MicroRNAs and vascular (dys)function

Vascular Pharmacology

Volumn 55, Issue 4, 2011, Pages 92-105

  Hartmann, Dorothee ^a   Thum, Thomas ^a,b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b IRCCS SAN RAFFAELE PISANA   (Italy)

Author keywords

Cardiovascular disease; Gene regulation; MiRNA therapeutics; MiRNAs

Indexed keywords

[2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID; MICRORNA; MICRORNA 125A; MICRORNA 125B; MICRORNA 126; MICRORNA 132; MICRORNA 143; MICRORNA 145; MICRORNA 146A; MICRORNA 15A; MICRORNA 17; MICRORNA 21; MICRORNA 210; MICRORNA 217; MICRORNA 218; MICRORNA 221; MICRORNA 222; MICRORNA 23B; MICRORNA 24; MICRORNA 26A; MICRORNA 377; MICRORNA 503; RNA; UNCLASSIFIED DRUG;

ANTIANGIOGENIC ACTIVITY; BLOOD BRAIN BARRIER; CARDIOVASCULAR DISEASE; CARDIOVASCULAR FUNCTION; GENE TARGETING; HUMAN; MEDICAL LITERATURE; MEDICAL RESEARCH; NONHUMAN; PRIORITY JOURNAL; REVIEW; VASCULARIZATION;

ANGIOGENESIS MODULATING AGENTS; ANIMALS; CARDIOVASCULAR DISEASES; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION; HUMANS; MICRORNAS; MOLECULAR TARGETED THERAPY; MUSCLE, SMOOTH, VASCULAR; OLIGORIBONUCLEOTIDES; OLIGORIBONUCLEOTIDES, ANTISENSE;

EID: 82155167635     PISSN: 15371891     EISSN: 18793649     Source Type: Journal    
DOI: 10.1016/j.vph.2011.07.005     Document Type: Review

References (240)

1. Albig A.R., Schiemann W.P. Identification and characterization of regulator of G protein signaling 4 (RGS4) as a novel inhibitor of tubulogenesis: RGS4 inhibits mitogen-activated protein kinases and vascular endothelial growth factor signaling. Mol. Biol. Cell 2005, 16:609-625.
2. Ali S., Ali S. Role of c-kit/SCF in cause and treatment of gastrointestinal stromal tumors (GIST). Gene 2007, 401:38-45.
3. Altuvia Y., Landgraf P., Lithwick G., Elefant N., Pfeffer S., Aravin A., Brownstein M.J., Tuschl T., Margalit H. Clustering and conservation patterns of human microRNAs. Nucleic Acids Res. 2005, 33:2697-2706.
4. Anand S., Majeti B.K., Acevedo L.M., Murphy E.A., Mukthavaram R., Scheppke L., Huang M., Shields D.J., Lindquist J.N., Lapinski P.E., King P.D., Weis S.M., Cheresh D.A. MicroRNA-132-mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis. Nat. Med. 2010, 16:909-914.
5. Barkalow K.L., Italiano J.E., Chou D.E., Matsuoka Y., Bennett V., Hartwig J.H. Alpha-adducin dissociates from F-actin and spectrin during platelet activation. J. Cell Biol. 2003, 161:557-570.
6. Bartel D.P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004, 116:281-297.
7. Barton M., Haudenschild C.C., d'Uscio L.V., Shaw S., Munter K., Luscher T.F. Endothelin ETA receptor blockade restores NO-mediated endothelial function and inhibits atherosclerosis in apolipoprotein E-deficient mice. Proc. Natl. Acad. Sci. U.S.A. 1998, 95:14367-14372.
8. Bauersachs J., Thum T. Biogenesis and regulation of cardiovascular MicroRNAs. Circ Res. 2011, 109:334-347.
9. Beckman J.D., Chen C., Nguyen J., Thayanithy V., Subramanian S., Steer C.J., Vercellotti G.M. Regulation of heme oxygenase-1 protein expression by miR-377 in combination with miR-217. J. Biol. Chem. 2011, 286:3194-3202.
10. Bentwich I., Avniel A., Karov Y., Aharonov R., Gilad S., Barad O., Barzilai A., Einat P., Einav U., Meiri E., Sharon E., Spector Y., Bentwich Z. Identification of hundreds of conserved and nonconserved human microRNAs. Nat. Genet. 2005, 37:766-770.
11. Berezikov E., Guryev V., van de Belt J., Wienholds E., Plasterk R.H., Cuppen E. Phylogenetic shadowing and computational identification of human microRNA genes. Cell 2005, 120:21-24.
12. Boger R.H., Bode-Boger S.M., Szuba A., Tsao P.S., Chan J.R., Tangphao O., Blaschke T.F., Cooke J.P. Asymmetric dimethylarginine (ADMA): a novel risk factor for endothelial dysfunction: its role in hypercholesterolemia. Circulation 1998, 98:1842-1847.
13. Bohnsack M.T., Czaplinski K., Gorlich D. Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs. RNA 2004, 10:185-191.
14. Bonauer A., Carmona G., Iwasaki M., Mione M., Koyanagi M., Fischer A., Burchfield J., Fox H., Doebele C., Ohtani K., Chavakis E., Potente M., Tjwa M., Urbich C., Zeiher A.M., Dimmeler S. MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice. Science 2009, 324:1710-1713.
15. Bonauer A., Boon R.A., Dimmeler S. Vascular microRNAs. Curr. Drug Targets 2010, 11:943-949.
16. Bordet R., Ouk T., Petrault O., Gele P., Gautier S., Laprais M., Deplanque D., Duriez P., Staels B., Fruchart J.C., Bastide M. PPAR: a new pharmacological target for neuroprotection in stroke and neurodegenerative diseases. Biochem. Soc. Trans. 2006, 34:1341-1346.
17. Boulanger C.M., Tanner F.C., Bea M.L., Hahn A.W., Werner A., Luscher T.F. Oxidized low density lipoproteins induce mRNA expression and release of endothelin from human and porcine endothelium. Circ. Res. 1992, 70:1191-1197.
18. Brose K., Bland K.S., Wang K.H., Arnott D., Henzel W., Goodman C.S., Tessier-Lavigne M., Kidd T. Slit proteins bind robo receptors and have an evolutionarily conserved role in repulsive axon guidance. Cell 1999, 96:795-806.
19. Buchdunger E., Zimmermann J., Mett H., Meyer T., Muller M., Druker B.J., Lydon N.B. Inhibition of the abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative. Cancer Res. 1996, 56:100-104.
20. Cai X. Regulation of smooth muscle cells in development and vascular disease: current therapeutic strategies. Expert. Rev. Cardiovasc. Ther. 2006, 4:789-800.
21. Calin G.A., Croce C.M. MicroRNA signatures in human cancers. Nat. Rev. Cancer. 2006, 6:857-866.
22. Calin G.A., Sevignani C., Dumitru C.D., Hyslop T., Noch E., Yendamuri S., Shimizu M., Rattan S., Bullrich F., Negrini M., Croce C.M. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:2999-3004.
23. Callis T.E., Chen J.F., Wang D.Z. MicroRNAs in skeletal and cardiac muscle development. DNA Cell Biol. 2007, 26:219-225.
24. Campagnolo L., Leahy A., Chitnis S., Koschnick S., Fitch M.J., Fallon J.T., Loskutoff D., Taubman M.B., Stuhlmann H. EGFL7 is a chemoattractant for endothelial cells and is up-regulated in angiogenesis and arterial injury. Am. J. Pathol. 2005, 167:275-284.
