Toll-like receptors and dendritic cells: For whom the bug tolls

Seminars in Immunology

Volumn 16, Issue 1, 2004, Pages 27-34

  Reis E Sousa, Caetano ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

Co stimulation; Cytokines; Dendritic cells; Innate recognition; Toll like receptors

Indexed keywords

CYTOKINE; LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN; OLIGODEOXYNUCLEOTIDE DERIVATIVE; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 10; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG;

ANTIGEN RECOGNITION; CELL DIFFERENTIATION; CELL FUNCTION; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; EFFECTOR CELL; HUMAN; IMMUNITY; IMMUNOMODULATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR RECOGNITION; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

EID: 0742272509     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.smim.2003.10.004     Document Type: Article

References (82)

1. Janeway C.A. Jr. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb. Symp. Quant. Biol. 54:1989;1-13.
2. Banchereau J., Briere F., Caux C., Davoust J., Lebecque S., Liu Y.J.et al. Immunobiology of dendritic cells. Annu. Rev. Immunol. 18:2000;767-811.
3. Akira S. Mammalian toll-like receptors. Curr. Opin. Immunol. 15:2003;5-11.
4. Kalinski P., Hilkens C.M., Wierenga E.A., Kapsenberg M.L. T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal. Immunol. Today. 20:1999;561-567.
5. Cella M., Engering A., Pinet V., Pieters J., Lanzavecchia A. Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells. Nature. 388:1997;782-787.
6. Inaba K., Turley S., Iyoda T., Yamaide F., Shimoyama S., Reis e Sousa C.et al. The formation of immunogenic major histocompatibility complex class II- peptide ligands in lysosomal compartments of dendritic cells is regulated by inflammatory stimuli. J. Exp. Med. 191:2000;927-936.
7. Manickasingham S., Reis e Sousa C. Microbial and T cell-derived stimuli regulate antigen presentation by dendritic cells in vivo. J. Immunol. 165:2000;5027-5034.
8. Delamarre L., Holcombe H., Meilman I. Presentation of exogenous antigens on Major Histocompatibility Complex (MHC) class I and MHC class II molecules is differentially regulated during dendritic cell maturation. J. Exp. Med. 198:2003;111-122.
9. Datta S.K., Redecke V., Prilliman K.R., Takabayashi K., Corr M., Tallant T.et al. A subset of Toll-like receptor ligands induces cross-presentation by bone marrow-derived dendritic cells. J. Immunol. 170:2003;4102-4110.
10. Hoshino K., Kaisho T., Iwabe T., Takeuchi O., Akira S. Differential involvement of IFN-beta in Toll-like receptor-stimulated dendritic cell activation. Int. Immunol. 14:2002;1225-1231.
11. Gallucci S., Lolkema M., Matzinger P. Natural adjuvants: endogenous activators of dendritic cells. Nat. Med. 5:1999;1249-1255.
12. Le Bon A., Schiavoni G., D'Agostino G., Gresser I., Belardelli F., Tough D.F. Type i interferons potently enhance humoral immunity and can promote isotype switching by stimulating dendritic cells in vivo. Immunity. 14:2001;461-470.
13. Mattei F., Schiavoni G., Belardelli F., Tough D.F. IL-15 is expressed by dendritic cells in response to type I IFN, double-stranded RNA, or lipopolysaccharide and promotes dendritic cell activation. J. Immunol. 167:2001;1179-1187.
14. Lebre M.C., Antons J.C., Kalinski P., Schuitemaker J.H., van Capel T.M., Kapsenberg M.L.et al. Double-stranded RNA-exposed human keratinocytes promote Th1 responses by inducing a Type-1 polarized phenotype in dendritic cells: role of keratinocyte-derived tumor necrosis factor alpha, type I interferons, and interleukin-18. J. Invest. Dermatol. 120:2003;990-997.
15. Pasare C., Medzhitov R. Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science. 299:2003;1033-1036.
