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Volumn 8, Issue 4, 2011, Pages 577-590

Cellular Therapy and Induced Neuronal Replacement for Huntington's Disease

Author keywords

Cell therapy; Medium spiny neuron; Neural transplants; Neurogenesis; Stem cells

Indexed keywords

BONE MORPHOGENETIC PROTEIN; HUNTINGTIN; POLYGLUTAMINE;

EID: 80955131284     PISSN: 19337213     EISSN: 18787479     Source Type: Journal    
DOI: 10.1007/s13311-011-0075-8     Document Type: Review
Times cited : (52)

References (149)
  • 1
    • 0029011778 scopus 로고
    • Rationale for intrastriatal grafting of striatal neuroblasts in patients with Huntington's disease
    • Peschanski M, Cesaro P, Hantraye P. Rationale for intrastriatal grafting of striatal neuroblasts in patients with Huntington's disease. Neuroscience 1995; 68: 273-285.
    • (1995) Neuroscience , vol.68 , pp. 273-285
    • Peschanski, M.1    Cesaro, P.2    Hantraye, P.3
  • 2
    • 36248951526 scopus 로고    scopus 로고
    • Reduced activity of cortico-striatal fibres in the R6/2 mouse model of Huntington's disease
    • Traficante A, Riozzi B, Cannella M, Rampello L, Squitieri F, Battaglia G. Reduced activity of cortico-striatal fibres in the R6/2 mouse model of Huntington's disease. Neuroreport 2007; 18: 1997-2000.
    • (2007) Neuroreport , vol.18 , pp. 1997-2000
    • Traficante, A.1    Riozzi, B.2    Cannella, M.3    Rampello, L.4    Squitieri, F.5    Battaglia, G.6
  • 3
    • 3142636768 scopus 로고    scopus 로고
    • Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules
    • Gauthier LR, Charrin BC, Borrell-Pages M, et al. Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules. Cell 2004; 118: 127-138.
    • (2004) Cell , vol.118 , pp. 127-138
    • Gauthier, L.R.1    Charrin, B.C.2    Borrell-Pages, M.3
  • 4
    • 0031887047 scopus 로고    scopus 로고
    • Safety of intrastriatal neurotransplantation for Huntington's disease patients
    • Kopyov OV, Jacques S, Lieberman A, Duma CM, Eagle KS. Safety of intrastriatal neurotransplantation for Huntington's disease patients. Exp Neurol 1998; 149: 97-108.
    • (1998) Exp Neurol , vol.149 , pp. 97-108
    • Kopyov, O.V.1    Jacques, S.2    Lieberman, A.3    Duma, C.M.4    Eagle, K.S.5
  • 5
    • 0030029924 scopus 로고    scopus 로고
    • Transplantation of human striatal tissue into a rodent model of Huntington's disease: phenotypic expression of transplanted neurons and host-to-graft innervation
    • Pundt LL, Kondoh T, Conrad JA, Low WC. Transplantation of human striatal tissue into a rodent model of Huntington's disease: phenotypic expression of transplanted neurons and host-to-graft innervation. Brain Res Bull 1996; 39: 23-32.
    • (1996) Brain Res Bull , vol.39 , pp. 23-32
    • Pundt, L.L.1    Kondoh, T.2    Conrad, J.A.3    Low, W.C.4
  • 6
    • 0031944834 scopus 로고    scopus 로고
    • Bilateral fetal striatal grafts in the 3-nitropropionic acid-induced hypoactive model of Huntington's disease
    • Borlongan CV, Koutouzis TK, Poulos SG, Saporta S, Sanberg PR. Bilateral fetal striatal grafts in the 3-nitropropionic acid-induced hypoactive model of Huntington's disease. Cell Transplant 1998; 7: 131-135.
    • (1998) Cell Transplant , vol.7 , pp. 131-135
    • Borlongan, C.V.1    Koutouzis, T.K.2    Poulos, S.G.3    Saporta, S.4    Sanberg, P.R.5
  • 7
    • 0036457016 scopus 로고    scopus 로고
    • Neural cells from primary human striatal xenografts migrate extensively in the adult rat CNS
    • Hurelbrink CB, Armstrong RJ, Dunnett SB, Rosser AE, Barker RA. Neural cells from primary human striatal xenografts migrate extensively in the adult rat CNS. Eur J Neurosci 2002; 15: 1255-1266.
    • (2002) Eur J Neurosci , vol.15 , pp. 1255-1266
    • Hurelbrink, C.B.1    Armstrong, R.J.2    Dunnett, S.B.3    Rosser, A.E.4    Barker, R.A.5
  • 8
    • 0024398330 scopus 로고
    • Intrinsic Organization and connectivity of intrastriatal striatal transplants in rats as revealed by DARPP-32 immunohistochemistry: specificity of connections with the lesioned host brain
    • Wictorin K, Ouimet CC, Bjorklund A. Intrinsic Organization and connectivity of intrastriatal striatal transplants in rats as revealed by DARPP-32 immunohistochemistry: specificity of connections with the lesioned host brain. Eur J Neurosci 1989; 1: 690-701.
    • (1989) Eur J Neurosci , vol.1 , pp. 690-701
    • Wictorin, K.1    Ouimet, C.C.2    Bjorklund, A.3
  • 9
    • 0031902287 scopus 로고    scopus 로고
    • Fetal striatal allografts reverse cognitive deficits in a primate model of Huntington disease
    • Palfi S, Conde F, Riche D, et al. Fetal striatal allografts reverse cognitive deficits in a primate model of Huntington disease. Nat Med 1998; 4: 963-966.
    • (1998) Nat Med , vol.4 , pp. 963-966
    • Palfi, S.1    Conde, F.2    Riche, D.3
  • 10
    • 0034627143 scopus 로고    scopus 로고
    • Motor and cognitive improvements in patients with Huntington's disease after neural transplantation
    • Bachoud-Levi AC, Remy P, Nguyen JP, et al. Motor and cognitive improvements in patients with Huntington's disease after neural transplantation. Lancet 2000; 356: 1975-1979.
    • (2000) Lancet , vol.356 , pp. 1975-1979
    • Bachoud-Levi, A.C.1    Remy, P.2    Nguyen, J.P.3
  • 11
    • 9144221004 scopus 로고    scopus 로고
    • Striatal neural grafting improves cortical metabolism in Huntington's disease patients
    • Gaura V, Bachoud-Levi AC, Ribeiro MJ, et al. Striatal neural grafting improves cortical metabolism in Huntington's disease patients. Brain 2004; 127(part 1): 65-72.
    • (2004) Brain , vol.127 , Issue.PART. 1 , pp. 65-72
    • Gaura, V.1    Bachoud-Levi, A.C.2    Ribeiro, M.J.3
  • 12
    • 33644967927 scopus 로고    scopus 로고
    • Effect of fetal neural transplants in patients with Huntington's disease 6 years after surgery: a long-term follow-up study
    • Bachoud-Levi AC, Gaura V, Brugieres P, et al. Effect of fetal neural transplants in patients with Huntington's disease 6 years after surgery: a long-term follow-up study. Lancet Neurol 2006; 5: 303-309.
    • (2006) Lancet Neurol , vol.5 , pp. 303-309
    • Bachoud-Levi, A.C.1    Gaura, V.2    Brugieres, P.3
  • 13
    • 0037066096 scopus 로고    scopus 로고
    • Bilateral human fetal striatal transplantation in Huntington's disease
    • Hauser RA, Furtado S, Cimino CR, et al. Bilateral human fetal striatal transplantation in Huntington's disease. Neurology 2002; 58: 687-695.
    • (2002) Neurology , vol.58 , pp. 687-695
    • Hauser, R.A.1    Furtado, S.2    Cimino, C.R.3
  • 14
    • 23244461696 scopus 로고    scopus 로고
    • Positron emission tomography after fetal transplantation in Huntington's disease
    • Furtado S, Sossi V, Hauser RA, et al. Positron emission tomography after fetal transplantation in Huntington's disease. Ann Neurol 2005; 58: 331-337.
    • (2005) Ann Neurol , vol.58 , pp. 331-337
    • Furtado, S.1    Sossi, V.2    Hauser, R.A.3
  • 15
    • 79952163901 scopus 로고    scopus 로고
    • Neuronal degeneration in striatal transplants and Huntington's disease: Potential mechanisms and clinical implications
    • Cicchetti F, Soulet D, Freeman TB. Neuronal degeneration in striatal transplants and Huntington's disease: potential mechanisms and clinical implications. Brain 2011; 134(part 3): 641-652.
    • (2011) Brain , vol.134 , Issue.PART. 3 , pp. 641-652
    • Cicchetti, F.1    Soulet, D.2    Freeman, T.B.3
  • 16
    • 0036904801 scopus 로고    scopus 로고
    • Unilateral transplantation of human primary fetal tissue in four patients with Huntington's disease: NEST-UK safety report ISRCTN no 36485475
    • Rosser AE, Barker RA, Harrower T, et al. Unilateral transplantation of human primary fetal tissue in four patients with Huntington's disease: NEST-UK safety report ISRCTN no 36485475. J Neurol Neurosurg Psychiatry 2002; 73: 678-685.
