Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugged fitness landscape

PLoS Genetics

Volumn 7, Issue 4, 2011, Pages

  Kvitek, Daniel J ^a   Sherlock, Gavin ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CONTROLLED STUDY; EPISTASIS; EVOLUTIONARY ADAPTATION; FUNGAL GENOME; FUNGAL STRAIN; FUNGUS GROWTH; FUNGUS MUTANT; GENE; GENE FREQUENCY; GENE MUTATION; GENE SEQUENCE; HXT6 GENE; HXT7 GENE; MTH1 GENE; NONHUMAN; REPRODUCTIVE FITNESS; SACCHAROMYCES CEREVISIAE; ADAPTATION; DNA SEQUENCE; GENETIC EPISTASIS; GENETIC SELECTION; GENETICS; METABOLISM; MOLECULAR EVOLUTION; STOP CODON;

SACCHAROMYCES CEREVISIAE;

GLUCOSE TRANSPORTER; HXT6 PROTEIN, S CEREVISIAE; HXT7 PROTEIN, S CEREVISIAE; MTH1 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ADAPTATION, BIOLOGICAL; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CODON, NONSENSE; EPISTASIS, GENETIC; EVOLUTION, MOLECULAR; GENE FREQUENCY; GENETIC FITNESS; GENOME, FUNGAL; MONOSACCHARIDE TRANSPORT PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SELECTION, GENETIC; SEQUENCE ANALYSIS, DNA;

EID: 79955590028     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002056     Document Type: Article

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