25. Caporali A., Meloni M., Vollenkle C., Bonci D., Sala-Newby G.B., Addis R., Spinetti G., Losa S., Masson R., Baker A.H., Agami R., le Sage C., Condorelli G., Madeddu P., Martelli F., Emanueli C. Deregulation of microRNA-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after limb ischemia. Circulation 2011, 123:282-291.
26. Carmeliet P. VEGF as a key mediator of angiogenesis in cancer. Oncology 2005, 69(Suppl. 3):4-10.
27. Carmeliet P., Tessier-Lavigne M. Common mechanisms of nerve and blood vessel wiring. Nature 2005, 436:193-200.
28. Chan M.C., Hilyard A.C., Wu C., Davis B.N., Hill N.S., Lal A., Lieberman J., Lagna G., Hata A. Molecular basis for antagonism between PDGF and the TGFbeta family of signalling pathways by control of miR-24 expression. EMBO J. 2010, 29:559-573.
29. Chen Y.E., Fu M., Zhang J., Zhu X., Lin Y., Akinbami M.A., Song Q. Peroxisome proliferator-activated receptors and the cardiovascular system. Vitam. Horm. 2003, 66:157-188.
30. Chen J.F., Mandel E.M., Thomson J.M., Wu Q., Callis T.E., Hammond S.M., Conlon F.L., Wang D.Z. The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation. Nat. Genet. 2006, 38:228-233.
31. Chen Y., Leal A.D., Patel S., Gorski D.H. The homeobox gene GAX activates p21WAF1/CIP1 expression in vascular endothelial cells through direct interaction with upstream AT-rich sequences. J. Biol. Chem. 2007, 282:507-517.
32. Chen Y., Banda M., Speyer C.L., Smith J.S., Rabson A.B., Gorski D.H. Regulation of the expression and activity of the antiangiogenic homeobox gene GAX/MEOX2 by ZEB2 and microRNA-221. Mol. Cell. Biol. 2010, 30:3902-3913.
33. Cheng Y., Ji R., Yue J., Yang J., Liu X., Chen H., Dean D.B., Zhang C. MicroRNAs are aberrantly expressed in hypertrophic heart: do they play a role in cardiac hypertrophy?. Am. J. Pathol. 2007, 170:1831-1840.
34. Cheng Y., Liu X., Yang J., Lin Y., Xu D.Z., Lu Q., Deitch E.A., Huo Y., Delphin E.S., Zhang C. MicroRNA-145, a novel smooth muscle cell phenotypic marker and modulator, controls vascular neointimal lesion formation. Circ. Res. 2009, 105:158-166.
35. Cheng Y., Liu X., Zhang S., Lin Y., Yang J., Zhang C. MicroRNA-21 protects against the H(2)O(2)-induced injury on cardiac myocytes via its target gene PDCD4. J. Mol. Cell. Cardiol. 2009, 47:5-14.
36. Chien S. Mechanical and chemical regulation of endothelial cell polarity. Circ. Res. 2006, 98:863-865.
37. Cho H., Kozasa T., Bondjers C., Betsholtz C., Kehrl J.H. Pericyte-specific expression of Rgs5: implications for PDGF and EDG receptor signaling during vascular maturation. FASEB J. 2003, 17:440-442.
38. Cho W.C., Chow A.S., Au J.S. Restoration of tumour suppressor hsa-miR-145 inhibits cancer cell growth in lung adenocarcinoma patients with epidermal growth factor receptor mutation. Eur. J. Cancer 2009, 45:2197-2206.
39. Church J.E., Qian J., Kumar S., Black S.M., Venema R.C., Papapetropoulos A., Fulton D.J. Inhibition of endothelial nitric oxide synthase by the lipid phosphatase PTEN. Vascul Pharmacol. 2010, 52:191-198.
40. Cimmino A., Calin G.A., Fabbri M., Iorio M.V., Ferracin M., Shimizu M., Wojcik S.E., Aqeilan R.I., Zupo S., Dono M., Rassenti L., Alder H., Volinia S., Liu C.G., Kipps T.J., Negrini M., Croce C.M. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:13944-13949.
41. Cordes K.R., Sheehy N.T., White M.P., Berry E.C., Morton S.U., Muth A.N., Lee T.H., Miano J.M., Ivey K.N., Srivastava D. miR-145 and miR-143 regulate smooth muscle cell fate and plasticity. Nature 2009, 460:705-710.
42. Dang D.T., Zhao W., Mahatan C.S., Geiman D.E., Yang V.W. Opposing effects of kruppel-like factor 4 (gut-enriched kruppel-like factor) and kruppel-like factor 5 (intestinal-enriched kruppel-like factor) on the promoter of the kruppel-like factor 4 gene. Nucleic Acids Res. 2002, 30:2736-2741.
43. Davis B.N., Hilyard A.C., Nguyen P.H., Lagna G., Hata A. Induction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotype. J. Biol. Chem. 2009, 284:3728-3738.
44. Dentelli P., Rosso A., Orso F., Olgasi C., Taverna D., Brizzi M.F. microRNA-222 controls neovascularization by regulating signal transducer and activator of transcription 5A expression. Arterioscler. Thromb. Vasc. Biol. 2010, 30:1562-1568.
45. Dews M., Homayouni A., Yu D., Murphy D., Sevignani C., Wentzel E., Furth E.E., Lee W.M., Enders G.H., Mendell J.T., Thomas-Tikhonenko A. Augmentation of tumor angiogenesis by a myc-activated microRNA cluster. Nat. Genet. 2006, 38:1060-1065.
46. Dews M., Fox J.L., Hultine S., Sundaram P., Wang W., Liu Y.Y., Furth E., Enders G.H., El-Deiry W., Schelter J.M., Cleary M.A., Thomas-Tikhonenko A. The myc-miR-17 92 axis blunts TGF{beta} signaling and production of multiple TGF{beta}-dependent antiangiogenic factors. Cancer Res. 2010, 70:8233-8246.
47. Doebele C., Bonauer A., Fischer A., Scholz A., Reiss Y., Urbich C., Hofmann W.K., Zeiher A.M., Dimmeler S. Members of the microRNA-17-92 cluster exhibit a cell-intrinsic antiangiogenic function in endothelial cells. Blood 2010, 115:4944-4950.
48. Dong S., Cheng Y., Yang J., Li J., Liu X., Wang X., Wang D., Krall T.J., Delphin E.S., Zhang C. MicroRNA expression signature and the role of microRNA-21 in the early phase of acute myocardial infarction. J. Biol. Chem. 2009, 284:29514-29525.
49. Doran A.C., Meller N., McNamara C.A. Role of smooth muscle cells in the initiation and early progression of atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 2008, 28:812-819.
50. Eiseler T., Doppler H., Yan I.K., Kitatani K., Mizuno K., Storz P. Protein kinase D1 regulates cofilin-mediated F-actin reorganization and cell motility through slingshot. Nat. Cell Biol. 2009, 11:545-556.
51. Elia L., Quintavalle M., Zhang J., Contu R., Cossu L., Latronico M.V., Peterson K.L., Indolfi C., Catalucci D., Chen J., Courtneidge S.A., Condorelli G. The knockout of miR-143 and -145 alters smooth muscle cell maintenance and vascular homeostasis in mice: correlates with human disease. Cell Death Differ. 2009, 16:1590-1598.
52. Elmen J., Lindow M., Schutz S., Lawrence M., Petri A., Obad S., Lindholm M., Hedtjarn M., Hansen H.F., Berger U., Gullans S., Kearney P., Sarnow P., Straarup E.M., Kauppinen S. LNA-mediated microRNA silencing in non-human primates. Nature 2008, 452:896-899.
53. Esau C., Kang X., Peralta E., Hanson E., Marcusson E.G., Ravichandran L.V., Sun Y., Koo S., Perera R.J., Jain R., Dean N.M., Freier S.M., Bennett C.F., Lollo B., Griffey R. MicroRNA-143 regulates adipocyte differentiation. J. Biol. Chem. 2004, 279:52361-52365.
