Mild impairment of learning and memory in mice overexpressing the mSim2 gene located on chromosome 16: An animal model of Down's syndrome

Human Molecular Genetics

Volumn 8, Issue 8, 1999, Pages 1409-1415

  Ema, Masatsugu ^a   Ikegami, Shiro ^b   Hosoya, Tomonori ^a   Mimura, Junsei ^a   Ohtani, Haruo ^d   Nakao, Kazuki ^c   Inokuchi, Kaoru ^b   Katsuki, Motoya ^c   Fujii Kuriyama, Yoshiaki ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b MITSUBISHI KASEI INST OF LIFE SCI   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ACTIN; GENE PRODUCT; MESSENGER RNA;

AMNESIA; AMYGDALOID NUCLEUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN DEVELOPMENT; CHROMOSOME 16; CONTROLLED STUDY; DOWN SYNDROME; FEAR; GENE EXPRESSION; GENE LOCATION; GENE OVEREXPRESSION; HEART DEVELOPMENT; HIPPOCAMPUS; LEARNING DISORDER; MALE; MAZE TEST; MENTAL DEFICIENCY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BEHAVIOR, ANIMAL; CHROMOSOMES; CHROMOSOMES, HUMAN, PAIR 21; CONDITIONING (PSYCHOLOGY); DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; DOWN SYNDROME; DROSOPHILA PROTEINS; FEAR; GENE EXPRESSION REGULATION; GENOTYPE; HUMANS; LEARNING DISORDERS; MAZE LEARNING; MEMORY DISORDERS; MICE; MICE, TRANSGENIC; MOTOR ACTIVITY; NUCLEAR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SWIMMING; TISSUE DISTRIBUTION;

ANIMALIA; EUKARYOTA; MUS MUSCULUS; RODENTIA;

EID: 0032837516     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/8.8.1409     Document Type: Article

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