    • (2002) J Neurol Neurosurg Psychiatry , vol.73 , pp. 678-685
    • Rosser, A.E.1    Barker, R.A.2    Harrower, T.3
  • 17
    • 33847673272 scopus 로고    scopus 로고
    • Cell transplantation for Huntington's disease Should we continue?
    • Dunnett SB, Rosser AE. Cell transplantation for Huntington's disease Should we continue? Brain Res Bull 2007; 72: 132-147.
    • (2007) Brain Res Bull , vol.72 , pp. 132-147
    • Dunnett, S.B.1    Rosser, A.E.2
  • 18
    • 48249145755 scopus 로고    scopus 로고
    • Long-term clinical and positron emission tomography outcome of fetal striatal transplantation in Huntington's disease
    • Reuter I, Tai YF, Pavese N, et al. Long-term clinical and positron emission tomography outcome of fetal striatal transplantation in Huntington's disease. J Neurol Neurosurg Psychiatry 2008; 79: 948-951.
    • (2008) J Neurol Neurosurg Psychiatry , vol.79 , pp. 948-951
    • Reuter, I.1    Tai, Y.F.2    Pavese, N.3
  • 19
    • 64449085619 scopus 로고    scopus 로고
    • Histological findings on fetal striatal grafts in a Huntington's disease patient early after transplantation
    • Capetian P, Knoth R, Maciaczyk J, et al. Histological findings on fetal striatal grafts in a Huntington's disease patient early after transplantation. Neuroscience 2009; 160: 661-675.
    • (2009) Neuroscience , vol.160 , pp. 661-675
    • Capetian, P.1    Knoth, R.2    Maciaczyk, J.3
  • 20
    • 77649338570 scopus 로고    scopus 로고
    • Human striatal neuroblasts develop and build a striatal-like structure into the brain of Huntington's disease patients after transplantation
    • Gallina P, Paganini M, Lombardini L, et al. Human striatal neuroblasts develop and build a striatal-like structure into the brain of Huntington's disease patients after transplantation. Exp Neurol 2010; 222: 30-41.
    • (2010) Exp Neurol , vol.222 , pp. 30-41
    • Gallina, P.1    Paganini, M.2    Lombardini, L.3
  • 21
    • 0030964773 scopus 로고    scopus 로고
    • Neostriatal cell subtypes and their functional roles
    • Kawaguchi Y. Neostriatal cell subtypes and their functional roles. Neurosci Res 1997; 27: 1-8.
    • (1997) Neurosci Res , vol.27 , pp. 1-8
    • Kawaguchi, Y.1
  • 22
    • 0028341247 scopus 로고
    • Three distinct subpopulations of GABAergic neurons in rat frontal agranular cortex
    • Kubota Y, Hattori R, Yui Y. Three distinct subpopulations of GABAergic neurons in rat frontal agranular cortex. Brain Res 1994; 649: 159-173.
    • (1994) Brain Res , vol.649 , pp. 159-173
    • Kubota, Y.1    Hattori, R.2    Yui, Y.3
  • 23
    • 55249107197 scopus 로고    scopus 로고
    • Alloimmunisation to donor antigens and immune rejection following foetal neural grafts to the brain in patients with Huntington's disease
    • Krystkowiak P, Gaura V, Labalette M, et al. Alloimmunisation to donor antigens and immune rejection following foetal neural grafts to the brain in patients with Huntington's disease. PLoS One 2007; 2: e166.
    • (2007) PLoS One , vol.2
    • Krystkowiak, P.1    Gaura, V.2    Labalette, M.3
  • 24
    • 0027724863 scopus 로고
    • Increased proportion of acetylcholinesterase-rich zones and improved morphological integration in host striatum of fetal grafts derived from the lateral but not the medial ganglionic eminence
    • Pakzaban P, Deacon TW, Burns LH, Isacson O. Increased proportion of acetylcholinesterase-rich zones and improved morphological integration in host striatum of fetal grafts derived from the lateral but not the medial ganglionic eminence. Exp Brain Res 1993; 97: 13-22.
    • (1993) Exp Brain Res , vol.97 , pp. 13-22
    • Pakzaban, P.1    Deacon, T.W.2    Burns, L.H.3    Isacson, O.4
  • 25
    • 0034064954 scopus 로고    scopus 로고
    • Embryonic donor age and dissection influences striatal graft development and functional integration in a rodent model of Huntington's disease
    • Watts C, Brasted PJ, Dunnett SB. Embryonic donor age and dissection influences striatal graft development and functional integration in a rodent model of Huntington's disease. Exp Neurol 2000; 163: 85-97.
    • (2000) Exp Neurol , vol.163 , pp. 85-97
    • Watts, C.1    Brasted, P.J.2    Dunnett, S.B.3
  • 26
    • 68149168120 scopus 로고    scopus 로고
    • Neural transplants in patients with Huntington's disease undergo disease-like neuronal degeneration
    • Cicchetti F, Saporta S, Hauser RA, et al. Neural transplants in patients with Huntington's disease undergo disease-like neuronal degeneration. Proc Natl Acad Sci U S A 2009; 106: 12483-12488.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 12483-12488
    • Cicchetti, F.1    Saporta, S.2    Hauser, R.A.3
  • 28
    • 21944446706 scopus 로고    scopus 로고
    • Histological analysis of fetal dopamine cell suspension grafts in two patients with Parkinson's disease gives promising results
    • Kirik D, Bjorklund A. Histological analysis of fetal dopamine cell suspension grafts in two patients with Parkinson's disease gives promising results. Brain 2005; 128(part 7): 1478-1479.
    • (2005) Brain , vol.128 , Issue.PART. 7 , pp. 1478-1479
    • Kirik, D.1    Bjorklund, A.2
  • 29
    • 0033838272 scopus 로고    scopus 로고
    • The morphology, integration, and functional efficacy of striatal grafts differ between cell suspensions and tissue pieces
    • Watts C, Brasted PJ, Dunnett SB. The morphology, integration, and functional efficacy of striatal grafts differ between cell suspensions and tissue pieces. Cell Transplant 2000; 9: 395-407.
    • (2000) Cell Transplant , vol.9 , pp. 395-407
    • Watts, C.1    Brasted, P.J.2    Dunnett, S.B.3
  • 30
    • 43249114934 scopus 로고    scopus 로고
    • Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease
    • Kordower JH, Chu Y, Hauser RA, Freeman TB, Olanow CW. Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease. Nat Med 2008; 14: 504-506.
    • (2008) Nat Med , vol.14 , pp. 504-506
    • Kordower, J.H.1    Chu, Y.2    Hauser, R.A.3    Freeman, T.B.4    Olanow, C.W.5
  • 31
    • 0028868574 scopus 로고
    • Transplanted xenogeneic neural cells in neurodegenerative disease models exhibit remarkable axonal target specificity and distinct growth patterns of glial and axonal fibres
    • Isacson O, Deacon TW, Pakzaban P, Galpern WR, Dinsmore J, Burns LH. Transplanted xenogeneic neural cells in neurodegenerative disease models exhibit remarkable axonal target specificity and distinct growth patterns of glial and axonal fibres. Nat Med 1995; 1: 1189-1194.
    • (1995) Nat Med , vol.1 , pp. 1189-1194
    • Isacson, O.1    Deacon, T.W.2    Pakzaban, P.3    Galpern, W.R.4    Dinsmore, J.5    Burns, L.H.6
  • 32
    • 21944436225 scopus 로고    scopus 로고
    • Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease
    • Mendez I, Sanchez-Pernaute R, Cooper O, et al. Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease. Brain 2005; 128(part 7): 1498-1510.
    • (2005) Brain , vol.128 , Issue.PART. 7 , pp. 1498-1510
    • Mendez, I.1    Sanchez-Pernaute, R.2    Cooper, O.3
  • 34
    • 0030271245 scopus 로고    scopus 로고
    • DARPP-32-rich zones in grafts of lateral ganglionic eminence govern the extent of functional recovery in skilled paw reaching in an animal model of Huntington's disease
    • Nakao N, Grasbon-Frodl EM, Widner H, Brundin P. DARPP-32-rich zones in grafts of lateral ganglionic eminence govern the extent of functional recovery in skilled paw reaching in an animal model of Huntington's disease. Neuroscience 1996; 74: 959-970.
    • (1996) Neuroscience , vol.74 , pp. 959-970
    • Nakao, N.1    Grasbon-Frodl, E.M.2    Widner, H.3    Brundin, P.4
  • 35
    • 0033952471 scopus 로고    scopus 로고
    • Promoter-based isolation and fluorescence-activated sorting of mitotic neuronal progenitor cells from the adult mammalian ependymal/subependymal zone
    • Wang S, Roy NS, Benraiss A, Goldman SA. Promoter-based isolation and fluorescence-activated sorting of mitotic neuronal progenitor cells from the adult mammalian ependymal/subependymal zone. Dev Neurosci 2000; 22: 167-176.
