메뉴 건너뛰기




Volumn 21, Issue 6, 2011, Pages 619-632

Unraveling the glioma epigenome-from molecular mechanisms to novel biomarkers and therapeutic targets

Author keywords

DNA methylation; glioma; histone modification; IDH1; MGMT

Indexed keywords

2 HYDROXYGLUTARIC ACID; 2 OXOGLUTARIC ACID; 5 METHYLCYTOSINE; BIOLOGICAL MARKER; HISTONE DEMETHYLASE; ISOCITRATE DEHYDROGENASE;

EID: 80054708001     PISSN: 10156305     EISSN: 17503639     Source Type: Journal    
DOI: 10.1111/j.1750-3639.2011.00536.x     Document Type: Review
Times cited : (28)

References (154)
  • 1
    • 20144387913 scopus 로고    scopus 로고
    • EMP3, a myelin-related gene located in the critical 19q13.3 region, is epigenetically silenced and exhibits features of a candidate tumor suppressor in glioma and neuroblastoma
    • DOI 10.1158/0008-5472.CAN-04-4283
    • Alaminos M, Dávalos V, Ropero S, Setién F, Paz MF, Herranz M, et al, (2005) EMP3, a myelin-related gene located in the critical 19q13.3 region, is epigenetically silenced and exhibits features of a candidate tumor suppressor in glioma and neuroblastoma. Cancer Res 65: 2565-2571. (Pubitemid 40490052)
    • (2005) Cancer Research , vol.65 , Issue.7 , pp. 2565-2571
    • Alaminos, M.1    Davalos, V.2    Ropero, S.3    Setien, F.4    Paz, M.F.5    Herranz, M.6    Fraga, M.F.7    Mora, J.8    Cheung, N.-K.V.9    Gerald, W.L.10    Esteller, M.11
  • 3
    • 79955811415 scopus 로고    scopus 로고
    • Nucleosome structure(s) and stability: Variations on a theme
    • Andrews AJ, Luger K, (2011) Nucleosome structure(s) and stability: variations on a theme. Annu Rev Biophys 40: 99-117.
    • (2011) Annu Rev Biophys , vol.40 , pp. 99-117
    • Andrews, A.J.1    Luger, K.2
  • 4
    • 52049098967 scopus 로고    scopus 로고
    • A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice
    • Aravin AA, Sachidanandam R, Bourc'his D, Schaefer C, Pezic D, Toth KF, et al, (2008) A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice. Mol Cell 31: 785-799.
    • (2008) Mol Cell , vol.31 , pp. 785-799
    • Aravin, A.A.1    Sachidanandam, R.2    Bourc'His, D.3    Schaefer, C.4    Pezic, D.5    Toth, K.F.6
  • 5
    • 79951969175 scopus 로고    scopus 로고
    • Histone chaperones: Modulators of chromatin marks
    • Avvakumov N, Nourani A, Côté J, (2011) Histone chaperones: modulators of chromatin marks. Mol Cell 41: 502-514.
    • (2011) Mol Cell , vol.41 , pp. 502-514
    • Avvakumov, N.1    Nourani, A.2    Côté, J.3
  • 6
    • 0142061145 scopus 로고    scopus 로고
    • PTEN methylation and expression in glioblastomas
    • DOI 10.1007/s00401-003-0748-4
    • Baeza N, Weller M, Yonekawa Y, Kleihues P, Ohgaki H, (2003) PTEN methylation and expression in glioblastomas. Acta Neuropathol 106: 479-485. (Pubitemid 37265852)
    • (2003) Acta Neuropathologica , vol.106 , Issue.5 , pp. 479-485
    • Baeza, N.1    Weller, M.2    Yonekawa, Y.3    Kleihues, P.4    Ohgaki, H.5
  • 7
    • 0037389849 scopus 로고    scopus 로고
    • 6-methyl-guanine-DNA methyltransferase methylation in serum and tumor DNA predicts response to 1,3-bis(2-chloroethyl)-l-nitrosourea but not to temozolamide plus cisplatin in glioblastoma multiforme
    • Balaña C, Ramirez JL, Taron M, Roussos Y, Ariza A, Ballester R, et al, (2003) O6-methyl-guanine-DNA methyltransferase methylation in serum and tumor DNA predicts response to 1,3-bis(2-chloroethyl)-1-nitrosourea but not to temozolamide plus cisplatin in glioblastoma multiforme. Clin Cancer Res 9: 1461-1468. (Pubitemid 36418402)
    • (2003) Clinical Cancer Research , vol.9 , Issue.4 , pp. 1461-1468
    • Balana, C.1    Ramirez, J.L.2    Taron, M.3    Roussos, Y.4    Ariza, A.5    Ballester, R.6    Sarries, C.7    Mendez, P.8    Sanchez, J.J.9    Rosell, R.10
  • 9
    • 79952534189 scopus 로고    scopus 로고
    • Regulation of chromatin by histone modifications
    • Bannister AJ, Kouzarides T, (2011) Regulation of chromatin by histone modifications. Cell Res 21: 381-395.
    • (2011) Cell Res , vol.21 , pp. 381-395
    • Bannister, A.J.1    Kouzarides, T.2
  • 10
    • 34249026300 scopus 로고    scopus 로고
    • High-Resolution Profiling of Histone Methylations in the Human Genome
    • DOI 10.1016/j.cell.2007.05.009, PII S0092867407006009
    • Barski A, Cuddapah S, Cui K, Roh T, Schones DE, Wang Z, et al, (2007) High-resolution profiling of histone methylations in the human genome. Cell 129: 823-837. (Pubitemid 46802390)
    • (2007) Cell , vol.129 , Issue.4 , pp. 823-837
    • Barski, A.1    Cuddapah, S.2    Cui, K.3    Roh, T.-Y.4    Schones, D.E.5    Wang, Z.6    Wei, G.7    Chepelev, I.8    Zhao, K.9
  • 11
    • 76049084596 scopus 로고    scopus 로고
    • Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma
    • Berdasco M, Ropero S, Setien F, Fraga MF, Lapunzina P, Losson R, et al, (2009) Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma. Proc Natl Acad Sci USA 106: 21830-21835.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 21830-21835
    • Berdasco, M.1    Ropero, S.2    Setien, F.3    Fraga, M.F.4    Lapunzina, P.5    Losson, R.6
  • 14
    • 56649097479 scopus 로고    scopus 로고
    • MethyQESD, a robust and fast method for quantitative methylation analyses in HNPCC diagnostics using formalin-fixed and paraffin-embedded tissue samples
    • Bettstetter M, Dechant S, Ruemmele P, Vogel C, Kurz K, Morak M, et al, (2008) MethyQESD, a robust and fast method for quantitative methylation analyses in HNPCC diagnostics using formalin-fixed and paraffin-embedded tissue samples. Lab Invest 88: 1367-1375.
