MiR-146a and Krüppel-like factor 4 form a feedback loop to participate in vascular smooth muscle cell proliferation

EMBO Reports

Volumn 12, Issue 1, 2011, Pages 56-62

  Sun, Shao Guang ^a   Zheng, Bin ^a   Han, Mei ^a   Fang, Xin Mei ^a   Li, Hui Xuan ^a   Miao, Sui Bing ^a   Su, Ming ^a   Han, Yi ^a   Shi, Hui Jing ^a   Wen, Jin Kun ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

Kr ppel like factor 4; microRNA; miR 146a; proliferation; vascular smooth muscle cells

Indexed keywords

COMPLEMENTARY RNA; KRUPPEL LIKE FACTOR 4; KRUPPEL LIKE FACTOR 5; MICRORNA; OLIGONUCLEOTIDE;

3' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY INTIMA PROLIFERATION; ARTICLE; CAROTID ARTERY INJURY; CELL PROLIFERATION; CONTROLLED STUDY; FEEDBACK SYSTEM; GENE OVEREXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; RAT; SMOOTH MUSCLE FIBER; TRANSCRIPTION REGULATION; VASCULAR SMOOTH MUSCLE;

ANIMALS; BASE SEQUENCE; CELL PROLIFERATION; FEEDBACK, PHYSIOLOGICAL; HUMANS; HYPERPLASIA; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MALE; MICRORNAS; MOLECULAR SEQUENCE DATA; MYOCYTES, SMOOTH MUSCLE; NEOINTIMA; RATS; RATS, SPRAGUE-DAWLEY; RNA INTERFERENCE; SEQUENCE ALIGNMENT; TRANSCRIPTION, GENETIC;

RATTUS;

EID: 78650897480     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2010.172     Document Type: Article

References (13)

1. Chan JA, Krichevsky AM, Kosik KS (2005) MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res 65: 6029-6033
2. Chen T, Huang ZQ, Wang LS, Wang Y, Wu FZ, Meng S, Wang CQ (2009) MicroRNA-125a-5p partly regulates the inflammatory response, lipid uptake, and ORP9 expression in oxLDL-stimulated monocyte/macrophages. Cardiovasc Res 83: 131-139
3. Cheng AM, Byrom MW, Shelton J, Ford LP (2005) Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis. Nucleic Acids Res 33: 1290-1297
4. Cordes KR, Sheehy NT, White MP, Berry EC, Morton SU, Muth AN, Lee TH, Miano JM, Ivey KN, Srivastava D (2009) miR-145 and miR-143 regulate smooth muscle cell fate and plasticity. Nature 460: 705-710
5. Davis BN, Hilyard AC, Nguyen PH, Lagna G, Hata A (2009) Induction of microRNA-221 by platelet-derived growth factor signaling is critical for modulation of vascular smooth muscle phenotype. J Biol Chem 284: 3728-3738
6. Dang DT, Zhao W, Mahatan CS, Geiman DE, Yang VW (2002) Opposing effects of Krü ppel-like factor 4 (gut-enriched Krü ppel-like factor) and Krüppel-like factor 5 (intestinal-enriched Krü ppel-like factor) on the promoter of the Krüppel-like factor 4 gene. Nucleic Acids Res 30: 2736-2741
7. Ji R, Cheng Y, Yue J, Yang J, Liu X, Chen H, Dean DB, Zhang C (2007) MicroRNA expression signature and antisense-mediated depletion reveal an essential role of MicroRNA in vascular neointimal lesion formation. Circ Res 100: 1579-1588
8. Kawai-Kowase K, Owens GK (2007) Multiple repressor pathways contribute to phenotypic switching of vascular smooth muscle cells. Am J Physiol Cell Physiol 292: C59-C69
9. Kumar MS, Owens GK (2003) Combinatorial control of smooth muscle-specific gene expression. Arterioscler Thromb Vasc Biol 23: 737-747
10. Wang C, Han M, Zhao XM, Wen JK (2008) Krüppel-like factor 4 is required for the expression of vascular smooth muscle cell differentiation marker genes induced by all-trans retinoic acid. J Biochem 144: 313-321
11. Wassmann S, Wassmann K, Jung A, Velten M, Knuefermann P, Petoumenos V, Becher U, Werner C, Mueller C, Nickenig G (2007) Induction of p53 by GKLF is essential for inhibition of proliferation of vascular smooth muscle cells. J Mol Cell Cardiol 43: 301-307
12. Williams AE, Perry MM, Moschos SA, Larner-Svensson HM, Lindsay MA (2008) Role of miRNA-146a in the regulation of the innate immune response and cancer. Biochem Soc Trans 36: 1211-1215
13. Zheng B, Bernier M, Zhang XH, Meng F, Miao SB, He M, Zhao XM, Wen JK (2009) Krüppel-like factor 4 inhibits proliferation by platelet-derived growth factor receptor beta-mediated, not by retinoic acid receptor alpha-mediated, phosphatidylinositol 3-kinase and ERK signaling in vascular smooth muscle cells. J Biol Chem 284: 22773-22785