메뉴 건너뛰기




Volumn 68, Issue 22, 2011, Pages 3661-3673

Expression and functional importance of innate immune receptors by intestinal epithelial cells

Author keywords

Commensal bacteria; Epithelial cells; Innate immune response; Nucleotide oligomerization domain like receptors; Pattern recognition receptors; Toll like receptors

Indexed keywords

BETA DEFENSIN; CASPASE RECRUITMENT DOMAIN PROTEIN 15; CASPASE RECRUITMENT DOMAIN PROTEIN 4; CRYOPYRIN; DEFENSIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN M; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; MYELOID DIFFERENTIATION FACTOR 88; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; PEPTIDOGLYCAN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 9; VIRUS RNA;

EID: 82155162450     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-011-0829-9     Document Type: Review
Times cited : (46)

References (126)
  • 2
    • 0032406286 scopus 로고    scopus 로고
    • Molecular mechanisms of enteroendocrine differentiation
    • Hocker M, Wiedenmann B (1998) Molecular mechanisms of enteroendocrine differentiation. Ann N Y Acad Sci 859:160-174
    • (1998) Ann N Y Acad Sci , vol.859 , pp. 160-174
    • Hocker, M.1    Wiedenmann, B.2
  • 3
    • 79954915318 scopus 로고    scopus 로고
    • Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis
    • Bevins CL, Salzman NH (2011) Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis. Nat Rev Microbiol 9:356-368
    • (2011) Nat Rev Microbiol , vol.9 , pp. 356-368
    • Bevins, C.L.1    Salzman, N.H.2
  • 4
    • 1342303482 scopus 로고    scopus 로고
    • Of Mice and Not Men: Differences between Mouse and Human Immunology
    • Mestas J, Hughes CC (2004) Of mice and not men: differences between mouse and human immunology. J Immunol 172:2731-2738 (Pubitemid 38263654)
    • (2004) Journal of Immunology , vol.172 , Issue.5 , pp. 2731-2738
    • Mestas, J.1    Hughes, C.C.W.2
  • 5
    • 34249313567 scopus 로고    scopus 로고
    • Paneth cells, defensins, and the commensal microbiota: A hypothesis on intimate interplay at the intestinal mucosa
    • DOI 10.1016/j.smim.2007.04.002, PII S1044532307000322, The armed truce between the intestinal microflora and host mucosal immunity
    • Salzman NH et al (2007) Paneth cells, defensins, and the commensal microbiota: a hypothesis on intimate interplay at the intestinal mucosa. Semin Immunol 19:70-83 (Pubitemid 46824070)
    • (2007) Seminars in Immunology , vol.19 , Issue.2 , pp. 70-83
    • Salzman, N.H.1    Underwood, M.A.2    Bevins, C.L.3
  • 6
    • 56749146467 scopus 로고    scopus 로고
    • Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis
    • DOI 10.1038/nature07450, PII NATURE07450
    • Bouskra D et al (2008) Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis. Nature 456:507-510 (Pubitemid 352759006)
    • (2008) Nature , vol.456 , Issue.7221 , pp. 507-510
    • Bouskra, D.1    Brezillon, C.2    Berard, M.3    Werts, C.4    Varona, R.5    Boneca, I.G.6    Eberl, G.7
  • 7
    • 77955665774 scopus 로고    scopus 로고
    • Bacteria and MAMP-induced morphogenesis of the immune system
    • Eberl G, Boneca IG (2010) Bacteria and MAMP-induced morphogenesis of the immune system. Curr Opin Immunol 22:448-454
    • (2010) Curr Opin Immunol , vol.22 , pp. 448-454
    • Eberl, G.1    Boneca, I.G.2
  • 11
    • 77958497213 scopus 로고    scopus 로고
    • Heads up! How the intestinal epithelium safeguards mucosal barrier immunity through the inflammasome and beyond
    • Cario E (2010) Heads up! How the intestinal epithelium safeguards mucosal barrier immunity through the inflammasome and beyond. Curr Opin Gastroenterol 26:583-590
    • (2010) Curr Opin Gastroenterol , vol.26 , pp. 583-590
    • Cario, E.1
  • 13
    • 77249118801 scopus 로고    scopus 로고
    • The inflammasomes: Mechanisms of activation and function
    • Latz E (2010) The inflammasomes: mechanisms of activation and function. Curr Opin Immunol 22:28-33
    • (2010) Curr Opin Immunol , vol.22 , pp. 28-33
    • Latz, E.1
  • 14
    • 74549175680 scopus 로고    scopus 로고
    • RIGorous detection: Exposing virus through RNA sensing
    • Rehwinkel J, Reis e Sousa C (2010) RIGorous detection: exposing virus through RNA sensing. Science 327:284-286
    • (2010) Science , vol.327 , pp. 284-286
    • Rehwinkel, J.1    Reis E Sousa, C.2
  • 15
    • 75649093343 scopus 로고    scopus 로고
