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Volumn 72, Issue 2-3 SPEC. ISS., 2007, Pages 132-147

Cell transplantation for Huntington's disease. Should we continue?

Author keywords

Animal models; Brain repair; Clinical trials; Huntington's disease; Neurotransplantation

Indexed keywords

CELL TRANSPLANTATION; CLINICAL TRIAL; FEASIBILITY STUDY; HEALTH SURVEY; HEREDITY; HUMAN; HUNTINGTON CHOREA; METHODOLOGY; NEUROPATHOLOGY; NONHUMAN; PATIENT ASSESSMENT; PATIENT SELECTION; PRIORITY JOURNAL; REVIEW; SAFETY;

EID: 33847673272     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2006.10.019     Document Type: Review
Times cited : (34)

References (122)
  • 1
    • 0036902881 scopus 로고    scopus 로고
    • Fetal striatal transplantation in Huntington's disease: time for a pause-the need to look at the rationale for fetal striatal transplantation
    • Albin R.L. Fetal striatal transplantation in Huntington's disease: time for a pause-the need to look at the rationale for fetal striatal transplantation. J. Neurol. Neurosurg. Psychiatr. 73 (2002) 612
    • (2002) J. Neurol. Neurosurg. Psychiatr. , vol.73 , pp. 612
    • Albin, R.L.1
  • 5
    • 0038701684 scopus 로고    scopus 로고
    • Huntingtin aggregation and toxicity in Huntington's disease
    • Bates G. Huntingtin aggregation and toxicity in Huntington's disease. Lancet 361 (2003) 1642-1644
    • (2003) Lancet , vol.361 , pp. 1642-1644
    • Bates, G.1
  • 6
    • 2342598416 scopus 로고    scopus 로고
    • Experimental therapeutics in transgenic mouse models of Huntington's disease
    • Beal M.F., and Ferrante R.J. Experimental therapeutics in transgenic mouse models of Huntington's disease. Nat. Rev. Neurosci. 5 (2004) 373-384
    • (2004) Nat. Rev. Neurosci. , vol.5 , pp. 373-384
    • Beal, M.F.1    Ferrante, R.J.2
  • 8
    • 0034032642 scopus 로고    scopus 로고
    • Cell replacement therapies for central nervous system disorders
    • Björklund A., and Lindvall O. Cell replacement therapies for central nervous system disorders. Nat. Neurosci. 3 (2000) 537-544
    • (2000) Nat. Neurosci. , vol.3 , pp. 537-544
    • Björklund, A.1    Lindvall, O.2
  • 9
    • 0028104614 scopus 로고
    • Ethical guidelines for the use of human embryonic or fetal tissue for experimental and clinical neurotransplantation and research
    • Boer G.J. Ethical guidelines for the use of human embryonic or fetal tissue for experimental and clinical neurotransplantation and research. J. Neurol. 242 (1994) 1-13
    • (1994) J. Neurol. , vol.242 , pp. 1-13
    • Boer, G.J.1
  • 10
    • 0037201104 scopus 로고    scopus 로고
    • Clinical neurotransplantation: core assessment protocol rather than sham surgery as control
    • Boer G.J., and Widner H. Clinical neurotransplantation: core assessment protocol rather than sham surgery as control. Brain Res. Bull. 58 (2002) 547-553
    • (2002) Brain Res. Bull. , vol.58 , pp. 547-553
    • Boer, G.J.1    Widner, H.2
  • 11
    • 0028856643 scopus 로고
    • Asymmetrical behavior in rats following striatal lesions and fetal transplants: the elevated body swing test
    • Borlongan C.V., Cahill D.W., and Sanberg P.R. Asymmetrical behavior in rats following striatal lesions and fetal transplants: the elevated body swing test. Rest. Neurol. Neurosci. 9 (1995) 15-19
    • (1995) Rest. Neurol. Neurosci. , vol.9 , pp. 15-19
    • Borlongan, C.V.1    Cahill, D.W.2    Sanberg, P.R.3
  • 14
    • 0030028145 scopus 로고    scopus 로고
    • Paucity of P-zones in striatal grafts prohibit commencement of clinical trials in Huntington's disease
    • Brundin P., Fricker R.A., and Nakao N. Paucity of P-zones in striatal grafts prohibit commencement of clinical trials in Huntington's disease. Neuroscience 71 (1996) 895-897
    • (1996) Neuroscience , vol.71 , pp. 895-897
    • Brundin, P.1    Fricker, R.A.2    Nakao, N.3
  • 15
    • 0141987860 scopus 로고    scopus 로고
    • The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg
    • Ciechanover A., and Brundin P. The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg. Neuron 40 (2003) 427-446
    • (2003) Neuron , vol.40 , pp. 427-446
    • Ciechanover, A.1    Brundin, P.2
  • 16
    • 0017167057 scopus 로고
    • Lesions of striatal neurones with kainic acid provides a model for Huntington's chorea
    • Coyle J.T., and Schwarcz R. Lesions of striatal neurones with kainic acid provides a model for Huntington's chorea. Nature 263 (1976) 244-246
    • (1976) Nature , vol.263 , pp. 244-246
    • Coyle, J.T.1    Schwarcz, R.2
  • 18
    • 0028585837 scopus 로고
