메뉴 건너뛰기




Volumn 91, Issue 1, 2010, Pages 1-22

Communication breaks-Down: From neurodevelopment defects to cognitive disabilities in Down syndrome

Author keywords

Alzheimer's disease; Animal models; Cognitive disabilities; Developmental defects; Down syndrome; Neurodegeneration; Neurogenesis; Trisomy

Indexed keywords

ALPHA TOCOPHEROL; AMYLOID BETA PROTEIN; BILOBALIDE; CHOLINESTERASE INHIBITOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DIZOCILPINE; DONEPEZIL; DUAL SPECIFICITY PHOSPHATASE; ESTRADIOL; FLUOXETINE; GLYCOGEN SYNTHASE KINASE 3BETA; GUANINE NUCLEOTIDE EXCHANGE FACTOR; LITHIUM; MEMANTINE; MINOCYCLINE; NOOTROPIC AGENT; PENTETRAZOLE; PICROTOXIN; PIRACETAM; PLACEBO; RIVASTIGMINE; SGS 111; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR NFAT; UBIDECARENONE; UNCLASSIFIED DRUG;

EID: 77952955690     PISSN: 03010082     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pneurobio.2010.01.003     Document Type: Review
Times cited : (111)

References (332)
  • 4
    • 0034748652 scopus 로고    scopus 로고
    • Differential gene expression studies to explore the molecular pathophysiology of Down syndrome
    • Antonarakis S.E., Lyle R., Chrast R., Scott H.S. Differential gene expression studies to explore the molecular pathophysiology of Down syndrome. Brain Res. Brain Res. Rev. 2001, 36:265-274.
    • (2001) Brain Res. Brain Res. Rev. , vol.36 , pp. 265-274
    • Antonarakis, S.E.1    Lyle, R.2    Chrast, R.3    Scott, H.S.4
  • 9
    • 0037176537 scopus 로고    scopus 로고
    • Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: a gene expression study
    • Bahn S., Mimmack M., Ryan M., Caldwell M.A., Jauniaux E., Starkey M., Svendsen C.N. Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: a gene expression study. Lancet 2002, 359:310-315.
    • (2002) Lancet , vol.359 , pp. 310-315
    • Bahn, S.1    Mimmack, M.2    Ryan, M.3    Caldwell, M.A.4    Jauniaux, E.5    Starkey, M.6    Svendsen, C.N.7
  • 10
    • 0018859134 scopus 로고
    • Neurofibrillary tangles, granulovacuolar degeneration, and neuron loss in Down syndrome: quantitative comparison with Alzheimer dementia
    • Ball M.J., Nuttall K. Neurofibrillary tangles, granulovacuolar degeneration, and neuron loss in Down syndrome: quantitative comparison with Alzheimer dementia. Ann. Neurol. 1980, 7:462-465.
    • (1980) Ann. Neurol. , vol.7 , pp. 462-465
    • Ball, M.J.1    Nuttall, K.2
  • 11
    • 33746406026 scopus 로고    scopus 로고
    • Personality and behaviour changes mark the early stages of Alzheimer's disease in adults with Down's syndrome: findings from a prospective population-based study
    • Ball S.L., Holland A.J., Hon J., Huppert F., Treppner P., Watson P.C. Personality and behaviour changes mark the early stages of Alzheimer's disease in adults with Down's syndrome: findings from a prospective population-based study. Int. J. Geriatr. Psychiatry 2006, 21:661-673.
    • (2006) Int. J. Geriatr. Psychiatry , vol.21 , pp. 661-673
    • Ball, S.L.1    Holland, A.J.2    Hon, J.3    Huppert, F.4    Treppner, P.5    Watson, P.C.6
  • 12
    • 41049084845 scopus 로고    scopus 로고
    • Executive dysfunction and its association with personality and behaviour changes in the development of Alzheimer's disease in adults with Down syndrome and mild to moderate learning disabilities
    • Ball S.L., Holland A.J., Treppner P., Watson P.C., Huppert F.A. Executive dysfunction and its association with personality and behaviour changes in the development of Alzheimer's disease in adults with Down syndrome and mild to moderate learning disabilities. Brit. J. Clin. Psychol. 2008, 47:1-29.
    • (2008) Brit. J. Clin. Psychol. , vol.47 , pp. 1-29
    • Ball, S.L.1    Holland, A.J.2    Treppner, P.3    Watson, P.C.4    Huppert, F.A.5
  • 13
    • 0033037911 scopus 로고    scopus 로고
    • Neuronal apoptosis in mouse trisomy 16: mediation by caspases
    • Bambrick L.L., Krueger B.K. Neuronal apoptosis in mouse trisomy 16: mediation by caspases. J. Neurochem. 1999, 72:1769-1772.
    • (1999) J. Neurochem. , vol.72 , pp. 1769-1772
    • Bambrick, L.L.1    Krueger, B.K.2
  • 14
    • 0038054075 scopus 로고    scopus 로고
    • Altered astrocyte calcium homeostasis and proliferation in theTs65Dn mouse, a model of Down syndrome
    • Bambrick L.L., Yarowsky P.J., Krueger B.K. Altered astrocyte calcium homeostasis and proliferation in theTs65Dn mouse, a model of Down syndrome. J. Neurosci. Res. 2003, 73:89-94.
    • (2003) J. Neurosci. Res. , vol.73 , pp. 89-94
    • Bambrick, L.L.1    Yarowsky, P.J.2    Krueger, B.K.3
  • 15
    • 0019972810 scopus 로고
    • The cholinergic hypothesis of geriatric memory dysfunction
    • Bartus R.T., Dean R.L., Beer B., Lippa A.S. The cholinergic hypothesis of geriatric memory dysfunction. Science 1982, 217:408-414.
    • (1982) Science , vol.217 , pp. 408-414
    • Bartus, R.T.1    Dean, R.L.2    Beer, B.3    Lippa, A.S.4
  • 16
    • 0033978891 scopus 로고    scopus 로고
    • Discovery and genetic localization of Down syndrome cerebellar phenotypes using the Ts65Dn mouse
    • Baxter L.L., Moran T.H., Richtsmeier J.T., Troncoso J., Reeves R.H. Discovery and genetic localization of Down syndrome cerebellar phenotypes using the Ts65Dn mouse. Hum. Mol. Genet. 2000, 9:195-202.
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 195-202
    • Baxter, L.L.1    Moran, T.H.2    Richtsmeier, J.T.3    Troncoso, J.4    Reeves, R.H.5
  • 17
    • 0022506009 scopus 로고
    • Dendritic atrophy in children with Down's syndrome
    • Becker L.E., Armstrong D.L., Chan F. Dendritic atrophy in children with Down's syndrome. Ann. Neurol. 1986, 20:520-526.
    • (1986) Ann. Neurol. , vol.20 , pp. 520-526
    • Becker, L.E.1    Armstrong, D.L.2    Chan, F.3
  • 18
    • 0042829429 scopus 로고    scopus 로고
    • Redox regulation of neuronal migration in a Down syndrome model
    • Behar T.N., Colton C.A. Redox regulation of neuronal migration in a Down syndrome model. Free Radic. Biol. Med. 2003, 35:566-575.
    • (2003) Free Radic. Biol. Med. , vol.35 , pp. 566-575
    • Behar, T.N.1    Colton, C.A.2
  • 19
    • 65949098892 scopus 로고    scopus 로고
    • The " Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome
    • Belichenko P.N., Belichenko P.V., Kleschevnikov A.M., Salehi A., Reeves R.H., Mobley W.C. The " Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome. J. Neurosci. 2009, 29:5938-5948.
    • (2009) J. Neurosci. , vol.29 , pp. 5938-5948
    • Belichenko, P.N.1    Belichenko, P.V.2    Kleschevnikov, A.M.3    Salehi, A.4    Reeves, R.H.5    Mobley, W.C.6
  • 21
    • 34548795562 scopus 로고    scopus 로고
    • Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships
    • Belichenko P.V., Kleschevnikov A.M., Salehi A., Epstein C.J., Mobley W.C. Synaptic and cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype relationships. J. Comp. Neurol. 2007, 504:329-345.
    • (2007) J. Comp. Neurol. , vol.504 , pp. 329-345
    • Belichenko, P.V.1    Kleschevnikov, A.M.2    Salehi, A.3    Epstein, C.J.4    Mobley, W.C.5
  • 25
    • 34347231972 scopus 로고    scopus 로고
    • Synaptic plasticity and the neurobiology of learning and memory
    • Benfenati F. Synaptic plasticity and the neurobiology of learning and memory. Acta Biomed. 2007, 78:58-66.
    • (2007) Acta Biomed. , vol.78 , pp. 58-66
    • Benfenati, F.1
  • 26
    • 0028781954 scopus 로고
    • Dynamics of the CA3 pyramidal neuron autoassociative memory network in the hippocampus
    • Bennett M.R., Gibson W.G., Robinson J. Dynamics of the CA3 pyramidal neuron autoassociative memory network in the hippocampus. Philos. Trans. R. Soc. Lond. B Biol. Sci. 1994, 343:167-187.
    • (1994) Philos. Trans. R. Soc. Lond. B Biol. Sci. , vol.343 , pp. 167-187
    • Bennett, M.R.1    Gibson, W.G.2    Robinson, J.3
  • 27
    • 77952950820 scopus 로고    scopus 로고
    • Abnormal synaptic properties in Down syndrome: lessons from mouse models
    • Best T.K., Siarey R.J., Galdzicki Z. Abnormal synaptic properties in Down syndrome: lessons from mouse models. Cell. Sci. Rev. 2006.
    • (2006) Cell. Sci. Rev.
    • Best, T.K.1    Siarey, R.J.2    Galdzicki, Z.3
  • 28
    • 71549157180 scopus 로고    scopus 로고
    • Lithium restores neurogenesis in the subventricular zone of the Ts65Dn mouse, a model for Down syndrome
    • Bianchi P., Ciani E., Contestabile A., Guidi S., Bartesaghi R. Lithium restores neurogenesis in the subventricular zone of the Ts65Dn mouse, a model for Down syndrome. Brain Pathol. 2009, 10.1111/j.1750-3639.2008.00246.x.
    • (2009) Brain Pathol.
    • Bianchi, P.1    Ciani, E.2    Contestabile, A.3    Guidi, S.4    Bartesaghi, R.5
  • 29
    • 0037450168 scopus 로고    scopus 로고
    • Frontal cortex BDNF levels correlate with working memory in an animal model of Down syndrome
    • Bimonte-Nelson H.A., Hunter C.L., Nelson M.E., Granholm A.C. Frontal cortex BDNF levels correlate with working memory in an animal model of Down syndrome. Behav. Brain Res. 2003, 139:47-57.
    • (2003) Behav. Brain Res. , vol.139 , pp. 47-57
    • Bimonte-Nelson, H.A.1    Hunter, C.L.2    Nelson, M.E.3    Granholm, A.C.4
  • 31
    • 1842483988 scopus 로고    scopus 로고
    • Clinical, social, and ethical implications of changing life expectancy in Down syndrome
    • Bittles A.H., Glasson E.J. Clinical, social, and ethical implications of changing life expectancy in Down syndrome. Dev. Med. Child Neurol. 2004, 46:282-286.
    • (2004) Dev. Med. Child Neurol. , vol.46 , pp. 282-286
    • Bittles, A.H.1    Glasson, E.J.2
  • 33
    • 0014313861 scopus 로고
    • The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects
    • Blessed G., Tomlinson B.E., Roth M. The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. Br. J. Psychiatry 1968, 114:797-811.
    • (1968) Br. J. Psychiatry , vol.114 , pp. 797-811
    • Blessed, G.1    Tomlinson, B.E.2    Roth, M.3
  • 35
    • 0029417023 scopus 로고
    • Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro
    • Busciglio J., Yankner B.A. Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro. Nature 1995, 378:776-779.
    • (1995) Nature , vol.378 , pp. 776-779
    • Busciglio, J.1    Yankner, B.A.2
  • 36
    • 2542519087 scopus 로고    scopus 로고
    • Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone
    • Caillé I., Allinquant B., Dupont E., Bouillot C., Langer A., Müller U., Prochiantz A. Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone. Development 2004, 131:2173-2181.
    • (2004) Development , vol.131 , pp. 2173-2181
    • Caillé, I.1    Allinquant, B.2    Dupont, E.3    Bouillot, C.4    Langer, A.5    Müller, U.6    Prochiantz, A.7
  • 38
    • 0031060636 scopus 로고    scopus 로고
    • Long-term memory in mental retardation: evidence for a specific impairment in subjects with Down's syndrome
    • Carlesimo G.A., Marotta L., Vicari S. Long-term memory in mental retardation: evidence for a specific impairment in subjects with Down's syndrome. Neuropsychologia 1997, 35:71-79.
    • (1997) Neuropsychologia , vol.35 , pp. 71-79
    • Carlesimo, G.A.1    Marotta, L.2    Vicari, S.3
  • 41
    • 35548970343 scopus 로고    scopus 로고
    • Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome
    • Chakrabarti L., Galdzicki Z., Haydar T.F. Defects in embryonic neurogenesis and initial synapse formation in the forebrain of the Ts65Dn mouse model of Down syndrome. J. Neurosci. 2007, 27:11483-11495.
    • (2007) J. Neurosci. , vol.27 , pp. 11483-11495
    • Chakrabarti, L.1    Galdzicki, Z.2    Haydar, T.F.3
  • 42
    • 27644557511 scopus 로고    scopus 로고
    • Drosophila melanogaster homolog of Down syndrome critical region 1 is critical for mitochondrial function
    • Chang K.T., Min K.T. Drosophila melanogaster homolog of Down syndrome critical region 1 is critical for mitochondrial function. Nat. Neurosci. 2005, 8:1577-1585.
    • (2005) Nat. Neurosci. , vol.8 , pp. 1577-1585
    • Chang, K.T.1    Min, K.T.2
  • 43
    • 36849017423 scopus 로고    scopus 로고
    • Age-related changes in memory and in acetylcholine functions in the hippocampus in the Ts65Dn mouse, a model of Down syndrome
    • Chang Q., Gold P.E. Age-related changes in memory and in acetylcholine functions in the hippocampus in the Ts65Dn mouse, a model of Down syndrome. Neurobiol. Learn. Mem. 2008, 89:167-177.
    • (2008) Neurobiol. Learn. Mem. , vol.89 , pp. 167-177
    • Chang, Q.1    Gold, P.E.2
  • 45
    • 30944465646 scopus 로고    scopus 로고
    • The amyloid precursor protein and postnatal neurogenesis/neuroregeneration
    • Chen Y., Tang B.L. The amyloid precursor protein and postnatal neurogenesis/neuroregeneration. Biochem. Biophys. Res. Commun. 2006, 341:1-5.
