-
1
-
-
0037433652
-
Down's syndrome
-
Roizen, N. J. & Patterson, D. Down's syndrome. Lancet 361, 1281-1289 (2003).
-
(2003)
Lancet
, vol.361
, pp. 1281-1289
-
-
Roizen, N.J.1
Patterson, D.2
-
2
-
-
0002931375
-
Le mongolism: Premier exemple d'aberration autosomique humaine
-
in French
-
Lejeune, J. Le mongolism: premier exemple d'aberration autosomique humaine. Ann. Genet. 1, 41-49 (1959) (in French).
-
(1959)
Ann. Genet.
, vol.1
, pp. 41-49
-
-
Lejeune, J.1
-
3
-
-
0035827573
-
Racial disparities in median age at death of persons with Down syndrome - United States, 1968-1997
-
Friedman, J. M. Racial disparities in median age at death of persons with Down syndrome - United States, 1968-1997. MMWR Morb. Mortal Weekly Rep. 50, 463-465 (2001).
-
(2001)
MMWR Morb. Mortal Weekly Rep.
, vol.50
, pp. 463-465
-
-
Friedman, J.M.1
-
4
-
-
1842483988
-
Clinical, social, and ethical implications of changing life expectancy in Down syndrome
-
Bittles, A. H. & Glasson, E. J. Clinical, Social, and ethical implications of changing life expectancy in Down syndrome. Dev. Med. Child Neurol. 46, 282-285 (2004).
-
(2004)
Dev. Med. Child Neurol.
, vol.46
, pp. 282-285
-
-
Bittles, A.H.1
Glasson, E.J.2
-
5
-
-
13144294623
-
-
(eds Hassold, T. J. & Patterson, D.) (Wiley-Liss, New York)
-
Cohen, W. I. in Down Syndrome: a Promising Future Together (eds Hassold, T. J. & Patterson, D.) 15-36 (Wiley-Liss, New York, 1999).
-
(1999)
Down Syndrome: A Promising Future Together
, pp. 15-36
-
-
Cohen, W.I.1
-
9
-
-
0002781574
-
Versuche über pflanzen-hybriden
-
(in German); English translation available online
-
Mendel, G. Versuche über Pflanzen-Hybriden. Verhand. naturfors. Vereines in Brunn 4, 3-47 (1865) (in German); English translation available online at 〈http://www. mendelweb.org/Mendel.html〉.
-
(1865)
Verhand. Naturfors. Vereines in Brunn
, vol.4
, pp. 3-47
-
-
Mendel, G.1
-
10
-
-
0000922691
-
Observations on an ethnic classification of idiots
-
Down, J. L. H. Observations on an ethnic classification of idiots. Lond. Hosp. Rep. 3, 259-262 (1866); reprinted in Ment. Retard. 33, 54-56 (1995).
-
(1866)
Lond. Hosp. Rep.
, vol.3
, pp. 259-262
-
-
Down, J.L.H.1
-
11
-
-
13144262074
-
-
reprinted
-
Down, J. L. H. Observations on an ethnic classification of idiots. Lond. Hosp. Rep. 3, 259-262 (1866); reprinted in Ment. Retard. 33, 54-56 (1995).
-
(1995)
Ment. Retard.
, vol.33
, pp. 54-56
-
-
-
13
-
-
0001105689
-
Mongolian imbecility
-
Shuttleworth, G. E. Mongolian imbecility. BMJ 2, 661-665 (1909).
-
(1909)
BMJ
, vol.2
, pp. 661-665
-
-
Shuttleworth, G.E.1
-
15
-
-
0028856460
-
An english translation of Alzheimer's 1907 paper, "über eine eigenartige erkankung der hirnrinde"
-
Alzheimer, A., Stelzmann, R. A., Schnitzlein, H. N. & Murtagh, F. R. An English translation of Alzheimer's 1907 paper, "Über eine eigenartige Erkankung der Hirnrinde". Clin Anat. 8, 429-431 (1995).
-
(1995)
Clin Anat.
, vol.8
, pp. 429-431
-
-
Alzheimer, A.1
Stelzmann, R.A.2
Schnitzlein, H.N.3
Murtagh, F.R.4
-
16
-
-
0001147805
-
Early senile dementia in mongoloid idiocy
-
Jervis, G. A. Early senile dementia in mongoloid idiocy. Am. J. Psychiatry 105, 102-106 (1948).
-
(1948)
Am. J. Psychiatry
, vol.105
, pp. 102-106
-
-
Jervis, G.A.1
-
17
-
-
0006550774
-
Mongolism
-
Allen, G. et al. "Mongolism". Lancet 1, 775 (1961).
-
(1961)
Lancet
, vol.1
, pp. 775
-
-
Allen, G.1
-
18
-
-
0018412069
-
On the diagnostic term "Down's disease"
-
Howard-Jones, N. On the diagnostic term "Down's disease". Med. Hist. 23, 102-104 (1979).
-
(1979)
Med. Hist.
, vol.23
, pp. 102-104
-
-
Howard-Jones, N.1
-
19
-
-
84951611381
-
Beitrage zur kenntnis der zelle und ihrer lebenserscheinungen, thiel II
-
in German
-
Flemming, W. Beitrage zur kenntnis der zelle und ihrer Lebenserscheinungen, Thiel II. Archiv. Mikroskopische Anatomie 18, 151-259 (1880) (in German); English translation available in J. Cell Biol. 25, 3-69 (1965).
-
(1880)
Archiv. Mikroskopische Anatomie
, vol.18
, pp. 151-259
-
-
Flemming, W.1
-
20
-
-
84951611381
-
-
English translation available
-
Flemming, W. Beitrage zur kenntnis der zelle und ihrer Lebenserscheinungen, Thiel II. Archiv. Mikroskopische Anatomie 18, 151-259 (1880) (in German); English translation available in J. Cell Biol. 25, 3-69 (1965).
-
(1965)
J. Cell Biol.
, vol.25
, pp. 3-69
-
-
-
21
-
-
0000451146
-
The chromosomes in heredity
-
Sutton, W. S. The chromosomes in heredity. Biol. Bull. 4, 231-251 (1903).
-
(1903)
Biol. Bull.
, vol.4
, pp. 231-251
-
-
Sutton, W.S.1
-
22
-
-
0004069985
-
-
Constable Press, London
-
Morgan, T. H., Sturtevant, A. H., Muller, H. J. & Bridges, C. B. The Mechanism of Mendelian Heredity (Constable Press, London, 1915).
-
(1915)
The Mechanism of Mendelian Heredity
-
-
Morgan, T.H.1
Sturtevant, A.H.2
Muller, H.J.3
Bridges, C.B.4
-
23
-
-
0037603960
-
The Y-chromosome in mammals
-
Painter, T. The Y-chromosome in mammals. Science 53, 503-504 (1921).
-
(1921)
Science
, vol.53
, pp. 503-504
-
-
Painter, T.1
-
24
-
-
0001302511
-
Studies in mammalian spermatogenesis. II. The spermatogenesis of man
-
Painter, T. Studies in mammalian spermatogenesis. II. The spermatogenesis of man. J. Exp. Zool. 37, 291-336 (1923).
-
(1923)
J. Exp. Zool.
, vol.37
, pp. 291-336
-
-
Painter, T.1
-
25
-
-
0344953558
-
-
(ed. Jones, D. F.) (Brooklyn Botanic Garden, New York)
-
Davenport, C. B. in Sixth International Congress of Genetics Vol. 1. (ed. Jones, D. F.) 135-140 (Brooklyn Botanic Garden, New York, 1932).