    • The lateral ganglionic eminence is the origin of cells committed to striatal phenotypes: neural transplantation and developmental evidence
    • Deacon T.W., Pakzaban P., and Isacson O. The lateral ganglionic eminence is the origin of cells committed to striatal phenotypes: neural transplantation and developmental evidence. Brain Res. 668 (1994) 211-219
    • (1994) Brain Res. , vol.668 , pp. 211-219
    • Deacon, T.W.1    Pakzaban, P.2    Isacson, O.3
  • 19
    • 0033428823 scopus 로고    scopus 로고
    • Core assessment program for surgical interventional therapies in Parkinson's disease (CAPSIT-PD)
    • Defer G.L., Widner H., Marié R.M., Rémy P., and Levivier M. Core assessment program for surgical interventional therapies in Parkinson's disease (CAPSIT-PD). Mov. Disord. 14 (1999) 572-584
    • (1999) Mov. Disord. , vol.14 , pp. 572-584
    • Defer, G.L.1    Widner, H.2    Marié, R.M.3    Rémy, P.4    Levivier, M.5
  • 20
    • 0028872929 scopus 로고
    • Functional repair of striatal systems by neural transplants: evidence for circuit reconstruction
    • Dunnett S.B. Functional repair of striatal systems by neural transplants: evidence for circuit reconstruction. Behav. Brain Res. 66 (1995) 133-142
    • (1995) Behav. Brain Res. , vol.66 , pp. 133-142
    • Dunnett, S.B.1
  • 23
    • 26244445193 scopus 로고    scopus 로고
    • Frontal-striatal disconnection disrupts cognitive performance of the frontal-type in the rat
    • Dunnett S.B., Meldrum A., and Muir J.L. Frontal-striatal disconnection disrupts cognitive performance of the frontal-type in the rat. Neuroscience 155 (2005) 1055-1065
    • (2005) Neuroscience , vol.155 , pp. 1055-1065
    • Dunnett, S.B.1    Meldrum, A.2    Muir, J.L.3
  • 24
  • 25
    • 15444378095 scopus 로고    scopus 로고
    • Cell therapy in Huntington's disease
    • Dunnett S.B., and Rosser A.E. Cell therapy in Huntington's disease. NeuroRx 1 (2004) 394-405
    • (2004) NeuroRx , vol.1 , pp. 394-405
    • Dunnett, S.B.1    Rosser, A.E.2
  • 26
    • 33745261233 scopus 로고    scopus 로고
    • Striatal grafts alleviate bilateral striatal lesion deficits in operant delayed alternation in the rat
    • Dunnett S.B., White A., Heath J., Torres E.M., and Gates R.A. Striatal grafts alleviate bilateral striatal lesion deficits in operant delayed alternation in the rat. Exp. Neurol. 199 (2006) 478-489
    • (2006) Exp. Neurol. , vol.199 , pp. 478-489
    • Dunnett, S.B.1    White, A.2    Heath, J.3    Torres, E.M.4    Gates, R.A.5
  • 27
    • 33847619878 scopus 로고    scopus 로고
    • European Parliament and Council, Directive 2004/23/EC of 31 March 2004, on setting standards of quality and safety for the donation, procurement, testing, processing, preservation, storage and distribution of human tissues and cells. Off. J. Eur. Union L102 (2004) 48-58.
  • 28
    • 33746708104 scopus 로고    scopus 로고
    • Neural transplantation in Huntington's disease: NEST-UK donor tissue microbiological screening programme and review of the literature
    • Farrington M., Wreghitt T.G., Lever A.M., Dunnett S.B., Rosser A.E., and Barker R.A. Neural transplantation in Huntington's disease: NEST-UK donor tissue microbiological screening programme and review of the literature. Cell Transplant. 15 (2006) 279-289
    • (2006) Cell Transplant. , vol.15 , pp. 279-289
    • Farrington, M.1    Wreghitt, T.G.2    Lever, A.M.3    Dunnett, S.B.4    Rosser, A.E.5    Barker, R.A.6
  • 31
    • 0029895301 scopus 로고    scopus 로고
    • Survival and proliferation of non-neural tissues, with obstruction of cerebral ventricles, in a Parkinsonian patient treated with fetal allografts
    • Folkerth R.D., and Durso R. Survival and proliferation of non-neural tissues, with obstruction of cerebral ventricles, in a Parkinsonian patient treated with fetal allografts. Neurology 46 (1996) 1219-1225
    • (1996) Neurology , vol.46 , pp. 1219-1225
    • Folkerth, R.D.1    Durso, R.2
  • 34
    • 0030754874 scopus 로고    scopus 로고
    • The effects of donor stage on the survival and function of embryonic striatal grafts. II: Correlation between positron emission tomography and reaching behaviour
    • Fricker R.A., Torres E.M., Hume S.P., Myers R., Opacka-Juffry J., Ashworth S., and Dunnett S.B. The effects of donor stage on the survival and function of embryonic striatal grafts. II: Correlation between positron emission tomography and reaching behaviour. Neuroscience 79 (1997) 711-722
    • (1997) Neuroscience , vol.79 , pp. 711-722
    • Fricker, R.A.1    Torres, E.M.2    Hume, S.P.3    Myers, R.4    Opacka-Juffry, J.5    Ashworth, S.6    Dunnett, S.B.7
  • 38
