Impaired innate immunity in Tlr4-/- mice but preserved CD8+ T cell responses against trypanosoma cruzi in Tlr4-, Tlr2-, Tlr9- or myd88-deficient mice

PLoS Pathogens

Volumn 6, Issue 4, 2010, Pages 1-16

  Oliveira, Ana Carolina ^a   de Alencar, Bruna C ^b   Tzelepis, Fanny ^b   Klezewsky, Weberton ^a   da Silva, Raquel N ^a   Neves, Fabieni S ^a   Cavalcanti, Gisele S ^a   Boscardin, Silvia ^c   Nunes, Marise P ^d   Santiago, Marcelo F ^a   Nóbrega, Alberto ^a   Rodrigues, Maurício M ^b   Bellio, Maria ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; MYD88 PROTEIN, MOUSE; MYELOID DIFFERENTIATION FACTOR 88; TLR2 PROTEIN, MOUSE; TLR4 PROTEIN, MOUSE; TLR9 PROTEIN, MOUSE; TOLL LIKE RECEPTOR 9;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL INVASION; CHAGAS DISEASE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME INHIBITION; HOST CELL; IMMUNE RESPONSE; INNATE IMMUNITY; LYSOSOME; MACROPHAGE; MORTALITY; MOUSE; NONHUMAN; PARASITE SURVIVAL; PARASITEMIA; PASSIVE IMMUNIZATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; SPLEEN; SPLEEN CELL; TRYPANOSOMA CRUZI; TRYPOMASTIGOTE; ANIMAL; C57BL MOUSE; GENETICS; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; MOUSE MUTANT;

ANIMALIA; MURINAE; MUS; PROTOZOA; TRYPANOSOMA CRUZI;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CHAGAS DISEASE; IMMUNITY, INNATE; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYELOID DIFFERENTIATION FACTOR 88; NITRIC OXIDE SYNTHASE TYPE II; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTOR 9; TRYPANOSOMA CRUZI;

EID: 77954049583     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1000870     Document Type: Article

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