    • Toll-like receptor signalling in the intestinal epithelium: How bacterial recognition shapes intestinal function
    • Abreu MT (2010) Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function. Nat Rev Immunol 10:131-144
    • (2010) Nat Rev Immunol , vol.10 , pp. 131-144
    • Abreu, M.T.1
  • 16
    • 0035424901 scopus 로고    scopus 로고
    • Decreased expression of Toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide
    • Abreu MT et al (2001) Decreased expression of Toll-like receptor-4 and MD-2 correlates with intestinal epithelial cell protection against dysregulated proinflammatory gene expression in response to bacterial lipopolysaccharide. J Immunol 167:1609-1616 (Pubitemid 32703162)
    • (2001) Journal of Immunology , vol.167 , Issue.3 , pp. 1609-1616
    • Abreu, M.T.1    Vora, P.2    Faure, E.3    Thomas, L.S.4    Arnold, E.T.5    Arditi, M.6
  • 18
    • 0037018107 scopus 로고    scopus 로고
    • Toll-like receptor 4 resides in the Golgi apparatus and colocalizes with internalized lipopolysaccharide in intestinal epithelial cells
    • DOI 10.1084/jem.20011788
    • Hornef MW et al (2002) Toll-like receptor 4 resides in the Golgi apparatus and colocalizes with internalized lipopolysaccharide in intestinal epithelial cells. J Exp Med 195:559-570 (Pubitemid 34461501)
    • (2002) Journal of Experimental Medicine , vol.195 , Issue.5 , pp. 559-570
    • Hornef, M.W.1    Frisan, T.2    Vandewalle, A.3    Normark, S.4    Richter-Dahlfors, A.5
  • 19
    • 0142157000 scopus 로고    scopus 로고
    • Intracellular Recognition of Lipopolysaccharide by Toll-like Receptor 4 in Intestinal Epithelial Cells
    • DOI 10.1084/jem.20022194
    • Hornef MW et al (2003) Intracellular recognition of lipopolysaccharide by toll-like receptor 4 in intestinal epithelial cells. J Exp Med 198:1225-1235 (Pubitemid 37323387)
    • (2003) Journal of Experimental Medicine , vol.198 , Issue.8 , pp. 1225-1235
    • Hornef, M.W.1    Normark, B.H.2    Vandewalle, A.3    Normark, S.4
  • 21
    • 0033591330 scopus 로고    scopus 로고
    • Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB
    • Inohara N et al (1999) Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB. J Biol Chem 274:14560-14567
    • (1999) J Biol Chem , vol.274 , pp. 14560-14567
    • Inohara, N.1
  • 22
    • 0035895992 scopus 로고    scopus 로고
    • Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB
    • Ogura Y et al (2001) Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB. J Biol Chem 276:4812-4818
    • (2001) J Biol Chem , vol.276 , pp. 4812-4818
    • Ogura, Y.1
  • 23
    • 1342344961 scopus 로고    scopus 로고
    • Nod1 Is An Essential Signal Transducer in Intestinal Epithelial Cells Infected with Bacteria That Avoid Recognition by Toll-Like Receptors
    • DOI 10.1128/IAI.72.3.1487-1495.2004
    • Kim JG et al (2004) Nod1 is an essential signal transducer in intestinal epithelial cells infected with bacteria that avoid recognition by Toll-like receptors. Infect Immun 72:1487-1495 (Pubitemid 38263771)
    • (2004) Infection and Immunity , vol.72 , Issue.3 , pp. 1487-1495
    • Kim, J.G.1    Lee, S.J.2    Kagnoff, M.F.3
  • 29
    • 40949134086 scopus 로고    scopus 로고
    • TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β
    • DOI 10.1038/ni1569, PII NI1569
    • Kagan JC et al (2008) TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol 9:361-368 (Pubitemid 351405105)
    • (2008) Nature Immunology , vol.9 , Issue.4 , pp. 361-368
    • Kagan, J.C.1    Su, T.2    Horng, T.3    Chow, A.4    Akira, S.5    Medzhitov, R.6
  • 30
    • 22244465576 scopus 로고    scopus 로고
    • Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-κB activation in muramyl dipeptide recognition
    • DOI 10.1083/jcb.200502153
    • Barnich N et al (2005) Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition. J Cell Biol 170:21-26 (Pubitemid 40994092)
    • (2005) Journal of Cell Biology , vol.170 , Issue.1 , pp. 21-26
    • Barnich, N.1    Aguirre, J.E.2    Reinecker, H.-C.3    Xavier, R.4    Podolsky, D.K.5
  • 31
    • 38049177193 scopus 로고    scopus 로고
    • The pattern-recognition molecule Nod1 is localized at the plasma membrane at sites of bacterial interaction
    • Kufer TA et al (2008) The pattern-recognition molecule Nod1 is localized at the plasma membrane at sites of bacterial interaction. Cell Microbiol 10:477-486
    • (2008) Cell Microbiol , vol.10 , pp. 477-486
    • Kufer, T.A.1