    • 0029993991 scopus 로고    scopus 로고
    • Phenotypic development of the human embryonic striatal primordium: a study of cultured and grafted neurons from the lateral and medial ganglionic eminence
    • Grasbon-Frodl E.M., Nakao N., Lindvall O., and Brundin P. Phenotypic development of the human embryonic striatal primordium: a study of cultured and grafted neurons from the lateral and medial ganglionic eminence. Neuroscience 73 (1996) 171-183
    • (1996) Neuroscience , vol.73 , pp. 171-183
    • Grasbon-Frodl, E.M.1    Nakao, N.2    Lindvall, O.3    Brundin, P.4
  • 39
    • 0030932167 scopus 로고    scopus 로고
    • Developmental features of human striatal tissue transplanted in a rat model of Huntington's disease
    • Grasbon-Frodl E.M., Nakao N., Lindvall O., and Brundin P. Developmental features of human striatal tissue transplanted in a rat model of Huntington's disease. Neurobiol. Dis. 3 (1997) 299-311
    • (1997) Neurobiol. Dis. , vol.3 , pp. 299-311
    • Grasbon-Frodl, E.M.1    Nakao, N.2    Lindvall, O.3    Brundin, P.4
  • 40
    • 0024439946 scopus 로고
    • Intrastriatal grafts derived from fetal striatal primordia. 1: Phenotypy and modular organization
    • Graybiel A.M., Liu F.C., and Dunnett S.B. Intrastriatal grafts derived from fetal striatal primordia. 1: Phenotypy and modular organization. J. Neurosci. 9 (1989) 3250-3271
    • (1989) J. Neurosci. , vol.9 , pp. 3250-3271
    • Graybiel, A.M.1    Liu, F.C.2    Dunnett, S.B.3
  • 41
    • 0037066135 scopus 로고    scopus 로고
    • We need something better and we need it now-fetal striatal transplantation in Huntington's disease?
    • Greenamyre J.T., and Shoulson I. We need something better and we need it now-fetal striatal transplantation in Huntington's disease?. Neurology 58 (2002) 675-676
    • (2002) Neurology , vol.58 , pp. 675-676
    • Greenamyre, J.T.1    Shoulson, I.2
  • 45
    • 0037066096 scopus 로고    scopus 로고
    • Bilateral human fetal striatal transplantation in Huntington's disease
    • Hauser R.A., Sandberg P.R., Freeman T.B., and Stoessl A.J. Bilateral human fetal striatal transplantation in Huntington's disease. Neurology 58 (2002) 1704
    • (2002) Neurology , vol.58 , pp. 1704
    • Hauser, R.A.1    Sandberg, P.R.2    Freeman, T.B.3    Stoessl, A.J.4
  • 46
    • 0037376680 scopus 로고    scopus 로고
    • Apoptosis in Huntington's disease
    • Hickey M.A., and Chesselet M.F. Apoptosis in Huntington's disease. Prog. Neurol. 27 (2003) 255-265
    • (2003) Prog. Neurol. , vol.27 , pp. 255-265
    • Hickey, M.A.1    Chesselet, M.F.2
  • 47
    • 0031900412 scopus 로고    scopus 로고
    • Quantitative proton-decoupled 31P MRS and 1H MRS in the evaluation of Huntington's and Parkinson's diseases
    • Hoang T.Q., Bluml S., Dubowitz D.J., Moats R., Kopyov O., Jacques D., and Ross B.D. Quantitative proton-decoupled 31P MRS and 1H MRS in the evaluation of Huntington's and Parkinson's diseases. Neurology 50 (1998) 1033-1040
    • (1998) Neurology , vol.50 , pp. 1033-1040
    • Hoang, T.Q.1    Bluml, S.2    Dubowitz, D.J.3    Moats, R.4    Kopyov, O.5    Jacques, D.6    Ross, B.D.7
  • 48
    • 0027480960 scopus 로고
    • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
    • Huntington's Disease Collaborative Research Group
    • Huntington's Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 72 (1993) 971-983
    • (1993) Cell , vol.72 , pp. 971-983
  • 49
    • 0242407061 scopus 로고    scopus 로고
    • Long-term hibernation of human fetal striatal tissue does not adversely affect its differentiation in vitro or graft survival: implications for clinical trials in Huntington's disease
    • Hurelbrink C.B., Tyers P., Armstrong R.J.E., Dunnett S.B., Barker R.A., and Rosser A.E. Long-term hibernation of human fetal striatal tissue does not adversely affect its differentiation in vitro or graft survival: implications for clinical trials in Huntington's disease. Cell Transplant. 12 (2003) 687-695
    • (2003) Cell Transplant. , vol.12 , pp. 687-695
    • Hurelbrink, C.B.1    Tyers, P.2    Armstrong, R.J.E.3    Dunnett, S.B.4    Barker, R.A.5    Rosser, A.E.6
  • 50
    • 0021226160 scopus 로고
    • Functional neuronal replacement by grafted striatal neurons in the ibotenic acid lesioned rat striatum
    • Isacson O., Brundin P., Kelly P.A.T., Gage F.H., and Björklund A. Functional neuronal replacement by grafted striatal neurons in the ibotenic acid lesioned rat striatum. Nature 311 (1984) 458-460
    • (1984) Nature , vol.311 , pp. 458-460
    • Isacson, O.1    Brundin, P.2    Kelly, P.A.T.3    Gage, F.H.4    Björklund, A.5
  • 51
