-
1
-
-
23044514669
-
Epigenetic differences arise during the lifetime of monozygotic twins
-
Fraga M.F., et al. Epigenetic differences arise during the lifetime of monozygotic twins. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:10604-10609.
-
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, pp. 10604-10609
-
-
Fraga, M.F.1
-
2
-
-
53549123008
-
Nature, nurture, or chance: stochastic gene expression and its consequences
-
Raj A., van Oudenaarden A. Nature, nurture, or chance: stochastic gene expression and its consequences. Cell 2008, 135:216-226.
-
(2008)
Cell
, vol.135
, pp. 216-226
-
-
Raj, A.1
van Oudenaarden, A.2
-
3
-
-
33750174645
-
Epistatic interactions: how strong in disease and evolution?
-
Azevedo L., et al. Epistatic interactions: how strong in disease and evolution?. Trends Genet. 2006, 22:581-585.
-
(2006)
Trends Genet.
, vol.22
, pp. 581-585
-
-
Azevedo, L.1
-
4
-
-
0037069428
-
Dobzhansky-Muller incompatibilities in protein evolution
-
Kondrashov A.S., et al. Dobzhansky-Muller incompatibilities in protein evolution. Proc. Natl. Acad. Sci. U.S.A. 2002, 99:14878-14883.
-
(2002)
Proc. Natl. Acad. Sci. U.S.A.
, vol.99
, pp. 14878-14883
-
-
Kondrashov, A.S.1
-
5
-
-
9444269272
-
Compensated deleterious mutations in insect genomes
-
Kulathinal R.J., et al. Compensated deleterious mutations in insect genomes. Science 2004, 306:1553-1554.
-
(2004)
Science
, vol.306
, pp. 1553-1554
-
-
Kulathinal, R.J.1
-
6
-
-
77951530523
-
Genotype to phenotype: a complex problem
-
Dowell R.D., et al. Genotype to phenotype: a complex problem. Science 2010, 328:469.
-
(2010)
Science
, vol.328
, pp. 469
-
-
Dowell, R.D.1
-
8
-
-
3442894519
-
Epistasis: too often neglected in complex trait studies?
-
Carlborg O., Haley C.S. Epistasis: too often neglected in complex trait studies?. Nat. Rev. Genet. 2004, 5:618-625.
-
(2004)
Nat. Rev. Genet.
, vol.5
, pp. 618-625
-
-
Carlborg, O.1
Haley, C.S.2
-
9
-
-
67349166946
-
Detecting gene-gene interactions that underlie human diseases
-
Cordell H.J. Detecting gene-gene interactions that underlie human diseases. Nat. Rev. Genet. 2009, 10:392-404.
-
(2009)
Nat. Rev. Genet.
, vol.10
, pp. 392-404
-
-
Cordell, H.J.1
-
10
-
-
0031827525
-
The language of gene interaction
-
Phillips P.C. The language of gene interaction. Genetics 1998, 149:1167-1171.
-
(1998)
Genetics
, vol.149
, pp. 1167-1171
-
-
Phillips, P.C.1
-
11
-
-
54149088214
-
Epistasis-the essential role of gene interactions in the structure and evolution of genetic systems
-
Phillips P.C. Epistasis-the essential role of gene interactions in the structure and evolution of genetic systems. Nat. Rev. Genet. 2008, 9:855-867.
-
(2008)
Nat. Rev. Genet.
, vol.9
, pp. 855-867
-
-
Phillips, P.C.1
-
12
-
-
21044438202
-
The rate of compensatory mutation in the DNA bacteriophage phiX174
-
Poon A., Chao L. The rate of compensatory mutation in the DNA bacteriophage phiX174. Genetics 2005, 170:989-999.
-
(2005)
Genetics
, vol.170
, pp. 989-999
-
-
Poon, A.1
Chao, L.2
-
13
-
-
84975742565
-
A map of human genome variation from population-scale sequencing
-
Durbin R.M., et al. A map of human genome variation from population-scale sequencing. Nature 2010, 467:1061-1073.
-
(2010)
Nature
, vol.467
, pp. 1061-1073
-
-
Durbin, R.M.1
-
14
-
-
62649089109
-
Population genomics of domestic and wild yeasts
-
Liti G., et al. Population genomics of domestic and wild yeasts. Nature 2009, 458:337-341.
-
(2009)
Nature
, vol.458
, pp. 337-341
-
-
Liti, G.1
-
15
-
-
66049159816
-
Genetic architecture of quantitative traits in mice, flies, and humans
-
Flint J., Mackay T.F. Genetic architecture of quantitative traits in mice, flies, and humans. Genome Res. 2009, 19:723-733.
-
(2009)
Genome Res.
