Immune response to a major Trypanosoma cruzi antigen, cruzipain, is differentially modulated in C57BL/6 and BALB/c mice

Microbes and Infection

Volumn 6, Issue 14, 2004, Pages 1250-1258

  Guiñazú, Natalia ^a   Pellegrini, Andrea ^a   Giordanengo, Laura ^a   Aoki, Maria P ^a   Rivarola, Hector W ^b   Cano, Roxana ^a   Rodrigues, Mauricio M ^c   Gea, Susana ^a  

^a Fac Cie Quimicas Univ Nac C   (Argentina)

^b Univ Nac Cordoba Cordoba A

^c Depto de Cie Farmaceuticas   (Brazil)

Author keywords

Cytokines; GATA 3; Parasite; Th1 Th2 cells; Trans sialidase

Indexed keywords

CARDIAC MYOSIN; CD11B ANTIGEN; CD19 ANTIGEN; CD4 ANTIGEN; CRUZIPAIN; GAMMA INTERFERON; INTERLEUKIN 4; TRANSFORMING GROWTH FACTOR BETA;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CELL COUNT; CELL STIMULATION; CONTROLLED STUDY; FEMALE; IMMUNE RESPONSE; IMMUNIZATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SPLEEN CELL; STATISTICAL SIGNIFICANCE; TH1 CELL; TRYPANOSOMA CRUZI;

ANIMALS; ANTIBODIES, PROTOZOAN; ANTIGENS, CD19; ANTIGENS, CD4; ANTIGENS, PROTOZOAN; AUTOIMMUNITY; CYSTEINE ENDOPEPTIDASES; DNA-BINDING PROTEINS; GATA3 TRANSCRIPTION FACTOR; HYPERSENSITIVITY, DELAYED; HYPERSENSITIVITY, IMMEDIATE; INTERFERON TYPE II; INTERLEUKIN-4; LYMPHOCYTE SUBSETS; LYMPHOCYTES; MACROPHAGE-1 ANTIGEN; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MYOCARDIUM; MYOSINS; SPLEEN; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA; TRYPANOSOMA CRUZI;

TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 9144241840     PISSN: 12864579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.micinf.2004.07.010     Document Type: Article

References (32)