    • 33847625558 scopus 로고    scopus 로고
    • Neuronal cells for transplantation in Huntington's disease
    • Davis-Sanberg C., and Sanberg P.R. (Eds), Humana Press, Totowa
    • Kelly C.M., Rosser A.E., and Dunnett S.B. Neuronal cells for transplantation in Huntington's disease. In: Davis-Sanberg C., and Sanberg P.R. (Eds). Cell Therapy for Brain Repair (2006), Humana Press, Totowa 83-115
    • (2006) Cell Therapy for Brain Repair , pp. 83-115
    • Kelly, C.M.1    Rosser, A.E.2    Dunnett, S.B.3
  • 53
    • 0031777250 scopus 로고    scopus 로고
    • Functional integration of striatal allografts in a primate model of Huntington's disease
    • Kendall A.L., Rayment F.D., Torres E.M., Baker H.F., Ridley R.M., and Dunnett S.B. Functional integration of striatal allografts in a primate model of Huntington's disease. Nat. Med. 4 (1998) 727-729
    • (1998) Nat. Med. , vol.4 , pp. 727-729
    • Kendall, A.L.1    Rayment, F.D.2    Torres, E.M.3    Baker, H.F.4    Ridley, R.M.5    Dunnett, S.B.6
  • 54
    • 21944446706 scopus 로고    scopus 로고
    • Histological analysis of fetal dopamine cell suspension grafts in two patients with Parkinson's disease gives promising results
    • Kirik D., and Björklund A. Histological analysis of fetal dopamine cell suspension grafts in two patients with Parkinson's disease gives promising results. Brain 128 (2005) 1478-1479
    • (2005) Brain , vol.128 , pp. 1478-1479
    • Kirik, D.1    Björklund, A.2
  • 56
    • 0031887047 scopus 로고    scopus 로고
    • Safety of intrastriatal neurotransplantation for Huntington's disease patients
    • Kopyov O.V., Jacques S., Lieberman A., Duma C.M., and Eagle K.S. Safety of intrastriatal neurotransplantation for Huntington's disease patients. Exp. Neurol. 119 (1998) 97-108
    • (1998) Exp. Neurol. , vol.119 , pp. 97-108
    • Kopyov, O.V.1    Jacques, S.2    Lieberman, A.3    Duma, C.M.4    Eagle, K.S.5
  • 57
    • 0031106244 scopus 로고    scopus 로고
    • Dopaminergic transplants in patients with Parkinson's disease: neuroanatomical correlates of clinical recovery
    • Kordower J.H., Goetz C.G., Freeman T.B., and Olanow C.W. Dopaminergic transplants in patients with Parkinson's disease: neuroanatomical correlates of clinical recovery. Exp. Neurol. 144 (1997) 41-46
    • (1997) Exp. Neurol. , vol.144 , pp. 41-46
    • Kordower, J.H.1    Goetz, C.G.2    Freeman, T.B.3    Olanow, C.W.4
  • 58
    • 33847671486 scopus 로고    scopus 로고
    • Improvement in motor function after fetal transplantation in a patient with Huntington's disease
    • Kurth M.C., Kopyov O., and Jacques D.B. Improvement in motor function after fetal transplantation in a patient with Huntington's disease. Neurology 46 (1996) 22006
    • (1996) Neurology , vol.46 , pp. 22006
    • Kurth, M.C.1    Kopyov, O.2    Jacques, D.B.3
  • 59
    • 0026515731 scopus 로고
    • Core assessment program for intracerebral transplantation (CAPIT)
    • Langston J.W., Widner H., and Goetz C.G. Core assessment program for intracerebral transplantation (CAPIT). Mov. Disord. 7 (1992) 2-13
    • (1992) Mov. Disord. , vol.7 , pp. 2-13
    • Langston, J.W.1    Widner, H.2    Goetz, C.G.3
  • 60
    • 0027957150 scopus 로고
    • Vascularization and microvascular permeability in solid versus cell-suspension embryonic neural grafts
    • Leigh K., Elisevich K., and Rogers K.A. Vascularization and microvascular permeability in solid versus cell-suspension embryonic neural grafts. J. Neurosurg. 81 (1994) 272-283
    • (1994) J. Neurosurg. , vol.81 , pp. 272-283
    • Leigh, K.1    Elisevich, K.2    Rogers, K.A.3
  • 61
    • 0034589755 scopus 로고    scopus 로고
    • Clinical observations after neural transplantation in Parkinson's disease
    • Lindvall O., and Hagell P. Clinical observations after neural transplantation in Parkinson's disease. Prog. Brain Res. 127 (2000) 299-320
    • (2000) Prog. Brain Res. , vol.127 , pp. 299-320
    • Lindvall, O.1    Hagell, P.2
  • 65
    • 33846450521 scopus 로고    scopus 로고
    • Synaptic plasticity in striatal grafts
    • Bolam J.P., Ingham C.A., and Magill P.J. (Eds), Springer, New York
    • Mazzocchi-Jones D., Döbrössy M.D., and Dunnett S.B. Synaptic plasticity in striatal grafts. In: Bolam J.P., Ingham C.A., and Magill P.J. (Eds). The Basal Ganglia VIII (2005), Springer, New York 313-320
    • (2005) The Basal Ganglia VIII , pp. 313-320
    • Mazzocchi-Jones, D.1    Döbrössy, M.D.2    Dunnett, S.B.3
  • 66
    • 33847642918 scopus 로고    scopus 로고
    • Medical Research Council, Guidelines for Good Clinical Practice, Medical Research Council, London, 1998.