54. Esau C., Davis S., Murray S.F., Yu X.X., Pandey S.K., Pear M., Watts L., Booten S.L., Graham M., McKay R., Subramaniam A., Propp S., Lollo B.A., Freier S., Bennett C.F., Bhanot S., Monia B.P. miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting. Cell. Metab. 2006, 3:87-98.
55. Faller M., Matsunaga M., Yin S., Loo J.A., Guo F. Heme is involved in microRNA processing. Nat. Struct. Mol. Biol. 2007, 14:23-29.
56. Fasanaro P., D'Alessandra Y., Di Stefano V., Melchionna R., Romani S., Pompilio G., Capogrossi M.C., Martelli F. MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand ephrin-A3. J. Biol. Chem. 2008, 283:15878-15883.
57. Felli N., Fontana L., Pelosi E., Botta R., Bonci D., Facchiano F., Liuzzi F., Lulli V., Morsilli O., Santoro S., Valtieri M., Calin G.A., Liu C.G., Sorrentino A., Croce C.M., Peschle C. MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:18081-18086.
58. Fichtlscherer S., De Rosa S., Fox H., Schwietz T., Fischer A., Liebetrau C., Weber M., Hamm C.W., Roxe T., Muller-Ardogan M., Bonauer A., Zeiher A.M., Dimmeler S. Circulating microRNAs in patients with coronary artery disease. Circ. Res. 2010, 107:677-684.
59. Fiedler J., Jazbutyte V., Kirchmaier B.C., Gupta S.K., Lorenzen J., Hartmann D., Galuppo P., Kneitz K., Pena J.T.G., Sohn-Lee C., Loyer X., Soutschek J., Brand T., Tuschl T., Heineke J., Martin U., Schulte-Merker S., Ertl G., Engelhardt S., Bauersachs J., Thum T. MicroRNA-24 regulates vascularity after myocardial infarction. Circulation 2011, 124:720-730.
60. Filipowicz W., Bhattacharyya S.N., Sonenberg N. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?. Nat. Rev. Genet. 2008, 9:102-114.
61. Finnerty J.R., Wang W.X., Hebert S.S., Wilfred B.R., Mao G., Nelson P.T. The miR-15/107 group of microRNA genes: evolutionary biology, cellular functions, and roles in human diseases. J. Mol. Biol. 2010, 402:491-509.
62. Fish J.E., Santoro M.M., Morton S.U., Yu S., Yeh R.F., Wythe J.D., Ivey K.N., Bruneau B.G., Stainier D.Y., Srivastava D. miR-126 regulates angiogenic signaling and vascular integrity. Dev. Cell. 2008, 15:272-284.
63. Fitch M.J., Campagnolo L., Kuhnert F., Stuhlmann H. Egfl7, a novel epidermal growth factor-domain gene expressed in endothelial cells. Dev. Dyn. 2004, 230:316-324.
64. Fleissner F., Jazbutyte V., Fiedler J., Gupta S.K., Yin X., Xu Q., Galuppo P., Kneitz S., Mayr M., Ertl G., Bauersachs J., Thum T. Short communication: asymmetric dimethylarginine impairs angiogenic progenitor cell function in patients with coronary artery disease through a microRNA-21-dependent mechanism. Circ. Res. 2010, 107:138-143.
65. Folkman J. The role of angiogenesis in tumor growth. Semin. Cancer Biol. 1992, 3:65-71.
66. Fontana L., Fiori M.E., Albini S., Cifaldi L., Giovinazzi S., Forloni M., Boldrini R., Donfrancesco A., Federici V., Giacomini P., Peschle C., Fruci D. Antagomir-17-5p abolishes the growth of therapy-resistant neuroblastoma through p21 and BIM. PLoS One 2008, 3:e2236.
67. Fornari F., Gramantieri L., Ferracin M., Veronese A., Sabbioni S., Calin G.A., Grazi G.L., Giovannini C., Croce C.M., Bolondi L., Negrini M. MiR-221 controls CDKN1C/p57 and CDKN1B/p27 expression in human hepatocellular carcinoma. Oncogene 2008, 27:5651-5661.
68. Frelin C., Guedin D. Why are circulating concentrations of endothelin-1 so low?. Cardiovasc. Res. 1994, 28:1613-1622.
69. Fujita S., Ito T., Mizutani T., Minoguchi S., Yamamichi N., Sakurai K., Iba H. miR-21 gene expression triggered by AP-1 is sustained through a double-negative feedback mechanism. J. Mol. Biol. 2008, 378:492-504.
70. Galardi S., Mercatelli N., Giorda E., Massalini S., Frajese G.V., Ciafre S.A., Farace M.G. miR-221 and miR-222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1. J. Biol. Chem. 2007, 282:23716-23724.
71. Gardner K., Bennett V. Modulation of spectrin-actin assembly by erythrocyte adducin. Nature 1987, 328:359-362.
72. Giacinti C., Giordano A. RB and cell cycle progression. Oncogene 2006, 25:5220-5227.
73. Gimona M., Kaverina I., Resch G.P., Vignal E., Burgstaller G. Calponin repeats regulate actin filament stability and formation of podosomes in smooth muscle cells. Mol. Biol. Cell 2003, 14:2482-2491.
74. Gitay-Goren H., Soker S., Vlodavsky I., Neufeld G. The binding of vascular endothelial growth factor to its receptors is dependent on cell surface-associated heparin-like molecules. J. Biol. Chem. 1992, 267:6093-6098.
75. Gizard F., Amant C., Barbier O., Bellosta S., Robillard R., Percevault F., Sevestre H., Krimpenfort P., Corsini A., Rochette J., Glineur C., Fruchart J.C., Torpier G., Staels B. PPAR alpha inhibits vascular smooth muscle cell proliferation underlying intimal hyperplasia by inducing the tumor suppressor p16INK4a. J. Clin. Invest. 2005, 115:3228-3238.
76. Grant K., Loizidou M., Taylor I. Endothelin-1: a multifunctional molecule in cancer. Br. J. Cancer 2003, 88:163-166.
77. Gross D.J., Munter G., Bitan M., Siegal T., Gabizon A., Weitzen R., Merimsky O., Ackerstein A., Salmon A., Sella A., Slavin S., Israel Glivec in Solid Tumors Study Group The role of imatinib mesylate (glivec) for treatment of patients with malignant endocrine tumors positive for c-kit or PDGF-R. Endocr. Relat. Cancer 2006, 13:535-540.
78. Gupta S.K., Bang C., Thum T. Circulating microRNAs as biomarkers and potential paracrine mediators of cardiovascular disease. Circ. Cardiovasc. Genet. 2010, 3:484-488.
79. Hamblin M., Chang L., Fan Y., Zhang J., Chen Y.E. PPARs and the cardiovascular system. Antioxid. Redox Signal. 2009, 11:1415-1452.
80. Hammond S.M. RNAi, microRNAs, and human disease. Cancer Chemother. Pharmacol. 2006, 58(Suppl 1):s63-s68.
81. Hammond S.M., Boettcher S., Caudy A.A., Kobayashi R., Hannon G.J. Argonaute2, a link between genetic and biochemical analyses of RNAi. Science 2001, 293:1146-1150.
82. Harris T.A., Yamakuchi M., Ferlito M., Mendell J.T., Lowenstein C.J. MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:1516-1521.
83. Harris T.A., Yamakuchi M., Kondo M., Oettgen P., Lowenstein C.J. Ets-1 and ets-2 regulate the expression of microRNA-126 in endothelial cells. Arterioscler. Thromb. Vasc. Biol. 2010, 30:1990-1997.