    • (2000) Dev Neurosci , vol.22 , pp. 167-176
    • Wang, S.1    Roy, N.S.2    Benraiss, A.3    Goldman, S.A.4
  • 36
    • 0034869475 scopus 로고    scopus 로고
    • High-yield selection and extraction of two promoter-defined phenotypes of neural stem cells from the fetal human brain
    • Keyoung HM, Roy NS, Benraiss A, et al. High-yield selection and extraction of two promoter-defined phenotypes of neural stem cells from the fetal human brain. Nat Biotechnol 2001; 19: 843-850.
    • (2001) Nat Biotechnol , vol.19 , pp. 843-850
    • Keyoung, H.M.1    Roy, N.S.2    Benraiss, A.3
  • 37
    • 78049516954 scopus 로고    scopus 로고
    • Prospective identification, isolation, and profiling of a telomerase-expressing subpopulation of human neural stem cells, using sox2 enhancer-directed fluorescence-activated cell sorting
    • Wang S, Chandler-Militello D, Lu G, et al. Prospective identification, isolation, and profiling of a telomerase-expressing subpopulation of human neural stem cells, using sox2 enhancer-directed fluorescence-activated cell sorting. J Neurosci 2010; 30: 14635-14648.
    • (2010) J Neurosci , vol.30 , pp. 14635-14648
    • Wang, S.1    Chandler-Militello, D.2    Lu, G.3
  • 38
    • 1542336187 scopus 로고    scopus 로고
    • Fetal and adult human oligodendrocyte progenitor cell isolates myelinate the congenitally dysmyelinated brain
    • Windrem MS, Nunes MC, Rashbaum WK, et al. Fetal and adult human oligodendrocyte progenitor cell isolates myelinate the congenitally dysmyelinated brain. Nat Med 2004; 10: 93-97.
    • (2004) Nat Med , vol.10 , pp. 93-97
    • Windrem, M.S.1    Nunes, M.C.2    Rashbaum, W.K.3
  • 39
    • 0037106148 scopus 로고    scopus 로고
    • Progenitor cells derived from the adult human subcortical white matter disperse and differentiate as oligodendrocytes within demyelinated lesions of the rat brain
    • Windrem MS, Roy NS, Wang J, et al. Progenitor cells derived from the adult human subcortical white matter disperse and differentiate as oligodendrocytes within demyelinated lesions of the rat brain. J Neurosci Res 2002; 69: 966-975.
    • (2002) J Neurosci Res , vol.69 , pp. 966-975
    • Windrem, M.S.1    Roy, N.S.2    Wang, J.3
  • 40
    • 55949130712 scopus 로고    scopus 로고
    • Striatal progenitors derived from human ES cells mature into DARPP32 neurons in vitro and in quinolinic acid-lesioned rats
    • Aubry L, Bugi A, Lefort N, Rousseau F, Peschanski M, Perrier AL. Striatal progenitors derived from human ES cells mature into DARPP32 neurons in vitro and in quinolinic acid-lesioned rats. Proc Natl Acad Sci USA 2008; 105: 16707-16712.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 16707-16712
    • Aubry, L.1    Bugi, A.2    Lefort, N.3    Rousseau, F.4    Peschanski, M.5    Perrier, A.L.6
  • 41
    • 33750706917 scopus 로고    scopus 로고
    • Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes
    • Roy NS, Cleren C, Singh SK, Yang L, Beal MF, Goldman SA. Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes. Nat Med 2006; 12: 1259-1268.
    • (2006) Nat Med , vol.12 , pp. 1259-1268
    • Roy, N.S.1    Cleren, C.2    Singh, S.K.3    Yang, L.4    Beal, M.F.5    Goldman, S.A.6
  • 42
    • 0037133163 scopus 로고    scopus 로고
    • Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model
    • Bjorklund LM, Sanchez-Pernaute R, Chung S, et al. Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proc Natl Acad Sci U S A 2002; 99: 2344-2349.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 2344-2349
    • Bjorklund, L.M.1    Sanchez-Pernaute, R.2    Chung, S.3
  • 43
    • 10744229091 scopus 로고    scopus 로고
    • Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice
    • Barberi T, Klivenyi P, Calingasan NY, et al. Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice. Nat Biotechnol 2003; 21: 1200-1207.
    • (2003) Nat Biotechnol , vol.21 , pp. 1200-1207
    • Barberi, T.1    Klivenyi, P.2    Calingasan, N.Y.3
  • 44
    • 0037678426 scopus 로고    scopus 로고
    • et al Host-dependent tumorigenesis of embryonic stem cell transplantation in experimental stroke
    • Erdo F, Buhrle C, Blunk J, et al Host-dependent tumorigenesis of embryonic stem cell transplantation in experimental stroke. J Cereb Blood Flow Metab 2003; 23: 780-785.
    • (2003) J Cereb Blood Flow Metab , vol.23 , pp. 780-785
    • Erdo, F.1    Buhrle, C.2    Blunk, J.3
  • 45
    • 33745542454 scopus 로고    scopus 로고
    • Transplantation of human embryonic stem cell-derived cells to a rat model of Parkinson's disease: effect of in vitro differentiation on graft survival and teratoma formation
    • Brederlau A, Correia AS, Anisimov SV, et al. Transplantation of human embryonic stem cell-derived cells to a rat model of Parkinson's disease: effect of in vitro differentiation on graft survival and teratoma formation. Stem Cells 2006; 24: 1433-1440.
    • (2006) Stem Cells , vol.24 , pp. 1433-1440
    • Brederlau, A.1    Correia, A.S.2    Anisimov, S.V.3
  • 46
    • 70349880527 scopus 로고    scopus 로고
    • Conditions for tumor-free and dopamine neuron-enriched grafts after transplanting human ES cell-derived neural precursor cells
    • Ko JY, Lee HS, Park CH, Koh HC, Lee YS, Lee SH. Conditions for tumor-free and dopamine neuron-enriched grafts after transplanting human ES cell-derived neural precursor cells. Mol Ther 2009; 17: 1761-1770.
    • (2009) Mol Ther , vol.17 , pp. 1761-1770
    • Ko, J.Y.1    Lee, H.S.2    Park, C.H.3    Koh, H.C.4    Lee, Y.S.5    Lee, S.H.6
  • 47
    • 10444252732 scopus 로고    scopus 로고
    • Transplantation of human embryonic stem cell-derived neural progenitors improves behavioral deficit in Parkinsonian rats
    • Ben-Hur T, Idelson M, Khaner H, et al. Transplantation of human embryonic stem cell-derived neural progenitors improves behavioral deficit in Parkinsonian rats. Stem Cells 2004; 22: 1246-1255.
    • (2004) Stem Cells , vol.22 , pp. 1246-1255
    • Ben-Hur, T.1    Idelson, M.2    Khaner, H.3
  • 48
    • 23844510825 scopus 로고    scopus 로고
    • Long-term survival of dopamine neurons derived from parthenogenetic primate embryonic stem cells (cyno-1) after transplantation
    • Sanchez-Pernaute R, Studer L, Ferrari D, et al. Long-term survival of dopamine neurons derived from parthenogenetic primate embryonic stem cells (cyno-1) after transplantation. Stem Cells 2005; 23: 914-922.
    • (2005) Stem Cells , vol.23 , pp. 914-922
    • Sanchez-Pernaute, R.1    Studer, L.2    Ferrari, D.3
  • 49
    • 0036244901 scopus 로고    scopus 로고
    • Surface antigens of human embryonic stem cells: Changes upon differentiation in culture
    • Draper JS, Pigott C, Thomson JA, Andrews PW. Surface antigens of human embryonic stem cells: changes upon differentiation in culture. J Anat 2002; 200(part 3): 249-258.
    • (2002) J Anat , vol.200 , Issue.PART. 3 , pp. 249-258
    • Draper, J.S.1    Pigott, C.2    Thomson, J.A.3    Andrews, P.W.4
  • 50
    • 0037162551 scopus 로고    scopus 로고
    • Characterization of the expression of MHC proteins in human embryonic stem cells
    • Drukker M, Katz G, Urbach A, et al. Characterization of the expression of MHC proteins in human embryonic stem cells. Proc Natl Acad Sci U S A 2002; 99: 9864-9869.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 9864-9869
    • Drukker, M.1    Katz, G.2    Urbach, A.3
  • 51
    • 1242338093 scopus 로고    scopus 로고
    • The immunogenicity of human embryonic stem-derived cells
    • Drukker M, Benvenisty N. The immunogenicity of human embryonic stem-derived cells. Trends Biotechnol 2004; 22: 136-141.
