Cruzipain induces autoantibodies against cardiac muscarinic acetylcholine receptors. Functional and pathological implications

European Journal of Immunology

Volumn 33, Issue 9, 2003, Pages 2459-2468

  Sterin Borda, Leonor ^a   Giordanengo, Laura ^b   Joensen, Lilian ^c   Gea, Susana ^b  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b UNIVERSIDAD NACIONAL DE CÓRDOBA   (Argentina)

^c Administracion Nacional de Laboratorios E Institutos de Salud Dr Carlos G Malbran   (Argentina)

Author keywords

Autoantibodies; Cardiac cholinoceptors; Chagas' disease; Cruzipain; Myocardial contractility

Indexed keywords

ADENYLATE CYCLASE; AUTOANTIBODY; CHOLINERGIC RECEPTOR ANTIBODY; CRUZIPAIN; CYCLIC GMP; HEART RECEPTOR; IMMUNOGLOBULIN FRAGMENT; IMMUNOGLOBULIN G; INOSITOL PHOSPHATE; MUSCARINIC M2 RECEPTOR; NITRIC OXIDE SYNTHASE; QUINUCLIDINYL BENZILATE; SYNTHETIC PEPTIDE; TRITIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY DETECTION; ANTIBODY PRODUCTION; ANTIGEN ANTIBODY REACTION; ANTIGEN PURIFICATION; ARTICLE; CHAGAS DISEASE; CONTROLLED STUDY; DYSAUTONOMIA; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEART MUSCLE CONTRACTILITY; HEART RATE; IMMUNIZATION; IMMUNOAFFINITY CHROMATOGRAPHY; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RADIOASSAY; RECEPTOR BINDING; TRYPANOSOMA CRUZI;

ANIMALS; AUTOANTIBODIES; CHAGAS DISEASE; CYSTEINE ENDOPEPTIDASES; MICE; MICE, INBRED BALB C; MYOCARDIUM; RECEPTORS, MUSCARINIC; TRYPANOSOMA CRUZI;

EID: 0141539329     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200324009     Document Type: Article

References (24)