  • 33
    • 33846936219 scopus 로고    scopus 로고
    • RICK/RIP2 mediates innate immune responses induced through Nod1 and Nod2 but not TLRs
    • Park JH et al (2007) RICK/RIP2 mediates innate immune responses induced through Nod1 and Nod2 but not TLRs. J Immunol 178:2380-2386
    • (2007) J Immunol , vol.178 , pp. 2380-2386
    • Park, J.H.1
  • 34
    • 33846469538 scopus 로고    scopus 로고
    • The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens
    • Hsu YM et al (2007) The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nat Immunol 8:198-205
    • (2007) Nat Immunol , vol.8 , pp. 198-205
    • Hsu, Y.M.1
  • 35
    • 73849121209 scopus 로고    scopus 로고
    • Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry
    • Travassos LH et al (2010) Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol 11:55-62
    • (2010) Nat Immunol , vol.11 , pp. 55-62
    • Travassos, L.H.1
  • 36
    • 77951911814 scopus 로고    scopus 로고
    • Control of infection by pyroptosis and autophagy: Role of TLR and NLR
    • Bortoluci KR, Medzhitov R (2010) Control of infection by pyroptosis and autophagy: role of TLR and NLR. Cell Mol Life Sci 67:1643-1651
    • (2010) Cell Mol Life Sci , vol.67 , pp. 1643-1651
    • Bortoluci, K.R.1    Medzhitov, R.2
  • 37
    • 46749136412 scopus 로고    scopus 로고
    • When Signaling Pathways Collide: Positive and Negative Regulation of Toll-like Receptor Signal Transduction
    • DOI 10.1016/j.immuni.2008.06.004, PII S1074761308002793
    • O'Neill LA (2008) When signaling pathways collide: positive and negative regulation of Toll-like receptor signal transduction. Immunity 29:12-20 (Pubitemid 351952460)
    • (2008) Immunity , vol.29 , Issue.1 , pp. 12-20
    • O'Neill, L.A.J.1
  • 38
    • 77149169405 scopus 로고    scopus 로고
    • Nod2 regulates the host response towards microflora by modulating T cell function and epithelial permeability in mouse Peyer's patches
    • Barreau F et al (2010) Nod2 regulates the host response towards microflora by modulating T cell function and epithelial permeability in mouse Peyer's patches. Gut 59:207-217
    • (2010) Gut , vol.59 , pp. 207-217
    • Barreau, F.1
  • 39
    • 34447532521 scopus 로고    scopus 로고
    • TLRs in the Gut. IV. Negative regulation of Toll-like receptors and intestinal homeostasis: Addition by subtraction
    • DOI 10.1152/ajpgi.00531.2006
    • Shibolet O, Podolsky DK (2007) TLRs in the gut. IV. Negative regulation of Toll-like receptors and intestinal homeostasis: addition by subtraction. Am J Physiol Gastrointest Liver Physiol 292:G1469-G1473 (Pubitemid 47080581)
    • (2007) American Journal of Physiology - Gastrointestinal and Liver Physiology , vol.292 , Issue.6
    • Shibolet, O.1    Podolsky, D.K.2
  • 41
    • 77958105934 scopus 로고    scopus 로고
    • MiR-146a mediates protective innate immune tolerance in the neonate intestine
    • Chassin C et al (2010) miR-146a mediates protective innate immune tolerance in the neonate intestine. Cell Host Microbe 8:358-368
    • (2010) Cell Host Microbe , vol.8 , pp. 358-368
    • Chassin, C.1
  • 42
    • 77956025260 scopus 로고    scopus 로고
    • New insights into the regulation of signalling by Toll-like receptors and nod-like receptors
    • Coll RC, O'Neill LA (2010) New insights into the regulation of signalling by Toll-like receptors and nod-like receptors. J Innate Immun 2:406-421
    • (2010) J Innate Immun , vol.2 , pp. 406-421
    • Coll, R.C.1    O'Neill, L.A.2
  • 43
    • 70349436102 scopus 로고    scopus 로고
    • Induction of microRNA-155 during Helicobacter pylori infection and its negative regulatory role in the inflammatory response
    • Xiao B et al (2009) Induction of microRNA-155 during Helicobacter pylori infection and its negative regulatory role in the inflammatory response. J Infect Dis 200:916-925
    • (2009) J Infect Dis , vol.200 , pp. 916-925
    • Xiao, B.1
  • 44
    • 58549111588 scopus 로고    scopus 로고
    • Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface
    • Vaishnava S et al (2008) Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface. Proc Natl Acad Sci USA 105:20858-20863
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 20858-20863
    • Vaishnava, S.1
  • 46
    • 54449083567 scopus 로고    scopus 로고
    • The inner of the two Muc2 mucindependent mucus layers in colon is devoid of bacteria