    • (2008) Lab Invest , vol.88 , pp. 1367-1375
    • Bettstetter, M.1    Dechant, S.2    Ruemmele, P.3    Vogel, C.4    Kurz, K.5    Morak, M.6
  • 15
    • 33947317206 scopus 로고    scopus 로고
    • The epigenetic regulation of mammalian telomeres
    • DOI 10.1038/nrg2047, PII NRG2047
    • Blasco MA, (2007) The epigenetic regulation of mammalian telomeres. Nat Rev Genet 8: 299-309. (Pubitemid 46439289)
    • (2007) Nature Reviews Genetics , vol.8 , Issue.4 , pp. 299-309
    • Blasco, M.A.1
  • 16
    • 79953108690 scopus 로고    scopus 로고
    • Epigenetics in cancer: What's the future?
    • 228.
    • Boumber Y, Issa JJ, (2011) Epigenetics in cancer: what's the future? Oncology (Williston Park) 25: 220-226. 228.
    • (2011) Oncology (Williston Park) , vol.25 , pp. 220-226
    • Boumber, Y.1    Issa, J.J.2
  • 17
    • 33749039999 scopus 로고    scopus 로고
    • Genome-wide hypomethylation in human glioblastomas associated with specific copy number alteration, methylenetetrahydrofolate reductase allele status, and increased proliferation
    • DOI 10.1158/0008-5472.CAN-06-1547
    • Cadieux B, Ching T, Vandenberg SR, Costello JF, (2006) Genome-wide hypomethylation in human glioblastomas associated with specific copy number alteration, methylenetetrahydrofolate reductase allele status, and increased proliferation. Cancer Res 66: 8469-8476. (Pubitemid 44449159)
    • (2006) Cancer Research , vol.66 , Issue.17 , pp. 8469-8476
    • Cadieux, B.1    Ching, T.-T.2    VandenBerg, S.R.3    Costello, J.F.4
  • 18
    • 79952085666 scopus 로고    scopus 로고
    • Expression of nuclear receptor corepressors and class i histone deacetylases in astrocytic gliomas
    • Campos B, Bermejo JL, Han L, Felsberg J, Ahmadi R, Grabe N, et al, (2011) Expression of nuclear receptor corepressors and class I histone deacetylases in astrocytic gliomas. Cancer Sci 102: 387-392.
    • (2011) Cancer Sci , vol.102 , pp. 387-392
    • Campos, B.1    Bermejo, J.L.2    Han, L.3    Felsberg, J.4    Ahmadi, R.5    Grabe, N.6
  • 19
    • 79956294973 scopus 로고    scopus 로고
    • DNA methylation and demethylation in mammals
    • Chen Z, Riggs AD, (2011) DNA methylation and demethylation in mammals. J Biol Chem 286: 18347-18353.
    • (2011) J Biol Chem , vol.286 , pp. 18347-18353
    • Chen, Z.1    Riggs, A.D.2
  • 21
    • 0038678777 scopus 로고    scopus 로고
    • Sensitive and quantitative universal Pyrosequencing™ methylation analysis of CpG sites
    • Colella S, Shen L, Baggerly KA, Issa JP, Krahe R, (2003) Sensitive and quantitative universal Pyrosequencing methylation analysis of CpG sites. BioTechniques 35: 146-150. (Pubitemid 36828724)
    • (2003) BioTechniques , vol.35 , Issue.1 , pp. 146-150
    • Colella, S.1    Shen, L.2    Baggerly, K.A.3    Issa, J.-P.J.4    Krahe, R.5
  • 23
    • 79551612332 scopus 로고    scopus 로고
    • Asf1b, the necessary Asf1 isoform for proliferation, is predictive of outcome in breast cancer
    • Corpet A, Koning L, Toedling J, Savignoni A, Berger F, Lemaître C, et al, (2011) Asf1b, the necessary Asf1 isoform for proliferation, is predictive of outcome in breast cancer. EMBO J 30: 480-493.
    • (2011) EMBO J , vol.30 , pp. 480-493
    • Corpet, A.1    Koning, L.2    Toedling, J.3    Savignoni, A.4    Berger, F.5    Lemaître, C.6
  • 24
    • 76549121309 scopus 로고    scopus 로고
    • Reversing HOXA9 oncogene activation by PI3K inhibition: Epigenetic mechanism and prognostic significance in human glioblastoma
    • Costa BM, Smith JS, Chen Y, Chen J, Phillips HS, Aldape KD, et al, (2010) Reversing HOXA9 oncogene activation by PI3K inhibition: epigenetic mechanism and prognostic significance in human glioblastoma. Cancer Res 70: 453-462.
    • (2010) Cancer Res , vol.70 , pp. 453-462
    • Costa, B.M.1    Smith, J.S.2    Chen, Y.3    Chen, J.4    Phillips, H.S.5    Aldape, K.D.6
  • 25
    • 0029967152 scopus 로고    scopus 로고
    • Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation
    • Costello JF, Berger MS, Huang HS, Cavenee WK, (1996) Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation. Cancer Res 56: 2405-2410. (Pubitemid 26154090)
    • (1996) Cancer Research , vol.56 , Issue.10 , pp. 2405-2410
    • Costello, J.F.1    Berger, M.S.2    Huang, H.-J.S.3    Cavenee, W.K.4
  • 26
    • 79955004702 scopus 로고    scopus 로고
    • Advances in DNA methylation: 5-hydroxymethylcytosine revisited
    • Dahl C, Grànbäk K, Guldberg P, (2011) Advances in DNA methylation: 5-hydroxymethylcytosine revisited. Clin Chim Acta 412: 831-836.
    • (2011) Clin Chim Acta , vol.412 , pp. 831-836
    • Dahl, C.1    Grànbäk, K.2    Guldberg, P.3
  • 28
    • 70649095120 scopus 로고    scopus 로고
    • Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts
    • Doi A, Park I, Wen B, Murakami P, Aryee MJ, Irizarry R, et al, (2009) Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nat Genet 41: 1350-1353.