    • (2006) Biochem. Biophys. Res. Commun. , vol.341 , pp. 1-5
    • Chen, Y.1    Tang, B.L.2
  • 46
    • 17444397425 scopus 로고    scopus 로고
    • Concurrent generation of subplate and cortical plate neurons in developing trisomy 16 mouse cortex
    • Cheng A., Haydar T.F., Yarowsky P.J., Krueger B.K. Concurrent generation of subplate and cortical plate neurons in developing trisomy 16 mouse cortex. Dev. Neurosci. 2004, 26:255-265.
    • (2004) Dev. Neurosci. , vol.26 , pp. 255-265
    • Cheng, A.1    Haydar, T.F.2    Yarowsky, P.J.3    Krueger, B.K.4
  • 48
    • 0037320372 scopus 로고    scopus 로고
    • Donepezil use in the treatment of dementia associated with Down syndrome
    • Cipriani G., Bianchetti A., Trabucchi M. Donepezil use in the treatment of dementia associated with Down syndrome. Arch. Neurol. 2003, 60:292.
    • (2003) Arch. Neurol. , vol.60 , pp. 292
    • Cipriani, G.1    Bianchetti, A.2    Trabucchi, M.3
  • 49
    • 0042823394 scopus 로고    scopus 로고
    • Behavioral assessment of children with Down syndrome using the Reiss psychopathology scale
    • Clark D., Wilson G.N. Behavioral assessment of children with Down syndrome using the Reiss psychopathology scale. Am. J. Med. Genet. 2003, 118:210-216.
    • (2003) Am. J. Med. Genet. , vol.118 , pp. 210-216
    • Clark, D.1    Wilson, G.N.2
  • 50
    • 33746047443 scopus 로고    scopus 로고
    • Fluoxetine rescues deficient neurogenesis in hippocampus of the Ts65Dn mouse model for Down syndrome
    • Clark S., Schwalbe J., Stasko M.R., Yarowsky P.J., Costa A.C. Fluoxetine rescues deficient neurogenesis in hippocampus of the Ts65Dn mouse model for Down syndrome. Exp. Neurol. 2006, 200:256-261.
    • (2006) Exp. Neurol. , vol.200 , pp. 256-261
    • Clark, S.1    Schwalbe, J.2    Stasko, M.R.3    Yarowsky, P.J.4    Costa, A.C.5
  • 51
    • 0011069450 scopus 로고
    • The structure of cerebral cortex in Down syndrome
    • Colon E. The structure of cerebral cortex in Down syndrome. Neuropediatrie 1972, 3:362-376.
    • (1972) Neuropediatrie , vol.3 , pp. 362-376
    • Colon, E.1
  • 52
    • 38349154106 scopus 로고    scopus 로고
    • The place of choline acetyltransferase activity measurement in the " cholinergic hypothesis" of neurodegenerative diseases
    • Contestabile A., Ciani E., Contestabile A. The place of choline acetyltransferase activity measurement in the " cholinergic hypothesis" of neurodegenerative diseases. Neurochem. Res. 2008, 33:318-327.
    • (2008) Neurochem. Res. , vol.33 , pp. 318-327
    • Contestabile, A.1    Ciani, E.2    Contestabile, A.3
  • 53
    • 61649106285 scopus 로고    scopus 로고
    • Cell cycle elongation impairs proliferation of cerebellar granule cell precursors in the Ts65Dn mouse, an animal model for Down syndrome
    • Contestabile A., Fila T., Bartesaghi R., Ciani E. Cell cycle elongation impairs proliferation of cerebellar granule cell precursors in the Ts65Dn mouse, an animal model for Down syndrome. Brain pathol. 2009, 19:224-237.
    • (2009) Brain pathol. , vol.19 , pp. 224-237
    • Contestabile, A.1    Fila, T.2    Bartesaghi, R.3    Ciani, E.4
  • 54
    • 33645323789 scopus 로고    scopus 로고
    • Choline acetyltransferase activity at different ages in brain of Ts65Dn mice, an animal model for Down's syndrome and related neurodegenerative diseases
    • Contestabile A., Fila T., Bartesaghi R., Contestabile A., Ciani E. Choline acetyltransferase activity at different ages in brain of Ts65Dn mice, an animal model for Down's syndrome and related neurodegenerative diseases. J. Neurochem. 2006, 97:515-526.
    • (2006) J. Neurochem. , vol.97 , pp. 515-526
    • Contestabile, A.1    Fila, T.2    Bartesaghi, R.3    Contestabile, A.4    Ciani, E.5
  • 55
    • 62449201452 scopus 로고    scopus 로고
    • Widespread impairment of cell proliferation in the neonate Ts65Dn mouse, a model for Down syndrome
    • Contestabile A., Fila T., Cappellini A., Bartesaghi R., Ciani E. Widespread impairment of cell proliferation in the neonate Ts65Dn mouse, a model for Down syndrome. Cell Prolif. 2009, 42:171-181.
    • (2009) Cell Prolif. , vol.42 , pp. 171-181
    • Contestabile, A.1    Fila, T.2    Cappellini, A.3    Bartesaghi, R.4    Ciani, E.5
  • 56
    • 34548102066 scopus 로고    scopus 로고
    • Cell cycle alteration and decreased cell proliferation in the hippocampal dentate gyrus and in the neocortical germinal matrix of fetuses with Down syndrome and in Ts65Dn mice
    • Contestabile A., Fila T., Ceccarelli C., Bonasone P., Bonapace L., Santini D., Bartesaghi R., Ciani E. Cell cycle alteration and decreased cell proliferation in the hippocampal dentate gyrus and in the neocortical germinal matrix of fetuses with Down syndrome and in Ts65Dn mice. Hippocampus 2007, 17:665-678.
    • (2007) Hippocampus , vol.17 , pp. 665-678
    • Contestabile, A.1    Fila, T.2    Ceccarelli, C.3    Bonasone, P.4    Bonapace, L.5    Santini, D.6    Bartesaghi, R.7    Ciani, E.8
  • 57
    • 13144256746 scopus 로고    scopus 로고
    • Controlling neural stem cell division within the adult subventricular zone: an APPealing job
    • Conti L., Cattaneo E. Controlling neural stem cell division within the adult subventricular zone: an APPealing job. Trends Neurosci. 2005, 28:57-59.
    • (2005) Trends Neurosci. , vol.28 , pp. 57-59
    • Conti, L.1    Cattaneo, E.2
  • 60
    • 0025972390 scopus 로고
    • Nerve growth factor corrects developmental impairments of basal forebrain cholinergic neurons in the trisomy 16 mouse
    • Corsi P., Coyle J.T. Nerve growth factor corrects developmental impairments of basal forebrain cholinergic neurons in the trisomy 16 mouse. Proc. Natl. Acad. Sci. U.S.A. 1991, 88:1793-1797.
    • (1991) Proc. Natl. Acad. Sci. U.S.A. , vol.88 , pp. 1793-1797
    • Corsi, P.1    Coyle, J.T.2
  • 61
    • 19544393555 scopus 로고    scopus 로고
    • Deficits in hippocampal CA1 LTP induced by TBS but not HFS in the Ts65Dn mouse: a model of Down syndrome
    • Costa A.C., Grybko M.J. Deficits in hippocampal CA1 LTP induced by TBS but not HFS in the Ts65Dn mouse: a model of Down syndrome. Neurosci. Lett. 2005, 382:317-322.
    • (2005) Neurosci. Lett. , vol.382 , pp. 317-322
    • Costa, A.C.1    Grybko, M.J.2
  • 62
    • 0033407499 scopus 로고    scopus 로고
    • Motor dysfunction in a mouse model for Down syndrome
    • Costa A.C., Walsh K., Davisson M.T. Motor dysfunction in a mouse model for Down syndrome. Physiol. Behav. 1999, 68:211-220.
    • (1999) Physiol. Behav. , vol.68 , pp. 211-220
    • Costa, A.C.1    Walsh, K.2    Davisson, M.T.3
  • 63
    • 43649094588 scopus 로고    scopus 로고
    • Acute Injections of the NMDA receptor antagonist memantine rescue performance deficits of the Ts65Dn mouse model of Down syndrome on a fear conditioning test
    • Costa C.S.A., Scott-McKean J.J., Stasko M.R. Acute Injections of the NMDA receptor antagonist memantine rescue performance deficits of the Ts65Dn mouse model of Down syndrome on a fear conditioning test. Neuropsychopharmacology 2007, 33:1624-1632.
    • (2007) Neuropsychopharmacology , vol.33 , pp. 1624-1632
    • Costa, C.S.A.1    Scott-McKean, J.J.2    Stasko, M.R.3
  • 66
    • 0031172775 scopus 로고    scopus 로고
    • Hamster adapt78 mRNA is a Down syndrome critical region homologue that is inducible by oxidative stress
    • Crawford D.R., Leahy K.P., Abramova N., Lan L., Wang Y., Davies K.J. Hamster adapt78 mRNA is a Down syndrome critical region homologue that is inducible by oxidative stress. Arch. Biochem. Biophys. 1997, 342:6-12.
    • (1997) Arch. Biochem. Biophys. , vol.342 , pp. 6-12
    • Crawford, D.R.1    Leahy, K.P.2    Abramova, N.3    Lan, L.4    Wang, Y.5    Davies, K.J.6
  • 67
    • 0002120011 scopus 로고
    • A statistical note on cerebellar and brain stem weight in Mongolism
    • Crome L., Cowie V., Slater E. A statistical note on cerebellar and brain stem weight in Mongolism. J. Ment. Defic. Res. 1966, 10:69-72.
    • (1966) J. Ment. Defic. Res. , vol.10 , pp. 69-72
    • Crome, L.1    Cowie, V.2    Slater, E.3
  • 68
  • 70
    • 0011162190 scopus 로고
    • Selective loss of central cholinergic neurons in Alzheimer's disease
    • Davies P., Maloney A.J.F. Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet 1976, 2:1403.
    • (1976) Lancet , vol.2 , pp. 1403
    • Davies, P.1    Maloney, A.J.F.2
  • 71
    • 0025663975 scopus 로고
    • Segmental trisomy of murine chromosome 16: a new model system for studying Down syndrome
    • Davisson M.T., Schmidt C., Akeson E.C. Segmental trisomy of murine chromosome 16: a new model system for studying Down syndrome. Prog. Clin. Biol. Res. 1990, 360:263-280.
    • (1990) Prog. Clin. Biol. Res. , vol.360 , pp. 263-280
    • Davisson, M.T.1    Schmidt, C.2    Akeson, E.C.3
  • 72
    • 0030068056 scopus 로고    scopus 로고
    • Elevation in the ratio of Cu/Zn-superoxide dismutase to glutathione peroxidase activity induces features of cellular senescence and this effect is mediated by hydrogen peroxide
    • de Haan J.B., Cristiano F., Iannello R., Bladier C., Kelner M.J., Kola I. Elevation in the ratio of Cu/Zn-superoxide dismutase to glutathione peroxidase activity induces features of cellular senescence and this effect is mediated by hydrogen peroxide. Hum. Mol. Genet. 1996, 5:283-292.
    • (1996) Hum. Mol. Genet. , vol.5 , pp. 283-292
    • de Haan, J.B.1    Cristiano, F.2    Iannello, R.3    Bladier, C.4    Kelner, M.J.5    Kola, I.6
  • 73
    • 34248153904 scopus 로고    scopus 로고
    • Symptoms of dementia among adults with Down's syndrome: a qualitative study
    • Deb S., Hare M., Prior L. Symptoms of dementia among adults with Down's syndrome: a qualitative study. J. Intellect. Disabil. Res. 2007, 51:726-739.
    • (2007) J. Intellect. Disabil. Res. , vol.51 , pp. 726-739
    • Deb, S.1    Hare, M.2    Prior, L.3
  • 74
    • 34548379972 scopus 로고    scopus 로고
    • Developmental defects in Trisomy 21 and mouse models
    • Delabar J.M., Aflalo-Rattenbach R., Créau N. Developmental defects in Trisomy 21 and mouse models. Sci.World J. 2006, 1:1945-1964.
    • (2006) Sci.World J. , vol.1 , pp. 1945-1964
    • Delabar, J.M.1    Aflalo-Rattenbach, R.2    Créau, N.3
  • 77
    • 0031890117 scopus 로고    scopus 로고
    • Impaired spatial working and reference memory in segmental trisomy (Ts65Dn) mice
    • Demas G.E., Nelson R.J., Krueger B.K., Yarowsky P.J. Impaired spatial working and reference memory in segmental trisomy (Ts65Dn) mice. Behav. Brain Res. 1998, 90:199-201.
    • (1998) Behav. Brain Res. , vol.90 , pp. 199-201
    • Demas, G.E.1    Nelson, R.J.2    Krueger, B.K.3    Yarowsky, P.J.4
  • 81
    • 0037662885 scopus 로고    scopus 로고
    • Alterations of neocortical pyramidal cell phenotype in the Ts65Dn mouse model of Down syndrome: effects of environmental enrichment
    • Dierssen M., Benavides-Piccione R., Martinez-Cue C., Estivill X., Florez J., Elston G.N., DeFelipe J. Alterations of neocortical pyramidal cell phenotype in the Ts65Dn mouse model of Down syndrome: effects of environmental enrichment. Cereb. Cortex 2003, 13:758-764.
    • (2003) Cereb. Cortex , vol.13 , pp. 758-764
    • Dierssen, M.1    Benavides-Piccione, R.2    Martinez-Cue, C.3    Estivill, X.4    Florez, J.5    Elston, G.N.6    DeFelipe, J.7
  • 82
    • 0000922691 scopus 로고
    • Observations on an ethnic classification of idiots
    • Down J.L.H. Observations on an ethnic classification of idiots. Clin. Lect. Reports, London Hospital 1866, 3:259-262.
    • (1866) Clin. Lect. Reports, London Hospital , vol.3 , pp. 259-262
    • Down, J.L.H.1
  • 83
    • 0040576089 scopus 로고
    • Sensorimotor development of infants with Down syndrome
    • Cambridge University Press, New York, D. Cicchetti, M. Beeghly (Eds.)
    • Dunst C.J. Sensorimotor development of infants with Down syndrome. Children with Down Syndrome 1990, 180-230. Cambridge University Press, New York. D. Cicchetti, M. Beeghly (Eds.).
    • (1990) Children with Down Syndrome , pp. 180-230
    • Dunst, C.J.1
  • 84
    • 0024556142 scopus 로고
    • Memory for spatial location in children, adults, and mentally retarded persons
    • Ellis N.R., Woodley-Zanthos P., Dulaney C.L. Memory for spatial location in children, adults, and mentally retarded persons. Am. J. Ment. Retard. 1989, 93:521-526.
