The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1)

Journal of Experimental Medicine

Volumn 206, Issue 8, 2009, Pages 1681-1690

  Steinfelder, Svenja ^a,c   Andersen, John F ^a   Cannons, Jennifer L ^b   Feng, Carl G ^a   Joshi, Manju ^a   Dwyer, Dennis ^a   Caspar, Pat ^a   Schwartzberg, Pamela L ^b   Sher, Alan ^a   Jankovic, Dragana ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MYELOID DIFFERENTIATION FACTOR 88; PROTEIN OMEGA 1; RIBONUCLEASE; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DENDRITIC CELL; ENZYME ANALYSIS; FEMALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SCHISTOSOMA MANSONI; SIGNAL TRANSDUCTION; TH2 CELL;

ANIMALS; ANTIGENS, HELMINTH; CELL ADHESION; CELL DIFFERENTIATION; CULTURE MEDIA, CONDITIONED; DENDRITIC CELLS; FEMALE; HELMINTH PROTEINS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; OVUM; RIBONUCLEASES; SCHISTOSOMA MANSONI; TH2 CELLS;

EID: 68149163162     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20082462     Document Type: Article

References (35)

1. Abbas, A.K., K.M. Murphy, and A. Sher. 1996. Functional diversity of helper T lymphocytes. Nature. 383:787-793.
2. Aksoy, E., C.S. Zouain, F. Vanhoutte, J. Fontaine, N. Pavelka, N. Thieblemont, F. Willems, P. Ricciardi-Castagnoli, M. Goldman, M. Capron, et al. 2005. Double-stranded RNAs from the helminth parasite Schistosoma activate TLR3 in dendritic cells. J. Biol. Chem. 280:277-283.
3. Al-Alwan, M.M., R.S. Liwski, S.M. Haeryfar, W.H. Baldridge, D.W. Hoskin, G. Rowden, and K.A. West. 2003. Cutting edge: dendritic cell actin cytoskeletal polarization during immunological synapse formation is highly antigen-dependent. J. Immunol. 171:4479-4483.
4. Arruda, L.K., T.A. Platts-Mills, J.W. Fox, and M.D. Chapman. 1990. Aspergillus fumigatus allergen I, a major IgE-binding protein, is a member of the mitogillin family of cytotoxins. J. Exp. Med. 172:1529-1532.
5. Ashton, P.D., R. Harrop, B. Shah, and R.A. Wilson. 2001. The schistosome egg: development and secretions. Parasitology. 122:329-338.
6. Bufe, A., G. Schramm, M.B. Keown, M. Schlaak, and W.M. Becker. 1995. Major allergen Phl p Vb in timothy grass is a novel pollen RNase. FEBS Lett. 363:6-12.
7. Bufe, A., M.D. Spangfort, H. Kahlert, M. Schlaak, and W.M. Becker. 1996. The major birch pollen allergen, Bet v 1, shows ribonuclease activity. Planta. 199:413-415.
8. + T cells. J. Exp. Med. 182:1591-1596.
9. de Jong, E.C., P.L. Vieira, P. Kalinski, J.H. Schuitemaker, Y. Tanaka, E.A. Wierenga, M. Yazdanbakhsh, and M.L. Kapsenberg. 2002. Microbial compounds selectively induce Th1 cell-promoting or Th2 cell-promoting dendritic cells in vitro with diverse Th cell-polarizing signals. J. Immunol. 168:1704-1709.
10. Donnelly, S., J.P. Dalton, and A. Loukas. 2006. Proteases in helminth- and allergen-induced inflammatory responses. Chem. Immunol. Allergy. 90:45-64.
11. Donnelly, S., C.M. Stack, S.M. O'Neill, A.A. Sayed, D.L. Williams, and J.P. Dalton. 2008. Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages. FASEB J. 22:4022-4032.
12. Everts, B., G. Perona-Wright, H.H. Smits, C.H. Hokke, A.J. van der Ham, C.M. Fitzsimmons, M.J. Doenhoff, J. van der Bosch, K. Mohrs, H. Haas, et al. 2009. Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses. J. Exp. Med. 206:1673-1680.
13. Faveeuw, C., K. Mallevaey, K. Paschinger, I.B. Wilson, J. Fontaine, R. Mollicone, R. Oriol, F. Altmann, P. Lerouge, M. Capron, and F. Trottein. 2003. Schistosome N-glycans containing core α3-fucose and core β2-xylose epitopes are strong inducers of Th2 responses in mice. Eur. J. Immunol. 33:1271-1281.
14. Fitzsimmons, C.M., G. Schramm, F.M. Jones, I.W. Chalmers, K.F. Hoffmann, C.G. Grevelding, M. Wuhrer, C.H. Hokke, H. Haas, M.J. Doenhoff, and D.W. Dunne. 2005. Molecular characterization of omega-1: a hepatotoxic ribonuclease from Schistosoma mansoni eggs. Mol. Biochem. Parasitol. 144:123-127.