    • Johansson ME et al (2008) The inner of the two Muc2 mucindependent mucus layers in colon is devoid of bacteria. Proc Natl Acad Sci USA 105:15064-15069
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 15064-15069
    • Johansson, M.E.1
  • 47
    • 67649231565 scopus 로고    scopus 로고
    • Colitis-associated variant of TLR2 causes impaired mucosal repair because of TFF3 deficiency
    • Podolsky DK et al (2009) Colitis-associated variant of TLR2 causes impaired mucosal repair because of TFF3 deficiency. Gastroenterology 137:209-220
    • (2009) Gastroenterology , vol.137 , pp. 209-220
    • Podolsky, D.K.1
  • 48
    • 78650866071 scopus 로고    scopus 로고
    • NF-kappaB in the regulation of epithelial homeostasis and inflammation
    • Wullaert A et al (2011) NF-kappaB in the regulation of epithelial homeostasis and inflammation. Cell Res 21:146-158
    • (2011) Cell Res , vol.21 , pp. 146-158
    • Wullaert, A.1
  • 50
    • 57149141634 scopus 로고    scopus 로고
    • Hypomorphic nuclear factor-kappaB essential modulator mutation database and reconstitution system identifies phenotypic and immunologic diversity
    • e16
    • Hanson EP et al (2008) Hypomorphic nuclear factor-kappaB essential modulator mutation database and reconstitution system identifies phenotypic and immunologic diversity. J Allergy Clin Immunol 122:1169-1177 e16
    • (2008) J Allergy Clin Immunol , vol.122 , pp. 1169-1177
    • Hanson, E.P.1
  • 51
    • 44349195660 scopus 로고    scopus 로고
    • The regulation of IgA class switching
    • DOI 10.1038/nri2322, PII NRI2322
    • Cerutti A (2008) The regulation of IgA class switching. Nat Rev Immunol 8:421-434 (Pubitemid 351733417)
    • (2008) Nature Reviews Immunology , vol.8 , Issue.6 , pp. 421-434
    • Cerutti, A.1
  • 53
    • 48549103766 scopus 로고    scopus 로고
    • Toll-like receptor signaling in small intestinal epithelium promotes B-cell recruitment and IgA production in lamina propria
    • Shang L et al (2008) Toll-like receptor signaling in small intestinal epithelium promotes B-cell recruitment and IgA production in lamina propria. Gastroenterology 135:529-538
    • (2008) Gastroenterology , vol.135 , pp. 529-538
    • Shang, L.1
  • 54
    • 0034445697 scopus 로고    scopus 로고
    • Differential alteration in intestinal epithelial cell expression of Toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease
    • DOI 10.1128/IAI.68.12.7010-7017.2000
    • Cario E, Podolsky DK (2000) Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease. Infect Immun 68:7010-7017 (Pubitemid 32463415)
    • (2000) Infection and Immunity , vol.68 , Issue.12 , pp. 7010-7017
    • Cario, E.1    Podolsky, D.K.2
  • 55
    • 69949105213 scopus 로고    scopus 로고
    • Toll-like receptors (TLRs) and Nod-like receptors (NLRs) in inflammatory disorders
    • Fukata M et al (2009) Toll-like receptors (TLRs) and Nod-like receptors (NLRs) in inflammatory disorders. Semin Immunol 21:242-253
    • (2009) Semin Immunol , vol.21 , pp. 242-253
    • Fukata, M.1
  • 57
    • 3242664636 scopus 로고    scopus 로고
    • Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis
    • DOI 10.1016/j.cell.2004.07.002, PII S0092867404006610
    • Rakoff-Nahoum S et al (2004) Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis. Cell 118:229-241 (Pubitemid 38962578)
    • (2004) Cell , vol.118 , Issue.2 , pp. 229-241
    • Rakoff-Nahoum, S.1    Paglino, J.2    Eslami-Varzaneh, F.3    Edberg, S.4    Medzhitov, R.5
  • 58
    • 69249109191 scopus 로고    scopus 로고
    • TLR2 mediates gap junctional intercellular communication through connexin-43 in intestinal epithelial barrier injury
    • Ey B et al (2009) TLR2 mediates gap junctional intercellular communication through connexin-43 in intestinal epithelial barrier injury. J Biol Chem 284:22332-22343
    • (2009) J Biol Chem , vol.284 , pp. 22332-22343
    • Ey, B.1
  • 59
    • 38849189905 scopus 로고    scopus 로고
    • MyD88 signalling plays a critical role in host defence by controlling pathogen burden and promoting epithelial cell homeostasis during Citrobacterrodentium-induced colitis
    • DOI 10.1111/j.1462-5822.2007.01071.x
    • Gibson DL et al (2008) MyD88 signalling plays a critical role in host defence by controlling pathogen burden and promoting epithelial cell homeostasis during Citrobacter rodentiuminduced colitis. Cell Microbiol 10:618-631 (Pubitemid 351194091)