84. He L., Thomson J.M., Hemann M.T., Hernando-Monge E., Mu D., Goodson S., Powers S., Cordon-Cardo C., Lowe S.W., Hannon G.J., Hammond S.M. A microRNA polycistron as a potential human oncogene. Nature 2005, 435:828-833.
85. Heldin C.H., Westermark B. Mechanism of action and in vivo role of platelet-derived growth factor. Physiol. Rev. 1999, 79:1283-1316.
86. Heneghan H.M., Miller N., Kerin M.J. Role of microRNAs in obesity and the metabolic syndrome. Obes. Rev. 2010, 11:354-361.
87. Henkemeyer M., Rossi D.J., Holmyard D.P., Puri M.C., Mbamalu G., Harpal K., Shih T.S., Jacks T., Pawson T. Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein. Nature 1995, 377:695-701.
88. Hobson B., Denekamp J. Endothelial proliferation in tumours and normal tissues: continuous labelling studies. Br. J. Cancer 1984, 49:405-413.
89. Hocher B., George I., Rebstock J., Bauch A., Schwarz A., Neumayer H.H., Bauer C. Endothelin system-dependent cardiac remodeling in renovascular hypertension. Hypertension 1999, 33:816-822.
90. Hsiai T.K., Cho S.K., Wong P.K., Ing M., Salazar A., Sevanian A., Navab M., Demer L.L., Ho C.M. Monocyte recruitment to endothelial cells in response to oscillatory shear stress. FASEB J. 2003, 17:1648-1657.
91. Hu S., Huang M., Li Z., Jia F., Ghosh Z., Lijkwan M.A., Fasanaro P., Sun N., Wang X., Martelli F., Robbins R.C., Wu J.C. MicroRNA-210 as a novel therapy for treatment of ischemic heart disease. Circulation 2010, 122:S124-S131.
92. Hussain S.A., Piper M., Fukuhara N., Strochlic L., Cho G., Howitt J.A., Ahmed Y., Powell A.K., Turnbull J.E., Holt C.E., Hohenester E. A molecular mechanism for the heparan sulfate dependence of slit-robo signaling. J. Biol. Chem. 2006, 281:39693-39698.
93. Ikeda S., Kong S.W., Lu J., Bisping E., Zhang H., Allen P.D., Golub T.R., Pieske B., Pu W.T. Altered microRNA expression in human heart disease. Physiol. Genomics 2007, 31:367-373.
94. Inatani M., Irie F., Plump A.S., Tessier-Lavigne M., Yamaguchi Y. Mammalian brain morphogenesis and midline axon guidance require heparan sulfate. Science 2003, 302:1044-1046.
95. Inomata M., Tagawa H., Guo Y.M., Kameoka Y., Takahashi N., Sawada K. MicroRNA-17-92 down-regulates expression of distinct targets in different B-cell lymphoma subtypes. Blood 2009, 113:396-402.
96. Inoue T., Node K. Molecular basis of restenosis and novel issues of drug-eluting stents. Circ. J. 2009, 73:615-621.
97. Iorio M.V., Ferracin M., Liu C.G., Veronese A., Spizzo R., Sabbioni S., Magri E., Pedriali M., Fabbri M., Campiglio M., Menard S., Palazzo J.P., Rosenberg A., Musiani P., Volinia S., Nenci I., Calin G.A., Querzoli P., Negrini M., Croce C.M. MicroRNA gene expression deregulation in human breast cancer. Cancer Res. 2005, 65:7065-7070.
98. Ito H., Hirata Y., Adachi S., Tanaka M., Tsujino M., Koike A., Nogami A., Murumo F., Hiroe M. Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes. J. Clin. Invest. 1993, 92:398-403.
99. Ivan M., Harris A.L., Martelli F., Kulshreshtha R. Hypoxia response and microRNAs: no longer two separate worlds. J. Cell. Mol. Med. 2008, 12:1426-1431.
100. Jazbutyte V., Thum T. MicroRNA-21: from cancer to cardiovascular disease. Curr. Drug Targets 2010, 11:926-935.
101. Jesmin S., Zaedi S., Maeda S., Togashi H., Yamaguchi I., Goto K., Miyauchi T. Endothelin antagonism suppresses plasma and cardiac endothelin-1 levels in SHRSPs at the typical hypertensive stage. Exp. Biol. Med. (Maywood) 2006, 231:919-924.
102. Ji R., Cheng Y., Yue J., Yang J., Liu X., Chen H., Dean D.B., Zhang C. MicroRNA expression signature and antisense-mediated depletion reveal an essential role of MicroRNA in vascular neointimal lesion formation. Circ. Res. 2007, 100:1579-1588.
103. Ji X., Takahashi R., Hiura Y., Hirokawa G., Fukushima Y., Iwai N. Plasma miR-208 as a biomarker of myocardial injury. Clin. Chem. 2009, 55:1944-1949.
104. Jia J., Maccarana M., Zhang X., Bespalov M., Lindahl U., Li J.P. Lack of l-iduronic acid in heparan sulfate affects interaction with growth factors and cell signaling. J. Biol. Chem. 2009, 284:15942-15950.
105. Johnson K.G., Ghose A., Epstein E., Lincecum J., O'Connor M.B., Van Vactor D. Axonal heparan sulfate proteoglycans regulate the distribution and efficiency of the repellent slit during midline axon guidance. Curr. Biol. 2004, 14:499-504.
106. Karp X., Ambros V. Developmental biology. encountering microRNAs in cell fate signaling. Science 2005, 310:1288-1289.
107. Kim V.N. MicroRNA biogenesis: coordinated cropping and dicing. Nat. Rev. Mol. Cell Biol. 2005, 6:376-385.
108. Kim I., Ryu Y.S., Kwak H.J., Ahn S.Y., Oh J.L., Yancopoulos G.D., Gale N.W., Koh G.Y. EphB ligand, ephrinB2, suppresses the VEGF- and angiopoietin 1-induced Ras/mitogen-activated protein kinase pathway in venous endothelial cells. FASEB J. 2002, 16:1126-1128.
109. Kiosses W.B., Daniels R.H., Otey C., Bokoch G.M., Schwartz M.A. A role for p21-activated kinase in endothelial cell migration. J. Cell Biol. 1999, 147:831-844.
110. Kuehbacher A., Urbich C., Zeiher A.M., Dimmeler S. Role of dicer and drosha for endothelial microRNA expression and angiogenesis. Circ. Res. 2007, 101:59-68.
111. Kuhnert F., Mancuso M.R., Hampton J., Stankunas K., Asano T., Chen C.Z., Kuo C.J. Attribution of vascular phenotypes of the murine Egfl7 locus to the microRNA miR-126. Development 2008, 135:3989-3993.
112. Kuijper S., Turner C.J., Adams R.H. Regulation of angiogenesis by eph-ephrin interactions. Trends Cardiovasc. Med. 2007, 17:145-151.
113. Kumar S., Bandyopadhyay U. Free heme toxicity and its detoxification systems in human. Toxicol. Lett. 2005, 157:175-188.
114. Kumarswamy R., Volkmann I., Thum T. Regulation and function of miRNA-21 in health and disease. RNA Biol. 2011, 8(5).
115. Kunsch C., Luchoomun J., Grey J.Y., Olliff L.K., Arrendale R.F., Wasserman M.A., Saxena U., Medford R.M. Selective inhibition of endothelial and monocyte redox-sensitive genes by AGI-1067: a novel antioxidant and anti-inflammatory agent. J. Pharmacol. Exp. Ther. 2004, 3:820-829.
116. Kuwahara K., Barrientos T., Pipes G.C., Li S., Olson E.N. Muscle-specific signaling mechanism that links actin dynamics to serum response factor. Mol. Cell. Biol. 2005, 25:3173-3181.