, vol.19
, pp. 723-733
-
-
Flint, J.1
Mackay, T.F.2
-
16
-
-
0035830860
-
Principles for the buffering of genetic variation
-
Hartman J.L.t., et al. Principles for the buffering of genetic variation. Science 2001, 291:1001-1004.
-
(2001)
Science
, vol.291
, pp. 1001-1004
-
-
Hartman, J.1
-
17
-
-
67651108806
-
The genetics of quantitative traits: challenges and prospects
-
Mackay T.F., et al. The genetics of quantitative traits: challenges and prospects. Nat. Rev. Genet. 2009, 10:565-577.
-
(2009)
Nat. Rev. Genet.
, vol.10
, pp. 565-577
-
-
Mackay, T.F.1
-
18
-
-
28444467392
-
Quantitative trait loci mapped to single-nucleotide resolution in yeast
-
Deutschbauer A.M., Davis R.W. Quantitative trait loci mapped to single-nucleotide resolution in yeast. Nat. Genet. 2005, 37:1333-1340.
-
(2005)
Nat. Genet.
, vol.37
, pp. 1333-1340
-
-
Deutschbauer, A.M.1
Davis, R.W.2
-
19
-
-
58849139595
-
Genetic interactions between transcription factors cause natural variation in yeast
-
Gerke J., et al. Genetic interactions between transcription factors cause natural variation in yeast. Science 2009, 323:498-501.
-
(2009)
Science
, vol.323
, pp. 498-501
-
-
Gerke, J.1
-
20
-
-
33644770200
-
Negative epistasis between natural variants of the Saccharomyces cerevisiae MLH1 and PMS1 genes results in a defect in mismatch repair
-
Heck J.A., et al. Negative epistasis between natural variants of the Saccharomyces cerevisiae MLH1 and PMS1 genes results in a defect in mismatch repair. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:3256-3261.
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 3256-3261
-
-
Heck, J.A.1
-
21
-
-
18344382775
-
Epistasis and balanced polymorphism influencing complex trait variation
-
Kroymann J., Mitchell-Olds T. Epistasis and balanced polymorphism influencing complex trait variation. Nature 2005, 435:95-98.
-
(2005)
Nature
, vol.435
, pp. 95-98
-
-
Kroymann, J.1
Mitchell-Olds, T.2
-
22
-
-
0032734337
-
Quantitative trait loci affecting survival and fertility-related traits in Caenorhabditis elegans show genotype-environment interactions, pleiotropy and epistasis
-
Shook D.R., Johnson T.E. Quantitative trait loci affecting survival and fertility-related traits in Caenorhabditis elegans show genotype-environment interactions, pleiotropy and epistasis. Genetics 1999, 153:1233-1243.
-
(1999)
Genetics
, vol.153
, pp. 1233-1243
-
-
Shook, D.R.1
Johnson, T.E.2
-
23
-
-
38849199286
-
Widespread genetic incompatibility in C. elegans maintained by balancing selection
-
Seidel H.S., et al. Widespread genetic incompatibility in C. elegans maintained by balancing selection. Science 2008, 319:589-594.
-
(2008)
Science
, vol.319
, pp. 589-594
-
-
Seidel, H.S.1
-
24
-
-
0242286604
-
Mapping determinants of variation in energy metabolism, respiration and flight in Drosophila
-
Montooth K.L., et al. Mapping determinants of variation in energy metabolism, respiration and flight in Drosophila. Genetics 2003, 165:623-635.
-
(2003)
Genetics
, vol.165
, pp. 623-635
-
-
Montooth, K.L.1
-
25
-
-
4644370178
-
Extensive sex-specific nonadditivity of gene expression in Drosophila melanogaster
-
Gibson G., et al. Extensive sex-specific nonadditivity of gene expression in Drosophila melanogaster. Genetics 2004, 167:1791-1799.
-
(2004)
Genetics
, vol.167
, pp. 1791-1799
-
-
Gibson, G.1
-
26
-
-
33645381715
-
Epistasis and the release of genetic variation during long-term selection
-
Carlborg O., et al. Epistasis and the release of genetic variation during long-term selection. Nat. Genet. 2006, 38:418-420.
-
(2006)
Nat. Genet.
, vol.38
, pp. 418-420
-
-
Carlborg, O.1
-
27
-
-
58149396842
-
Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis
-
Shao H., et al. Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:19910-19914.
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 19910-19914
-
-
Shao, H.1
-
28
-
-
30744473697
-
Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci
-
Stylianou I.M., et al. Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci. Mamm. Genome 2006, 17:22-36.