-
(1932)
Sixth International Congress of Genetics
, vol.1
, pp. 135-140
-
-
Davenport, C.B.1
-
27
-
-
84981834288
-
The chromosome number of man
-
Tjio, J. H. & Levan, A. The chromosome number of man. Hereditas 42, 1-6 (1956).
-
(1956)
Hereditas
, vol.42
, pp. 1-6
-
-
Tjio, J.H.1
Levan, A.2
-
28
-
-
13144306674
-
Three chromosome numbers in whites and Japanese
-
Kodani, M. Three chromosome numbers in whites and Japanese. Science 127, 1339-1340 (1958).
-
(1958)
Science
, vol.127
, pp. 1339-1340
-
-
Kodani, M.1
-
29
-
-
0345381427
-
Genetics of somatic mammalian cells. II. Chromosomal constitution of cells in tissue culture
-
Tjio, J. H. & Puck, T. T. Genetics of somatic mammalian cells. II. Chromosomal constitution of cells in tissue culture. J. Exp. Med. 108, 259-268 (1958).
-
(1958)
J. Exp. Med.
, vol.108
, pp. 259-268
-
-
Tjio, J.H.1
Puck, T.T.2
-
30
-
-
84953420724
-
The somatic chromosomes in mongolism
-
Jacobs, P. A., Baikie, A. G. Court-Brown, W. M. & Strong, J. A. The somatic chromosomes in mongolism. Lancet 1, 710 (1959).
-
(1959)
Lancet
, vol.1
, pp. 710
-
-
Jacobs, P.A.1
Baikie, A.G.2
Court-Brown, W.M.3
Strong, J.A.4
-
31
-
-
0001247686
-
A mongol girl with 46 chromosomes
-
Polani, P. E. et al. A mongol girl with 46 chromosomes. Lancet 1, 313-324 (1960).
-
(1960)
Lancet
, vol.1
, pp. 313-324
-
-
Polani, P.E.1
-
32
-
-
0006498260
-
Chromosome translocation as a cause of familial mongolism
-
Carter, C. O., Hamerton, J. L., Polani, P. E., Gunalp, E. & Weller, S. D. Chromosome translocation as a cause of familial mongolism. Lancet 2, 678-680 (1960).
-
(1960)
Lancet
, vol.2
, pp. 678-680
-
-
Carter, C.O.1
Hamerton, J.L.2
Polani, P.E.3
Gunalp, E.4
Weller, S.D.5
-
33
-
-
0013582480
-
21-Trisomy/normal mosaicism in an intelligent child with some Mongoloid characters
-
Clarke, C. M., Edwards, J. H. & Smallpiece, V. 21-trisomy/normal mosaicism in an intelligent child with some Mongoloid characters. Lancet 18, 1028-1030 (1961).
-
(1961)
Lancet
, vol.18
, pp. 1028-1030
-
-
Clarke, C.M.1
Edwards, J.H.2
Smallpiece, V.3
-
34
-
-
0014723281
-
Identification of human chromosomes by DNA-binding fluorescent agents
-
Caspersson, T., Zech, L., Johansson, C. & Modest, E. J. Identification of human chromosomes by DNA-binding fluorescent agents. Chromosoma 30, 215-227 (1970).
-
(1970)
Chromosoma
, vol.30
, pp. 215-227
-
-
Caspersson, T.1
Zech, L.2
Johansson, C.3
Modest, E.J.4
-
35
-
-
0014878537
-
Distinction between extra G-like chromosomes by quinacrine mustard fluorescence analysis
-
Caspersson, T., Hultén, M., Lindsten, J. & Zech, L. Distinction between extra G-like chromosomes by quinacrine mustard fluorescence analysis. Exp. Cell Res. 63, 240-243 (1970).
-
(1970)
Exp. Cell Res.
, vol.63
, pp. 240-243
-
-
Caspersson, T.1
Hultén, M.2
Lindsten, J.3
Zech, L.4
-
36
-
-
0015794093
-
Partial trisomy 21
-
Aula, P., Leisti, J. & von Koskull, H. Partial trisomy 21. Clin. Genet. 4, 241-251 (1973).
-
(1973)
Clin. Genet.
, vol.4
, pp. 241-251
-
-
Aula, P.1
Leisti, J.2
Von Koskull, H.3
-
37
-
-
0015951321
-
Down's syndrome: The possibility of a pathogenetic segment on chromosome no. 21
-
Niebuhr, E. Down's syndrome: the possibility of a pathogenetic segment on chromosome no. 21. Humangenetik 21, 99-101 (1974).
-
(1974)
Humangenetik
, vol.21
, pp. 99-101
-
-
Niebuhr, E.1
-
38
-
-
0025170497
-
Molecular definition of a region of chromosome 21 that causes features of the Down syndrome phenotype
-
Korenberg, J. R. et al. Molecular definition of a region of chromosome 21 that causes features of the Down syndrome phenotype. Am. J. Hum. Genet. 47, 236-246 (1990).
-
(1990)
Am. J. Hum. Genet.
, vol.47
, pp. 236-246
-
-
Korenberg, J.R.1
-
39
-
-
0027874350
-
Molecular mapping of twenty-four features of Down syndrome on chromosome 21
-
Delabar, J.-M. et al. Molecular mapping of twenty-four features of Down syndrome on chromosome 21. Eur. J. Hum. Genet. 1, 114-124 (1993).
-
(1993)
Eur. J. Hum. Genet.
, vol.1
, pp. 114-124
-
-
Delabar, J.-M.1
-
40
-
-
0028341315
-
Down syndrome phenotypes: The consequences of chromosomal imbalance
-
Korenberg, J. R. et al. Down syndrome phenotypes: the consequences of chromosomal imbalance. Proc. Natl Acad. Sci. USA 91, 4997-5001 (1994).
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 4997-5001
-
-
Korenberg, J.R.1
-
41
-
-
18544383778
-
Down syndrome congenital heart disease: A narrowed region and a candidate gene
-
Barlow, G. M. et al. Down syndrome congenital heart disease: a narrowed region and a candidate gene. Genet. Med. 3, 91-101 (2001).
-
(2001)
Genet. Med.
, vol.3
, pp. 91-101
-
-
Barlow, G.M.1
-
42
-
-
0020661091
-
Down syndrome - A disruption of homeostasis
-
Shapiro, B. L. Down syndrome - a disruption of homeostasis. Am. J. Med. Genet. 14, 241-269 (1983).
-
(1983)
Am. J. Med. Genet.
, vol.14
, pp. 241-269
-
-
Shapiro, B.L.1
-
43
-
-
0032585844
-
The 'gene dosage effect' hypothesis versus the 'amplified developmental instability' hypothesis in Down syndrome
-
Pritchard, M. A. & Kola, I. The 'gene dosage effect' hypothesis versus the 'amplified developmental instability' hypothesis in Down syndrome. J. Neural Transm. 57, 293-303 (1999).
-
(1999)
J. Neural Transm.
, vol.57
, pp. 293-303
-
-
Pritchard, M.A.1
Kola, I.2
-
44
-
-
0023103748
-
The genetic defect causing familial Alzheimer's disease maps on chromosome 21
-
St George-Hyslop, P. H. et al. The genetic defect causing familial Alzheimer's disease maps on chromosome 21. Science 235, 885-890 (1997).
-
(1997)
Science
, vol.235
, pp. 885-890
-
-
St. George-Hyslop, P.H.1
-
45
-
-
0026088977
-
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
-
Goate, A. et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature 349, 704-706 (1991).
-
(1991)
Nature
, vol.349
, pp. 704-706
-
-
Goate, A.1
-
46
-
-
0035412104
-
Pattern of malignant disorders in individuals with Down's syndrome
-
Hasle, H. Pattern of malignant disorders in individuals with Down's syndrome. Lancet Oncol. 2, 429-436 (2001).
