메뉴 건너뛰기




Volumn 3, Issue , 2007, Pages

A genome-scale metabolic reconstruction for Escherichia coli K-12 MG1655 that accounts for 1260 ORFs and thermodynamic information

Author keywords

Computational biology; Group contribution method; Systems biology; Thermodynamics

Indexed keywords

ARTICLE; BACTERIAL GENOME; BACTERIAL GROWTH; BACTERIAL METABOLISM; BIOMASS; CHEMICAL REACTION; COMPUTER MODEL; ESCHERICHIA COLI; GENE DELETION; NONHUMAN; OPEN READING FRAME; PHENOTYPE; PRIORITY JOURNAL; THERMODYNAMICS; ALGORITHM; BIOLOGICAL MODEL; BIOLOGY; COMPARATIVE STUDY; COMPUTER SIMULATION; ENERGY METABOLISM; ESCHERICHIA COLI K 12; GENETIC DATABASE; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; METHODOLOGY;

EID: 34347332311     PISSN: 17444292     EISSN: 17444292     Source Type: Journal    
DOI: 10.1038/msb4100155     Document Type: Article
Times cited : (1166)

References (66)
  • 1
    • 34347361722 scopus 로고    scopus 로고
    • (NC-IUBMB) NCotIUoBaMB (2006) Enzyme nomenclature. Moss, GP
    • (NC-IUBMB) NCotIUoBaMB (2006) Enzyme nomenclature. Moss, GP
  • 2
    • 0025276048 scopus 로고
    • Cellular concentrations of enzymes and their substrates
    • Albe KR, Butler MH, Wright BE (1990) Cellular concentrations of enzymes and their substrates. J Theor Biol 143: 163-195
    • (1990) J Theor Biol , vol.143 , pp. 163-195
    • Albe, K.R.1    Butler, M.H.2    Wright, B.E.3
  • 4
    • 0018070787 scopus 로고
    • Alternative hydroxylases for the aerobic and anaerobic biosynthesis of ubiquinone in Escherichia coli
    • Alexander K, Young IG (1978) Alternative hydroxylases for the aerobic and anaerobic biosynthesis of ubiquinone in Escherichia coli. Biochemistry 17: 4750-4755
    • (1978) Biochemistry , vol.17 , pp. 4750-4755
    • Alexander, K.1    Young, I.G.2
  • 5
    • 1542288938 scopus 로고    scopus 로고
    • Global organization of metabolic fluxes in the bacterium Escherichia coli
    • Almaas E, Kovacs B, Vicsek T, Oltvai ZN, Barabasi AL (2004) Global organization of metabolic fluxes in the bacterium Escherichia coli. Nature 427: 839-843
    • (2004) Nature , vol.427 , pp. 839-843
    • Almaas, E.1    Kovacs, B.2    Vicsek, T.3    Oltvai, Z.N.4    Barabasi, A.L.5
  • 6
    • 22844452835 scopus 로고    scopus 로고
    • Construction of lycopene-overproducing E. coli strains by combining systematic and combinatorial gene knockout targets
    • Alper H, Miyaoku K, Stephanopoulos G (2005) Construction of lycopene-overproducing E. coli strains by combining systematic and combinatorial gene knockout targets. Nat Biotechnol 23: 612-616
    • (2005) Nat Biotechnol , vol.23 , pp. 612-616
    • Alper, H.1    Miyaoku, K.2    Stephanopoulos, G.3
  • 7
    • 31544450286 scopus 로고    scopus 로고
    • Baba T, Ara T, Hasegawa M, Takai Y, Okumura Y, Baba M, Datsenko KA, Tomita M, Wanner BL, Mori H (2006) Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection. Mol Syst Biol 2: 2006.0008
    • Baba T, Ara T, Hasegawa M, Takai Y, Okumura Y, Baba M, Datsenko KA, Tomita M, Wanner BL, Mori H (2006) Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection. Mol Syst Biol 2: 2006.0008
  • 8
    • 30044433043 scopus 로고    scopus 로고