15. + T helper cell phenotype development in a T cell receptor-αβ-transgenic model. J. Exp. Med. 182:1579-1584.
16. Jankovic, D., M.C. Kullberg, D. Dombrowicz, S. Barbieri, P. Caspar, T.W. Wynn, W.E. Paul, A.W. Cheever, J.P. Kinet, and A. Sher. 1997. FcεRI-deficient mice infected with Schistosoma mansoni mount normal Th2-type responses while displaying enhanced liver pathology. J. Immunol. 159:1868-1875.
17. -/- setting. Immunity. 16:429-439.
18. Jankovic, D., M.C. Kullberg, P. Caspar, and A. Sher. 2004. Parasite-induced Th2 polarization is associated with down-regulated dendritic cell responsiveness to Th1 stimuli and a transient delay in T lymphocyte cycling. J. Immunol. 173:2419-2427.
19. Joshi, M.B., and D.M. Dwyer. 2007. Molecular and functional analyses of a novel class I secretory nuclease from the human pathogen, Leishmania donovani. J. Biol. Chem. 282:10079-10095.
20. Kane, C.M., L. Cervi, J. Sun, A.S. McKee, K.S. Masek, S. Shapira, C.A. Hunter, and E.J. Pearce. 2004. Helfminth antigens modulate TLR-initiated dendritic cell activation. J. Immunol. 173:7454-7461.
21. - dendritic cell activation status plays an integral role in influencing Th2 response development. J. Immunol. 167:1982-1988.
22. MacDonald, A.S., A.D. Straw, N.M. Dalton, and E.J. Pearce. 2002. Cutting edge: Th2 response induction by dendritic cells: a role for CD40. J. Immunol. 168:537-540.
23. Medzhitov, R. 2007. Recognition of microorganisms and activation of the immune response. Nature. 449:819-826.
24. Ouyang, W., J.K. Kolls, and Y. Zheng. 2008. The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity. 28:454-467.
25. Pearce, E.J., C.M. Kane, J. Sun, J.J. Taylor, A.S. McKee, and L. Cervi. 2004. Th2 response polarization during infection with the helminth parasite Schistosoma mansoni. Immunol. Rev. 201:117-126.
26. Perona-Wright, G., S.J. Jenkins, and A.S. MacDonald. 2006. Dendritic cell activation and function in response to Schistosoma mansoni. Int. J. Parasitol. 36:711-721.
27. Qi, H., J.L. Cannons, F. Klauschen, P.L. Schwartzberg, and R.N. Germain. 2008. SAP-controlled T-B cell interactions underlie germinal center formation. Nature. 455:764-769.
28. Roiz, L., P. Smirnoff, M. Bar-Eli, B. Schwartz, and O. Shoseyov. 2006. ACTIBIND, an actin-binding fungal T2-RNase with antiangiogenic and anticarcinogenic characteristics. Cancer. 106:2295-2308.
29. Schramm, G., F.H. Falcone, A. Gronow, K. Haisch, U. Mamat, M.J. Doenhoff, G. Oliveira, J. Galle, C.A. Dahinden, and H. Haas. 2003. Molecular characterization of an Interleukin-4-inducing factor from Schistosoma mansoni eggs. J. Biol. Chem. 278:18384-18392.
30. Sokol, C.L., G.M. Barton, A.G. Farr, and R. Medzhitov. 2008. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nat. Immunol. 9:310-318.
31. Thomas, P.G., M.R. Carter, O. Atochina, A.A. Da'Dara, D. Piskorska, E. McGuire, and D.A. Harn. 2003. Maturation of dendritic cell 2 phenotype by a helminth glycan uses a Toll-like receptor 4-dependent mechanism. J. Immunol. 171:5837-5841.
32. van der Kleij, D., E. Latz, J.F. Brouwers, Y.C. Kruize, M. Schmitz, E.A. Kurt-Jones, T. Espevik, E.C. de Jong, M.L. Kapsenberg, D.T. Golenbock, et al. 2002. A novel host-parasite lipid cross-talk. Schistosomal lysophosphatidylserine activates toll-like receptor 2 and affects immune polarization. J. Biol. Chem. 277:48122-48129.
33. Yamamoto, M., S. Sato, H. Hemmi, K. Hoshino, T. Kaisho, H. Sanjo, O. Takeuchi, M. Sugiyama, M. Okabe, K. Takeda, and S. Akira. 2003. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science. 301:640-643.
34. Yang, D., Q. Chen, S.B. Su, P. Zhang, K. Kurosaka, R.R. Caspi, S.M. Michalek, H.F. Rosenberg, N. Zhang, and J.J. Oppenheim. 2008. Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses. J. Exp. Med. 205:79-90.
35. Zhu, J., and W.E. Paul. 2008. CD4 T cells: fates, functions, and faults. Blood. 112:1557-1569.