    • (2009) Nat Genet , vol.41 , pp. 1350-1353
    • Doi, A.1    Park, I.2    Wen, B.3    Murakami, P.4    Aryee, M.J.5    Irizarry, R.6
  • 29
    • 20444397430 scopus 로고    scopus 로고
    • Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF
    • DOI 10.1016/j.cell.2005.04.031, PII S0092867405004496
    • Dou Y, Milne TA, Tackett AJ, Smith ER, Fukuda A, Wysocka J, et al, (2005) Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Cell 121: 873-885. (Pubitemid 40806419)
    • (2005) Cell , vol.121 , Issue.6 , pp. 873-885
    • Dou, Y.1    Milne, T.A.2    Tackett, A.J.3    Smith, E.R.4    Fukuda, A.5    Wysocka, J.6    Allis, C.D.7    Chait, B.T.8    Hess, J.L.9    Roeder, R.G.10
  • 30
    • 80052748411 scopus 로고    scopus 로고
    • Retrospective protein expression and epigenetic inactivation studies of CDH1 in patients affected by low-grade glioma
    • D'Urso PI, D'Urso OF, Storelli C, Catapano G, Gianfreda CD, Montinaro A, et al, (2010) Retrospective protein expression and epigenetic inactivation studies of CDH1 in patients affected by low-grade glioma. J Neurooncol 104: 113-118.
    • (2010) J Neurooncol , vol.104 , pp. 113-118
    • D'Urso, P.I.1    D'Urso, O.F.2    Storelli, C.3    Catapano, G.4    Gianfreda, C.D.5    Montinaro, A.6
  • 32
    • 0242584454 scopus 로고    scopus 로고
    • Chromosomal instability and tumors promoted by DNA hypomethylation
    • DOI 10.1126/science.1083557
    • Eden A, Gaudet F, Waghmare A, Jaenisch R, (2003) Chromosomal instability and tumors promoted by DNA hypomethylation. Science 300: 455. (Pubitemid 36444319)
    • (2003) Science , vol.300 , Issue.5618 , pp. 455
    • Eden, A.1    Gaudet, F.2    Waghmare, A.3    Jaenisch, R.4
  • 33
    • 34147206651 scopus 로고    scopus 로고
    • In vivo efficacy of a novel histone deacetylase inhibitor in combination with radiation for the treatment of gliomas
    • DOI 10.1215/15228517-2006-032
    • Entin-Meer M, Yang X, Vandenberg SR, Lamborn KR, Nudelman A, Rephaeli A, et al, (2007) In vivo efficacy of a novel histone deacetylase inhibitor in combination with radiation for the treatment of gliomas. Neuro-Oncol 9: 82-88. (Pubitemid 46580309)
    • (2007) Neuro-Oncology , vol.9 , Issue.2 , pp. 82-88
    • Entin-Meer, M.1    Yang, X.2    VandenBerg, S.R.3    Lamborn, K.R.4    Nudelman, A.5    Rephaeli, A.6    Haas-Kogan, D.A.7
  • 34
    • 33947315736 scopus 로고    scopus 로고
    • Cancer epigenomics: DNA methylomes and histone-modification maps
    • DOI 10.1038/nrg2005, PII NRG2005
    • Esteller M, (2007) Cancer epigenomics: DNA methylomes and histone-modification maps. Nat Rev Genet 8: 286-298. (Pubitemid 46439286)
    • (2007) Nature Reviews Genetics , vol.8 , Issue.4 , pp. 286-298
    • Esteller, M.1
  • 35
    • 0035870248 scopus 로고    scopus 로고
    • A gene hypermethylation profile of human cancer
    • Esteller M, Corn PG, Baylin SB, Herman JG, (2001) A gene hypermethylation profile of human cancer. Cancer Res 61: 3225-3229. (Pubitemid 32695003)
    • (2001) Cancer Research , vol.61 , Issue.8 , pp. 3225-3229
    • Esteller, M.1    Corn, P.G.2    Baylin, S.B.3    Herman, J.G.4
  • 38
    • 80053545678 scopus 로고    scopus 로고
    • Mutations in epigenetic modifiers in myeloid malignancies and the prospect of novel epigenetic-targeted therapy
    • [Epub ahead of print; doi:10.1155/2012/469592].
    • Fathi AT, Abdel-Wahab O, (2012) Mutations in epigenetic modifiers in myeloid malignancies and the prospect of novel epigenetic-targeted therapy, Advances in Hematology [Epub ahead of print; doi:10.1155/2012/469592].
    • (2012) Advances in Hematology
    • Fathi, A.T.1    Abdel-Wahab, O.2
  • 39
    • 26644462391 scopus 로고    scopus 로고
    • Cancer epigenetics is no Mickey Mouse
    • DOI 10.1016/j.ccr.2005.09.014, PII S1535610805003028
    • Feinberg AP, (2005) Cancer epigenetics is no Mickey Mouse. Cancer Cell 8: 267-268. (Pubitemid 41443410)
    • (2005) Cancer Cell , vol.8 , Issue.4 , pp. 267-268
    • Feinberg, A.P.1
  • 40
    • 79958072588 scopus 로고    scopus 로고
    • Promoter methylation and expression of MGMT and the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2 in paired primary and recurrent glioblastomas
    • Felsberg J, Thon N, Eigenbrod S, Hentschel B, Sabel MC, Westphal M, et al, (2011) Promoter methylation and expression of MGMT and the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2 in paired primary and recurrent glioblastomas. Int J Cancer 129: 659-670.
    • (2011) Int J Cancer , vol.129 , pp. 659-670
    • Felsberg, J.1    Thon, N.2    Eigenbrod, S.3    Hentschel, B.4    Sabel, M.C.5    Westphal, M.6
  • 41
    • 78650019179 scopus 로고    scopus 로고
    • Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
    • Figueroa ME, Abdel-Wahab O, Lu C, Ward PS, Patel J, Shih A, et al, (2010) Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell 18: 553-567.
    • (2010) Cancer Cell , vol.18 , pp. 553-567
    • Figueroa, M.E.1    Abdel-Wahab, O.2    Lu, C.3    Ward, P.S.4    Patel, J.5    Shih, A.6
  • 43
    • 20144388146 scopus 로고    scopus 로고
    • Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer
    • Fraga MF, Ballestar E, Villar-Garea A, Boix-Chornet M, Espada J, Schotta G, et al, (2005) Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet 37: 391-400.
    • (2005) Nat Genet , vol.37 , pp. 391-400
    • Fraga, M.F.1    Ballestar, E.2    Villar-Garea, A.3    Boix-Chornet, M.4    Espada, J.5    Schotta, G.6
  • 44
    • 0026546877 scopus 로고
    • A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands
    • Frommer M, McDonald LE, Millar DS, Collis CM, Watt F, Grigg GW, et al, (1992) A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands. Proc Natl Acad Sci USA 89: 1827-1831.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 1827-1831
    • Frommer, M.1    McDonald, L.E.2    Millar, D.S.3    Collis, C.M.4    Watt, F.5    Grigg, G.W.6
  • 45
    • 65349141942 scopus 로고    scopus 로고
    • Phase II trial of vorinostat in recurrent glioblastoma multiforme: A north central cancer treatment group study
    • Galanis E, Jaeckle KA, Maurer MJ, Reid JM, Ames MM, Hardwick JS, et al, (2009) Phase II trial of vorinostat in recurrent glioblastoma multiforme: a north central cancer treatment group study. J Clin Oncol 27: 2052-2058.