    • The global transcriptional regulatory network for metabolism in Escherichia coli attains few dominant functional states
    • Barrett CL, Herring CD, Reed JL, Palsson BO (2005) The global transcriptional regulatory network for metabolism in Escherichia coli attains few dominant functional states. Proc Natl Acad Sci USA 102: 19103-19108
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 19103-19108
    • Barrett, C.L.1    Herring, C.D.2    Reed, J.L.3    Palsson, B.O.4
  • 9
    • 0036286631 scopus 로고    scopus 로고
    • Energy balance for analysis of complex metabolic networks
    • Beard DA, Liang SD, Qian H (2002) Energy balance for analysis of complex metabolic networks. Biophys J 83: 79-86
    • (2002) Biophys J , vol.83 , pp. 79-86
    • Beard, D.A.1    Liang, S.D.2    Qian, H.3
  • 10
    • 34347258175 scopus 로고    scopus 로고
    • Quantitative prediction of cellular metabolism with constraint-based models: The COBRA toolbox
    • Becker SA, Feist AM, Mo ML, Hannum G, Palsson BO, Herrgard MJ (2007) Quantitative prediction of cellular metabolism with constraint-based models: the COBRA toolbox. Nat Protoc 2: 727-738
    • (2007) Nat Protoc , vol.2 , pp. 727-738
    • Becker, S.A.1    Feist, A.M.2    Mo, M.L.3    Hannum, G.4    Palsson, B.O.5    Herrgard, M.J.6
  • 11
    • 0027155827 scopus 로고
    • Energetic efficiency of Escherichia coli: Effects of mutations in components of the aerobic respiratory chain
    • Calhoun MW, Oden KL, Gennis RB, de Mattos MJ, Neijssel OM (1993) Energetic efficiency of Escherichia coli: effects of mutations in components of the aerobic respiratory chain. J Bacteriol 175: 3020-3025
    • (1993) J Bacteriol , vol.175 , pp. 3020-3025
    • Calhoun, M.W.1    Oden, K.L.2    Gennis, R.B.3    de Mattos, M.J.4    Neijssel, O.M.5
  • 13
    • 2342648924 scopus 로고    scopus 로고
    • Integrating high-throughput and computational data elucidates bacterial networks
    • Covert MW, Knight EM, Reed JL, Herrgard MJ, Palsson BO (2004) Integrating high-throughput and computational data elucidates bacterial networks. Nature 429: 92-96
    • (2004) Nature , vol.429 , pp. 92-96
    • Covert, M.W.1    Knight, E.M.2    Reed, J.L.3    Herrgard, M.J.4    Palsson, B.O.5
  • 14
    • 0037008673 scopus 로고    scopus 로고
    • Transcriptional regulation in constraints-based metabolic models of Escherichia coli
    • Covert MW, Palsson BO (2002) Transcriptional regulation in constraints-based metabolic models of Escherichia coli. J Biol Chem 277: 28058-28064
    • (2002) J Biol Chem , vol.277 , pp. 28058-28064
    • Covert, M.W.1    Palsson, B.O.2
  • 15
    • 0035125986 scopus 로고    scopus 로고
    • In silico predictions of Escherichia coli metabolic capabilities are consistent with experimental data
    • Edwards JS, Ibarra RU, Palsson BO (2001) In silico predictions of Escherichia coli metabolic capabilities are consistent with experimental data. Nat Biotechnol 19: 125-130
    • (2001) Nat Biotechnol , vol.19 , pp. 125-130
    • Edwards, J.S.1    Ibarra, R.U.2    Palsson, B.O.3
  • 16
    • 0034625143 scopus 로고    scopus 로고
    • The Escherichia coli MG1655 in silico metabolic genotype: Its definition, characteristics, and capabilities