-
(2001)
Lancet Oncol.
, vol.2
, pp. 429-436
-
-
Hasle, H.1
-
47
-
-
0028926083
-
Clinical and molecular studies in full trisomy 22: Further delineation of the phenotype and review of the literature
-
Bacino, C. A. et al. Clinical and molecular studies in full trisomy 22: further delineation of the phenotype and review of the literature. Am. J. Med. Genet. 56, 359-365 (1995).
-
(1995)
Am. J. Med. Genet.
, vol.56
, pp. 359-365
-
-
Bacino, C.A.1
-
48
-
-
0015582421
-
The linkage of genes for the human interferon-induced antiviral protein and indophenol oxidase-B traits to chromosome G- 21
-
Tan, Y. H., Tischfield, J. & Ruddle, F. H. The linkage of genes for the human interferon-induced antiviral protein and indophenol oxidase-B traits to chromosome G-21. J. Exp. Med. 137, 317-330 (1973).
-
(1973)
J. Exp. Med.
, vol.137
, pp. 317-330
-
-
Tan, Y.H.1
Tischfield, J.2
Ruddle, F.H.3
-
49
-
-
0017645849
-
Synteny between glycinamide ribonucleotide synthetase and superoxide dismutase (soluble)
-
Moore, E. M., Jones, C., Kao, F.-T. & Oates, D. C. Synteny between glycinamide ribonucleotide synthetase and superoxide dismutase (soluble). Am. J. Hum. Genet. 29, 389-396 (1977).
-
(1977)
Am. J. Hum. Genet.
, vol.29
, pp. 389-396
-
-
Moore, E.M.1
Jones, C.2
Kao, F.-T.3
Oates, D.C.4
-
50
-
-
0025697382
-
Report of the committee on the genetic constitution of chromosome 21
-
Cox, D. R. & Shimizu, N. Report of the committee on the genetic constitution of chromosome 21. Cytogenet. Cell Genet. 55, 235-244 (1990).
-
(1990)
Cytogenet. Cell Genet.
, vol.55
, pp. 235-244
-
-
Cox, D.R.1
Shimizu, N.2
-
51
-
-
0029555402
-
Molecular analysis and breakpoint definition of a set of human chromosome 21 somatic cell hybrids
-
Graw, S. L. et al. Molecular analysis and breakpoint definition of a set of human chromosome 21 somatic cell hybrids. Somat. Cell Mol. Genet. 21, 415-428 (1995).
-
(1995)
Somat. Cell Mol. Genet.
, vol.21
, pp. 415-428
-
-
Graw, S.L.1
-
52
-
-
0029551063
-
YAC analysis and minimal tiling path construction for chromosome 21q
-
Gardiner, K. et al. YAC analysis and minimal tiling path construction for chromosome 21q. Somat. Cell Mol. Genet. 21, 399-414 (1995).
-
(1995)
Somat. Cell Mol. Genet.
, vol.21
, pp. 399-414
-
-
Gardiner, K.1
-
53
-
-
0016862453
-
New method for mapping genes in human chromosomes
-
Goss S. J. & Harris H. New method for mapping genes in human chromosomes. Nature 255, 680-684 (1975).
-
(1975)
Nature
, vol.255
, pp. 680-684
-
-
Goss, S.J.1
Harris, H.2
-
54
-
-
0025131820
-
Radiation hybrid mapping: A somatic cell genetic method for constructing high-resolution maps of mammalian chromosomes
-
Cox, D. R., Burmeister, M., Price, E. R., Kim, S. & Myers, R. M. Radiation hybrid mapping: a somatic cell genetic method for constructing high-resolution maps of mammalian chromosomes. Science 259, 245-250 (1990).
-
(1990)
Science
, vol.259
, pp. 245-250
-
-
Cox, D.R.1
Burmeister, M.2
Price, E.R.3
Kim, S.4
Myers, R.M.5
-
55
-
-
0033804332
-
Patterns of meiotic recombination on the long arm of human chromosome 21
-
Lynn, A. et al. Patterns of meiotic recombination on the long arm of human chromosome 21. Genome Res. 10, 1319-1332 (2000).
-
(2000)
Genome Res.
, vol.10
, pp. 1319-1332
-
-
Lynn, A.1
-
56
-
-
0034001512
-
Down syndrome: Genetic recombination and the origin of the extra chromosome 21
-
Hassold, T. & Sherman, S. Down syndrome: genetic recombination and the origin of the extra chromosome 21. Clin. Genet. 57, 95-100 (2000).
-
(2000)
Clin. Genet.
, vol.57
, pp. 95-100
-
-
Hassold, T.1
Sherman, S.2
-
57
-
-
0035865257
-
Integration of cytogenetic landmarks into the draft sequence of the human genome
-
Cheung, V. G. et al. Integration of cytogenetic landmarks into the draft sequence of the human genome. Nature 409, 953-958 (2001).
-
(2001)
Nature
, vol.409
, pp. 953-958
-
-
Cheung, V.G.1
-
58
-
-
0021153574
-
Separation of yeast chromosome-sized DNA's by pulsed field gradient gel electrophoresis
-
Schwartz, D. C. & Cantor, C. R. Separation of yeast chromosome-sized DNA's by pulsed field gradient gel electrophoresis. Cell 37, 67-75 (1984).
-
(1984)
Cell
, vol.37
, pp. 67-75
-
-
Schwartz, D.C.1
Cantor, C.R.2
-
59
-
-
0022577807
-
Fractionation of large mammalian DNA restriction fragments using vertical pulsed-field gradient gel electrophoresis
-
Gardiner, K., Laas, W. & Patterson, D. Fractionation of large mammalian DNA restriction fragments using vertical pulsed-field gradient gel electrophoresis. Somat. Cell Mol. Genet. 12, 185-195 (1986).
-
(1986)
Somat. Cell Mol. Genet.
, vol.12
, pp. 185-195
-
-
Gardiner, K.1
Laas, W.2
Patterson, D.3
-
60
-
-
0023349389
-
Cloning of large segments of exogenous DNA into yeast by mean artificial chromosome vector
-
Burke D. T., Carle, G. F. & Olson, M. V. Cloning of large segments of exogenous DNA into yeast by mean artificial chromosome vector. Science 236, 806-812 (1987).
-
(1987)
Science
, vol.236
, pp. 806-812
-
-
Burke, D.T.1
Carle, G.F.2
Olson, M.V.3
-
61
-
-
0025092046
-
Analysis of human chromosome 21: Correlation of physical and cytogenetic maps; gene and CpG island distributions
-
Gardiner, K. et al. Analysis of human chromosome 21: correlation of physical and cytogenetic maps; gene and CpG island distributions. EMBO J. 9, 25-34 (1990).
-
(1990)
EMBO J.
, vol.9
, pp. 25-34
-
-
Gardiner, K.1
-
62
-
-
0026738541
-
Continuum of overlapping clones spanning the entire human chromosome 21q
-
Chumakov, I. et al. Continuum of overlapping clones spanning the entire human chromosome 21q. Nature 359, 380-386 (1992).
-
(1992)
Nature
, vol.359
, pp. 380-386
-
-
Chumakov, I.1
-
63
-
-
0026593179
-
Long-distance restriction mapping of the proximal long arm of human chromosome 21 with Not I linking clones
-
Ichikawa, H. et al. Long-distance restriction mapping of the proximal long arm of human chromosome 21 with Not I linking clones. Proc. Natl Acad. Sci. USA 89, 23-27 (1992).
