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Volumn 42, Issue 4, 2011, Pages 317-326

Alterations of brain circuits in Down syndrome murine models

Author keywords

Mental retardation; Mouse models; Trisomy 21; Ts1Cje; Ts65Dn

Indexed keywords

NEUROTRANSMITTER;

EID: 80555131100     PISSN: 08910618     EISSN: 18736300     Source Type: Journal    
DOI: 10.1016/j.jchemneu.2011.09.002     Document Type: Review
Times cited : (20)

References (123)
  • 1
    • 34248136006 scopus 로고    scopus 로고
    • Differential effects of trisomy on brain shape and volume in related aneuploid mouse models
    • Aldridge K., Reeves R.H., Olson L.E., Richtsmeier J.T. Differential effects of trisomy on brain shape and volume in related aneuploid mouse models. Am. J. Med. Genet. A 2007, 143A:1060-1070.
    • (2007) Am. J. Med. Genet. A , vol.143 A , pp. 1060-1070
    • Aldridge, K.1    Reeves, R.H.2    Olson, L.E.3    Richtsmeier, J.T.4
  • 2
    • 77957742773 scopus 로고    scopus 로고
    • NMDA-mediated regulation of DSCAM dendritic local translation is lost in a mouse model of Down's syndrome
    • Alves-Sampaio A., Troca-Marin J.A., Montesinos M.L. NMDA-mediated regulation of DSCAM dendritic local translation is lost in a mouse model of Down's syndrome. J. Neurosci. 2010, 30:13537-13548.
    • (2010) J. Neurosci. , vol.30 , pp. 13537-13548
    • Alves-Sampaio, A.1    Troca-Marin, J.A.2    Montesinos, M.L.3
  • 4
    • 0033978891 scopus 로고    scopus 로고
    • Discovery and genetic localization of Down syndrome cerebellar phenotypes using the Ts65Dn mouse
    • Baxter L.L., Moran T.H., Richtsmeier J.T., Troncoso J., Reeves R.H. Discovery and genetic localization of Down syndrome cerebellar phenotypes using the Ts65Dn mouse. Hum. Mol. Genet. 2000, 9:195-202.
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 195-202
    • Baxter, L.L.1    Moran, T.H.2    Richtsmeier, J.T.3    Troncoso, J.4    Reeves, R.H.5
  • 5
    • 65949098892 scopus 로고    scopus 로고
    • The Down syndrome critical region is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome
    • Belichenko N.P., Belichenko P.V., Kleschevnikov A.M., Salehi A., Reeves R.H., Mobley W.C. The Down syndrome critical region is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome. J. Neurosci. 2009, 29:5938-5948.
    • (2009) J. Neurosci. , vol.29 , pp. 5938-5948
    • Belichenko, N.P.1    Belichenko, P.V.2    Kleschevnikov, A.M.3    Salehi, A.4    Reeves, R.H.5    Mobley, W.C.6
  • 6
    • 34548795562 scopus 로고    scopus 로고
    • Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships
    • Belichenko P.V., Kleschevnikov A.M., Salehi A., Epstein C.J., Mobley W.C. Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships. J. Comp. Neurol. 2007, 504:329-345.
    • (2007) J. Comp. Neurol. , vol.504 , pp. 329-345
    • Belichenko, P.V.1    Kleschevnikov, A.M.2    Salehi, A.3    Epstein, C.J.4    Mobley, W.C.5
  • 8
    • 71549157180 scopus 로고    scopus 로고
    • Lithium restores neurogenesis in the subventricular zone of the Ts65Dn mouse, a model for Down syndrome
    • Bianchi P., Ciani E., Contestabile A., Guidi S., Bartesaghi R. Lithium restores neurogenesis in the subventricular zone of the Ts65Dn mouse, a model for Down syndrome. Brain Pathol. 2010, 20:106-118.
    • (2010) Brain Pathol. , vol.20 , pp. 106-118
    • Bianchi, P.1    Ciani, E.2    Contestabile, A.3    Guidi, S.4    Bartesaghi, R.5
  • 10
    • 0037450168 scopus 로고    scopus 로고
    • Frontal cortex BDNF levels correlate with working memory in an animal model of Down syndrome
    • Bimonte-Nelson H.A., Hunter C.L., Nelson M.E., Granholm A.C. Frontal cortex BDNF levels correlate with working memory in an animal model of Down syndrome. Behav. Brain Res. 2003, 139:47-57.
    • (2003) Behav. Brain Res. , vol.139 , pp. 47-57
    • Bimonte-Nelson, H.A.1    Hunter, C.L.2    Nelson, M.E.3    Granholm, A.C.4
  • 14
    • 0037357346 scopus 로고    scopus 로고
    • Protein S100 immunoreactivity in glial cells and neurons of the Japanese quail brain
    • Castagna C., Viglietti-Panzica C., Panzica G.C. Protein S100 immunoreactivity in glial cells and neurons of the Japanese quail brain. J. Chem. Neuroanat. 2003, 25:195-212.