-
(2006)
Mamm. Genome
, vol.17
, pp. 22-36
-
-
Stylianou, I.M.1
-
29
-
-
31544444132
-
Epistatic pleiotropy and the genetic architecture of covariation within early and late-developing skull trait complexes in mice
-
Wolf J.B., et al. Epistatic pleiotropy and the genetic architecture of covariation within early and late-developing skull trait complexes in mice. Genetics 2005, 171:683-694.
-
(2005)
Genetics
, vol.171
, pp. 683-694
-
-
Wolf, J.B.1
-
30
-
-
23644434284
-
Genetic interactions between polymorphisms that affect gene expression in yeast
-
Brem R.B., et al. Genetic interactions between polymorphisms that affect gene expression in yeast. Nature 2005, 436:701-703.
-
(2005)
Nature
, vol.436
, pp. 701-703
-
-
Brem, R.B.1
-
31
-
-
73349095048
-
Systematic mapping of genetic interaction networks
-
Dixon S.J., et al. Systematic mapping of genetic interaction networks. Annu. Rev. Genet. 2009, 43:601-625.
-
(2009)
Annu. Rev. Genet.
, vol.43
, pp. 601-625
-
-
Dixon, S.J.1
-
32
-
-
34249732505
-
Modelling genotype-phenotype relationships and human disease with genetic interaction networks
-
Lehner B. Modelling genotype-phenotype relationships and human disease with genetic interaction networks. J. Exp. Biol. 2007, 210:1559-1566.
-
(2007)
J. Exp. Biol.
, vol.210
, pp. 1559-1566
-
-
Lehner, B.1
-
33
-
-
34848834757
-
A global analysis of genetic interactions in Caenorhabditis elegans
-
Byrne A.B., et al. A global analysis of genetic interactions in Caenorhabditis elegans. J. Biol. 2007, 6:8.
-
(2007)
J. Biol.
, vol.6
, pp. 8
-
-
Byrne, A.B.1
-
34
-
-
75649111192
-
The genetic landscape of a cell
-
Costanzo M., et al. The genetic landscape of a cell. Science 2010, 327:425-431.
-
(2010)
Science
, vol.327
, pp. 425-431
-
-
Costanzo, M.1
-
35
-
-
33746525415
-
Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways
-
Lehner B., et al. Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways. Nat. Genet. 2006, 38:896-903.
-
(2006)
Nat. Genet.
, vol.38
, pp. 896-903
-
-
Lehner, B.1
-
36
-
-
33644778778
-
A DNA integrity network in the yeast Saccharomyces cerevisiae
-
Pan X., et al. A DNA integrity network in the yeast Saccharomyces cerevisiae. Cell 2006, 124:1069-1081.
-
(2006)
Cell
, vol.124
, pp. 1069-1081
-
-
Pan, X.1
-
37
-
-
26844489762
-
Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile
-
Schuldiner M., et al. Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile. Cell 2005, 123:507-519.
-
(2005)
Cell
, vol.123
, pp. 507-519
-
-
Schuldiner, M.1
-
38
-
-
10744230485
-
Global mapping of the yeast genetic interaction network
-
Tong A.H., et al. Global mapping of the yeast genetic interaction network. Science 2004, 303:808-813.
-
(2004)
Science
, vol.303
, pp. 808-813
-
-
Tong, A.H.1
-
39
-
-
33846581918
-
Statistical epistasis is a generic feature of gene regulatory networks
-
Gjuvsland A.B., et al. Statistical epistasis is a generic feature of gene regulatory networks. Genetics 2007, 175:411-420.
-
(2007)
Genetics
, vol.175
, pp. 411-420
-
-
Gjuvsland, A.B.1
-
40
-
-
33846317719
-
Compensatory evolution reveals functional interactions between ribosomal proteins S12, L14 and L19
-
Maisnier-Patin S., et al. Compensatory evolution reveals functional interactions between ribosomal proteins S12, L14 and L19. J. Mol. Biol. 2007, 366:207-215.
-
(2007)
J. Mol. Biol.
, vol.366
, pp. 207-215
-
-
Maisnier-Patin, S.1
-
41
-
-
0036898532
-
Rapid coevolution of the nematode sex-determining genes fem-3 and tra-2
-
Haag E.S., et al. Rapid coevolution of the nematode sex-determining genes fem-3 and tra-2. Curr. Biol. 2002, 12:2035-2041.
-
(2002)
Curr. Biol.
, vol.12
, pp. 2035-2041
-
-
Haag, E.S.1
-
42
-
-
48249132857
-
Pervasive and persistent redundancy among duplicated genes in yeast
-
Dean E.J., et al. Pervasive and persistent redundancy among duplicated genes in yeast. PLoS Genet. 2008, 4:e1000113.
-
(2008)
PLoS Genet.
