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Volumn 134, Issue 4, 2011, Pages 368-377

CD4 + T helper 2 cells - microbial triggers, differentiation requirements and effector functions

Author keywords

CD4 helper T cells (Th cells,Th0,Th1,Th2,Th3,TH17); T cells; T cell receptor

Indexed keywords

INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 9; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

EID: 80355124415     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2011.03497.x     Document Type: Review
Times cited : (45)

References (140)
  • 1
    • 0022640843 scopus 로고
    • Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
    • Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986; 136:2348-57.
    • (1986) J Immunol , vol.136 , pp. 2348-2357
    • Mosmann, T.R.1    Cherwinski, H.2    Bond, M.W.3    Giedlin, M.A.4    Coffman, R.L.5
  • 3
    • 56349154943 scopus 로고    scopus 로고
    • Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset
    • Veldhoen M, Uyttenhove C, van Snick J et al. Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat Immunol 2008; 9:1341-6.
    • (2008) Nat Immunol , vol.9 , pp. 1341-1346
    • Veldhoen, M.1    Uyttenhove, C.2    van Snick, J.3
  • 4
    • 77954948735 scopus 로고    scopus 로고
    • Effector T cell plasticity: flexibility in the face of changing circumstances
    • Murphy KM, Stockinger B. Effector T cell plasticity: flexibility in the face of changing circumstances. Nat Immunol 2011; 11:674-80.
    • (2011) Nat Immunol , vol.11 , pp. 674-680
    • Murphy, K.M.1    Stockinger, B.2
  • 5
    • 74549179138 scopus 로고    scopus 로고
    • + cell subset with combined Th2 and Th1 cell functions
    • + cell subset with combined Th2 and Th1 cell functions. Immunity 2010; 32:116-28.
    • (2010) Immunity , vol.32 , pp. 116-128
    • Hegazy, A.N.1    Peine, M.2    Helmstetter, C.3
  • 6
    • 78149326083 scopus 로고    scopus 로고
    • H2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma
    • H2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma. J Exp Med 2010; 207:2479-91.
    • (2010) J Exp Med , vol.207 , pp. 2479-2491
    • Wang, Y.H.1    Voo, K.S.2    Liu, B.3
  • 8
    • 0023913458 scopus 로고
    • + T cells in the IgE response and immunity to Nippostrongylus brasiliensis
    • + T cells in the IgE response and immunity to Nippostrongylus brasiliensis. J Immunol 1988; 140:3206-11.
    • (1988) J Immunol , vol.140 , pp. 3206-3211
    • Katona, I.M.1    Urban Jr, J.F.2    Finkelman, F.D.3
  • 11
    • 0034162535 scopus 로고    scopus 로고
    • Stat6 regulation of in vivo IL-4 responses
    • Finkelman FD, Morris SC, Orekhova T et al. Stat6 regulation of in vivo IL-4 responses. J Immunol 2000; 164:2303-10.
    • (2000) J Immunol , vol.164 , pp. 2303-2310
    • Finkelman, F.D.1    Morris, S.C.2    Orekhova, T.3
  • 13
    • 8644220507 scopus 로고    scopus 로고
    • Molecular analysis of a locus control region in the T helper 2 cytokine gene cluster: a target for STAT6 but not GATA3
    • Lee DU, Rao A. Molecular analysis of a locus control region in the T helper 2 cytokine gene cluster: a target for STAT6 but not GATA3. Proc Natl Acad Sci U S A 2004; 101:16010-5.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 16010-16015
    • Lee, D.U.1    Rao, A.2
  • 15
    • 25144476332 scopus 로고    scopus 로고
    • + T cells to generate a Th2-inducing cytokine environment
    • + T cells to generate a Th2-inducing cytokine environment. J Exp Med 2005; 202:793-804.
    • (2005) J Exp Med , vol.202 , pp. 793-804
    • Yamane, H.1    Zhu, J.2    Paul, W.E.3
  • 16
    • 4344647601 scopus 로고    scopus 로고
    • Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite
    • Min B, Prout M, Hu-Li J et al. Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite. J Exp Med 2004; 200:507-17.
    • (2004) J Exp Med , vol.200 , pp. 507-517
    • Min, B.1    Prout, M.2    Hu-Li, J.3
  • 17
    • 39449133957 scopus 로고    scopus 로고
    • A mechanism for the initiation of allergen-induced T helper type 2 responses
    • Sokol CL, Barton GM, Farr AG, Medzhitov R. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat Immunol 2008; 9:310-8.
    • (2008) Nat Immunol , vol.9 , pp. 310-318
    • Sokol, C.L.1    Barton, G.M.2    Farr, A.G.3    Medzhitov, R.4
  • 18
    • 79952741741 scopus 로고    scopus 로고
    • Basophils are the major producers of IL-4 during primary helminth infection
    • van Panhuys N, Prout M, Forbes E, Min B, Paul WE, Le Gros G. Basophils are the major producers of IL-4 during primary helminth infection. J Immunol 2011; 186:2719-28.
    • (2011) J Immunol , vol.186 , pp. 2719-2728
    • van Panhuys, N.1    Prout, M.2    Forbes, E.3    Min, B.4    Paul, W.E.5    Le Gros, G.6
  • 20
    • 67649216604 scopus 로고    scopus 로고
    • Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response
    • Sokol CL, Chu NQ, Yu S, Nish SA, Laufer TM, Medzhitov R. Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response. Nat Immunol 2009; 10:713-20.
    • (2009) Nat Immunol , vol.10 , pp. 713-720
    • Sokol, C.L.1    Chu, N.Q.2    Yu, S.3    Nish, S.A.4    Laufer, T.M.5    Medzhitov, R.6
  • 22
    • 63449108301 scopus 로고    scopus 로고
    • Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity
    • Ohnmacht C, Pullner A, King SB, Drexler I, Meier S, Brocker T, Voehringer D. Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity. J Exp Med 2009; 206:549-59.
    • (2009) J Exp Med , vol.206 , pp. 549-559
    • Ohnmacht, C.1    Pullner, A.2    King, S.B.3    Drexler, I.4    Meier, S.5    Brocker, T.6    Voehringer, D.7
  • 23
    • 77957020655 scopus 로고    scopus 로고
    • Basophils orchestrate chronic allergic dermatitis and protective immunity against helminths
    • Ohnmacht C, Schwartz C, Panzer M, Schiedewitz I, Naumann R, Voehringer D. Basophils orchestrate chronic allergic dermatitis and protective immunity against helminths. Immunity 2010; 33:364-74.