    • Edwards JS, Palsson BO (2000) The Escherichia coli MG1655 in silico metabolic genotype: Its definition, characteristics, and capabilities. Proc Natl Acad Sci USA 97: 5528-5533
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 5528-5533
    • Edwards, J.S.1    Palsson, B.O.2
  • 17
    • 0038441327 scopus 로고    scopus 로고
    • Evolution experiments with microorganisms: The dynamics and genetic bases of adaptation
    • Elena SF, Lenski RE (2003) Evolution experiments with microorganisms: the dynamics and genetic bases of adaptation. Nat Rev Genet 4: 457-469
    • (2003) Nat Rev Genet , vol.4 , pp. 457-469
    • Elena, S.F.1    Lenski, R.E.2
  • 18
    • 33645462347 scopus 로고    scopus 로고
    • Feist AM, Scholten JCM, Palsson BO, Brockman FJ, Ideker T (2006) Modeling methanogenesis with a genome-scale metabolic reconstruction of Methanosarcina barkeri. Mol Syst Biol 2: 2006.0004
    • Feist AM, Scholten JCM, Palsson BO, Brockman FJ, Ideker T (2006) Modeling methanogenesis with a genome-scale metabolic reconstruction of Methanosarcina barkeri. Mol Syst Biol 2: 2006.0004
  • 19
    • 1642538406 scopus 로고    scopus 로고
    • High-throughput metabolic flux analysis based on gas chromatography-mass spectrometry derived 13C constraints
    • Fischer E, Zamboni N, Sauer U (2004) High-throughput metabolic flux analysis based on gas chromatography-mass spectrometry derived 13C constraints. Anal Biochem 325: 308-316
    • (2004) Anal Biochem , vol.325 , pp. 308-316
    • Fischer, E.1    Zamboni, N.2    Sauer, U.3
  • 21
    • 0000598585 scopus 로고    scopus 로고
    • Respiration
    • Neidhardt FC ed, pp, ASM Press: Washington, DC
    • Gennis RB, Stewart V (1996) Respiration. In Escherichia coli and Salmonella, Neidhardt FC (ed), pp 217-261. ASM Press: Washington, DC
    • (1996) Escherichia coli and Salmonella , pp. 217-261
    • Gennis, R.B.1    Stewart, V.2
  • 22
    • 27744585668 scopus 로고    scopus 로고
    • Lethality and synthetic lethality in the genome-wide metabolic network of Escherichia coli
    • Ghim CM, Goh KI, Kahng B (2005) Lethality and synthetic lethality in the genome-wide metabolic network of Escherichia coli. J Theor Biol 237: 401-411
    • (2005) J Theor Biol , vol.237 , pp. 401-411
    • Ghim, C.M.1    Goh, K.I.2    Kahng, B.3
  • 23
    • 12444299959 scopus 로고    scopus 로고
    • FieF (YiiP) from Escherichia coli mediates decreased cellular accumulation of iron and relieves iron stress
    • Grass G, Otto M, Fricke B, Haney CJ, Rensing C, Nies DH, Munkelt D (2005) FieF (YiiP) from Escherichia coli mediates decreased cellular accumulation of iron and relieves iron stress. Arch Microbiol 183: 9-18
    • (2005) Arch Microbiol , vol.183 , pp. 9-18
    • Grass, G.1    Otto, M.2    Fricke, B.3    Haney, C.J.4    Rensing, C.5    Nies, D.H.6    Munkelt, D.7
  • 24
    • 17444424937 scopus 로고    scopus 로고
    • Proton translocation coupled to formate oxidation in anaerobically grown fermenting Escherichia coli
    • Hakobyan M, Sargsyan H, Bagramyan K (2005) Proton translocation coupled to formate oxidation in anaerobically grown fermenting Escherichia coli. Biophys Chem 115: 55-61
    • (2005) Biophys Chem , vol.115 , pp. 55-61
    • Hakobyan, M.1    Sargsyan, H.2    Bagramyan, K.3