, vol.4
-
-
Dean, E.J.1
-
43
-
-
46449094817
-
The extensive and condition-dependent nature of epistasis among whole-genome duplicates in yeast
-
Musso G., et al. The extensive and condition-dependent nature of epistasis among whole-genome duplicates in yeast. Genome Res. 2008, 18:1092-1099.
-
(2008)
Genome Res.
, vol.18
, pp. 1092-1099
-
-
Musso, G.1
-
44
-
-
33749125656
-
Combinatorial RNA interference in Caenorhabditis elegans reveals that redundancy between gene duplicates can be maintained for more than 80 million years of evolution
-
Tischler J., et al. Combinatorial RNA interference in Caenorhabditis elegans reveals that redundancy between gene duplicates can be maintained for more than 80 million years of evolution. Genome Biol. 2006, 7:R69.
-
(2006)
Genome Biol.
, vol.7
-
-
Tischler, J.1
-
45
-
-
33947617347
-
Backup without redundancy: genetic interactions reveal the cost of duplicate gene loss
-
Ihmels J., et al. Backup without redundancy: genetic interactions reveal the cost of duplicate gene loss. Mol. Syst. Biol. 2007, 3:86.
-
(2007)
Mol. Syst. Biol.
, vol.3
, pp. 86
-
-
Ihmels, J.1
-
46
-
-
78449272957
-
Genetic interactions reveal the evolutionary trajectories of duplicate genes
-
VanderSluis B., et al. Genetic interactions reveal the evolutionary trajectories of duplicate genes. Mol. Syst. Biol. 2010, 6:429.
-
(2010)
Mol. Syst. Biol.
, vol.6
, pp. 429
-
-
VanderSluis, B.1
-
47
-
-
14344263352
-
Distributed robustness versus redundancy as causes of mutational robustness
-
Wagner A. Distributed robustness versus redundancy as causes of mutational robustness. Bioessays 2005, 27:176-188.
-
(2005)
Bioessays
, vol.27
, pp. 176-188
-
-
Wagner, A.1
-
48
-
-
15044353444
-
Transcription control reprogramming in genetic backup circuits
-
Kafri R., et al. Transcription control reprogramming in genetic backup circuits. Nat. Genet. 2005, 37:295-299.
-
(2005)
Nat. Genet.
, vol.37
, pp. 295-299
-
-
Kafri, R.1
-
49
-
-
78649938122
-
Functional overlap and regulatory links shape genetic interactions between signaling pathways
-
van Wageningen S., et al. Functional overlap and regulatory links shape genetic interactions between signaling pathways. Cell 2010, 143:991-1004.
-
(2010)
Cell
, vol.143
, pp. 991-1004
-
-
van Wageningen, S.1
-
50
-
-
59049099861
-
Genetic redundancy: new tricks for old genes
-
Kafri R., et al. Genetic redundancy: new tricks for old genes. Cell 2009, 136:389-392.
-
(2009)
Cell
, vol.136
, pp. 389-392
-
-
Kafri, R.1
-
51
-
-
2942624207
-
Metabolic network analysis of the causes and evolution of enzyme dispensability in yeast
-
Papp B., et al. Metabolic network analysis of the causes and evolution of enzyme dispensability in yeast. Nature 2004, 429:661-664.
-
(2004)
Nature
, vol.429
, pp. 661-664
-
-
Papp, B.1
-
52
-
-
78649705725
-
Quantitative analysis of fitness and genetic interactions in yeast on a genome scale
-
Baryshnikova A., et al. Quantitative analysis of fitness and genetic interactions in yeast on a genome scale. Nat. Methods 2010, 7:1017-1024.
-
(2010)
Nat. Methods
, vol.7
, pp. 1017-1024
-
-
Baryshnikova, A.1
-
53
-
-
22844450110
-
Systematic interpretation of genetic interactions using protein networks
-
Kelley R., Ideker T. Systematic interpretation of genetic interactions using protein networks. Nat. Biotechnol. 2005, 23:561-566.
-
(2005)
Nat. Biotechnol.
, vol.23
, pp. 561-566
-
-
Kelley, R.1
Ideker, T.2
-
54
-
-
77954760095
-
Predicting genetic modifier loci using functional gene networks
-
Lee I., et al. Predicting genetic modifier loci using functional gene networks. Genome Res. 2010, 20:1143-1153.
-
(2010)
Genome Res.
, vol.20
, pp. 1143-1153
-
-
Lee, I.1
-
56
-
-
8144227773
-
Combining biological networks to predict genetic interactions
-
Wong S.L., et al. Combining biological networks to predict genetic interactions. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:15682-15687.
-
(2004)
Proc. Natl. Acad. Sci. U.S.A.