    • (2004) Trends Biotechnol , vol.22 , pp. 136-141
    • Drukker, M.1    Benvenisty, N.2
  • 52
    • 48249137783 scopus 로고    scopus 로고
    • Immune or inflammatory response by the host brain suppresses neuronal differentiation of transplanted ES cell-derived neural precursor cells
    • Ideguchi M, Shinoyama M, Gomi M, Hayashi H, Hashimoto N, Takahashi J. Immune or inflammatory response by the host brain suppresses neuronal differentiation of transplanted ES cell-derived neural precursor cells. J Neurosci Res 2008; 86: 1936-1943.
    • (2008) J Neurosci Res , vol.86 , pp. 1936-1943
    • Ideguchi, M.1    Shinoyama, M.2    Gomi, M.3    Hayashi, H.4    Hashimoto, N.5    Takahashi, J.6
  • 53
    • 36749043230 scopus 로고    scopus 로고
    • Induced pluripotent stem cell lines derived from human somatic cells
    • Yu J, Vodyanik MA, Smuga-Otto K, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007; 318: 1917-1920.
    • (2007) Science , vol.318 , pp. 1917-1920
    • Yu, J.1    Vodyanik, M.A.2    Smuga-Otto, K.3
  • 54
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi K, Tanabe K, Ohnuki M, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007; 131: 861-872.
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3
  • 55
    • 66049143859 scopus 로고    scopus 로고
    • Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins
    • Kim D, Kim CH, Moon JI, et al. Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins. Cell Stem Cell 2009; 4: 472-476.
    • (2009) Cell Stem Cell , vol.4 , pp. 472-476
    • Kim, D.1    Kim, C.H.2    Moon, J.I.3
  • 56
    • 78651295041 scopus 로고    scopus 로고
    • Embryonic stem cell neurogenesis and neural specification
    • Germain N, Banda E, Grabel L. Embryonic stem cell neurogenesis and neural specification. J Cell Biochem 2010; 111: 535-542.
    • (2010) J Cell Biochem , vol.111 , pp. 535-542
    • Germain, N.1    Banda, E.2    Grabel, L.3
  • 57
    • 79957807595 scopus 로고    scopus 로고
    • Immunogenicity of induced pluripotent stem cells
    • Zhao T, Zhang ZN, Rong Z, Xu Y. Immunogenicity of induced pluripotent stem cells. Nature 2011; 474: 212-215.
    • (2011) Nature , vol.474 , pp. 212-215
    • Zhao, T.1    Zhang, Z.N.2    Rong, Z.3    Xu, Y.4
  • 58
    • 60549101977 scopus 로고    scopus 로고
    • Disease-specific induced pluripotent stem cells
    • Beyene R, Boockvar JA. Disease-specific induced pluripotent stem cells. Neurosurgery 2008; 63: 12.
    • (2008) Neurosurgery , vol.63 , pp. 12
    • Beyene, R.1    Boockvar, J.A.2
  • 59
    • 50549089957 scopus 로고    scopus 로고
    • Disease-specific induced pluripotent stem cells
    • Park IH, Arora N, Huo H, et al. Disease-specific induced pluripotent stem cells. Cell 2008; 134: 877-886.
    • (2008) Cell , vol.134 , pp. 877-886
    • Park, I.H.1    Arora, N.2    Huo, H.3
  • 60
    • 84873337576 scopus 로고    scopus 로고
    • Characterization of Human huntington's disease cell model from induced pluripotent stem cells
    • Zhang N, An MC, Montoro D, Ellerby LM. Characterization of Human huntington's disease cell model from induced pluripotent stem cells. PLoS Curr 2010; 2: RRN1193.
    • (2010) PLoS Curr , vol.2
    • Zhang, N.1    An, M.C.2    Montoro, D.3    Ellerby, L.M.4
  • 61
    • 77953623111 scopus 로고    scopus 로고
    • Stem cell model of spinal muscular atrophy
    • Ebert AD, Svendsen CN. Stem cell model of spinal muscular atrophy. Arch Neurol 2010; 67: 665-669.
    • (2010) Arch Neurol , vol.67 , pp. 665-669
    • Ebert, A.D.1    Svendsen, C.N.2
  • 62
    • 42649130264 scopus 로고    scopus 로고
    • Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease
    • Wernig M, Zhao JP, Pruszak J, et al. Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proc Natl Acad Sci U S A 2008; 105: 5856-5861.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 5856-5861
    • Wernig, M.1    Zhao, J.P.2    Pruszak, J.3
  • 63
    • 77957670482 scopus 로고    scopus 로고
    • Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats
    • Hargus G, Cooper O, Deleidi M, et al. Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats. Proc Natl Acad Sci U S A 2010; 107: 15921-15926.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 15921-15926
    • Hargus, G.1    Cooper, O.2    Deleidi, M.3
  • 64
    • 79952126043 scopus 로고    scopus 로고
    • Copy number variation and selection during reprogramming to pluripotency
    • Hussein SM, Batada NN, Vuoristo S, et al. Copy number variation and selection during reprogramming to pluripotency. Nature 2011; 471: 58-62.
    • (2011) Nature , vol.471 , pp. 58-62
    • Hussein, S.M.1    Batada, N.N.2    Vuoristo, S.3
  • 65
    • 79952258224 scopus 로고    scopus 로고
    • Somatic coding mutations in human induced pluripotent stem cells
    • Gore A, Li Z, Fung HL, et al. Somatic coding mutations in human induced pluripotent stem cells. Nature 2011; 471: 63-67.
    • (2011) Nature , vol.471 , pp. 63-67
    • Gore, A.1    Li, Z.2    Fung, H.L.3
  • 66
    • 79952264847 scopus 로고    scopus 로고
    • Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells
    • Lister R, Pelizzola M, Kida YS, et al. Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells. Nature 2011; 471: 68-73.
    • (2011) Nature , vol.471 , pp. 68-73
    • Lister, R.1    Pelizzola, M.2    Kida, Y.S.3
  • 67
    • 0027291286 scopus 로고
    • Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone
    • Luskin MB. Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. Neuron 1993; 11: 173-189.
    • (1993) Neuron , vol.11 , pp. 173-189
    • Luskin, M.B.1
  • 68
    • 0028361594 scopus 로고
    • Long-distance neuronal migration in the adult mammalian brain
    • Lois C, Alvarez-Buylla A. Long-distance neuronal migration in the adult mammalian brain. Science 1994; 264: 1145-1148.
    • (1994) Science , vol.264 , pp. 1145-1148
    • Lois, C.1    Alvarez-Buylla, A.2
  • 70
    • 0029855989 scopus 로고    scopus 로고
    • Network of tangential pathways for neuronal migration in adult mammalian brain
    • Doetsch F, Alvarez-Buylla A. Network of tangential pathways for neuronal migration in adult mammalian brain. Proc Natl Acad Sci U S A 1996; 93: 14895-14900.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 14895-14900
    • Doetsch, F.1    Alvarez-Buylla, A.2
  • 71
    • 0030979469 scopus 로고    scopus 로고
    • Garcia Verdugo JM, Alvarez Buylla A. Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain 1
    • Doetsch F, Garcia Verdugo JM, Alvarez Buylla A. Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain 1. J Neurosci 1997; 17: 5046.
    • (1997) J Neurosci , vol.17 , pp. 5046
    • Doetsch, F.1
  • 72
  • 73
    • 0033040497 scopus 로고    scopus 로고
    • Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
    • Doetsch F, Caille I, Lim DA, Garcia-Verdugo JM, Alvarez-Buylla A. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell 1999; 97: 703-716.
    • (1999) Cell , vol.97 , pp. 703-716
    • Doetsch, F.1    Caille, I.2    Lim, D.A.3    Garcia-Verdugo, J.M.4    Alvarez-Buylla, A.5
  • 75
    • 0242317367 scopus 로고    scopus 로고
    • Glia as neural progenitor cells
    • Goldman S. Glia as neural progenitor cells. Trends in Neurosci 2003; 26: 590-596.
    • (2003) Trends in Neurosci , vol.26 , pp. 590-596
    • Goldman, S.1
  • 76
  • 77
    • 0027302887 scopus 로고
    • Differentiation of newly born neurons and glia in the dentate gyrus of the adult rat
    • Cameron HA, Woolley CS, McEwen BS, Gould E. Differentiation of newly born neurons and glia in the dentate gyrus of the adult rat. Neuroscience 1993; 56: 337-344.
    • (1993) Neuroscience , vol.56 , pp. 337-344
    • Cameron, H.A.1    Woolley, C.S.2    McEwen, B.S.3    Gould, E.4
  • 78
    • 70249105332 scopus 로고    scopus 로고
    • Adult neurogenesis and the olfactory system
    • Whitman MC, Greer CA. Adult neurogenesis and the olfactory system. Prog Neurobiol 2009; 89: 162-175.
    • (2009) Prog Neurobiol , vol.89 , pp. 162-175
    • Whitman, M.C.1    Greer, C.A.2
  • 79
    • 15544370150 scopus 로고    scopus 로고
    • Adult neurogenesis: from precursors to network and physiology
    • Abrous DN, Koehl M, Le Moal M. Adult neurogenesis: from precursors to network and physiology. Physiol Rev 2005; 85: 523-569.