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 23-27
-
-
Ichikawa, H.1
-
64
-
-
0026703169
-
Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vector
-
Shizuya, H. et al. Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vector. Proc. Natl Acad. Sci. USA 89, 8794-8797 (1992).
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 8794-8797
-
-
Shizuya, H.1
-
65
-
-
0026600208
-
A contiguous Not I restriction map of band q22.3 of human chromosome 21
-
Wang, D., Fang, H., Cantor, C. R. & Smith, C. L. A contiguous Not I restriction map of band q22.3 of human chromosome 21. Proc. Natl Acad. Sci. USA 89, 3222-3226 (1992).
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 3222-3226
-
-
Wang, D.1
Fang, H.2
Cantor, C.R.3
Smith, C.L.4
-
66
-
-
0028221007
-
Preparation and screening of an arrayed human genomic library generated with the P1 cloning system
-
Shepherd, N. S. et al. Preparation and screening of an arrayed human genomic library generated with the P1 cloning system. Proc. Natl Acad. Sci. USA 91, 2629-2633 (1994).
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 2629-2633
-
-
Shepherd, N.S.1
-
67
-
-
0029585732
-
A high-fidelity physical map of human chromosome 21q in yeast artificial chromosomes
-
Korenberg, J. R. et al. A high-fidelity physical map of human chromosome 21q in yeast artificial chromosomes. Genome Res. 5, 427-443 (1995).
-
(1995)
Genome Res.
, vol.5
, pp. 427-443
-
-
Korenberg, J.R.1
-
68
-
-
13144294622
-
The international consortium to sequence human chromosome 21
-
Patterson, D. & Sakaki, Y. The international consortium to sequence human chromosome 21. Genome Digest 4, 9-10 (1997).
-
(1997)
Genome Digest
, vol.4
, pp. 9-10
-
-
Patterson, D.1
Sakaki, Y.2
-
69
-
-
0034682403
-
The DNA sequence of human chromosome 21
-
Hattori, M. et al. The DNA sequence of human chromosome 21. Nature 405, 311-319 (2000).
-
(2000)
Nature
, vol.405
, pp. 311-319
-
-
Hattori, M.1
-
70
-
-
1242296842
-
A comprehensive analysis of allelic methyiation status of CpG islands on human chromosome 21q
-
Yamada, Y. et al. A comprehensive analysis of allelic methyiation status of CpG islands on human chromosome 21q. Genome Res. 14, 247-266 (2004).
-
(2004)
Genome Res.
, vol.14
, pp. 247-266
-
-
Yamada, Y.1
-
71
-
-
12144287461
-
Novel RNAs identified from an in-depth analysis of the transcriptome of human chromosomes 21 and 22
-
Kampa D. et al. Novel RNAs identified from an in-depth analysis of the transcriptome of human chromosomes 21 and 22. Genome Res. 14, 331-342 (2004).
-
(2004)
Genome Res.
, vol.14
, pp. 331-342
-
-
Kampa, D.1
-
72
-
-
1542563409
-
Initial sequencing and comparative analysis of the mouse genome
-
Waterston, R. H. et al. Initial sequencing and comparative analysis of the mouse genome. Nature 420, 520-562 (2002).
-
(2002)
Nature
, vol.420
, pp. 520-562
-
-
Waterston, R.H.1
-
73
-
-
0242348738
-
Mouse models of Down syndrome: How useful can they be: Comparison of the gene content of human chromosome 21 with orthologous mouse genomic regions
-
Gardiner, K., Fortna, A., Bechtel, L. & Davisson, M. T. Mouse models of Down syndrome: how useful can they be: comparison of the gene content of human chromosome 21 with orthologous mouse genomic regions. Gene 318, 137-147 (2003).
-
(2003)
Gene
, vol.318
, pp. 137-147
-
-
Gardiner, K.1
Fortna, A.2
Bechtel, L.3
Davisson, M.T.4
-
74
-
-
0035941029
-
Blocks of limited haplotype diversity revealed by high-resolution scanning of human chromosome 21
-
Patil, N. et al. Blocks of limited haplotype diversity revealed by high-resolution scanning of human chromosome 21. Science 294, 1719-1723 (2001).
-
(2001)
Science
, vol.294
, pp. 1719-1723
-
-
Patil, N.1
-
75
-
-
0037403505
-
Global up-regulation of chromosome 21 gene expression in the developing Down syndrome brain
-
Mao, R., Zielke, C. L., Zielke, H. R. & Pevsner, J. Global up-regulation of chromosome 21 gene expression in the developing Down syndrome brain. Genomics 81, 457-467 (2003).
-
(2003)
Genomics
, vol.81
, pp. 457-467
-
-
Mao, R.1
Zielke, C.L.2
Zielke, H.R.3
Pevsner, J.4
-
76
-
-
0037115492
-
Transcriptome analysis of human autosomal trisomy
-
FitzPatrick, D. R. et al. Transcriptome analysis of human autosomal trisomy. Hum. Mol. Genet. 11, 3249-3256 (2002).
-
(2002)
Hum. Mol. Genet.
, vol.11
, pp. 3249-3256
-
-
FitzPatrick, D.R.1
-
77
-
-
18744387970
-
Human chromosome 21 gene expression atlas in the mouse
-
Reymond, A. et al. Human chromosome 21 gene expression atlas in the mouse. Nature 420, 582-586 (2002).
-
(2002)
Nature
, vol.420
, pp. 582-586
-
-
Reymond, A.1
-
78
-
-
18744369030
-
A gene expression map of human chromosome 21 orthologues in the mouse
-
Gitton, Y. et al. A gene expression map of human chromosome 21 orthologues in the mouse. Nature 429, 586-590 (2002).
-
(2002)
Nature
, vol.429
, pp. 586-590
-
-
Gitton, Y.1
-
79
-
-
0037012881
-
Large-scale transcriptional activity in chromosomes 21 and 22
-
Kapranov, P. et al. Large-scale transcriptional activity in chromosomes 21 and 22. Science 296, 916-919 (2002).
-
(2002)
Science
, vol.296
, pp. 916-919
-
-
Kapranov, P.1
-
80
-
-
0016711037
-
High resolution two-dimensional electrophoresis of proteins
-
O'Farrell, P. H. High resolution two-dimensional electrophoresis of proteins. J. Biol. Chem. 250, 4007-4021 (1975).
-
(1975)
J. Biol. Chem.
, vol.250
, pp. 4007-4021
-
-
O'Farrell, P.H.1
-
81
-
-
0018692397
-
The effect of trisomy 21 on the patterns of polypeptide synthesis in human fibroblasts
-
Weil, J. & Epstein, C. J. The effect of trisomy 21 on the patterns of polypeptide synthesis in human fibroblasts. Am. J. Hum. Genet. 31, 478-488 (1979).
-
(1979)
Am. J. Hum. Genet.
, vol.31
, pp. 478-488
-
-
Weil, J.1
Epstein, C.J.2
-
82
-
-
0019891516
-
Localization and quantitation of human superoxide dismutase using computerized 2-D gel electrophoresis
-
Brown, W. T., Dutkowski, R. & Darlington, G. J. Localization and quantitation of human superoxide dismutase using computerized 2-D gel electrophoresis. Biochem. Biophys. Res. Comm. 102, 675-681 (1981).
-
(1981)
Biochem. Biophys. Res. Comm.
, vol.102
, pp. 675-681
-
-
Brown, W.T.1
Dutkowski, R.2
Darlington, G.J.3
-
83
-
-
0020084153
-
Analysis of protein patterns in two-dimensional gels of cultured human cells with trisomy 21
-
Klose, J., Zeindl, E. & Sperling, K. Analysis of protein patterns in two-dimensional gels of cultured human cells with trisomy 21. Clin. Chem. 28, 987-992 (1982).