117. Lagna G., Ku M.M., Nguyen P.H., Neuman N.A., Davis B.N., Hata A. Control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardin-related transcription factors. J. Biol. Chem. 2007, 282:37244-37255.
118. Landgraf P., Rusu M., Sheridan R., Sewer A., Iovino N., Aravin A., Pfeffer S., Rice A., Kamphorst A.O., Landthaler M., Lin C., Socci N.D., Hermida L., Fulci V., Chiaretti S., Foa R., Schliwka J., Fuchs U., Novosel A., Muller R.U., Schermer B., Bissels U., Inman J., Phan Q., Chien M., Weir D.B., Choksi R., De Vita G., Frezzetti D., Trompeter H.I., Hornung V., Teng G., Hartmann G., Palkovits M., Di Lauro R., Wernet P., Macino G., Rogler C.E., Nagle J.W., Ju J., Papavasiliou F.N., Benzing T., Lichter P., Tam W., Brownstein M.J., Bosio A., Borkhardt A., Russo J.J., Sander C., Zavolan M., Tuschl T. A mammalian microRNA expression atlas based on small RNA library sequencing. Cell 2007, 129:1401-1414.
119. Lankat-Buttgereit B., Goke R. The tumour suppressor Pdcd4: recent advances in the elucidation of function and regulation. Biol. Cell. 2009, 101:309-317.
120. le Sage C., Nagel R., Egan D.A., Schrier M., Mesman E., Mangiola A., Anile C., Maira G., Mercatelli N., Ciafre S.A., Farace M.G., Agami R. Regulation of the p27(Kip1) tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferation. EMBO J. 2007, 26:3699-3708.
121. Lee Y., Ahn C., Han J., Choi H., Kim J., Yim J., Lee J., Provost P., Radmark O., Kim S., Kim V.N. The nuclear RNase III drosha initiates microRNA processing. Nature 2003, 425:415-419.
122. Lee E.J., Gusev Y., Jiang J., Nuovo G.J., Lerner M.R., Frankel W.L., Morgan D.L., Postier R.G., Brackett D.J., Schmittgen T.D. Expression profiling identifies microRNA signature in pancreatic cancer. Int. J. Cancer 2007, 120:1046-1054.
123. Leeper N.J., Raiesdana A., Kojima Y., Chun H.J., Azuma J., Maegdefessel L., Kundu R.K., Quertermous T., Tsao P.S., Spin J.M. MicroRNA-26a is a novel regulator of vascular smooth muscle cell function. J. Cell. Physiol. 2011, 226:1035-1043.
124. Legg J.A., Herbert J.M., Clissold P., Bicknell R. Slits and roundabouts in cancer, tumour angiogenesis and endothelial cell migration. Angiogenesis 2008, 11:13-21.
125. Li Y., Song Y.H., Li F., Yang T., Lu Y.W., Geng Y.J. MicroRNA-221 regulates high glucose-induced endothelial dysfunction. Biochem. Biophys. Res. Commun. 2009, 381:81-83.
126. Li D., Yang P., Xiong Q., Song X., Yang X., Liu L., Yuan W., Rui Y.C. MicroRNA-125a/b-5p inhibits endothelin-1 expression in vascular endothelial cells. J. Hypertens. 2010, 28:1646-1654.
127. Lin W.W., Karin M. A cytokine-mediated link between innate immunity, inflammation, and cancer. J. Clin. Invest. 2007, 117:1175-1183.
128. Lin Y., Liu X., Cheng Y., Yang J., Huo Y., Zhang C. Involvement of MicroRNAs in hydrogen peroxide-mediated gene regulation and cellular injury response in vascular smooth muscle cells. J. Biol. Chem. 2009, 284:7903-7913.
129. Linder S., Aepfelbacher M. Podosomes: adhesion hot-spots of invasive cells. Trends Cell Biol. 2003, 13:376-385.
130. Liu N., Olson E.N. MicroRNA regulatory networks in cardiovascular development. Dev. Cell. 2010, 18:510-525.
131. Liu B., Peng X.C., Zheng X.L., Wang J., Qin Y.W. MiR-126 restoration down-regulate VEGF and inhibit the growth of lung cancer cell lines in vitro and in vivo. Lung Cancer 2009, 66:169-175.
132. Liu X., Cheng Y., Zhang S., Lin Y., Yang J., Zhang C. A necessary role of miR-221 and miR-222 in vascular smooth muscle cell proliferation and neointimal hyperplasia. Circ. Res. 2009, 104:476-487.
133. Liu X., Sempere L.F., Galimberti F., Freemantle S.J., Black C., Dragnev K.H., Ma Y., Fiering S., Memoli V., Li H., DiRenzo J., Korc M., Cole C.N., Bak M., Kauppinen S., Dmitrovsky E. Uncovering growth-suppressive MicroRNAs in lung cancer. Clin. Cancer Res. 2009, 15:1177-1183.
134. Loffler D., Brocke-Heidrich K., Pfeifer G., Stocsits C., Hackermuller J., Kretzschmar A.K., Burger R., Gramatzki M., Blumert C., Bauer K., Cvijic H., Ullmann A.K., Stadler P.F., Horn F. Interleukin-6 dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer. Blood 2007, 110:1330-1333.
135. Lorenzen J.M., Haller H., Thum T. MicroRNAs as mediators and therapeutic targets in chronic kidney disease. Nat. Rev. Nephrol. 2011, 7:286-294.
136. Lorenzen J.M., Kielstein J.T., Hafer C., Gupta S.K., Kümpers P., Faulhaber-Walter R., Haller H., Fliser D., Thum T. Circulating miR-210 predicts survival in critically ill patients with acute kidney injury. Clin J Am Soc Nephrol. 2011, 6:1540-1546.
137. Lorenzen J.M., Volkmann I., Fiedler J., Schmidt M., Scheffner I., Haller H., Gwinner W., Thum T. Urinary miR-210 as a mediator of acute T-cell mediated rejection in renal allograft recipients 2011, Am J Transplant.
138. Mann D.L. MicroRNAs and the failing heart. N. Engl. J. Med. 2007, 356:2644-2645.
139. Matharu N.M., Rainger G.E., Vohra R., Nash G.B. Effects of disturbed flow on endothelial cell function: pathogenic implications of modified leukocyte recruitment. Biorheology 2006, 43:31-44.
140. Matkovich S.J., Van Booven D.J., Youker K.A., Torre-Amione G., Diwan A., Eschenbacher W.H., Dorn L.E., Watson M.A., Margulies K.B., Dorn G.W. Reciprocal regulation of myocardial microRNAs and messenger RNA in human cardiomyopathy and reversal of the microRNA signature by biomechanical support. Circulation 2009, 119:1263-1271.
141. Mayo L.D., Kessler K.M., Pincheira R., Warren R.S., Donner D.B. Vascular endothelial cell growth factor activates CRE-binding protein by signaling through the KDR receptor tyrosine kinase. J. Biol. Chem. 2001, 276:25184-25189.
142. Medjkane S., Perez-Sanchez C., Gaggioli C., Sahai E., Treisman R. Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis. Nat. Cell Biol. 2009, 11:257-268.
143. Michael M.Z., O'Connor S.M., van Holst Pellekaan N.G., Young G.P., James R.J. Reduced accumulation of specific microRNAs in colorectal neoplasia. Mol. Cancer. Res. 2003, 1:882-891.
144. Minami Y., Satoh M., Maesawa C., Takahashi Y., Tabuchi T., Itoh T., Nakamura M. Effect of atorvastatin on microRNA 221 / 222 expression in endothelial progenitor cells obtained from patients with coronary artery disease. Eur. J. Clin. Invest. 2009, 39:359-367.