  • 68
    • 0029778165 scopus 로고    scopus 로고
    • The public health risk of animal organ and tissue transplantation into humans
    • Murphy F.A. The public health risk of animal organ and tissue transplantation into humans. Science 273 (1996) 746-747
    • (1996) Science , vol.273 , pp. 746-747
    • Murphy, F.A.1
  • 69
    • 0030045705 scopus 로고    scopus 로고
    • Ontogeny of human striatal DARPP-32 neurons in fetuses and following xenografting to the adult rat brain
    • Naimi S., Jény R., Hantraye P., Peschanski M., and Riche D. Ontogeny of human striatal DARPP-32 neurons in fetuses and following xenografting to the adult rat brain. Exp. Neurol. 137 (1996) 15-25
    • (1996) Exp. Neurol. , vol.137 , pp. 15-25
    • Naimi, S.1    Jény, R.2    Hantraye, P.3    Peschanski, M.4    Riche, D.5
  • 70
    • 0032890301 scopus 로고    scopus 로고
    • Embryonic striatal grafts restore neuronal activity of the globus pallidus in a rodent model of Huntington's disease
    • Nakao N., Ogura M., Nakai K., and Itakura T. Embryonic striatal grafts restore neuronal activity of the globus pallidus in a rodent model of Huntington's disease. Neuroscience 88 (1999) 469-477
    • (1999) Neuroscience , vol.88 , pp. 469-477
    • Nakao, N.1    Ogura, M.2    Nakai, K.3    Itakura, T.4
  • 71
    • 0028084486 scopus 로고
    • Improved graft survival and striatal reinnervation by microtransplantation of fetal nigral cell suspensions in the rat Parkinson model
    • Nikkhah G., Cunningham M.G., Jödicke A., Knappe U., and Björklund A. Improved graft survival and striatal reinnervation by microtransplantation of fetal nigral cell suspensions in the rat Parkinson model. Brain Res. 633 (1994) 133-143
    • (1994) Brain Res. , vol.633 , pp. 133-143
    • Nikkhah, G.1    Cunningham, M.G.2    Jödicke, A.3    Knappe, U.4    Björklund, A.5
  • 72
    • 0027204258 scopus 로고
    • Striatal grafts in the ischemic striatum improve pallidal GABA release and passive avoidance
    • Nishino H., Koide K., Aihara N., Kumazaki M., Sakurai T., and Nagai H. Striatal grafts in the ischemic striatum improve pallidal GABA release and passive avoidance. Brain Res. Bull. 32 (1993) 517-520
    • (1993) Brain Res. Bull. , vol.32 , pp. 517-520
    • Nishino, H.1    Koide, K.2    Aihara, N.3    Kumazaki, M.4    Sakurai, T.5    Nagai, H.6
  • 73
    • 0032562172 scopus 로고    scopus 로고
    • Early specification of striatal projection neurons and interneuronal subtypes in the lateral and medial ganglionic eminence
    • Olsson M., Björklund A., and Campbell K. Early specification of striatal projection neurons and interneuronal subtypes in the lateral and medial ganglionic eminence. Neuroscience 84 (1998) 867-876
    • (1998) Neuroscience , vol.84 , pp. 867-876
    • Olsson, M.1    Björklund, A.2    Campbell, K.3
  • 74
    • 0028884523 scopus 로고
    • Projection neurons in fetal striatal transplants are predominantly derived from the lateral ganglionic eminence
    • Olsson M., Campbell K., Wictorin K., and Björklund A. Projection neurons in fetal striatal transplants are predominantly derived from the lateral ganglionic eminence. Neuroscience 69 (1995) 1169-1182
    • (1995) Neuroscience , vol.69 , pp. 1169-1182
    • Olsson, M.1    Campbell, K.2    Wictorin, K.3    Björklund, A.4
  • 75
    • 0031724818 scopus 로고    scopus 로고
    • Endogenous retroviruses and the safety of porcine xenotransplantation
    • Onions D., Hart D., Mahoney C., Galbraith D., and Smith K. Endogenous retroviruses and the safety of porcine xenotransplantation. Trends Microbiol. 6 (1998) 430-431
    • (1998) Trends Microbiol. , vol.6 , pp. 430-431
