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Volumn 67, Issue 8, 1999, Pages 3855-3863

Predominance of CD4 Th1 and CD8 Tc1 cells revealed by characterization of the cellular immune response generated by immunization with a DNA vaccine containing a Trypanosoma cruzi gene

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; DNA VACCINE;

EID: 0032783138     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.67.8.3855-3863.1999     Document Type: Article
Times cited : (68)

References (52)
  • 1
    • 0029098304 scopus 로고
    • Cytokine and nitric oxide regulation of immunosuppression in Trypanosoma cruzi infection
    • Abrahamsohn, I. A., and R. L. Coffman. 1995. Cytokine and nitric oxide regulation of immunosuppression in Trypanosoma cruzi infection. J. Immunol. 155:3955-3963.
    • (1995) J. Immunol. , vol.155 , pp. 3955-3963
    • Abrahamsohn, I.A.1    Coffman, R.L.2
  • 3
    • 0031965025 scopus 로고    scopus 로고
    • Identification and characterization of protective T cells in hsp65 DNA-vaccinated and Mycobacterium tuberculosu-infected mice
    • Bonato, V. L. D., V. M. F. Lima, R. E. Tascon, D. B. Lowrie, and C. L. Silva. 1998. Identification and characterization of protective T cells in hsp65 DNA-vaccinated and Mycobacterium tuberculosu-infected mice. Infect. Immun. 66:169-175.
    • (1998) Infect. Immun. , vol.66 , pp. 169-175
    • Bonato, V.L.D.1    Lima, V.M.F.2    Tascon, R.E.3    Lowrie, D.B.4    Silva, C.L.5
  • 4
    • 0031953116 scopus 로고    scopus 로고
    • Development of Th1 and Th2 Populations and the nature of immune responses to hepatitis B virus DNA vaccines can be modulated by codelivery of various cytokine genes
    • Chow, Y.-H., B.-L. Chiang, Y.-L. Lee, W.-K. Chi, W.-C. Liu, Y.-T. Chen, and M.-H. Tao. 1998. Development of Th1 and Th2 Populations and the nature of immune responses to hepatitis B virus DNA vaccines can be modulated by codelivery of various cytokine genes. J. Immunol. 160:1320-1329.
    • (1998) J. Immunol. , vol.160 , pp. 1320-1329
    • Chow, Y.-H.1    Chiang, B.-L.2    Lee, Y.-L.3    Chi, W.-K.4    Liu, W.-C.5    Chen, Y.-T.6    Tao, M.-H.7
  • 5
    • 0030613651 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity
    • Chu, R. S., O. S. Targoni, A. M. Krieg, P. V. Lehmann, and C. V. Harding. 1997. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity. J. Exp. Med. 186:1623-1631.
    • (1997) J. Exp. Med. , vol.186 , pp. 1623-1631
    • Chu, R.S.1    Targoni, O.S.2    Krieg, A.M.3    Lehmann, P.V.4    Harding, C.V.5
  • 6
    • 0032077290 scopus 로고    scopus 로고
    • Immunization with a plasmid DNA containing the gene of trans-sialidase reduces Trypanosoma cruzi infection in mice
    • Costa, F., G. Franchin, V. L. Pereira-Chioccola, M. Ribeirão, S. Schenkman, and M. M. Rodrigues. 1998. Immunization with a plasmid DNA containing the gene of trans-sialidase reduces Trypanosoma cruzi infection in mice. Vaccine 16:768-774.
    • (1998) Vaccine , vol.16 , pp. 768-774
    • Costa, F.1    Franchin, G.2    Pereira-Chioccola, V.L.3    Ribeirão, M.4    Schenkman, S.5    Rodrigues, M.M.6
  • 7
    • 0027426946 scopus 로고
    • The surface trans-sialidase family of Trypanosoma cruzi
    • Cross, G. A. M., and G. B. Tackle. 1993. The surface trans-sialidase family of Trypanosoma cruzi. Annu. Rev. Microbiol. 46:383-411.