, vol.101
, pp. 15682-15687
-
-
Wong, S.L.1
-
57
-
-
34247193051
-
Pathway redundancy and protein essentiality revealed in the Saccharomyces cerevisiae interaction networks
-
Ulitsky I., Shamir R. Pathway redundancy and protein essentiality revealed in the Saccharomyces cerevisiae interaction networks. Mol. Syst. Biol. 2007, 3:104.
-
(2007)
Mol. Syst. Biol.
, vol.3
, pp. 104
-
-
Ulitsky, I.1
Shamir, R.2
-
58
-
-
41349102391
-
Evolutionary plasticity of genetic interaction networks
-
Tischler J., et al. Evolutionary plasticity of genetic interaction networks. Nat. Genet. 2008, 40:390-391.
-
(2008)
Nat. Genet.
, vol.40
, pp. 390-391
-
-
Tischler, J.1
-
59
-
-
43249117094
-
Functional maps of protein complexes from quantitative genetic interaction data
-
Bandyopadhyay S., et al. Functional maps of protein complexes from quantitative genetic interaction data. PLoS Comput. Biol. 2008, 4:e1000065.
-
(2008)
PLoS Comput. Biol.
, vol.4
-
-
Bandyopadhyay, S.1
-
60
-
-
34147217542
-
Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map
-
Collins S.R., et al. Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature 2007, 446:806-810.
-
(2007)
Nature
, vol.446
, pp. 806-810
-
-
Collins, S.R.1
-
61
-
-
33846604202
-
Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions
-
St Onge R.P., et al. Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions. Nat. Genet. 2007, 39:199-206.
-
(2007)
Nat. Genet.
, vol.39
, pp. 199-206
-
-
St Onge, R.P.1
-
62
-
-
38449085963
-
Genetic dissection of developmental pathways
-
Huang L.S., Sternberg P.W. Genetic dissection of developmental pathways. WormBook 2006, 1-19.
-
(2006)
WormBook
, pp. 1-19
-
-
Huang, L.S.1
Sternberg, P.W.2
-
63
-
-
11244297914
-
Modular epistasis in yeast metabolism
-
Segre D., et al. Modular epistasis in yeast metabolism. Nat. Genet. 2005, 37:77-83.
-
(2005)
Nat. Genet.
, vol.37
, pp. 77-83
-
-
Segre, D.1
-
64
-
-
0032569851
-
Hsp90 as a capacitor for morphological evolution
-
Rutherford S.L., Lindquist S. Hsp90 as a capacitor for morphological evolution. Nature 1998, 396:336-342.
-
(1998)
Nature
, vol.396
, pp. 336-342
-
-
Rutherford, S.L.1
Lindquist, S.2
-
65
-
-
0037030713
-
Hsp90 as a capacitor of phenotypic variation
-
Queitsch C., et al. Hsp90 as a capacitor of phenotypic variation. Nature 2002, 417:618-624.
-
(2002)
Nature
, vol.417
, pp. 618-624
-
-
Queitsch, C.1
-
66
-
-
20044382800
-
Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone
-
Zhao R., et al. Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone. Cell 2005, 120:715-727.
-
(2005)
Cell
, vol.120
, pp. 715-727
-
-
Zhao, R.1
-
67
-
-
27144434505
-
The synthetic genetic interaction spectrum of essential genes
-
Davierwala A.P., et al. The synthetic genetic interaction spectrum of essential genes. Nat. Genet. 2005, 37:1147-1152.
-
(2005)
Nat. Genet.
, vol.37
, pp. 1147-1152
-
-
Davierwala, A.P.1
-
68
-
-
77949386270
-
Genes confer similar robustness to environmental, stochastic, and genetic perturbations in yeast
-
Lehner B. Genes confer similar robustness to environmental, stochastic, and genetic perturbations in yeast. PLoS ONE 2010, 5:e9035.
-
(2010)
PLoS ONE
, vol.5
-
-
Lehner, B.1
-
69
-
-
56849091295
-
Network hubs buffer environmental variation in Saccharomyces cerevisiae
-
Levy S.F., Siegal M.L. Network hubs buffer environmental variation in Saccharomyces cerevisiae. PLoS Biol. 2008, 6:e264.
-
(2008)
PLoS Biol.
, vol.6
-
-
Levy, S.F.1
Siegal, M.L.2
-
70
-
-
51149203927
-
Canalization of development and the inheritance of acquired characters
-
Waddington C.H. Canalization of development and the inheritance of acquired characters. Nature 1942, 150:563-565.
-
(1942)
Nature
, vol.150
, pp. 563-565
-
-
Waddington, C.H.1
-
71
-
-
0030087518
-
Epistasis and pleiotropy as natural properties of transcriptional regulation
-
Gibson G. Epistasis and pleiotropy as natural properties of transcriptional regulation. Theor. Popul. Biol. 1996, 49:58-89.