    • (2005) Physiol Rev , vol.85 , pp. 523-569
    • Abrous, D.N.1    Koehl, M.2    Le Moal, M.3
  • 80
    • 0035833068 scopus 로고    scopus 로고
    • Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus
    • Cameron HA, McKay RD. Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus. J Comp Neurol 2001; 435: 406-417.
    • (2001) J Comp Neurol , vol.435 , pp. 406-417
    • Cameron, H.A.1    McKay, R.D.2
  • 82
    • 0030937293 scopus 로고    scopus 로고
    • More hippocampal neurons in adult mice living in an enriched environment
    • Kempermann G, Kuhn HG, Gage FH. More hippocampal neurons in adult mice living in an enriched environment. Nature 1997; 386: 493-495.
    • (1997) Nature , vol.386 , pp. 493-495
    • Kempermann, G.1    Kuhn, H.G.2    Gage, F.H.3
  • 84
    • 0030809453 scopus 로고    scopus 로고
    • Epidermal growth factor and fibroblast growth factor-2 have different effects on neural progenitors in the adult rat brain
    • Kuhn HG, Winkler J, Kempermann G, Thal LJ, Gage FH. Epidermal growth factor and fibroblast growth factor-2 have different effects on neural progenitors in the adult rat brain. J Neurosci 1997; 17: 5820-5829.
    • (1997) J Neurosci , vol.17 , pp. 5820-5829
    • Kuhn, H.G.1    Winkler, J.2    Kempermann, G.3    Thal, L.J.4    Gage, F.H.5
  • 85
    • 0026526516 scopus 로고
    • A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes
    • Reynolds BA, Tetzlaff W, Weiss S. A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes. J Neurosci 1992; 12: 4565-4574.
    • (1992) J Neurosci , vol.12 , pp. 4565-4574
    • Reynolds, B.A.1    Tetzlaff, W.2    Weiss, S.3
  • 86
    • 0028814611 scopus 로고
    • Proliferative zones of postnatal rat brain express epidermal growth factor receptor mRNA
    • Seroogy KB, Gall CM, Lee DC, Kornblum HI. Proliferative zones of postnatal rat brain express epidermal growth factor receptor mRNA. Brain Res 1995; 670: 157-164.
    • (1995) Brain Res , vol.670 , pp. 157-164
    • Seroogy, K.B.1    Gall, C.M.2    Lee, D.C.3    Kornblum, H.I.4
  • 87
    • 0344848564 scopus 로고    scopus 로고
    • Epidermal and fibroblast growth factors behave as mitogenic regulators for a single multipotent stem cell-like population from the subventricular region of the adult mouse forebrain
    • Gritti A, Frolichsthal-Schoeller P, Galli R, et al. Epidermal and fibroblast growth factors behave as mitogenic regulators for a single multipotent stem cell-like population from the subventricular region of the adult mouse forebrain. J Neurosci 1999; 19: 3287-3297.
    • (1999) J Neurosci , vol.19 , pp. 3287-3297
    • Gritti, A.1    Frolichsthal-Schoeller, P.2    Galli, R.3
  • 88
    • 0030938231 scopus 로고    scopus 로고
    • Prenatal ontogeny of the epidermal growth factor receptor and its ligand, transforming growth factor alpha, in the rat brain
    • Kornblum HI, Hussain RJ, Bronstein JM, Gall CM, Lee DC, Seroogy KB. Prenatal ontogeny of the epidermal growth factor receptor and its ligand, transforming growth factor alpha, in the rat brain. J Comp Neurol 1997; 380: 243-261.
    • (1997) J Comp Neurol , vol.380 , pp. 243-261
    • Kornblum, H.I.1    Hussain, R.J.2    Bronstein, J.M.3    Gall, C.M.4    Lee, D.C.5    Seroogy, K.B.6
  • 89
    • 0030826603 scopus 로고    scopus 로고
    • Transforming growth factor-alpha null and senescent mice show decreased neural progenitor cell proliferation in the forebrain subependyma
    • Tropepe V, Craig CG, Morshead CM, van der Kooy D. Transforming growth factor-alpha null and senescent mice show decreased neural progenitor cell proliferation in the forebrain subependyma. J Neurosci 1997; 17: 7850-7859.
    • (1997) J Neurosci , vol.17 , pp. 7850-7859
    • Tropepe, V.1    Craig, C.G.2    Morshead, C.M.3    van der Kooy, D.4
  • 90
    • 17444371643 scopus 로고    scopus 로고
    • Fibroblast growth factor 2 is required for maintaining the neural stem cell pool in the mouse brain subventricular zone
    • Zheng W, Nowakowski RS, Vaccarino FM. Fibroblast growth factor 2 is required for maintaining the neural stem cell pool in the mouse brain subventricular zone. Dev Neurosci 2004; 26: 181-196.
    • (2004) Dev Neurosci , vol.26 , pp. 181-196
    • Zheng, W.1    Nowakowski, R.S.2    Vaccarino, F.M.3
  • 91
    • 0141447477 scopus 로고    scopus 로고
    • Neurogenesis and aging: FGF-2 and HB-EGF restore neurogenesis in hippocampus and subventricular zone of aged mice
    • Jin K, Sun Y, Xie L, et al. Neurogenesis and aging: FGF-2 and HB-EGF restore neurogenesis in hippocampus and subventricular zone of aged mice. Aging Cell 2003; 2: 175-183.
    • (2003) Aging Cell , vol.2 , pp. 175-183
    • Jin, K.1    Sun, Y.2    Xie, L.3
  • 92
    • 0037137686 scopus 로고    scopus 로고
    • EGF converts transit-amplifying neurogenic precursors in the adult brain into multipotent stem cells
    • Doetsch F, Petreanu L, Caille I, Garcia-Verdugo JM, Alvarez-Buylla A. EGF converts transit-amplifying neurogenic precursors in the adult brain into multipotent stem cells. Neuron 2002; 36: 1021-1034.
    • (2002) Neuron , vol.36 , pp. 1021-1034
    • Doetsch, F.1    Petreanu, L.2    Caille, I.3    Garcia-Verdugo, J.M.4    Alvarez-Buylla, A.5
  • 93
    • 0029930911 scopus 로고    scopus 로고
    • In vivo growth factor expansion of endogenous subependymal neural precursor cell populations in the adult mouse brain
    • Craig CG, Tropepe V, Morshead CM, Reynolds BA, Weiss S, van der Kooy D. In vivo growth factor expansion of endogenous subependymal neural precursor cell populations in the adult mouse brain. J Neurosci 1996; 16: 2649-2658.
    • (1996) J Neurosci , vol.16 , pp. 2649-2658
    • Craig, C.G.1    Tropepe, V.2    Morshead, C.M.3    Reynolds, B.A.4    Weiss, S.5    van der Kooy, D.6
  • 94
    • 0030791066 scopus 로고    scopus 로고
    • In vivo neurogenesis is inhibited by neutralizing antibodies to basic fibroblast growth factor
    • Tao Y, Black IB, DiCicco-Bloom E. In vivo neurogenesis is inhibited by neutralizing antibodies to basic fibroblast growth factor. J Neurobiol 1997; 33: 289-296.
    • (1997) J Neurobiol , vol.33 , pp. 289-296
    • Tao, Y.1    Black, I.B.2    Dicicco-Bloom, E.3
  • 95
    • 0030472603 scopus 로고    scopus 로고
    • Neurogenesis in neonatal rat brain is regulated by peripheral injection of basic fibroblast growth factor (bFGF)
    • Tao Y, Black IB, DiCicco-Bloom E. Neurogenesis in neonatal rat brain is regulated by peripheral injection of basic fibroblast growth factor (bFGF). J Comp Neurol 1996; 376: 653-663.
    • (1996) J Comp Neurol , vol.376 , pp. 653-663
    • Tao, Y.1    Black, I.B.2    Dicicco-Bloom, E.3
  • 96
    • 29144517660 scopus 로고    scopus 로고
    • FGF2 promotes neurogenesis and neuroprotection in a transgenic mouse model of Huntington's disease
    • Jin K, LaFevre-Bernt M, Sun Y, et al. FGF2 promotes neurogenesis and neuroprotection in a transgenic mouse model of Huntington's disease. Proc Natl Acad Sci U S A 2005; 102: 18189-18194.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 18189-18194
    • Jin, K.1    Lafevre-Bernt, M.2    Sun, Y.3
  • 97
    • 33749841276 scopus 로고    scopus 로고
    • A progressive and cell non-autonomous increase in striatal neural stem cells in the Huntington's disease R6/2 mouse
    • Batista CM, Kippin TE, Willaime-Morawek S, Shimabukuro MK, Akamatsu W, van der Kooy D. A progressive and cell non-autonomous increase in striatal neural stem cells in the Huntington's disease R6/2 mouse. J Neurosci 2006; 26: 10452-10460.