    • (2009) J Clin Oncol , vol.27 , pp. 2052-2058
    • Galanis, E.1    Jaeckle, K.A.2    Maurer, M.J.3    Reid, J.M.4    Ames, M.M.5    Hardwick, J.S.6
  • 46
    • 1942469956 scopus 로고    scopus 로고
    • MGMT: Its role in cancer aetiology and cancer therapeutics
    • Gerson SL, (2004) MGMT: its role in cancer aetiology and cancer therapeutics. Nat Rev Cancer 4: 296-307. (Pubitemid 38525285)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.4 , pp. 296-307
    • Gerson, S.L.1
  • 47
    • 56449126945 scopus 로고    scopus 로고
    • Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal
    • Godlewski J, Nowicki MO, Bronisz A, Williams S, Otsuki A, Nuovo G, et al, (2008) Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal. Cancer Res 68: 9125-9130.
    • (2008) Cancer Res , vol.68 , pp. 9125-9130
    • Godlewski, J.1    Nowicki, M.O.2    Bronisz, A.3    Williams, S.4    Otsuki, A.5    Nuovo, G.6
  • 48
    • 74249095339 scopus 로고    scopus 로고
    • ECRG4 is a candidate tumor suppressor gene frequently hypermethylated in colorectal carcinoma and glioma
    • Götze S, Feldhaus V, Traska T, Wolter M, Reifenberger G, Tannapfel A, et al, (2009) ECRG4 is a candidate tumor suppressor gene frequently hypermethylated in colorectal carcinoma and glioma. BMC Cancer 9: 447.
    • (2009) BMC Cancer , vol.9 , pp. 447
    • Götze, S.1    Feldhaus, V.2    Traska, T.3    Wolter, M.4    Reifenberger, G.5    Tannapfel, A.6
  • 49
    • 77951247981 scopus 로고    scopus 로고
    • Frequent promoter hypermethylation of Wnt pathway inhibitor genes in malignant astrocytic gliomas
    • Götze S, Wolter M, Reifenberger G, Müller O, Sievers S, (2010) Frequent promoter hypermethylation of Wnt pathway inhibitor genes in malignant astrocytic gliomas. Int J Cancer 126: 2584-2593.
    • (2010) Int J Cancer , vol.126 , pp. 2584-2593
    • Götze, S.1    Wolter, M.2    Reifenberger, G.3    Müller, O.4    Sievers, S.5
  • 50
    • 80052266351 scopus 로고    scopus 로고
    • Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder
    • Gui Y, Guo G, Huang Y, Hu X, Tang A, Gao S, et al, (2011) Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder. Nat Genet 43: 875-878.
    • (2011) Nat Genet , vol.43 , pp. 875-878
    • Gui, Y.1    Guo, G.2    Huang, Y.3    Hu, X.4    Tang, A.5    Gao, S.6
  • 51
    • 79957975801 scopus 로고    scopus 로고
    • Nonsense mutation and inactivation of SMARCA4 (BRG1) in an atypical teratoid/rhabdoid tumor showing retained SMARCB1 (INI1) expression
    • Hasselblatt M, Gesk S, Oyen F, Rossi S, Viscardi E, Giangaspero F, et al, (2011) Nonsense mutation and inactivation of SMARCA4 (BRG1) in an atypical teratoid/rhabdoid tumor showing retained SMARCB1 (INI1) expression. Am J Surg Pathol 35: 933-935.
    • (2011) Am J Surg Pathol , vol.35 , pp. 933-935
    • Hasselblatt, M.1    Gesk, S.2    Oyen, F.3    Rossi, S.4    Viscardi, E.5    Giangaspero, F.6
  • 53
    • 80052495940 scopus 로고    scopus 로고
    • Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA
    • He Y, Li B, Li Z, Liu P, Wang Y, Tang Q, et al, (2011) Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science 333: 1303-1307.
    • (2011) Science , vol.333 , pp. 1303-1307
    • He, Y.1    Li, B.2    Li, Z.3    Liu, P.4    Wang, Y.5    Tang, Q.6
  • 56
    • 0344873729 scopus 로고    scopus 로고
    • Epigenetic inactivation of RASSF1A candidate tumor suppressor gene at 3p21.3 in brain tumors
    • DOI 10.1038/sj.onc.1207082
    • Horiguchi K, Tomizawa Y, Tosaka M, Ishiuchi S, Kurihara H, Mori M, et al, (2003) Epigenetic inactivation of RASSF1A candidate tumor suppressor gene at 3p21.3 in brain tumors. Oncogene 22: 7862-7865. (Pubitemid 37485546)
    • (2003) Oncogene , vol.22 , Issue.49 , pp. 7862-7865
    • Horiguchi, K.1    Tomizawa, Y.2    Tosaka, M.3    Ishiuchi, S.4    Kurihara, H.5    Mori, M.6    Saito, N.7
  • 57
    • 0033047813 scopus 로고    scopus 로고
    • Methylation profiling of CpG islands in human breast cancer cells
    • Huang TH, Perry MR, Laux DE, (1999) Methylation profiling of CpG islands in human breast cancer cells. Hum Mol Genet 8: 459-470. (Pubitemid 29097334)
    • (1999) Human Molecular Genetics , vol.8 , Issue.3 , pp. 459-470
    • Huang, T.H.-M.1    Perry, M.R.2    Laux, D.E.3
  • 58
    • 0024673303 scopus 로고
    • CpG methylation of the cAMP-responsive enhancer/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation
    • Iguchi-Ariga SM, Schaffner W, (1989) CpG methylation of the cAMP-responsive enhancer/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation. Genes Dev 3: 612-619.
    • (1989) Genes Dev , vol.3 , pp. 612-619
    • Iguchi-Ariga, S.M.1    Schaffner, W.2
  • 59
    • 59149084538 scopus 로고    scopus 로고
    • The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores
    • Irizarry RA, Ladd-Acosta C, Wen B, Wu Z, Montano C, Onyango P, et al, (2009) The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet 41: 178-186.
    • (2009) Nat Genet , vol.41 , pp. 178-186
    • Irizarry, R.A.1    Ladd-Acosta, C.2    Wen, B.3    Wu, Z.4    Montano, C.5    Onyango, P.6
  • 60
    • 10344260184 scopus 로고    scopus 로고
    • CpG island methylator phenotype in cancer
    • DOI 10.1038/nrc1507
    • Issa J, (2004) CpG island methylator phenotype in cancer. Nat Rev Cancer 4: 988-993. (Pubitemid 39626222)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.12 , pp. 988-993
    • Issa, J.-P.1
  • 62
    • 79952279828 scopus 로고    scopus 로고
    • DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors
    • Jiao Y, Shi C, Edil BH, de Wilde RF, Klimstra DS, Maitra A, et al, (2011) DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science 331: 1199-1203.