-
(1996)
Theor. Popul. Biol.
, vol.49
, pp. 58-89
-
-
Gibson, G.1
-
72
-
-
0002878320
-
Physiological and evolutionary theories of dominance
-
Wright S. Physiological and evolutionary theories of dominance. Am. Nat. 1934, 68:24-53.
-
(1934)
Am. Nat.
, vol.68
, pp. 24-53
-
-
Wright, S.1
-
73
-
-
33947640043
-
Prediction of phenotype and gene expression for combinations of mutations
-
Carter G.W., et al. Prediction of phenotype and gene expression for combinations of mutations. Mol. Syst. Biol. 2007, 3:96.
-
(2007)
Mol. Syst. Biol.
, vol.3
, pp. 96
-
-
Carter, G.W.1
-
74
-
-
72549097005
-
Epistasis in a quantitative trait captured by a molecular model of transcription factor interactions
-
Gertz J., et al. Epistasis in a quantitative trait captured by a molecular model of transcription factor interactions. Theor. Popul. Biol. 2010, 77:1-5.
-
(2010)
Theor. Popul. Biol.
, vol.77
, pp. 1-5
-
-
Gertz, J.1
-
75
-
-
33845864966
-
Robustness-epistasis link shapes the fitness landscape of a randomly drifting protein
-
Bershtein S., et al. Robustness-epistasis link shapes the fitness landscape of a randomly drifting protein. Nature 2006, 444:929-932.
-
(2006)
Nature
, vol.444
, pp. 929-932
-
-
Bershtein, S.1
-
76
-
-
79955423458
-
A systems analysis of mutational effects in HIV-1 protease and reverse transcriptase
-
Hinkley T., et al. A systems analysis of mutational effects in HIV-1 protease and reverse transcriptase. Nat. Genet. 2011, 43:487-489.
-
(2011)
Nat. Genet.
, vol.43
, pp. 487-489
-
-
Hinkley, T.1
-
77
-
-
79952270576
-
Prevalence of epistasis in the evolution of influenza a surface proteins
-
Kryazhimskiy S., et al. Prevalence of epistasis in the evolution of influenza a surface proteins. PLoS Genet. 2011, 7:e1001301.
-
(2011)
PLoS Genet.
, vol.7
-
-
Kryazhimskiy, S.1
-
78
-
-
78449233935
-
Pervasive cryptic epistasis in molecular evolution
-
Lunzer M., et al. Pervasive cryptic epistasis in molecular evolution. PLoS Genet. 2010, 6:e1001162.
-
(2010)
PLoS Genet.
, vol.6
-
-
Lunzer, M.1
-
79
-
-
34548040966
-
Crystal structure of an ancient protein: evolution by conformational epistasis
-
Ortlund E.A., et al. Crystal structure of an ancient protein: evolution by conformational epistasis. Science 2007, 317:1544-1548.
-
(2007)
Science
, vol.317
, pp. 1544-1548
-
-
Ortlund, E.A.1
-
80
-
-
34347258931
-
Conversion and compensatory evolution of the gamma-crystallin genes and identification of a cataractogenic mutation that reverses the sequence of the human CRYGD gene to an ancestral state
-
Plotnikova O.V., et al. Conversion and compensatory evolution of the gamma-crystallin genes and identification of a cataractogenic mutation that reverses the sequence of the human CRYGD gene to an ancestral state. Am. J. Hum. Genet. 2007, 81:32-43.
-
(2007)
Am. J. Hum. Genet.
, vol.81
, pp. 32-43
-
-
Plotnikova, O.V.1
-
81
-
-
77953718211
-
Sequence space and the ongoing expansion of the protein universe
-
Povolotskaya I.S., Kondrashov F.A. Sequence space and the ongoing expansion of the protein universe. Nature 2010, 465:922-926.
-
(2010)
Nature
, vol.465
, pp. 922-926
-
-
Povolotskaya, I.S.1
Kondrashov, F.A.2
-
82
-
-
33645666942
-
Darwinian evolution can follow only very few mutational paths to fitter proteins
-
Weinreich D.M., et al. Darwinian evolution can follow only very few mutational paths to fitter proteins. Science 2006, 312:111-114.
-
(2006)
Science
, vol.312
, pp. 111-114
-
-
Weinreich, D.M.1
-
83
-
-
16544384596
-
Mechanisms and convergence of compensatory evolution in mammalian mitochondrial tRNAs
-
Kern A.D., Kondrashov F.A. Mechanisms and convergence of compensatory evolution in mammalian mitochondrial tRNAs. Nat. Genet. 2004, 36:1207-1212.