16. Mitchell T.C., Hildeman D., Kedl R.M., Teague T.K., Schaefer B.C., White J.et al. Immunological adjuvants promote activated T cell survival via induction of Bcl-3. Nat. Immunol. 2:2001;397-402.
17. Granucci F., Feau S., Angeli V., Trottein F., Ricciardi-Castagnoli P. Early IL-2 production by mouse dendritic cells is the result of microbial-induced priming. J. Immunol. 170:2003;5075-5081.
18. Krieg A.M. CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol. 20:2002;709-760.
19. Pulendran B., Kumar P., Cutler C.W., Mohamadzadeh M., Van Dyke T., Banchereau J. Lipopolysaccharides from distinct pathogens induce different classes of immune responses in vivo. J. Immunol. 167:2001;5067-5076.
20. Re F., Strominger J.L. Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells. J. Biol. Chem. 276:2001;37692-37699.
21. Edwards A.D., Manickasingham S.P., Spörri R., Diebold S.S., Schulz O., Sher A.et al. Microbial recognition via toll-like receptor-dependent and -independent pathways determines the cytokine response of murine dendritic cell subsets to CD40 triggering. J. Immunol. 169:2002;3652-3660.
22. Kadowaki N., Ho S., Antonenko S., de Waal Malefyt R., Kastelein R.A., Bazan F.et al. Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J. Exp. Med. 194:2001;863-870.
23. Hemmi H., Kaisho T., Takeda K., Akira S. The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets. J. Immunol. 170:2003;3059-3064.
24. Marshall J.D., Fearon K., Abbate C., Subramanian S., Yee P., Gregorio J.et al. Identification of a novel CpG DNA class and motif that optimally stimulate B cell and plasmacytoid dendritic cell functions. J. Leukoc. Biol. 73:2003;781-792.
25. Alexopoulou L., Holt A.C., Medzhitov R., Flavell R.A. Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3. Nature. 413:2001;732-738.
26. Underhill D.M., Ozinsky A., Hajjar A.M., Stevens A., Wilson C.B., Bassetti M.et al. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature. 401:1999;811-815.
27. Gantner B.N., Simmons R.M., Canavera S.J., Akira S., Underhill D.M. Collaborative Induction of Inflammatory Responses by Dectin-1 and Toll-like Receptor 2. J. Exp. Med. 197:2003;1107-1117.
28. Hemmi H., Kaisho T., Takeuchi O., Sato S., Sanjo H., Hoshino K.et al. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat. Immunol. 3:2002;196-200.
29. Jurk M., Heil F., Vollmer J., Schetter C., Krieg A.M., Wagner H.et al. Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848. Nat. Immunol. 3:2002;499.
30. Lee J., Chuang T.H., Redecke V., She L., Pitha P.M., Carson D.A.et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc. Natl. Acad. Sci. U.S.A. 100:2003;6646-6651.
31. Shortman K., Liu Y. Mouse and human dendritic cell subtypes. Nat. Rev. Immunol. 2:2002;151-161.
32. Muzio M., Bosisio D., Polentarutti N., D'Amico O., Stoppacciaro A., Mancinelli R.et al. Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells. J. Immunol. 164:2000;5998-6004.
33. Visintin A., Mazzoni A., Spitzer J.H., Wyllie D.H., Dower S.K., Segal D.M. Regulation of ToH-like receptors in human monocytes and dendritic cells. J. Immunol. 166:2001;249-255.
34. Means T.K., Hayashi F., Smith K.D., Aderem A., Luster A.D. The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells. J. Immunol. 170:2003;5165-5175.
35. Krug A., Towarowski A., Britsch S., Rothenfusser S., Homung V., Bals R. et al. Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12. Eur. J. Immunol. 31:2001;3026-3037.
36. Jarrossay D., Napolitani G., Colonna M., Sallusto F., Lanzavecchia A. Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells. Eur. J. Immunol. 31:2001;3388-3393.
37. Kadowaki N., Antonenko S., Liu Y.J. Distinct CpG DNA and polyinosinic-polycytidylic acid double-stranded RNA, respectively, stimulate CD11c- type 2 dendritic cell precursors and CD11c+ dendritic cells to produce type I IFN. J. Immunol. 166:2001;2291-2295.