    • (2003) J. Chem. Neuroanat. , vol.25 , pp. 195-212
    • Castagna, C.1    Viglietti-Panzica, C.2    Panzica, G.C.3
  • 16
    • 7744237268 scopus 로고    scopus 로고
    • Functional analysis of genes implicated in Down syndrome: 1. Cognitive abilities in mice transpolygenic for Down syndrome chromosomal region-1 (DCR-1)
    • Chabert C., Jamon M., Cherfouh A., Duquenne V., Smith D.J., Rubin E., Roubertoux P.L. Functional analysis of genes implicated in Down syndrome: 1. Cognitive abilities in mice transpolygenic for Down syndrome chromosomal region-1 (DCR-1). Behav. Genet. 2004, 34:559-569.
    • (2004) Behav. Genet. , vol.34 , pp. 559-569
    • Chabert, C.1    Jamon, M.2    Cherfouh, A.3    Duquenne, V.4    Smith, D.J.5    Rubin, E.6    Roubertoux, P.L.7
  • 17
    • 33746047443 scopus 로고    scopus 로고
    • Fluoxetine rescues deficient neurogenesis in hippocampus of the Ts65Dn mouse model for Down syndrome
    • Clark S., Schwalbe J., Stasko M.R., Yarowsky P.J., Costa A.C. Fluoxetine rescues deficient neurogenesis in hippocampus of the Ts65Dn mouse model for Down syndrome. Exp. Neurol. 2006, 200:256-261.
    • (2006) Exp. Neurol. , vol.200 , pp. 256-261
    • Clark, S.1    Schwalbe, J.2    Stasko, M.R.3    Yarowsky, P.J.4    Costa, A.C.5
  • 18
    • 0027158499 scopus 로고
    • Epilepsy, dementia and adaptive behaviour in Down's syndrome
    • Collacott R.A. Epilepsy, dementia and adaptive behaviour in Down's syndrome. Intellect. Disabil. Res. 1993, 37:153-160.
    • (1993) Intellect. Disabil. Res. , vol.37 , pp. 153-160
    • Collacott, R.A.1
  • 19
    • 33645323789 scopus 로고    scopus 로고
    • Choline acetyltransferase activity at different ages in brain of Ts65Dn mice, an animal model for Down's syndrome and related neurodegenerative diseases
    • Contestabile A., Fila T., Bartesaghi R., Contestabile A., Ciani E. Choline acetyltransferase activity at different ages in brain of Ts65Dn mice, an animal model for Down's syndrome and related neurodegenerative diseases. J. Neurochem. 2006, 97:515-526.
    • (2006) J. Neurochem. , vol.97 , pp. 515-526
    • Contestabile, A.1    Fila, T.2    Bartesaghi, R.3    Contestabile, A.4    Ciani, E.5
  • 20
    • 34548102066 scopus 로고    scopus 로고
    • Cell cycle alteration and decreased cell proliferation in the hippocampal dentate gyrus and in the neocortical germinal matrix of fetuses with Down syndrome and in Ts65Dn mice
    • Contestabile A., Fila T., Ceccarelli C., Bonasoni P., Bonapace L., Santini D., Bartesaghi R., Ciani E. Cell cycle alteration and decreased cell proliferation in the hippocampal dentate gyrus and in the neocortical germinal matrix of fetuses with Down syndrome and in Ts65Dn mice. Hippocampus 2007, 17:665-678.
    • (2007) Hippocampus , vol.17 , pp. 665-678
    • Contestabile, A.1    Fila, T.2    Ceccarelli, C.3    Bonasoni, P.4    Bonapace, L.5    Santini, D.6    Bartesaghi, R.7    Ciani, E.8
  • 21
    • 77952955690 scopus 로고    scopus 로고
    • Communication breaks-Down: from neurodevelopment defects to cognitive disabilities in Down syndrome
    • Contestabile A., Benfenati F., Gasparini L. Communication breaks-Down: from neurodevelopment defects to cognitive disabilities in Down syndrome. Prog. Neurobiol. 2010, 91:1-22.
    • (2010) Prog. Neurobiol. , vol.91 , pp. 1-22
    • Contestabile, A.1    Benfenati, F.2    Gasparini, L.3
  • 24
    • 0025663975 scopus 로고
    • Segmental trisomy of murine chromosome 16: a new model system for studying Down syndrome
    • Davisson M.T., Schmidt C., Akeson E.C. Segmental trisomy of murine chromosome 16: a new model system for studying Down syndrome. Prog. Clin. Biol. Res. 1990, 360:263-280.
    • (1990) Prog. Clin. Biol. Res. , vol.360 , pp. 263-280
    • Davisson, M.T.1    Schmidt, C.2    Akeson, E.C.3
  • 26
    • 4243092575 scopus 로고    scopus 로고
    • CGMP: a second messenger for acetylcholine in the brain?
    • de Vente J. cGMP: a second messenger for acetylcholine in the brain?. Neurochem. Int. 2004, 45:799-812.