    • (2008) Cellular Microbiology , vol.10 , Issue.3 , pp. 618-631
    • Gibson, D.L.1    Ma, C.2    Bergstrom, K.S.B.3    Huang, J.T.4    Man, C.5    Vallance, B.A.6
  • 60
    • 77955346494 scopus 로고    scopus 로고
    • Pathogenic and protective roles of MyD88 in leukocytes and epithelial cells in mouse models of inflammatory bowel disease
    • Asquith MJ et al (2010) Pathogenic and protective roles of MyD88 in leukocytes and epithelial cells in mouse models of inflammatory bowel disease. Gastroenterology 139:519-529
    • (2010) Gastroenterology , vol.139 , pp. 519-529
    • Asquith, M.J.1
  • 61
    • 33747114270 scopus 로고    scopus 로고
    • Role of Toll-like Receptors in Spontaneous Commensal-Dependent Colitis
    • DOI 10.1016/j.immuni.2006.06.010, PII S107476130600344X
    • Rakoff-Nahoum S et al (2006) Role of Toll-like receptors in spontaneous commensal-dependent colitis. Immunity 25:319-329 (Pubitemid 44224143)
    • (2006) Immunity , vol.25 , Issue.2 , pp. 319-329
    • Rakoff-Nahoum, S.1    Hao, L.2    Medzhitov, R.3
  • 62
    • 78650548872 scopus 로고    scopus 로고
    • MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands
    • Brandl K et al (2010) MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands. Proc Natl Acad Sci USA 107:19967-19972
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 19967-19972
    • Brandl, K.1
  • 64
    • 0035978651 scopus 로고    scopus 로고
    • Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
    • Hugot JP et al (2001) Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411:599-603
    • (2001) Nature , vol.411 , pp. 599-603
    • Hugot, J.P.1
  • 68
    • 79960302320 scopus 로고    scopus 로고
    • Anti-inflammatory capacity of selected lactobacilli in experimental colitis is driven by NOD2-mediated recognition of a specific peptidoglycan-derived muropeptide
    • Fernandez EM et al (2011) Anti-inflammatory capacity of selected lactobacilli in experimental colitis is driven by NOD2-mediated recognition of a specific peptidoglycan-derived muropeptide. Gut 60:1050-1059
    • (2011) Gut , vol.60 , pp. 1050-1059
    • Fernandez, E.M.1
  • 70
    • 4444253690 scopus 로고    scopus 로고
    • NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses
    • DOI 10.1038/ni1092
    • Watanabe T et al (2004) NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type-1 responses. Nat Immunol 5:800-808 (Pubitemid 39172973)
    • (2004) Nature Immunology , vol.5 , Issue.8 , pp. 800-808
    • Watanabe, T.1    Kitani, A.2    Murray, P.J.3    Strober, W.4
  • 71
    • 70349468054 scopus 로고    scopus 로고
    • Nod2 is required for the regulation of commensal microbiota in the intestine
    • Petnicki-Ocwieja T et al (2009) Nod2 is required for the regulation of commensal microbiota in the intestine. Proc Natl Acad Sci USA 106:15813-15818
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 15813-15818
    • Petnicki-Ocwieja, T.1
  • 72
    • 80052580369 scopus 로고    scopus 로고
    • Nod2 is essential for temporal development of intestinal microbial communities
    • Rehman A et al. (2011) Nod2 is essential for temporal development of intestinal microbial communities. Gut 60:1354-1362
    • (2011) Gut , vol.60 , pp. 1354-1362
    • Rehman, A.1
  • 74
    • 58149159542 scopus 로고    scopus 로고
    • Common variants in the NLRP3 region contribute to Crohn's disease susceptibility
    • Villani AC et al (2009) Common variants in the NLRP3 region contribute to Crohn's disease susceptibility. Nat Genet 41:71-76
    • (2009) Nat Genet , vol.41 , pp. 71-76
    • Villani, A.C.1
  • 75
    • 79953084107 scopus 로고    scopus 로고
    • The Nlrp3 inflammasome: Contributions to intestinal homeostasis
    • Zaki MH et al (2011) The Nlrp3 inflammasome: contributions to intestinal homeostasis. Trends Immunol 32:171-179
    • (2011) Trends Immunol , vol.32 , pp. 171-179
    • Zaki, M.H.1
  • 76
    • 79955846705 scopus 로고    scopus 로고
    • NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis
    • Hirota SA et al (2011) NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis. Inflamm Bowel Dis 17:1359-1372
    • (2011) Inflamm Bowel Dis , vol.17 , pp. 1359-1372
    • Hirota, S.A.1
  • 77
    • 77950002937 scopus 로고    scopus 로고
    • The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis
    • Zaki MH et al (2010) The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. Immunity 32:379-391
    • (2010) Immunity , vol.32 , pp. 379-391