    • (1989) Am. J. Ment. Retard. , vol.93 , pp. 521-526
    • Ellis, N.R.1    Woodley-Zanthos, P.2    Dulaney, C.L.3
  • 85
    • 0037339732 scopus 로고    scopus 로고
    • Molecular changes in fetal Down syndrome brain
    • Engidawork E., Lubec G. Molecular changes in fetal Down syndrome brain. J. Neurochem. 2003, 84:895-904.
    • (2003) J. Neurochem. , vol.84 , pp. 895-904
    • Engidawork, E.1    Lubec, G.2
  • 86
    • 0022271552 scopus 로고
    • Mouse trisomy 16: an animal model of human trisomy 21 (Down syndrome)
    • Epstein C.J., Cox D.R., Epstein L.B. Mouse trisomy 16: an animal model of human trisomy 21 (Down syndrome). Ann. N. Y. Acad. Sci. 1985, 450:157-168.
    • (1985) Ann. N. Y. Acad. Sci. , vol.450 , pp. 157-168
    • Epstein, C.J.1    Cox, D.R.2    Epstein, L.B.3
  • 88
    • 0037257555 scopus 로고    scopus 로고
    • DSCR1(Adapt78)-a Janus gene providing stress protection but causing Alzheimer's disease?
    • Ermak G., Davies K.J. DSCR1(Adapt78)-a Janus gene providing stress protection but causing Alzheimer's disease?. IUBMB Life 2003, 55:29-31.
    • (2003) IUBMB Life , vol.55 , pp. 29-31
    • Ermak, G.1    Davies, K.J.2
  • 89
    • 0036277167 scopus 로고    scopus 로고
    • The DSCR1 (Adapt78) isoform 1 protein calcipressin 1 inhibits calcineurin and protects against acute calcium-mediated stress damage, including transient oxidative stress
    • Ermak G., Harris C.D., Davies K.J. The DSCR1 (Adapt78) isoform 1 protein calcipressin 1 inhibits calcineurin and protects against acute calcium-mediated stress damage, including transient oxidative stress. FASEB J. 2002, 16:814-824.
    • (2002) FASEB J. , vol.16 , pp. 814-824
    • Ermak, G.1    Harris, C.D.2    Davies, K.J.3
  • 90
    • 0035914413 scopus 로고    scopus 로고
    • Chronic overexpression of the calcineurin inhibitory gene DSCR1 (Adapt78) is associated with Alzheimer's disease
    • Ermak G., Morgan T.E., Davies K.J. Chronic overexpression of the calcineurin inhibitory gene DSCR1 (Adapt78) is associated with Alzheimer's disease. J. Biol. Chem. 2001, 276:38787-38794.
    • (2001) J. Biol. Chem. , vol.276 , pp. 38787-38794
    • Ermak, G.1    Morgan, T.E.2    Davies, K.J.3
  • 94
    • 38749133061 scopus 로고    scopus 로고
    • Episodic-like memory in Ts65Dn, a mouse model of Down syndrome
    • Fernandez F., Garner C.C. Episodic-like memory in Ts65Dn, a mouse model of Down syndrome. Behav. Brain Res. 2008, 188:233-237.
    • (2008) Behav. Brain Res. , vol.188 , pp. 233-237
    • Fernandez, F.1    Garner, C.C.2
  • 96
    • 0025296344 scopus 로고
    • Down's syndrome and Alzheimer's disease: dendritic spine counts in hippocampus
    • Ferrer I., Gullotta F. Down's syndrome and Alzheimer's disease: dendritic spine counts in hippocampus. Acta Neuropathol. 1990, 79:680-685.
    • (1990) Acta Neuropathol. , vol.79 , pp. 680-685
    • Ferrer, I.1    Gullotta, F.2
  • 97
    • 0027953818 scopus 로고
    • Regional alteration of cholinergic function in central neurons of trisomy 16 mouse fetuses, an animal model of human trisomy 21 (Down syndrome)
    • Fiedler J.L., Epstein C.J., Rapoport S.I., Caviedes R., Caviedes P. Regional alteration of cholinergic function in central neurons of trisomy 16 mouse fetuses, an animal model of human trisomy 21 (Down syndrome). Brain Res. 1994, 658:27-32.
    • (1994) Brain Res. , vol.658 , pp. 27-32
    • Fiedler, J.L.1    Epstein, C.J.2    Rapoport, S.I.3    Caviedes, R.4    Caviedes, P.5
  • 99
    • 0029072567 scopus 로고
    • Modulation of the phosphorylation state of tau in situ: the roles of calcium and cyclic AMP
    • Fleming L.M., Johnson G.V. Modulation of the phosphorylation state of tau in situ: the roles of calcium and cyclic AMP. Biochem. J. 1995, 309:41-47.
    • (1995) Biochem. J. , vol.309 , pp. 41-47
    • Fleming, L.M.1    Johnson, G.V.2
  • 102
    • 0001885609 scopus 로고
    • The course of lamguage learning in children with Down syndrome: Longitudinal and language level comparisons with young normally developing children
    • Erlbaum, Hillsdale, NJ, H. Tager-Flusberg (Ed.)
    • Fowler A.E., Gelman R., Gleitman L.R. The course of lamguage learning in children with Down syndrome: Longitudinal and language level comparisons with young normally developing children. Constraints of Language Acquisition 1994, 91-140. Erlbaum, Hillsdale, NJ. H. Tager-Flusberg (Ed.).
    • (1994) Constraints of Language Acquisition , pp. 91-140
    • Fowler, A.E.1    Gelman, R.2    Gleitman, L.R.3
  • 104
  • 105
    • 0042025826 scopus 로고    scopus 로고
    • Understanding mental retardation in Down's syndrome using trisomy 16 mouse models
    • Galdzicki Z., Siarey R.J. Understanding mental retardation in Down's syndrome using trisomy 16 mouse models. Genes Brain Behav. 2003, 2:167-178.
    • (2003) Genes Brain Behav. , vol.2 , pp. 167-178
    • Galdzicki, Z.1    Siarey, R.J.2
  • 106
    • 1542634742 scopus 로고    scopus 로고
    • Predicting pathway perturbations in Down syndrome
    • Gardiner K. Predicting pathway perturbations in Down syndrome. J. Neural. Transm. Suppl. 2003, 21-37.
    • (2003) J. Neural. Transm. Suppl. , pp. 21-37
    • Gardiner, K.1
  • 107
    • 0242348738 scopus 로고    scopus 로고
    • Mouse models of Down syndrome: how useful can they be? Comparison of the gene content of human chromosome 21 with orthologous mouse genomic regions
    • Gardiner K., Fortna A., Bechtel L., Davisson M.T. Mouse models of Down syndrome: how useful can they be? Comparison of the gene content of human chromosome 21 with orthologous mouse genomic regions. Gene 2003, 318:137-147.
    • (2003) Gene , vol.318 , pp. 137-147
    • Gardiner, K.1    Fortna, A.2    Bechtel, L.3    Davisson, M.T.4
  • 108
    • 44749089401 scopus 로고    scopus 로고
    • Beta-amyloid and glutamate receptors
    • Gasparini L., Dityatev A. Beta-amyloid and glutamate receptors. Exp. Neurol. 2008, 212:1-4.
    • (2008) Exp. Neurol. , vol.212 , pp. 1-4
    • Gasparini, L.1    Dityatev, A.2
  • 109
    • 77952950426 scopus 로고    scopus 로고
    • Molecular neuropathology in familial and sporadic frontotemporal dementia
    • Cambridge University Press, Cambridge, H. J.R. (Ed.)
    • Gasparini L., Spillantini M.G. Molecular neuropathology in familial and sporadic frontotemporal dementia. Frontotemporal Dementia Syndromes 2007, Cambridge University Press, Cambridge. H. J.R. (Ed.).
    • (2007) Frontotemporal Dementia Syndromes
    • Gasparini, L.1    Spillantini, M.G.2
  • 112
    • 0021207461 scopus 로고
    • Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein
    • Glenner G.G., Wong C.W. Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein. Biochem. Biophys. Res. Commun. 1984, 122:1131-1135.
    • (1984) Biochem. Biophys. Res. Commun. , vol.122 , pp. 1131-1135
    • Glenner, G.G.1    Wong, C.W.2
  • 113
    • 0021256895 scopus 로고
    • Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein
    • Glenner G.G., Wong C.W. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem. Biophys. Res. Commun. 1984, 120:885-890.
    • (1984) Biochem. Biophys. Res. Commun. , vol.120 , pp. 885-890
    • Glenner, G.G.1    Wong, C.W.2
  • 115
    • 0028070918 scopus 로고
    • Development of the superior temporal neocortex is anomalous in trisomy 21
    • Golden J.A., Hyman B.T. Development of the superior temporal neocortex is anomalous in trisomy 21. J. Neuropathol. Exp. Neurol. 1994, 53:513-520.
    • (1994) J. Neuropathol. Exp. Neurol. , vol.53 , pp. 513-520
    • Golden, J.A.1    Hyman, B.T.2
  • 116
    • 0031928291 scopus 로고    scopus 로고
    • The cells and molecules that make a cerebellum
    • Goldowitz D., Hamre K. The cells and molecules that make a cerebellum. Trends Neurosci. 1998, 21:375-382.
    • (1998) Trends Neurosci. , vol.21 , pp. 375-382
    • Goldowitz, D.1    Hamre, K.2
  • 117
    • 0030602070 scopus 로고    scopus 로고
    • Inhibition of protein phosphatase-2B (calcineurin) activity towards Alzheimer abnormally phosphorylated tau by neuroleptics
    • Gong C.X., Shaikh S., Grundke-Iqbal I., Iqbal K. Inhibition of protein phosphatase-2B (calcineurin) activity towards Alzheimer abnormally phosphorylated tau by neuroleptics. Brain Res. 1996, 741:95-102.
    • (1996) Brain Res. , vol.741 , pp. 95-102
    • Gong, C.X.1    Shaikh, S.2    Grundke-Iqbal, I.3    Iqbal, K.4
  • 118
    • 0035943436 scopus 로고    scopus 로고
    • Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils
    • Götz J., Chen F., van Dorpe J., Nitsch R.M. Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils. Science 2001, 293:1491-1495.
    • (2001) Science , vol.293 , pp. 1491-1495
    • Götz, J.1    Chen, F.2    van Dorpe, J.3    Nitsch, R.M.4
  • 121
    • 0034097607 scopus 로고    scopus 로고
    • Loss of cholinergic phenotype in basal forebrain coincides with cognitive decline in a mouse model of Down's syndrome
    • Granholm A.C., Sanders L.A., Crnic L.S. Loss of cholinergic phenotype in basal forebrain coincides with cognitive decline in a mouse model of Down's syndrome. Exp. Neurol. 2000, 161:647-663.
    • (2000) Exp. Neurol. , vol.161 , pp. 647-663
    • Granholm, A.C.1    Sanders, L.A.2    Crnic, L.S.3
  • 122
    • 0029657950 scopus 로고    scopus 로고
    • Clinical features of frontal lobe dementia in comparison to Alzheimer's disease
    • Gregory C.A., Hodges J.R. Clinical features of frontal lobe dementia in comparison to Alzheimer's disease. J. Neural Transm. Suppl. 1996, 47:103-123.
    • (1996) J. Neural Transm. Suppl. , vol.47 , pp. 103-123
    • Gregory, C.A.1    Hodges, J.R.2
  • 123
    • 41149164894 scopus 로고    scopus 로고
    • Neurogenesis impairment and increased cell death reduce total neuron number in the hippocampal region of fetuses with Down syndrome
    • Guidi S., Bonasoni P., Caccarelli C., Santini D., Gualtieri F., Ciani E., Bartesaghi R. Neurogenesis impairment and increased cell death reduce total neuron number in the hippocampal region of fetuses with Down syndrome. Brain Phatol. 2008, 18:180-197.
    • (2008) Brain Phatol. , vol.18 , pp. 180-197
    • Guidi, S.1    Bonasoni, P.2    Caccarelli, C.3    Santini, D.4    Gualtieri, F.5    Ciani, E.6    Bartesaghi, R.7
  • 125
    • 0035144524 scopus 로고    scopus 로고
    • Superoxide dismutase SOD1, encoded on chromosome 21, but not SOD2 is overexpressed in brains of patients with Down syndrome
    • Gulesserian T., Seidl R., Hardmeier R., Cairns N., Lubec G. Superoxide dismutase SOD1, encoded on chromosome 21, but not SOD2 is overexpressed in brains of patients with Down syndrome. J. Investig. Med. 2001, 49:41-46.
    • (2001) J. Investig. Med. , vol.49 , pp. 41-46
    • Gulesserian, T.1    Seidl, R.2    Hardmeier, R.3    Cairns, N.4    Lubec, G.5
  • 127
    • 0344544175 scopus 로고
    • Delayed ontogenesis in human trisomy syndromes
    • Hall B. Delayed ontogenesis in human trisomy syndromes. Hereditas 1965, 52:334-344.
    • (1965) Hereditas , vol.52 , pp. 334-344
    • Hall, B.1
  • 128
    • 0038391317 scopus 로고    scopus 로고
    • Expression patterns and subcellular localization of the Down syndrome candidate protein MNB/DYRK1A suggest a role in late neuronal differentiation
    • Hammerle B., Carnicero A., Elizalde C., Ceron J., Martinez S., Tejedor F.J. Expression patterns and subcellular localization of the Down syndrome candidate protein MNB/DYRK1A suggest a role in late neuronal differentiation. Eur. J. Neurosci. 2003, 17:2277-2286.
    • (2003) Eur. J. Neurosci. , vol.17 , pp. 2277-2286
    • Hammerle, B.1    Carnicero, A.2    Elizalde, C.3    Ceron, J.4    Martinez, S.5    Tejedor, F.J.6
  • 129
    • 0036063617 scopus 로고    scopus 로고
    • Mnb/Dyrk1A is transiently expressed and asymmetrically segregated in neural progenitor cells at the transition to neurogenic divisions
    • Hammerle B., Vera-Samper E., Speicher S., Arencibia R., Martínez S., Tejedor F.J. Mnb/Dyrk1A is transiently expressed and asymmetrically segregated in neural progenitor cells at the transition to neurogenic divisions. Dev. Biol. 2002, 246:259-273.
    • (2002) Dev. Biol. , vol.246 , pp. 259-273
    • Hammerle, B.1    Vera-Samper, E.2    Speicher, S.3    Arencibia, R.4    Martínez, S.5    Tejedor, F.J.6
  • 130
    • 33846986326 scopus 로고    scopus 로고
    • The functional nature of synaptic circuitry is altered in area CA3 of the hippocampus in a mouse model of Down's syndrome
    • Hanson J.E., Blank M., Valenzuela R.A., Garner C.C., Madison D.V. The functional nature of synaptic circuitry is altered in area CA3 of the hippocampus in a mouse model of Down's syndrome. J. Physiol. 2007, 579:53-67.