    • (1993) Annu. Rev. Microbiol. , vol.46 , pp. 383-411
    • Cross, G.A.M.1    Tackle, G.B.2
  • 8
    • 0031964257 scopus 로고    scopus 로고
    • CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen
    • Davis, H. L., R. Weerantsa, T. J. Waldschmidt, L. Tygrett, J. Schorr, and A. M. Krieg. 1998. CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen. J. Immunol. 160:870-876.
    • (1998) J. Immunol. , vol.160 , pp. 870-876
    • Davis, H.L.1    Weerantsa, R.2    Waldschmidt, T.J.3    Tygrett, L.4    Schorr, J.5    Krieg, A.M.6
  • 11
    • 0030745157 scopus 로고    scopus 로고
    • Cell-mediated immunity in experimental Trypanosoma cruzi infection
    • Dos Reis, G. A. 1997. Cell-mediated immunity in experimental Trypanosoma cruzi infection. Parasitol. Today 13:335-342.
    • (1997) Parasitol. Today , vol.13 , pp. 335-342
    • Dos Reis, G.A.1
  • 12
    • 0025740521 scopus 로고
    • Identification of naturally processed viral nonapeptide allows their quantification in infected cells and suggests an allele-specific T cell epitope forecast
    • Falk, K., O. Rötzschke, K. Ores, J. Metzger, G. Jung, and H.-G. Rammensee. 1991. Identification of naturally processed viral nonapeptide allows their quantification in infected cells and suggests an allele-specific T cell epitope forecast. J. Exp. Med. 174:425-434.
    • (1991) J. Exp. Med. , vol.174 , pp. 425-434
    • Falk, K.1    Rötzschke, O.2    Ores, K.3    Metzger, J.4    Jung, G.5    Rammensee, H.-G.6
  • 13
    • 0029987839 scopus 로고    scopus 로고
    • The instructive role of innate immunity in acquired immune response
    • Fearon, D. T., and R. M. Locksley. 1996. The instructive role of innate immunity in acquired immune response. Science 272:50-53.
    • (1996) Science , vol.272 , pp. 50-53
    • Fearon, D.T.1    Locksley, R.M.2
  • 14
    • 0031093543 scopus 로고    scopus 로고
    • Different T helper cell types and antibody isotypes generated by saline and gene gun DNA immunization
    • Feltquate, D. M., S. Heaney, R. G. Webster, and H. L. Robinson. 1997. Different T helper cell types and antibody isotypes generated by saline and gene gun DNA immunization. J. Immunol. 158:2278-2284.
    • (1997) J. Immunol. , vol.158 , pp. 2278-2284
    • Feltquate, D.M.1    Heaney, S.2    Webster, R.G.3    Robinson, H.L.4
  • 15
    • 0030822043 scopus 로고    scopus 로고
    • Vaccination with DNA encoding the immunodominant LACK parasite antigen confers protective immunity to mice infected with Leishmania major
    • Grunathan, S., D. L. Sacks, D. R. Brown, S. L. Reiner, H. Charest, N. Glaichenhaus, and R. A. Seder. 1997. Vaccination with DNA encoding the immunodominant LACK parasite antigen confers protective immunity to mice infected with Leishmania major. J. Exp. Med. 186:1137-1147.
    • (1997) J. Exp. Med. , vol.186 , pp. 1137-1147
    • Grunathan, S.1    Sacks, D.L.2    Brown, D.R.3    Reiner, S.L.4    Charest, H.5    Glaichenhaus, N.6    Seder, R.A.7
  • 16
    • 0000496002 scopus 로고
    • Correlation between Trypanosoma cruzi parasitism and myocardial inflammatory infiltrate in human chronic Chagas' disease and chagasic myocarditis: Light microscopy and immunohistochemical findings
    • Higuchi, M., T. de Brito, M. Reis, A. Barbosa, G. Belloti, A. Pereira-Barreto, and F. Pileggi. 1993. Correlation between Trypanosoma cruzi parasitism and myocardial inflammatory infiltrate in human chronic Chagas' disease and chagasic myocarditis: light microscopy and immunohistochemical findings. Cardiovasc. Pathol. 2:101-104.