-
(1982)
Clin. Chem.
, vol.28
, pp. 987-992
-
-
Klose, J.1
Zeindl, E.2
Sperling, K.3
-
84
-
-
0020331748
-
Somatic cell approaches to Down's syndrome
-
Patterson, D., Jones, C., Scoggin, C., Miller, Y. E. & Graw, S. Somatic cell approaches to Down's syndrome. Ann. NY Acad. Sci. 396, 69-81 (1982).
-
(1982)
Ann. NY Acad. Sci.
, vol.396
, pp. 69-81
-
-
Patterson, D.1
Jones, C.2
Scoggin, C.3
Miller, Y.E.4
Graw, S.5
-
85
-
-
0020331747
-
Protein variations associated with Down's syndrome, chromosome 21, and Alzheimer's disease
-
Van Keuren, M. L., Goldman, D. & Merril, C. R. Protein variations associated with Down's syndrome, chromosome 21, and Alzheimer's disease. Ann. N.Y. Acad. Sci. 396, 55-67 (1982).
-
(1982)
Ann. N.Y. Acad. Sci.
, vol.396
, pp. 55-67
-
-
Van Keuren, M.L.1
Goldman, D.2
Merril, C.R.3
-
86
-
-
3543023287
-
Direct proteomic mapping of the lung microvascular endothelial cell surface in vivo and in cell culture
-
Durr, E. et al. Direct proteomic mapping of the lung microvascular endothelial cell surface in vivo and in cell culture. Nature Biotechnol. 22, 985-992 (1994).
-
(1994)
Nature Biotechnol.
, vol.22
, pp. 985-992
-
-
Durr, E.1
-
87
-
-
0343376097
-
Difference gel electrophoresis: A single gel method for detecting changes in protein extracts
-
Unlu, M., Morgan, M. E. & Minden, J. S. Difference gel electrophoresis: a single gel method for detecting changes in protein extracts. Electrophoresis 18, 2071-2077 (1997).
-
(1997)
Electrophoresis
, vol.18
, pp. 2071-2077
-
-
Unlu, M.1
Morgan, M.E.2
Minden, J.S.3
-
88
-
-
0000864479
-
-
(ed. Popko, B.) (Kluwer Academic/Plenum, New York)
-
Davisson, M. T. & Costa, A. C. S. in Advances in Neurochemistry Vol. 9 (ed. Popko, B.) 297-327 (Kluwer Academic/Plenum, New York, 1999).
-
(1999)
Advances in Neurochemistry
, vol.9
, pp. 297-327
-
-
Davisson, M.T.1
Costa, A.C.S.2
-
89
-
-
0014665152
-
Autosomal trisomy in a chimpanzee: Resemblance to Down's syndrome
-
McClure, H. M., Beiden, K. H., Pieper, W. A. & Jacobson, C. B. Autosomal trisomy in a chimpanzee: resemblance to Down's syndrome. Science 165, 1010-1012 (1969).
-
(1969)
Science
, vol.165
, pp. 1010-1012
-
-
McClure, H.M.1
Beiden, K.H.2
Pieper, W.A.3
Jacobson, C.B.4
-
90
-
-
2642575083
-
DNA sequence and comparative analysis of chimpanzee chromosome 22
-
Watanabe, H. et al. DNA sequence and comparative analysis of chimpanzee chromosome 22. Nature 429, 382-388 (2004).
-
(2004)
Nature
, vol.429
, pp. 382-388
-
-
Watanabe, H.1
-
91
-
-
0038492433
-
Divergence of the genes on human chromosome 21 between human and other hominoids and variation of substitution rates among transcription units
-
Shi, J. et al. Divergence of the genes on human chromosome 21 between human and other hominoids and variation of substitution rates among transcription units. Proc. Natl Acad. Sci. USA 100, 8331-8336 (2003).
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 8331-8336
-
-
Shi, J.1
-
92
-
-
0016202463
-
Trisomy in the fetal backcross progeny of male and female metacentric heterozygotes of the mouse. I
-
Gropp, A., Giers, D. & Kolbus, U. Trisomy in the fetal backcross progeny of male and female metacentric heterozygotes of the mouse. I. Cytogenet. Cell Genet. 13, 511-535 (1974).
-
(1974)
Cytogenet. Cell Genet.
, vol.13
, pp. 511-535
-
-
Gropp, A.1
Giers, D.2
Kolbus, U.3
-
93
-
-
13144252699
-
-
(eds de la Cruz, F. F. & Gerald, P. S.) (Univ. Park Press, Baltimore)
-
Epstein, C. J. in Trisomy 21 (Down Syndrome) Research Perspectives (eds de la Cruz, F. F. & Gerald, P. S.) 263-271 (Univ. Park Press, Baltimore, 1981).
-
(1981)
Trisomy 21 (Down Syndrome) Research Perspectives
, pp. 263-271
-
-
Epstein, C.J.1
-
94
-
-
0018667723
-
Assignment of the gene for cytoplasmic superoxide dismutase (SOD1) to a region of chromosome 16 and of Hprt to a region of the X chromosome in the mouse
-
Francke, U. & Taggart, R. T. Assignment of the gene for cytoplasmic superoxide dismutase (SOD1) to a region of chromosome 16 and of Hprt to a region of the X chromosome in the mouse. Proc. Natl Acad. Sci. USA 76, 5230-5233 (1979).
-
(1979)
Proc. Natl. Acad. Sci. USA
, vol.76
, pp. 5230-5233
-
-
Francke, U.1
Taggart, R.T.2
-
95
-
-
0019190133
-
Chromosome 21 of man, 22 of the great apes and 16 of the mouse
-
Polani, P., E. & Adinolfi, M. Chromosome 21 of man, 22 of the great apes and 16 of the mouse. Dev. Med. Child Neurol. 22, 223-233 (1980).
-
(1980)
Dev. Med. Child Neurol.
, vol.22
, pp. 223-233
-
-
Polani, P.E.1
Adinolfi, M.2
-
96
-
-
0019974174
-
Trisomy 16 in the mouse fetus associated with generalized edema and cardiovascular and urinary tract anomalies
-
Miyabara, S., Gropp, A. & Winking, H. Trisomy 16 in the mouse fetus associated with generalized edema and cardiovascular and urinary tract anomalies. Teratology 25, 369-380 (1982).
-
(1982)
Teratology
, vol.25
, pp. 369-380
-
-
Miyabara, S.1
Gropp, A.2
Winking, H.3
-
97
-
-
0022871707
-
Autosomal aneuploidy in mice: Generation and developmental consequences
-
Gearhart, J. M., Davisson, M. & Oster-Granite, M. L. Autosomal aneuploidy in mice: generation and developmental consequences. Brain Res. Bull. 16, 789-801 (1986).
-
(1986)
Brain Res. Bull.
, vol.16
, pp. 789-801
-
-
Gearhart, J.M.1
Davisson, M.2
Oster-Granite, M.L.3
-
98
-
-
0025663975
-
-
(eds Patterson, D. & Epstein, C. J.) (Wiley-Liss, New York)
-
Davisson, M. T., Schmidt, C. & Akeson E. C. in Molecular Genetics of Chromosome 21 and Down Syndrome (eds Patterson, D. & Epstein, C. J.) 263-280 (Wiley-Liss, New York, 1990).
-
(1990)
Molecular Genetics of Chromosome 21 and Down Syndrome
, pp. 263-280
-
-
Davisson, M.T.1
Schmidt, C.2
Akeson, E.C.3
-
100
-
-
0029114706
-
A mouse model for Down syndrome exhibits learning and behaviour deficits
-
Reeves, R. H. et al. A mouse model for Down syndrome exhibits learning and behaviour deficits. Nature Genet. 11, 177-183 (1995).