38. Homung V., Rothenfusser S., Britsch S., Krug A., Jahrsdorfer B., Giese T.et al. Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J. Immunol. 168:2002;4531-4537.
39. Schattenberg D., Schott M., Reindi G., Krueger T., Tschoepe D., Feldkamp J.et al. Response of human monocyte-derived dendritic cells to immunostimulatory DNA. Eur. J. Immunol. 30:2000;2824-2831.
40. Ito T., Amakawa R., Kaisho T., Hemmi H., Tajima K., Uehira K.et al. Interferon-alpha and interleukin-12 are induced differentially by Toll- like receptor 7 ligands in human blood dendritic cell subsets. J. Exp. Med. 195:2002;1507-1512.
41. + DC correlates with unresponsiveness to imidazoquinolines. Eur J. Immunol. 33:2003;827-833.
42. Brawand P., Fitzpatrick D.R., Greenfield B.W., Brasel K., Maliszewski C.R., De Smedt T. Murine plasmacytoid pre-dendritic cells generated from Flt3 ligand-supplemented bone marrow cultures are immature APCs. J. Immunol. 169:2002;6711-6719.
43. Boonstra A., Asselin-Paturel C., Gilliet M., Cram C., Trinchieri G., Liu Y.J.et al. Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential toll-like receptor ligation. J. Exp. Med. 197:2003;101-109.
44. Okada T., Lian Z.X., Naiki M., Ansari A.A., Ikehara S., Gershwin M.E. Murine thymic plasmacytoid dendritic cells. Eur. J. Immunol. 33:2003;1012-1019.
45. Doxsee C.L., Riter T.R., Reiter M.J., Gibson S.J., Vasilakos J.P., Kedl R.M. The immune response modifier and toll-like receptor 7 agonist S-27609 selectively induces IL-12 and TNF-alpha production in CD11c(+)CD11b(+)CD8(-) dendritic cells. J. Immunol. 171:2003;1156-1163.
46. Triantafilou M., Triantafilou K. Lipopolysaccharide recognition: CD 14, TLRs and the LPS-activation cluster. Trends Immunol. 23:2002;301-304.
47. Rissoan M.C., Soumelis V., Kadowaki N., Grouard G., Briere F., de Waal Malefyt R.et al. Reciprocal control of T helper cell and dendritic cell differentiation. Science. 283:1999;1183-1186.
48. Pulendran B., Smith J.L., Caspary G., Brasel K., Pettit D., Maraskovsky E.et al. Distinct dendritic cell subsets differentially regulate the class of immune response in vivo. Proc. Natl. Acad. Sci. U.S.A. 96:1999;1036-1041.
49. Maldonado-Lopez R., De Smedt T., Pajak B., Heirman C., Thielemans K., Leo O.et al. Role of CD8alpha+ and CD8alpha- dendritic cells in the induction of primary immune responses in vivo. J. Leukoc. Biol. 66:1999;242-246.
50. HI polarization. Nat. Immunol. 1:2000;305-310.
51. Kadowaki N., Antonenko S., Lau J.Y., Liu Y.J. Natural interferon alpha/beta-producing cells link innate and adaptive immunity. J. Exp. Med. 192:2000;219-226.
52. Manickasingham S.P., Edwards A.D., Schulz O., Reis e Sousa C. The ability of murine dendritic cell subsets to direct Th differentiation is dependent on microbial signals. Eur. J. Immunol. 33:2003;101-107.
53. Krug A., Rothenfusser S., Homung V., Jahrsdorfer B., Blackwell S., Ballas Z.K.et al. Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells. Eur. J. Immunol. 31:2001;2154-2163.
54. Stunz L.L., Lenert P., Peckham D., Yi A.K., Haxhinasto S., Chang M.et al. Inhibitory oligonucleotides specifically block effects of stimulatory CpG oligonucleotides in B cells. Eur. J. Immunol. 32:2002;1212-1222.
55. Lund J., Sato A., Akira S., Medzhitov R., Iwasaki A. Toll-like receptor 9-mediated recognition of herpes simplex virus-2 by plasmacytoid dendritic cells. J. Exp. Med. 198:2003;1-9.
56. Jacobs B.L., Langland J.O. When two strands are better than one: the mediators and modulators of the cellular responses to double-stranded RNA. Virology. 219:1996;339-349.
57. Diebold S.S., Montoya M., Unger H., Alexopoulou L., Roy P., Haswell L.et al. Viral infection switches non-plasmacytoid dendritic cells into high interferon producers. Nature. 424:2003;324-328.
58. Edwards A.D., Diebold S.S., Slack E.M., Tomizawa H., Hemmi H., Kaisho T.et al. Toll-like receptor expression in murine DC subsets: lack of TLR7 expression by CD8 alpha+ DC correlates with unresponsiveness to imidazoquinolines. Eur. J. Immunol. 33:2003;827-833.