    • (1993) Cardiovasc. Pathol. , vol.2 , pp. 101-104
    • Higuchi, M.1    De Brito, T.2    Reis, M.3    Barbosa, A.4    Belloti, G.5    Pereira-Barreto, A.6    Pileggi, F.7
  • 17
    • 0031913243 scopus 로고    scopus 로고
    • Defective nitric oxide effector function lead to extreme susceptibility of Trypanosoma cruzi-infected mice deficient in gamma interferon receptor or inducible nitric oxide synthase
    • Hölscher, C., G. Kölher, U. Müller, H. Mossman, G. A. Schaub, and F. Brombacher. 1998. Defective nitric oxide effector function lead to extreme susceptibility of Trypanosoma cruzi-infected mice deficient in gamma interferon receptor or inducible nitric oxide synthase. Infect. Immun. 66:1208-1215.
    • (1998) Infect. Immun. , vol.66 , pp. 1208-1215
    • Hölscher, C.1    Kölher, G.2    Müller, U.3    Mossman, H.4    Schaub, G.A.5    Brombacher, F.6
  • 19
    • 0032531036 scopus 로고    scopus 로고
    • Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides: A role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA
    • Jakob, T., P, S. Walker, A. M. Krieg, M. C. Udey, and J. C. Vogel. 1998. Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides: a role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA. J. Immunol. 161:3042-3049.
    • (1998) J. Immunol. , vol.161 , pp. 3042-3049
    • Jakob, T.1    Walker, P.S.2    Krieg, A.M.3    Udey, M.C.4    Vogel, J.C.5
  • 20
    • 0029984358 scopus 로고    scopus 로고
    • CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin-6, interleukin-12, and interferon-γ
    • Klinman, D. M., A.-K. Yi, S. L. Beacauge, J, Conover, and A. M. Krieg. 1996. CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin-6, interleukin-12, and interferon-γ. Proc. Nat. Acad. Sci. USA 93:2879-2883.
    • (1996) Proc. Nat. Acad. Sci. USA , vol.93 , pp. 2879-2883
    • Klinman, D.M.1    Yi, A.-K.2    Beacauge, S.L.3    Conover, J.4    Krieg, A.M.5
  • 21
    • 0031569601 scopus 로고    scopus 로고
    • Contribution of CpG motif to the immunogenicity of DNA vaccines
    • Klinman, D. M., G. Yamshchikov, and Y. Ishigaatsubo. 1997. Contribution of CpG motif to the immunogenicity of DNA vaccines. J. Immunol. 158: 3635-3639.
    • (1997) J. Immunol. , vol.158 , pp. 3635-3639
    • Klinman, D.M.1    Yamshchikov, G.2    Ishigaatsubo, Y.3
  • 22
    • 0031215046 scopus 로고    scopus 로고
    • The preferential induction of a Th1 immune response by DNA-based immunization is mediated by immunostimulatory effect of plasmid DNA
    • Leclerc, C., E. Deriaud, M. Rojas, and R. G. Whalen. 1997. The preferential induction of a Th1 immune response by DNA-based immunization is mediated by immunostimulatory effect of plasmid DNA. Cell. Immunol. 179:97-106.
    • (1997) Cell. Immunol. , vol.179 , pp. 97-106
    • Leclerc, C.1    Deriaud, E.2    Rojas, M.3    Whalen, R.G.4
  • 24
    • 0025792001 scopus 로고
    • The JAM test. A simple assay for DNA degradation and cell death
    • Matzinger, P. 1991. The JAM test. A simple assay for DNA degradation and cell death. J. Immunol. Methods 15:185-192.