    • (2007) J. Physiol. , vol.579 , pp. 53-67
    • Hanson, J.E.1    Blank, M.2    Valenzuela, R.A.3    Garner, C.C.4    Madison, D.V.5
  • 131
    • 29144484163 scopus 로고    scopus 로고
    • Multiple roles of the DSCR1 (Adapt78 or RCAN1) gene and its protein product Calcipressin 1 (or RCAN1) in disease
    • Harris C.D., Ermak G., Davies K.J. Multiple roles of the DSCR1 (Adapt78 or RCAN1) gene and its protein product Calcipressin 1 (or RCAN1) in disease. Cell Mol. Life Sci. 2005, 62:2477-2486.
    • (2005) Cell Mol. Life Sci. , vol.62 , pp. 2477-2486
    • Harris, C.D.1    Ermak, G.2    Davies, K.J.3
  • 132
    • 0035319804 scopus 로고    scopus 로고
    • To err (meiotically) is human: the genesis of human aneuploidy
    • Hassold T., Hunt P. To err (meiotically) is human: the genesis of human aneuploidy. Nat. Rev. Genet. 2001, 2:280-291.
    • (2001) Nat. Rev. Genet. , vol.2 , pp. 280-291
    • Hassold, T.1    Hunt, P.2
  • 134
    • 0029813783 scopus 로고    scopus 로고
    • Consequences of trisomy 16 for mouse brain development: corticogenesis in a model of Down syndrome
    • Haydar T.F., Blue M.E., Molliver M.E., Krueger B.K., Yarowsky P.J. Consequences of trisomy 16 for mouse brain development: corticogenesis in a model of Down syndrome. J. Neurosci. 1996, 16:6175-6182.
    • (1996) J. Neurosci. , vol.16 , pp. 6175-6182
    • Haydar, T.F.1    Blue, M.E.2    Molliver, M.E.3    Krueger, B.K.4    Yarowsky, P.J.5
  • 135
    • 0034214395 scopus 로고    scopus 로고
    • Role of founder cell deficit and delayed neuronogenesis in microencephaly of the trisomy 16 mouse
    • Haydar T.F., Nowakowski R.S., Yarowsky P.J., Krueger B.K. Role of founder cell deficit and delayed neuronogenesis in microencephaly of the trisomy 16 mouse. J. Neurosci. 2000, 20:4156-4164.
    • (2000) J. Neurosci. , vol.20 , pp. 4156-4164
    • Haydar, T.F.1    Nowakowski, R.S.2    Yarowsky, P.J.3    Krueger, B.K.4
  • 137
    • 0032865918 scopus 로고    scopus 로고
    • Adverse effects of donepezil in treating Alzheimer's disease associated with Down's syndrome
    • Hemingway-Eltomey J.M., Lerner A.J. Adverse effects of donepezil in treating Alzheimer's disease associated with Down's syndrome. Am. J. Psychiatry 1999, 159:1470.
    • (1999) Am. J. Psychiatry , vol.159 , pp. 1470
    • Hemingway-Eltomey, J.M.1    Lerner, A.J.2
  • 138
    • 0028948391 scopus 로고
    • Age-related distribution of neuropathologic changes in the cerebral cortex of patients with Down's syndrome. Quantitative regional analysis and comparison with Alzheimer's disease
    • Hof P.R., Bouras C., Perl D.P., Sparks D.L., Mehta N., Morrison J.H. Age-related distribution of neuropathologic changes in the cerebral cortex of patients with Down's syndrome. Quantitative regional analysis and comparison with Alzheimer's disease. Arch. Neurol. 1995, 52:379-391.
    • (1995) Arch. Neurol. , vol.52 , pp. 379-391
    • Hof, P.R.1    Bouras, C.2    Perl, D.P.3    Sparks, D.L.4    Mehta, N.5    Morrison, J.H.6
  • 139
    • 0034125007 scopus 로고    scopus 로고
    • Incidence and course of dementia in people with Down's syndrome: findings from a population-based study
    • Holland A.J., Hon J., Huppert F.A., Stevens F. Incidence and course of dementia in people with Down's syndrome: findings from a population-based study. J. Intellect. Disabil. Res. 2000, 44:138-146.
    • (2000) J. Intellect. Disabil. Res. , vol.44 , pp. 138-146
    • Holland, A.J.1    Hon, J.2    Huppert, F.A.3    Stevens, F.4
  • 140
    • 0031806441 scopus 로고    scopus 로고
    • Population-based study of the prevalence and presentation of dementia in adults with Down's syndrome
    • Holland A.J., Hon J., Huppert F.A., Stevens F., Watson P. Population-based study of the prevalence and presentation of dementia in adults with Down's syndrome. Br. J. Psychiatry 1998, 172.
    • (1998) Br. J. Psychiatry , vol.172
    • Holland, A.J.1    Hon, J.2    Huppert, F.A.3    Stevens, F.4    Watson, P.5
  • 142
    • 0002232454 scopus 로고    scopus 로고
    • Johns Hopkins Univ. Press, Baltimore, A. Milunsky (Ed.)
    • Hsu L.Y. Genetic Disorders and the Fetus 1998, 179-248. Johns Hopkins Univ. Press, Baltimore. A. Milunsky (Ed.).
    • (1998) Genetic Disorders and the Fetus , pp. 179-248
    • Hsu, L.Y.1
  • 145
    • 9144267928 scopus 로고    scopus 로고
    • Minocycline prevents cholinergic loss in a mouse model of Down's syndrome
    • Hunter C.L., Bachman D., Granholm A.C. Minocycline prevents cholinergic loss in a mouse model of Down's syndrome. Ann. Neurol. 2004, 56:675-688.
    • (2004) Ann. Neurol. , vol.56 , pp. 675-688
    • Hunter, C.L.1    Bachman, D.2    Granholm, A.C.3
  • 146
    • 3042521332 scopus 로고    scopus 로고
    • Behavioral and neurobiological markers of Alzheimer's disease in Ts65Dn mice: effects of estrogen
    • Hunter C.L., Bimonte-Nelson H.A., Nelson M., EcKman C.B., Granholm A.C. Behavioral and neurobiological markers of Alzheimer's disease in Ts65Dn mice: effects of estrogen. Neurobiol. Aging. 2004, 25:873-884.
    • (2004) Neurobiol. Aging. , vol.25 , pp. 873-884
    • Hunter, C.L.1    Bimonte-Nelson, H.A.2    Nelson, M.3    EcKman, C.B.4    Granholm, A.C.5
  • 147
    • 0037460101 scopus 로고    scopus 로고
    • Behavioral comparison of 4 and 6-month-old Ts65Dn mice: age-related impairments in working and reference memory
    • Hunter C.L., Bimonte H.A., Granholm A.C. Behavioral comparison of 4 and 6-month-old Ts65Dn mice: age-related impairments in working and reference memory. Behav. Brain Res. 2003, 138:121-131.
    • (2003) Behav. Brain Res. , vol.138 , pp. 121-131
    • Hunter, C.L.1    Bimonte, H.A.2    Granholm, A.C.3
  • 148
    • 0035208315 scopus 로고    scopus 로고
    • Age-related deficits in context discrimination learning in Ts65Dn mice that model Down syndrome and Alzheimer's disease
    • Hyde L.A., Crnic L.S. Age-related deficits in context discrimination learning in Ts65Dn mice that model Down syndrome and Alzheimer's disease. Behav. Neurosci. 2001, 115:1239-1246.
    • (2001) Behav. Neurosci. , vol.115 , pp. 1239-1246
    • Hyde, L.A.1    Crnic, L.S.2
  • 149
    • 0035825304 scopus 로고    scopus 로고
    • Ts65Dn mice, a model for Down syndrome, have deficits in context discrimination learning suggesting impaired hippocampal function
    • Hyde L.A., Frisone D.F., Crnic L.S. Ts65Dn mice, a model for Down syndrome, have deficits in context discrimination learning suggesting impaired hippocampal function. Behav. Brain Res. 2001, 118:53-60.
    • (2001) Behav. Brain Res. , vol.118 , pp. 53-60
    • Hyde, L.A.1    Frisone, D.F.2    Crnic, L.S.3
  • 152
    • 77951096438 scopus 로고    scopus 로고
    • Enlarged brain ventricles and impaired neurogenesis in the Ts1Cje and Ts2Cje mouse models of Down syndrome
    • Ishihara K., Amano K., Takaki E., Shimohata A., Sago H., Epstein C.J., Yamakawa K. Enlarged brain ventricles and impaired neurogenesis in the Ts1Cje and Ts2Cje mouse models of Down syndrome. Cereb. Cortex 2009, 10.1093/cercor/bhp1176.
    • (2009) Cereb. Cortex
    • Ishihara, K.1    Amano, K.2    Takaki, E.3    Shimohata, A.4    Sago, H.5    Epstein, C.J.6    Yamakawa, K.7
  • 154
    • 0032401643 scopus 로고    scopus 로고
    • Biomarkers of oxidative stress are significantly elevated in Down syndrome
    • Jovanovic S.V., Clements D., MacLeod K. Biomarkers of oxidative stress are significantly elevated in Down syndrome. Free Radic. Biol. Med. 1998, 25:1044-1048.
    • (1998) Free Radic. Biol. Med. , vol.25 , pp. 1044-1048
    • Jovanovic, S.V.1    Clements, D.2    MacLeod, K.3
  • 158
    • 0009868621 scopus 로고
    • Down syndrome
    • Plenum Press, A. Peters, E.J. Jones (Eds.)
    • Kemper T.L. Down syndrome. In Cerebral Cortex 1991, 511-526. Plenum Press. A. Peters, E.J. Jones (Eds.).
    • (1991) In Cerebral Cortex , pp. 511-526
    • Kemper, T.L.1
  • 159
    • 0028306111 scopus 로고
    • Magnetic resonance imaging analysis of age-related changes in the brains of individuals with Down's syndrome
    • Kesslak J.P., Nagata S.F., Lott I., Nalciouglu O. Magnetic resonance imaging analysis of age-related changes in the brains of individuals with Down's syndrome. Neurology 1994, 44:1039-1045.
    • (1994) Neurology , vol.44 , pp. 1039-1045
    • Kesslak, J.P.1    Nagata, S.F.2    Lott, I.3    Nalciouglu, O.4
  • 160
    • 0028980163 scopus 로고
    • Early amyloid-fl deposits show different immunoreactivity to the amino- and carboxy-terminal regions of fl-peptide in Alzheimer' s disease and Down's syndrome brain
    • Kida E., Wisniewski K.E., Wisniewski H.M. Early amyloid-fl deposits show different immunoreactivity to the amino- and carboxy-terminal regions of fl-peptide in Alzheimer' s disease and Down's syndrome brain. Neurosci. Lett. 1995, 193:105-108.
    • (1995) Neurosci. Lett. , vol.193 , pp. 105-108
    • Kida, E.1    Wisniewski, K.E.2    Wisniewski, H.M.3
  • 161
    • 57549088119 scopus 로고    scopus 로고
    • Minocycline and neurodegenerative diseases
    • Kim H.S., Suh Y.H. Minocycline and neurodegenerative diseases. Behav. Brain Res. 2009, 196:168-179.
    • (2009) Behav. Brain Res. , vol.196 , pp. 168-179
    • Kim, H.S.1    Suh, Y.H.2
  • 162
    • 0034234963 scopus 로고    scopus 로고
    • A conserved family of calcineurin regulators
    • Kingsbury T.J., Cunningham K.W. A conserved family of calcineurin regulators. Genes Dev. 2000, 14:1595-1604.
    • (2000) Genes Dev. , vol.14 , pp. 1595-1604
    • Kingsbury, T.J.1    Cunningham, K.W.2
  • 165
    • 4644250821 scopus 로고    scopus 로고
    • Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome
    • Kleschevnikov A.M., Belichenko P.V., Villar A.J., Epstein C.J., Malenka R.C., Mobley W.C. Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome. J. Neurosci. 2004, 24:8153-8160.
    • (2004) J. Neurosci. , vol.24 , pp. 8153-8160
    • Kleschevnikov, A.M.1    Belichenko, P.V.2    Villar, A.J.3    Epstein, C.J.4    Malenka, R.C.5    Mobley, W.C.6
  • 168
    • 0036368653 scopus 로고    scopus 로고
    • Relation of medial temporal lobe volumes to age and memory function in nondemented adults with Down's syndrome: implications for the prodromal phase of Alzheimer's disease
    • Krasuski J.S., Alexander G.E., Horwitz B., rapoport S.I., Schapiro M.B. Relation of medial temporal lobe volumes to age and memory function in nondemented adults with Down's syndrome: implications for the prodromal phase of Alzheimer's disease. Am. J. Psychiatry 2002, 159:74-81.
    • (2002) Am. J. Psychiatry , vol.159 , pp. 74-81
    • Krasuski, J.S.1    Alexander, G.E.2    Horwitz, B.3    rapoport, S.I.4    Schapiro, M.B.5
  • 169
    • 53049084940 scopus 로고    scopus 로고
    • Selective attention deficits associated with mild cognitive impairment and early stage Alzheimer's disease in adults with Down syndrome
    • Krinsky-McHale S.J., Devenny D.A., Kittler P., Silverman W. Selective attention deficits associated with mild cognitive impairment and early stage Alzheimer's disease in adults with Down syndrome. Am. J. Ment. Retard. 2008, 113:369-386.
    • (2008) Am. J. Ment. Retard. , vol.113 , pp. 369-386
    • Krinsky-McHale, S.J.1    Devenny, D.A.2    Kittler, P.3    Silverman, W.4
  • 170
    • 0036201972 scopus 로고    scopus 로고
    • Changes in explicit memory associated with early dementia in adults with Down's syndrome
    • Krinsky-McHale S.J., Devenny D.A., Silverman W.P. Changes in explicit memory associated with early dementia in adults with Down's syndrome. J. Intellect. Disabil. Res. 2002, 46:198-208.
    • (2002) J. Intellect. Disabil. Res. , vol.46 , pp. 198-208
    • Krinsky-McHale, S.J.1    Devenny, D.A.2    Silverman, W.P.3
  • 171
    • 0036236357 scopus 로고    scopus 로고
    • Calcineurin acts via the C-terminus of NR2A to modulate desensitization of NMDA receptors
    • Krupp J.J., Vissel B., Thomas C.G., Heinemann S.F., Westbrook G.L. Calcineurin acts via the C-terminus of NR2A to modulate desensitization of NMDA receptors. Neuropharmacology 2002, 42:593-602.
    • (2002) Neuropharmacology , vol.42 , pp. 593-602
    • Krupp, J.J.1    Vissel, B.2    Thomas, C.G.3    Heinemann, S.F.4    Westbrook, G.L.5
  • 172
    • 4444336568 scopus 로고    scopus 로고
    • Deficits of neuronal density in CA1 and synaptic density in the dentate gyrus, CA3 and CA1, in a mouse model of Down syndrome
    • Kurt A.M., Kafa I.M., Dierssen M., Davies C.D. Deficits of neuronal density in CA1 and synaptic density in the dentate gyrus, CA3 and CA1, in a mouse model of Down syndrome. Brain Res. 2004, 1022:101-109.