    • Zaki, M.H.1
  • 78
    • 77949965210 scopus 로고    scopus 로고
    • Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases
    • Dupaul-Chicoine J et al (2010) Control of intestinal homeostasis, colitis, and colitis-associated colorectal cancer by the inflammatory caspases. Immunity 32:367-378
    • (2010) Immunity , vol.32 , pp. 367-378
    • Dupaul-Chicoine, J.1
  • 79
    • 77952303410 scopus 로고    scopus 로고
    • The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer
    • Allen IC et al (2010) The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer. J Exp Med 207:1045-1056
    • (2010) J Exp Med , vol.207 , pp. 1045-1056
    • Allen, I.C.1
  • 80
    • 78650735879 scopus 로고    scopus 로고
    • Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4
    • Hu B et al (2010) Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4. Proc Natl Acad Sci USA 107:21635-21640
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 21635-21640
    • Hu, B.1
  • 81
    • 79952195585 scopus 로고    scopus 로고
    • Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
    • Anderson CA et al (2011) Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet 43:246-252
    • (2011) Nat Genet , vol.43 , pp. 246-252
    • Anderson, C.A.1
  • 82
    • 78651225855 scopus 로고    scopus 로고
    • Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease
    • Momozawa Y et al (2011) Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease. Nat Genet 43:43-47
    • (2011) Nat Genet , vol.43 , pp. 43-47
    • Momozawa, Y.1
  • 85
    • 78751672975 scopus 로고    scopus 로고
    • Autophagy in immunity and inflammation
    • Levine B et al (2011) Autophagy in immunity and inflammation. Nature 469:323-335
    • (2011) Nature , vol.469 , pp. 323-335
    • Levine, B.1
  • 86
    • 37549043217 scopus 로고    scopus 로고
    • Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis
    • Sanjuan MA et al (2007) Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis. Nature 450:1253-1257
    • (2007) Nature , vol.450 , pp. 1253-1257
    • Sanjuan, M.A.1
  • 87
    • 73849151394 scopus 로고    scopus 로고
    • NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation
    • Cooney R et al (2010) NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat Med 16:90-97
    • (2010) Nat Med , vol.16 , pp. 90-97
    • Cooney, R.1
  • 88
    • 77957682295 scopus 로고    scopus 로고
    • ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn's disease pathogenesis
    • 1641 e1-2
    • Homer CR et al (2010) ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn's disease pathogenesis. Gastroenterology 139:1630-1641 1641 e1-2
    • (2010) Gastroenterology , vol.139 , pp. 1630-1641
    • Homer, C.R.1
  • 89
    • 56249135538 scopus 로고    scopus 로고
    • A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
    • Cadwell K et al (2008) A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 456:259-263
    • (2008) Nature , vol.456 , pp. 259-263
    • Cadwell, K.1
  • 90
    • 0025945933 scopus 로고
    • Helicobacter pylori infection and the risk of gastric carcinoma
    • Parsonnet J et al (1991) Helicobacter pylori infection and the risk of gastric carcinoma. N Engl J Med 325:1127-1131
    • (1991) N Engl J Med , vol.325 , pp. 1127-1131
    • Parsonnet, J.1
  • 92
    • 78651564013 scopus 로고    scopus 로고
    • The association of Streptococcus bovis/gallolyticus with colorectal tumors: The nature and the underlying mechanisms of its etiological role
    • Abdulamir AS et al (2011) The association of Streptococcus bovis/gallolyticus with colorectal tumors: the nature and the underlying mechanisms of its etiological role. J Exp Clin Cancer Res 30:11
    • (2011) J Exp Clin Cancer Res , vol.30 , pp. 11
    • Abdulamir, A.S.1
  • 93
    • 34447296425 scopus 로고    scopus 로고
    • Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88
    • DOI 10.1126/science.1140488
    • Rakoff-Nahoum S, Medzhitov R (2007) Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science 317:124-127 (Pubitemid 47056471)
    • (2007) Science , vol.317 , Issue.5834 , pp. 124-127
    • Rakoff-Nahoum, S.1    Medzhitov, R.2
  • 94
    • 67650299380 scopus 로고    scopus 로고
    • Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility
    • Uronis JM et al (2009) Modulation of the intestinal microbiota alters colitis-associated colorectal cancer susceptibility. PLoS One 4:e6026
