Structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus

Science

Volumn 311, Issue 5766, 2006, Pages 1430-1436

  Sazanov, Leonid A ^a   Hinchliffe, Philip ^a  

^a WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANTS; BACTERIA; CELLS; CRYSTAL STRUCTURE; DISEASES; ELECTRON TRANSITIONS; ENZYMES; HYDROPHILICITY; IRON; REDOX REACTIONS; SULFUR;

AGING; CELLULAR ENERGY PRODUCTION; DYSFUNCTION; MITOCHONDRIA; NEURODEGENERATIVE DISEASES; RESPIRATORY COMPLEX I; THERMUS THERMOPHILUS;

RESPIRATORY SYSTEM;

ANTIOXIDANT; CHAPERONE; FLAVINE MONONUCLEOTIDE; FRATAXIN; IRON; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SULFUR;

RESPIRATION;

ARTICLE; CELL ENERGY; CRYSTAL STRUCTURE; ELECTRON TRANSPORT; ENZYME SUBUNIT; HYDROPHILICITY; MITOCHONDRION; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN FOLDING; STRUCTURE ANALYSIS; THERMUS THERMOPHILUS;

ANIMALS; BACTERIAL PROTEINS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ELECTRON TRANSPORT COMPLEX I; IRON-BINDING PROTEINS; OXIDATION-REDUCTION; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; THERMUS THERMOPHILUS;

NIA; THERMUS THERMOPHILUS;

EID: 33644872938     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1123809     Document Type: Article

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53. This work was funded by the Medical Research Council. We thank J. E. Walker, A. G. W. Leslie, and A. G. Murzin for helpful discussions of the manuscript; the European Synchrotron Radiation Facility for provision of synchrotron radiation facilities; and the staff of beamlines ID23 and ID29 for assistance. The coordinates and the structure factors have been deposited in the Protein Data Bank (accession code 2FUG).