-
(1995)
Nature Genet.
, vol.11
, pp. 177-183
-
-
Reeves, R.H.1
-
101
-
-
10544243361
-
Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome
-
Holtzman, D. M. et al. Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome. Proc. Natl Acad. Sci. USA 93, 13333-13338 (1996).
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 13333-13338
-
-
Holtzman, D.M.1
-
102
-
-
0035208315
-
Age-related deficits in context discrimination learning in Ts65Dn mice that model Down syndrome and Alzheimer's disease
-
Hyde, L. A. & Crnic, L. S. Age-related deficits in context discrimination learning in Ts65Dn mice that model Down syndrome and Alzheimer's disease. Behav. Neurosci. 115, 1239-1246 (2001).
-
(2001)
Behav. Neurosci.
, vol.115
, pp. 1239-1246
-
-
Hyde, L.A.1
Crnic, L.S.2
-
103
-
-
0036467052
-
Craniofacial phenotypes in segmentally trisomic mouse models for Down syndrome
-
Richtsmeier, J. T., Zumwalt, A., Carlson, E. J., Epstein, C. J. & Reeves, R. H. Craniofacial phenotypes in segmentally trisomic mouse models for Down syndrome. Am. J. Med. Genet. 107, 317-324 (2002).
-
(2002)
Am. J. Med. Genet.
, vol.107
, pp. 317-324
-
-
Richtsmeier, J.T.1
Zumwalt, A.2
Carlson, E.J.3
Epstein, C.J.4
Reeves, R.H.5
-
104
-
-
0041632362
-
App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of Down syndrome
-
Cataldo, A. M. et al. App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of Down syndrome. J. Neurosci. 23, 6788-6792 (2003).
-
(2003)
J. Neurosci.
, vol.23
, pp. 6788-6792
-
-
Cataldo, A.M.1
-
105
-
-
3242767625
-
Gait dynamics in trisomic mice: Quantitative neurological traits of Down syndrome
-
Hampton, T. G., Stasko, M. R., Kale, A., Amende, I. & Costa, A. C. Gait dynamics in trisomic mice: quantitative neurological traits of Down syndrome. Physiol. Behav. 82, 381-389 (2004).
-
(2004)
Physiol. Behav.
, vol.82
, pp. 381-389
-
-
Hampton, T.G.1
Stasko, M.R.2
Kale, A.3
Amende, I.4
Costa, A.C.5
-
106
-
-
3042612213
-
Down syndrome mouse models Ts65Dn, Ts1Cje, and Ms1Cje/Ts 65SDn exhibit variable severity of cerebellar phenotypes
-
Olson, L. E. et al. Down syndrome mouse models Ts65Dn, Ts1Cje, and Ms1Cje/Ts65SDn exhibit variable severity of cerebellar phenotypes. Dev. Dyn. 230, 581-589 (2004).
-
(2004)
Dev. Dyn.
, vol.230
, pp. 581-589
-
-
Olson, L.E.1
-
107
-
-
4043159976
-
Experimental parameters affecting the morris water maze performance of a mouse model of Down syndrome
-
Stasko, M. R. & Costa, A. C. S. Experimental parameters affecting the morris water maze performance of a mouse model of Down syndrome. Behav. Brain Res. 154, 1-17 (2004).
-
(2004)
Behav. Brain Res.
, vol.154
, pp. 1-17
-
-
Stasko, M.R.1
Costa, A.C.S.2
-
108
-
-
3543110316
-
Transcript level alterations reflect gene dosage effects across multiple tissues in a mouse model of Down syndrome
-
Kahlem, P. et al. Transcript level alterations reflect gene dosage effects across multiple tissues in a mouse model of Down syndrome. Genome Res. 14, 1258-1267 (2004).
-
(2004)
Genome Res.
, vol.14
, pp. 1258-1267
-
-
Kahlem, P.1
-
109
-
-
0032568615
-
Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities
-
Sago, H. et al. Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities. Proc. Natl Acad. Sci. USA 95, 6256-6261 (1998).
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 6256-6261
-
-
Sago, H.1
-
110
-
-
0033756144
-
Genetic dissection of region associated with behavioral abnormalities in mouse models for Down syndrome
-
Sago, H. et al. Genetic dissection of region associated with behavioral abnormalities in mouse models for Down syndrome. Pediatr. Res. 48, 606-613 (2000).
-
(2000)
Pediatr. Res.
, vol.48
, pp. 606-613
-
-
Sago, H.1
-
111
-
-
0042420452
-
Global disruption of the cerebellar transcriptome in a Down syndrome mouse model
-
Saran, N. G., Pletcher, M. T., Natale, J. E., Cheng, Y. & Reeves, R. H. Global disruption of the cerebellar transcriptome in a Down syndrome mouse model. Hum. Mol. Genet. 12, 2013-2019 (2003).
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 2013-2019
-
-
Saran, N.G.1
Pletcher, M.T.2
Natale, J.E.3
Cheng, Y.4
Reeves, R.H.5
-
112
-
-
3543097554
-
Gene expression from the aneuploid chromosome in a trisomy mouse model of Down syndrome
-
Lyle, R., Gehrig, C., Neergaard-Henrichsen, C., Deutsch, S. & Antonarakis, S. E. Gene expression from the aneuploid chromosome in a trisomy mouse model of Down syndrome. Genome Res. 14, 1268-1274 (2004).
-
(2004)
Genome Res.
, vol.14
, pp. 1268-1274
-
-
Lyle, R.1
Gehrig, C.2
Neergaard-Henrichsen, C.3
Deutsch, S.4
Antonarakis, S.E.5
-
113
-
-
3242794941
-
Dosage-dependent over-expresstan of genes in the trisomic region of Ts 1Cje mouse model for Down syndrome
-
Amano, K. et al. Dosage-dependent over-expresstan of genes in the trisomic region of Ts1Cje mouse model for Down syndrome. Hum. Mol. Genet. 13, 1333-1340 (2004).
-
(2004)
Hum. Mol. Genet.
, vol.13
, pp. 1333-1340
-
-
Amano, K.1
-
114
-
-
0023444192
-
Transgenic mice with increased Cu/Zn-superoxide dismutase activity: Animal model of dosage effects in Down syndrome
-
Epstein, C. J. et al. Transgenic mice with increased Cu/Zn-superoxide dismutase activity: animal model of dosage effects in Down syndrome. Proc. Natl Acad. Sci. 84, 8044-8088 (1987).
-
(1987)
Proc. Natl. Acad. Sci.
, vol.84
, pp. 8044-8088
-
-
Epstein, C.J.1
-
115
-
-
0026096819
-
Down's syndrome: Morphological remodeling and increased complexity in the neuromuscular junction of transgenic CuZn-superoxide dismutase mice
-
Avraham, K. B., Sugarman, H., Rotshenker, S. & Groner, Y. Down's syndrome: morphological remodeling and increased complexity in the neuromuscular junction of transgenic CuZn-superoxide dismutase mice. J. Neurocytol. 20, 208-215 (1991).
-
(1991)
J. Neurocytol.
, vol.20
, pp. 208-215
-
-
Avraham, K.B.1
Sugarman, H.2
Rotshenker, S.3
Groner, Y.4
-
116
-
-
0031865781
-
Reversible impairment of long-term potentiation in transgenic Cu/Zn-SOD mice
-
Gahtan, E., Auerbach, J. M., Groner, Y. & Segal, M. Reversible impairment of long-term potentiation in transgenic Cu/Zn-SOD mice. Eur. J. Neurosci. 10, 538-544 (1998).