    • Onions, D.1    Hart, D.2    Mahoney, C.3    Galbraith, D.4    Smith, K.5
  • 76
    • 0028952138 scopus 로고
    • A novel mode of immunoprotection of neural xenotransplants: masking of donor major histocompatibility complex class I enhances transplant survival in the central nervous system
    • Pakzaban P., Deacon T.W., Burns L.H., Dinsmore J., and Isacson O. A novel mode of immunoprotection of neural xenotransplants: masking of donor major histocompatibility complex class I enhances transplant survival in the central nervous system. Neuroscience 65 (1995) 983-996
    • (1995) Neuroscience , vol.65 , pp. 983-996
    • Pakzaban, P.1    Deacon, T.W.2    Burns, L.H.3    Dinsmore, J.4    Isacson, O.5
  • 77
    • 0027724863 scopus 로고
    • Increased proportion of acetylcholinesterase-rich zones and improved morphological integration in host striatum of fetal grafts derived from the lateral but not the medial ganglionic eminence
    • Pakzaban P., Deacon T.W., Burns L.H., and Isacson O. Increased proportion of acetylcholinesterase-rich zones and improved morphological integration in host striatum of fetal grafts derived from the lateral but not the medial ganglionic eminence. Exp. Brain Res. 97 (1993) 13-22
    • (1993) Exp. Brain Res. , vol.97 , pp. 13-22
    • Pakzaban, P.1    Deacon, T.W.2    Burns, L.H.3    Isacson, O.4
  • 82
    • 0029011778 scopus 로고
    • Rationale for intrastriatal grafting of striatal neuroblasts in patients with Huntington's disease
    • Peschanski M., Césaro P., and Hantraye P. Rationale for intrastriatal grafting of striatal neuroblasts in patients with Huntington's disease. Neuroscience 68 (1995) 273-285
    • (1995) Neuroscience , vol.68 , pp. 273-285
    • Peschanski, M.1    Césaro, P.2    Hantraye, P.3
  • 83
    • 0030068021 scopus 로고    scopus 로고
    • What is needed versus what would be interesting to know before undertaking neural transplantation in patients with Huntington's disease
    • Peschanski M., Césaro P., and Hantraye P. What is needed versus what would be interesting to know before undertaking neural transplantation in patients with Huntington's disease. Neuroscience 71 (1996) 899-900
    • (1996) Neuroscience , vol.71 , pp. 899-900
    • Peschanski, M.1    Césaro, P.2    Hantraye, P.3
  • 84
    • 0041737461 scopus 로고    scopus 로고
    • Cell therapy for Huntington's disease, the next step forward
    • Peschanski M., and Dunnett S.B. Cell therapy for Huntington's disease, the next step forward. Lancet Neurol. 1 2 (2002) 81
    • (2002) Lancet Neurol. , vol.1 , Issue.2 , pp. 81
    • Peschanski, M.1    Dunnett, S.B.2
  • 85
    • 0030953742 scopus 로고    scopus 로고
    • Neuropsychological functioning following fetal striatal transplantation in Huntington's chorea: three case presentations
    • Philpott L.M., Kopyov O.V., Lee A.J., Jacques S., Duma C.M., Caine S., Yang M., and Eagle K.S. Neuropsychological functioning following fetal striatal transplantation in Huntington's chorea: three case presentations. Cell Transplant. 6 (1997) 203-212
    • (1997) Cell Transplant. , vol.6 , pp. 203-212
    • Philpott, L.M.1    Kopyov, O.V.2    Lee, A.J.3    Jacques, S.4    Duma, C.M.5    Caine, S.6    Yang, M.7    Eagle, K.S.8
  • 89
    • 0034618649 scopus 로고    scopus 로고
    • Xenotransplantation-new risks, new gains
    • Platt J.L. Xenotransplantation-new risks, new gains. Nature 407 (2000) 27-30
    • (2000) Nature , vol.407 , pp. 27-30
    • Platt, J.L.1
  • 90
    • 33847679113 scopus 로고    scopus 로고
    • S. Polgar, J. Ng, Ethics, methodology and the use of placebo controls in surgical trials. Am. J. Bioethics, submitted for publication.