145. Miralles F., Posern G., Zaromytidou A.I., Treisman R. Actin dynamics control SRF activity by regulation of its coactivator MAL. Cell 2003, 113:329-342.
146. Miranda K.C., Huynh T., Tay Y., Ang Y.S., Tam W.L., Thomson A.M., Lim B., Rigoutsos I. A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes. Cell 2006, 126:1203-1217.
147. Miska E.A., Alvarez-Saavedra E., Townsend M., Yoshii A., Sestan N., Rakic P., Constantine-Paton M., Horvitz H.R. Microarray analysis of microRNA expression in the developing mammalian brain. Genome Biol. 2004, 5:R68.
148. Mitchell P.S., Parkin R.K., Kroh E.M., Fritz B.R., Wyman S.K., Pogosova-Agadjanyan E.L., Peterson A., Noteboom J., O'Briant K.C., Allen A., Lin D.W., Urban N., Drescher C.W., Knudsen B.S., Stirewalt D.L., Gentleman R., Vessella R.L., Nelson P.S., Martin D.B., Tewari M. Circulating microRNAs as stable blood-based markers for cancer detection. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:10513-10518.
149. Moller D.E., Kaufman K.D. Metabolic syndrome: a clinical and molecular perspective. Annu. Rev. Med. 2005, 56:45-62.
150. Musiyenko A., Bitko V., Barik S. Ectopic expression of miR-126*, an intronic product of the vascular endothelial EGF-like 7 gene, regulates protein translation and invasiveness of prostate cancer LNCaP cells. J. Mol. Med. 2008, 86:313-322.
151. Nakamura Y., Patrushev N., Inomata H., Mehta D., Urao N., Kim H.W., Razvi M., Kini V., Mahadev K., Goldstein B.J., McKinney R., Fukai T., Ushio-Fukai M. Role of protein tyrosine phosphatase 1B in vascular endothelial growth factor signaling and cell-cell adhesions in endothelial cells. Circ. Res. 2008, 102:1182-1191.
152. Nickenig G., Baudler S., Müller C., Werner C., Werner N., Wetzel H., Strehlow K., Böhm M. Redox-sensitive vascular smooth muscle cell proliferation is mediated by GKLF and Id3 in vitro and in vivo. FASEB J. 2002, 16:1077-1086.
153. Nonami A., Kato R., Taniguchi K., Yoshiga D., Taketomi T., Fukuyama S., Harada M., Sasaki A., Yoshimura A. Spred-1 negatively regulates interleukin-3-mediated ERK/mitogen-activated protein (MAP) kinase activation in hematopoietic cells. J. Biol. Chem. 2004, 279:52543-52551.
154. Nudelman A.S., DiRocco D.P., Lambert T.J., Garelick M.G., Le J., Nathanson N.M., Storm D.R. Neuronal activity rapidly induces transcription of the CREB-regulated microRNA-132, in vivo. Hippocampus 2010, 20:492-498.
155. O'Donnell K.A., Wentzel E.A., Zeller K.I., Dang C.V., Mendell J.T. c-myc-regulated microRNAs modulate E2F1 expression. Nature 2005, 435:839-843.
156. Ota A., Tagawa H., Karnan S., Tsuzuki S., Karpas A., Kira S., Yoshida Y., Seto M. Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma. Cancer Res. 2004, 64:3087-3095.
157. Otterbein L.E., Soares M.P., Yamashita K., Bach F.H. Heme oxygenase-1: unleashing the protective properties of heme. Trends Immunol. 2003, 24:449-455.
158. Owens G.K. Regulation of differentiation of vascular smooth muscle cells. Physiol. Rev. 1995, 75:487-517.
159. Ozsolak F., Poling L.L., Wang Z., Liu H., Liu X.S., Roeder R.G., Zhang X., Song J.S., Fisher D.E. Chromatin structure analyses identify miRNA promoters. Genes Dev. 2008, 22:3172-3183.
160. Palmieri A., Pezzetti F., Brunelli G., Martinelli M., Scapoli L., Arlotti M., Masiero E., Carinci F. Medpor regulates osteoblast's microRNAs. Biomed. Mater. Eng. 2008, 18:91-97.
161. Parker L.H., Schmidt M., Jin S.W., Gray A.M., Beis D., Pham T., Frantz G., Palmieri S., Hillan K., Stainier D.Y., De Sauvage F.J., Ye W. The endothelial-cell-derived secreted factor Egfl7 regulates vascular tube formation. Nature 2004, 428:754-758.
162. Patel S., Leal A.D., Gorski D.H. The homeobox gene gax inhibits angiogenesis through inhibition of nuclear factor-kappaB-dependent endothelial cell gene expression. Cancer Res. 2005, 65:1414-1424.
163. Pickering M.T., Stadler B.M., Kowalik T.F. miR-17 and miR-20a temper an E2F1-induced G1 checkpoint to regulate cell cycle progression. Oncogene 2009, 28:140-145.
164. Poliseno L., Tuccoli A., Mariani L., Evangelista M., Citti L., Woods K., Mercatanti A., Hammond S., Rainaldi G. MicroRNAs modulate the angiogenic properties of HUVECs. Blood 2006, 108:3068-3071.
165. Quintavalle M., Elia L., Condorelli G., Courtneidge S.A. MicroRNA control of podosome formation in vascular smooth muscle cells in vivo and in vitro. J. Cell Biol. 2010, 189:13-22.
166. Rao P.K., Toyama Y., Chiang H.R., Gupta S., Bauer M., Medvid R., Reinhardt F., Liao R., Krieger M., Jaenisch R., Lodish H.F., Blelloch R. Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure. Circ. Res. 2009, 105:585-594.
167. Regalla K., Volkmann I., Thum T. Regulation and function of miR-21 in health and disease. RNA Biol. 2011, 8.
168. Roy S., Khanna S., Hussain S.R., Biswas S., Azad A., Rink C., Gnyawali S., Shilo S., Nuovo G.J., Sen C.K. MicroRNA expression in response to murine myocardial infarction: MiR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue. Cardiovasc. Res. 2009, 82:21-29.
169. Rubanyi G.M., Polokoff M.A. Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology. Pharmacol. Rev. 1994, 46:325-415.
170. Sachdeva M., Zhu S., Wu F., Wu H., Walia V., Kumar S., Elble R., Watabe K., Mo Y.Y. p53 represses c-myc through induction of the tumor suppressor miR-145. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:3207-3212.
171. Saito Y., Friedman J.M., Chihara Y., Egger G., Chuang J.C., Liang G. Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells. Biochem. Biophys. Res. Commun. 2009, 379:726-731.
172. Salmi M., Jalkanen S. Cell-surface enzymes in control of leukocyte trafficking. Nat. Rev. Immunol. 2005, 5:760-771.
173. San Martin A., Lee M.Y., Williams H.C., Mizuno K., Lassegue B., Griendling K.K. Dual regulation of cofilin activity by LIM kinase and slingshot-1L phosphatase controls platelet-derived growth factor-induced migration of human aortic smooth muscle cells. Circ. Res. 2008, 102:432-438.
174. Sandoval K.E., Witt K.A. Blood-brain barrier tight junction permeability and ischemic stroke. Neurobiol. Dis. 2008, 32:200-219.
175. Sarkar J., Gou D., Turaka P., Viktorova E., Ramchandran R., Raj J.U. MicroRNA-21 plays a role in hypoxia-mediated pulmonary artery smooth muscle cell proliferation and migration. Am. J. Physiol. Lung Cell. Mol. Physiol. 2010, 299:L861-L871.
176. Schepeler T., Reinert J.T., Ostenfeld M.S., Christensen L.L., Silahtaroglu A.N., Dyrskjot L., Wiuf C., Sorensen F.J., Kruhoffer M., Laurberg S., Kauppinen S., Orntoft T.F., Andersen C.L. Diagnostic and prognostic microRNAs in stage II colon cancer. Cancer Res. 2008, 68:6416-6424.
