Evidence for positive epistasis in HIV-1

Science

Volumn 306, Issue 5701, 2004, Pages 1547-1550

  Bonhoeffer, Sebastian ^a   Chappey, Colombe ^b   Parkin, Neil T ^b   Whitcomb, Jeanette M ^b   Petropoulos, Christos J ^b  

^a ETH ZURICH   (Switzerland)

^b MONOGRAM BIOSCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; DATA REDUCTION; STATISTICAL METHODS; VIRUSES;

HIV; MUTATION; OFFSPRINGS; SEXUAL REPRODUCTION;

GENES;

AMINO ACID; PROTEINASE; RNA DIRECTED DNA POLYMERASE; VIRUS DNA; VIRUS RNA;

EPISTASIS; HUMAN IMMUNODEFICIENCY VIRUS;

AMINO ACID SEQUENCE; ARTICLE; CONSENSUS SEQUENCE; EPISTASIS; GENOTYPE; HUMAN IMMUNODEFICIENCY VIRUS 1; MODEL; MUTATION; NONHUMAN; PRIORITY JOURNAL; THEORY; VIRUS GENOME;

AMINO ACID SEQUENCE; AMINO ACIDS; ANTI-HIV AGENTS; DRUG RESISTANCE, VIRAL; EPISTASIS, GENETIC; EVOLUTION, MOLECULAR; GENOTYPE; HIV INFECTIONS; HIV PROTEASE; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; MUTATION; RECOMBINATION, GENETIC; SOFTWARE; VIRUS REPLICATION;

ANIMALIA; DNA VIRUSES; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 9444282038     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1101786     Document Type: Article

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30. We acknowledge the Virologic Clinical Reference laboratory for their efforts in generting the replication capacity and PR/RT sequence data and C. Althaus, V. Müller, S. Otto, T. Pfeiffer, and M. Salathé for valuable comments, S. B. acknowledges the Swiss National Science Foundation for financial support. The development of the drug resistance database and replication capacity assay used in this study was funded in part by Small Business Innovative Research-Advanced Technology Grants from the National Institute of Allergy and Infectious Diseases, NIH (R43 AI057068 and R43 AI050321). S.B. is an equity holder in Virologic, Inc.