    • (2010) Immunity , vol.33 , pp. 364-374
    • Ohnmacht, C.1    Schwartz, C.2    Panzer, M.3    Schiedewitz, I.4    Naumann, R.5    Voehringer, D.6
  • 24
    • 77957731193 scopus 로고    scopus 로고
    • CD11c depletion severely disrupts Th2 induction and development in vivo
    • Phythian-Adams AT, Cook PC, Lundie RJ et al. CD11c depletion severely disrupts Th2 induction and development in vivo. J Exp Med 2010; 207:2089-96.
    • (2010) J Exp Med , vol.207 , pp. 2089-2096
    • Phythian-Adams, A.T.1    Cook, P.C.2    Lundie, R.J.3
  • 25
    • 77957745031 scopus 로고    scopus 로고
    • Inflammatory dendritic cells - not basophils - are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen
    • Hammad H, Plantinga M, Deswarte K, Pouliot P, Willart MA, Kool M, Muskens F, Lambrecht BN. Inflammatory dendritic cells - not basophils - are necessary and sufficient for induction of Th2 immunity to inhaled house dust mite allergen. J Exp Med 2010; 207:2097-111.
    • (2010) J Exp Med , vol.207 , pp. 2097-2111
    • Hammad, H.1    Plantinga, M.2    Deswarte, K.3    Pouliot, P.4    Willart, M.A.5    Kool, M.6    Muskens, F.7    Lambrecht, B.N.8
  • 27
    • 77953812779 scopus 로고    scopus 로고
    • The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling
    • Tang H, Cao W, Kasturi SP et al. The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling. Nat Immunol 2010; 11:608-17.
    • (2010) Nat Immunol , vol.11 , pp. 608-617
    • Tang, H.1    Cao, W.2    Kasturi, S.P.3
  • 30
    • 0028867420 scopus 로고
    • Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
    • Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone JA, Sharpe AH. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 1995; 3:541-7.
    • (1995) Immunity , vol.3 , pp. 541-547
    • Tivol, E.A.1    Borriello, F.2    Schweitzer, A.N.3    Lynch, W.P.4    Bluestone, J.A.5    Sharpe, A.H.6
  • 32
  • 33
    • 0033563265 scopus 로고    scopus 로고
    • Lymphoproliferative disorder in CTLA-4 knockout mice is characterized by CD28-regulated activation of Th2 responses
    • Khattri R, Auger JA, Griffin MD, Sharpe AH, Bluestone JA. Lymphoproliferative disorder in CTLA-4 knockout mice is characterized by CD28-regulated activation of Th2 responses. J Immunol 1999; 162:5784-91.
    • (1999) J Immunol , vol.162 , pp. 5784-5791
    • Khattri, R.1    Auger, J.A.2    Griffin, M.D.3    Sharpe, A.H.4    Bluestone, J.A.5
  • 36
    • 85047692516 scopus 로고    scopus 로고
    • Signalling pathways of the TNF superfamily: a double-edged sword
    • Aggarwal BB. Signalling pathways of the TNF superfamily: a double-edged sword. Nat Rev Immunol 2003; 3:745-56.
    • (2003) Nat Rev Immunol , vol.3 , pp. 745-756
    • Aggarwal, B.B.1
  • 37
    • 35748935554 scopus 로고    scopus 로고
    • Dendritic cell expression of OX40 ligand acts as a costimulatory, not polarizing, signal for optimal Th2 priming and memory induction in vivo
    • Jenkins SJ, Perona-Wright G, Worsley AG, Ishii N, MacDonald AS. Dendritic cell expression of OX40 ligand acts as a costimulatory, not polarizing, signal for optimal Th2 priming and memory induction in vivo. J Immunol 2007; 179:3515-23.
    • (2007) J Immunol , vol.179 , pp. 3515-3523
    • Jenkins, S.J.1    Perona-Wright, G.2    Worsley, A.G.3    Ishii, N.4    MacDonald, A.S.5
  • 39
    • 73949084268 scopus 로고    scopus 로고
    • GITR signaling potentiates airway hyperresponsiveness by enhancing Th2 cell activity in a mouse model of asthma
    • Motta AC, Vissers JL, Gras R, Van Esch BC, Van Oosterhout AJ, Nawijn MC. GITR signaling potentiates airway hyperresponsiveness by enhancing Th2 cell activity in a mouse model of asthma. Respir Res 2009; 10:93.
    • (2009) Respir Res , vol.10 , pp. 93
    • Motta, A.C.1    Vissers, J.L.2    Gras, R.3    Van Esch, B.C.4    Van Oosterhout, A.J.5    Nawijn, M.C.6
  • 40
    • 29744441207 scopus 로고    scopus 로고
    • Glucocorticoid-induced TNFR family-related protein (GITR) activation exacerbates murine asthma and collagen-induced arthritis
    • Patel M, Xu D, Kewin P, Choo-Kang B, McSharry C, Thomson NC, Liew FY. Glucocorticoid-induced TNFR family-related protein (GITR) activation exacerbates murine asthma and collagen-induced arthritis. Eur J Immunol 2005; 35:3581-90.
    • (2005) Eur J Immunol , vol.35 , pp. 3581-3590
    • Patel, M.1    Xu, D.2    Kewin, P.3    Choo-Kang, B.4    McSharry, C.5    Thomson, N.C.6    Liew, F.Y.7
  • 41
    • 34447634411 scopus 로고    scopus 로고
    • Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch
    • Amsen D, Antov A, Jankovic D et al. Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity 2007; 27:89-99.
    • (2007) Immunity , vol.27 , pp. 89-99
    • Amsen, D.1    Antov, A.2    Jankovic, D.3
  • 44
    • 41449093693 scopus 로고    scopus 로고
    • Human immature myeloid dendritic cells trigger a TH2-polarizing program via Jagged-1/Notch interaction
    • Liotta F, Frosali F, Querci V et al. Human immature myeloid dendritic cells trigger a TH2-polarizing program via Jagged-1/Notch interaction. J Allergy Clin Immunol 2008; 121:1000-5.
