Increased susceptibility of stat4-deficient and enhanced resistance in stat6-deficient mice to infection with Trypanosoma cruzi

Journal of Immunology

Volumn 165, Issue 3, 2000, Pages 1520-1525

  Tarleton, Rick L ^a   Grusby, Michael J ^b   Zhang, Lei ^a,c  

^a UNIVERSITY OF GEORGIA   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE;

ANIMAL TISSUE; ARTICLE; CYTOKINE PRODUCTION; IMMUNITY; IMMUNOHISTOCHEMISTRY; INFECTION SENSITIVITY; MOUSE; NONHUMAN; PARASITEMIA; PRIORITY JOURNAL; TH1 CELL; TH2 CELL; TRYPANOSOMA CRUZI;

EID: 0034254417     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.3.1520     Document Type: Article

References (49)

1. Castanos-Velez, E., S. Maerlan, L. M. Osorio, F. Aberg, P. Biberfeld, A. Orn, and M. E. Rottenberg. 1998. Trypanosoma cruzi infection in tumor necrosis factor receptor p55-deficient mice. Infect. Immun. 66:2960.
2. Holscher, C., G. Kohler, U. Muller, H. Mossmann, G. A. Schaub, and F. Brombacher. 1998. Defective nitric oxide effector functions lead to extreme susceptibility of Trypanosoma cruzi-infected mice deficient in γ interferon receptor or inducible nitric oxide synthase. Infect. Immun. 66:1208.
3. Rottenberg, M. E., A. Riarte, L. Sporrong, J. Altcheh, P. Petray, A. M. Ruiz, H. Wigzell, and A. Orn. 1995. Outcome of infection with different strains of Trypanosoma cruzi in mice lacking CD4 and/or CD8. Immunol. Lett. 45:53.
4. + T cell function to immune control of Trypanosama cruzi. Parasite Immunity 20:207.
5. Tarleton, R. L., M. J. Grusby, M. Postan, and L. H. Glimcher. 1996. Trypanosoma cruzi infection in MHC-deficient mice: further evidence for the role of both class I-and class II-restricted T cells in immune resistance and disease. Int. Immunol. 8:13.
6. 2-microglobulin-deficient mice to Trypanosoma cruzi infection. Nature 356: 338.
7. Torrico, F., H. Heremans, M. T. Rivera, E. Van Marck, A. Billiau, and Y. Carlier. 1991. Endogenous IFN-γ is required for resistance to acute Trypanosoma cruzi infection in mice. J. Immunol. 146:3626.
8. Reed, S. G. 1988. In vivo administration of recombinant IFN-γ induces macrophage activation, and prevents acute disease, immune suppression, and death in experimental Trypanosoma cruzi infections. J. Immunol. 140:4342.
9. Hoft, D. F., R. G. Lynch, and L. V. Kirchhoff. 1993. Kinetic analysis of antigen-specific immune responses in resistant and susceptible mice during infection with Trypanosoma cruzi. J. Immunol. 151:7038.
10. Hunter, C. A., T. Slifer, and F. Araujo. 1996. Interleukin-12-mediated resistance to Trypanosoma cruzi is dependent on tumor necrosis factor α and γ interferon. Infect. Immun. 64:2381.
11. Abrahamsohn, I. A., and R. L. Coffman. 1995. Trypanosoma cruzi: IL-10, TNF, IFN-γ, and IL-12 regulate innate and acquired immunity to infection. Exp. Parasitol. 84:231.
12. + lymphocytes increase in vivo susceptibility to Trypanosoma cruzi infection. Cell. Immunol. 170:41.
13. Reed, S. G., C. E. Brownell, D. M. Russo, J. S. Silva, K. H. Grabstein, and P. J. Morrissey. 1994. IL-10 mediates susceptibility to Trypanosoma cruzi infection. J. Immunol. 153:3135.
14. Petray, P. B., M. E. Rottenberg, G. Bertot, R. S. Corral, A. Diaz, A. Orn, and S. Grinstein. 1993. Effect of anti-γ-interferon and anti-interleukin-4 administration on the resistance of mice against infection with reticulotropic and myotropic strains of Trypanosoma cruzi. Immunol. Lett. 35:77.