    • (2011) Science , vol.331 , pp. 1199-1203
    • Jiao, Y.1    Shi, C.2    Edil, B.H.3    De Wilde, R.F.4    Klimstra, D.S.5    Maitra, A.6
  • 63
    • 77954362183 scopus 로고    scopus 로고
    • Examination of the specificity of DNA methylation profiling techniques towards 5-methylcytosine and 5-hydroxymethylcytosine
    • Jin S, Kadam S, Pfeifer GP, (2010) Examination of the specificity of DNA methylation profiling techniques towards 5-methylcytosine and 5-hydroxymethylcytosine. Nucleic Acids Res 38: e125.
    • (2010) Nucleic Acids Res , vol.38
    • Jin, S.1    Kadam, S.2    Pfeifer, G.P.3
  • 64
    • 79955043488 scopus 로고    scopus 로고
    • Recent advances in X-chromosome inactivation
    • Kalantry S, (2011) Recent advances in X-chromosome inactivation. J Cell Physiol 226: 1714-1718.
    • (2011) J Cell Physiol , vol.226 , pp. 1714-1718
    • Kalantry, S.1
  • 65
  • 66
    • 55849135596 scopus 로고    scopus 로고
    • MicroRNA-directed transcriptional gene silencing in mammalian cells
    • Kim DH, Saetrom P, Snàve O, Rossi JJ, (2008) MicroRNA-directed transcriptional gene silencing in mammalian cells. Proc Natl Acad Sci USA 105: 16230-16235.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 16230-16235
    • Kim, D.H.1    Saetrom, P.2    Snàve, O.3    Rossi, J.J.4
  • 68
    • 1642391063 scopus 로고    scopus 로고
    • Hypermethylation and transcriptional downregulation of the carboxyl-terminal modulator protein gene in glioblastomas
    • Knobbe CB, Reifenberger J, Blaschke B, Reifenberger G, (2004) Hypermethylation and transcriptional downregulation of the carboxyl-terminal modulator protein gene in glioblastomas. J Natl Cancer Inst 96: 483-486. (Pubitemid 38443652)
    • (2004) Journal of the National Cancer Institute , vol.96 , Issue.6 , pp. 483-486
    • Knobbe, C.B.1    Reifenberger, J.2    Blaschke, B.3    Reifenberger, G.4
  • 69
    • 79952113300 scopus 로고    scopus 로고
    • Nucleosome dynamics and epigenetic stability
    • Korber P, Becker PB, (2010) Nucleosome dynamics and epigenetic stability. Essays Biochem 48: 63-74.
    • (2010) Essays Biochem , vol.48 , pp. 63-74
    • Korber, P.1    Becker, P.B.2
  • 70
    • 66149123748 scopus 로고    scopus 로고
    • The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain
    • Kriaucionis S, Heintz N, (2009) The nuclear DNA base 5- hydroxymethylcytosine is present in Purkinje neurons and the brain. Science 324: 929-930.
    • (2009) Science , vol.324 , pp. 929-930
    • Kriaucionis, S.1    Heintz, N.2
  • 71
    • 77957366305 scopus 로고    scopus 로고
    • DNA methylation and cancer
    • Kulis M, Esteller M, (2010) DNA methylation and cancer. Adv Genet 70: 27-56.
    • (2010) Adv Genet , vol.70 , pp. 27-56
    • Kulis, M.1    Esteller, M.2
  • 72
    • 82755161786 scopus 로고    scopus 로고
    • Epigenetic regulation of microRNAs in cancer: An integrated review of literature
    • [Epub ahead of print].
    • Kunej T, Godnic I, Ferdin J, Horvat S, Dovc P, Calin GA, (2011) Epigenetic regulation of microRNAs in cancer: an integrated review of literature. Mutat Res [Epub ahead of print].
    • (2011) Mutat Res
    • Kunej, T.1    Godnic, I.2    Ferdin, J.3    Horvat, S.4    Dovc, P.5    Calin, G.A.6
  • 74
    • 79951611375 scopus 로고    scopus 로고
    • Methylation profiling identifies 2 groups of gliomas according to their tumorigenesis
    • Laffaire J, Everhard S, Idbaih A, Crinière E, Marie Y, Reyniès A, et al, (2011) Methylation profiling identifies 2 groups of gliomas according to their tumorigenesis. Neuro-Oncol 13: 84-98.
    • (2011) Neuro-Oncol , vol.13 , pp. 84-98
    • Laffaire, J.1    Everhard, S.2    Idbaih, A.3    Crinière, E.4    Marie, Y.5    Reyniès, A.6
  • 75
    • 75849139815 scopus 로고    scopus 로고
    • Serum DNA can define tumor-specific genetic and epigenetic markers in gliomas of various grades
    • Lavon I, Refael M, Zelikovitch B, Shalom E, Siegal T, (2010) Serum DNA can define tumor-specific genetic and epigenetic markers in gliomas of various grades. Neuro-Oncol 12: 173-180.
    • (2010) Neuro-Oncol , vol.12 , pp. 173-180
    • Lavon, I.1    Refael, M.2    Zelikovitch, B.3    Shalom, E.4    Siegal, T.5
  • 77
    • 79952535798 scopus 로고    scopus 로고
    • Genomic imprinting in mammals: Its life cycle, molecular mechanisms and reprogramming
    • Li Y, Sasaki H, (2011) Genomic imprinting in mammals: its life cycle, molecular mechanisms and reprogramming. Cell Res 21: 466-473.
    • (2011) Cell Res , vol.21 , pp. 466-473
    • Li, Y.1    Sasaki, H.2
  • 78
    • 33847070442 scopus 로고    scopus 로고
    • The Role of Chromatin during Transcription
    • DOI 10.1016/j.cell.2007.01.015, PII S0092867407001092
    • Li B, Carey M, Workman JL, (2007) The role of chromatin during transcription. Cell 128: 707-719. (Pubitemid 46273570)
    • (2007) Cell , vol.128 , Issue.4 , pp. 707-719
    • Li, B.1    Carey, M.2    Workman, J.L.3
  • 79
    • 79960846309 scopus 로고    scopus 로고
    • SOCS3 promoter methylation is mutually exclusive to EGFR amplification in gliomas and promotes glioma cell invasion through STAT3 and FAK activation
    • Lindemann C, Hackmann O, Delic S, Schmidt N, Reifenberger G, Riemenschneider MJ, (2011) SOCS3 promoter methylation is mutually exclusive to EGFR amplification in gliomas and promotes glioma cell invasion through STAT3 and FAK activation. Acta Neuropathol 122 (2): 241-251.