    • (2006) J Neurosci , vol.26 , pp. 10452-10460
    • Batista, C.M.1    Kippin, T.E.2    Willaime-Morawek, S.3    Shimabukuro, M.K.4    Akamatsu, W.5    van der Kooy, D.6
  • 98
    • 34948855498 scopus 로고    scopus 로고
    • Induction of neostriatal neurogenesis slows disease progression in a transgenic murine model of Huntington disease
    • Cho SR, Benraiss A, Chmielnicki E, Samdani A, Economides A, Goldman SA. Induction of neostriatal neurogenesis slows disease progression in a transgenic murine model of Huntington disease. J Clin Invest 2007; 117: 2889-2902.
    • (2007) J Clin Invest , vol.117 , pp. 2889-2902
    • Cho, S.R.1    Benraiss, A.2    Chmielnicki, E.3    Samdani, A.4    Economides, A.5    Goldman, S.A.6
  • 99
    • 0034081681 scopus 로고    scopus 로고
    • The pattern of neurodegeneration in Huntington's disease: a comparative study of cannabinoid, dopamine, adenosine and GABA(A) receptor alterations in the human basal ganglia in Huntington's disease
    • Glass M, Dragunow M, Faull RL. The pattern of neurodegeneration in Huntington's disease: a comparative study of cannabinoid, dopamine, adenosine and GABA(A) receptor alterations in the human basal ganglia in Huntington's disease. Neuroscience 2000; 97: 505-519.
    • (2000) Neuroscience , vol.97 , pp. 505-519
    • Glass, M.1    Dragunow, M.2    Faull, R.L.3
  • 100
    • 0034737299 scopus 로고    scopus 로고
    • Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease
    • Yamamoto A, Lucas JJ, Hen R. Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease. Cell 2000; 101: 57-66.
    • (2000) Cell , vol.101 , pp. 57-66
    • Yamamoto, A.1    Lucas, J.J.2    Hen, R.3
  • 101
    • 33846804094 scopus 로고    scopus 로고
    • BDNF production by olfactory ensheathing cells contributes to axonal regeneration of cultured adult CNS neurons
    • Pastrana E, Moreno-Flores MT, Avila J, Wandosell F, Minichiello L, Diaz-Nido J. BDNF production by olfactory ensheathing cells contributes to axonal regeneration of cultured adult CNS neurons. Neurochem Int 2007; 50: 491-498.
    • (2007) Neurochem Int , vol.50 , pp. 491-498
    • Pastrana, E.1    Moreno-Flores, M.T.2    Avila, J.3    Wandosell, F.4    Minichiello, L.5    Diaz-Nido, J.6
  • 102
    • 43449095011 scopus 로고    scopus 로고
    • Dynamic expression of TrkB receptor protein on proliferating and maturing cells in the adult mouse dentate gyrus
    • Donovan MH, Yamaguchi M, Eisch AJ. Dynamic expression of TrkB receptor protein on proliferating and maturing cells in the adult mouse dentate gyrus. Hippocampus 2008; 18: 435-439.
    • (2008) Hippocampus , vol.18 , pp. 435-439
    • Donovan, M.H.1    Yamaguchi, M.2    Eisch, A.J.3
  • 103
    • 0028040712 scopus 로고
    • Brain-derived neurotrophic factor promotes differentiation of striatal GABAergic neurons
    • Mizuno K, Carnahan J, Nawa H. Brain-derived neurotrophic factor promotes differentiation of striatal GABAergic neurons. Dev Biol 1994; 165: 243-256.
    • (1994) Dev Biol , vol.165 , pp. 243-256
    • Mizuno, K.1    Carnahan, J.2    Nawa, H.3
  • 104
    • 0033168977 scopus 로고    scopus 로고
    • Expression of the striatal DARPP-32/ARPP-21 phenotype in GABAergic neurons requires neurotrophins in vivo and in vitro
    • Ivkovic S, Ehrlich ME. Expression of the striatal DARPP-32/ARPP-21 phenotype in GABAergic neurons requires neurotrophins in vivo and in vitro. J Neurosci 1999; 19: 5409-5419.
    • (1999) J Neurosci , vol.19 , pp. 5409-5419
    • Ivkovic, S.1    Ehrlich, M.E.2
  • 105
    • 0031009853 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor regulates maturation of the DARPP-32 phenotype in striatal medium spiny neurons: studies in vivo and in vitro
    • Ivkovic S, Polonskaia O, Farinas I, Ehrlich ME. Brain-derived neurotrophic factor regulates maturation of the DARPP-32 phenotype in striatal medium spiny neurons: studies in vivo and in vitro. Neuroscience 1997; 79: 509-516.
    • (1997) Neuroscience , vol.79 , pp. 509-516
    • Ivkovic, S.1    Polonskaia, O.2    Farinas, I.3    Ehrlich, M.E.4
  • 106
    • 0028800803 scopus 로고
    • The neurotrophins BDNF, NT-3 and NT-4/5 promote survival and morphological and biochemical differentiation of striatal neurons in vitro
    • Ventimiglia R, Mather PE, Jones BE, Lindsay RM. The neurotrophins BDNF, NT-3 and NT-4/5 promote survival and morphological and biochemical differentiation of striatal neurons in vitro. Eur J Neurosci 1995; 7: 213-222.
    • (1995) Eur J Neurosci , vol.7 , pp. 213-222
    • Ventimiglia, R.1    Mather, P.E.2    Jones, B.E.3    Lindsay, R.M.4
  • 107
    • 0028850676 scopus 로고
    • Trophic and protective actions of brain-derived neurotrophic factor on striatal DARPP-32-containing neurons in vitro
    • Nakao N, Brundin P, Funa K, Lindvall O, Odin P. Trophic and protective actions of brain-derived neurotrophic factor on striatal DARPP-32-containing neurons in vitro. Brain Res Dev Brain Res 1995; 90: 92-101.
    • (1995) Brain Res Dev Brain Res , vol.90 , pp. 92-101
    • Nakao, N.1    Brundin, P.2    Funa, K.3    Lindvall, O.4    Odin, P.5
  • 108
    • 0025281397 scopus 로고
    • The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain
    • Klein R, Conway D, Parada LF, Barbacid M. The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain. Cell 1990; 61: 647-656.
    • (1990) Cell , vol.61 , pp. 647-656
    • Klein, R.1    Conway, D.2    Parada, L.F.3    Barbacid, M.4
  • 109
    • 0026025820 scopus 로고
    • TrkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors
    • Middlemas DS, Lindberg RA, Hunter T. TrkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors. Mol Cell Biol 1991; 11: 143-153.
    • (1991) Mol Cell Biol , vol.11 , pp. 143-153
    • Middlemas, D.S.1    Lindberg, R.A.2    Hunter, T.3
  • 111
    • 0035919701 scopus 로고    scopus 로고
    • Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease
    • Zuccato C, Ciammola A, Rigamonti D, et al. Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease. Science 2001; 293: 493-498.
    • (2001) Science , vol.293 , pp. 493-498
    • Zuccato, C.1    Ciammola, A.2    Rigamonti, D.3
  • 112
    • 1842334441 scopus 로고    scopus 로고
    • Anterograde transport of brain-derived neurotrophic factor and its role in the brain
    • Altar CA, Cai N, Bliven T, et al. Anterograde transport of brain-derived neurotrophic factor and its role in the brain. Nature 1997; 389: 856-860.
    • (1997) Nature , vol.389 , pp. 856-860
    • Altar, C.A.1    Cai, N.2    Bliven, T.3
  • 113
    • 49149112606 scopus 로고    scopus 로고
    • Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons
    • Colin E, Zala D, Liot G, et al. Huntingtin phosphorylation acts as a molecular switch for anterograde/retrograde transport in neurons. EMBO J 2008; 27: 2124-2134.
    • (2008) EMBO J , vol.27 , pp. 2124-2134
    • Colin, E.1    Zala, D.2    Liot, G.3
  • 114
    • 35548937443 scopus 로고    scopus 로고
    • Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration
    • Strand AD, Baquet ZC, Aragaki AK, et al. Expression profiling of Huntington's disease models suggests that brain-derived neurotrophic factor depletion plays a major role in striatal degeneration. J Neurosci 2007; 27: 11758-11768.
    • (2007) J Neurosci , vol.27 , pp. 11758-11768
    • Strand, A.D.1    Baquet, Z.C.2    Aragaki, A.K.3
  • 115
    • 77955301371 scopus 로고
    • Neuroprotective mechanisms of brain-derived neurotrophic factor against 3-nitropropionic acid toxicity: Therapeutic implications for Huntington's disease
    • Wu CL, Hwang CS, Chen SD, Yin JH, Yang DI. Neuroprotective mechanisms of brain-derived neurotrophic factor against 3-nitropropionic acid toxicity: therapeutic implications for Huntington's disease. Ann N Y Acad Sci 1201: 8-12.