    • (2009) PLoS One , vol.4
    • Uronis, J.M.1
  • 96
    • 77953196709 scopus 로고    scopus 로고
    • ERK activation drives intestinal tumorigenesis in Apc (min/+) mice
    • Lee SH et al (2010) ERK activation drives intestinal tumorigenesis in Apc (min/+) mice. Nat Med 16:665-670
    • (2010) Nat Med , vol.16 , pp. 665-670
    • Lee, S.H.1
  • 97
  • 98
    • 57749094105 scopus 로고    scopus 로고
    • The innate immune receptor Nod1 protects the intestine from inflammation-induced tumorigenesis
    • Chen GY et al (2008) The innate immune receptor Nod1 protects the intestine from inflammation-induced tumorigenesis. Cancer Res 68:10060-10067
    • (2008) Cancer Res , vol.68 , pp. 10060-10067
    • Chen, G.Y.1
  • 99
    • 77649237093 scopus 로고    scopus 로고
    • Differential effects of NOD2 polymorphisms on colorectal cancer risk: A meta-analysis
    • Tian Y et al (2010) Differential effects of NOD2 polymorphisms on colorectal cancer risk: a meta-analysis. Int J Colorectal Dis 25:161-168
    • (2010) Int J Colorectal Dis , vol.25 , pp. 161-168
    • Tian, Y.1
  • 100
    • 70749146442 scopus 로고    scopus 로고
    • Investigation of innate immunity genes CARD4, CARD8 and CARD15 as germline susceptibility factors for colorectal cancer
    • Mockelmann N et al (2009) Investigation of innate immunity genes CARD4, CARD8 and CARD15 as germline susceptibility factors for colorectal cancer. BMC Gastroenterol 9:79
    • (2009) BMC Gastroenterol , vol.9 , pp. 79
    • Mockelmann, N.1
  • 101
    • 79958178482 scopus 로고    scopus 로고
    • Toll-like receptors in angiogenesis
    • Grote K et al (2011) Toll-like receptors in angiogenesis. Sci World J 11:981-991
    • (2011) Sci World J , vol.11 , pp. 981-991
    • Grote, K.1
  • 103
    • 0030595339 scopus 로고    scopus 로고
    • The dorsoventral regulatory gene cassette spatzle/Toll/Cactus controls the potent antifungal response in Drosophila adults
    • DOI 10.1016/S0092-8674(00)80172-5
    • Lemaitre B et al (1996) The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86:973-983 (Pubitemid 26336801)
    • (1996) Cell , vol.86 , Issue.6 , pp. 973-983
    • Lemaitre, B.1    Nicolas, E.2    Michaut, L.3    Reichhart, J.-M.4    Hoffmann, J.A.5
  • 106
    • 0033120081 scopus 로고    scopus 로고
    • Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide evidence for TLR4 as the Lps gene product
    • Hoshino K et al (1999) Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 162:3749-3752 (Pubitemid 29314747)
    • (1999) Journal of Immunology , vol.162 , Issue.7 , pp. 3749-3752
    • Hoshino, K.1    Takeuchi, O.2    Kawai, T.3    Sanjo, H.4    Ogawa, T.5    Takeda, Y.6    Takeda, K.7    Akira, S.8
  • 108
    • 0035425495 scopus 로고    scopus 로고
    • Innate immune responses of epithelial cells following infection with bacterial pathogens
    • DOI 10.1016/S0952-7915(00)00235-1
    • Philpott DJ et al (2001) Innate immune responses of epithelial cells following infection with bacterial pathogens. Curr Opin Immunol 13:410-416 (Pubitemid 32728473)
    • (2001) Current Opinion in Immunology , vol.13 , Issue.4 , pp. 410-416
    • Philpott, D.J.1    Girardin, S.E.2    Sansonetti, P.J.3
  • 109
    • 62349126241 scopus 로고    scopus 로고
    • A history of recurrent positive selection at the toll-like receptor 5 in primates
    • Wlasiuk G et al (2009) A history of recurrent positive selection at the toll-like receptor 5 in primates. Mol Biol Evol 26:937-949
    • (2009) Mol Biol Evol , vol.26 , pp. 937-949
    • Wlasiuk, G.1
  • 110
    • 33748039462 scopus 로고    scopus 로고
    • Symbiotic bacteria direct expression of an intestinal bactericidal lectin
    • DOI 10.1126/science.1127119
    • Cash HL et al (2006) Symbiotic bacteria direct expression of an intestinal bactericidal lectin. Science 313:1126-1130 (Pubitemid 44300239)
    • (2006) Science , vol.313 , Issue.5790 , pp. 1126-1130
    • Cash, H.L.1    Whitham, C.V.2    Behrendt, C.L.3    Hooper, L.V.4
  • 111
    • 34547762705 scopus 로고    scopus 로고
    • MyD88-mediated signals induce the bactericidal lectin RegIIIγ and protect mice against intestinal Listeria monocytogenes infection
    • DOI 10.1084/jem.20070563
    • Brandl K et al (2007) MyD88-mediated signals induce the bactericidal lectin RegIII gamma and protect mice against intestinal Listeria monocytogenes infection. J Exp Med 204:1891-1900 (Pubitemid 47236324)
