Hippocampal volume and neuronal number in Ts65Dn mice: A murine model of Down syndrome

Neuroscience Letters

Volumn 253, Issue 3, 1998, Pages 175-178

  Insausti, A M ^a   Megias M ^a   Crespo, D ^a   Cruz Orive, L M ^b   Dierssen, M ^a   Vallina, T F ^a   Insausti, R ^c   Florez J ^a  

^a UNIVERSITY OF CANTABRIA   (Spain)

^b UNIVERSITY OF CANTABRIA   (Spain)

^c UNIVERSITY OF NAVARRA   (Spain)

Author keywords

Down syndrome; Hippocampus; Memory; Neuron number; Stereology; Ts65Dn mouse

Indexed keywords

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL VOLUME; DOWN SYNDROME; HIPPOCAMPUS; HISTOPATHOLOGY; MOUSE; NERVE CELL; NONHUMAN; PATHOLOGICAL ANATOMY; PRIORITY JOURNAL; SPATIAL MEMORY;

ANIMALS; CELL COUNT; DENTATE GYRUS; DISEASE MODELS, ANIMAL; DOWN SYNDROME; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MICE; MICE, NEUROLOGIC MUTANTS; TRISOMY;

EID: 18244415365     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(98)00641-7     Document Type: Article

References (19)

1. Amaral, D.G. and Witter, M.P., Hippocampal formation. In G. Paxinos (Ed.), The Rat Nervous System, 2nd. edn., Academic Press, San Diego, CA, 1995, pp. 443-493.
2. Angevine J.B. Time of neuron origin in the hippocampal region. An autoradiographic study in the mouse. Exp. Neurol. Suppl. 13:1965;1-70.
3. Bambrick L.L., Yarowsky P.J., Krueger B.K. Glutamate as a hippocampal survival factor: an inherited defect in the trisomy 16 mouse. Proc. Natl. Acad. Sci. USA. 21:1995;9692-9696.
4. Busciglio J., Yankner B.A. Apoptosis and increased generation of reactive species in Down's syndrome neurons in vitro. Nature. 378:1995;776-779.
5. Crespo D., Stanfield B.B., Cowan W.M. Evidence that late-generated granule cells do not simply replace earlier formed neurons in the rat dentate gyrus. Exp. Brain Res. 62:1986;541-548.
6. Cruz-Orive L.M., Weibel E.R. Recent stereological methods for cell biology: a brief survey. Am. J. Physiol. 258:1990;L148-L156.
7. Davisson, M.T., Schmidt, C., Reeves, R.H., Irving, N.G., Akeson, E.C., Harris, B.S. and Bronson, R.T., Segmental trisomy as a mouse model for Down Syndrome. In C.J. Epstein (Ed.), The Phenotypic Mapping of Down Syndrome and Other Aneuploid Conditions, Wiley-Liss, New York, NY, 1993, pp. 117-133.
8. Dierssen M., Vallina I.F., Baamonde C., Lumbreras M.A., Martínez-Cue C., Calatayud S.G., Flórez J. Impaired cyclic AMP production in the hippocampus of a Down syndrome murine model. Dev. Brain Res. 95:1996;122-124.
9. Dierssen M., Vallina I.F., Baamonde C., Calatayud S.G., Lumbreras M.A., Flórez J. Alterations of central noradrenergic transmission in Ts65Dn mouse, a model for Down syndrome. Brain Res. 749:1997;238-244.
10. Epstein C.J., Cox D.R., Epstein L. Mouse trisomy 16: an animal model of human trisomy 21 (Down Syndrome). Ann. N.Y. Acad. Sci. 450:1985;157-168.
11. Escorihuela R.M., Fernández-Teruel A., Vallina I.F., Baamonde C., Lumbreras M.A., Dierssen M., Tobena A., Florez J. A behavioral assessment of Ts65Dn mice: a putative Down syndrome model. Neurosci. Lett. 199:1995;143-146.
12. Gundersen H.G.J., Jensen E.B. The efficiency of systematic sampling in stereology and its prediction. J. Microsc. 147:1987;229-263.
13. Haydar T.F., Blue M.E., Molliver M.E., Krueger B.K., Yarowsky P.J. Consequences of trisomy 16 for mouse brain development: corticogenesis in a model of Down syndrome. J. Neuroscience. 16:1996;6175-6182.
14. Holtzman D.M., Santucci D., Kilbridge J., Chua-Couzens J., Fontana D.J., Daniels S.E., Johnson R.M., Chen K., Sun Y., Carlson E., Alleva E., Epstein C.J., Mobley W.C. Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome. Proc. Natl. Acad. Sci. USA. 93:1996;13333-13338.
15. Korenberg J.R., Chen X.N., Schipper R., Sun Z., Gonosky R., Gerwehr S., Carpenter N., Daumer C., Digman P., Disteche C., Graham J.M., Hudgins L., Park J.P., Pueschel S., Sack G., Say B., Suchuffenhauer S., Soukuyp S., Ymanaka T. Down syndrome phenotypes: the consequences of chromosomal imbalance. Proc. Natl. Acad. Sci. USA. 91:1994;4997-5001.
16. Megías M., Verduga R., Dierssen M., Florez J., Insausti R., Crespo D. Cholinergic, serotonergic and catecholaminergic neurons are not affected in Ts65Dn mice. NeuroReport. 8:1997;3475-3478.
17. Reeve R.H., Irving N.G., Moran T.H., Wohn A., Kitt C., Sisodia S.S., Schmidt C., Bronson R.T., Davisson M.T. A mouse model for Down syndrome exhibits learning and behaviour deficits. Nat. Genet. 11:1995;177-183.
18. Sawa A., Oyama F., Cairns N.J., Amano N., Matsushita M. Aberrant expression of bcl-2 gene family in Downs syndrome brains. Mol. Brain Res. 48:1997;53-59.
19. West M.J., Østergaard K., Andreassen O.A., Finsen B. Estimation of the number of somatostatin neurons in the striatum: an in situ hybridization study using the optical fractionator method. J. Comp. Neurol. 370:1996;11-22.