Mammalian NADH: Ubiquinone oxidoreductase (Complex I) and nicotinamide nucleotide transhydrogenase (Nnt) together regulate the mitochondrial production of H 2O 2-Implications for their role in disease, especially cancer

Journal of Bioenergetics and Biomembranes

Volumn 43, Issue 5, 2011, Pages 541-564

  Albracht, Simon P J ^a   Meijer, Alfred J ^b   Rydström, Jan ^c  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Cancer; NADH:ubiquinone oxidoreductase; Reactive oxygen species (ROS); Transhydrogenase

Indexed keywords

GLUCOSE 6 PHOSPHATE; HEXOKINASE; HYDROGEN PEROXIDE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) TRANSHYDROGENASE; OXYGEN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); VON HIPPEL LINDAU PROTEIN;

APOPTOSIS; ARTICLE; AUTOPHAGY; BIOENERGY; CANCER CELL; CANCER SURVIVAL; ENERGY; ENZYME ACTIVE SITE; GLUCOSE METABOLISM; HEART MUSCLE CELL; MITOCHONDRIAL MEMBRANE; NEOPLASM; NONHUMAN; OXIDATIVE STRESS; PH; PHYSIOLOGY; SUBMITOCHONDRIAL PARTICLE; TUMOR VOLUME;

ANIMALS; ELECTRON TRANSPORT COMPLEX I; HUMANS; HYDROGEN PEROXIDE; MAMMALS; NADP TRANSHYDROGENASES; NEOPLASM PROTEINS; NEOPLASMS;

BOVINAE; MAMMALIA;

EID: 80054755736     PISSN: 0145479X     EISSN: 15736881     Source Type: Journal    
DOI: 10.1007/s10863-011-9381-4     Document Type: Article

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