    • (2008) J Allergy Clin Immunol , vol.121 , pp. 1000-1005
    • Liotta, F.1    Frosali, F.2    Querci, V.3
  • 45
    • 78650642332 scopus 로고    scopus 로고
    • Notch ligand delta-like 4 regulates development and pathogenesis of allergic airway responses by modulating IL-2 production and Th2 immunity
    • Jang S, Schaller M, Berlin AA, Lukacs NW. Notch ligand delta-like 4 regulates development and pathogenesis of allergic airway responses by modulating IL-2 production and Th2 immunity. J Immunol 2010; 185:5835-44.
    • (2010) J Immunol , vol.185 , pp. 5835-5844
    • Jang, S.1    Schaller, M.2    Berlin, A.A.3    Lukacs, N.W.4
  • 46
    • 36549001590 scopus 로고    scopus 로고
    • Notch ligand Delta-like 4 regulates disease pathogenesis during respiratory viral infections by modulating Th2 cytokines
    • Schaller MA, Neupane R, Rudd BD et al. Notch ligand Delta-like 4 regulates disease pathogenesis during respiratory viral infections by modulating Th2 cytokines. J Exp Med 2007; 204:2925-34.
    • (2007) J Exp Med , vol.204 , pp. 2925-2934
    • Schaller, M.A.1    Neupane, R.2    Rudd, B.D.3
  • 47
    • 40749089559 scopus 로고    scopus 로고
    • Suppression of Th2 cell development by Notch ligands Delta1 and Delta4
    • Sun J, Krawczyk CJ, Pearce EJ. Suppression of Th2 cell development by Notch ligands Delta1 and Delta4. J Immunol 2008; 180:1655-61.
    • (2008) J Immunol , vol.180 , pp. 1655-1661
    • Sun, J.1    Krawczyk, C.J.2    Pearce, E.J.3
  • 49
    • 0030810155 scopus 로고    scopus 로고
    • The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells
    • Zheng W, Flavell RA. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 1997; 89:587-96.
    • (1997) Cell , vol.89 , pp. 587-596
    • Zheng, W.1    Flavell, R.A.2
  • 50
    • 1242274405 scopus 로고    scopus 로고
    • GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells
    • Pai SY, Truitt ML, Ho IC. GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells. Proc Natl Acad Sci U S A 2004; 101:1993-8.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 1993-1998
    • Pai, S.Y.1    Truitt, M.L.2    Ho, I.C.3
  • 51
    • 33646196946 scopus 로고    scopus 로고
    • Regulation of Th2 differentiation and Il4 locus accessibility
    • Ansel KM, Djuretic I, Tanasa B, Rao A. Regulation of Th2 differentiation and Il4 locus accessibility. Annu Rev Immunol 2006; 24:607-56.
    • (2006) Annu Rev Immunol , vol.24 , pp. 607-656
    • Ansel, K.M.1    Djuretic, I.2    Tanasa, B.3    Rao, A.4
  • 52
    • 79960035010 scopus 로고    scopus 로고
    • An updated view on transcription factor GATA3-mediated regulation of Th1 and Th2 cell differentiation
    • Yagi R, Zhu J, Paul WE. An updated view on transcription factor GATA3-mediated regulation of Th1 and Th2 cell differentiation. Int Immunol 2011; 23:415-20.
    • (2011) Int Immunol , vol.23 , pp. 415-420
    • Yagi, R.1    Zhu, J.2    Paul, W.E.3
  • 53
    • 0028177589 scopus 로고
    • CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3
    • Yoshimoto T, Paul WE. CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J Exp Med 1994; 179:1285-95.
    • (1994) J Exp Med , vol.179 , pp. 1285-1295
    • Yoshimoto, T.1    Paul, W.E.2
  • 54
    • 0025753325 scopus 로고
    • Mouse splenic and bone marrow cell populations that express high-affinity Fc epsilon receptors and produce interleukin 4 are highly enriched in basophils
    • Seder RA, Paul WE, Dvorak AM et al. Mouse splenic and bone marrow cell populations that express high-affinity Fc epsilon receptors and produce interleukin 4 are highly enriched in basophils. Proc Natl Acad Sci U S A 1991; 88:2835-9.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 2835-2839
    • Seder, R.A.1    Paul, W.E.2    Dvorak, A.M.3
  • 55
    • 77249158040 scopus 로고    scopus 로고
    • Cutting edge: basophils are transiently recruited into the draining lymph nodes during helminth infection via IL-3, but infection-induced Th2 immunity can develop without basophil lymph node recruitment or IL-3
    • Kim S, Prout M, Ramshaw H, Lopez AF, LeGros G, Min B. Cutting edge: basophils are transiently recruited into the draining lymph nodes during helminth infection via IL-3, but infection-induced Th2 immunity can develop without basophil lymph node recruitment or IL-3. J Immunol 2010; 184:1143-7.
    • (2010) J Immunol , vol.184 , pp. 1143-1147
    • Kim, S.1    Prout, M.2    Ramshaw, H.3    Lopez, A.F.4    LeGros, G.5    Min, B.6
  • 56
    • 50449101434 scopus 로고    scopus 로고
    • In vivo studies fail to reveal a role for IL-4 or STAT6 signaling in Th2 lymphocyte differentiation
    • van Panhuys N, Tang SC, Prout M et al. In vivo studies fail to reveal a role for IL-4 or STAT6 signaling in Th2 lymphocyte differentiation. Proc Natl Acad Sci U S A 2008; 105:12423-8.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 12423-12428
    • van Panhuys, N.1    Tang, S.C.2    Prout, M.3
  • 57
    • 0036301998 scopus 로고    scopus 로고
    • Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP
    • Soumelis V, Reche PA, Kanzler H et al. Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat Immunol 2002; 3:673-80.
    • (2002) Nat Immunol , vol.3 , pp. 673-680
    • Soumelis, V.1    Reche, P.A.2    Kanzler, H.3
  • 58
    • 79955143880 scopus 로고    scopus 로고
    • Thymic stromal lymphopoietin is expressed and produced by caspase-1/NF-kappaB pathway in mast cells
    • Moon PD, Kim HM. Thymic stromal lymphopoietin is expressed and produced by caspase-1/NF-kappaB pathway in mast cells. Cytokine 2011; 54:239-43.
