A "two-hit" hypothesis for inclusion formation by carboxyl-terminal fragments of TDP-43 protein linked to RNA depletion and impaired microtubule-dependent transport

Journal of Biological Chemistry

Volumn 286, Issue 21, 2011, Pages 18845-18855

  Pesiridis, G Scott ^a   Tripathy, Kalyan ^a   Tanik, Selçuk ^a   Trojanowski, John Q ^a   Lee, Virginia M Y ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYOTROPHIC LATERAL SCLEROSIS; BIOLOGICAL SIGNIFICANCE; CARBOXYL-TERMINAL; CLEAVAGE SITES; CYTOPLASMIC INCLUSION; DATA SUPPORT; INCLUSION FORMATION; MAMMALIAN CELLS; MICROTUBULES; RNA-RECOGNITION MOTIFS; TOBACCO ETCH VIRUS PROTEASE;

CYTOLOGY; INCLUSIONS; MAMMALS; VIRUSES;

RNA;

TAR DNA BINDING PROTEIN;

ANIMAL CELL; ARTICLE; CELL TRANSPORT; CONTROLLED STUDY; CYTOPLASM; MICROTUBULE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT;

ACTIVE TRANSPORT, CELL NUCLEUS; AMINO ACID MOTIFS; AMYOTROPHIC LATERAL SCLEROSIS; CELL LINE; CELL NUCLEUS; CYTOPLASM; DNA-BINDING PROTEINS; DYNEINS; FRONTOTEMPORAL LOBAR DEGENERATION; HUMANS; MICROTUBULES; RNA;

MAMMALIA; TOBACCO ETCH VIRUS;

EID: 79956304001     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.231118     Document Type: Article

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