  • 25
    • 0036154795 scopus 로고    scopus 로고
    • Speed versus efficiency in microbial growth and the role of parallel pathways
    • Helling RB (2002) Speed versus efficiency in microbial growth and the role of parallel pathways. J Bacteriol 184: 1041-1045
    • (2002) J Bacteriol , vol.184 , pp. 1041-1045
    • Helling, R.B.1
  • 29
    • 0037079023 scopus 로고    scopus 로고
    • Escherichia coli K-12 undergoes adaptive evolution to achieve in silico predicted optimal growth
    • Ibarra RU, Edwards JS, Palsson BO (2002) Escherichia coli K-12 undergoes adaptive evolution to achieve in silico predicted optimal growth. Nature 420: 186-189
    • (2002) Nature , vol.420 , pp. 186-189
    • Ibarra, R.U.1    Edwards, J.S.2    Palsson, B.O.3
  • 30
    • 18744380689 scopus 로고    scopus 로고
    • Investigating metabolite essentiality through genome-scale analysis of Escherichia coli production capabilities
    • Imielinski M, Belta C, Halasz A, Rubin H (2005) Investigating metabolite essentiality through genome-scale analysis of Escherichia coli production capabilities. Bioinformatics 21: 2008-2016
    • (2005) Bioinformatics , vol.21 , pp. 2008-2016
    • Imielinski, M.1    Belta, C.2    Halasz, A.3    Rubin, H.4
  • 31
    • 20044377232 scopus 로고    scopus 로고
    • Genome coverage, literally speaking. The challenge of annotating 200 genomes with 4 million publications
    • Janssen P, Goldovsky L, Kunin V, Darzentas N, Ouzounis CA (2005) Genome coverage, literally speaking. The challenge of annotating 200 genomes with 4 million publications. EMBO Rep 6: 397-399
    • (2005) EMBO Rep , vol.6 , pp. 397-399
    • Janssen, P.1    Goldovsky, L.2    Kunin, V.3    Darzentas, N.4    Ouzounis, C.A.5
  • 32
    • 33644527950 scopus 로고    scopus 로고
    • The model organism as a system: Integrating 'omics' data sets
    • Joyce AR, Palsson BO (2006) The model organism as a system: integrating 'omics' data sets. Nat Rev Mol Cell Biol 7: 198-210
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 198-210
    • Joyce, A.R.1    Palsson, B.O.2
  • 35
    • 0033988057 scopus 로고    scopus 로고
    • Viability of an Escherichia coli pgsA null mutant lacking detectable phosphatidylglycerol and cardiolipin
    • Kikuchi S, Shibuya I, Matsumoto K (2000) Viability of an Escherichia coli pgsA null mutant lacking detectable phosphatidylglycerol and cardiolipin. J Bacteriol 182: 371-376
    • (2000) J Bacteriol , vol.182 , pp. 371-376
    • Kikuchi, S.1    Shibuya, I.2    Matsumoto, K.3
  • 36
    • 33745433792 scopus 로고    scopus 로고
    • Putative regulatory sites unraveled by network-embedded thermodynamic analysis of metabolome data
    • Kümmel A, Panke S, Heinemann M (2006a) Putative regulatory sites unraveled by network-embedded thermodynamic analysis of metabolome data. Mol Syst Biol 2: 2006.0034
    • (2006) Mol Syst Biol , vol.2 , pp. 0034
    • Kümmel, A.1    Panke, S.2    Heinemann, M.3
  • 37
    • 33845238737 scopus 로고    scopus 로고
    • Systematic assignment of thermodynamic constraints in metabolic network models
    • Kümmel A, Panke S, Heinemann M (2006b) Systematic assignment of thermodynamic constraints in metabolic network models. BMC Bioinformatics 7: 512