    • (2004) Brain Res. , vol.1022 , pp. 101-109
    • Kurt, A.M.1    Kafa, I.M.2    Dierssen, M.3    Davies, C.D.4
  • 173
    • 0033970177 scopus 로고    scopus 로고
    • Synaptic deficit in the temporal cortex of partial trisomy 16 (Ts65Dn) mice
    • Kurt M.A., Davies D.C., Kidd M., Dierssen M., Florez J. Synaptic deficit in the temporal cortex of partial trisomy 16 (Ts65Dn) mice. Brain Res. 2000, 858:191-197.
    • (2000) Brain Res. , vol.858 , pp. 191-197
    • Kurt, M.A.1    Davies, D.C.2    Kidd, M.3    Dierssen, M.4    Florez, J.5
  • 176
    • 19644388489 scopus 로고    scopus 로고
    • Verbal and visuospatial working memory deficits in children with Down syndrome
    • Lanfranchi S., Cornoldi C., Vianello R. Verbal and visuospatial working memory deficits in children with Down syndrome. Am. J. Mental Reterd. 2004, 109:456-466.
    • (2004) Am. J. Mental Reterd. , vol.109 , pp. 456-466
    • Lanfranchi, S.1    Cornoldi, C.2    Vianello, R.3
  • 178
    • 0042093737 scopus 로고    scopus 로고
    • Working memory in children and adolescents with Down syndrome: evidence from a colour memory experiment
    • Laws G. Working memory in children and adolescents with Down syndrome: evidence from a colour memory experiment. J. Child Psychol. Psychiatry 2002, 43:353-364.
    • (2002) J. Child Psychol. Psychiatry , vol.43 , pp. 353-364
    • Laws, G.1
  • 179
    • 0026941497 scopus 로고
    • The disordered neuronal cytoskeleton in Alzheimer's disease
    • Lee V.M., Trojanowski J.Q. The disordered neuronal cytoskeleton in Alzheimer's disease. Curr. Opin. Neurobiol. 1992, 2:653-656.
    • (1992) Curr. Opin. Neurobiol. , vol.2 , pp. 653-656
    • Lee, V.M.1    Trojanowski, J.Q.2
  • 181
    • 0030007964 scopus 로고    scopus 로고
    • Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation
    • Lemere C.A., Blusztajn J.K., Yamaguchi H., Wisniewski T., Saido T.C., Selkoe D.J. Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation. Neurobiol. Dis. 1996, 3:16-32.
    • (1996) Neurobiol. Dis. , vol.3 , pp. 16-32
    • Lemere, C.A.1    Blusztajn, J.K.2    Yamaguchi, H.3    Wisniewski, T.4    Saido, T.C.5    Selkoe, D.J.6
  • 182
    • 17544399111 scopus 로고    scopus 로고
    • Early amyloid deposition in the medial temporal lobe of young Down syndrome patients: a regional quantitative analysis
    • Leverenz J.B., Raskind M.A. Early amyloid deposition in the medial temporal lobe of young Down syndrome patients: a regional quantitative analysis. Exp. Neurol. 1998, 150:296-304.
    • (1998) Exp. Neurol. , vol.150 , pp. 296-304
    • Leverenz, J.B.1    Raskind, M.A.2
  • 184
    • 67249087641 scopus 로고    scopus 로고
    • Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake
    • Li S., Hong S., Shepardson N.E., Walsh D.M., Shankar G.M., Selkoe D. Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake. Neuron 2009, 62:788-801.
    • (2009) Neuron , vol.62 , pp. 788-801
    • Li, S.1    Hong, S.2    Shepardson, N.E.3    Walsh, D.M.4    Shankar, G.M.5    Selkoe, D.6
  • 185
    • 34447331007 scopus 로고    scopus 로고
    • Duplication of the entire 22.9 Mb human chromosome 21 syntenic region on mouse chromosome 16 causes cardiovascular and gastrointestinal abnormalities
    • Li Z., Yu T., Morishima M., Pao A., LaDuca J., Conroy J., Nowak N., Matsui S.I., Shiraishi I., Yu E.Y. Duplication of the entire 22.9 Mb human chromosome 21 syntenic region on mouse chromosome 16 causes cardiovascular and gastrointestinal abnormalities. Hum. Mol. Genet. 2007, 16:1359-1366.
    • (2007) Hum. Mol. Genet. , vol.16 , pp. 1359-1366
    • Li, Z.1    Yu, T.2    Morishima, M.3    Pao, A.4    LaDuca, J.5    Conroy, J.6    Nowak, N.7    Matsui, S.I.8    Shiraishi, I.9    Yu, E.Y.10
  • 186
    • 0028236667 scopus 로고
    • Regulation of NMDA channel function by endogenous Ca(2+)-dependent phosphatase
    • Lieberman D.N., Mody I. Regulation of NMDA channel function by endogenous Ca(2+)-dependent phosphatase. Nature 1994, 369:235-239.
    • (1994) Nature , vol.369 , pp. 235-239
    • Lieberman, D.N.1    Mody, I.2
  • 189
    • 33947305482 scopus 로고    scopus 로고
    • Characterization of Abeta11-40/42 peptide deposition in Alzheimer's disease and young Down's syndrome brains: implication of N-terminally truncated Abeta species in the pathogenesis of Alzheimer's disease
    • Liu K., Solano I., Mann D., Lemere C., Mercken M., Trojanowski J.Q., Lee V.M. Characterization of Abeta11-40/42 peptide deposition in Alzheimer's disease and young Down's syndrome brains: implication of N-terminally truncated Abeta species in the pathogenesis of Alzheimer's disease. Acta Neuropathol. 2006, 112.
    • (2006) Acta Neuropathol. , vol.112
    • Liu, K.1    Solano, I.2    Mann, D.3    Lemere, C.4    Mercken, M.5    Trojanowski, J.Q.6    Lee, V.M.7
  • 192
    • 33746585652 scopus 로고    scopus 로고
    • Hippocampal hypocellularity in the Ts65Dn mouse originates early in development
    • Lorenzi H.A., Reeves R.H. Hippocampal hypocellularity in the Ts65Dn mouse originates early in development. Brain Res. 2006, 1104:153-159.
    • (2006) Brain Res. , vol.1104 , pp. 153-159
    • Lorenzi, H.A.1    Reeves, R.H.2
  • 193
    • 0034854122 scopus 로고    scopus 로고
    • Down syndrome and Alzheimer's disease: a link between development and aging
    • Lott I.T., Head E. Down syndrome and Alzheimer's disease: a link between development and aging. Ment. Retard. Dev. Disabil. Res. Rev. 2001, 7:172-178.
    • (2001) Ment. Retard. Dev. Disabil. Res. Rev. , vol.7 , pp. 172-178
    • Lott, I.T.1    Head, E.2
  • 194
    • 11444269588 scopus 로고    scopus 로고
    • Alzheimer disease and Down syndrome: factors in pathogenesis
    • Lott I.T., Head E. Alzheimer disease and Down syndrome: factors in pathogenesis. Neurobiol. Aging 2005, 26:383-389.
    • (2005) Neurobiol. Aging , vol.26 , pp. 383-389
    • Lott, I.T.1    Head, E.2
  • 195
    • 0036311075 scopus 로고    scopus 로고
    • Down syndrome and Alzheimer disease: response to donepezil
    • Lott I.T., Osann K., Doran E., Nelson L. Down syndrome and Alzheimer disease: response to donepezil. Arch. Neurol. 2002, 59:1133-1136.
    • (2002) Arch. Neurol. , vol.59 , pp. 1133-1136
    • Lott, I.T.1    Osann, K.2    Doran, E.3    Nelson, L.4
  • 196
    • 0035237418 scopus 로고    scopus 로고
    • Down syndrome patients start early prenatal life with normal cholinergic, monoaminergic and serotoninergic innervation
    • Lubec B., Yoo B.C., Dierssen M., Balic N., Lubec G. Down syndrome patients start early prenatal life with normal cholinergic, monoaminergic and serotoninergic innervation. J. Neural. Transm. Suppl. 2001, 61:303-310.
    • (2001) J. Neural. Transm. Suppl. , vol.61 , pp. 303-310
    • Lubec, B.1    Yoo, B.C.2    Dierssen, M.3    Balic, N.4    Lubec, G.5
  • 197
    • 44549086153 scopus 로고    scopus 로고
    • Infusion of FK506, a specific inhibitor of calcineurin, induces potent tau hyperphosphorylation in mouse brain
    • Luo J., Ma J., Yu D.Y., Bu F., Zhang W., Tu L.H., Wei Q. Infusion of FK506, a specific inhibitor of calcineurin, induces potent tau hyperphosphorylation in mouse brain. Brain Res. Bull. 2008, 76:464-468.
    • (2008) Brain Res. Bull. , vol.76 , pp. 464-468
    • Luo, J.1    Ma, J.2    Yu, D.Y.3    Bu, F.4    Zhang, W.5    Tu, L.H.6    Wei, Q.7
  • 198
    • 0024503377 scopus 로고
    • The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome
    • Mann D.M., Esiri M.M. The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome. J. Neurol. Sci. 1989, 89:169-179.
    • (1989) J. Neurol. Sci. , vol.89 , pp. 169-179
    • Mann, D.M.1    Esiri, M.M.2
  • 199
    • 0021814284 scopus 로고
    • Pathological evidence for neurotransmitter deficits in Down's syndrome of middle age
    • Mann D.M., Yates P.O., Marcyniuk B., Ravindra C.R. Pathological evidence for neurotransmitter deficits in Down's syndrome of middle age. J. Ment. Defic. Res. 1985, 29:125-135.
    • (1985) J. Ment. Defic. Res. , vol.29 , pp. 125-135
    • Mann, D.M.1    Yates, P.O.2    Marcyniuk, B.3    Ravindra, C.R.4
  • 200
    • 0017234871 scopus 로고
    • Pyramidal cell abnormalities in the motor cortex of a child with Down's syndrome: a Golgi study
    • Marin-Padilla M. Pyramidal cell abnormalities in the motor cortex of a child with Down's syndrome: a Golgi study. J. Comp. Neurol. 1976, 16:63-81.
    • (1976) J. Comp. Neurol. , vol.16 , pp. 63-81
    • Marin-Padilla, M.1
  • 201
    • 0037151272 scopus 로고    scopus 로고
    • Differential effects of environmental enrichment on behavior and learning of male and female Ts65Dn mice, a model for Down syndrome
    • Martinez-Cue C., Baamonde C., Lumbreras M., Paz J., Davisson M.T., Schmidt C., Dierssen M., Florez J. Differential effects of environmental enrichment on behavior and learning of male and female Ts65Dn mice, a model for Down syndrome. Behav. Brain Res. 2002, 134:185-200.
    • (2002) Behav. Brain Res. , vol.134 , pp. 185-200
    • Martinez-Cue, C.1    Baamonde, C.2    Lumbreras, M.3    Paz, J.4    Davisson, M.T.5    Schmidt, C.6    Dierssen, M.7    Florez, J.8
  • 202
    • 23744473479 scopus 로고    scopus 로고
    • Behavioral, cognitive and biochemical responses to different environmental conditions in male Ts65Dn mice, a model of Down syndrome
    • Martinez-Cue C., Rueda N., Garcia E., Davisson M.T., Schmidt C., Florez J. Behavioral, cognitive and biochemical responses to different environmental conditions in male Ts65Dn mice, a model of Down syndrome. Behav. Brain Res. 2005, 163:174-185.
    • (2005) Behav. Brain Res. , vol.163 , pp. 174-185
    • Martinez-Cue, C.1    Rueda, N.2    Garcia, E.3    Davisson, M.T.4    Schmidt, C.5    Florez, J.6
  • 203
    • 0015314813 scopus 로고
    • Mongolism and sex: a common problem of cell proliferation?
    • Mittwoch U. Mongolism and sex: a common problem of cell proliferation?. J. Med. Genet. 1971, 9:92-95.
    • (1971) J. Med. Genet. , vol.9 , pp. 92-95
    • Mittwoch, U.1
  • 204
    • 0019974174 scopus 로고
    • Trisomy 16 in the mouse fetus associated with generalized edema and cardiovascular and urinary tract anomalies
    • Miyabara S., Gropp A., Winking H. Trisomy 16 in the mouse fetus associated with generalized edema and cardiovascular and urinary tract anomalies. Teratology 1982, 25:369-380.
    • (1982) Teratology , vol.25 , pp. 369-380
    • Miyabara, S.1    Gropp, A.2    Winking, H.3
  • 206
    • 36549075184 scopus 로고    scopus 로고
    • A yeast model of Down syndrome
    • Moldrich R.X. A yeast model of Down syndrome. Int. J. Dev. Neurosci. 2007, 25:539-543.
    • (2007) Int. J. Dev. Neurosci. , vol.25 , pp. 539-543
    • Moldrich, R.X.1
  • 208
    • 34548431071 scopus 로고    scopus 로고
    • The power of comparative and developmental studies for mouse models of Down syndrome
    • Moore C.S., Roper R.J. The power of comparative and developmental studies for mouse models of Down syndrome. Mamm. Genome 2007, 18:431-443.
    • (2007) Mamm. Genome , vol.18 , pp. 431-443
    • Moore, C.S.1    Roper, R.J.2
  • 211
    • 47549096987 scopus 로고    scopus 로고
    • Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome
    • Morice E., Andreae L.C., Cooke S.F., Vanes L., Fisher E.M., Tybulewicz V.L., Bliss T.V. Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome. Learn. Mem. 2008, 15:492-500.
    • (2008) Learn. Mem. , vol.15 , pp. 492-500
    • Morice, E.1    Andreae, L.C.2    Cooke, S.F.3    Vanes, L.4    Fisher, E.M.5    Tybulewicz, V.L.6    Bliss, T.V.7
  • 212
    • 3142691054 scopus 로고    scopus 로고
    • Phenotypic expression of the targeted null-mutation in the dopamine transporter gene varies as a function of the genetic background
    • Morice E., Denis C., Giros B., Nosten-Bertrand M. Phenotypic expression of the targeted null-mutation in the dopamine transporter gene varies as a function of the genetic background. Eur. J. Neurosci. 2004, 20:120-126.
    • (2004) Eur. J. Neurosci. , vol.20 , pp. 120-126
    • Morice, E.1    Denis, C.2    Giros, B.3    Nosten-Bertrand, M.4
  • 213
    • 0024602541 scopus 로고
    • Age-related changes in the density and morphology of plaques and neurofibrillary tangles in Down syndrome brain
    • Motte J., Williams R.S. Age-related changes in the density and morphology of plaques and neurofibrillary tangles in Down syndrome brain. Acta Neuropathol. 1989, 77:535-546.