    • (2011) Acta Neuropathol , vol.122 , Issue.2 , pp. 241-251
    • Lindemann, C.1    Hackmann, O.2    Delic, S.3    Schmidt, N.4    Reifenberger, G.5    Riemenschneider, M.J.6
  • 80
    • 78549286057 scopus 로고    scopus 로고
    • Global histone modification patterns as prognostic markers to classify glioma patients
    • Liu B, Cheng J, Zhang X, Wang R, Zhang W, Lin H, et al, (2010) Global histone modification patterns as prognostic markers to classify glioma patients. Cancer Epidemiol Biomarkers Prev 19: 2888-2896.
    • (2010) Cancer Epidemiol Biomarkers Prev , vol.19 , pp. 2888-2896
    • Liu, B.1    Cheng, J.2    Zhang, X.3    Wang, R.4    Zhang, W.5    Lin, H.6
  • 81
    • 77957058258 scopus 로고    scopus 로고
    • Quantitative detection of multiple gene promoter hypermethylation in tumor tissue, serum, and cerebrospinal fluid predicts prognosis of malignant gliomas
    • Liu B, Cheng J, Zhang W, Zhang X, Wang R, Lin H, et al, (2010) Quantitative detection of multiple gene promoter hypermethylation in tumor tissue, serum, and cerebrospinal fluid predicts prognosis of malignant gliomas. Neuro-Oncol 12: 540-548.
    • (2010) Neuro-Oncol , vol.12 , pp. 540-548
    • Liu, B.1    Cheng, J.2    Zhang, W.3    Zhang, X.4    Wang, R.5    Lin, H.6
  • 82
    • 0035839135 scopus 로고    scopus 로고
    • Snf1 - A histone kinase that works in concert with the histone acetyltransferase Gcn5 to regulate transcription
    • DOI 10.1126/science.1062322
    • Lo WS, Duggan L, Emre NC, Belotserkovskya R, Lane WS, Shiekhattar R, et al, (2001) Snf1-a histone kinase that works in concert with the histone acetyltransferase Gcn5 to regulate transcription. Science 293: 1142-1146. (Pubitemid 32758096)
    • (2001) Science , vol.293 , Issue.5532 , pp. 1142-1146
    • Lo, W.-S.1    Duggan, L.2    Emre, N.C.T.3    Belotserkovskya, R.4    Lane, W.S.5    Shiekhattar, R.6    Berger, S.L.7
  • 83
    • 61649089532 scopus 로고    scopus 로고
    • RASSF1A, BLU, NORE1A, PTEN and MGMT expression and promoter methylation in gliomas and glioma cell lines and evidence of deregulated expression of de novo DNMTs
    • Lorente A, Mueller W, Urdangarín E, Lázcoz P, Lass U, von Deimling A, et al, (2009) RASSF1A, BLU, NORE1A, PTEN and MGMT expression and promoter methylation in gliomas and glioma cell lines and evidence of deregulated expression of de novo DNMTs. Brain Pathol 19: 279-292.
    • (2009) Brain Pathol , vol.19 , pp. 279-292
    • Lorente, A.1    Mueller, W.2    Urdangarín, E.3    Lázcoz, P.4    Lass, U.5    Von Deimling, A.6
  • 84
    • 52249090461 scopus 로고    scopus 로고
    • Differential expression of 12 histone deacetylase (HDAC) genes in astrocytomas and normal brain tissue: Class II and IV are hypoexpressed in glioblastomas
    • Lucio-Eterovic AKB, Cortez MAA, Valera ET, Motta FJN, Queiroz RGP, Machado HR, et al, (2008) Differential expression of 12 histone deacetylase (HDAC) genes in astrocytomas and normal brain tissue: class II and IV are hypoexpressed in glioblastomas. BMC Cancer 8: 243.
    • (2008) BMC Cancer , vol.8 , pp. 243
    • Lucio-Eterovic, A.K.B.1    Cortez, M.A.A.2    Valera, E.T.3    Motta, F.J.N.4    Queiroz, R.G.P.5    MacHado, H.R.6
  • 86
    • 77952888433 scopus 로고    scopus 로고
    • The DNA methylome of glioblastoma multiforme
    • Martinez R, Esteller M, (2010) The DNA methylome of glioblastoma multiforme. Neurobiol Dis 39: 40-46.
    • (2010) Neurobiol Dis , vol.39 , pp. 40-46
    • Martinez, R.1    Esteller, M.2
  • 87
    • 0242300612 scopus 로고    scopus 로고
    • DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation
    • DOI 10.1126/science.1090842
    • Martinowich K, Hattori D, Wu H, Fouse S, He F, Hu Y, et al, (2003) DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science 302: 890-893. (Pubitemid 37339633)
    • (2003) Science , vol.302 , Issue.5646 , pp. 890-893
    • Martinowich, K.1    Hattori, D.2    Wu, H.3    Fouse, S.4    He, F.5    Hu, Y.6    Fan, G.7    Sun, Y.E.8
  • 89
    • 49649125042 scopus 로고    scopus 로고
    • Genome-scale DNA methylation maps of pluripotent and differentiated cells
    • Meissner A, Mikkelsen TS, Gu H, Wernig M, Hanna J, Sivachenko A, et al, (2008) Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature 454: 766-770.
    • (2008) Nature , vol.454 , pp. 766-770
    • Meissner, A.1    Mikkelsen, T.S.2    Gu, H.3    Wernig, M.4    Hanna, J.5    Sivachenko, A.6
  • 90
    • 0031440948 scopus 로고    scopus 로고
    • Budding yeast centromere composition and assembly as revealed by in vivo cross-linking
    • Meluh PB, Koshland D, (1997) Budding yeast centromere composition and assembly as revealed by in vivo cross-linking. Genes Dev 11: 3401-3412. (Pubitemid 28023962)
    • (1997) Genes and Development , vol.11 , Issue.24 , pp. 3401-3412
    • Meluh, P.B.1    Koshland, D.2
  • 92
    • 51649129596 scopus 로고    scopus 로고
    • Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors
    • Mohn F, Weber M, Rebhan M, Roloff TC, Richter J, Stadler MB, et al, (2008) Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors. Mol Cell 30: 755-766.
    • (2008) Mol Cell , vol.30 , pp. 755-766
    • Mohn, F.1    Weber, M.2    Rebhan, M.3    Roloff, T.C.4    Richter, J.5    Stadler, M.B.6
  • 94
    • 58249096131 scopus 로고    scopus 로고
    • HDAC4 represses p21(WAF1/Cip1) expression in human cancer cells through a Sp1-dependent, p53-independent mechanism
    • Mottet D, Pirotte S, Lamour V, Hagedorn M, Javerzat S, Bikfalvi A, et al, (2009) HDAC4 represses p21(WAF1/Cip1) expression in human cancer cells through a Sp1-dependent, p53-independent mechanism. Oncogene 28: 243-256.