    • (2011) Cytokine , vol.54 , pp. 239-243
    • Moon, P.D.1    Kim, H.M.2
  • 60
    • 25844515028 scopus 로고    scopus 로고
    • Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice
    • Zhou B, Comeau MR, De Smedt T et al. Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice. Nat Immunol 2005; 6:1047-53.
    • (2005) Nat Immunol , vol.6 , pp. 1047-1053
    • Zhou, B.1    Comeau, M.R.2    De Smedt, T.3
  • 61
    • 34548713042 scopus 로고    scopus 로고
    • TLR3- and Th2 cytokine-dependent production of thymic stromal lymphopoietin in human airway epithelial cells
    • Kato A, Favoreto S Jr, Avila PC, Schleimer RP. TLR3- and Th2 cytokine-dependent production of thymic stromal lymphopoietin in human airway epithelial cells. J Immunol 2007; 179:1080-7.
    • (2007) J Immunol , vol.179 , pp. 1080-1087
    • Kato, A.1    Favoreto Jr, S.2    Avila, P.C.3    Schleimer, R.P.4
  • 62
    • 27744510433 scopus 로고    scopus 로고
    • TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand
    • Ito T, Wang YH, Duramad O et al. TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand. J Exp Med 2005; 202:1213-23.
    • (2005) J Exp Med , vol.202 , pp. 1213-1223
    • Ito, T.1    Wang, Y.H.2    Duramad, O.3
  • 64
  • 67
    • 79957609041 scopus 로고    scopus 로고
    • Diversity and dialogue in immunity to helminths
    • Allen JE, Maizels RM. Diversity and dialogue in immunity to helminths. Nat Rev Immunol 2011; 11:375-88.
    • (2011) Nat Rev Immunol , vol.11 , pp. 375-388
    • Allen, J.E.1    Maizels, R.M.2
  • 68
    • 66149113689 scopus 로고    scopus 로고
    • Thymic stromal lymphopoietin, OX40-ligand, and interleukin-25 in allergic responses
    • Wang YH, Liu YJ. Thymic stromal lymphopoietin, OX40-ligand, and interleukin-25 in allergic responses. Clin Exp Allergy 2009; 39:798-806.
    • (2009) Clin Exp Allergy , vol.39 , pp. 798-806
    • Wang, Y.H.1    Liu, Y.J.2
  • 69
    • 77956404942 scopus 로고    scopus 로고
    • Protease allergens induce the expression of IL-25 via Erk and p38 MAPK pathway
    • Yu HS, Angkasekwinai P, Chang SH, Chung Y, Dong C. Protease allergens induce the expression of IL-25 via Erk and p38 MAPK pathway. J Korean Med Sci 2010; 25:829-34.
    • (2010) J Korean Med Sci , vol.25 , pp. 829-834
    • Yu, H.S.1    Angkasekwinai, P.2    Chang, S.H.3    Chung, Y.4    Dong, C.5
  • 71
    • 33645888708 scopus 로고    scopus 로고
    • Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion
    • Fallon PG, Ballantyne SJ, Mangan NE et al. Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion. J Exp Med 2006; 203:1105-16.
    • (2006) J Exp Med , vol.203 , pp. 1105-1116
    • Fallon, P.G.1    Ballantyne, S.J.2    Mangan, N.E.3
  • 72
    • 33645896155 scopus 로고    scopus 로고
    • Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract
    • Owyang AM, Zaph C, Wilson EH et al. Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract. J Exp Med 2006; 203:843-9.
    • (2006) J Exp Med , vol.203 , pp. 843-849
    • Owyang, A.M.1    Zaph, C.2    Wilson, E.H.3
  • 73
    • 18244405108 scopus 로고    scopus 로고
    • IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo
    • Fort MM, Cheung J, Yen D et al. IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo. Immunity 2001; 15:985-95.
    • (2001) Immunity , vol.15 , pp. 985-995
    • Fort, M.M.1    Cheung, J.2    Yen, D.3
  • 74
    • 34547820890 scopus 로고    scopus 로고
    • IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells
    • Wang YH, Angkasekwinai P, Lu N et al. IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells. J Exp Med 2007; 204:1837-47.
    • (2007) J Exp Med , vol.204 , pp. 1837-1847
    • Wang, Y.H.1    Angkasekwinai, P.2    Lu, N.3
  • 75
    • 77951817855 scopus 로고    scopus 로고
    • Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
    • Neill DR, Wong SH, Bellosi A et al. Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature 2010; 464:1367-70.
    • (2010) Nature , vol.464 , pp. 1367-1370
    • Neill, D.R.1    Wong, S.H.2    Bellosi, A.3
  • 79
    • 78650642300 scopus 로고    scopus 로고
    • Critical role of IL-25 in nematode infection-induced alterations in intestinal function
    • Zhao A, Urban JF Jr, Sun R et al. Critical role of IL-25 in nematode infection-induced alterations in intestinal function. J Immunol 2010; 185:6921-9.
    • (2010) J Immunol , vol.185 , pp. 6921-6929
    • Zhao, A.1    Urban Jr, J.F.2    Sun, R.3
  • 80
    • 79955082903 scopus 로고    scopus 로고
    • Nuocytes and beyond: new insights into helminth expulsion
    • Neill DR, McKenzie AN. Nuocytes and beyond: new insights into helminth expulsion. Trends Parasitol 2011; 27:214-21.
    • (2011) Trends Parasitol , vol.27 , pp. 214-221
    • Neill, D.R.1    McKenzie, A.N.2
  • 81
    • 79952531912 scopus 로고    scopus 로고
    • Type 2 innate immune responses and the natural helper cell
    • Koyasu S, Moro K. Type 2 innate immune responses and the natural helper cell. Immunology 2011; 132:475-81.
    • (2011) Immunology , vol.132 , pp. 475-481
    • Koyasu, S.1    Moro, K.2
  • 82
    • 44849117539 scopus 로고    scopus 로고
    • Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system
    • Kondo Y, Yoshimoto T, Yasuda K et al. Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system. Int Immunol 2008; 20:791-800.