    • (1989) Acta Neuropathol. , vol.77 , pp. 535-546
    • Motte, J.1    Williams, R.S.2
  • 214
    • 0027324260 scopus 로고
    • Galaninergic innervation of the cholinergic vertical limb of the diagonal band (Ch2) and bed nucleus of the stria terminalis in aging. Alzheimer's disease and Down's syndrome
    • Mufson E.J., Cochran E., Benzing W., Kordower J.H. Galaninergic innervation of the cholinergic vertical limb of the diagonal band (Ch2) and bed nucleus of the stria terminalis in aging. Alzheimer's disease and Down's syndrome. Dementia 1993, 4:237-250.
    • (1993) Dementia , vol.4 , pp. 237-250
    • Mufson, E.J.1    Cochran, E.2    Benzing, W.3    Kordower, J.H.4
  • 215
    • 0000631837 scopus 로고    scopus 로고
    • Down syndrome in cognitive neuroscience perspective
    • MIT Press, Cambridge, MA, H. Tager-Flusberg (Ed.)
    • Nadel L. Down syndrome in cognitive neuroscience perspective. Neurodevelopmental Disorders 1999, 197-222. MIT Press, Cambridge, MA. H. Tager-Flusberg (Ed.).
    • (1999) Neurodevelopmental Disorders , pp. 197-222
    • Nadel, L.1
  • 216
    • 0042025827 scopus 로고    scopus 로고
    • Down's syndrome: a genetic disorder in biobehavioral perspective
    • Nadel L. Down's syndrome: a genetic disorder in biobehavioral perspective. Genes Brain Behav. 2003, 2:156-166.
    • (2003) Genes Brain Behav. , vol.2 , pp. 156-166
    • Nadel, L.1
  • 218
    • 65149090058 scopus 로고    scopus 로고
    • Spine microdomains for postsynaptic signaling and plasticity
    • Newpher T.M., Ehlers M.D. Spine microdomains for postsynaptic signaling and plasticity. Trends Cell Biol. 2009, 19:218-227.
    • (2009) Trends Cell Biol. , vol.19 , pp. 218-227
    • Newpher, T.M.1    Ehlers, M.D.2
  • 220
    • 64649084926 scopus 로고    scopus 로고
    • Diagnosing Alzheimer's dementia in Down syndrome: problems and possible solutions
    • Nieuwenhuis-Mark R.E. Diagnosing Alzheimer's dementia in Down syndrome: problems and possible solutions. Res. Dev. Disabil. 2009, 30:827-838.
    • (2009) Res. Dev. Disabil. , vol.30 , pp. 827-838
    • Nieuwenhuis-Mark, R.E.1
  • 221
    • 28844467724 scopus 로고    scopus 로고
    • Human chromosome 21/Down syndrome gene function and pathway database
    • Nikolaienko A., Nguyen C., Crine L.S., Cios K.J., Gardiner K. Human chromosome 21/Down syndrome gene function and pathway database. Gene 2005, 364:90-98.
    • (2005) Gene , vol.364 , pp. 90-98
    • Nikolaienko, A.1    Nguyen, C.2    Crine, L.S.3    Cios, K.J.4    Gardiner, K.5
  • 223
    • 0023719140 scopus 로고
    • Babbling in prelinguistic retarded children
    • Oller K., Siebert J.M. Babbling in prelinguistic retarded children. Am. J. Ment. Retard. 1988, 92:369-375.
    • (1988) Am. J. Ment. Retard. , vol.92 , pp. 369-375
    • Oller, K.1    Siebert, J.M.2
  • 224
    • 7444231620 scopus 로고    scopus 로고
    • A chromosome 21 critical region does not cause specific Down syndrome phenotypes
    • Olson L.E., Richtsmeier J.T., Leszl J., Reeves R.H. A chromosome 21 critical region does not cause specific Down syndrome phenotypes. Science 2004, 306:687-690.
    • (2004) Science , vol.306 , pp. 687-690
    • Olson, L.E.1    Richtsmeier, J.T.2    Leszl, J.3    Reeves, R.H.4
  • 225
    • 3042612213 scopus 로고    scopus 로고
    • Down syndrome mouse models Ts65Dn, Ts1Cje, and Ms1Cje/Ts65Dn exhibit variable severity of cerebellar phenotypes
    • Olson L.E., Roper R.J., Baxter L.L., Carlson E.J., Epstein C.J., Reeves R.H. Down syndrome mouse models Ts65Dn, Ts1Cje, and Ms1Cje/Ts65Dn exhibit variable severity of cerebellar phenotypes. Dev. Dyn. 2004, 230:581-589.
    • (2004) Dev. Dyn. , vol.230 , pp. 581-589
    • Olson, L.E.1    Roper, R.J.2    Baxter, L.L.3    Carlson, E.J.4    Epstein, C.J.5    Reeves, R.H.6
  • 228
    • 0038687498 scopus 로고    scopus 로고
    • The neuropsychology of Down syndrome: evidence for hippocampal dysfunction
    • Pennington B.F., Moon J., Edgin J., Stedron J., Nadel L. The neuropsychology of Down syndrome: evidence for hippocampal dysfunction. Child Dev. 2003, 74:75-93.
    • (2003) Child Dev. , vol.74 , pp. 75-93
    • Pennington, B.F.1    Moon, J.2    Edgin, J.3    Stedron, J.4    Nadel, L.5
  • 230
    • 0030902887 scopus 로고    scopus 로고
    • Reduced inferior olivary neuron number in Early Down syndrome
    • Pine S.S., Landing B.H., Shankle W.R. Reduced inferior olivary neuron number in Early Down syndrome. Pediatr. Pathol. Lab. Med. 1997, 17:537-545.
    • (1997) Pediatr. Pathol. Lab. Med. , vol.17 , pp. 537-545
    • Pine, S.S.1    Landing, B.H.2    Shankle, W.R.3
  • 231
    • 0035836647 scopus 로고    scopus 로고
    • Amygdala and hippocampal volumes in children with Down syndrome: a high resolution MRI study
    • Pinter J.D., Brown W.E., Schmitt J.E., Capone G.T., Reiss A.L. Amygdala and hippocampal volumes in children with Down syndrome: a high resolution MRI study. Neurology 2001, 10:972-974.
    • (2001) Neurology , vol.10 , pp. 972-974
    • Pinter, J.D.1    Brown, W.E.2    Schmitt, J.E.3    Capone, G.T.4    Reiss, A.L.5
  • 233
    • 0036119913 scopus 로고    scopus 로고
    • A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Down syndrome and Alzheimer's disease-pilot study
    • Group., D. s. A. S.
    • Prasher V.P., Huxley A., Haque M.S. A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Down syndrome and Alzheimer's disease-pilot study. Int. J. Geriatr. Psychiatry 2002, 17:270-278. Group., D. s. A. S.
    • (2002) Int. J. Geriatr. Psychiatry , vol.17 , pp. 270-278
    • Prasher, V.P.1    Huxley, A.2    Haque, M.S.3
  • 234
    • 0032585844 scopus 로고    scopus 로고
    • The " gene dosage effect" hypothesis versus the " amplified developmental instability" hypothesis in Down syndrome
    • Pritchard M.A., Kola I. The " gene dosage effect" hypothesis versus the " amplified developmental instability" hypothesis in Down syndrome. J. Neural. Transm. Suppl. 1999, 57:293-303.
    • (1999) J. Neural. Transm. Suppl. , vol.57 , pp. 293-303
    • Pritchard, M.A.1    Kola, I.2
  • 235
    • 16244410472 scopus 로고    scopus 로고
    • Impaired verbal short-term memory in Down syndrome reflects a capacity limitation rather than atypically rapid forgetting
    • Purser H.R., Jarrold C. Impaired verbal short-term memory in Down syndrome reflects a capacity limitation rather than atypically rapid forgetting. J. Exp. Child Psychol. 2005, 91:1-23.
    • (2005) J. Exp. Child Psychol. , vol.91 , pp. 1-23
    • Purser, H.R.1    Jarrold, C.2
  • 236
    • 35548991458 scopus 로고    scopus 로고
    • Mental retardation in Down syndrome: From gene dosage imbalance to molecular and cellular mechanisms
    • Rachidi M., Lopes C. Mental retardation in Down syndrome: From gene dosage imbalance to molecular and cellular mechanisms. Neurosci. Res. 2007, 59:349-369.
    • (2007) Neurosci. Res. , vol.59 , pp. 349-369
    • Rachidi, M.1    Lopes, C.2
  • 238
    • 84974325808 scopus 로고
    • Memory and representation in young children with Down syndrome. Exploring deferred imitation and object permanence
    • Rast M., Meltzoff A.N. Memory and representation in young children with Down syndrome. Exploring deferred imitation and object permanence. Dev. Psychopathol. 1995, 7:393-407.
    • (1995) Dev. Psychopathol. , vol.7 , pp. 393-407
    • Rast, M.1    Meltzoff, A.N.2
  • 240
    • 33745107478 scopus 로고    scopus 로고
    • Down syndrome mouse models are looking up
    • Reeves R.H. Down syndrome mouse models are looking up. Trends Mol. Med. 2006, 12:237-240.
    • (2006) Trends Mol. Med. , vol.12 , pp. 237-240
    • Reeves, R.H.1
  • 243
    • 0030942897 scopus 로고    scopus 로고
    • Excitatory amino acids and monoamines in parahippocampal gyrus and frontal cortical pole of adults with Down syndrome
    • Risser D., Lubec G., Cairns N., Herrera-Marschitz M. Excitatory amino acids and monoamines in parahippocampal gyrus and frontal cortical pole of adults with Down syndrome. Life Sci. 1997, 60:1231-1237.
    • (1997) Life Sci. , vol.60 , pp. 1231-1237
    • Risser, D.1    Lubec, G.2    Cairns, N.3    Herrera-Marschitz, M.4
  • 244
    • 0037433652 scopus 로고    scopus 로고
    • Down's syndrome
    • Roizen N.J., Patterson D. Down's syndrome. Lancet 2003, 361:1281-1289.
    • (2003) Lancet , vol.361 , pp. 1281-1289
    • Roizen, N.J.1    Patterson, D.2
  • 245
    • 0008496322 scopus 로고
    • Exceptional cases of language development in mental retardation: The relative autonomy of language as a cognitive system
    • Erlbaum, Hillsdale, NJ, H. Tager-Flusberg (Ed.)
    • Rondal J.A. Exceptional cases of language development in mental retardation: The relative autonomy of language as a cognitive system. Constraints of Language Acquisition 1993, 155-174. Erlbaum, Hillsdale, NJ. H. Tager-Flusberg (Ed.).
    • (1993) Constraints of Language Acquisition , pp. 155-174
    • Rondal, J.A.1
  • 247
    • 33645789057 scopus 로고    scopus 로고
    • Understanding the basis for Down syndrome phenotypes
    • Roper R.J., Reeves R.H. Understanding the basis for Down syndrome phenotypes. PLoS Genet. 2006, 2:231-236.
    • (2006) PLoS Genet. , vol.2 , pp. 231-236
    • Roper, R.J.1    Reeves, R.H.2
  • 248
    • 59849119800 scopus 로고    scopus 로고
    • A neural crest deficit in Down syndrome mice is associated with deficient mitotic response to Sonic hedgehog
    • Roper R.J., VanHorn J.F., Cain C.C., Reeves R.H. A neural crest deficit in Down syndrome mice is associated with deficient mitotic response to Sonic hedgehog. Mech. Dev. 2008, 126:212-219.
    • (2008) Mech. Dev. , vol.126 , pp. 212-219
    • Roper, R.J.1    VanHorn, J.F.2    Cain, C.C.3    Reeves, R.H.4
  • 249
    • 0018852777 scopus 로고
    • Relationship between plaques, tangles, and dementia in Down syndrome
    • Ropper A.H., Williams R.S. Relationship between plaques, tangles, and dementia in Down syndrome. Neurology 1980, 30:639-644.
    • (1980) Neurology , vol.30 , pp. 639-644
    • Ropper, A.H.1    Williams, R.S.2
  • 251
    • 33644617316 scopus 로고    scopus 로고
    • Cognitive executive function in Down's syndrome
    • Rowe J., Lavender A., Turk V. Cognitive executive function in Down's syndrome. Br. J. Clin. Psychol. 2006, 45:5-17.
    • (2006) Br. J. Clin. Psychol. , vol.45 , pp. 5-17
    • Rowe, J.1    Lavender, A.2    Turk, V.3
  • 252
    • 39149111255 scopus 로고    scopus 로고
    • Chronic pentylenetetrazole but not donepezil treatment rescues spatial cognition in Ts65Dn mice, a model for Down syndrome
    • Rueda N., Florez J., Marti{dotless}nez-Cue C. Chronic pentylenetetrazole but not donepezil treatment rescues spatial cognition in Ts65Dn mice, a model for Down syndrome. Neurosci. Lett. 2008, 433:22-27.
    • (2008) Neurosci. Lett. , vol.433 , pp. 22-27
    • Rueda, N.1    Florez, J.2    Martinez-Cue, C.3
  • 253
    • 39149135216 scopus 로고    scopus 로고
    • Effects of chronic administration of SGS-111 during adulthood and during the pre- and post-natal periods on the cognitive deficits of Ts65Dn mice, a model of Down syndrome
    • Rueda N., Florez J., Marti{dotless}nez-Cue C. Effects of chronic administration of SGS-111 during adulthood and during the pre- and post-natal periods on the cognitive deficits of Ts65Dn mice, a model of Down syndrome. Behav. Brain Res. 2008, 188:355-367.
    • (2008) Behav. Brain Res. , vol.188 , pp. 355-367
    • Rueda, N.1    Florez, J.2    Martinez-Cue, C.3
  • 254
    • 18044369095 scopus 로고    scopus 로고
    • Cell proliferation is reduced in the dentate gyrus of aged but not young Ts65Dn mice, a model of Down syndrome
    • Rueda N., Mostany R., Pazos A., Florez J., Martinez-Cue C. Cell proliferation is reduced in the dentate gyrus of aged but not young Ts65Dn mice, a model of Down syndrome. Neurosci. Lett. 2005, 380:197-201.
    • (2005) Neurosci. Lett. , vol.380 , pp. 197-201
    • Rueda, N.1    Mostany, R.2    Pazos, A.3    Florez, J.4    Martinez-Cue, C.5
  • 255
    • 0024342769 scopus 로고
    • Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease
    • Rumble B., Retallack R., Hillbach C. Amyloid A4 protein and its precursor in Down's syndrome and Alzheimer's disease. N. Engl. J. Med. 1989, 320:1446-1454.
