Alterations of central noradrenergic transmission in Ts65Dn mouse, a model for Down syndrome

Brain Research

Volumn 749, Issue 2, 1997, Pages 238-244

  Dierssen, Mara ^a   Vallina, Iria F ^a   Baamonde, Carmela ^a   García Calatayud, Salvador ^a   Lumbreras, M Angeles ^a   Flórez, Jesús ^a  

^a UNIVERSITY OF CANTABRIA   (Spain)

Author keywords

adrenoceptor; cerebellum; cerebral cortex; Down syndrome; hippocampus; trisomic mouse

Indexed keywords

BETA ADRENERGIC RECEPTOR; CYCLIC AMP; FORSKOLIN; ISOPRENALINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN SLICE; CEREBELLUM; CONTROLLED STUDY; DOWN SYNDROME; HIPPOCAMPUS; MOUSE; MUTANT; NONHUMAN; NORADRENERGIC SYSTEM; PRIORITY JOURNAL; RECEPTOR BINDING;

1-METHYL-3-ISOBUTYLXANTHINE; ADRENERGIC BETA-AGONISTS; ANIMALS; BRAIN; CELL MEMBRANE; CEREBELLUM; CEREBRAL CORTEX; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 21; CYCLIC AMP; DOWN SYNDROME; FORSKOLIN; HIPPOCAMPUS; HUMANS; ISOPROTERENOL; KINETICS; MICE; MICE, NEUROLOGIC MUTANTS; NOREPINEPHRINE; ORGAN SPECIFICITY; PROPANOLAMINES; RECEPTORS, ADRENERGIC, BETA; REFERENCE VALUES; SIGNAL TRANSDUCTION;

EID: 0031055509     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(96)01173-0     Document Type: Article

References (36)