    • (2008) Int Immunol , vol.20 , pp. 791-800
    • Kondo, Y.1    Yoshimoto, T.2    Yasuda, K.3
  • 83
    • 58149300244 scopus 로고    scopus 로고
    • + T cells and promotes allergic-induced airway inflammation independent of IL-4
    • + T cells and promotes allergic-induced airway inflammation independent of IL-4. J Immunol 2008; 181:4780-90.
    • (2008) J Immunol , vol.181 , pp. 4780-4790
    • Kurowska-Stolarska, M.1    Kewin, P.2    Murphy, G.3
  • 84
    • 27744446058 scopus 로고    scopus 로고
    • IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines
    • Schmitz J, Owyang A, Oldham E et al. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 2005; 23:479-90.
    • (2005) Immunity , vol.23 , pp. 479-490
    • Schmitz, J.1    Owyang, A.2    Oldham, E.3
  • 85
    • 37249049230 scopus 로고    scopus 로고
    • IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcepsilonRI signals
    • Ho LH, Ohno T, Oboki K et al. IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcepsilonRI signals. J Leukoc Biol 2007; 82:1481-90.
    • (2007) J Leukoc Biol , vol.82 , pp. 1481-1490
    • Ho, L.H.1    Ohno, T.2    Oboki, K.3
  • 86
    • 70049104738 scopus 로고    scopus 로고
    • IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88- and p38alpha-dependent pathway
    • Kroeger KM, Sullivan BM, Locksley RM. IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88- and p38alpha-dependent pathway. J Leukoc Biol 2009; 86:769-78.
    • (2009) J Leukoc Biol , vol.86 , pp. 769-778
    • Kroeger, K.M.1    Sullivan, B.M.2    Locksley, R.M.3
  • 87
    • 70349337464 scopus 로고    scopus 로고
    • IL-33 activates unprimed murine basophils directly in vitro and induces their in vivo expansion indirectly by promoting hematopoietic growth factor production
    • Schneider E, Petit-Bertron AF, Bricard R, Levasseur M, Ramadan A, Girard JP, Herbelin A, Dy M. IL-33 activates unprimed murine basophils directly in vitro and induces their in vivo expansion indirectly by promoting hematopoietic growth factor production. J Immunol 2009; 183:3591-7.
    • (2009) J Immunol , vol.183 , pp. 3591-3597
    • Schneider, E.1    Petit-Bertron, A.F.2    Bricard, R.3    Levasseur, M.4    Ramadan, A.5    Girard, J.P.6    Herbelin, A.7    Dy, M.8
  • 89
    • 69449106110 scopus 로고    scopus 로고
    • IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells
    • Guo L, Wei G, Zhu J, Liao W, Leonard WJ, Zhao K, Paul W. IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proc Natl Acad Sci U S A 2009; 106:13463-8.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 13463-13468
    • Guo, L.1    Wei, G.2    Zhu, J.3    Liao, W.4    Leonard, W.J.5    Zhao, K.6    Paul, W.7
  • 90
    • 0033523665 scopus 로고    scopus 로고
    • Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses
    • Coyle AJ, Lloyd C, Tian J et al. Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses. J Exp Med 1999; 190:895-902.
    • (1999) J Exp Med , vol.190 , pp. 895-902
    • Coyle, A.J.1    Lloyd, C.2    Tian, J.3
  • 91
    • 0037378857 scopus 로고    scopus 로고
    • Signaling through the T1/ST2 molecule is not necessary for Th2 differentiation but is important for the regulation of type 1 responses in nonhealing Leishmania major infection
    • Kropf P, Herath S, Klemenz R, Muller I. Signaling through the T1/ST2 molecule is not necessary for Th2 differentiation but is important for the regulation of type 1 responses in nonhealing Leishmania major infection. Infect Immun 2003; 71:1961-71.
    • (2003) Infect Immun , vol.71 , pp. 1961-1971
    • Kropf, P.1    Herath, S.2    Klemenz, R.3    Muller, I.4
  • 92
    • 0034689033 scopus 로고    scopus 로고
    • T1/ST2-deficient mice demonstrate the importance of T1/ST2 in developing primary T helper cell type 2 responses
    • Townsend MJ, Fallon PG, Matthews DJ, Jolin HE, McKenzie AN. T1/ST2-deficient mice demonstrate the importance of T1/ST2 in developing primary T helper cell type 2 responses. J Exp Med 2000; 191:1069-76.
    • (2000) J Exp Med , vol.191 , pp. 1069-1076
    • Townsend, M.J.1    Fallon, P.G.2    Matthews, D.J.3    Jolin, H.E.4    McKenzie, A.N.5
  • 93
    • 0033570791 scopus 로고    scopus 로고
    • The absence of interleukin 1 receptor-related T1/ST2 does not affect T helper cell type 2 development and its effector function
    • Hoshino K, Kashiwamura S, Kuribayashi K et al. The absence of interleukin 1 receptor-related T1/ST2 does not affect T helper cell type 2 development and its effector function. J Exp Med 1999; 190:1541-8.
    • (1999) J Exp Med , vol.190 , pp. 1541-1548
    • Hoshino, K.1    Kashiwamura, S.2    Kuribayashi, K.3
  • 94
    • 79955509396 scopus 로고    scopus 로고
    • Endogenous IL-33 enhances Th2 cytokine production and T-cell responses during allergic airway inflammation
    • Louten J, Rankin AL, Li Y et al. Endogenous IL-33 enhances Th2 cytokine production and T-cell responses during allergic airway inflammation. Int Immunol 2011; 23:307-15.
    • (2011) Int Immunol , vol.23 , pp. 307-315
    • Louten, J.1    Rankin, A.L.2    Li, Y.3
  • 95
    • 14044257261 scopus 로고    scopus 로고
    • Variegation of the immune response with dendritic cells and pathogen recognition receptors
    • Pulendran B. Variegation of the immune response with dendritic cells and pathogen recognition receptors. J Immunol 2005; 174:2457-65.
    • (2005) J Immunol , vol.174 , pp. 2457-2465
    • Pulendran, B.1
  • 96
    • 0742272509 scopus 로고    scopus 로고
    • Toll-like receptors and dendritic cells: for whom the bug tolls
    • Reis e Sousa C. Toll-like receptors and dendritic cells: for whom the bug tolls. Semin Immunol 2004; 16:27-34.
