Trypanosoma cruzi and its components as exogenous mediators of inflammation recognized through Toll-like receptors

Mediators of Inflammation

Volumn 13, Issue 3, 2004, Pages 139-143

  Campos, Marco A ^a   Gazzinelli, Ricardo T ^a,b  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Glycosylphosphatidylinositol; Host defense; Inflammation; Innate immune response; Toll like receptors; Trypanosoma cruzi

Indexed keywords

AUTACOID; CD14 ANTIGEN; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 2;

ANTIGEN RECOGNITION; CHAGAS DISEASE; IMMUNE RESPONSE; INFLAMMATION; MACROPHAGE ACTIVATION; MOLECULAR RECOGNITION; MORTALITY; NONHUMAN; PARASITE IMMUNITY; PARASITEMIA; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; SOUTH AND CENTRAL AMERICA; TRYPANOSOMA CRUZI;

ANIMALS; CHAGAS DISEASE; HUMANS; INFLAMMATION; MEMBRANE GLYCOPROTEINS; RECEPTORS, CELL SURFACE; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTORS; TRYPANOSOMA CRUZI;

PROTOZOA; TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 4143132253     PISSN: 09629351     EISSN: None     Source Type: Journal    
DOI: 10.1080/09511920410001713565     Document Type: Review

References (38)