1. Becker, L., Mito, T., Takashima, S. and Onodera, K., Growth and development of the brain in Down syndrome. In C.J. Epstein (Ed.), The Morphogenesis of Down Syndrome, Wiley-Liss, New York, NY, 1991, pp. 133-152.
2. Brown, B.L., Albano, J.D.M., Elkins, R.P. and Sgherzi, A.M., A simple and sensitive saturation assay method for the measurement of adenosine 3′,5′-cyclic monophosphate, Biochem. J., 121 (1971) 561-562.
3. Byrne, J.H., Zwarties, R., Homayouni, R., Critz, S.D. and Eskin, A., Roles of second messenger pathways in neural plasticity and in learning and memory. Insights gained from Aplysia, In S. Shenolikar and A.C. Nairn (Eds.), Advances in Second Messenger and Phosphoprotein Research, Raven Press, New York, NY, 1993, pp. 47-108.
4. Coussons-Read, M.E. and Crnic, L.S., Behavioral assessment of the Ts65Dn mouse, a model for Down syndrome: altered behavior in the elevated plus maze and open field, Behav. Genet., 26 (1996) 7-13.
5. Davisson, M.T., Schmidt, C. and Akeson, E.C., Segmental trisomy murine chromosome 16: a new model for studying Down syndrome. In C.J. Epstein (Ed.), Molecular Genetics of Chromosome 21 and Down Syndrome, Wiley-Liss, New York, NY, 1990, pp. 263-380.
6. Davisson, M.T., Schmidt, C., Reeves, R.H., Irving, N.G., Akeson, E.C., Harris, B.S. and Bronson, R.T., Segmental trisomy as a mouse model for Down syndrome. In C.J. Epstein (Ed.), The Phenotypic Mapping of Down Syndrome and Other Aneuploid Conditions, Wiley-Liss, New York, NY, 1993, pp. 117-133.
7. Dierssen, M., Vallina, I.F., Baamonde, C., Lumbreras, M.A., Martínez-Cué, C., Calatayud, S.G. and Flórez, J., Impaired cyclic AMP production in the hippocampus of a Down syndrome murine model, Dev. Brain Res., 95 (1996) 122-124.
8. Duncan, G.E., Paul, J.A., Harden, T.K., Mueller, R.A. and Stumpf, W.E., Rapid down-regulation of β-adrenergic receptor by combining antidepressant drugs with forced swim: a model of antidepressant-induced neural adaptation, J. Pharmacol. Exp. Ther., 234 (1985) 402-408.
9. Epstein, C.J., Cox, D.R. and Epstein, L.B., Mouse trisomy 16: an animal model for trisomy 21 (Down's syndrome), Am. N.Y. Acad. Sci., 450 (1985) 157-177.
10. Epstein, C.J., Trisomy 21 and the nervous system: from cause to cure. In C.J. Epstein (Ed.), The Neurobiology of Down Syndrome, Raven Press, New York, NY, 1986, pp. 1-15.
11. Epstein, C.J., Berger, C.N., Carlson, E.J., Chan, P.H. and Hwang, T.T., Models for Down syndrome: chromosome 21-specific genes in mice. In D. Patterson and C.J. Epstein (Eds.), Molecular Genetics of Chromosome 21 and Down Syndrome, Wiley-Liss, New York, NY, 1990, pp. 215-232.
12. Escorihuela, R.M., Fernández-Teruel, A., Vallina, I.F., Baamonde, C., Lumbreras, M.A., Dierssen, M., Tobeña, A. and Flórez, J., A behavioral assessment of Ts65Dn mice: a putative Down syndrome model, Neurosci. Lett., 199 81995) 143-146.
13. Flórez, J., Neurologic abnormalities. In Pueschel, S.M. and Pueschel, J.K. (Eds.), Biomedical Concerns in Persons with Down Syndrome, Paul H. Brooks, Baltimore, MD, 1992, pp. 159-173.
14. Friedrich, P., Protein structure: the primary substrate for memory, Neuroscience, 35 (1990) 1-7.
15. Groner, Y., Elroy-Stein, O., Avraham, K.B., Yarom, R., Schickler, M., Knobler, H. and Rotman G., Down syndrome clinical symptoms are manifested in tranfected cells and transgenic mice overexpressing the human Cu/Zn-superoxide dismutase gene, J. Physiol. (Paris), 84 (1990) 53-77.
16. Holtzman, D.M., Killbridge, J., Chen, K.S., Rabin, J., Luche, R., Carlson, e., Epstein, C.J. and Mobley, W.C., Preliminary characterization of the central nervous system in partial trisomy 16 mice. In C.J. Epstein, T. Hassold, I.T., Lott, L. Nadel and D. Patterson (Eds.), Etiology and Pathogenesis of Down Syndrome, Wiley-Liss, New York, NY, 1995, pp. 227-240.
17. Hunter, A. and Steward, M.G., Long-term increases in the numerical density of synapses in the chick lobus paraolfactorius after passive avoidance training, Brain Res., 605 (1993) 251-255.