    • (2004) Neurochem. Int. , vol.45 , pp. 799-812
    • de Vente, J.1
  • 29
    • 0031890117 scopus 로고    scopus 로고
    • Impaired spatial working and reference memory in segmental trisomy (Ts65Dn) mice
    • Demas G.E., Nelson R.J., Krueger B.K., Yarowsky P.J. Impaired spatial working and reference memory in segmental trisomy (Ts65Dn) mice. Behav. Brain Res. 1998, 90:199-201.
    • (1998) Behav. Brain Res. , vol.90 , pp. 199-201
    • Demas, G.E.1    Nelson, R.J.2    Krueger, B.K.3    Yarowsky, P.J.4
  • 30
    • 0037662885 scopus 로고    scopus 로고
    • Alterations of neocortical pyramidal cell phenotype in the Ts65Dn mouse model of Down syndrome: effects of environmental enrichment
    • Dierssen M., Benavides-Piccione R., Martinez-Cue C., Estivill X., Florez J., Elston G.N., DeFelipe J. Alterations of neocortical pyramidal cell phenotype in the Ts65Dn mouse model of Down syndrome: effects of environmental enrichment. Cereb. Cortex 2003, 13:758-764.
    • (2003) Cereb. Cortex , vol.13 , pp. 758-764
    • Dierssen, M.1    Benavides-Piccione, R.2    Martinez-Cue, C.3    Estivill, X.4    Florez, J.5    Elston, G.N.6    DeFelipe, J.7
  • 33
    • 0042207862 scopus 로고
    • Observations on an ethnic classification of idiots
    • Down J.L.H. Observations on an ethnic classification of idiots. J. Mental Sci. 1867, 13:121-123.
    • (1867) J. Mental Sci. , vol.13 , pp. 121-123
    • Down, J.L.H.1
  • 34
    • 0032837516 scopus 로고    scopus 로고
    • Mild impairment of learning and memory in mice overexpressing the mSim2 gene located on chromosome 16: an animal model of Down's syndrome
    • Ema M., Ikegami S., Hosoya T., Mimura J., Ohtani H., Nakao K., Inokuchi K., Katsuki M., Fujii-Kuriyama Y. Mild impairment of learning and memory in mice overexpressing the mSim2 gene located on chromosome 16: an animal model of Down's syndrome. Hum. Mol. Genet. 1999, 8:1409-1415.
    • (1999) Hum. Mol. Genet. , vol.8 , pp. 1409-1415
    • Ema, M.1    Ikegami, S.2    Hosoya, T.3    Mimura, J.4    Ohtani, H.5    Nakao, K.6    Inokuchi, K.7    Katsuki, M.8    Fujii-Kuriyama, Y.9
  • 35
    • 0022547120 scopus 로고
    • Developmental genetics
    • Epstein C.J. Developmental genetics. Experientia 1986, 42:1117-1128.
    • (1986) Experientia , vol.42 , pp. 1117-1128
    • Epstein, C.J.1
  • 37
    • 0022271552 scopus 로고
    • Mouse trisomy 16: an animal model of human trisomy 21 (Down syndrome)
    • Epstein C.J., Cox D.R., Epstein L.B. Mouse trisomy 16: an animal model of human trisomy 21 (Down syndrome). Ann. N.Y. Acad. Sci. 1985, 450:157-168.
    • (1985) Ann. N.Y. Acad. Sci. , vol.450 , pp. 157-168
    • Epstein, C.J.1    Cox, D.R.2    Epstein, L.B.3
  • 39
    • 0031865781 scopus 로고    scopus 로고
    • Reversible impairment of long-term potentiation in transgenic Cu/Zn-SOD mice
    • Gahtan E., Auerbach J.M., Groner Y., Segal M. Reversible impairment of long-term potentiation in transgenic Cu/Zn-SOD mice. Eur. J. Neurosci. 1998, 10:538-544.
    • (1998) Eur. J. Neurosci. , vol.10 , pp. 538-544
    • Gahtan, E.1    Auerbach, J.M.2    Groner, Y.3    Segal, M.4
  • 40
    • 64549126454 scopus 로고    scopus 로고
    • Impairments in motor coordination without major changes in cerebellar plasticity in the Tc1 mouse model of Down syndrome
    • Galante M., Jani H., Vanes L., Daniel H., Fisher E.M., Tybulewicz V.L., Bliss T.V., Morice E. Impairments in motor coordination without major changes in cerebellar plasticity in the Tc1 mouse model of Down syndrome. Hum. Mol. Genet. 2009, 18:1449-1463.
    • (2009) Hum. Mol. Genet. , vol.18 , pp. 1449-1463
    • Galante, M.1    Jani, H.2    Vanes, L.3    Daniel, H.4    Fisher, E.M.5    Tybulewicz, V.L.6    Bliss, T.V.7    Morice, E.8
  • 41
    • 0035022091 scopus 로고    scopus 로고
    • On the cause of mental retardation in Down syndrome: extrapolation from full and segmental trisomy 16 mouse models
    • Galdzicki Z., Siarey R., Pearce R., Stoll J., Rapoport S.I. On the cause of mental retardation in Down syndrome: extrapolation from full and segmental trisomy 16 mouse models. Brain Res. Rev. 2001, 35:115-145.