    • (2009) Oncogene , vol.28 , pp. 243-256
    • Mottet, D.1    Pirotte, S.2    Lamour, V.3    Hagedorn, M.4    Javerzat, S.5    Bikfalvi, A.6
  • 95
    • 77957339220 scopus 로고    scopus 로고
    • Interplay between different epigenetic modifications and mechanisms
    • Murr R, (2010) Interplay between different epigenetic modifications and mechanisms. Adv Genet 70: 101-141.
    • (2010) Adv Genet , vol.70 , pp. 101-141
    • Murr, R.1
  • 96
    • 0034795045 scopus 로고    scopus 로고
    • Promoter methylation of the DNA repair gene MGMT in astrocytomas is frequently associated with G:C → A:T mutations of the TP53 tumor suppressor gene
    • Nakamura M, Watanabe T, Yonekawa Y, Kleihues P, Ohgaki H, (2001) Promoter methylation of the DNA repair gene MGMT in astrocytomas is frequently associated with G:C-A:T mutations of the TP53 tumor suppressor gene. Carcinogenesis 22: 1715-1719. (Pubitemid 32952152)
    • (2001) Carcinogenesis , vol.22 , Issue.10 , pp. 1715-1719
    • Nakamura, M.1    Watanabe, T.2    Yonekawa, Y.3    Kleihues, P.4    Ohgaki, H.5
  • 99
    • 13444269098 scopus 로고    scopus 로고
    • Frequent LOH on 22q12.3 and TIMP-3 inactivation occur in the progression to secondary glioblastomas
    • DOI 10.1038/labinvest.3700223
    • Nakamura M, Ishida E, Shimada K, Kishi M, Nakase H, Sakaki T, et al, (2005) Frequent LOH on 22q12.3 and TIMP-3 inactivation occur in the progression to secondary glioblastomas. Lab Invest 85: 165-175. (Pubitemid 40208920)
    • (2005) Laboratory Investigation , vol.85 , Issue.2 , pp. 165-175
    • Nakamura, M.1    Ishida, E.2    Shimada, K.3    Kishi, M.4    Nakase, H.5    Sakaki, T.6    Konishi, N.7
  • 100
    • 0035815360 scopus 로고    scopus 로고
    • Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly
    • DOI 10.1126/science.1060118
    • Nakayama J, Rice JC, Strahl BD, Allis CD, Grewal SI, (2001) Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly. Science 292: 110-113. (Pubitemid 32289138)
    • (2001) Science , vol.292 , Issue.5514 , pp. 110-113
    • Nakayama, J.1    Rice, J.C.2    Strahl, B.D.3    Allis, C.D.4    Grewal, S.I.S.5
  • 101
  • 102
    • 24044464247 scopus 로고    scopus 로고
    • Methylation-specific MLPA (MS-MLPA): Simultaneous detection of CpG methylation and copy number changes of up to 40 sequences
    • Nygren AOH, Ameziane N, Duarte HMB, Vijzelaar RNCP, Waisfisz Q, Hess CJ, et al, (2005) Methylation-specific MLPA (MS-MLPA): simultaneous detection of CpG methylation and copy number changes of up to 40 sequences. Nucleic Acids Res 33: e128.
    • (2005) Nucleic Acids Res , vol.33
    • Nygren, A.O.H.1    Ameziane, N.2    Duarte, H.M.B.3    Vijzelaar, R.4    Waisfisz, Q.5    Hess, C.J.6
  • 103
    • 79961151346 scopus 로고    scopus 로고
    • The Global DNA Methylation Surrogate LINE-1 Methylation Is Correlated with MGMT Promoter Methylation and Is a Better Prognostic Factor for Glioma
    • Ohka F, Natsume A, Motomura K, Kishida Y, Kondo Y, Abe T, et al, (2011) The Global DNA Methylation Surrogate LINE-1 Methylation Is Correlated with MGMT Promoter Methylation and Is a Better Prognostic Factor for Glioma. PLoS ONE 6: e23332.
    • (2011) PLoS ONE , vol.6
    • Ohka, F.1    Natsume, A.2    Motomura, K.3    Kishida, Y.4    Kondo, Y.5    Abe, T.6
  • 105
    • 58249121980 scopus 로고    scopus 로고
    • Temozolomide and carmustine cause large-scale heterochromatin reorganization in glioma cells
    • Papait R, Magrassi L, Rigamonti D, Cattaneo E, (2009) Temozolomide and carmustine cause large-scale heterochromatin reorganization in glioma cells. Biochem Biophys Res Commun 379: 434-439.
    • (2009) Biochem Biophys Res Commun , vol.379 , pp. 434-439
    • Papait, R.1    Magrassi, L.2    Rigamonti, D.3    Cattaneo, E.4
  • 107
    • 79251629946 scopus 로고    scopus 로고
    • The genetic landscape of the childhood cancer medulloblastoma
    • Parsons DW, Li M, Zhang X, Jones S, Leary RJ, Lin JC, et al, (2011) The genetic landscape of the childhood cancer medulloblastoma. Science 331: 435-439.
    • (2011) Science , vol.331 , pp. 435-439
    • Parsons, D.W.1    Li, M.2    Zhang, X.3    Jones, S.4    Leary, R.J.5    Lin, J.C.6
  • 109
    • 27744443057 scopus 로고    scopus 로고
    • Methylated-CpG island recovery assay: A new technique for the rapid detection of methylated-CpG islands in cancer
    • DOI 10.1038/labinvest.3700311
    • Rauch T, Pfeifer GP, (2005) Methylated-CpG island recovery assay: a new technique for the rapid detection of methylated-CpG islands in cancer. Lab Invest 85: 1172-1180. (Pubitemid 43073989)
    • (2005) Laboratory Investigation , vol.85 , Issue.9 , pp. 1172-1180
    • Rauch, T.1    Pfeifer, G.P.2
  • 111
    • 77954697566 scopus 로고    scopus 로고
    • Isocitrate dehydrogenase 1 and 2 mutations in cancer: Alterations at a crossroads of cellular metabolism
    • Reitman ZJ, Yan H, (2010) Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism. J Natl Cancer Inst 102: 932-941.