    • (2006) BMC Bioinformatics , vol.7 , pp. 512
    • Kümmel, A.1    Panke, S.2    Heinemann, M.3
  • 38
    • 27744478397 scopus 로고    scopus 로고
    • Systems-level analysis of genome-scale in silico metabolic models using MetaFluxNet
    • Lee SY, Woo HM, Lee D-Y, Choi HS, Kim TY, Yun H (2005) Systems-level analysis of genome-scale in silico metabolic models using MetaFluxNet. Biotechnol Bioproc Eng 10: 425-431
    • (2005) Biotechnol Bioproc Eng , vol.10 , pp. 425-431
    • Lee, S.Y.1    Woo, H.M.2    Lee, D.-Y.3    Choi, H.S.4    Kim, T.Y.5    Yun, H.6
  • 39
    • 23844444175 scopus 로고    scopus 로고
    • Lotierzo M, Tse Sum Bui B, Florentin D, Escalettes F, Marquet A (2005) Biotin synthase mechanism: an overview. Biochem Soc Transac 33: 820-823
    • Lotierzo M, Tse Sum Bui B, Florentin D, Escalettes F, Marquet A (2005) Biotin synthase mechanism: an overview. Biochem Soc Transac 33: 820-823
  • 40
    • 1642457253 scopus 로고    scopus 로고
    • The effects of alternate optimal solutions in constraint-based genome-scale metabolic models
    • Mahadevan R, Schilling CH (2003) The effects of alternate optimal solutions in constraint-based genome-scale metabolic models. Metab Eng 5: 264-276
    • (2003) Metab Eng , vol.5 , pp. 264-276
    • Mahadevan, R.1    Schilling, C.H.2
  • 41
    • 0025405421 scopus 로고
    • Simple constrained optimization view of acetate overflow in E. coli
    • Majewski RA, Domach MM (1990) Simple constrained optimization view of acetate overflow in E. coli. Biotechnol Bioeng 35: 732-738
    • (1990) Biotechnol Bioeng , vol.35 , pp. 732-738
    • Majewski, R.A.1    Domach, M.M.2
  • 42
    • 24644459850 scopus 로고    scopus 로고
    • Hydrogenase 3 but not hydrogenase 4 is major in hydrogen gas production by Escherichia coli formate hydrogenlyase at acidic pH and in the presence of external formate
    • Mnatsakanyan N, Bagramyan K, Trchounian A (2004) Hydrogenase 3 but not hydrogenase 4 is major in hydrogen gas production by Escherichia coli formate hydrogenlyase at acidic pH and in the presence of external formate. Cell Biochem Biophys 41: 357-366
    • (2004) Cell Biochem Biophys , vol.41 , pp. 357-366
    • Mnatsakanyan, N.1    Bagramyan, K.2    Trchounian, A.3
  • 44
    • 11244341009 scopus 로고    scopus 로고
    • Elucidation and structural analysis of conserved pools for genome-scale metabolic reconstructions
    • Nikolaev EV, Burgard AP, Maranas CD (2005) Elucidation and structural analysis of conserved pools for genome-scale metabolic reconstructions. Biophys J 88: 37-49
    • (2005) Biophys J , vol.88 , pp. 37-49
    • Nikolaev, E.V.1    Burgard, A.P.2    Maranas, C.D.3
  • 45
    • 13644259156 scopus 로고    scopus 로고
    • The energetic conversion competence of Escherichia coli during aerobic respiration studied by 31P NMR using a circulating fermentation system
    • Noguchi Y, Nakai Y, Shimba N, Toyosaki H, Kawahara Y, Sugimoto S, Suzuki E (2004) The energetic conversion competence of Escherichia coli during aerobic respiration studied by 31P NMR using a circulating fermentation system. J Biochem (Tokyo) 136: 509-515
    • (2004) J Biochem (Tokyo) , vol.136 , pp. 509-515