-
(2004)
Nat. Genet.
, vol.36
, pp. 1207-1212
-
-
Kern, A.D.1
Kondrashov, F.A.2
-
84
-
-
40149099484
-
How protein stability and new functions trade off
-
Tokuriki N., et al. How protein stability and new functions trade off. PLoS Comput. Biol. 2008, 4:e1000002.
-
(2008)
PLoS Comput. Biol.
, vol.4
-
-
Tokuriki, N.1
-
85
-
-
0036295508
-
Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs
-
Wang X., et al. Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs. J. Mol. Biol. 2002, 320:85-95.
-
(2002)
J. Mol. Biol.
, vol.320
, pp. 85-95
-
-
Wang, X.1
-
86
-
-
0019869334
-
The molecular basis of dominance
-
Kacser H., Burns J.A. The molecular basis of dominance. Genetics 1981, 97:639-666.
-
(1981)
Genetics
, vol.97
, pp. 639-666
-
-
Kacser, H.1
Burns, J.A.2
-
87
-
-
27144538817
-
The biochemical architecture of an ancient adaptive landscape
-
Lunzer M., et al. The biochemical architecture of an ancient adaptive landscape. Science 2005, 310:499-501.
-
(2005)
Science
, vol.310
, pp. 499-501
-
-
Lunzer, M.1
-
88
-
-
51649110669
-
A compromise required by gene sharing enables survival: Implications for evolution of new enzyme activities
-
McLoughlin S.Y., Copley S.D. A compromise required by gene sharing enables survival: Implications for evolution of new enzyme activities. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:13497-13502.
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 13497-13502
-
-
McLoughlin, S.Y.1
Copley, S.D.2
-
89
-
-
77956637258
-
Amplification of the gene for isoleucyl-tRNA synthetase facilitates adaptation to the fitness cost of mupirocin resistance in Salmonella enterica
-
Paulander W., et al. Amplification of the gene for isoleucyl-tRNA synthetase facilitates adaptation to the fitness cost of mupirocin resistance in Salmonella enterica. Genetics 2010, 185:305-312.
-
(2010)
Genetics
, vol.185
, pp. 305-312
-
-
Paulander, W.1
-
90
-
-
0036239186
-
Dependence of epistasis on environment and mutation severity as revealed by in silico mutagenesis of phage t7
-
You L., Yin J. Dependence of epistasis on environment and mutation severity as revealed by in silico mutagenesis of phage t7. Genetics 2002, 160:1273-1281.
-
(2002)
Genetics
, vol.160
, pp. 1273-1281
-
-
You, L.1
Yin, J.2
-
91
-
-
1842483226
-
Pervasive joint influence of epistasis and plasticity on mutational effects in Escherichia coli
-
Remold S.K., Lenski R.E. Pervasive joint influence of epistasis and plasticity on mutational effects in Escherichia coli. Nat. Genet. 2004, 36:423-426.
-
(2004)
Nat. Genet.
, vol.36
, pp. 423-426
-
-
Remold, S.K.1
Lenski, R.E.2
-
92
-
-
78649703966
-
Rewiring of genetic networks in response to DNA damage
-
Bandyopadhyay S., et al. Rewiring of genetic networks in response to DNA damage. Science 2010, 330:1385-1389.
-
(2010)
Science
, vol.330
, pp. 1385-1389
-
-
Bandyopadhyay, S.1
-
93
-
-
33847780769
-
Plasticity of genetic interactions in metabolic networks of yeast
-
Harrison R., et al. Plasticity of genetic interactions in metabolic networks of yeast. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:2307-2312.
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 2307-2312
-
-
Harrison, R.1
-
94
-
-
78049422907
-
Gene-environment interactions at nucleotide resolution
-
Gerke J., et al. Gene-environment interactions at nucleotide resolution. PLoS Genet. 2010, 6.
-
(2010)
PLoS Genet.
, pp. 6
-
-
Gerke, J.1
-
95
-
-
79952257690
-
Epistatic interaction maps relative to multiple metabolic phenotypes
-
Snitkin E.S., Segre D. Epistatic interaction maps relative to multiple metabolic phenotypes. PLoS Genet. 2011, 7:e1001294.
-
(2011)
PLoS Genet.
, vol.7
-
-
Snitkin, E.S.1
Segre, D.2
-
96
-
-
18844430826
-
Flexibility in a gene network affecting a simple behavior in Drosophila melanogaster
-
van Swinderen B., Greenspan R.J. Flexibility in a gene network affecting a simple behavior in Drosophila melanogaster. Genetics 2005, 169:2151-2163.