-
(1998)
Eur. J. Neurosci.
, vol.10
, pp. 538-544
-
-
Gahtan, E.1
Auerbach, J.M.2
Groner, Y.3
Segal, M.4
-
117
-
-
1642268979
-
Functional and morphological alterations in compound transgenic mice overexpreszing Cu/Zn superoxide dismutaze and amyloid precursor protein
-
Harris-Cerruti, C. et al. Functional and morphological alterations in compound transgenic mice overexpreszing Cu/Zn superoxide dismutaze and amyloid precursor protein. Eur. J. Neurosci. 19, 1174-1190 (2004).
-
(2004)
Eur. J. Neurosci.
, vol.19
, pp. 1174-1190
-
-
Harris-Cerruti, C.1
-
118
-
-
0037186074
-
Altered metabolism of the amyloid β precursor protein is associated with mitochondrial dysfunction in Down's syndrome
-
Busciglio J. et al. Altered metabolism of the amyloid β precursor protein is associated with mitochondrial dysfunction in Down's syndrome. Neuron 33, 677-688 (2002).
-
(2002)
Neuron
, vol.33
, pp. 677-688
-
-
Busciglio, J.1
-
119
-
-
0032501224
-
Altered brain glucose metabolism in transgenic-PFKL mice with elevated L-phosphofructokinase: In vivo NMR studies
-
Peled-Kamar, M., Degani, H., Bendel, P., Margalit, R. & Groner, Y. Altered brain glucose metabolism in transgenic-PFKL mice with elevated L-phosphofructokinase: in vivo NMR studies. Brain Res. 810, 138-145 (1998).
-
(1998)
Brain Res.
, vol.810
, pp. 138-145
-
-
Peled-Kamar, M.1
Degani, H.2
Bendel, P.3
Margalit, R.4
Groner, Y.5
-
120
-
-
1642456615
-
Motor phenotypic alterations in TgDyrk1 a transgenic mice implicate DYRK1A in Down syndrome motor dysfunction
-
Martinez de Lagrán, M. et al. Motor phenotypic alterations in TgDyrk1 a transgenic mice implicate DYRK1A in Down syndrome motor dysfunction. Neurobiol. Dis. 15, 132-142 (2004).
-
(2004)
Neurobiol. Dis.
, vol.15
, pp. 132-142
-
-
Martinez De Lagrán, M.1
-
121
-
-
0033852958
-
Mice trisomic for a bacterial artificial chromosome with the single-minded 2 gene (Sim2) show phenotypes similar to some of those present in the partial trisomy 16 mouse models of Down syndrome
-
Chrast, R. et al. Mice trisomic for a bacterial artificial chromosome with the single-minded 2 gene (Sim2) show phenotypes similar to some of those present in the partial trisomy 16 mouse models of Down syndrome. Hum. Mol. Genet. 9, 1853-1864 (2000).
-
(2000)
Hum. Mol. Genet.
, vol.9
, pp. 1853-1864
-
-
Chrast, R.1
-
122
-
-
85047691446
-
Harm avoidance, anxiety, and response to novelty in the adolescent S- t00β transgenic mouse: Role of serotonin and relevance to Down syndrome
-
Bell, K., Shokrian, D., Potenzieri, C. & Whitaker-Azmitia, P. M. Harm avoidance, anxiety, and response to novelty in the adolescent S- t00β transgenic mouse: role of serotonin and relevance to Down syndrome. Neuropsychopharmacology 28, 1810-1816 (2003).
-
(2003)
Neuropsychopharmacology
, vol.28
, pp. 1810-1816
-
-
Bell, K.1
Shokrian, D.2
Potenzieri, C.3
Whitaker-Azmitia, P.M.4
-
123
-
-
0347479365
-
Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis
-
Wolvetang, E. J. et al. Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis. Neurobiol. Dis. 14, 349-356 (2003).
-
(2003)
Neurobiol. Dis.
, vol.14
, pp. 349-356
-
-
Wolvetang, E.J.1
-
124
-
-
0010657910
-
-
(eds Bailey, D. B., Bruer, J. T., Symons, F. J. & Lichtman, J. W.) (Paul H. Brooks, Baltimore)
-
Horton, J. C. in Critical Thinking About Critical Periods (eds Bailey, D. B., Bruer, J. T., Symons, F. J. & Lichtman, J. W.) (Paul H. Brooks, Baltimore, 2001).
-
(2001)
Critical Thinking about Critical Periods
-
-
Horton, J.C.1
-
125
-
-
0038687498
-
The neuropsychology of Down syndrome: Evidence for hippocampal dysfunction
-
Pennington, B. F., Moon, J., Edgin, J., Stedron, J. & Nadel, L. The neuropsychology of Down syndrome: evidence for hippocampal dysfunction. Child. Dev. 74, 75-93 (2003).
-
(2003)
Child. Dev.
, vol.74
, pp. 75-93
-
-
Pennington, B.F.1
Moon, J.2
Edgin, J.3
Stedron, J.4
Nadel, L.5
-
126
-
-
0032927816
-
MRI volumes of the hippocampus and amygdala in adults with Down's syndrome with and without dementia
-
Aylward, E. H. et al. MRI volumes of the hippocampus and amygdala in adults with Down's syndrome with and without dementia. Am. J. Psychiatry 156, 564-568 (1999).
-
(1999)
Am. J. Psychiatry
, vol.156
, pp. 564-568
-
-
Aylward, E.H.1
-
127
-
-
0035836647
-
Amygdala and hippocampal volumes in children with Down syndrome: A high-resolution MRI study
-
Pinter, J. D. et al. Amygdala and hippocampal volumes in children with Down syndrome: a high-resolution MRI study. Neurology 56, 972-974 (2001).
-
(2001)
Neurology
, vol.56
, pp. 972-974
-
-
Pinter, J.D.1
-
128
-
-
4644250821
-
Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome
-
Kleschevnikov, A. M. et al. Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome. J. Neurosci. 15, 8153-8160 (2004).
-
(2004)
J. Neurosci.
, vol.15
, pp. 8153-8160
-
-
Kleschevnikov, A.M.1
-
129
-
-
0032925810
-
Transchromsomal mouse embryonic stem cell lines and chimeric mice that contain freely segregating segments of human chromosome 21
-
Hernandez, D., Mee, P. J., Martin, J. E., Tybulewicz, V. L. J. & Fisher, E. M. C. Transchromsomal mouse embryonic stem cell lines and chimeric mice that contain freely segregating segments of human chromosome 21. Hum. Mol. Genet. 8, 923-933 (1999).
-
(1999)
Hum. Mol. Genet.
, vol.8
, pp. 923-933
-
-
Hernandez, D.1
Mee, P.J.2
Martin, J.E.3
Tybulewicz, V.L.J.4
Fisher, E.M.C.5
-
130
-
-
14344275376
-
Mice containing a human chromosome 21 model behavioral impairment and cardiac anomalies of Down's syndrome
-
Shinohara, T. et al. Mice containing a human chromosome 21 model behavioral impairment and cardiac anomalies of Down's syndrome. Hum. Mol. Genet. 10, 1163-1175 (2001).
-
(2001)
Hum. Mol. Genet.
, vol.10
, pp. 1163-1175
-
-
Shinohara, T.1
-
131
-
-
7444231620
-
A chromosome 21 critical region does not cause specific Down syndrome phenotypes
-
Olson, L. E., Richtsmeier, J. T., Leszl, J. & Reeves, R. H. A chromosome 21 critical region does not cause specific Down syndrome phenotypes. Science 306, 687-690 (2004).