    • (1991) J. Immunol. Methods , vol.15 , pp. 185-192
    • Matzinger, P.1
  • 25
    • 0029157095 scopus 로고
    • Complexity of the cytokine and antibody response elicited by immunization mice with Plasmodium yoelii circumsporoite protein plasmid DNA
    • Mor, G., D. M. Klinman, S. Shapiro, E. Hagiwara, M. Sedegah, J. A. Norman, S. L. Hoffman, and A. D. Steinberg. 1995. Complexity of the cytokine and antibody response elicited by immunization mice with Plasmodium yoelii circumsporoite protein plasmid DNA. J. Immunol. 155:2039-2046.
    • (1995) J. Immunol. , vol.155 , pp. 2039-2046
    • Mor, G.1    Klinman, D.M.2    Shapiro, S.3    Hagiwara, E.4    Sedegah, M.5    Norman, J.A.6    Hoffman, S.L.7    Steinberg, A.D.8
  • 26
    • 0026500671 scopus 로고
    • Synergism between tumor necrosis factor-alpha and interferon-gamma on macrophage activation for the killing of intracellular Trypanosoma cruzi through a nitric oxide-dependent mechanism
    • Munoz-Fernandez, M. A., M. A. Fernandez, and M. Fresno. 1992. Synergism between tumor necrosis factor-alpha and interferon-gamma on macrophage activation for the killing of intracellular Trypanosoma cruzi through a nitric oxide-dependent mechanism. Eur. J. Immunol. 22:301-307.
    • (1992) Eur. J. Immunol. , vol.22 , pp. 301-307
    • Munoz-Fernandez, M.A.1    Fernandez, M.A.2    Fresno, M.3
  • 27
    • 0027265306 scopus 로고
    • + T-cell clones: T helper type 1-like phenotype and reactivity with shed trypomastigote antigens
    • + T-cell clones: T helper type 1-like phenotype and reactivity with shed trypomastigote antigens. Infect. Immun. 61:3250-3258.
    • (1993) Infect. Immun. , vol.61 , pp. 3250-3258
    • Nickell, S.P.1    Keane, M.2    So, M.3
  • 28
  • 29
    • 0023770735 scopus 로고
    • In vivo administration of IFN-γ induces macrophage activation, and prevents acute disease, immune suppression, and death in experimental Trypanosoma cruzi infection
    • Reed, S. G. 1988. In vivo administration of IFN-γ induces macrophage activation, and prevents acute disease, immune suppression, and death in experimental Trypanosoma cruzi infection. J. Immunol. 140:4342-4347.
    • (1988) J. Immunol. , vol.140 , pp. 4342-4347
    • Reed, S.G.1
  • 30
    • 85083123575 scopus 로고    scopus 로고
    • Unpublished observations
    • 29a.Ribeirao, M. Unpublished observations.
    • Ribeirao, M.1
  • 31
    • 0031440882 scopus 로고    scopus 로고
    • Temperature differences for trans-glycosylation and hydrolysis reaction reveal an acceptor binding site in the catalytic mechanism of Trypanosoma cruzi trans-sialidase
    • Ribeirāo, M., V. L. Pereira-Chioccola, D. Eichinger, M. M. Rodrigues, and S. Schenkman. 1997. Temperature differences for trans-glycosylation and hydrolysis reaction reveal an acceptor binding site in the catalytic mechanism of Trypanosoma cruzi trans-sialidase. Glycobiology 7:1237-1246.
    • (1997) Glycobiology , vol.7 , pp. 1237-1246
    • Ribeirao, M.1    Pereira-Chioccola, V.L.2    Eichinger, D.3    Rodrigues, M.M.4    Schenkman, S.5
  • 33
    • 0026521962 scopus 로고
    • In vivo cytotoxic activity of CD8+ T cell clones correlates with their level of expression of adhesion molecules
    • Rodrigues, M., R. S. Nussenzweig, P. Romero, and F. Zavala. 1992. In vivo cytotoxic activity of CD8+ T cell clones correlates with their level of expression of adhesion molecules. J. Exp. Med. 175:895-905.