    • (1989) N. Engl. J. Med. , vol.320 , pp. 1446-1454
    • Rumble, B.1    Retallack, R.2    Hillbach, C.3
  • 256
    • 4544339881 scopus 로고    scopus 로고
    • Inhibitory interactions of calcineurin (phosphatase 2B) and calmodulin on rat hippocampal NMDA receptors
    • Rycroft B.K., Gibb A.J. Inhibitory interactions of calcineurin (phosphatase 2B) and calmodulin on rat hippocampal NMDA receptors. Neuropharmacology 2004, 47:505-514.
    • (2004) Neuropharmacology , vol.47 , pp. 505-514
    • Rycroft, B.K.1    Gibb, A.J.2
  • 259
    • 0033756144 scopus 로고    scopus 로고
    • Genetic dissection of region associated with behavioral abnormalities in mouse models for Down syndrome
    • Sago H., Carlson E.J., Smith D.J., Rubin E.M., Crnic L.S., Huang T.T., Epstein C.J. Genetic dissection of region associated with behavioral abnormalities in mouse models for Down syndrome. Pediatr. Res. 2000, 48:606-613.
    • (2000) Pediatr. Res. , vol.48 , pp. 606-613
    • Sago, H.1    Carlson, E.J.2    Smith, D.J.3    Rubin, E.M.4    Crnic, L.S.5    Huang, T.T.6    Epstein, C.J.7
  • 261
    • 0037303935 scopus 로고    scopus 로고
    • Traffic at the intersection of neurotrophic factor signaling and neurodegeneration
    • Salehi A., Delcroix J.D., Mobley W.C. Traffic at the intersection of neurotrophic factor signaling and neurodegeneration. Trends Neurosci. 2003, 26:73-80.
    • (2003) Trends Neurosci. , vol.26 , pp. 73-80
    • Salehi, A.1    Delcroix, J.D.2    Mobley, W.C.3
  • 264
    • 0026621718 scopus 로고
    • Nature of mental retardation and dementia in Down syndrome: study with PET, CT, and neuropsychology
    • Schapiro B.L., Haxby J.V., Grady C.L. Nature of mental retardation and dementia in Down syndrome: study with PET, CT, and neuropsychology. Neurobiol. Aging 1992, 13:723-734.
    • (1992) Neurobiol. Aging , vol.13 , pp. 723-734
    • Schapiro, B.L.1    Haxby, J.V.2    Grady, C.L.3
  • 265
    • 0025071591 scopus 로고
    • Brain growth in Down syndrome subjects 15 to 22 weeks of gestational age and birth to 60 months
    • Schmidt-Sidor B., Wisniewski K.E., Shepard T.H., Sersen E.A. Brain growth in Down syndrome subjects 15 to 22 weeks of gestational age and birth to 60 months. Clin. Neuropathol. 1990, 9:181-190.
    • (1990) Clin. Neuropathol. , vol.9 , pp. 181-190
    • Schmidt-Sidor, B.1    Wisniewski, K.E.2    Shepard, T.H.3    Sersen, E.A.4
  • 266
    • 0031043034 scopus 로고    scopus 로고
    • Similar deficits of central histaminergic system in patients with Down syndrome and Alzheimer disease
    • Schneider C., Risser D., Kirkner L., Kitzmüller E., Cairns N., Prast H., et al. Similar deficits of central histaminergic system in patients with Down syndrome and Alzheimer disease. Neurosci. Lett. 1997, 222:183-186.
    • (1997) Neurosci. Lett. , vol.222 , pp. 183-186
    • Schneider, C.1    Risser, D.2    Kirkner, L.3    Kitzmüller, E.4    Cairns, N.5    Prast, H.6
  • 267
    • 0033952295 scopus 로고    scopus 로고
    • Diminished glutathione levels cause spontaneous and mitochondria-mediated cell death in neurons from trisomy 16 mice: a model of Down's syndrome
    • Schuchmann S., Heinemann U. Diminished glutathione levels cause spontaneous and mitochondria-mediated cell death in neurons from trisomy 16 mice: a model of Down's syndrome. J. Neurochem. 2000, 74:1205-1214.
    • (2000) J. Neurochem. , vol.74 , pp. 1205-1214
    • Schuchmann, S.1    Heinemann, U.2
  • 268
    • 0033967558 scopus 로고    scopus 로고
    • Increased mitochondrial superoxide generation in neurons from trisomy 16 mice: a model of Down's syndrome
    • Schuchmann S., Heinemann U. Increased mitochondrial superoxide generation in neurons from trisomy 16 mice: a model of Down's syndrome. Free Radic. Biol. Med. 2000, 28:235-250.
    • (2000) Free Radic. Biol. Med. , vol.28 , pp. 235-250
    • Schuchmann, S.1    Heinemann, U.2
  • 269
    • 0026706872 scopus 로고
    • Neurohistological findings in the parietal cortex of children with chromosome aberrations
    • Schulz E., Scholz B. Neurohistological findings in the parietal cortex of children with chromosome aberrations. J. Hirnforsch. 1992, 33:37-62.
    • (1992) J. Hirnforsch. , vol.33 , pp. 37-62
    • Schulz, E.1    Scholz, B.2
  • 270
    • 18244388693 scopus 로고    scopus 로고
    • Abnormal APP, cholinergic and cognitive function in Ts65Dn Down's model mice
    • Seo H., Isacson O. Abnormal APP, cholinergic and cognitive function in Ts65Dn Down's model mice. Exp. Neurol. 2005, 193:469-480.
    • (2005) Exp. Neurol. , vol.193 , pp. 469-480
    • Seo, H.1    Isacson, O.2
  • 273
    • 0020661091 scopus 로고
    • Down syndrome: a sistruption of homeostasis
    • Shapiro B.L. Down syndrome: a sistruption of homeostasis. Am. J. Med. Genet. 1983, 14:241-296.
    • (1983) Am. J. Med. Genet. , vol.14 , pp. 241-296
    • Shapiro, B.L.1
  • 274
    • 0037166050 scopus 로고    scopus 로고
    • Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome
    • Shim S.K., Lubec G. Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome. Neurosci. Lett. 2002, 324:209-212.
    • (2002) Neurosci. Lett. , vol.324 , pp. 209-212
    • Shim, S.K.1    Lubec, G.2
  • 276
    • 0032729863 scopus 로고    scopus 로고
    • Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome
    • Siarey R.J., Carlson E.J., Epstein C.J., Balbo A., Rapoport S.I., Galdzicki Z. Increased synaptic depression in the Ts65Dn mouse, a model for mental retardation in Down syndrome. Neuropharmacology 1999, 38:1917-1920.
    • (1999) Neuropharmacology , vol.38 , pp. 1917-1920
    • Siarey, R.J.1    Carlson, E.J.2    Epstein, C.J.3    Balbo, A.4    Rapoport, S.I.5    Galdzicki, Z.6
  • 277
    • 0031414807 scopus 로고    scopus 로고
    • Altered long-term potentiation in the young and old Ts65Dn mouse, a model for Down syndrome
    • Siarey R.J., Stoll J., Rapoport S.I., Galdzicki Z. Altered long-term potentiation in the young and old Ts65Dn mouse, a model for Down syndrome. Neuropharmacology 1997, 36:1549-1554.
    • (1997) Neuropharmacology , vol.36 , pp. 1549-1554
    • Siarey, R.J.1    Stoll, J.2    Rapoport, S.I.3    Galdzicki, Z.4
  • 278
    • 21344435258 scopus 로고    scopus 로고
    • Abnormal synaptic plasticity in the Ts1Cje segmental trisomy 16 mouse model of Down syndrome
    • Siarey R.J., Villar A.J., Epstein C.J., Galdzicki Z. Abnormal synaptic plasticity in the Ts1Cje segmental trisomy 16 mouse model of Down syndrome. Neuropharmacology 2005, 49:122-128.
    • (2005) Neuropharmacology , vol.49 , pp. 122-128
    • Siarey, R.J.1    Villar, A.J.2    Epstein, C.J.3    Galdzicki, Z.4
  • 280
    • 0033756376 scopus 로고    scopus 로고
    • Overview on the structure, composition, function, development and plasticity of hippocampal dendritic spines
    • Sorra K.E., Harris K.M. Overview on the structure, composition, function, development and plasticity of hippocampal dendritic spines. Hippocampus 2000, 10:501-511.
    • (2000) Hippocampus , vol.10 , pp. 501-511
    • Sorra, K.E.1    Harris, K.M.2
  • 281
    • 4043159976 scopus 로고    scopus 로고
    • Experimental parameters affecting the Morris water maze performance of a mouse model of Down syndrome
    • Stasko M.R., Costa A.C.S. Experimental parameters affecting the Morris water maze performance of a mouse model of Down syndrome. Behav. Brain Res. 2004, 154:1-17.
    • (2004) Behav. Brain Res. , vol.154 , pp. 1-17
    • Stasko, M.R.1    Costa, A.C.S.2
  • 282
    • 0026795236 scopus 로고
    • Vocal development in infants with Down syndrome and infants who are developing normally
    • Steffens M.L., Oller K., Lynch M., Urbano R. Vocal development in infants with Down syndrome and infants who are developing normally. Am. J. Ment. Retard. 1992, 97:235-246.
    • (1992) Am. J. Ment. Retard. , vol.97 , pp. 235-246
    • Steffens, M.L.1    Oller, K.2    Lynch, M.3    Urbano, R.4
  • 283
    • 0018964370 scopus 로고
    • Spine distribution along the apical dendrites of the pyramidal neurons in Down's syndrome
    • Suetsugu M., Mehraein P. Spine distribution along the apical dendrites of the pyramidal neurons in Down's syndrome. Acta Neuropathol. (Berl.) 1980, 50:207-210.
    • (1980) Acta Neuropathol. (Berl.) , vol.50 , pp. 207-210
    • Suetsugu, M.1    Mehraein, P.2
  • 284
    • 0021092302 scopus 로고
    • The hippocampus in Down's syndrome
    • Sylvester P.E. The hippocampus in Down's syndrome. J. Ment. Defic. Res. 1983, 27(Pt 3):227-236.
    • (1983) J. Ment. Defic. Res. , vol.27 , Issue.PART 3 , pp. 227-236
    • Sylvester, P.E.1
  • 285
    • 0005595085 scopus 로고    scopus 로고
    • Language development in atypical children
    • UCL Press, London, M. Barret (Ed.)
    • Tager-Flusberg H. Language development in atypical children. The Development of Language 1999, 311-348. UCL Press, London. M. Barret (Ed.).
    • (1999) The Development of Language , pp. 311-348
    • Tager-Flusberg, H.1
  • 286
    • 0019419703 scopus 로고
    • Abnormal neuronal development in the visual cortex of the human fetus and infant with down's syndrome. A quantitative and qualitative Golgi study
    • Takashima S., Becker L.E., Armstrong D.L., Chan F. Abnormal neuronal development in the visual cortex of the human fetus and infant with down's syndrome. A quantitative and qualitative Golgi study. Brain Res. 1981, 225:1-21.
    • (1981) Brain Res. , vol.225 , pp. 1-21
    • Takashima, S.1    Becker, L.E.2    Armstrong, D.L.3    Chan, F.4
  • 288
    • 0028361046 scopus 로고
    • Dendritic and histochemical development and ageing in patients with Down's syndrome
    • Takashima S., Iida K., Mito T., Arima M. Dendritic and histochemical development and ageing in patients with Down's syndrome. J. Intellect. Disabil. Res. 1994, 38(Pt 3):265-273.
    • (1994) J. Intellect. Disabil. Res. , vol.38 , Issue.PART 3 , pp. 265-273
    • Takashima, S.1    Iida, K.2    Mito, T.3    Arima, M.4
  • 289
    • 1842683970 scopus 로고    scopus 로고
    • Age-related cortical grey matter reductions in non-demented Down's syndrome adults determined by MRI with voxel-based morphometry
    • Teipel S.J., Alexander G.E., Schapiro M.B., Möller H.J., Rapoport S.I., Hampel H. Age-related cortical grey matter reductions in non-demented Down's syndrome adults determined by MRI with voxel-based morphometry. Brain 2004, 127:811-824.
    • (2004) Brain , vol.127 , pp. 811-824
    • Teipel, S.J.1    Alexander, G.E.2    Schapiro, M.B.3    Möller, H.J.4    Rapoport, S.I.5    Hampel, H.6
  • 291
    • 33745028432 scopus 로고    scopus 로고
    • Neuroanatomy of Down syndrome in vivo: a model of preclinical Alzheimer's disease
    • Teipel S.J., Hampel H. Neuroanatomy of Down syndrome in vivo: a model of preclinical Alzheimer's disease. Behav. Genet. 2006, 36:405-415.
    • (2006) Behav. Genet. , vol.36 , pp. 405-415
    • Teipel, S.J.1    Hampel, H.2
  • 295
    • 0036026027 scopus 로고    scopus 로고
    • Complex sentence production by adolescents with Down syndrome
    • Thordadottir E.T., Chapman R.S., Wagner L. Complex sentence production by adolescents with Down syndrome. Appl. Psychol. 2002, 23:163-183.
    • (2002) Appl. Psychol. , vol.23 , pp. 163-183
    • Thordadottir, E.T.1    Chapman, R.S.2    Wagner, L.3
  • 297
    • 33645505550 scopus 로고    scopus 로고
    • Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers
    • Townsend M., Shankar G.M., Mehta T., Walsh D.M., Selkoe D.J. Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers. J. Physiol. 2006, 572:477-492.
    • (2006) J. Physiol. , vol.572 , pp. 477-492
    • Townsend, M.1    Shankar, G.M.2    Mehta, T.3    Walsh, D.M.4    Selkoe, D.J.5
  • 299
    • 0021960718 scopus 로고
    • Alzheimer changes in nondemented patients younger than sixty-five: possible early stages of Alzheimer's disease and senile dementia of Alzheimer type
    • Ulrich J. Alzheimer changes in nondemented patients younger than sixty-five: possible early stages of Alzheimer's disease and senile dementia of Alzheimer type. Ann. Neurol. 1985, 17:273-277.
    • (1985) Ann. Neurol. , vol.17 , pp. 273-277
    • Ulrich, J.1
  • 300
    • 2342614111 scopus 로고    scopus 로고
    • Memory development and intellectual disabilities
    • discussion 63-64
    • Vicari S. Memory development and intellectual disabilities. Acta Paediatr. Suppl. 2004, 93:60-63. discussion 63-64.
    • (2004) Acta Paediatr. Suppl. , vol.93 , pp. 60-63
    • Vicari, S.1
  • 301
    • 0033990963 scopus 로고    scopus 로고
    • Implicit and explicit memory: a functional dissociation in persons with Down syndrome
    • Vicari S., Bellucci S., Carlesimo G.A. Implicit and explicit memory: a functional dissociation in persons with Down syndrome. Neuropsychologia 2000, 38:240-251.