  • 92
    • 0023148062 scopus 로고
    • Afferent and efferent connections of striatal grafts implanted into the ibotenic acid lesioned neostriatum in adult rats
    • Pritzel M., Isacson O., Brundin P., Wiklund L., and Björklund A. Afferent and efferent connections of striatal grafts implanted into the ibotenic acid lesioned neostriatum in adult rats. Exp. Brain Res. 65 (1986) 112-126
    • (1986) Exp. Brain Res. , vol.65 , pp. 112-126
    • Pritzel, M.1    Isacson, O.2    Brundin, P.3    Wiklund, L.4    Björklund, A.5
  • 93
    • 0030029924 scopus 로고    scopus 로고
    • Transplantation of human striatal tissue into a rodent model of Huntington's disease: phenotypic expression of transplanted neurons and host-to-graft innervation
    • Pundt L.L., Kondoh T., Conrad J.A., and Low W.C. Transplantation of human striatal tissue into a rodent model of Huntington's disease: phenotypic expression of transplanted neurons and host-to-graft innervation. Brain Res. Bull. 39 (1996) 23-32
    • (1996) Brain Res. Bull. , vol.39 , pp. 23-32
    • Pundt, L.L.1    Kondoh, T.2    Conrad, J.A.3    Low, W.C.4
  • 94
    • 0025120490 scopus 로고
    • The clinical application of cell grafting techniques in patients with Parkinson's disease
    • Quinn N.P. The clinical application of cell grafting techniques in patients with Parkinson's disease. Prog. Brain Res. 82 (1990) 619-625
    • (1990) Prog. Brain Res. , vol.82 , pp. 619-625
    • Quinn, N.P.1
  • 98
    • 3142640821 scopus 로고    scopus 로고
    • Huntington's disease: new paths to pathogenesis
    • Ross C.A. Huntington's disease: new paths to pathogenesis. Cell 118 (2004) 4-7
    • (2004) Cell , vol.118 , pp. 4-7
    • Ross, C.A.1
  • 100
    • 0036904801 scopus 로고    scopus 로고
    • Unilateral transplantation of human primary fetal tissue in four patients with Huntington's disease: NEST-UK safety report (ISRCTN no. 36485475)
    • the NEST-UK consortium
    • Rosser A.E., Barker R.A., Guillard J., Harrower T., Watts C., Pickard J., Dunnett S.B., and the NEST-UK consortium. Unilateral transplantation of human primary fetal tissue in four patients with Huntington's disease: NEST-UK safety report (ISRCTN no. 36485475). J. Neurol. Neurosurg. Psychiatr. 73 (2002) 678-685
    • (2002) J. Neurol. Neurosurg. Psychiatr. , vol.73 , pp. 678-685
    • Rosser, A.E.1    Barker, R.A.2    Guillard, J.3    Harrower, T.4    Watts, C.5    Pickard, J.6    Dunnett, S.B.7
  • 102
    • 0025846973 scopus 로고
    • Effects of cool storage on survival and function of intrastriatal ventral mesencephalic grafts
    • Sauer H., and Brundin P. Effects of cool storage on survival and function of intrastriatal ventral mesencephalic grafts. Rest. Neurol. Neurosci. 2 (1991) 123-135
    • (1991) Rest. Neurol. Neurosci. , vol.2 , pp. 123-135
    • Sauer, H.1    Brundin, P.2
  • 103
    • 0027342934 scopus 로고
    • 18F]-6-l-fluorodopa PET studies of graft and host dopaminergic function following fetal mesencephalic transplantation
    • 18F]-6-l-fluorodopa PET studies of graft and host dopaminergic function following fetal mesencephalic transplantation. Adv. Neurol. 60 (1993) 715-720
    • (1993) Adv. Neurol. , vol.60 , pp. 715-720
    • Sawle, G.V.1
  • 104
    • 0027411599 scopus 로고
    • The role of positron emission tomography in the assessment of human neurotransplantation
    • Sawle G.V., and Myers R. The role of positron emission tomography in the assessment of human neurotransplantation. Trends Neurosci. 16 (1993) 172-176
    • (1993) Trends Neurosci. , vol.16 , pp. 172-176
    • Sawle, G.V.1    Myers, R.2
  • 106
    • 0019448060 scopus 로고
    • Intracerebral grafting of dissociated CNS tissue suspensions: a new approach for neuronal transplantation to deep brain sites
    • Schmidt R.H., Björklund A., and Stenevi U. Intracerebral grafting of dissociated CNS tissue suspensions: a new approach for neuronal transplantation to deep brain sites. Brain Res. 218 (1981) 347-356
    • (1981) Brain Res. , vol.218 , pp. 347-356
    • Schmidt, R.H.1    Björklund, A.2    Stenevi, U.3
  • 108
    • 0020702374 scopus 로고
    • Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain
    • Schwarcz R., Whetsell W.O., and Mangano R.M. Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain. Science 219 (1983) 316-318
    • (1983) Science , vol.219 , pp. 316-318
    • Schwarcz, R.1    Whetsell, W.O.2    Mangano, R.M.3
  • 109
    • 0029865022 scopus 로고    scopus 로고
    • Neural transplantation for Huntington's disease: experimental rationale and recommendations for clinical trials
    • Shannon K.M., and Kordower J.H. Neural transplantation for Huntington's disease: experimental rationale and recommendations for clinical trials. Cell Transplant. 5 (1996) 339-352
    • (1996) Cell Transplant. , vol.5 , pp. 339-352
