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PROTOZOAL INFECTION; REVIEW; TRYPANOSOMA CRUZI;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CHAGAS DISEASE; DENDRITIC CELLS; HUMANS; IMMUNITY, NATURAL; MACROPHAGES; PROTOZOAN PROTEINS; PROTOZOAN VACCINES; TOLL-LIKE RECEPTORS; TRYPANOSOMA CRUZI;

EID: 34548021449     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2007.06.003     Document Type: Review

References (31)

1. Trinchieri G., and Sher A. Cooperation of Toll-like receptor signals in innate immune defence. Nat Rev Immunol 7 (2007) 179-190
2. Koga R., Hamano S., Kuwata H., Atarashi K., Ogawa M., Hisaeda H., Yamamoto M., Akira S., Himeno K., Matsumoto M., et al. TLR-dependent induction of IFN-beta mediates host defense against Trypanosoma cruzi. J Immunol 177 (2006) 7059-7066. The first demonstration that IFN-beta and its induction of IRG47 plays a significant role in macrophage and host control of T. cruzi infection.
3. Campos M.A., Almeida I.C., Takeuchi O., Akira S., Valente E.P., Procopio D.O., Travassos L.R., Smith J.A., Golenbock D.T., and Gazzinelli R.T. Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite. J Immunol 167 (2001) 416-423
4. Ouaissi A., Guilvard E., Delneste Y., Caron G., Magistrelli G., Herbault N., Thieblemont N., and Jeannin P. The Trypanosoma cruzi Tc52-released protein induces human dendritic cell maturation, signals via Toll-like receptor 2, and confers protection against lethal infection. J Immunol 168 (2002) 6366-6374
5. Ropert C., and Gazzinelli R.T. Regulatory role of Toll-like receptor 2 during infection with Trypanosoma cruzi. J Endotoxin Res 10 (2004) 425-430
6. Campos M.A., Closel M., Valente E.P., Cardoso J.E., Akira S., Alvarez-Leite J.I., Ropert C., and Gazzinelli R.T. Impaired production of proinflammatory cytokines and host resistance to acute infection with Trypanosoma cruzi in mice lacking functional myeloid differentiation factor 88. J Immunol 172 (2004) 1711-1718
7. Bafica A., Santiago H.C., Goldszmid R., Ropert C., Gazzinelli R.T., and Sher A. Cutting edge: TLR9 and TLR2 signaling together account for MyD88-dependent control of parasitemia in Trypanosoma cruzi infection. J Immunol 177 (2006) 3515-3519. T. cruzi GPI-anchors and DNA signal via TLR2 and TLR9, respectively and cooperatively participate in in vivo control of infection.
8. Shoda L.K., Kegerreis K.A., Suarez C.E., Roditi I., Corral R.S., Bertot G.M., Norimine J., and Brown W.C. DNA from protozoan parasites Babesia bovis, Trypanosoma cruzi, and T. brucei is mitogenic for B lymphocytes and stimulates macrophage expression of interleukin-12, tumor necrosis factor alpha, and nitric oxide. Infect Immun 69 (2001) 2162-2171
9. Monteiro A.C., Schmitz V., Svensjo E., Gazzinelli R.T., Almeida I.C., Todorov A., de Arruda L.B., Torrecilhas A.C., Pesquero J.B., Morrot A., et al. Cooperative activation of TLR2 and bradykinin B2 receptor is required for induction of type 1 immunity in a mouse model of subcutaneous infection by Trypanosoma cruzi. J Immunol 177 (2006) 6325-6335
10. Petersen C.A., Krumholz K.A., and Burleigh B.A. Toll-like receptor 2 regulates interleukin-1beta-dependent cardiomyocyte hypertrophy triggered by Trypanosoma cruzi. Infect Immun 73 (2005) 6974-6980
11. Vaena de Avalos S., Blader I.J., Fisher M., Boothroyd J.C., and Burleigh B.A. Immediate/early response to Trypanosoma cruzi infection involves minimal modulation of host cell transcription. J Biol Chem 277 (2002) 639-644
12. Creagh E.M., and O'Neill L.A. TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity. Trends Immunol 27 (2006) 352-357
13. Lieke T., Graefe S.E., Klauenberg U., Fleischer B., and Jacobs T. NK cells contribute to the control of Trypanosoma cruzi infection by killing free parasites by perforin-independent mechanisms. Infect Immun 72 (2004) 6817-6825
14. Lieke T., Steeg C., Graefe S.E., Fleischer B., and Jacobs T. Interaction of natural killer cells with Trypanosoma cruzi-infected fibroblasts. Clin Exp Immunol 145 (2006) 357-364
15. Duthie M.S., and Kahn S.J. NK cell activation and protection occur independently of natural killer T cells during Trypanosoma cruzi infection. Int Immunol 17 (2005) 607-613
16. Garg N., Nunes M.P., and Tarleton R.L. Delivery by Trypanosoma cruzi of proteins into the MHC class I antigen processing and presentation pathway. J Immunol 158 (1997) 3293-3302