    • (2001) Brain Res. Rev. , vol.35 , pp. 115-145
    • Galdzicki, Z.1    Siarey, R.2    Pearce, R.3    Stoll, J.4    Rapoport, S.I.5
  • 43
    • 0242348738 scopus 로고    scopus 로고
    • Mouse models of Down syndrome: how useful can they be? Comparison of the gene content of human chromosome 21 with orthologous mouse genomic regions
    • Gardiner K., Fortna A., Bechtel L., Davisson M.T. Mouse models of Down syndrome: how useful can they be? Comparison of the gene content of human chromosome 21 with orthologous mouse genomic regions. Gene 2003, 318:137-147.
    • (2003) Gene , vol.318 , pp. 137-147
    • Gardiner, K.1    Fortna, A.2    Bechtel, L.3    Davisson, M.T.4
  • 44
    • 0027186458 scopus 로고
    • Female transgenic mice carrying multiple copies of the human gene for S100 beta are hyperactive
    • Gerlai R., Friend W., Becker L., O'Hanlon D., Marks A., Roder J. Female transgenic mice carrying multiple copies of the human gene for S100 beta are hyperactive. Behav. Brain Res. 1993, 55:51-59.
    • (1993) Behav. Brain Res. , vol.55 , pp. 51-59
    • Gerlai, R.1    Friend, W.2    Becker, L.3    O'Hanlon, D.4    Marks, A.5    Roder, J.6
  • 45
    • 80555134052 scopus 로고    scopus 로고
    • Nitrinergic and Cholinergic System in the Tegmental Nuclei of a Murine Model (Ts65Dn mice) for Down Syndrome. Program No. 584.8. Neuroscience Meeting Planner. Society for Neuroscience, Washington, DC (Online).
    • Gotti, S., Caricati, E., Viglietti-Panzica, C., Panzica, G., 2005. Nitrinergic and Cholinergic System in the Tegmental Nuclei of a Murine Model (Ts65Dn mice) for Down Syndrome. Program No. 584.8. Neuroscience Meeting Planner. Society for Neuroscience, Washington, DC (Online).
    • (2005)
    • Gotti, S.1    Caricati, E.2    Viglietti-Panzica, C.3    Panzica, G.4
  • 46
    • 3242727011 scopus 로고    scopus 로고
    • Alteration of NO-producing system in the basal forebrain and hypothalamus of Ts65Dn mice: an immunohistochemical and histochemical study of a murine model for Down syndrome
    • Gotti S., Chiavegatto S., Sica M., Viglietti-Panzica C., Nelson R.J., Panzica G. Alteration of NO-producing system in the basal forebrain and hypothalamus of Ts65Dn mice: an immunohistochemical and histochemical study of a murine model for Down syndrome. Neurobiol. Dis. 2004, 16:563-571.
    • (2004) Neurobiol. Dis. , vol.16 , pp. 563-571
    • Gotti, S.1    Chiavegatto, S.2    Sica, M.3    Viglietti-Panzica, C.4    Nelson, R.J.5    Panzica, G.6
  • 47
    • 0034097607 scopus 로고    scopus 로고
    • Loss of cholinergic phenotype in basal forebrain coincides with cognitive decline in a mouse model of Down's syndrome
    • Granholm A.-C.E., Sanders L.A., Crnic L.S. Loss of cholinergic phenotype in basal forebrain coincides with cognitive decline in a mouse model of Down's syndrome. Exp. Neurol. 2000, 161:647-663.
    • (2000) Exp. Neurol. , vol.161 , pp. 647-663
    • Granholm, A.-C.E.1    Sanders, L.A.2    Crnic, L.S.3
  • 48
    • 0345874735 scopus 로고    scopus 로고
    • Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndrome
    • Granholm A.C., Sanders L., Seo H., Lin L., Ford K., Isacson O. Estrogen alters amyloid precursor protein as well as dendritic and cholinergic markers in a mouse model of Down syndrome. Hippocampus 2003, 13:905-914.
    • (2003) Hippocampus , vol.13 , pp. 905-914
    • Granholm, A.C.1    Sanders, L.2    Seo, H.3    Lin, L.4    Ford, K.5    Isacson, O.6
  • 50
    • 0029813783 scopus 로고    scopus 로고
    • Consequences of trisomy 16 for mouse brain development: corticogenesis in a model of Down syndrome
    • Haydar T.F., Blue M.E., Molliver M.E., Krueger B.K., Yarowsky P.J. Consequences of trisomy 16 for mouse brain development: corticogenesis in a model of Down syndrome. J. Neurosci. 1996, 16:6175-6182.