-
(2005)
Genetics
, vol.169
, pp. 2151-2163
-
-
van Swinderen, B.1
Greenspan, R.J.2
-
97
-
-
55949124306
-
Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes
-
Dixon S.J., et al. Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:16653-16658.
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 16653-16658
-
-
Dixon, S.J.1
-
98
-
-
54249107599
-
Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast
-
Roguev A., et al. Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast. Science 2008, 322:405-410.
-
(2008)
Science
, vol.322
, pp. 405-410
-
-
Roguev, A.1
-
99
-
-
52949151512
-
Widespread conservation of genetic redundancy during a billion years of eukaryotic evolution
-
Vavouri T., et al. Widespread conservation of genetic redundancy during a billion years of eukaryotic evolution. Trends Genet. 2008, 24:485-488.
-
(2008)
Trends Genet.
, vol.24
, pp. 485-488
-
-
Vavouri, T.1
-
100
-
-
40149087235
-
Data and theory point to mainly additive genetic variance for complex traits
-
Hill W.G., et al. Data and theory point to mainly additive genetic variance for complex traits. PLoS Genet. 2008, 4:e1000008.
-
(2008)
PLoS Genet.
, vol.4
-
-
Hill, W.G.1
-
101
-
-
0028909487
-
Epistasis and its contribution to genetic variance components
-
Cheverud J.M., Routman E.J. Epistasis and its contribution to genetic variance components. Genetics 1995, 139:1455-1461.
-
(1995)
Genetics
, vol.139
, pp. 1455-1461
-
-
Cheverud, J.M.1
Routman, E.J.2
-
102
-
-
59149098800
-
Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis
-
de Cid R., et al. Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis. Nat. Genet. 2009, 41:211-215.
-
(2009)
Nat. Genet.
, vol.41
, pp. 211-215
-
-
de Cid, R.1
-
103
-
-
27644566200
-
+-thalassemia and the sickle cell trait
-
+-thalassemia and the sickle cell trait. Nat. Genet. 2005, 37:1253-1257.
-
(2005)
Nat. Genet.
, vol.37
, pp. 1253-1257
-
-
Williams, T.N.1
-
104
-
-
0036788576
-
Genome-wide association study and mouse model identify interaction between RET and EDNRB pathways in Hirschsprung disease
-
Carrasquillo M.M., et al. Genome-wide association study and mouse model identify interaction between RET and EDNRB pathways in Hirschsprung disease. Nat. Genet. 2002, 32:237-244.
-
(2002)
Nat. Genet.
, vol.32
, pp. 237-244
-
-
Carrasquillo, M.M.1
-
105
-
-
0036699528
-
Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS
-
Martin M.P., et al. Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS. Nat. Genet. 2002, 31:429-434.
-
(2002)
Nat. Genet.
, vol.31
, pp. 429-434
-
-
Martin, M.P.1
-
106
-
-
77949423534
-
Compensatory evolution in mitochondrial tRNAs navigates valleys of low fitness
-
Meer M.V., et al. Compensatory evolution in mitochondrial tRNAs navigates valleys of low fitness. Nature 2010, 464:279-282.
-
(2010)
Nature
, vol.464
, pp. 279-282
-
-
Meer, M.V.1
-
107
-
-
84971185409
-
The correlation between relatives on the supposition of Mendelian inheritance
-
Fisher R. The correlation between relatives on the supposition of Mendelian inheritance. Trans. R. Soc. Edinb. 1918, 52:399-433.
-
(1918)
Trans. R. Soc. Edinb.
, vol.52
, pp. 399-433
-
-
Fisher, R.1
-
108
-
-
27944476578
-
Gene function prediction from congruent synthetic lethal interactions in yeast
-
Ye P., et al. Gene function prediction from congruent synthetic lethal interactions in yeast. Mol. Syst. Biol. 2005, 1:0026.
-
(2005)
Mol. Syst. Biol.
, vol.1
, pp. 0026
-
-
Ye, P.1
-
109
-
-
57149103917
-
Finding friends and enemies in an enemies-only network: a graph diffusion kernel for predicting novel genetic interactions and co-complex membership from yeast genetic interactions
-
Qi Y., et al. Finding friends and enemies in an enemies-only network: a graph diffusion kernel for predicting novel genetic interactions and co-complex membership from yeast genetic interactions. Genome Res. 2008, 18:1991-2004.
-
(2008)
Genome Res.
, vol.18
, pp. 1991-2004
-
-
Qi, Y.1
-
110
-
-
33644864549
-
Genome-wide prediction of C. elegans genetic interactions
-
Zhong W., Sternberg P.W. Genome-wide prediction of C. elegans genetic interactions. Science 2006, 311:1481-1484.
-
(2006)
Science
, vol.311
, pp. 1481-1484
-
-
Zhong, W.1
Sternberg, P.W.2
|