17. Martin D., and Tarleton R. Generation, specificity, and function of CD8+ T cells in Trypanosoma cruzi infection. Immunol Rev 201 (2004) 304-317
18. El-Sayed N.M., Myler P.J., Bartholomeu D.C., Nilsson D., Aggarwal G., Tran A.N., Ghedin E., Worthey E.A., Delcher A.L., Blandin G., et al. The genome sequence of Trypanosoma cruzi, etiologic agent of Chagas disease. Science 309 (2005) 409-415. The sequence and annotation of the T. cruzi CL Brener strain genome.
19. Atwood III J.A., Weatherly D.B., Minning T.A., Bundy B., Cavola C., Opperdoes F.R., Orlando R., and Tarleton R.L. The Trypanosoma cruzi proteome. Science 309 (2005) 473-476. Whole organism proteomic analysis of the four major life cycle stages of T. cruzi.
20. Martin D.L., Weatherly D.B., Laucella S.A., Cabinian M.A., Crim M.T., Sullivan S., Heiges M., Craven S.H., Rosenberg C.S., Collins M.H., et al. CD8+ T-Cell responses to Trypanosoma cruzi are highly focused on strain-variant trans-sialidase epitopes. PLoS Pathog 2 (2006) e77. The first broad search for targets of CD8+ T cells in T. cruzi and the identification of trans-sialidase peptides as specific, immunodominant epitopes for T. cruzi -specific CD8+T cells.
21. Fonseca S.G., Moins-Teisserenc H., Clave E., Ianni B., Nunes V.L., Mady C., Iwai L.K., Sette A., Sidney J., Marin M.L., et al. Identification of multiple HLA-A*0201-restricted cruzipain and FL-160 CD8+ epitopes recognized by T cells from chronically Trypanosoma cruzi-infected patients. Microbes Infect 7 (2005) 688-697
22. Diez H., Lopez M.C., Del Carmen Thomas M., Guzman F., Rosas F., Velazco V., Gonzalez J.M., and Puerta C. Evaluation of IFN-gamma production by CD8 T lymphocytes in response to the K1 peptide from KMP-11 protein in patients infected with Trypanosoma cruzi. Parasite Immunol 28 (2006) 101-105
23. Minoprio P., Itohara S., Heusser C., Tonegawa S., and Coutinho A. Immunobiology of murine T. cruzi infection: The predominance of parasite-nonspecific responses and the activation of TCRI T cells. Immunol. Rev. 112 (1989) 183-207
24. Minoprio P.M., Coutinho A., Joskowicz M., D'Imperio M.R., and Eisen H. Polyclonal lymphocyte responses to murine Trypanosoma cruzi infection. II. Cytotoxic T lymphocytes. Scand. J. Immunol. 24 (1986) 669-679
25. Miyahira Y., Takashima Y., Kobayashi S., Matsumoto Y., Takeuchi T., Ohyanagi-Hara M., Yoshida A., Ohwada A., Akiba H., Yagita H., et al. Immune responses against a single CD8+-T-cell epitope induced by virus vector vaccination can successfully control Trypanosoma cruzi infection. Infect Immun 73 (2005) 7356-7365
26. Araujo A.F., de Alencar B.C., Vasconcelos J.R., Hiyane M.I., Marinho C.R., Penido M.L., Boscardin S.B., Hoft D.F., Gazzinelli R.T., and Rodrigues M.M. CD8+-T-cell-dependent control of Trypanosoma cruzi infection in a highly susceptible mouse strain after immunization with recombinant proteins based on amastigote surface protein 2. Infect Immun 73 (2005) 6017-6025
27. Zapata-Estrella H., Hummel-Newell C., Sanchez-Burgos G., Escobedo-Ortegon J., Ramirez-Sierra M.J., Arjona-Torres A., and Dumonteil E. Control of Trypanosoma cruzi infection and changes in T-cell populations induced by a therapeutic DNA vaccine in mice. Immunol Lett 103 (2006) 186-191
28. Machado A.V., Cardoso J.E., Claser C., Rodrigues M.M., Gazzinelli R.T., and Bruna-Romero O. Long-term protective immunity induced against Trypanosoma cruzi infection after vaccination with recombinant adenoviruses encoding amastigote surface protein-2 and trans-sialidase. Hum Gene Ther 17 (2006) 898-908
29. Callejas S., Leech V., Reitter C., and Melville S. Hemizygous subtelomeres of an African trypanosome chromosome may account for over 75% of chromosome length. Genome Res 16 (2006) 1109-1118
30. Tzelepis F., de Alencar B.C., Penido M.L., Gazzinelli R.T., Persechini P.M., and Rodrigues M.M. Distinct kinetics of effector CD8+ cytotoxic T cells after infection with Trypanosoma cruzi in naive or vaccinated mice. Infect Immun 74 (2006) 2477-2481
31. Tzelepis F., Persechini P.M., and Rodrigues M.M. Modulation of CD4 T cell-dependent specific cytotoxic CD8 T cells differentiation and proliferation by the timing of increase in the pathogen load. PLoS ONE 2 (2007) e393. Further support for a delayed initiation of CD8+T cell responses in murine T. cruzi infection.