-
(2004)
Science
, vol.306
, pp. 687-690
-
-
Olson, L.E.1
Richtsmeier, J.T.2
Leszl, J.3
Reeves, R.H.4
-
132
-
-
4644247617
-
Building protein interaction maps for Down's syndrome
-
Gardiner, K., Davisson, M. T. & Crnic, L. S. Building protein interaction maps for Down's syndrome. Brief. Funct. Genomic Proteomic 3, 142-156 (2004).
-
(2004)
Brief. Funct. Genomic Proteomic
, vol.3
, pp. 142-156
-
-
Gardiner, K.1
Davisson, M.T.2
Crnic, L.S.3
-
133
-
-
0034947408
-
-
Correspondence
-
Reynolds, T. M. Correspondence in J. Clin. Pathol. 54, 573-574 (2001).
-
(2001)
J. Clin. Pathol.
, vol.54
, pp. 573-574
-
-
Reynolds, T.M.1
-
134
-
-
3442882264
-
A look at a Hispanic and African American population in an urban prenatal diagnostic center: Referral reasons, amniocentesis acceptance, and abnormalities detected
-
Baker, D., Teklehaimanot, S., Hassan, R. & Guze, C. A look at a Hispanic and African American population in an urban prenatal diagnostic center: referral reasons, amniocentesis acceptance, and abnormalities detected. Genet. Med. 6, 211-218 (2004).
-
(2004)
Genet. Med.
, vol.6
, pp. 211-218
-
-
Baker, D.1
Teklehaimanot, S.2
Hassan, R.3
Guze, C.4
-
135
-
-
0021879146
-
Chorionic villus sampling for first-trimester prenatal diagnosis: Northwestern University program
-
Elias, S. et al. Chorionic villus sampling for first-trimester prenatal diagnosis: Northwestern University program. Am. J. Obstet. Gynecol. 152, 204-213 (1985).
-
(1985)
Am. J. Obstet. Gynecol.
, vol.152
, pp. 204-213
-
-
Elias, S.1
-
136
-
-
0021247504
-
An association between low maternal serum α-fetoprotein and fetal chromosomal abnormalities
-
Merkatz, I. R., Nitowsky, H. M., Maori, J. N. & Johnson, W. E. An association between low maternal serum α-fetoprotein and fetal chromosomal abnormalities. Am. J. Obstet. Gynecol. 148, 886-894 (1984).
-
(1984)
Am. J. Obstet. Gynecol.
, vol.148
, pp. 886-894
-
-
Merkatz, I.R.1
Nitowsky, H.M.2
Maori, J.N.3
Johnson, W.E.4
-
137
-
-
1642555627
-
Screening for Down's syndrome in early and late first and second trimester using six maternal serum markers
-
Christiansen, M. et al. Screening for Down's syndrome in early and late first and second trimester using six maternal serum markers. Clin. Genet. 65, 11-16 (2004).
-
(2004)
Clin. Genet.
, vol.65
, pp. 11-16
-
-
Christiansen, M.1
-
138
-
-
0026562612
-
Fetal nuchal translucency: Ultrasound screening for chromosomal defects in first trimester of pregnancy
-
Nicolaides, K. H., Azar, G., Byrne, D., Mansur, C. & Marks, K. Fetal nuchal translucency: ultrasound screening for chromosomal defects in first trimester of pregnancy. BMJ 304, 867-869 (1992).
-
(1992)
BMJ
, vol.304
, pp. 867-869
-
-
Nicolaides, K.H.1
Azar, G.2
Byrne, D.3
Mansur, C.4
Marks, K.5
-
139
-
-
0027080020
-
Detection of fetal cells with 47,XY,+ 21 karyotype in maternal peripheral blood
-
Bianchi, D. W. et al. Detection of fetal cells with 47,XY,+21 karyotype in maternal peripheral blood. Hum. Genet. 90, 368-370 (1992).
-
(1992)
Hum. Genet.
, vol.90
, pp. 368-370
-
-
Bianchi, D.W.1
-
140
-
-
0029817622
-
Ethical and legal issues regarding selective abortion of fetuses with Down syndrome
-
Glover, N. M. & Glover, S. J. Ethical and legal issues regarding selective abortion of fetuses with Down syndrome. Ment. Retard. 34, 207-214 (1996).
-
(1996)
Ment. Retard.
, vol.34
, pp. 207-214
-
-
Glover, N.M.1
Glover, S.J.2
-
141
-
-
0032845227
-
Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome
-
James, S. J. et al. Abnormal folate metabolism and mutation in the methylenetetrahydrofolate reductase gene may be maternal risk factors for Down syndrome. Am. J. Clin. Nutr. 70, 495-501 (1999).
-
(1999)
Am. J. Clin. Nutr.
, vol.70
, pp. 495-501
-
-
James, S.J.1
-
142
-
-
3142737186
-
Maternal metabolic phenotype and risk of Down syndrome: Beyond genetics
-
James, S. J. Maternal metabolic phenotype and risk of Down syndrome: beyond genetics. Am. J. Med. Genet. 127 (Part A), 1-4 (2004).
-
(2004)
Am. J. Med. Genet.
, vol.127
, Issue.PART A
, pp. 1-4
-
-
James, S.J.1
-
143
-
-
0034969415
-
Homocysteine metabolism in children with Down syndrome: In vitro modulation
-
Pogribna, M. et al. Homocysteine metabolism in children with Down syndrome: in vitro modulation. Am. J. Hum. Genet. 69, 88-95 (2001).
-
(2001)
Am. J. Hum. Genet.
, vol.69
, pp. 88-95
-
-
Pogribna, M.1
-
144
-
-
0242585035
-
Frequency of Down's syndrome and neural-tube defects in the same family
-
Barkai, G., Arbuzova, S., Berkenstadt, M., Heifetz, S. & Cuckle, H. Frequency of Down's syndrome and neural-tube defects in the same family. Lancet 361, 1331-1335 (2003).
-
(2003)
Lancet
, vol.361
, pp. 1331-1335
-
-
Barkai, G.1
Arbuzova, S.2
Berkenstadt, M.3
Heifetz, S.4
Cuckle, H.5
-
145
-
-
0035319804
-
To err (meiotically) is human: The genesis of human aneuploidy
-
Hassold, T. & Hunt, P. To err (meiotically) is human: the genesis of human aneuploidy. Nature Rev. Genet. 2, 280-291 (2001).
-
(2001)
Nature Rev. Genet.
, vol.2
, pp. 280-291
-
-
Hassold, T.1
Hunt, P.2
-
146
-
-
0021749558
-
Advanced grandmaternal age on the mother's side - A risk of giving rise to trisomy 21
-
Aagesen, L., Grinsted, J. & Mikkelsen, M. Advanced grandmaternal age on the mother's side - a risk of giving rise to trisomy 21. Ann. Hum. Genet. 48, 297-302 (1984).
-
(1984)
Ann. Hum. Genet.
, vol.48
, pp. 297-302
-
-
Aagesen, L.1
Grinsted, J.2
Mikkelsen, M.3
-
147
-
-
0017669504
-
Grandmaternal age at birth of parents of children with trisomy
-
Papp, Z., Varadi, E. & Szabo, Z. Grandmaternal age at birth of parents of children with trisomy. Hum. Genet. 39, 221-224 (1977).
-
(1977)
Hum. Genet.
, vol.39
, pp. 221-224
-
-
Papp, Z.1
Varadi, E.2
Szabo, Z.3
-
148
-
-
0000179316
-
Precision of genetic adaptation
-
Muller, H. J. Precision of genetic adaptation. Harvey Lect. 43, 165-229 (1948).
-
(1948)
Harvey Lect.
, vol.43
, pp. 165-229
-
-
Muller, H.J.1
|