    • (1992) J. Exp. Med. , vol.175 , pp. 895-905
    • Rodrigues, M.1    Nussenzweig, R.S.2    Romero, P.3    Zavala, F.4
  • 36
    • 0027496343 scopus 로고
    • Differential susceptibilities of mice genomically deleted of CD4 and CD8 to infections with Trypanosoma cruzi or Trypanosoma brucei
    • Rottenberg, M. E., M. Bakhiet, T. Olsson, K. Kristensson, T. Mak, H. Wigzell, and A. Orn. 1993. Differential susceptibilities of mice genomically deleted of CD4 and CD8 to infections with Trypanosoma cruzi or Trypanosoma brucei. Infect. Immun. 61:5129-5133.
    • (1993) Infect. Immun. , vol.61 , pp. 5129-5133
    • Rottenberg, M.E.1    Bakhiet, M.2    Olsson, T.3    Kristensson, K.4    Mak, T.5    Wigzell, H.6    Orn, A.7
  • 38
    • 0031890359 scopus 로고    scopus 로고
    • Follow-up of 18 patients with human immunodeficiency virus infection and chronic Chagas' disease, with reactivation of Chagas' disease in three patients
    • Sartori, A. M., M. A. Shikanai-Yasuda, V. A. Neto, and M. H. Lopes. 1998. Follow-up of 18 patients with human immunodeficiency virus infection and chronic Chagas' disease, with reactivation of Chagas' disease in three patients. Clin. Infect. Dis. 26:177-179.
    • (1998) Clin. Infect. Dis. , vol.26 , pp. 177-179
    • Sartori, A.M.1    Shikanai-Yasuda, M.A.2    Neto, V.A.3    Lopes, M.H.4
  • 40
    • 0025769326 scopus 로고
    • A novel cell surface trans-sialidase of Trypanosoma cruzi generates a stage-specific epitope required for invasion of mammalian cells
    • Schenkman, S., J. Man-Shiow, G. W. Hart, and V. Nussenzweig. 1991. A novel cell surface trans-sialidase of Trypanosoma cruzi generates a stage-specific epitope required for invasion of mammalian cells. Cell 65:1117-1125.
    • (1991) Cell , vol.65 , pp. 1117-1125
    • Schenkman, S.1    Man-Shiow, J.2    Hart, G.W.3    Nussenzweig, V.4
  • 41
    • 0028807425 scopus 로고
    • Tumor necrosis factor alpha mediates resistance to Trypanosoma cruzi infection in mice by inducing nitric oxide production in infected gamma interferon-activated macrophages
    • Silva, J. S., G. N. R. Vespa, M. A. G. Cardoso, J. C. S. Aliberti, and F. Q. Cunha. 1995. Tumor necrosis factor alpha mediates resistance to Trypanosoma cruzi infection in mice by inducing nitric oxide production in infected gamma interferon-activated macrophages. Infect. Immun. 63:4862-4867.
    • (1995) Infect. Immun. , vol.63 , pp. 4862-4867
    • Silva, J.S.1    Vespa, G.N.R.2    Cardoso, M.A.G.3    Aliberti, J.C.S.4    Cunha, F.Q.5
  • 43
    • 0028873329 scopus 로고
    • The role of T cells in Trypanosoma cruzi infections
    • Tarleton, R. L. 1995. The role of T cells in Trypanosoma cruzi infections. Parasitol. Today 11:7-12.
    • (1995) Parasitol. Today , vol.11 , pp. 7-12
    • Tarleton, R.L.1
  • 44
    • 0030051238 scopus 로고    scopus 로고
    • Trypanosoma cruzi infection in MHC-deficient mice: Further evidence for the role of both class I- and class II-restricted T cells in immune resistance and disease
    • Tarleton, R. L., J. Sun, L. Zhang, M. Postan, and L. Glimcher. 1996. Trypanosoma cruzi infection in MHC-deficient mice: further evidence for the role of both class I- and class II-restricted T cells in immune resistance and disease. Int. Immunol. 8:13-22.