    • (2004) Semin Immunol , vol.16 , pp. 27-34
    • Reis e Sousa, C.1
  • 97
    • 3042521047 scopus 로고    scopus 로고
    • Modulating TH1/TH2 responses with microbes, dendritic cells, and pathogen recognition receptors
    • Pulendran B. Modulating TH1/TH2 responses with microbes, dendritic cells, and pathogen recognition receptors. Immunol Res 2004; 3:187-96.
    • (2004) Immunol Res , vol.3 , pp. 187-196
    • Pulendran, B.1
  • 98
    • 0344153910 scopus 로고    scopus 로고
    • Maturation of dendritic cell 2 phenotype by a helminth glycan uses a Toll-like receptor 4-dependent mechanism
    • Thomas PG, Carter MR, Atochina O, Da'dara AA, Piskorska D, McGuire E, Harn DA. Maturation of dendritic cell 2 phenotype by a helminth glycan uses a Toll-like receptor 4-dependent mechanism. J Immunol 2003; 171:5837-41.
    • (2003) J Immunol , vol.171 , pp. 5837-5841
    • Thomas, P.G.1    Carter, M.R.2    Atochina, O.3    Da'dara, A.A.4    Piskorska, D.5    McGuire, E.6    Harn, D.A.7
  • 99
    • 77953299188 scopus 로고    scopus 로고
    • Helminths and dendritic cells: sensing and regulating via pattern recognition receptors, Th2 and Treg responses
    • Everts B, Smits HH, Hokke CH, Yazdanbakhsh M. Helminths and dendritic cells: sensing and regulating via pattern recognition receptors, Th2 and Treg responses. Eur J Immunol 2010; 40:1525-37.
    • (2010) Eur J Immunol , vol.40 , pp. 1525-1537
    • Everts, B.1    Smits, H.H.2    Hokke, C.H.3    Yazdanbakhsh, M.4
  • 100
    • 68149156007 scopus 로고    scopus 로고
    • Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses
    • Everts B, Perona-Wright G, Smits HH et al. Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses. J Exp Med 2009; 206:1673-80.
    • (2009) J Exp Med , vol.206 , pp. 1673-1680
    • Everts, B.1    Perona-Wright, G.2    Smits, H.H.3
  • 101
    • 33645846029 scopus 로고    scopus 로고
    • IPSE/alpha-1: a major immunogenic component secreted from Schistosoma mansoni eggs
    • Schramm G, Gronow A, Knobloch J et al. IPSE/alpha-1: a major immunogenic component secreted from Schistosoma mansoni eggs. Mol Biochem Parasitol 2006; 147:9-19.
    • (2006) Mol Biochem Parasitol , vol.147 , pp. 9-19
    • Schramm, G.1    Gronow, A.2    Knobloch, J.3
  • 102
    • 68149163162 scopus 로고    scopus 로고
    • The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1)
    • Steinfelder S, Andersen JF, Cannons JL et al. The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1). J Exp Med 2009; 206:1681-90.
    • (2009) J Exp Med , vol.206 , pp. 1681-1690
    • Steinfelder, S.1    Andersen, J.F.2    Cannons, J.L.3
  • 103
    • 33646265778 scopus 로고    scopus 로고
    • IPSE/alpha-1, a major secretory glycoprotein antigen from schistosome eggs, expresses the Lewis X motif on core-difucosylated N-glycans
    • Wuhrer M, Balog CI, Catalina MI et al. IPSE/alpha-1, a major secretory glycoprotein antigen from schistosome eggs, expresses the Lewis X motif on core-difucosylated N-glycans. FEBS J 2006; 273:2276-92.
    • (2006) FEBS J , vol.273 , pp. 2276-2292
    • Wuhrer, M.1    Balog, C.I.2    Catalina, M.I.3
  • 104
    • 33846918192 scopus 로고    scopus 로고
    • Schistosoma mansoni soluble egg antigens are internalized by human dendritic cells through multiple C-type lectins and suppress TLR-induced dendritic cell activation
    • van Liempt E, van Vliet SJ, Engering A, Garcia Vallejo JJ, Bank CM, Sanchez-Hernandez M, van Kooyk Y, van DI. Schistosoma mansoni soluble egg antigens are internalized by human dendritic cells through multiple C-type lectins and suppress TLR-induced dendritic cell activation. Mol Immunol 2007; 44:2605-15.
    • (2007) Mol Immunol , vol.44 , pp. 2605-2615
    • van Liempt, E.1    van Vliet, S.J.2    Engering, A.3    Garcia Vallejo, J.J.4    Bank, C.M.5    Sanchez-Hernandez, M.6    van Kooyk, Y.7    van, D.I.8
  • 105
    • 60949099835 scopus 로고    scopus 로고
    • Calreticulin from the intestinal nematode Heligmosomoides polygyrus is a Th2-skewing protein and interacts with murine scavenger receptor-A
    • Rzepecka J, Rausch S, Klotz C et al. Calreticulin from the intestinal nematode Heligmosomoides polygyrus is a Th2-skewing protein and interacts with murine scavenger receptor-A. Mol Immunol 2009; 46:1109-19.
    • (2009) Mol Immunol , vol.46 , pp. 1109-1119
    • Rzepecka, J.1    Rausch, S.2    Klotz, C.3
  • 106
    • 9244249137 scopus 로고    scopus 로고
    • Selective maturation of dendritic cells by Nippostrongylus brasiliensis-secreted proteins drives Th2 immune responses
    • Balic A, Harcus Y, Holland MJ, Maizels RM. Selective maturation of dendritic cells by Nippostrongylus brasiliensis-secreted proteins drives Th2 immune responses. Eur J Immunol 2004; 34:3047-59.
    • (2004) Eur J Immunol , vol.34 , pp. 3047-3059
    • Balic, A.1    Harcus, Y.2    Holland, M.J.3    Maizels, R.M.4
  • 107
    • 0033922732 scopus 로고    scopus 로고
    • Proteins secreted by the parasitic nematode Nippostrongylus brasiliensis act as adjuvants for Th2 responses
    • Holland MJ, Harcus YM, Riches PL, Maizels RM. Proteins secreted by the parasitic nematode Nippostrongylus brasiliensis act as adjuvants for Th2 responses. Eur J Immunol 2000; 30:1977-87.