    • (2007) Journal of Experimental Medicine , vol.204 , Issue.8 , pp. 1891-1900
    • Brandl, K.1    Plitas, G.2    Schnabl, B.3    DeMatteo, R.P.4    Pamer, E.G.5
  • 112
    • 53649098280 scopus 로고    scopus 로고
    • Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits
    • Brandl K et al (2008) Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits. Nature 455:804-807
    • (2008) Nature , vol.455 , pp. 804-807
    • Brandl, K.1
  • 113
    • 75749133608 scopus 로고    scopus 로고
    • Bacterial flagellin stimulates Tolllike receptor 5-dependent defense against vancomycin-resistant Enterococcus infection
    • Kinnebrew MA et al (2010) Bacterial flagellin stimulates Tolllike receptor 5-dependent defense against vancomycin-resistant Enterococcus infection. J Infect Dis 201:534-543
    • (2010) J Infect Dis , vol.201 , pp. 534-543
    • Kinnebrew, M.A.1
  • 114
    • 79953300500 scopus 로고    scopus 로고
    • Toll-like receptor 5 stimulation protects mice from acute Clostridium difficile colitis
    • Jarchum I et al (2011) Toll-like receptor 5 stimulation protects mice from acute Clostridium difficile colitis. Infect Immun 79:1498-1503
    • (2011) Infect Immun , vol.79 , pp. 1498-1503
    • Jarchum, I.1
  • 115
    • 40749097296 scopus 로고    scopus 로고
    • Toll-like receptor 5-deficient mice have dysregulated intestinal gene expression and nonspecific resistance to Salmonella-induced typhoid-like disease
    • DOI 10.1128/IAI.01491-07
    • Vijay-Kumar M et al (2008) Toll-like receptor 5-deficient mice have dysregulated intestinal gene expression and nonspecific resistance to Salmonella-induced typhoid-like disease. Infect Immun 76:1276-1281 (Pubitemid 351428091)
    • (2008) Infection and Immunity , vol.76 , Issue.3 , pp. 1276-1281
    • Vijay-Kumar, M.1    Aitken, J.D.2    Kumar, A.3    Neish, A.S.4    Uematsu, S.5    Akira, S.6    Gewirtz, A.T.7
  • 118
    • 50949098448 scopus 로고    scopus 로고
    • Nod2 mediates susceptibility to Yersinia pseudotuberculosis in mice
    • Meinzer U et al (2008) Nod2 mediates susceptibility to Yersinia pseudotuberculosis in mice. PLoS One 3:e2769
    • (2008) PLoS One , vol.3
    • Meinzer, U.1
  • 119
    • 77957047689 scopus 로고    scopus 로고
    • Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum
    • Biswas A et al (2010) Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum. Proc Natl Acad Sci USA 107:14739-14744
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 14739-14744
    • Biswas, A.1
  • 121
    • 77951784552 scopus 로고    scopus 로고
    • NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type-I IFN and activation of the ISGF3 signaling pathway
    • Watanabe T et al (2010) NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type-I IFN and activation of the ISGF3 signaling pathway. J Clin Invest 120:1645-1662
    • (2010) J Clin Invest , vol.120 , pp. 1645-1662
    • Watanabe, T.1
  • 123
    • 77954332543 scopus 로고    scopus 로고
    • The innate immune molecule, NOD1, regulates direct killing of Helicobacter pylori by antimicrobial peptides
    • Grubman A et al (2010) The innate immune molecule, NOD1, regulates direct killing of Helicobacter pylori by antimicrobial peptides. Cell Microbiol 12:626-639
    • (2010) Cell Microbiol , vol.12 , pp. 626-639
    • Grubman, A.1
  • 124
    • 79955048935 scopus 로고    scopus 로고
    • Nucleotide-binding oligomerization domain 1 mediates recognition of Clostridium difficile and induces neutrophil recruitment and protection against the pathogen
    • Hasegawa M et al (2011) Nucleotide-binding oligomerization domain 1 mediates recognition of Clostridium difficile and induces neutrophil recruitment and protection against the pathogen. J Immunol 186:4872-4880
    • (2011) J Immunol , vol.186 , pp. 4872-4880
    • Hasegawa, M.1
  • 125
    • 31944437924 scopus 로고    scopus 로고
    • Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo
    • Masumoto J et al (2006) Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo. J Exp Med 203:203-213
    • (2006) J Exp Med , vol.203 , pp. 203-213
    • Masumoto, J.1
  • 126
    • 76249120134 scopus 로고    scopus 로고
    • Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity
    • Clarke TB et al (2010) Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity. Nat Med 16:228-231
    • (2010) Nat Med , vol.16 , pp. 228-231
    • Clarke, T.B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.