    • (1996) J. Neurosci. , vol.16 , pp. 6175-6182
    • Haydar, T.F.1    Blue, M.E.2    Molliver, M.E.3    Krueger, B.K.4    Yarowsky, P.J.5
  • 51
    • 0034214395 scopus 로고    scopus 로고
    • Role of founder cell deficit and delayed neuronogenesis in microencephaly of the trisomy 16 mouse
    • Haydar T.F., Nowakowski R.S., Yarowsky P.J., Krueger B.K. Role of founder cell deficit and delayed neuronogenesis in microencephaly of the trisomy 16 mouse. J. Neurosci. 2000, 20:4156-4164.
    • (2000) J. Neurosci. , vol.20 , pp. 4156-4164
    • Haydar, T.F.1    Nowakowski, R.S.2    Yarowsky, P.J.3    Krueger, B.K.4
  • 53
    • 1642268979 scopus 로고    scopus 로고
    • Functional and morphological alterations in compound transgenic mice overexpressing Cu/Zn superoxide dismutase and amyloid precursor protein
    • (correction)
    • Harris-Cerruti C., Kamsler A., Kaplan B., Lamb B., Segal M., Groner Y. Functional and morphological alterations in compound transgenic mice overexpressing Cu/Zn superoxide dismutase and amyloid precursor protein. Eur. J. Neurosci. 2004, 19:1174-1190. (correction).
    • (2004) Eur. J. Neurosci. , vol.19 , pp. 1174-1190
    • Harris-Cerruti, C.1    Kamsler, A.2    Kaplan, B.3    Lamb, B.4    Segal, M.5    Groner, Y.6
  • 59
    • 0019844319 scopus 로고
    • Unbalanced Robertsonian translocations associated with Down's syndrome or Patau's syndrome: chromosome subtype, proportion inherited, mutation rates, and sex ratio
    • Hook E.B. Unbalanced Robertsonian translocations associated with Down's syndrome or Patau's syndrome: chromosome subtype, proportion inherited, mutation rates, and sex ratio. Hum. Genet. 1981, 59:235-239.
    • (1981) Hum. Genet. , vol.59 , pp. 235-239
    • Hook, E.B.1
  • 60
    • 9144267928 scopus 로고    scopus 로고
    • Minocycline prevents cholinergic loss in a mouse model of Down's syndrome
    • Hunter C.L., Bachman D., Granholm A.C. Minocycline prevents cholinergic loss in a mouse model of Down's syndrome. Ann. Neurol. 2004, 56:675-688.
    • (2004) Ann. Neurol. , vol.56 , pp. 675-688
    • Hunter, C.L.1    Bachman, D.2    Granholm, A.C.3
  • 61
    • 3042521332 scopus 로고    scopus 로고
    • Behavioral and neurobiological markers of Alzheimer's disease in Ts65Dn mice: effects of estrogen
    • Hunter C.L., Bimonte-Nelson H.A., Nelson M., Eckman C.B., Granholm A.C. Behavioral and neurobiological markers of Alzheimer's disease in Ts65Dn mice: effects of estrogen. Neurobiol. Aging 2004, 25:873-884.
    • (2004) Neurobiol. Aging , vol.25 , pp. 873-884
    • Hunter, C.L.1    Bimonte-Nelson, H.A.2    Nelson, M.3    Eckman, C.B.4    Granholm, A.C.5
  • 65
    • 77951096438 scopus 로고    scopus 로고
    • Enlarged brain ventricles and impaired neurogenesis in the Ts1Cje and Ts2Cje mouse models of Down syndrome
    • Ishihara K., Amano K., Takaki E., Shimohata A., Sago H., Epstein C.J., Yamakawa K. Enlarged brain ventricles and impaired neurogenesis in the Ts1Cje and Ts2Cje mouse models of Down syndrome. Cereb. Cortex 2010, 20:1131-1143.
    • (2010) Cereb. Cortex , vol.20 , pp. 1131-1143
    • Ishihara, K.1    Amano, K.2    Takaki, E.3    Shimohata, A.4    Sago, H.5    Epstein, C.J.6    Yamakawa, K.7
  • 68
    • 0030271334 scopus 로고    scopus 로고
    • Characterization of sensorimotor performance, reproductive and aggressive behaviors in segmental trisomic 16 (Ts65Dn) mice
    • Klein S.L., Kriegsfeld L.J., Hairston J.E., Rau V., Nelson R.J., Yarowsky P.J. Characterization of sensorimotor performance, reproductive and aggressive behaviors in segmental trisomic 16 (Ts65Dn) mice. Physiol. Behav. 1996, 60:1159-1164.
    • (1996) Physiol. Behav. , vol.60 , pp. 1159-1164
    • Klein, S.L.1    Kriegsfeld, L.J.2    Hairston, J.E.3    Rau, V.4    Nelson, R.J.5    Yarowsky, P.J.6
  • 76
    • 71749117874 scopus 로고    scopus 로고
    • Beta-amyloid overload does not directly correlate with SAPK/JNK activation and tau protein phosphorylation in the cerebellar cortex of Ts65Dn mice
    • Lomoio S., Scherini E., Necchi D. Beta-amyloid overload does not directly correlate with SAPK/JNK activation and tau protein phosphorylation in the cerebellar cortex of Ts65Dn mice. Brain Res. 2009, 1297:198-206.
