Amyotrophic lateral sclerosis is a non-amyloid disease in which extensive misfolding of SOD1 is unique to the familial form

Acta Neuropathologica

Volumn 119, Issue 3, 2010, Pages 335-344

  Kerman, Aaron ^a,b   Liu, Hsueh Ning ^c   Croul, Sidney ^a   Bilbao, Juan ^d   Rogaeva, Ekaterina ^c   Zinman, Lorne ^d   Robertson, Janice ^c   Chakrabartty, Avijit ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d SUNNYBROOK RESEARCH INSTITUTE   (Canada)

Author keywords

Amyloid; Amyotrophic lateral sclerosis; Conformation specific antibodies; Conformational disease; Cu Zn superoxide dismutase; Inclusion bodies; Protein misfolding

Indexed keywords

CONGO RED; COPPER ZINC SUPEROXIDE DISMUTASE; DIRECT YELLOW 7; TAR DNA BINDING PROTEIN; THIOFLAVINE; UBIQUITIN; UNCLASSIFIED DRUG;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL INCLUSION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IN VIVO STUDY; MOTONEURON; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FOLDING; SPINAL CORD;

AMYLOID; AMYOTROPHIC LATERAL SCLEROSIS; ANTIBODIES; ANTIBODY SPECIFICITY; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; INCLUSION BODIES; MODELS, MOLECULAR; NEURONS; PROTEIN CONFORMATION; PROTEOSTASIS DEFICIENCIES; SUPEROXIDE DISMUTASE; TDP-43 PROTEINOPATHIES; UBIQUITIN;

EID: 77953028624     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-010-0646-5     Document Type: Article

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