15. Rottenberg, M. E., L. Sporrong, I. Persson, H. Wigzell, and A. Orn. 1995. Cytokine gene expression during infection of mice lacking CD4 and/or CD8 with Trypanosoma cruzi. Scand. J. Immunol. 41:164.
16. Zhang, L., and R. L. Tarleton. 1996. Persistent production of inflammatory and anti-inflammatory cytokines and associated MHC and adhesion molecule expression at the site of infection and disease in experimental Trypanosoma cruzi infections. Exp. Parasitol. 84:203.
17. Zhang, L., and R. L. Tarleton. 1996. Characterization of cytokine production in murine Trypanosoma cruzi infection by in situ immunocytochemistry: lack of association between susceptibility and type 2 cytokine production. Eur. J. Immunol. 26:102.
18. Leonard, W. J., and J. J. O'Shea. 1998. Jaks and STATs: biological implications. Annu. Rev. Immunol. 16:293.
19. Takeda, K., T. Tanaka, W. Shi, M. Matsumoto, M. Minami, S. Kashiwamura, K. Nakanishi, N. Yoshida, T. Kishimoto, and S. Akira. 1996. Essential role of Stat6 in IL-4 signalling. Nature 380:627.
20. Kaplan, M. H., U. Schindler, S. T. Smiley, and M. J. Grusby. 1996. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 4:313.
21. Grusby, M. J. 1997. Stat4-and Stat6-deficient mice as models for manipulating T helper cell responses. Biochem. Soc Trans. 25:359.
22. Thierfelder, W. E., J. M. van Deursen, K. Yamamoto, R. A. Tripp, S. R. Sarawar, R. T. Carson, M. Y. Sangster, D. A. Vignali, P. C. Doherty, G. C. Grosveld, and J. N. Ihle. 1996. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 382:171.
23. Kaplan, M. H., Y. L. Sun, T. Hoey, and M. J. Grusby. 1996. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382:174.
24. Tarleton, R. L., P. P. Andrade, and C. R. Andrade. 1988. Interleukin 2 production in patients with Chagas' disease: correlation with anti-parasite antibody responses. Immunol. Lett. 17:229.
25. Tarleton, R. L., L. Zhang, and M. O. Downs. 1997. "Autoimmune rejection" of neonatal heart transplants in experimental Chagas' disease is a parasite-specific response to infected host tissue. Proc. Natl. Acad. Sci. USA 94:3932.
26. Zhang, L., and R. L. Tarleton. 1999. Parasite persistence correlates with disease severity and localization in chronic Chagas disease. J. Infect. Dis. In press.
27. Tarleton, R. L., and L. Zhang. 1999. Chagas disease etiology: autoimmunity or parasite persistence? Parasitol. Today 15:94.
28. Louis, J., H. Himmelrich, C. Parra-Lopez, F. Tacchini-Cottier, and P. Launois. 1998. Regulation of protective immunity against Leishmania major in mice, Curr. Opin. Immunol. 10:459.
29. + effector T cells and susceptibility to infectious diseases. Adv. Exp. Med. Biol. 452:45.
30. Denkers, E. Y., and R. T. Gazzinelli. 1998. Regulation and function of T-cell-mediated immunity during Toxoplasma gondii infection. Clin. Microbiol. Rev. 11:569.
31. Hartmann, P., and G. Plum. 1999. Immunological defense mechanisms in tuberculosis and MAC-infection. Diagn. Microbiol. Infect. Dis. 34:147.
32. DosReis, G. A. 1997. Cell-mediated immunity in experimental Trypanosoma cruzi infection. Parasitol. Today 13:335.
33. Tarleton, R. L. 1997. Immunity to Trypanosoma cruzi. In Host Response to Intracellular Pathogens. S. H. E. Kaufmann, ed. R.G. Landes Company, Austin, p. 227.