    • (1201) Ann N Y Acad Sci , pp. 8-12
    • Wu, C.L.1    Hwang, C.S.2    Chen, S.D.3    Yin, J.H.4    Yang, D.I.5
  • 116
    • 2442702838 scopus 로고    scopus 로고
    • AAV-mediated gene delivery of BDNF or GDNF is neuroprotective in a model of Huntington disease
    • Kells AP, Fong DM, Dragunow M, During MJ, Young D, Connor B. AAV-mediated gene delivery of BDNF or GDNF is neuroprotective in a model of Huntington disease. Mol Ther 2004; 9: 682-688.
    • (2004) Mol Ther , vol.9 , pp. 682-688
    • Kells, A.P.1    Fong, D.M.2    Dragunow, M.3    During, M.J.4    Young, D.5    Connor, B.6
  • 117
    • 13244296828 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor prevents changes in Bcl-2 family members and caspase-3 activation induced by excitotoxicity in the striatum
    • Perez-Navarro E, Gavalda N, Gratacos E, Alberch J. Brain-derived neurotrophic factor prevents changes in Bcl-2 family members and caspase-3 activation induced by excitotoxicity in the striatum. J Neurochem 2005; 92: 678-691.
    • (2005) J Neurochem , vol.92 , pp. 678-691
    • Perez-Navarro, E.1    Gavalda, N.2    Gratacos, E.3    Alberch, J.4
  • 118
    • 0034811810 scopus 로고    scopus 로고
    • Neuroprotection of striatal neurons against kainate excitotoxicity by neurotrophins and GDNF family members
    • Gratacos E, Perez-Navarro E, Tolosa E, Arenas E, Alberch J. Neuroprotection of striatal neurons against kainate excitotoxicity by neurotrophins and GDNF family members. J Neurochem 2001; 78: 1287-1296.
    • (2001) J Neurochem , vol.78 , pp. 1287-1296
    • Gratacos, E.1    Perez-Navarro, E.2    Tolosa, E.3    Arenas, E.4    Alberch, J.5
  • 119
    • 0036676160 scopus 로고    scopus 로고
    • Riluzole enhances expression of brain-derived neurotrophic factor with consequent proliferation of granule precursor cells in the rat hippocampus
    • Katoh-Semba R, Asano T, Ueda H, et al. Riluzole enhances expression of brain-derived neurotrophic factor with consequent proliferation of granule precursor cells in the rat hippocampus. FASEB J 2002; 16: 1328-1330.
    • (2002) FASEB J , vol.16 , pp. 1328-1330
    • Katoh-Semba, R.1    Asano, T.2    Ueda, H.3
  • 120
    • 33646421164 scopus 로고    scopus 로고
    • Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase
    • Borrell-Pages M, Canals JM, Cordelieres FP, et al. Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase. J Clin Invest 2006; 116: 1410-1424.
    • (2006) J Clin Invest , vol.116 , pp. 1410-1424
    • Borrell-Pages, M.1    Canals, J.M.2    Cordelieres, F.P.3
  • 121
    • 47249166444 scopus 로고    scopus 로고
    • Memantine upregulates BDNF and prevents dopamine deficits in SIV-infected macaques: a novel pharmacological action of memantine
    • Meisner F, Scheller C, Kneitz S, et al. Memantine upregulates BDNF and prevents dopamine deficits in SIV-infected macaques: a novel pharmacological action of memantine. Neuropsychopharmacology 2008; 33: 2228-2236.
    • (2008) Neuropsychopharmacology , vol.33 , pp. 2228-2236
    • Meisner, F.1    Scheller, C.2    Kneitz, S.3
  • 122
    • 63849151219 scopus 로고    scopus 로고
    • Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice
    • Simmons DA, Rex CS, Palmer L, et al. Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice. Proc Natl Acad Sci U S A 2009; 106: 4906-4911.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 4906-4911
    • Simmons, D.A.1    Rex, C.S.2    Palmer, L.3
  • 123
    • 49549088134 scopus 로고    scopus 로고
    • CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 mice
    • Apostol BL, Simmons DA, Zuccato C, et al. CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 mice. Mol Cell Neurosci 2008; 39: 8-20.
    • (2008) Mol Cell Neurosci , vol.39 , pp. 8-20
    • Apostol, B.L.1    Simmons, D.A.2    Zuccato, C.3
  • 124
    • 49549109150 scopus 로고    scopus 로고
    • Blood level of brain-derived neurotrophic factor mRNA is progressively reduced in rodent models of Huntington's disease: restoration by the neuroprotective compound CEP-1347
    • Conforti P, Ramos C, Apostol BL, et al. Blood level of brain-derived neurotrophic factor mRNA is progressively reduced in rodent models of Huntington's disease: restoration by the neuroprotective compound CEP-1347. Mol Cell Neurosci 2008; 39: 1-7.
    • (2008) Mol Cell Neurosci , vol.39 , pp. 1-7
    • Conforti, P.1    Ramos, C.2    Apostol, B.L.3
  • 125
    • 0028963215 scopus 로고
    • Brain-derived neurotrophic factor promotes the survival of neurons arising from the adult rat forebrain subependymal zone
    • Kirschenbaum B, Goldman SA. Brain-derived neurotrophic factor promotes the survival of neurons arising from the adult rat forebrain subependymal zone. Proc Natl Acad Sci USA 1995; 92: 210-214.
    • (1995) Proc Natl Acad Sci , vol.92 , pp. 210-214
    • Kirschenbaum, B.1    Goldman, S.A.2
  • 126
    • 0031856527 scopus 로고    scopus 로고
    • Intraventricular administration of BDNF increases the number of newly generated neurons in the adult olfactory bulb
    • Zigova T, Pencea V, Wiegand SJ, Luskin MB. Intraventricular administration of BDNF increases the number of newly generated neurons in the adult olfactory bulb. Mol Cell Neurosci 1998; 11: 234-245.
    • (1998) Mol Cell Neurosci , vol.11 , pp. 234-245
    • Zigova, T.1    Pencea, V.2    Wiegand, S.J.3    Luskin, M.B.4
  • 127
    • 0035448951 scopus 로고    scopus 로고
    • Adenoviral brain-derived neurotrophic factor induces both neostriatal and olfactory neuronal recruitment from endogenous progenitor cells in the adult forebrain
    • Benraiss A, Chmielnicki E, Lerner K, Roh D, Goldman SA. Adenoviral brain-derived neurotrophic factor induces both neostriatal and olfactory neuronal recruitment from endogenous progenitor cells in the adult forebrain. J Neurosci 2001; 21: 6718-6731.
    • (2001) J Neurosci , vol.21 , pp. 6718-6731
    • Benraiss, A.1    Chmielnicki, E.2    Lerner, K.3    Roh, D.4    Goldman, S.A.5
  • 128
    • 55049096710 scopus 로고    scopus 로고
    • Noninvasive and quantitative monitoring of adult neuronal stem cell migration in mouse brain using bioluminescence imaging
    • Reumers V, Deroose CM, Krylyshkina O, et al. Noninvasive and quantitative monitoring of adult neuronal stem cell migration in mouse brain using bioluminescence imaging. Stem Cells 2008; 26: 2382-2390.
    • (2008) Stem Cells , vol.26 , pp. 2382-2390
    • Reumers, V.1    Deroose, C.M.2    Krylyshkina, O.3
  • 129
    • 0035449745 scopus 로고    scopus 로고
    • Infusion of brain-derived neurotrophic factor into the lateral ventricle of the adult rat leads to new neurons in the parenchyma of the striatum, septum, thalamus, and hypothalamus
    • Pencea V, Bingaman KD, Wiegand SJ, Luskin MB. Infusion of brain-derived neurotrophic factor into the lateral ventricle of the adult rat leads to new neurons in the parenchyma of the striatum, septum, thalamus, and hypothalamus. J Neurosci 2001; 21: 6706-6717.
    • (2001) J Neurosci , vol.21 , pp. 6706-6717
    • Pencea, V.1    Bingaman, K.D.2    Wiegand, S.J.3    Luskin, M.B.4
  • 130
    • 0033970281 scopus 로고    scopus 로고
    • Developmental changes in progenitor cell responsiveness to bone morphogenetic proteins differentially modulate progressive CNS lineage fate
    • Mehler MF, Mabie PC, Zhu G, Gokhan S, Kessler JA. Developmental changes in progenitor cell responsiveness to bone morphogenetic proteins differentially modulate progressive CNS lineage fate. Dev Neurosci 2000; 22: 74-85.
    • (2000) Dev Neurosci , vol.22 , pp. 74-85
    • Mehler, M.F.1    Mabie, P.C.2    Zhu, G.3    Gokhan, S.4    Kessler, J.A.5
  • 131
    • 0030273439 scopus 로고    scopus 로고
    • Bone morphogenetic proteins promote astroglial lineage commitment by mammalian subventricular zone progenitor cells
    • Gross RE, Mehler MF, Mabie PC, Zang Z, Santschi L, Kessler JA. Bone morphogenetic proteins promote astroglial lineage commitment by mammalian subventricular zone progenitor cells. Neuron 1996; 17: 595-606.