    • (2009) Brain Res. , vol.1297 , pp. 198-206
    • Lomoio, S.1    Scherini, E.2    Necchi, D.3
  • 77
    • 33746585652 scopus 로고    scopus 로고
    • Hippocampal hypocellularity in the Ts65Dn mouse originates early in development
    • Lorenzi H.A., Reeves R.H. Hippocampal hypocellularity in the Ts65Dn mouse originates early in development. Brain Res. 2006, 1104:153-159.
    • (2006) Brain Res. , vol.1104 , pp. 153-159
    • Lorenzi, H.A.1    Reeves, R.H.2
  • 79
    • 0022262488 scopus 로고
    • Changes in Alzheimer's disease in the magnocellular neurones of the supraoptic and paraventricular nuclei of the hypothalamus and their relationship to the noradrenergic deficit
    • Mann D.M., Yates P.O., Marcyniuk B. Changes in Alzheimer's disease in the magnocellular neurones of the supraoptic and paraventricular nuclei of the hypothalamus and their relationship to the noradrenergic deficit. Clin. Neuropathol. 1985, 4:127-134.
    • (1985) Clin. Neuropathol. , vol.4 , pp. 127-134
    • Mann, D.M.1    Yates, P.O.2    Marcyniuk, B.3
  • 81
    • 0030709340 scopus 로고    scopus 로고
    • Cholinergic, serotonergic and catecholaminergic neurons are not affected in Ts65Dn mice
    • Megias M., Verduga R., Dierssen M., Florez J., Insausti R., Crespo D. Cholinergic, serotonergic and catecholaminergic neurons are not affected in Ts65Dn mice. Neuroreport 1997, 8:3475-3478.
    • (1997) Neuroreport , vol.8 , pp. 3475-3478
    • Megias, M.1    Verduga, R.2    Dierssen, M.3    Florez, J.4    Insausti, R.5    Crespo, D.6
  • 83
    • 47549096987 scopus 로고    scopus 로고
    • Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome
    • Morice E., Andreae L.C., Cooke S.F., Vanes L., Fisher E.M., Tybulewicz V.L., Bliss T.V. Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome. Learn. Mem. 2008, 15:492-500.
    • (2008) Learn. Mem. , vol.15 , pp. 492-500
    • Morice, E.1    Andreae, L.C.2    Cooke, S.F.3    Vanes, L.4    Fisher, E.M.5    Tybulewicz, V.L.6    Bliss, T.V.7
  • 85
    • 0000432897 scopus 로고
    • Neural and cognitive development in Down syndrome
    • Wiley-Liss, New York, L. Nadel, D. Rosenthal (Eds.)
    • Nadel L. Neural and cognitive development in Down syndrome. Down Syndrome: Living and Learning in the Community 1994, 107-114. Wiley-Liss, New York. L. Nadel, D. Rosenthal (Eds.).
    • (1994) Down Syndrome: Living and Learning in the Community , pp. 107-114
    • Nadel, L.1
  • 86
    • 55349091989 scopus 로고    scopus 로고
    • Axonal abnormalities in cerebellar Purkinje cells of the Ts65Dn mouse
    • Necchi D., Lomoio S., Scherini E. Axonal abnormalities in cerebellar Purkinje cells of the Ts65Dn mouse. Brain Res. 2008, 1238:181-188.
    • (2008) Brain Res. , vol.1238 , pp. 181-188
    • Necchi, D.1    Lomoio, S.2    Scherini, E.3
  • 90
    • 3042612213 scopus 로고    scopus 로고
    • Down syndrome mouse models Ts65Dn, Ts1Cje, and Ms1Cje/Ts65Dn exhibit variable severity of cerebellar phenotypes
    • Olson L.E., Roper R.J., Baxter L.L., Carlson E.J., Epstein C.J., Reeves R.H. Down syndrome mouse models Ts65Dn, Ts1Cje, and Ms1Cje/Ts65Dn exhibit variable severity of cerebellar phenotypes. Dev. Dyn. 2004, 230:581-589.
    • (2004) Dev. Dyn. , vol.230 , pp. 581-589
    • Olson, L.E.1    Roper, R.J.2    Baxter, L.L.3    Carlson, E.J.4    Epstein, C.J.5    Reeves, R.H.6
  • 92
    • 0030759087 scopus 로고    scopus 로고
    • Anatomically specific colocalization of NADPH-diaphorase and choline acetyltransferase in the quail brainstem
    • Panzica G.C., Garzino A. Anatomically specific colocalization of NADPH-diaphorase and choline acetyltransferase in the quail brainstem. Neurosci. Lett. 1997, 231:151-154.