    • Noguchi, Y.1    Nakai, Y.2    Shimba, N.3    Toyosaki, H.4    Kawahara, Y.5    Sugimoto, S.6    Suzuki, E.7
  • 46
    • 28444475529 scopus 로고    scopus 로고
    • Adaptive evolution of bacterial metabolic networks by horizontal gene transfer
    • Pal C, Papp B, Lercher MJ (2005) Adaptive evolution of bacterial metabolic networks by horizontal gene transfer. Nat Genet 37: 1372-1375
    • (2005) Nat Genet , vol.37 , pp. 1372-1375
    • Pal, C.1    Papp, B.2    Lercher, M.J.3
  • 48
    • 5044230561 scopus 로고    scopus 로고
    • Two-dimensional annotation of genomes
    • Palsson BO (2004) Two-dimensional annotation of genomes. Nat Biotechnol 22: 1218-1219
    • (2004) Nat Biotechnol , vol.22 , pp. 1218-1219
    • Palsson, B.O.1
  • 49
    • 43049089438 scopus 로고
    • The maintenance energy of bacteria in growing cultures
    • Pirt SJ (1965) The maintenance energy of bacteria in growing cultures. Proc R Soc Lond B Biol Sci 163: 224-231
    • (1965) Proc R Soc Lond B Biol Sci , vol.163 , pp. 224-231
    • Pirt, S.J.1
  • 50
    • 0343035686 scopus 로고    scopus 로고
    • Stoichiometric model of Escherichia coli metabolism: Incorporation of growth-rate dependent biomass composition and mechanistic energy requirements
    • Pramanik J, Keasling JD (1997) Stoichiometric model of Escherichia coli metabolism: incorporation of growth-rate dependent biomass composition and mechanistic energy requirements. Biotechnol Bioeng 56: 398-421
    • (1997) Biotechnol Bioeng , vol.56 , pp. 398-421
    • Pramanik, J.1    Keasling, J.D.2
  • 51
    • 0032552815 scopus 로고    scopus 로고
    • Effect of Escherichia coli biomass composition on central metabolic fluxes predicted by a stoichiometric model
    • Pramanik J, Keasling JD (1998) Effect of Escherichia coli biomass composition on central metabolic fluxes predicted by a stoichiometric model. Biotechnol Bioeng 60: 230-238
    • (1998) Biotechnol Bioeng , vol.60 , pp. 230-238
    • Pramanik, J.1    Keasling, J.D.2
  • 52
    • 9544253891 scopus 로고    scopus 로고
    • Genome-scale models of microbial cells: Evaluating the consequences of constraints
    • Price ND, Reed JL, Palsson BO (2004) Genome-scale models of microbial cells: evaluating the consequences of constraints. Nat Rev Microbiol 2: 886-897
    • (2004) Nat Rev Microbiol , vol.2 , pp. 886-897
    • Price, N.D.1    Reed, J.L.2    Palsson, B.O.3
  • 53
    • 0003341153 scopus 로고    scopus 로고
    • Bacterial lipopolysaccharides: A remarkable family of bioactive macroamphiphiles
    • Neidhardt FC ed, pp, ASM Press: Washington, DC
    • Raetz CRH (1996) Bacterial lipopolysaccharides: A remarkable family of bioactive macroamphiphiles. In Escherichia coli and Salmonella, Neidhardt FC (ed), pp 1035-1063. ASM Press: Washington, DC
    • (1996) Escherichia coli and Salmonella , pp. 1035-1063
    • Raetz, C.R.H.1
  • 55
    • 0037406843 scopus 로고    scopus 로고
    • Thirteen years of building constraint-based in silico models of Escherichia coli
    • Reed JL, Palsson BO (2003) Thirteen years of building constraint-based in silico models of Escherichia coli. J Bacteriol 185: 2692-2699
    • (2003) J Bacteriol , vol.185 , pp. 2692-2699
    • Reed, J.L.1    Palsson, B.O.2