59. Iyoda T., Shimoyama S., Liu K., Omatsu Y., Akiyama Y., Maeda Y.et al. The CD8(+) dendritic cell subset selectively endocytoses dying cells in culture and in vivo. J. Exp. Med. 195:2002;1289-1302.
60. + dendritic cells is attributable to their ability to internalise dead cells. Immunology. 107:2002;183-189.
61. Matzinger P. Tolerance, danger, and the extended family. Annu. Rev. Immunol. 12:1994;991-1045.
62. Beg A.A. Endogenous ligands of Toll-like receptors: implications for regulating inflammatory and immune responses. Trends Immunol. 23:2002;509-512.
63. Leadbetter E.A., Rifkin I.R., Hohibaum A.M., Beaudette B.C., Shlomchik M.J., Marshak-Rothstein A. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature. 416:2002;603-607.
64. Ishii K.J., Suzuki K., Coban C., Takeshita F., Itoh Y., Matoba H.et al. Genomic DNA released by dying cells induces the maturation of APCs. J. Immunol. 167:2001;2602-2607.
65. Goldstein D.R., Tesar B.M., Akira S., Lakkis F.G. Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection. J. Clin Invest. 111:2003;1571-1578.
66. Rassa J.C., Meyers J.L., Zhang Y., Kudaravalli R., Ross S.R. Murine retroviruses activate B cells via interaction with toll-like receptor 4. Proc. Natl. Acad. Sci. U.S.A. 99:2002;2281-2286.
67. Jude B.A., Pobezinskaya Y., Bishop J., Parke S., Medzhitov R.M., Chervonsky A.V.et al. Subversion of the innate immune system by a retrovirus. Nat. Immunol. 4:2003;573-578.
68. Kaisho T., Takeuchi O., Kawai T., Hoshino K., Akira S. Endotoxin-induced maturation of MyD88-deficient dendritic cells. J. Immunol. 166:2001;5688-5694.
69. Horng T., Barton G.M., Medzhitov R. TIRAP: an adapter molecule in the Toll signaling pathway. Nat. Immunol. 2:2001;835-841.
70. Kawai T., Takeuchi O., Fujita T., Inoue Ji J., Muhlradt P.F., Sato S.et al. Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J. Immunol. 167:2001;5887-5894.
71. Doyle S., Vaidya S., O'Connell R., Dadgostar H., Dempsey P., Wu T.et al. IRF3 mediates a TLR3/TLR4-specific antiviral gene program. Immunity. 17:2002;251-263.
72. Toshchakov V., Jones B.W., Perera P.Y., Thomas K., Cody M.J., Zhang S.et al. TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages. Nat. Immunol. 3:2002;392-398.
73. Yamamoto M., Sato S., Hemmi H., Hoshino K., Kaisho T., Sanjo H.et al. Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science. 301:2003;640-643.
74. Sato M., Suemori H., Hata N., Asagiri M., Ogasawara K., Nakao K.et al. Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction. Immunity. 13:2000;539-548.
75. Ogata H., Su I., Miyake K., Nagai Y., Akashi S., Mecklenbrauker I.et al. The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells. J. Exp. Med. 192:2000;23-29.
76. Scanga C.A., Aliberti J., Jankovic D., Tilloy F., Bennouna S., Denkers E.Y.et al. Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells. J. Immunol. 168:2002;5997-6001.
77. + dendritic cells. Nat. Immunol. 1:2000;83-87.
78. Aliberti J., Valenzuela J.G., Carruthers V.B., Hieny S., Andersen J., Charest H.et al. Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells. Nat. Immunol. 4:2003;485-490.
79. Triantafilou K., Triantafilou M., Dedrick R.L. A CD14-independent LPS receptor cluster. Nat. Immunol. 2:2001;338-345.
80. Underhill D.M. Mini-review Toll-like receptors: networking for success. Eur. J. Immunol. 33:2003;1767-1775.
81. Donne J. Meditation XVII: "No man is an island". In: Raspa AN, editor. Devotions upon emergent occasions. Oxford: Oxford University Press; 1624.
82. Liu T., Matsuguchi T., Tsuboi N., Yajima T., Yoshikai Y. Differences in expression of toll-like receptors and their reactivities in dendritic cells in BALB/c and C57BL/6 mice. Infect. Immunol. 70:2002;6638-6645.