    • (2000) Neuropsychologia , vol.38 , pp. 240-251
    • Vicari, S.1    Bellucci, S.2    Carlesimo, G.A.3
  • 302
    • 18644372777 scopus 로고    scopus 로고
    • Visual and spatial long-term memory: differential pattern of impairments in Williams and Down syndromes
    • Vicari S., Bellucci S., Carlesimo G.A. Visual and spatial long-term memory: differential pattern of impairments in Williams and Down syndromes. Dev. Med. Child Neurol. 2005, 47:305-311.
    • (2005) Dev. Med. Child Neurol. , vol.47 , pp. 305-311
    • Vicari, S.1    Bellucci, S.2    Carlesimo, G.A.3
  • 303
    • 18944397794 scopus 로고    scopus 로고
    • Identification and characterization of a new Down syndrome model, Ts[Rb(12. 1716)]2Cje, resulting from a spontaneous Robertsonian fusion between T(171)65Dn and mouse chromosome 12
    • Villar A.J., Belichenko P.V., Gillespie A.M., Kozy H.M., Mobley W.C., Epstein C.J. Identification and characterization of a new Down syndrome model, Ts[Rb(12. 1716)]2Cje, resulting from a spontaneous Robertsonian fusion between T(171)65Dn and mouse chromosome 12. Mamm. Genome 2005, 16:79-90.
    • (2005) Mamm. Genome , vol.16 , pp. 79-90
    • Villar, A.J.1    Belichenko, P.V.2    Gillespie, A.M.3    Kozy, H.M.4    Mobley, W.C.5    Epstein, C.J.6
  • 304
    • 0031039294 scopus 로고    scopus 로고
    • Prospective study of the prevalence of Alzheimer-type dementia in institutionalized individuals with Down syndrome
    • Visser F.E., Aldenkamp A.P., van Huffelen A.C., Kuilman M., Overweg J., van Wijk J. Prospective study of the prevalence of Alzheimer-type dementia in institutionalized individuals with Down syndrome. Am. J. Ment. Retard. 1997, 101:400-412.
    • (1997) Am. J. Ment. Retard. , vol.101 , pp. 400-412
    • Visser, F.E.1    Aldenkamp, A.P.2    van Huffelen, A.C.3    Kuilman, M.4    Overweg, J.5    van Wijk, J.6
  • 305
    • 35948996980 scopus 로고    scopus 로고
    • Visual-spatial processing in children and adolescents with Down's syndrome: a computerized assessment of memory skills
    • Visu-Petra L., Benga O., Tincas I., Miclea M. Visual-spatial processing in children and adolescents with Down's syndrome: a computerized assessment of memory skills. J. Intellect. Disabil. Res. 2007, 51:942-952.
    • (2007) J. Intellect. Disabil. Res. , vol.51 , pp. 942-952
    • Visu-Petra, L.1    Benga, O.2    Tincas, I.3    Miclea, M.4
  • 306
    • 0036329013 scopus 로고    scopus 로고
    • Perinatal growth of prefrontal layer III pyramids in Down syndrome
    • Vuksic M., Petanjek Z., Rasin M.R., Kostovic I. Perinatal growth of prefrontal layer III pyramids in Down syndrome. Pediatr. Neurol. 2002, 27:36-38.
    • (2002) Pediatr. Neurol. , vol.27 , pp. 36-38
    • Vuksic, M.1    Petanjek, Z.2    Rasin, M.R.3    Kostovic, I.4
  • 307
    • 0034331425 scopus 로고    scopus 로고
    • Conotruncal anomalies in the trisomy 16 mouse: an immunohistochemical analysis with emphasis on the involvement of the neural crest
    • Waller B.R., McQuinn T., Phelps A.L., Markwald R.R., Lo C.W., Thompson R.P., Wessels A. Conotruncal anomalies in the trisomy 16 mouse: an immunohistochemical analysis with emphasis on the involvement of the neural crest. Anat. Rec. 2000, 260:279-293.
    • (2000) Anat. Rec. , vol.260 , pp. 279-293
    • Waller, B.R.1    McQuinn, T.2    Phelps, A.L.3    Markwald, R.R.4    Lo, C.W.5    Thompson, R.P.6    Wessels, A.7
  • 308
    • 0037041426 scopus 로고    scopus 로고
    • Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
    • Walsh D.M., Klyubin I., Fadeeva J.V., Cullen W.K., Anwyl R., Wolfe M.S., Rowan M.J., Selkoe D.J. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 2002, 416:535-539.
    • (2002) Nature , vol.416 , pp. 535-539
    • Walsh, D.M.1    Klyubin, I.2    Fadeeva, J.V.3    Cullen, W.K.4    Anwyl, R.5    Wolfe, M.S.6    Rowan, M.J.7    Selkoe, D.J.8
  • 310
    • 38949158786 scopus 로고    scopus 로고
    • Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells
    • Wang J.W., David D.J., Monckton J.E., Battaglia F., Hen R. Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells. J. Neurosci. 2008, 28:1374-1384.
    • (2008) J. Neurosci. , vol.28 , pp. 1374-1384
    • Wang, J.W.1    David, D.J.2    Monckton, J.E.3    Battaglia, F.4    Hen, R.5
  • 311
    • 0029976912 scopus 로고    scopus 로고
    • Endocardial cushion development and heart loop architecture in the trisomy 16 mouse
    • Webb S., Anderson R.H., Brown N.A. Endocardial cushion development and heart loop architecture in the trisomy 16 mouse. Dev. Dyn. 1996, 206:301-309.
    • (1996) Dev. Dyn. , vol.206 , pp. 301-309
    • Webb, S.1    Anderson, R.H.2    Brown, N.A.3
  • 312
    • 0031006692 scopus 로고    scopus 로고
    • Cardiac morphology at late fetal stages in the mouse with trisomy 16: consequences for different formation of the atrioventricular junction when compared to humans with trisomy 21
    • Webb S., Brown N.A., Anderson R.H. Cardiac morphology at late fetal stages in the mouse with trisomy 16: consequences for different formation of the atrioventricular junction when compared to humans with trisomy 21. Cardiovasc. Res. 1997, 34:515-524.
    • (1997) Cardiovasc. Res. , vol.34 , pp. 515-524
    • Webb, S.1    Brown, N.A.2    Anderson, R.H.3
  • 314
    • 36849085926 scopus 로고    scopus 로고
    • Fetal Down syndrome brains exhibit aberrant levels of neurotransmitters critical for normal brain development
    • Whittle N., Sartori S.B., Dierssen M., Lubec G., Singewald N. Fetal Down syndrome brains exhibit aberrant levels of neurotransmitters critical for normal brain development. Pediatrics 2007, 120:1465-1471.
    • (2007) Pediatrics , vol.120 , pp. 1465-1471
    • Whittle, N.1    Sartori, S.B.2    Dierssen, M.3    Lubec, G.4    Singewald, N.5
  • 315
    • 0019935804 scopus 로고
    • Plaques, tangles and dementia. A quantitative study
    • Wilcock G.K., Esiri M.M. Plaques, tangles and dementia. A quantitative study. J. Neurol. Sci. 1982, 56:343-356.
    • (1982) J. Neurol. Sci. , vol.56 , pp. 343-356
    • Wilcock, G.K.1    Esiri, M.M.2
  • 316
    • 0033956698 scopus 로고    scopus 로고
    • Cerebellar and frontal lobe hypoplasia in fetuses with trisomy 21: usefulness as combined US markers
    • Winter T.C., Ostrovsky A.A., Komarniski C.A., Uhrich S.B. Cerebellar and frontal lobe hypoplasia in fetuses with trisomy 21: usefulness as combined US markers. Radiology 2000, 214:533-538.
    • (2000) Radiology , vol.214 , pp. 533-538
    • Winter, T.C.1    Ostrovsky, A.A.2    Komarniski, C.A.3    Uhrich, S.B.4
  • 318
    • 0025668992 scopus 로고
    • Down syndrome children often have brain with maturation delay, retardation of growth, and cortical dysgenesis
    • Wisniewski K.E. Down syndrome children often have brain with maturation delay, retardation of growth, and cortical dysgenesis. Am. J. Med. Genet. Suppl 1990, 7:274-281.
    • (1990) Am. J. Med. Genet. Suppl , vol.7 , pp. 274-281
    • Wisniewski, K.E.1
  • 319
  • 321
    • 0028674281 scopus 로고
    • Abnormal neurogenesis and synaptogenesis in Down syndrome
    • Wisniewski K.E., Kida E. Abnormal neurogenesis and synaptogenesis in Down syndrome. Dev. Brain. Dysfunct. 1994, 7:289-301.
    • (1994) Dev. Brain. Dysfunct. , vol.7 , pp. 289-301
    • Wisniewski, K.E.1    Kida, E.2
  • 322
    • 0001865721 scopus 로고
    • Neuronal density and synaptogenesis in the postnatal stage of brain maturation in Down syndrome
    • Raven Press, New York, C.J. Epstein (Ed.)
    • Wisniewski K.E., Laure-Kamionowska M., Connell F., Wen G.Y. Neuronal density and synaptogenesis in the postnatal stage of brain maturation in Down syndrome. The Neurobiology of Down Syndrome 1986, 29-44. Raven Press, New York. C.J. Epstein (Ed.).
    • (1986) The Neurobiology of Down Syndrome , pp. 29-44
    • Wisniewski, K.E.1    Laure-Kamionowska, M.2    Connell, F.3    Wen, G.Y.4
  • 323
    • 0021601145 scopus 로고
    • Evidence of arrest of neurogenesis and synaptogensis in brains of patients with Down's syndrome
    • Wisniewski K.E., Laure-Kamionowska M., Wisniewski H.M. Evidence of arrest of neurogenesis and synaptogensis in brains of patients with Down's syndrome. N. Engl. J. Med. 1984, 311:1187-1188.
    • (1984) N. Engl. J. Med. , vol.311 , pp. 1187-1188
    • Wisniewski, K.E.1    Laure-Kamionowska, M.2    Wisniewski, H.M.3
  • 324
    • 0024411610 scopus 로고
    • Postnatal delay of myelin formation in brains from Down syndrome infants and children
    • Wisniewski K.E., Schmidt-Sidor B. Postnatal delay of myelin formation in brains from Down syndrome infants and children. Clin. Neuropathol. 1989, 8:55-62.
    • (1989) Clin. Neuropathol. , vol.8 , pp. 55-62
    • Wisniewski, K.E.1    Schmidt-Sidor, B.2
  • 325
    • 0021956826 scopus 로고
    • Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome
    • Wisniewski K.E., Wisniewski H.M., Wen G.Y. Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome. Ann. Neurol. 1985, 17:278-282.
    • (1985) Ann. Neurol. , vol.17 , pp. 278-282
    • Wisniewski, K.E.1    Wisniewski, H.M.2    Wen, G.Y.3
  • 326
    • 0029416987 scopus 로고
    • Dephosphorylation of fetal-tau and paired helical filaments-tau by protein phosphatases 1 and 2A and calcineurin
    • Yamamoto H., Hasegawa M., Ono T., Xxxx K., Xxxx T., Ihara Y., Miyamoto E. Dephosphorylation of fetal-tau and paired helical filaments-tau by protein phosphatases 1 and 2A and calcineurin. J Biochem (Tokyo) 1995, 118:1224-1231.
    • (1995) J Biochem (Tokyo) , vol.118 , pp. 1224-1231
    • Yamamoto, H.1    Hasegawa, M.2    Ono, T.3    Xxxx, K.4    Xxxx, T.5    Ihara, Y.6    Miyamoto, E.7
  • 327
    • 0022633954 scopus 로고
    • Regional brain 5-hydroxytryptamine levels are reduced in senile Down's syndrome as in Alzheimer's disease
    • Yates C.M., Simpson J., Gordon A. Regional brain 5-hydroxytryptamine levels are reduced in senile Down's syndrome as in Alzheimer's disease. Neurosci. Lett. 1986, 11:189-192.
    • (1986) Neurosci. Lett. , vol.11 , pp. 189-192
    • Yates, C.M.1    Simpson, J.2    Gordon, A.3
  • 328
    • 0021049766 scopus 로고
    • Catecholamines and cholinergic enzymes in pre-senile and senile Alzheimer-type dementia and Down's syndrome
    • Yates C.M., Simpson J., Gordon A., Maloney A.F., Allison Y., Ritchie I.M., Urquhart A. Catecholamines and cholinergic enzymes in pre-senile and senile Alzheimer-type dementia and Down's syndrome. Brain Res. 1983, 280:119-126.
    • (1983) Brain Res. , vol.280 , pp. 119-126
    • Yates, C.M.1    Simpson, J.2    Gordon, A.3    Maloney, A.F.4    Allison, Y.5    Ritchie, I.M.6    Urquhart, A.7
  • 329
    • 33746216555 scopus 로고    scopus 로고
    • Inhibition of calcineurin by infusion of CsA causes hyperphosphorylation of tau and is accompanied by abnormal behavior in mice
    • Yu D.Y., Luo J., Bu F., Song G.J., Zhang L.Q., Wei Q. Inhibition of calcineurin by infusion of CsA causes hyperphosphorylation of tau and is accompanied by abnormal behavior in mice. J. Biol. Chem. 2006, 387:977-983.
    • (2006) J. Biol. Chem. , vol.387 , pp. 977-983
    • Yu, D.Y.1    Luo, J.2    Bu, F.3    Song, G.J.4    Zhang, L.Q.5    Wei, Q.6
  • 330
    • 0029900114 scopus 로고    scopus 로고
    • Developmental fates and migratory pathways of dividing progenitors in the postnatal rat cerebellum
    • Zhang L., Goldman J.E. Developmental fates and migratory pathways of dividing progenitors in the postnatal rat cerebellum. J. Comp. Neurol. 1996, 370:536-550.
    • (1996) J. Comp. Neurol. , vol.370 , pp. 536-550
    • Zhang, L.1    Goldman, J.E.2
  • 331
    • 0030025016 scopus 로고    scopus 로고
    • Generation of cerebellar interneurons from dividing progenitors in white matter
    • Zhang L., Goldman J.E. Generation of cerebellar interneurons from dividing progenitors in white matter. Neuron 1996, 16:47-54.
    • (1996) Neuron , vol.16 , pp. 47-54
    • Zhang, L.1    Goldman, J.E.2
  • 332
    • 0030022841 scopus 로고    scopus 로고
    • Prevalence of dementia in adults with and without Down syndrome
    • Zigman W.B., Schupf N., Sersen E., Silverman W. Prevalence of dementia in adults with and without Down syndrome. Am. J. Ment. Retard. 1996, 100:403-412.
    • (1996) Am. J. Ment. Retard. , vol.100 , pp. 403-412
    • Zigman, W.B.1    Schupf, N.2    Sersen, E.3    Silverman, W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.