Molecular determinants and genetic modifiers of aggregation and toxicity for the als disease protein fus/tls

PLoS Biology

Volumn 9, Issue 4, 2011, Pages

  Sun, Zhihui ^a   Diaz, Zamia ^a   Fang, Xiaodong ^a   Hart, Michael P ^a   Chesi, Alessandra ^a   Shorter, James ^a   Gitler, Aaron D ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OLIGOMER; PROTEIN FUS; PROTEIN TLS; RNA BINDING PROTEIN; TAR DNA BINDING PROTEIN; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; HYBRID PROTEIN; PROTEIN TDP-43;

AMINO TERMINAL SEQUENCE; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL GRANULE; CELL INCLUSION; CELL ORGANELLE; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; DNA MODIFICATION; GENE DELETION; GENE FUNCTION; GENETIC SCREENING; HUMAN; HUMAN CELL; NONHUMAN; P BODY; PROTEIN AGGREGATION; PROTEIN DOMAIN; PROTEIN ISOLATION; PROTEIN LOCALIZATION; PROTEIN PURIFICATION; PROTEIN RNA BINDING; PROTEIN STRUCTURE; STRESS GRANULE; YEAST CELL; BIOLOGY; CELL STRAIN HEK293; CHROMOSOME MAP; FRONTOTEMPORAL DEMENTIA; GENE EXPRESSION; GENETIC TRANSFECTION; GENETICS; METABOLISM; NERVE CELL; NUCLEOTIDE SEQUENCE; PATHOLOGY; SACCHAROMYCES CEREVISIAE;

AMYOTROPHIC LATERAL SCLEROSIS; BASE SEQUENCE; CHROMOSOME MAPPING; COMPUTATIONAL BIOLOGY; CYTOPLASM; DNA-BINDING PROTEINS; FRONTOTEMPORAL LOBAR DEGENERATION; GENE DELETION; GENE EXPRESSION; HEK293 CELLS; HUMANS; NEURONS; RECOMBINANT FUSION PROTEINS; RNA-BINDING PROTEIN FUS; SACCHAROMYCES CEREVISIAE; TRANSFECTION;

EID: 79955502687     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.1000614     Document Type: Article

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