177. Semenza G.L. Angiogenesis in ischemic and neoplastic disorders. Annu. Rev. Med. 2003, 54:17-28.
178. Sempere L.F., Christensen M., Silahtaroglu A., Bak M., Heath C.V., Schwartz G., Wells W., Kauppinen S., Cole C.N. Altered MicroRNA expression confined to specific epithelial cell subpopulations in breast cancer. Cancer Res. 2007, 67:11612-11620.
179. Sharifi A.M., He G., Touyz R.M., Schiffrin E.L. Vascular endothelin-1 expression and effect of an endothelin ETA antagonist on structure and function of small arteries from stroke-prone spontaneously hypertensive rats. J. Cardiovasc. Pharmacol. 1998, 31(Suppl. 1):S309-S312.
180. Small E.M., Sutherland L.B., Rajagopalan K.N., Wang S., Olson E.N. MicroRNA-218 regulates vascular patterning by modulation of slit-robo signaling. Circ. Res. 2010, 107:1336-1344.
181. Smith R.C., Branellec D., Gorski D.H., Guo K., Perlman H., Dedieu J.F., Pastore C., Mahfoudi A., Denefle P., Isner J.M., Walsh K. p21CIP1-mediated inhibition of cell proliferation by overexpression of the gax homeodomain gene. Genes Dev. 1997, 11:1674-1689.
182. Soncin F., Mattot V., Lionneton F., Spruyt N., Lepretre F., Begue A., Stehelin D. VE-statin, an endothelial repressor of smooth muscle cell migration. EMBO J. 2003, 22:5700-5711.
183. Stasch J.P., Hirth-Dietrich C., Frobel K., Wegner M. Prolonged endothelin blockade prevents hypertension and cardiac hypertrophy in stroke-prone spontaneously hypertensive rats. Am. J. Hypertens. 1995, 8:1128-1134.
184. Stockton R.A., Schaefer E., Schwartz M.A. P21-activated kinase regulates endothelial permeability through modulation of contractility. J. Biol. Chem. 2004, 279:46621-46630.
185. Suarez Y., Fernandez-Hernando C., Pober J.S., Sessa W.C. Dicer dependent microRNAs regulate gene expression and functions in human endothelial cells. Circ. Res. 2007, 100:1164-1173.
186. Sugishima M., Omata Y., Kakuta Y., Sakamoto H., Noguchi M., Fukuyama K. Crystal structure of rat heme oxygenase-1 in complex with heme. FEBS Lett. 2000, 471:61-66.
187. Sun A., Bagella L., Tutton S., Romano G., Giordano A. From G0 to S phase: a view of the roles played by the retinoblastoma (rb) family members in the rb-E2F pathway. J. Cell. Biochem. 2007, 102:1400-1404.
188. Sun Y., Bai Y., Zhang F., Wang Y., Guo Y., Guo L. miR-126 inhibits non-small cell lung cancer cells proliferation by targeting EGFL7. Biochem. Biophys. Res. Commun. 2010, 391:1483-1489.
189. Sun S.G., Zheng B., Han M., Fang X.M., Li H.X., Miao S.B., Su M., Han Y., Shi H.J., Wen J.K. miR-146a and kruppel-like factor 4 form a feedback loop to participate in vascular smooth muscle cell proliferation. EMBO Rep. 2011, 12:56-62.
190. Takagi T., Iio A., Nakagawa Y., Naoe T., Tanigawa N., Akao Y. Decreased expression of microRNA-143 and -145 in human gastric cancers. Oncology 2009, 77:12-21.
191. Takahashi K., Okita K., Nakagawa M., Yamanaka S. Induction of pluripotent stem cells from fibroblast cultures. Nat. Protoc. 2007, 2:3081-3089.
192. Tan Y., Rouse J., Zhang A., Cariati S., Cohen P., Comb M.J. FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2. EMBO J. 1996, 15:4629-4642.
193. Taniguchi K., Kohno R., Ayada T., Kato R., Ichiyama K., Morisada T., Oike Y., Yonemitsu Y., Maehara Y., Yoshimura A. Spreds are essential for embryonic lymphangiogenesis by regulating vascular endothelial growth factor receptor 3 signaling. Mol. Cell. Biol. 2007, 27:4541-4550.
194. Thompson R.W., Liao S., Curci J.A. Vascular smooth muscle cell apoptosis in abdominal aortic aneurysms. Coron. Artery Dis. 1997, 8:623-631.
195. Thum T., Galuppo P., Wolf C., Fiedler J., Kneitz S., van Laake L.W., Doevendans P.A., Mummery C.L., Borlak J., Haverich A., Gross C., Engelhardt S., Ertl G., Bauersachs J. MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure. Circulation 2007, 116:258-267.
196. Thum T., Gross C., Fiedler J., Fischer T., Kissler S., Bussen M., Galuppo P., Just S., Rottbauer W., Frantz S., Castoldi M., Soutschek J., Koteliansky V., Rosenwald A., Basson M.A., Licht J.D., Pena J.T., Rouhanifard S.H., Muckenthaler M.U., Tuschl T., Martin G.R., Bauersachs J., Engelhardt S. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature 2008, 456:980-984.
197. Tie J., Pan Y., Zhao L., Wu K., Liu J., Sun S., Guo X., Wang B., Gang Y., Zhang Y., Li Q., Qiao T., Zhao Q., Nie Y., Fan D. MiR-218 inhibits invasion and metastasis of gastric cancer by targeting the Robo1 receptor. PLoS Genet. 2010, 6:e1000879.
198. Tijsen A.J., Creemers E.E., Moerland P.D., de Windt L.J., van der Wal A.C., Kok W.E., Pinto Y.M. MiR423-5p as a circulating biomarker for heart failure. Circ. Res. 2010, 106:1035-1039.
199. Ueki K., Fruman D.A., Yballe C.M., Fasshauer M., Klein J., Asano T., Cantley L.C., Kahn C.R. Positive and negative roles of p85 alpha and p85 beta regulatory subunits of phosphoinositide 3-kinase in insulin signaling. J. Biol. Chem. 2003, 278:48453-48466.
200. Urbich C., Kuehbacher A., Dimmeler S. Role of microRNAs in vascular diseases, inflammation, and angiogenesis. Cardiovasc. Res. 2008, 79:581-588.
201. van Rooij E., Sutherland L.B., Liu N., Williams A.H., McAnally J., Gerard R.D., Richardson J.A., Olson E.N. A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:18255-18260.
202. van Rooij E., Sutherland L.B., Qi X., Richardson J.A., Hill J., Olson E.N. Control of stress-dependent cardiac growth and gene expression by a microRNA. Science 2007, 316:575-579.
203. van Rooij E., Sutherland L.B., Thatcher J.E., DiMaio J.M., Naseem R.H., Marshall W.S., Hill J.A., Olson E.N. Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:13027-13032.
204. van Solingen C., Seghers L., Bijkerk R., Duijs J.M., Roeten M.K., van Oeveren-Rietdijk A.M., Baelde H.J., Monge M., Vos J.B., de Boer H.C., Quax P.H., Rabelink T.J., van Zonneveld A.J. Antagomir-mediated silencing of endothelial cell specific microRNA-126 impairs ischemia-induced angiogenesis. J. Cell. Mol. Med. 2009, 13:1577-1585.
205. Vandewalle C., Comijn J., De Craene B., Vermassen P., Bruyneel E., Andersen H., Tulchinsky E., Van Roy F., Berx G. SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell-cell junctions. Nucleic Acids Res. 2005, 33:6566-6578.