    • (2000) Eur J Immunol , vol.30 , pp. 1977-1987
    • Holland, M.J.1    Harcus, Y.M.2    Riches, P.L.3    Maizels, R.M.4
  • 108
    • 78149261083 scopus 로고    scopus 로고
    • Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-beta pathway
    • Grainger JR, Smith KA, Hewitson JP et al. Helminth secretions induce de novo T cell Foxp3 expression and regulatory function through the TGF-beta pathway. J Exp Med 2010; 207:2331-41.
    • (2010) J Exp Med , vol.207 , pp. 2331-2341
    • Grainger, J.R.1    Smith, K.A.2    Hewitson, J.P.3
  • 109
    • 33144476468 scopus 로고    scopus 로고
    • Regulatory T cells induced by parasites and the modulation of allergic responses
    • Wilson MS, Maizels RM. Regulatory T cells induced by parasites and the modulation of allergic responses. Chem Immunol Allergy 2006; 90:176-95.
    • (2006) Chem Immunol Allergy , vol.90 , pp. 176-195
    • Wilson, M.S.1    Maizels, R.M.2
  • 110
    • 58149242734 scopus 로고    scopus 로고
    • The danger within: endogenous danger signals, atopy and asthma
    • Willart MA, Lambrecht BN. The danger within: endogenous danger signals, atopy and asthma. Clin Exp Allergy 2009; 39:12-9.
    • (2009) Clin Exp Allergy , vol.39 , pp. 12-19
    • Willart, M.A.1    Lambrecht, B.N.2
  • 111
    • 59049100417 scopus 로고    scopus 로고
    • Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein
    • Trompette A, Divanovic S, Visintin A et al. Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein. Nature 2009; 457:585-8.
    • (2009) Nature , vol.457 , pp. 585-588
    • Trompette, A.1    Divanovic, S.2    Visintin, A.3
  • 112
    • 64149087970 scopus 로고    scopus 로고
    • House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells
    • Hammad H, Chieppa M, Perros F, Willart MA, Germain RN, Lambrecht BN. House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells. Nat Med 2009; 15:410-6.
    • (2009) Nat Med , vol.15 , pp. 410-416
    • Hammad, H.1    Chieppa, M.2    Perros, F.3    Willart, M.A.4    Germain, R.N.5    Lambrecht, B.N.6
  • 113
    • 79952313959 scopus 로고    scopus 로고
    • Mite allergen is a danger signal for the skin via activation of inflammasome in keratinocytes
    • Dai X, Sayama K, Tohyama M et al. Mite allergen is a danger signal for the skin via activation of inflammasome in keratinocytes. J Allergy Clin Immunol 2011; 127:806-14.
    • (2011) J Allergy Clin Immunol , vol.127 , pp. 806-814
    • Dai, X.1    Sayama, K.2    Tohyama, M.3
  • 114
    • 79955040263 scopus 로고    scopus 로고
    • The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses
    • Kouzaki H, Iijima K, Kobayashi T, O'Grady SM, Kita H. The danger signal, extracellular ATP, is a sensor for an airborne allergen and triggers IL-33 release and innate Th2-type responses. J Immunol 2011; 186:4375-87.
    • (2011) J Immunol , vol.186 , pp. 4375-4387
    • Kouzaki, H.1    Iijima, K.2    Kobayashi, T.3    O'Grady, S.M.4    Kita, H.5
  • 115
    • 77954311653 scopus 로고    scopus 로고
    • T-cell polarization depends on concentration of the danger signal used to activate dendritic cells
    • Peters M, Dudziak K, Stiehm M, Bufe A. T-cell polarization depends on concentration of the danger signal used to activate dendritic cells. Immunol Cell Biol 2010; 88:537-44.
    • (2010) Immunol Cell Biol , vol.88 , pp. 537-544
    • Peters, M.1    Dudziak, K.2    Stiehm, M.3    Bufe, A.4
  • 117
    • 65449144481 scopus 로고    scopus 로고
    • IL-1-dependent, IL-1R1-independent resistance to gastrointestinal nematodes
    • Humphreys NE, Grencis RK. IL-1-dependent, IL-1R1-independent resistance to gastrointestinal nematodes. Eur J Immunol 2009; 39:1036-45.
    • (2009) Eur J Immunol , vol.39 , pp. 1036-1045
    • Humphreys, N.E.1    Grencis, R.K.2
  • 118
    • 0037385617 scopus 로고    scopus 로고
    • IL-1 is required for allergen-specific Th2 cell activation and the development of airway hypersensitivity response
    • Nakae S, Komiyama Y, Yokoyama H et al. IL-1 is required for allergen-specific Th2 cell activation and the development of airway hypersensitivity response. Int Immunol 2003; 15:483-90.
    • (2003) Int Immunol , vol.15 , pp. 483-490
    • Nakae, S.1    Komiyama, Y.2    Yokoyama, H.3
  • 119
    • 66149171633 scopus 로고    scopus 로고
    • Purinergic signaling and immune modulation at the schistosome surface?
    • Bhardwaj R, Skelly PJ. Purinergic signaling and immune modulation at the schistosome surface? Trends Parasitol 2009; 25:256-60.
    • (2009) Trends Parasitol , vol.25 , pp. 256-260
    • Bhardwaj, R.1    Skelly, P.J.2
  • 120
    • 0031205443 scopus 로고    scopus 로고
    • Selective loss of the calcium ion signaling pathway in T cells maturing toward a T helper 2 phenotype
    • Sloan-Lancaster J, Steinberg TH, Allen PM. Selective loss of the calcium ion signaling pathway in T cells maturing toward a T helper 2 phenotype. J Immunol 1997; 159:1160-8.
    • (1997) J Immunol , vol.159 , pp. 1160-1168
    • Sloan-Lancaster, J.1    Steinberg, T.H.2    Allen, P.M.3
  • 121
    • 0025288654 scopus 로고
    • Evidence implicating utilization of different T cell receptor-associated signaling pathways by TH1 and TH2 clones
    • Gajewski TF, Schell SR, Fitch FW. Evidence implicating utilization of different T cell receptor-associated signaling pathways by TH1 and TH2 clones. J Immunol 1990; 144:4110-20.