  • 57
    • 0344328817 scopus 로고    scopus 로고
    • An expanded genome-scale model of Escherichia coli K-12 (iJR904 GSM/GPR)
    • Reed JL, Vo TD, Schilling CH, Palsson BO (2003) An expanded genome-scale model of Escherichia coli K-12 (iJR904 GSM/GPR). Genome Biol 4: R54.1-R54.12
    • (2003) Genome Biol , vol.4
    • Reed, J.L.1    Vo, T.D.2    Schilling, C.H.3    Palsson, B.O.4
  • 59
    • 0030574276 scopus 로고    scopus 로고
    • Bacterial resistances to toxic metal ions - a review
    • Silver S (1996) Bacterial resistances to toxic metal ions - a review. Gene 179: 9-19
    • (1996) Gene , vol.179 , pp. 9-19
    • Silver, S.1
  • 60
    • 4644268555 scopus 로고    scopus 로고
    • Mathematical models in microbial systems biology
    • Stelling J (2004) Mathematical models in microbial systems biology. Curr Opin Microbiol 7: 513-518
    • (2004) Curr Opin Microbiol , vol.7 , pp. 513-518
    • Stelling, J.1
  • 61
    • 0017343370 scopus 로고
    • Energy conservation in chemotrophic anaerobic bacteria
    • Thauer RK, Jungermann K, Decker K (1977) Energy conservation in chemotrophic anaerobic bacteria. Bacteriol Rev 41: 100-180
    • (1977) Bacteriol Rev , vol.41 , pp. 100-180
    • Thauer, R.K.1    Jungermann, K.2    Decker, K.3
  • 62
    • 0027450492 scopus 로고
    • Structural genes for thiamine biosynthetic enzymes (thiCEFGH) in Escherichia coli K-12
    • Vander Horn PB, Backstrom AD, Stewart V, Begley TP (1993) Structural genes for thiamine biosynthetic enzymes (thiCEFGH) in Escherichia coli K-12. J Bacteriol 175: 982-992
    • (1993) J Bacteriol , vol.175 , pp. 982-992
    • Vander Horn, P.B.1    Backstrom, A.D.2    Stewart, V.3    Begley, T.P.4
  • 63
    • 0027909387 scopus 로고
    • Biochemical production capabilities of Escherichia coli
    • Varma A, Boesch BW, Palsson BO (1993) Biochemical production capabilities of Escherichia coli. Biotechnol Bioeng 42: 59-73
    • (1993) Biotechnol Bioeng , vol.42 , pp. 59-73
    • Varma, A.1    Boesch, B.W.2    Palsson, B.O.3
  • 64
    • 0027716622 scopus 로고
    • Metabolic capabilities of Escherichia coli: I. Synthesis of biosynthetic precursors and cofactors
    • Varma A, Palsson BO (1993) Metabolic capabilities of Escherichia coli: I. Synthesis of biosynthetic precursors and cofactors. J Theor Biol 165: 477-502
    • (1993) J Theor Biol , vol.165 , pp. 477-502
    • Varma, A.1    Palsson, B.O.2
  • 65
    • 0029635981 scopus 로고
    • Parametric sensitivity of stoichiometric flux balance models applied to wild-type Escherichia coli metabolism
    • Varma A, Palsson BO (1995) Parametric sensitivity of stoichiometric flux balance models applied to wild-type Escherichia coli metabolism. Biotechnol Bioeng 45: 69-79
    • (1995) Biotechnol Bioeng , vol.45 , pp. 69-79
    • Varma, A.1    Palsson, B.O.2
  • 66
    • 0016654521 scopus 로고
    • Improved chemical synthesis and enzymatic assay of delta-1-pyrroline-5-carboxylic acid
    • Williams I, Frank L (1975) Improved chemical synthesis and enzymatic assay of delta-1-pyrroline-5-carboxylic acid. Anal Biochem 64: 85-97
    • (1975) Anal Biochem , vol.64 , pp. 85-97
    • Williams, I.1    Frank, L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.