1. Metschnikoff I. Ueber eine Sprosspilzkrankheit der Daphnien. Beitrag zur Lehre uber den Kampf der Phagocyten gegen Krankheitserreger. Archiv pathol Anat Physiol klin Med 1884; 96: 177-195.
2. Erlich P. Experimentelle Untersuchungen uber Immunitat, I. Ueber Ricin, II. Ueber Abrin. Deutsche Med Wchnschr 1891; 976: 1218-1231.
3. Janeway CA, Jr. Medzhitov R. Innate immune recognition. Annu Rev Immunol 2002; 20: 197-216.
4. Larsen GL, Henson PM. Mediators of inflammation. Ann Rev Immunol 1983; 1: 335-359.
5. Anderson KV, Jurgens G, Nusslein-Volhard C. Establishment of dorsal-ventral polarity in the Drosophila embryo: genetic studies on the role of the Toll gene product. Cell 1985; 42: 779-789.
6. Anderson KV, Bokla L, Nusslein-Volhard C. Establishment of dorsal-ventral polarity in the Drosophila embryo: the induction of polarity by the Toll gene product. Cell 1985; 42: 791-798.
7. Lemaitre B, Nicolas E, Michaut L, Reichhart JM, Hoffmann JA. The dorsoventral regulatory gene cassette Spatzle/Toll/Cactus controls the potent antifungal response in Drosophila adults. Cell 1996; 86: 973-983.
8. Medzhitov R, Preston-Hurlburt P, Janeway CA, Jr. A human homologue of the Drosophila toll protein signals activation of adaptive immunity. Nature 1997; 388: 394-397.
9. Rock FL, Hardiman G, Timans JC, Kostelein RA, Bozon JF. A family of human receptors structurally related to Drosophila Toll. Proc Natl Acad Sci USA 1998; 95: 588-593.
10. Poltorak A, He X, Smirnova I, et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in TLR4 gene. Science 1998; 282: 2085-2088.
11. Lien E, Means TK, Heine H, et al. Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide. J Clin Invest 2000; 105: 497-504.
12. Werts C, Tapping RI, Mathison JC, et al. Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism. Nat Immunol 2001; 2: 346-352.
13. Campos MA, Rosinha GMS, Almeida IC, et al. The role of toll-like receptor 4 in induction of cell-mediated immunity and resistance to Brucella abortus infection in mice. Infect Immun 2004; 72: 176-186.
14. Lien E, Sellati TJ, Yoshimura A, et al. Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J Biol Chem 1999; 274: 33419-33425.
15. Takeuchi O, Hoshino K, Kawai T, et al. Differential roles of TLR2 and TLR4 in recognition of Gram negative and Gram positive bacterial cell wall components. Immunity 1999; 11: 443-451.
16. Hemmi H, Takeuchi O, Kawai T, et al. A Toll-like receptor recognizes bacterial DNA. Nature 2000; 408: 740-745.
17. Kurt-Jones EA, Popova L, Kwinn L, et al. Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat Immunol 2000; 1: 398-401.
18. Hayashi F, Smith KD, Ozinsky A, et al. The innate immune response to bacterial flagelin is mediated by Toll-like receptor 5. Nature 2001; 410: 1099-1103.
19. Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NFKB by Toll-like receptor 3. Nature 2001; 413: 432-438.
20. Campos MA, Almeida IC, Takeuchi O, et al. Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasite. J Immunol 2001; 167: 416-423.
21. Ozinsky A, Underhill DM, Fontenot JD, et al. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors. Proc Natl Acad Sci USA 2000; 97: 13766-13771.
22. Takeda K, Kaisho T, Akira S. Toll-like receptors. Annu Rev Immunol 2003; 21: 335-376.
23. Adachi O, Kawai T, Takeda K, et al. Targeted disruption of the MyD88 gene results in loss of IL-1 and IL-18-mediated function. Immunity 1998; 9: 143-150.
24. Kawai T, Adachi O, Ogawa T, Takeda K, Akira S. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 1999; 11: 115-122.
25. Camargo MM, Almeida IC, Pereira MES, Ferguson MA, Travassos LR, Gazzinelli RT. Glycosylphosphatidylinositol anchored mucin-like glycoproteins isolated from Trypanosoma cruzi tripomastigotes initiate the synthesis of proinflammatory cytokines by macrophages. J Immunol 1997; 158: 5980-5991.
26. Almeida IC, Camargo MM, Procopio DO, et al. Highly-purified glycosylphosphatidylinositols from Trypanosoma cruzi are potent proinflammatory agents. EMBO J 2000; 19: 1476-1485.
27. Almeida IC, Gazzinelli RT. Proinflammatory activity of glycosylphosphatidylinositol anchors derived from Trypanosoma cruzi: structural and functional analysis. J Leuk Biol 2001; 70: 467-477.
28. Freire-de-Lima CG, Nunes MP, Corte-Real S, Soares MP, Previato JO, Mendonça-Previato L, Dos Reis GA. Proapoptotic activity of a Trypanosoma cruzi ceramide-containing glycolipid turned on in host macrophages by IFNγ. J Immunol 1998; 161: 4909-4916.
29. Ropert C, Almeida IC, Closel M, Travassos LR, Ferguson MA, Cohen P, Gazzinelli RT. Requirement of MAP kinases and IkB phosphorylation for induction of proinflammatory cytokines by macrophages indicates functional similarity of receptors triggered by glycosylphosphatidylinositol anchors from parasitic protozoa and bacterial LPS. J Immunol 2001; 166: 3423-3431.
30. Zhang H, Tay PN, Cao W, Li W, Lu J. Integrin-nucleated Toll-like receptor (TLR) dimerization reveals subcellular targeting of TLRs and distinct mechanisms of TLR4 activation and signaling. FEBS Lett 2002; 532: 171-176.
31. Sabroe I, Read RC, Whyte MKB, Dockrell DH, Vogel SN, Dower SK. Toll-like receptors in Health and Disease: Complex questions remain. J Immunol 2003; 171: 1030-1035.
32. Kerppola T, Curran T. Transcription. Zen and the art of Fos and Jun. Nature 1995; 373: 199-200.
33. Campos MAS, Kroon EG, Gentz R, Ferreira PCP. Protein domains involved in nuclear transport of Fos. Cell Biol Int 1999; 23: 81-88.
34. Hunter T, Karin M. The regulation of transcription by phosphorylation. Cell 1992; 70: 375-387.
35. Kaisho T, Akira S. Dendritic-cell function in Toll-like receptor and MyD88-knock out mice. Trends Immunol 2001; 22: 78-83.
36. Campos MA, Closel M, Valente EP, et al. Impaired production of proinflammatory cytokines and host resistance to acute infection with Trypanosoma cruzi in mice lacking functional myeloid differentiation factor 88. J Immunol 2004; 172: 1711-1718.
37. Oliveira AC, Peixoto JR, Arruda LB. TLR4 functional expression confers proinflammatory responsiveness to Trypanosoma cruzi glycoinositol-phospholipids and higher resistance to infection with T. cruzi from Trypanosoma cruzi (submitted)
38. Shoda LK, Kegerreis KA, Suarez CE, et al. DNA from protozoan parasites Babesia bovis, Trypanosoma cruzi, and T. brucei is mitogenic for B lymphocytes and stimulates macrophage expression of interleukin-12, tumor necrosis factor alpha, and nitric oxide. Infect Immunol 2001; 69: 2162-2171.