34. Marinho, C. R., M. R. D'Imperio Lima, M. G. Grisotto, and J. M. Alvarez. 1999. Influence of acute-phase parasite load on pathology, parasitism, and activation of the immune system at the late chronic phase of Chagas' disease. Infect. Immun. 67:308.
35. Meyer zum Buschenfelde, C., S. Cramer, B. Fleischer, and S. Frosch. 1998. Resistance to Trypanosoma cruzi infection in mice does not necessarily correlate with production of interferon-γ in vivo. Med. Mi crobiol. Immunol. 187:107.
36. Rodriguez, A. M., F. Santoro, D. Afchain, H. Bazin, and H. Capron. 1981. Trypanosoma cruzi infection in B-cell deficient rats. Parasite Immunol. 31:524.
37. Trischmann, T. M. 1983. Non-antibody mediated control of parasitemia in acute experimental Chagas' disease. J. Immunol. 130:1953.
38. Aliberti, J. C., M. A. Cardoso, G. A. Martins, R. T. Gazzinelli, L. Q. Vieira, and J. S. Silva. 1996. Interleukin-12 mediates resistance to Trypanosoma cruzi in mice and is produced by murine macrophages in response to live trypomastigotes. Infect. Immun. 64:1961.
39. Humphrey, J. S., T. S. McCormick, and E. C. Rowland. 1997. Parasite antigen-induced IFN-γ and IL-4 production by cells from pathopermissive and pathoresistant strains of mice infected with Trypanosoma cruzi. J. Parasitol. 83:533.
40. Sunnemark, D., A. K. Ulfgren, A. Orn, and R. A. Harris. 1996. Cytokine production in hearts of Trypanosoma cruzi-infected CBA mice: do cytokine patterns in chronic stage reflect the establishment of myocardial pathology? Scand. J. Immunol. 44:421.
41. Lopes, M. F., M. P. Nunes, A. Henriques-Pons, N. Giese, H. C. Morse III, W. F. Davidson, T. C. Araujo-Jorge, and G. A. DosReis. 1999. Increased susceptibility of Fas ligand-deficient gld mice to Trypanosoma cruzi infection due to a Th2-biased host immune response. Eur. J. Immunol. 29:81.
42. Minoprio, P. 1991. Chagas' disease: CD5 B-cell-dependent Th2 pathology? Res. Immunol 142:137.
43. Minoprio, P., A. Coutinho, S. Spinella, and J. M. Hontebeyrie. 1991, Xid immunodeficiency imparts increased parasite clearance and resistance to pathology in experimental Chagas' disease. Int. Immunol. 3:427.
44. Hontebeyrie, J. M. 1991. Murine Trypanosoma cruzi infection: a role for TH2 cells in the immunopathology of chronic infection. Res. Immunol. 142:141.
45. Millar, A. E., M. Wleklinski-Lee, and S. J. Kahn. 1999. The surface protein superfamily of Trypanosoma cruzi stimulates a polarized Th1 response that becomes anergic. J. Immunol. 162:6092.
46. Hunter, C. A., L. A. Ellis-Neyes, T. Slifer, S. Kanaly, G. Grunig, M. Fort, D. Rennick, and F. G. Araujo. 1997. IL-10 is required to prevent immune hyperactivity during infection with Trypanosoma cruzi. J. Immunol. 158:3311.
47. Dutra, W. O., K. J. Gollob, J. C. Pinto Dias, G. Gazzinelli, R. Correa Oliveira, R. L. Coffman, and J. F. Carvalho Parra. 1997. Cytokine mRNA profile of peripheral blood mononuclear cells isolated from individuals with Trypanosoma cruzi chronic infection. Scand. J. Immunol. 45:74.
48. + in chronic human chagasic myocarditis: correlation with the presence of myocardial Trypanosoma cruzi antigens. Clin. Immunol. Immunopathol. 83:165.
49. Samudio, M., S. Montenegro-James, M. de Cabral, J. Martinez, A. Rojas de Arias, O. Woroniecky, and M. A. James. 1998. Differencial expression of systemic cytokine profiles in Chagas' disease is associated with endemicity of Trypanosoma cruzi infections. Acta Trop. 69:89.