    • Shannon, K.M.1    Kordower, J.H.2
  • 110
    • 0002496113 scopus 로고
    • Ontogeny of the neostriatum
    • Divac I., and Öberg R.G.E. (Eds), Pergamon Press, New York
    • Smart I.H.M., and Sturrock R.R. Ontogeny of the neostriatum. In: Divac I., and Öberg R.G.E. (Eds). The Neostriatum (1979), Pergamon Press, New York 127-146
    • (1979) The Neostriatum , pp. 127-146
    • Smart, I.H.M.1    Sturrock, R.R.2
  • 111
    • 0024991688 scopus 로고
    • Remodeling of intrinsic and afferent systems in neocortex with cortical transplants
    • Sofroniew M.V., Dunnett S.B., and Isacson O. Remodeling of intrinsic and afferent systems in neocortex with cortical transplants. Prog. Brain Res. 82 (1990) 313-320
    • (1990) Prog. Brain Res. , vol.82 , pp. 313-320
    • Sofroniew, M.V.1    Dunnett, S.B.2    Isacson, O.3
  • 112
    • 0026787932 scopus 로고
    • Stereotactic technique and pathophysiological mechanisms of neurotransplantation in Huntington's chorea
    • Sramka M., Rattaj M., Molina H., Vojtassak J., Belan V., and Ruzicky E. Stereotactic technique and pathophysiological mechanisms of neurotransplantation in Huntington's chorea. Stereotact. Funct. Neurosurg. 58 (1992) 79-83
    • (1992) Stereotact. Funct. Neurosurg. , vol.58 , pp. 79-83
    • Sramka, M.1    Rattaj, M.2    Molina, H.3    Vojtassak, J.4    Belan, V.5    Ruzicky, E.6
  • 113
    • 0017158756 scopus 로고
    • Transplantation of central and peripheral monoamine neurons to the adult rat brain: techniques and conditions for survival
    • Stenevi U., Björklund A., and Svendgaard N.-A. Transplantation of central and peripheral monoamine neurons to the adult rat brain: techniques and conditions for survival. Brain Res. 114 (1976) 1-20
    • (1976) Brain Res. , vol.114 , pp. 1-20
    • Stenevi, U.1    Björklund, A.2    Svendgaard, N.-A.3
  • 116
    • 0033838272 scopus 로고    scopus 로고
    • The morphology, integration and functional efficacy of striatal grafts differs between cell suspensions and tissue pieces
    • Watts C., Brasted P.J., and Dunnett S.B. The morphology, integration and functional efficacy of striatal grafts differs between cell suspensions and tissue pieces. Cell Transplant. 9 (2000) 395-407
    • (2000) Cell Transplant. , vol.9 , pp. 395-407
    • Watts, C.1    Brasted, P.J.2    Dunnett, S.B.3
  • 117
    • 0034064954 scopus 로고    scopus 로고
    • Embryonic donor age and dissection influence striatal graft development and functional integration in a rodent model of Huntington's disease
    • Watts C., Brasted P.J., Eagle D.M., and Dunnett S.B. Embryonic donor age and dissection influence striatal graft development and functional integration in a rodent model of Huntington's disease. Exp. Neurol. 163 (2000) 85-97
    • (2000) Exp. Neurol. , vol.163 , pp. 85-97
    • Watts, C.1    Brasted, P.J.2    Eagle, D.M.3    Dunnett, S.B.4
  • 119
    • 0026603230 scopus 로고
    • Anatomy and connectivity of intrastriatal striatal transplants
    • Wictorin K. Anatomy and connectivity of intrastriatal striatal transplants. Prog. Neurobiol. 38 (1992) 611-639
    • (1992) Prog. Neurobiol. , vol.38 , pp. 611-639
    • Wictorin, K.1
  • 120
    • 0024382430 scopus 로고
    • Connectivity of striatal grafts implanted into the ibotenic acid-lesioned striatum. 2: Cortical afferents
    • Wictorin K., and Björklund A. Connectivity of striatal grafts implanted into the ibotenic acid-lesioned striatum. 2: Cortical afferents. Neuroscience 30 (1989) 297-311
    • (1989) Neuroscience , vol.30 , pp. 297-311
    • Wictorin, K.1    Björklund, A.2
  • 121
    • 0023698295 scopus 로고
    • Connectivity of striatal grafts implanted into the ibotenic acid-lesioned striatum. 1: Subcortical afferents
    • Wictorin K., Isacson O., Fischer W., Nothias F., Peschanski M., and Björklund A. Connectivity of striatal grafts implanted into the ibotenic acid-lesioned striatum. 1: Subcortical afferents. Neuroscience 27 (1988) 547-562
    • (1988) Neuroscience , vol.27 , pp. 547-562
    • Wictorin, K.1    Isacson, O.2    Fischer, W.3    Nothias, F.4    Peschanski, M.5    Björklund, A.6
  • 122
    • 0024337519 scopus 로고
    • Connectivity of striatal grafts implanted into the ibotenic acid-lesioned striatum. 3: Efferent projecting graft neurons and their relation to host afferents within the grafts
    • Wictorin K., Simerly R.B., Isacson O., Swanson L.W., and Björklund A. Connectivity of striatal grafts implanted into the ibotenic acid-lesioned striatum. 3: Efferent projecting graft neurons and their relation to host afferents within the grafts. Neuroscience 30 (1989) 313-330
    • (1989) Neuroscience , vol.30 , pp. 313-330
    • Wictorin, K.1    Simerly, R.B.2    Isacson, O.3    Swanson, L.W.4    Björklund, A.5


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