1. Hontebeyrie-Joscowicz, M. and Minoprio, P., Chagas disease: Trypanosoma cruzi vs. the host immune system. Res. Immunol. 1991. 142: 125-181.
2. Cossio, P. M., Laguens, R., Kreutzer, E., Diez, C., Segal, A. and Arana, R. M., Chagasic cardiophaty: immunopathology and morphological studies in myocardial byopsies. Am. J. Pathol. 1977. 7: 743-745.
3. Girones, N., Rodriguez, C. I., Carrasco-Marin, E., Flores Hernaez, R., Lopez de Rego, J. and Fresno, M., Dominant T- and B-cell epitopes in an autoantigen linked to Chagas' disease. J. Clin. Invest. 2001. 107: 985-993.
4. Giordanengo, L., Gea, S., Barbieri, G. and Rabinovich, G., Anti-galactin-1 autoantibodies in human T. cruzi infection: differential expression of these β-galactoside-binding proteins in cardiac Chagas' disease. Clin. Exp. Immunol. 2001. 124: 266-273.
5. Goin, J. C., Perez Leiros, C., Borda, E. and Sterin-Borda, L., Interaction of human chagasic IgG with the second extracellular loop of the human heart muscarinic acetylcholine receptor: functional and pathological implications. FASEB J. 1997. 10: 77-83.
6. Sterin-Borda, L., Perez Leiros, C., Goin, J. C., Cremaschi, G., Genaro, A., Vila Echague, A. and Borda, E., Participation of nitric oxide signalling system in the cardiac muscarinic cholinergic effect of human chagasic IgG. J. Mol. Cell. Cardiol. 1997. 29: 1851-1865.
7. Sterin-Borda, L., Gorelik, G. and Borda, E., Chagasic IgG binding with cardiac muscarinic cholinergic receptor modifies cholinergic-mediated cellular transmembrane signals. Clin. Immunol. Immunopathol. 1991. 61: 389-397.
8. Sterin-Borda, L. and Borda, E., Role of neurotransmitter autoantibodies in the pathogenesis of chagasic peripheral dysautonomia. Ann. N. Y. Acad. Sci. 2000. 917: 273-280.
9. Borda, E., Sterin-Borda, L., Pascual, J., Gorelik, G., Felix, J. C., von Kreuter, B. and Santos-Buch, C. A., Trypanosoma cruzi attachment to lymphocyte muscarinic cholinergic and beta adrenergic receptors modulates intracellular signal transduction. Mol. Biochem. Parasitol. 1991. 47: 91-100.
10. von Kreuter, B. and Santos-Buch, C. A., Modulation of Trypanosoma cruzi adhesion to host muscle cell membranes by ligands of muscarinic cholinergic and beta adrenergic receptors. Mol. Biochem. Parasitol. 1989. 36: 41-50.
11. Eakin, A. E., Mills, A. A., Harth, G., McKerrow, J. H. and Craik, C. S., The sequence, organization, and expression of the major cystein protease (cruzain) from Trypanosoma cruzi. J. Biol. Chem. 1992. 267: 7411-7420.
12. Cazzulo, J. J., Stoka, V. and Turk, V., Cruzipain, the major cystein proteinase from the protozoan parasite Trypanosoma cruzi. Biol. Chem. 1997. 378: 1-10.
13. Arnholdt, A. C., Piuvezam, M. R., Russo, D. M., Lima, A. P., Pedrosa, R. C., Reed, S. G. and Scharfstein, J., Analysis and partial epitope mapping of human T cell response to T. cruzi cysteinyl proteinase. J. Immunol. 1993. 151: 3171-3179.
14. Giordanengo, L., Fretes, R., Diaz, H., Cano, R., Bacile, A., Vottero-Cima, E. and Gea, S., Cruzipain induces autoimmune response against skeletal muscle and tissue damage in mice. Muscle Nerve 2000. 23: 1407-1413.
15. Giordanengo, L., Maldonado, C., Rivarola, H. W., Iosa, D., Girones, N., Fresno, M. and Gea, S., Induction of antibodies reactive to cardiac myosin and development of heart alterations in cruzipain-immunized mice and their offspring. Eur. J. Immunol. 2000. 30: 3181-3189.
16. Giordanengo, L., Guiñazu, N., Stempin, C., Fretes, R., Cerban, F. and Gea, S., Cruzipain, a major Trypanosoma cruzi antigen, conditions the host immune response in favor of parasite. Eur. J. Immunol. 2002. 32: 1003-1011.
17. 2 muscarinic cholinoceptor activation by human chagasic autoantibodies: association with bradycardia. Heart 1999. 82: 273-278.
18. Sterin-Borda, L., Vila Echague, A., Perez Leiros, C., Genaro, A. and Borda, E., Endogenous nitric acid signalling system and the cardiac muscarinic acetylcholine receptor-ionotropic response. Br. H. Pharmacol. 1995. 115: 1525-1531.
19. Sterin-Borda, L., Gorelik, G., Genaro, A., Goin, J. C. and Borda, E., Human chagasic IgG interaction with lymphocyte neurotransmitter receptors triggers intracellular signal transduction. FASEB J. 1990. 4: 1661-1667.
20. 2 muscarinic acetylcholine receptors by autoantibodies from patients with Chagas' disease. J. Biol. Chem. 1997. 272: 12989-12993.
21. Sterin-Borda, L., Joensen, L., Bayo-Hanza, C., Esteva, M. and Borda, E., Therapeutic use of muscarinic acetylcholine receptor peptide to prevent mice chagasic cardiac dysfunction. J. Mol. Cell. Cardiol. 2002. 34: 1645-1654.
22. Sterin-Borda, L., Goin, J., Bilder, C., Iantorno, M., Hernandez, A. C. and Borda, E., Interactions of human chagasic IgG, with human colon muscarinic actylcholine receptor: Molecular and functional evidence. Gut 2001. 49: 699-705.
23. Goin, J. C., Sterin-Borda, L., Bilder, C., Monastra, L., Iantorno, M. and Borda, E., Pathological implications of circulating mAChR antibodies in chagasic patients with achalasia. Gastroenterology 1999. 117: 798-805
24. Perez Leiros, C., Goren, N., Sterin-Borda, L., Lustig, L. and Borda, E., Alterations in cardiac muscarinic acetylcholine receptors in mice with autoimmune myocarditis and association with circulating muscarinic receptor-related autoantibodies. Clin. Auton. Res. 1994. 4: 249-255.