206. Vo N., Klein M.E., Varlamova O., Keller D.M., Yamamoto T., Goodman R.H., Impey S. A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:16426-16431.
207. Wagener F.A., Volk H.D., Willis D., Abraham N.G., Soares M.P., Adema G.J., Figdor C.G. Different faces of the heme-heme oxygenase system in inflammation. Pharmacol. Rev. 2003, 55:551-571.
208. Wakioka T., Sasaki A., Kato R., Shouda T., Matsumoto A., Miyoshi K., Tsuneoka M., Komiya S., Baron R., Yoshimura A. Spred is a sprouty-related suppressor of ras signalling. Nature 2001, 412:647-651.
209. Wang B., Xiao Y., Ding B.B., Zhang N., Yuan X., Gui L., Qian K.X., Duan S., Chen Z., Rao Y., Geng J.G. Induction of tumor angiogenesis by slit-robo signaling and inhibition of cancer growth by blocking robo activity. Cancer. Cell. 2003, 4:19-29.
210. Wang N., Miao H., Li Y.S., Zhang P., Haga J.H., Hu Y., Young A., Yuan S., Nguyen P., Wu C.C., Chien S. Shear stress regulation of kruppel-like factor 2 expression is flow pattern-specific. Biochem. Biophys. Res. Commun. 2006, 341:1244-1251.
211. Wang T., Zhang X., Obijuru L., Laser J., Aris V., Lee P., Mittal K., Soteropoulos P., Wei J.J. A micro-RNA signature associated with race, tumor size, and target gene activity in human uterine leiomyomas. Genes Chromosomes Cancer 2007, 46:336-347.
212. Wang Y., Medvid R., Melton C., Jaenisch R., Blelloch R. DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nat. Genet. 2007, 39:380-385.
213. Wang C., Han M., Zhao X.M., Wen J.K. Kruppel-like factor 4 is required for the expression of vascular smooth muscle cell differentiation marker genes induced by all-trans retinoic acid. J. Biochem. 2008, 144:313-321.
214. Wang Q., Huang Z., Xue H., Jin C., Ju X.L., Han J.D., Chen Y.G. MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4. Blood 2008, 111:588-595.
215. Wang Q., Wang Y., Minto A.W., Wang J., Shi Q., Li X., Quigg R.J. MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy. FASEB J. 2008, 22:4126-4135.
216. Wang S., Aurora A.B., Johnson B.A., Qi X., McAnally J., Hill J.A., Richardson J.A., Bassel-Duby R., Olson E.N. The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev. Cell. 2008, 15:261-271.
217. Wang S., Bian C., Yang Z., Bo Y., Li J., Zeng L., Zhou H., Zhao R.C. miR-145 inhibits breast cancer cell growth through RTKN. Int. J. Oncol. 2009, 34:1461-1466.
218. Wang X.H., Qian R.Z., Zhang W., Chen S.F., Jin H.M., Hu R.M. MicroRNA-320 expression in myocardial microvascular endothelial cells and its relationship with insulin-like growth factor-1 in type 2 diabetic rats. Clin. Exp. Pharmacol. Physiol. 2009, 36:181-188.
219. Wang K.C., Garmire L.X., Young A., Nguyen P., Trinh A., Subramaniam S., Wang N., Shyy J.Y., Li Y.S., Chien S. Role of microRNA-23b in flow-regulation of rb phosphorylation and endothelial cell growth. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:3234-3239.
220. Warner B.J., Blain S.W., Seoane J., Massague J. Myc downregulation by transforming growth factor beta required for activation of the p15(Ink4b) G(1) arrest pathway. Mol. Cell. Biol. 1999, 19:5913-5922.
221. Wassmann S., Wassmann K., Jung A., Velten M., Knuefermann P., Petoumenos V., Becher U., Werner C., Mueller C., Nickenig G. Induction of p53 by GKLF is essential for inhibition of proliferation of vascular smooth muscle cells. J. Mol. Cell. Cardiol. 2007, 43:301-307.
222. Weber C. Novel mechanistic concepts for the control of leukocyte transmigration: specialization of integrins, chemokines, and junctional molecules. J. Mol. Med. 2003, 81:4-19.
223. Weber M., Baker M.B., Moore J.P., Searles C.D. MiR-21 is induced in endothelial cells by shear stress and modulates apoptosis and eNOS activity. Biochem. Biophys. Res. Commun. 2010, 393:643-648.
224. Wiemer E.A. The role of microRNAs in cancer: no small matter. Eur. J. Cancer 2007, 43:1529-1544.
225. Williams A.E., Perry M.M., Moschos S.A., Larner-Svensson H.M., Lindsay M.A. Role of miRNA-146a in the regulation of the innate immune response and cancer. Biochem. Soc. Trans. 2008, 36:1211-1215.
226. Wu L., Belasco J.G. Examining the influence of microRNAs on translation efficiency and on mRNA deadenylation and decay. Methods Enzymol. 2008, 449:373-393.
227. Xu P., Guo M., Hay B.A. MicroRNAs and the regulation of cell death. Trends Genet. 2004, 20:617-624.
228. Xu H., Duan J., Wang W., Dai S., Wu Y., Sun R., Ren J. Reactive oxygen species mediate oxidized low-density lipoprotein-induced endothelin-1 gene expression via extracellular signal-regulated kinase in vascular endothelial cells. J. Hypertens. 2008, 26:956-963.
229. Xu N., Papagiannakopoulos T., Pan G., Thomson J.A., Kosik K.S. MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell 2009, 137:647-658.
230. Yanagisawa M., Kurihara H., Kimura S., Tomobe Y., Kobayashi M., Mitsui Y., Yazaki Y., Goto K., Masaki T. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 1988, 332:411-415.
231. Yang Z., Wu J. MicroRNAs and regenerative medicine. DNA Cell Biol. 2007, 26:257-264.
232. Yang W.J., Yang D.D., Na S., Sandusky G.E., Zhang Q., Zhao G. Dicer is required for embryonic angiogenesis during mouse development. J. Biol. Chem. 2005, 280:9330-9335.
233. Yayon A., Klagsbrun M., Esko J.D., Leder P., Ornitz D.M. Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell 1991, 64:841-848.
234. Yi R., Qin Y., Macara I.G., Cullen B.R. Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev. 2003, 17:3011-3016.
235. Yin K.J., Deng Z., Hamblin M., Xiang Y., Huang H., Zhang J., Jiang X., Wang Y., Chen Y.E. Peroxisome proliferator-activated receptor delta regulation of miR-15a in ischemia-induced cerebral vascular endothelial injury. J. Neurosci. 2010, 30:6398-6408.
236. Zahradka P., Wright B., Fuerst M., Yurkova N., Molnar K., Taylor C.G. Peroxisome proliferator-activated receptor alpha and gamma ligands differentially affect smooth muscle cell proliferation and migration. J. Pharmacol. Exp. Ther. 2006, 317:651-659.
237. Zampetaki A., Kiechl S., Drozdov I., Willeit P., Mayr U., Prokopi M., Mayr A., Weger S., Oberhollenzer F., Bonora E., Shah A., Willeit J., Mayr M. Plasma microRNA profiling reveals loss of endothelial miR-126 and other microRNAs in type 2 diabetes. Circ. Res. 2010, 107:810-817.
238. Zhang C. MicroRNA-145 in vascular smooth muscle cell biology: a new therapeutic target for vascular disease. Cell. Cycle 2009, 8:3469-3473.
239. Zhao Y., Srivastava D. A developmental view of microRNA function. Trends Biochem. Sci. 2007, 32:189-197.
240. Zhou Q., Gallagher R., Ufret-Vincenty R., Li X., Olson E.N., Wang S. Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23~27~24 clusters. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:8287-8292.