1. A. Moncayo Progress towards interruption of transmission of Chagas' disease Mem. Inst. Oswaldo Cruz 94 1999 401 404
2. M.M. Teixeira, R.T. Gazzinelli, and J.S. Silva Chemokines, inflammation and Trypanosoma cruzi infection Trends Parasitol. 18 2002 262 265
3. D.M. Engman, and J.S. Leon Pathogenesis of Chagas' heart disease: role of autoimmunity Acta Trop. 81 2002 123 132
4. F. Kierszenbaum Chagas' disease and the autoimmunity hypothesis Clin. Microbiol. Rev. 12 1999 210 223
5. N. Girones, and M. Fresno Etiology of Chagas' disease myocarditis: autoimmunity, parasite persistence, or both? Trends Parasitol. 19 2003 19 22
6. S. Gea, A. Gruppi, B. Basso, E. Menso, and E. Vottero-Cima Antibodies to Trypanosoma cruzi cytosol acidic antigens (FIV) in Chagas' disease recognize parasite cell surface and human heart epitopes J. Clin. Lab. Immunol. 31 1990 183 187
7. E. Cunha-Neto, V. Coelho, L. Guilherme, A. Fiorelli, N. Stolf, and J. Kalil Autoimmunity in Chagas' disease. Identification of cardiac myosin-B13 Trypanosoma cruzi protein crossreactive T-cell clones in heart lesions of a chronic Chagas' cardiomyopathy patient J. Clin. Invest. 98 1996 1709 1712
8. E. Cunha-Neto, M. Duranti, A. Gruber, B. Zingales, I. De Messias, and N. Stolf Autoimmunity in Chagas' disease cardiopathy: biological relevance of a cardiac myosin-specific epitope crossreactive to an immunodominant Trypanosoma cruzi antigen Proc. Natl. Acad. Sci. USA 92 1995 3541 3545
9. N. Girones, C.I. Rodriguez, B. Basso, J.M. Bellon, S. Resino, M.A. Munoz-Fernandez, S. Gea, E. Moretti, and M. Fresno Antibodies to an epitope from the Cha human autoantigen are markers of Chagas' disease Clin. Diagn. Lab. Immunol. 8 2001 1039 1043
10. J.J. Cazzulo, M.C. Cazzulo Franke, J. Martinez, and B.M. Franke de Cazzulo Some kinetic properties of a cysteine proteinase (cruzipain) from Trypanosoma cruzi Biochim. Biophys. Acta 1037 1990 186 191
11. A.C. Arnholdt, M.R. Piuvezam, D.M. Russo, A.P. Lima, R.C. Pedrosa, and S.G. Reed Analysis and partial epitope mapping of human T-cell responses to Trypanosoma cruzi cysteinyl proteinase J. Immunol. 151 1993 3171 3179
12. D. Laderach, F. Cerban, C. Motran, E. Vottero de Cima, and S. Gea Trypanosoma cruzi: the major cysteinyl proteinase (cruzipain) is a relevant immunogen of parasite acidic antigens (FIII) Int. J. Parasitol. 26 1996 1249 1254
13. L. Giordanengo, R. Fretes, H. Diaz, R. Cano, A. Bacile, and E. Vottero-Cima Cruzipain induces autoimmune response against skeletal muscle and tissue damage in mice Muscle Nerve 23 2000 1407 1413
14. L. Giordanengo, C. Maldonado, H.W. Rivarola, D. Iosa, N. Girones, and M. Fresno Induction of antibodies reactive to cardiac myosin and development of heart alterations in cruzipain-immunized mice and their offspring Eur. J. Immunol. 30 2000 3181 3189
15. D.F. Hoft, R.G. Lynch, and L.V. Kirchhoff Kinetic analysis of antigen-specific immune responses in resistant and susceptible mice during infection with Trypanosoma cruzi J. Immunol. 151 1993 7038 7047
16. J.S. Leon, L.M. Godsel, K. Wang, and D.M. Engman Cardiac myosin autoimmunity in acute Chagas' heart disease Infect. Immun. 69 2001 5643 5649
17. M.L. Guler, J.D. Gorham, C.S. Hsieh, A.J. Mackey, R.G. Steen, and W.F. Dietrich Genetic susceptibility to Leishmania: IL-12 responsiveness in Th1 cell development Science 271 1996 984 987
18. J.R. Vasconcelos, S.B. Boscardin, M.I. Hiyane, S.S. Kinoshita, A.E. Fujimura, and M.M. Rodrigues A DNA-priming protein-boosting regimen significantly improves type 1 immuneresponse but not protective immunity to Trypanosoma cruzi infection in a highly susceptible mouse strain Immunol. Cell Biol. 81 2003 121 129
19. U.K. Laemmli Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 227 1970 680 685
20. R.C. Cano, E. Hliba, and E.R. Rubiolo Creatine kinase and lactate dehydrogenase levels as potential indicators of Trypanosoma cruzi infectivity and histotropism in experimental Chagas' disease Parasitol. Res. 86 2000 244 252
21. S. Ranganath, and K.M. Murphy Structure and specificity of GATA proteins in Th2 development Mol. Cell. Biol. 21 2001 2716 2725
22. L. Giordanengo, N. Guiñazu, C. Stempin, R. Fretes, F. Cerban, and S. Gea Cruzipain, a major Trypanosoma cruzi antigen, conditions the host immune response in favor of parasite Eur. J. Immunol. 32 2002 1003 1011
23. R. Bommireddy, V. Saxena, I. Ormsby, M. Yin, G.P. Boivin, G.F. Babcock, R.R. Singh, and T. Doetschman TGF-beta1 regulates lymphocyte homeostasis by preventing activation and subsequent apoptosis of peripheral lymphocytes J. Immunol. 170 2003 4612 4622
24. M.K. Levings, R. Bacchetta, U. Schulz, and M.G. Roncarolo The role of IL-10 and TGF-beta in the differentiation and effector function of T regulatory cells Int. Arch. Allergy Immunol. 129 2002 263 276
25. K.J. Maloy, and F. Powrie Regulatory T cells in the control of immune pathology Nat. Immunol. 2 2001 816 822
26. L. Sterin-Borda, L. Giordanengo, L. Joensen, and S. Gea Cruzipain induces autoantibodies against cardiac muscarinic acetylcholine receptors. Functional and pathological implications Eur. J. Immunol. 33 2003 2459 2648
27. R.M. Martin, J.L. Brady, and A.M. Lew The need for IgG2c specific antiserum when isotyping antibodies from C57BL/6 and NOD mice J. Immunol. Methods 212 1998 187 192
28. V.G. Duschak, A. Riarte, E.L. Segura, and S.A. Laucella Humoral immune response to cruzipain and cardiac dysfunction in chronic Chagas' disease Immunol. Lett. 78 2001 135 142
29. Z. Layrisse, M.T. Fernandez, S. Montagnani, M. Matos, O. Balbas, and F. Herrera HLA-C(*)03 is a risk factor for cardiomyopathy in Chagas' disease Hum. Immunol. 61 2000 925 929
30. A. Nieto, Y. Beraun, M.D. Collado, A. Caballero, A. Alonso, and A. Gonzalez HLA haplotypes are associated with differential susceptibility to Trypanosoma cruzi infection Tissue Antigens 55 2000 195 198
31. S.A. Laucella, M. Postan, D. Martin, B. Hubby Fralish, M.C. Albareda, M.G. Alvarez, B. Lococo, G. Barbieri, R.J. Viotti, and R.L. Tarleton Frequency of interferon-gamma-producing T cells specific for Trypanosoma cruzi inversely correlates with disease severity in chronic human Chagas' disease J. Infect. Dis. 189 2004 909 918
32. P.S. Ohashi T-cell signalling and autoimmunity: molecular mechanisms of disease Nat. Rev. Immunol. 6 2002 427 438