Diminishing returns from beneficial mutations and pervasive epistasis shape the fitness landscape for rifampicin resistance in Pseudomonas aeruginosa

Genetics

Volumn 186, Issue 4, 2010, Pages 1345-1354

  MacLean, R C ^a   Perron, G G ^a   Gardner, A ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

RIFAMPICIN;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM ISOLATION; DRUG MEGADOSE; EVOLUTIONARY ADAPTATION; GENE INTERACTION; GENETIC EPISTASIS; GENOTYPE; MISSENSE MUTATION; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA;

BIOLOGICAL EVOLUTION; DRUG RESISTANCE, MICROBIAL; EPISTASIS, GENETIC; GENETIC FITNESS; GENOTYPE; MUTATION; PSEUDOMONAS AERUGINOSA; RIFAMPIN;

BACTERIA (MICROORGANISMS); PSEUDOMONAS AERUGINOSA;

EID: 79251553136     PISSN: 00166731     EISSN: 00166731     Source Type: Journal    
DOI: 10.1534/genetics.110.123083     Document Type: Article

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