    • (1996) Int. Immunol. , vol.8 , pp. 13-22
    • Tarleton, R.L.1    Sun, J.2    Zhang, L.3    Postan, M.4    Glimcher, L.5
  • 45
    • 0028043326 scopus 로고
    • IL-12: A cytokine produced by antigen-presenting cells with immunoregulatory function in the generation of T-helper cell type 1 and cytotoxic lymphocytes
    • Trinchieri, G. 1994. IL-12: a cytokine produced by antigen-presenting cells with immunoregulatory function in the generation of T-helper cell type 1 and cytotoxic lymphocytes. Blood 84:4008-4027.
    • (1994) Blood , vol.84 , pp. 4008-4027
    • Trinchieri, G.1
  • 46
    • 0026744786 scopus 로고
    • Only some members of a gene family in Trypanosoma cruzi encode proteins that express both trans-sialidase and neuraminidase activities
    • Uemura, H., S. Schenkman, V. Nussenzweig, and D. Eichinger. 1992. Only some members of a gene family in Trypanosoma cruzi encode proteins that express both trans-sialidase and neuraminidase activities. EMBO J. 11:3837-3844.
    • (1992) EMBO J. , vol.11 , pp. 3837-3844
    • Uemura, H.1    Schenkman, S.2    Nussenzweig, V.3    Eichinger, D.4
  • 49
    • 0027955005 scopus 로고
    • Treatment of chronic Chagas' disease with benznidazole: Clinical and serologic evolution of patients with long-term follow up
    • Viotti, R., C. Vigliano, H. Armenti, and E. Segura. 1994. Treatment of chronic Chagas' disease with benznidazole: clinical and serologic evolution of patients with long-term follow up. Am. Heart J. 127:151-162.
    • (1994) Am. Heart J. , vol.127 , pp. 151-162
    • Viotti, R.1    Vigliano, C.2    Armenti, H.3    Segura, E.4
  • 50
    • 0031573518 scopus 로고    scopus 로고
    • Identification of Trypanosoma cruzi trans-sialidase family members as targets of protective CD8+ TC1 responses
    • Wizel, B., M. Nunes, and R. Tarleton. 1997. Identification of Trypanosoma cruzi trans-sialidase family members as targets of protective CD8+ TC1 responses. J. Immunol. 159:6120-6130.
    • (1997) J. Immunol. , vol.159 , pp. 6120-6130
    • Wizel, B.1    Nunes, M.2    Tarleton, R.3
  • 51
    • 0032425402 scopus 로고    scopus 로고
    • Vaccination with trypomastigote surface antigen 1-encoding plasmid DNA confers protection against lethal Trypanosoma cruzi infection
    • Wizel, B., N. Garg, and R. Tarleton. 1998. Vaccination with trypomastigote surface antigen 1-encoding plasmid DNA confers protection against lethal Trypanosoma cruzi infection. Infect. Immun. 66:5073-5081.
    • (1998) Infect. Immun. , vol.66 , pp. 5073-5081
    • Wizel, B.1    Garg, N.2    Tarleton, R.3
  • 52
    • 0031570510 scopus 로고    scopus 로고
    • Functions and specificity of T cells following nucleic acid vaccination of mice against Mycobacterium tuberculosis infection
    • Zhu, X., N. Venkaprasad, H. S. Thangaraj, M. Hill, M. Singh, J. Ivanyi, and H. M. Vordermeier. 1997. Functions and specificity of T cells following nucleic acid vaccination of mice against Mycobacterium tuberculosis infection. J. Immunol. 158:5921-5926.
    • (1997) J. Immunol. , vol.158 , pp. 5921-5926
    • Zhu, X.1    Venkaprasad, N.2    Thangaraj, H.S.3    Hill, M.4    Singh, M.5    Ivanyi, J.6    Vordermeier, H.M.7


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