Inhibitors of the quinone-binding site allow rapid superoxide production from mitochondrial NADH:ubiquinone oxidoreductase (complex I)

Journal of Biological Chemistry

Volumn 279, Issue 38, 2004, Pages 39414-39420

  Lambert, Adrian J ^a   Brand, Martin D ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; ELECTRON TRANSITIONS; HYDROGEN PEROXIDE; MUSCLE; OXIDES; PH EFFECTS;

ELECTRON TRANSPORT; INHIBITORS; SUPEROXIDE GENERATION;

ENZYME INHIBITION;

1,4 BENZOQUINONE; ADENOSINE TRIPHOSPHATE; HYDROGEN PEROXIDE; MYXOTHIAZOL; PYRUVIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); ROTENONE; STIGMATELLIN; SUCCINIC ACID; SUPEROXIDE;

ANIMAL TISSUE; ARTICLE; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTRON TRANSPORT; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; NONHUMAN; PH; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE;

ANIMALS; BENZOQUINONES; BINDING SITES; ELECTRON TRANSPORT; ELECTRON TRANSPORT COMPLEX I; FEMALE; HYDROGEN PEROXIDE; HYDROGEN-ION CONCENTRATION; MALATES; MITOCHONDRIA; PYRUVIC ACID; RATS; RATS, WISTAR; SUPEROXIDES;

ANIMALIA;

EID: 4544354262     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M406576200     Document Type: Article

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