    • (1990) J Immunol , vol.144 , pp. 4110-4120
    • Gajewski, T.F.1    Schell, S.R.2    Fitch, F.W.3
  • 123
    • 62749120029 scopus 로고    scopus 로고
    • Signals for the execution of Th2 effector function
    • Fowell DJ. Signals for the execution of Th2 effector function. Cytokine 2009; 46:1-6.
    • (2009) Cytokine , vol.46 , pp. 1-6
    • Fowell, D.J.1
  • 124
  • 125
    • 77952585347 scopus 로고    scopus 로고
    • Sustained signaling by canonical helper T cell cytokines throughout the reactive lymph node
    • Perona-Wright G, Mohrs K, Mohrs M. Sustained signaling by canonical helper T cell cytokines throughout the reactive lymph node. Nat Immunol 2010; 11:520-6.
    • (2010) Nat Immunol , vol.11 , pp. 520-526
    • Perona-Wright, G.1    Mohrs, K.2    Mohrs, M.3
  • 126
    • 0035555263 scopus 로고    scopus 로고
    • Deletion of a coordinate regulator of type 2 cytokine expression in mice
    • Mohrs M, Blankespoor CM, Wang ZE et al. Deletion of a coordinate regulator of type 2 cytokine expression in mice. Nat Immunol 2001; 2:842-7.
    • (2001) Nat Immunol , vol.2 , pp. 842-847
    • Mohrs, M.1    Blankespoor, C.M.2    Wang, Z.E.3
  • 127
    • 0035984591 scopus 로고    scopus 로고
    • A 3' enhancer in the IL-4 gene regulates cytokine production by Th2 cells and mast cells
    • Solymar DC, Agarwal S, Bassing CH, Alt FW, Rao A. A 3' enhancer in the IL-4 gene regulates cytokine production by Th2 cells and mast cells. Immunity 2002; 17:41-50.
    • (2002) Immunity , vol.17 , pp. 41-50
    • Solymar, D.C.1    Agarwal, S.2    Bassing, C.H.3    Alt, F.W.4    Rao, A.5
  • 128
    • 23344453342 scopus 로고    scopus 로고
    • A critical control element for interleukin-4 memory expression in T helper lymphocytes
    • Tykocinski LO, Hajkova P, Chang HD et al. A critical control element for interleukin-4 memory expression in T helper lymphocytes. J Biol Chem 2005; 280:28177-85.
    • (2005) J Biol Chem , vol.280 , pp. 28177-28185
    • Tykocinski, L.O.1    Hajkova, P.2    Chang, H.D.3
  • 129
    • 26644448473 scopus 로고    scopus 로고
    • A two-step process for cytokine production revealed by IL-4 dual-reporter mice
    • Mohrs K, Wakil AE, Killeen N, Locksley RM, Mohrs M. A two-step process for cytokine production revealed by IL-4 dual-reporter mice. Immunity 2005; 23:419-29.
    • (2005) Immunity , vol.23 , pp. 419-429
    • Mohrs, K.1    Wakil, A.E.2    Killeen, N.3    Locksley, R.M.4    Mohrs, M.5
  • 130
    • 75749149721 scopus 로고    scopus 로고
    • Thymic stromal lymphopoietin
    • He R, Geha RS. Thymic stromal lymphopoietin. Ann N Y Acad Sci 2010; 1183:13-24.
    • (2010) Ann N Y Acad Sci , vol.1183 , pp. 13-24
    • He, R.1    Geha, R.S.2
  • 132
    • 2442717844 scopus 로고    scopus 로고
    • Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology
    • Herbert DR, Holscher C, Mohrs M et al. Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology. Immunity 2004; 20:623-35.
    • (2004) Immunity , vol.20 , pp. 623-635
    • Herbert, D.R.1    Holscher, C.2    Mohrs, M.3
  • 134
    • 0018837746 scopus 로고
    • Antigen-induced T cell-replacing factor (TRF). I. Functional characterization of a TRF-producing helper T cell subset and genetic studies on TRF production
    • Takatsu K, Tominaga A, Hamaoka T. Antigen-induced T cell-replacing factor (TRF). I. Functional characterization of a TRF-producing helper T cell subset and genetic studies on TRF production. J Immunol 1980; 124:2414-22.
    • (1980) J Immunol , vol.124 , pp. 2414-2422
    • Takatsu, K.1    Tominaga, A.2    Hamaoka, T.3
  • 135
    • 0037775352 scopus 로고    scopus 로고
    • IL-13 effector functions
    • Wynn TA. IL-13 effector functions. Annu Rev Immunol 2003; 21:425-56.
    • (2003) Annu Rev Immunol , vol.21 , pp. 425-456
    • Wynn, T.A.1
  • 137
    • 69249150516 scopus 로고    scopus 로고
    • T-helper type 2-driven inflammation defines major subphenotypes of asthma
    • Woodruff PG, Modrek B, Choy DF et al. T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am J Respir Crit Care Med 2009; 180:388-95.
    • (2009) Am J Respir Crit Care Med , vol.180 , pp. 388-395
    • Woodruff, P.G.1    Modrek, B.2    Choy, D.F.3
  • 138
    • 77949503208 scopus 로고    scopus 로고
    • Narrative review: the role of Th2 immune pathway modulation in the treatment of severe asthma and its phenotypes
    • Levine SJ, Wenzel SE. Narrative review: the role of Th2 immune pathway modulation in the treatment of severe asthma and its phenotypes. Ann Intern Med 2010; 152:232-7.
    • (2010) Ann Intern Med , vol.152 , pp. 232-237
    • Levine, S.J.1    Wenzel, S.E.2
  • 139
    • 0035749672 scopus 로고    scopus 로고
    • Cytokine modulators for allergic diseases
    • Barnes PJ. Cytokine modulators for allergic diseases. Curr Opin Allergy Clin Immunol 2001; 1:555-60.
    • (2001) Curr Opin Allergy Clin Immunol , vol.1 , pp. 555-560
    • Barnes, P.J.1
  • 140
    • 35348909044 scopus 로고    scopus 로고
    • Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies
    • Wenzel S, Wilbraham D, Fuller R, Getz EB, Longphre M. Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies. Lancet 2007; 370:1422-31.
    • (2007) Lancet , vol.370 , pp. 1422-1431
    • Wenzel, S.1    Wilbraham, D.2    Fuller, R.3    Getz, E.B.4    Longphre, M.5


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