18. Kaufmann, W.E., Mental reatardation and learning dissorders: a neuropathologic differentiation. In A.J. Capute and P.J. Accardo (Eds.), Developmental Disabilities in Infancy and Childhood, Vol. 2, 2nd Ed., Paul, H. Brookes, Baltimore, MD, 1996, pp. 46-70.
19. Koistinaho, J., Hervonene, A., Winking, H. and Rapoport, S.I., Histochemically demonstrable catecholamines in the sympathetic nervous system of trisomy 16 and normal fetal mice, Mech. Age Dev., 57 (1991) 101-110.
20. Lake, C.R., Ziegler, M.G., Coleman, M. and Kopin., I.J., Evaluation of the sympathetic nervous system in trisomy 21 (Down's syndrome), J. Psychiatr. Res., 15 (1979) 1-6.
21. Lowry, O.H., Rosebrough, N.J., Farr, A.L. and Randall, R.J., Protein measurement with the Folin phenol reagent, J. Biol. Chem., 193 (1951) 265-275.
22. Mann. D.M.A., Lincoln, J., Yates, P.O. and Brennan, C.M., Monoamine metabolism in Down syndrome, Lancet, 2 (1980) 1366-1367.
23. McGeer, E.G., Norman, M., Boyes, B., O'Kusky, J., Suzuki, J. and McGeer, P.L., Acetylcholine and aromatic amine systems in postmortem brain of an infant with Down syndrome, Exp. Neurol., 87 (1985) 557-570.
24. McSwigan, J.D., Hanson, D.R., Lubiniecki, A., Heston, L.L. and Shepard, J.R., Down syndrome fibroblasts are hyperresponsive to β-adrenergic stimulation, Proc. Natl. Acad. Sci. USA, 78 (1981) 7670-7673.
25. Munson, P.J. and Rodbard, D., LIGAND: a versatile computerized approach for the characterization of ligand binding systems, Anal. Biochem., 107 (1980) 220-239.
26. Nyberg, P., Carlsson, A. and Winblad, B., Brain monoamines in cases with Down's syndrome without dementia, J. Neural Transm., 55 (1982) 289-299.
27. Oster-Granite, M.L., Gearhart, J.D. and Reeves, R.H., Neurobiological consequences of trisomy 16 mice. In C.J. Epstein (Ed.), The Neurobiology of Down Syndrome, Raven Press, New York. NY, 1986, pp. 137-155.
28. Ozand, P.T., Hawkins, R.L., Collins, R.M.Jr., Reed, W.D., Baab, P.J. and Oster-Granite, M.L., Neurochemical changes in murine trisomy 16: delay in cholinergic and catecholaminergic systems. J. Neurochem., 43 (1984) 401-408.
29. Reeves, R.H., Irving, N.G., Moran, T.H., Wohn, A., Kitt, C., Sisodia, S.S., Schmidt, C., Bronson, R.T. and Davisson, M.T., A mouse model for Down syndrome exhibits learning and behavioral deficits, Nature Genet., 11 (1995) 177-184.
30. Riolobos, A.S., Criado, J.M., de la Fuente, A. and Yajeya, J., Changes in the unitary activity of the basolateral amygdaloid nu-cleus of the rat after application of a foot-shock, Neurosci. Res. Commun., 12 (1993) 93-101.
31. Saltarelli, M.D., Forloni, G.L., Oster-Granite, M.L., Gearhart, J.D. and Coyle, J.T., Neurochemical characterization of embryonic brain development in trisomy 19 (ts19) mice: implication of selective deficits observed for abnormal neuronal development in aneuploidy, Dev. Genet., 8 (1987) 267-279.
32. Singer, H.S., Tiemeyer, M., Hedreen, J.C., Gearhart, J. and Coyle, J.T., Morphologic and neurochemical studies of embryonic brain development in murine trisomy 16, Dev. Brain Res., 15 (1984) 155-166.
33. Tovey, K.C., Oldham, K.G. and Whelan, J.A.M., A single direct assay for cyclic AMP in plasma and other biological samples using an improved competitive binding technique, Clin. Chem. Acta, 56 (1974) 221.
34. Uecker, A., Mangan, P.A., Obrzut, J.E. and Nadel, L., Down syndrome in neurobiological perspective: an emphasis on spatial cognition, J. Clin. Child Psychol., 26 (1993) 266-276.
35. Yates, C.M., Simpson, J., Gordon, A., Maloney, A.F.J., Allison, Y., Ritchie, I.M. and Urguhart, A., Catecholaminergic and cholinergic enzymes in presenile and senile Alzheimer's like disease and Down syndrome, Brain Res., 280 (1983) 119-126.
36. Wisniewski, K.E., Laure-Kaminowska, M., Connell, F. and Wen, C.Y., Neuronal density and synaptogenesis in postnatal stage of brain maduration in Down syndrome. In C.J. Epstein (Ed.), The Neurobiology of Down Syndrome, Raven Press, New York, NY, 1986, pp. 29-44.