    • (1997) Neurosci. Lett. , vol.231 , pp. 151-154
    • Panzica, G.C.1    Garzino, A.2
  • 93
    • 80555146018 scopus 로고    scopus 로고
    • Vasopressinergic system and aging in the female Ts65Dn mouse, a murine model for Down syndrome
    • Panzica G.C., Bassi L., Gotti S. Vasopressinergic system and aging in the female Ts65Dn mouse, a murine model for Down syndrome. Front. Neuroendocrinol. 2006, 27:2.
    • (2006) Front. Neuroendocrinol. , vol.27 , pp. 2
    • Panzica, G.C.1    Bassi, L.2    Gotti, S.3
  • 94
    • 0023394137 scopus 로고
    • The causes of Down syndrome
    • 60
    • Patterson D. The causes of Down syndrome. Sci. Am. 1987, 257:52-57. 60.
    • (1987) Sci. Am. , vol.257 , pp. 52-57
    • Patterson, D.1
  • 95
    • 13144260659 scopus 로고    scopus 로고
    • Down syndrome and genetics - a case of linked histories
    • Patterson D., Costa A.C. Down syndrome and genetics - a case of linked histories. Nat. Rev. Genet. 2005, 6:137-147.
    • (2005) Nat. Rev. Genet. , vol.6 , pp. 137-147
    • Patterson, D.1    Costa, A.C.2
  • 97
  • 98
    • 51249103592 scopus 로고    scopus 로고
    • Abnormal expression of synaptic proteins and neurotrophin-3 in the Down syndrome mouse model Ts65Dn
    • Pollonini G., Gao V., Rabe A., Palminiello S., Albertini G., Alberini C.M. Abnormal expression of synaptic proteins and neurotrophin-3 in the Down syndrome mouse model Ts65Dn. Neuroscience 2008, 156:99-106.
    • (2008) Neuroscience , vol.156 , pp. 99-106
    • Pollonini, G.1    Gao, V.2    Rabe, A.3    Palminiello, S.4    Albertini, G.5    Alberini, C.M.6
  • 99
    • 67349127561 scopus 로고    scopus 로고
    • Upregulation of beta-catenin expression in Down syndrome model Ts65Dn mouse brain
    • Ramakrishna N., Meeker H.C., Li S., Brown W.T., Rao R., El Idrissi A. Upregulation of beta-catenin expression in Down syndrome model Ts65Dn mouse brain. Neuroscience 2009, 161:451-458.
    • (2009) Neuroscience , vol.161 , pp. 451-458
    • Ramakrishna, N.1    Meeker, H.C.2    Li, S.3    Brown, W.T.4    Rao, R.5    El Idrissi, A.6
  • 102
    • 0029067151 scopus 로고
    • S100 protein expression in subpopulations of neurons of rat brain
    • Rickmann M., Wolff J.R. S100 protein expression in subpopulations of neurons of rat brain. Neuroscience 1995, 67:977-991.
    • (1995) Neuroscience , vol.67 , pp. 977-991
    • Rickmann, M.1    Wolff, J.R.2
  • 103
    • 0037433652 scopus 로고    scopus 로고
    • Down's syndrome
    • Roizen N.J., Patterson D. Down's syndrome. Lancet 2003, 361:1281-1289.
    • (2003) Lancet , vol.361 , pp. 1281-1289
    • Roizen, N.J.1    Patterson, D.2
  • 105
    • 78049400024 scopus 로고    scopus 로고
    • Mouse models of cognitive disabilities in trisomy 21 (Down syndrome)
    • Roubertoux P.L., Carlier M. Mouse models of cognitive disabilities in trisomy 21 (Down syndrome). Am. J. Med. Genet. C: Semin. Med. Genet. 2010, 154C:400-416.
    • (2010) Am. J. Med. Genet. C: Semin. Med. Genet. , vol.154 C , pp. 400-416
    • Roubertoux, P.L.1    Carlier, M.2
  • 106
    • 33745024585 scopus 로고    scopus 로고
    • Trisomy 21: from chromosomes to mental retardation
    • Roubertoux P.L., Kerdelhue B. Trisomy 21: from chromosomes to mental retardation. Behav. Genet. 2006, 36:346-354.
    • (2006) Behav. Genet. , vol.36 , pp. 346-354
    • Roubertoux, P.L.1    Kerdelhue, B.2
  • 107
    • 18044369095 scopus 로고    scopus 로고
    • Cell proliferation is reduced in the dentate gyrus of aged but not young Ts65Dn mice, a model of Down syndrome
    • Rueda N., Mostany R., Pazos A., Florez J., Martinez-Cue C. Cell proliferation is reduced in the dentate gyrus of aged but not young Ts65Dn mice, a model of Down syndrome. Neurosci. Lett. 2005, 380:197-201.