    • (1996) Neuron , vol.17 , pp. 595-606
    • Gross, R.E.1    Mehler, M.F.2    Mabie, P.C.3    Zang, Z.4    Santschi, L.5    Kessler, J.A.6
  • 133
    • 0029051869 scopus 로고
    • Identification of mammalian noggin and its expression in the adult nervous system
    • Valenzuela DM, Economides AN, Rojas E, et al. Identification of mammalian noggin and its expression in the adult nervous system. J Neurosci 1995; 15: 6077-6084.
    • (1995) J Neurosci , vol.15 , pp. 6077-6084
    • Valenzuela, D.M.1    Economides, A.N.2    Rojas, E.3
  • 134
    • 0026646326 scopus 로고
    • Expression cloning of noggin a new dorsalizing factor localized to the spemann organizer in xenopus embryos
    • Smith WC, Harland RM. Expression cloning of noggin a new dorsalizing factor localized to the spemann organizer in xenopus embryos. Cell 1992; 70: 829-840.
    • (1992) Cell , vol.70 , pp. 829-840
    • Smith, W.C.1    Harland, R.M.2
  • 135
    • 0033566915 scopus 로고    scopus 로고
    • Multiple roles of bone morphogenetic protein signaling in the regulation of cortical cell number and phenotype
    • Mabie PC, Mehler MF, Kessler JA. Multiple roles of bone morphogenetic protein signaling in the regulation of cortical cell number and phenotype. J Neurosci 1999; 19: 7077-7088.
    • (1999) J Neurosci , vol.19 , pp. 7077-7088
    • Mabie, P.C.1    Mehler, M.F.2    Kessler, J.A.3
  • 136
    • 0037333616 scopus 로고    scopus 로고
    • Transgenic overexpression of BMP4 increases astroglial and decreases oligodendroglial lineage commitment
    • Gomes WA, Mehler MF, Kessler JA. Transgenic overexpression of BMP4 increases astroglial and decreases oligodendroglial lineage commitment. Developmental Biology 2003; 255: 164-177.
    • (2003) Developmental Biology , vol.255 , pp. 164-177
    • Gomes, W.A.1    Mehler, M.F.2    Kessler, J.A.3
  • 137
    • 1542376943 scopus 로고    scopus 로고
    • Adenovirally expressed noggin and brain-derived neurotrophic factor cooperate to induce new medium spiny neurons from resident progenitor cells in the adult striatal ventricular zone
    • Chmielnicki E, Benraiss A, Economides AN, Goldman SA. Adenovirally expressed noggin and brain-derived neurotrophic factor cooperate to induce new medium spiny neurons from resident progenitor cells in the adult striatal ventricular zone. Journal of Neuroscience 2004; 24: 2133-2142.
    • (2004) Journal of Neuroscience , vol.24 , pp. 2133-2142
    • Chmielnicki, E.1    Benraiss, A.2    Economides, A.N.3    Goldman, S.A.4
  • 138
    • 55049134362 scopus 로고    scopus 로고
    • Fate mapping and lineage analyses demonstrate the production of a large number of striatal neuroblasts after transforming growth factor alpha and noggin striatal infusions into the dopamine-depleted striatum
    • de Chevigny A, Cooper O, Vinuela A, et al. Fate mapping and lineage analyses demonstrate the production of a large number of striatal neuroblasts after transforming growth factor alpha and noggin striatal infusions into the dopamine-depleted striatum. Stem Cells 2008; 26: 2349-2360.
    • (2008) Stem Cells , vol.26 , pp. 2349-2360
    • de Chevigny, A.1    Cooper, O.2    Vinuela, A.3
  • 140
    • 16044373842 scopus 로고    scopus 로고
    • Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice
    • Mangiarini L, Sathasivam K, Seller M, et al. Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell 1996; 87: 493-506.
    • (1996) Cell , vol.87 , pp. 493-506
    • Mangiarini, L.1    Sathasivam, K.2    Seller, M.3
  • 141
    • 26844498655 scopus 로고    scopus 로고
    • The use of the R6 transgenic mouse models of Huntington's disease in attempts to develop novel therapeutic strategies
    • Li JY, Popovic N, Brundin P. The use of the R6 transgenic mouse models of Huntington's disease in attempts to develop novel therapeutic strategies. NeuroRx 2005; 2: 447-464.
    • (2005) NeuroRx , vol.2 , pp. 447-464
    • Li, J.Y.1    Popovic, N.2    Brundin, P.3
  • 142
    • 33645715283 scopus 로고    scopus 로고
    • Chemical characterization of newly generated neurons in the striatum of adult primates
    • Bedard A, Gravel C, Parent A. Chemical characterization of newly generated neurons in the striatum of adult primates. Exp Brain Res 2006; 170: 501-512.
    • (2006) Exp Brain Res , vol.170 , pp. 501-512
    • Bedard, A.1    Gravel, C.2    Parent, A.3
  • 143
    • 0027517744 scopus 로고
    • In vivo adenoviral vector-mediated gene transfer into balloon-injured rat carotid arteries
    • Lee SW, Trapnell BC, Rade JJ, Virmani R, Dichek DA. In vivo adenoviral vector-mediated gene transfer into balloon-injured rat carotid arteries. Circ Res 1993; 73: 797-807.
    • (1993) Circ Res , vol.73 , pp. 797-807
    • Lee, S.W.1    Trapnell, B.C.2    Rade, J.J.3    Virmani, R.4    Dichek, D.A.5
  • 144
    • 0028234357 scopus 로고
    • In vivo correction of low density lipoprotein receptor deficiency in the Watanabe heritable hyperlipidemic rabbit with recombinant adenoviruses
    • Kozarsky KF, McKinley DR, Austin LL, Raper SE, Stratford-Perricaudet LD, Wilson JM. In vivo correction of low density lipoprotein receptor deficiency in the Watanabe heritable hyperlipidemic rabbit with recombinant adenoviruses. J Biol Chem 1994; 269: 13695-13702.
    • (1994) J Biol Chem , vol.269 , pp. 13695-13702
    • Kozarsky, K.F.1    McKinley, D.R.2    Austin, L.L.3    Raper, S.E.4    Stratford-Perricaudet, L.D.5    Wilson, J.M.6
  • 145
    • 0028934815 scopus 로고
    • Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: tolerization of factor IX and vector antigens allows for long-term expression
    • Dai Y, Schwarz EM, Gu D, Zhang WW, Sarvetnick N, Verma IM. Cellular and humoral immune responses to adenoviral vectors containing factor IX gene: tolerization of factor IX and vector antigens allows for long-term expression. Proc Natl Acad Sci U S A 1995; 92: 1401-1405.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 1401-1405
    • Dai, Y.1    Schwarz, E.M.2    Gu, D.3    Zhang, W.W.4    Sarvetnick, N.5    Verma, I.M.6
  • 146
    • 29644443722 scopus 로고    scopus 로고
    • Intracerebral adeno-associated virus-mediated gene transfer in rapidly progressive forms of metachromatic leukodystrophy
    • Sevin C, Benraiss A, van Dam D, et al. Intracerebral adeno-associated virus-mediated gene transfer in rapidly progressive forms of metachromatic leukodystrophy. Hum Mol Genet 2006; 15: 53-64.
    • (2006) Hum Mol Genet , vol.15 , pp. 53-64
    • Sevin, C.1    Benraiss, A.2    van Dam, D.3
  • 147
    • 0034212887 scopus 로고    scopus 로고
    • Adeno-associated virus vectors: activity and applications in the CNS
    • Peel AL, Klein RL. Adeno-associated virus vectors: activity and applications in the CNS. J Neurosci Methods 2000; 98: 95-104.
    • (2000) J Neurosci Methods , vol.98 , pp. 95-104
    • Peel, A.L.1    Klein, R.L.2
  • 148
    • 33748083041 scopus 로고    scopus 로고
    • Long-term clinical improvement in MPTP-lesioned primates after gene therapy with AAV-hAADC
    • Bankiewicz KS, Forsayeth J, Eberling JL, et al. Long-term clinical improvement in MPTP-lesioned primates after gene therapy with AAV-hAADC. Mol Ther 2006; 14: 564-570.
    • (2006) Mol Ther , vol.14 , pp. 564-570
    • Bankiewicz, K.S.1    Forsayeth, J.2    Eberling, J.L.3
  • 149
    • 52949147794 scopus 로고    scopus 로고
    • Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain
    • Imayoshi I, Sakamoto M, Ohtsuka T, et al. Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain. Nat Neurosci 2008; 11: 1153-1161.
    • (2008) Nat Neurosci , vol.11 , pp. 1153-1161
    • Imayoshi, I.1    Sakamoto, M.2    Ohtsuka, T.3


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