    • (2005) Neurosci. Lett. , vol.380 , pp. 197-201
    • Rueda, N.1    Mostany, R.2    Pazos, A.3    Florez, J.4    Martinez-Cue, C.5
  • 109
    • 0033756144 scopus 로고    scopus 로고
    • Genetic dissection of region associated with behavioral abnormalities in mouse models for Down syndrome
    • Sago H., Carlson E.J., Smith D.J., Rubin E.M., Crnic L.S., Huang T.T., Epstein C.J. Genetic dissection of region associated with behavioral abnormalities in mouse models for Down syndrome. Pediatr. Res. 2000, 48:606-613.
    • (2000) Pediatr. Res. , vol.48 , pp. 606-613
    • Sago, H.1    Carlson, E.J.2    Smith, D.J.3    Rubin, E.M.4    Crnic, L.S.5    Huang, T.T.6    Epstein, C.J.7
  • 111
    • 0042420452 scopus 로고    scopus 로고
    • Global disruption of the cerebellar transcriptome in a Down syndrome mouse model
    • Saran N.G., Pletcher M.T., Natale J.E., Cheng Y., Reeves R.H. Global disruption of the cerebellar transcriptome in a Down syndrome mouse model. Hum. Mol. Genet. 2003, 12:2013-2019.
    • (2003) Hum. Mol. Genet. , vol.12 , pp. 2013-2019
    • Saran, N.G.1    Pletcher, M.T.2    Natale, J.E.3    Cheng, Y.4    Reeves, R.H.5
  • 113
    • 18244388693 scopus 로고    scopus 로고
    • Abnormal APP, cholinergic and cognitive function in Ts65Dn Down's model mice
    • Seo H., Isacson O. Abnormal APP, cholinergic and cognitive function in Ts65Dn Down's model mice. Exp. Neurol. 2005, 193:469-480.
    • (2005) Exp. Neurol. , vol.193 , pp. 469-480
    • Seo, H.1    Isacson, O.2
  • 118
    • 0032729863 scopus 로고    scopus 로고
    • Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome
    • Siarey R.J., Carlson E.J., Epstein C.J., Balbo A., Rapoport S.I., Galdzicki Z. Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome. Neuropharmacology 1999, 38:1917-1920.
    • (1999) Neuropharmacology , vol.38 , pp. 1917-1920
    • Siarey, R.J.1    Carlson, E.J.2    Epstein, C.J.3    Balbo, A.4    Rapoport, S.I.5    Galdzicki, Z.6
  • 119
    • 0029075809 scopus 로고
    • Construction of a panel of transgenic mice containing a contiguous 2-Mb set of YAC/P1 clones from human chromosome 21q22.2
    • Smith D.J., Zhu Y., Zhang J., Cheng J.F., Rubin E.M. Construction of a panel of transgenic mice containing a contiguous 2-Mb set of YAC/P1 clones from human chromosome 21q22.2. Genomics 1995, 27:425-434.
    • (1995) Genomics , vol.27 , pp. 425-434
    • Smith, D.J.1    Zhu, Y.2    Zhang, J.3    Cheng, J.F.4    Rubin, E.M.5
  • 120
    • 33745028432 scopus 로고    scopus 로고
    • Neuroanatomy of Down syndrome in vivo: a model of preclinical Alzheimer's disease
    • Teipel S.J., Hampel H. Neuroanatomy of Down syndrome in vivo: a model of preclinical Alzheimer's disease. Behav. Genet. 2006, 36:405-415.
    • (2006) Behav. Genet. , vol.36 , pp. 405-415
    • Teipel, S.J.1    Hampel, H.2
  • 121
    • 18944397794 scopus 로고    scopus 로고
    • Identification and characterization of a new Down syndrome model, Ts[Rb(12.1716)]2Cje, resulting from a spontaneous Robertsonian fusion between T(171)65Dn and mouse chromosome 12
    • Villar A.J., Belichenko P.V., Gillespie A.M., Kozy H.M., Mobley W.C., Epstein C.J. Identification and characterization of a new Down syndrome model, Ts[Rb(12.1716)]2Cje, resulting from a spontaneous Robertsonian fusion between T(171)65Dn and mouse chromosome 12. Mamm. Genome 2005, 16:79-90.
    • (2005) Mamm. Genome , vol.16 , pp. 79-90
    • Villar, A.J.1    Belichenko, P.V.2    Gillespie, A.M.3    Kozy, H.M.4    Mobley, W.C.5    Epstein, C.J.6
  • 122
    • 0021049766 scopus 로고
    • Catecholamines and cholinergic enzymes in pre-senile and senile Alzheimer-type dementia and Down's syndrome
    • Yates C.M., Simpson J., Gordon A., Maloney A.F., Allison Y., Ritchie I.M., Urquhart A. Catecholamines and cholinergic enzymes in pre-senile and senile Alzheimer-type dementia and Down's syndrome. Brain Res. 1983, 280:119-126.
    • (1983) Brain Res. , vol.280 , pp. 119-126
    • Yates, C.M.1    Simpson, J.2    Gordon, A.3    Maloney, A.F.4    Allison, Y.5    Ritchie, I.M.6    Urquhart, A.7


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