    • (2010) J Natl Cancer Inst , vol.102 , pp. 932-941
    • Reitman, Z.J.1    Yan, H.2
  • 112
    • 79952741730 scopus 로고    scopus 로고
    • Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome
    • Reitman ZJ, Jin G, Karoly ED, Spasojevic I, Yang J, Kinzler KW, et al, (2011) Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome. Proc Natl Acad Sci USA 108: 3270-3275.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 3270-3275
    • Reitman, Z.J.1    Jin, G.2    Karoly, E.D.3    Spasojevic, I.4    Yang, J.5    Kinzler, K.W.6
  • 114
    • 42549135582 scopus 로고    scopus 로고
    • Frequent biallelic inactivation and transcriptional silencing of the DIRAS3 gene at 1p31 in oligodendroglial tumors with 1p loss
    • DOI 10.1002/ijc.23409
    • Riemenschneider MJ, Reifenberger J, Reifenberger G, (2008) Frequent biallelic inactivation and transcriptional silencing of the DIRAS3 gene at 1p31 in oligodendroglial tumors with 1p loss. Int J Cancer 122: 2503-2510. (Pubitemid 351590483)
    • (2008) International Journal of Cancer , vol.122 , Issue.11 , pp. 2503-2510
    • Riemenschneider, M.J.1    Reifenberger, J.2    Reifenberger, G.3
  • 117
    • 79952384705 scopus 로고    scopus 로고
    • Cancer epigenetics reaches mainstream oncology
    • Rodríguez-Paredes M, Esteller M, (2011) Cancer epigenetics reaches mainstream oncology. Nat Med 17: 330-339.
    • (2011) Nat Med , vol.17 , pp. 330-339
    • Rodríguez-Paredes, M.1    Esteller, M.2
  • 119
    • 80054701081 scopus 로고    scopus 로고
    • DNA hypermethylation and histone modifications downregulate the candidate tumor suppressor gene RRP22 on 22q12 in human gliomas
    • (Zurich, Switzerland)
    • Schmidt N, Windmann S, Reifenberger G, Riemenschneider MJ, (2011) DNA hypermethylation and histone modifications downregulate the candidate tumor suppressor gene RRP22 on 22q12 in human gliomas. Brain pathology (Zurich, Switzerland).
    • (2011) Brain Pathology
    • Schmidt, N.1    Windmann, S.2    Reifenberger, G.3    Riemenschneider, M.J.4
  • 120
    • 78649630221 scopus 로고    scopus 로고
    • Epigenomics of centromere assembly and function
    • Stimpson KM, Sullivan BA, (2010) Epigenomics of centromere assembly and function. Curr Opin Cell Biol 22: 772-780.
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 772-780
    • Stimpson, K.M.1    Sullivan, B.A.2
  • 123
    • 43749098985 scopus 로고    scopus 로고
    • DNA methylation landscapes: Provocative insights from epigenomics
    • DOI 10.1038/nrg2341, PII NRG2341
    • Suzuki MM, Bird A, (2008) DNA methylation landscapes: provocative insights from epigenomics. Nat Rev Genet 9: 465-476. (Pubitemid 351693975)
    • (2008) Nature Reviews Genetics , vol.9 , Issue.6 , pp. 465-476
    • Suzuki, M.M.1    Bird, A.2
  • 124
    • 66149146320 scopus 로고    scopus 로고
    • Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
    • Tahiliani M, Koh KP, Shen Y, Pastor WA, Bandukwala H, Brudno Y, et al, (2009) Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 324: 930-935.
    • (2009) Science , vol.324 , pp. 930-935
    • Tahiliani, M.1    Koh, K.P.2    Shen, Y.3    Pastor, W.A.4    Bandukwala, H.5    Brudno, Y.6
  • 125
    • 77949874234 scopus 로고    scopus 로고
    • Histone variants-ancient wrap artists of the epigenome
    • Talbert PB, Henikoff S, (2010) Histone variants-ancient wrap artists of the epigenome. Nat Rev Mol Cell Biol 11: 264-275.
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 264-275
    • Talbert, P.B.1    Henikoff, S.2
  • 126
    • 51649111238 scopus 로고    scopus 로고
    • Frequent promoter hypermethylation and transcriptional downregulation of the NDRG2 gene at 14q11.2 in primary glioblastoma
    • Tepel M, Roerig P, Wolter M, Gutmann DH, Perry A, Reifenberger G, et al, (2008) Frequent promoter hypermethylation and transcriptional downregulation of the NDRG2 gene at 14q11.2 in primary glioblastoma. Int J Cancer 123: 2080-2086.
    • (2008) Int J Cancer , vol.123 , pp. 2080-2086
    • Tepel, M.1    Roerig, P.2    Wolter, M.3    Gutmann, D.H.4    Perry, A.5    Reifenberger, G.6
  • 128
    • 0038002236 scopus 로고    scopus 로고
    • Analysis and quantification of multiple methylation variable positions in CpG islands by Pyrosequencing™
    • Tost J, Dunker J, Gut IG, (2003) Analysis and quantification of multiple methylation variable positions in CpG islands by Pyrosequencing. BioTechniques 35: 152-156. (Pubitemid 36828725)
    • (2003) BioTechniques , vol.35 , Issue.1 , pp. 152-156
    • Tost, J.1    Dunker, J.2    Gut, I.G.3
  • 129
    • 0033563165 scopus 로고    scopus 로고
    • Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification
    • Toyota M, Ho C, Ahuja N, Jair KW, Li Q, Ohe-Toyota M, et al, (1999) Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification. Cancer Res 59: 2307-2312. (Pubitemid 29242273)
    • (1999) Cancer Research , vol.59 , Issue.10 , pp. 2307-2312
    • Toyota, M.1    Ho, C.2    Ahuja, N.3    Jair, K.-W.4    Li, Q.5    Ohe-Toyota, M.6    Baylin, S.B.7    Issa, J.-P.J.8
  • 130
    • 78650353481 scopus 로고    scopus 로고
    • TRIM24 links a non-canonical histone signature to breast cancer
    • Tsai W, Wang Z, Yiu TT, Akdemir KC, Xia W, Winter S, et al, (2010) TRIM24 links a non-canonical histone signature to breast cancer. Nature 468: 927-932.
    • (2010) Nature , vol.468 , pp. 927-932
    • Tsai, W.1    Wang, Z.2    Yiu, T.T.3    Akdemir, K.C.4    Xia, W.5    Winter, S.6
  • 132
    • 7044245474 scopus 로고    scopus 로고
    • ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain
    • DOI 10.1038/sj.onc.1208053
    • Unoki M, Nishidate T, Nakamura Y, (2004) ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain. Oncogene 23: 7601-7610. (Pubitemid 39424918)
    • (2004) Oncogene , vol.23 , Issue.46 , pp. 7601-7610
    • Unoki, M.1    Nishidate, T.2    Nakamura, Y.3
  • 133
    • 77649122144 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: A report of the European Organization for Research and Treatment of Cancer Brain Tumor Group
    • van den Bent MJ, Dubbink HJ, Marie Y, Brandes AA, Taphoorn MJB, Wesseling P, et al, (2010) IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treatment of Cancer Brain Tumor Group. Clin Cancer Res 16: 1597-1604.
    • (2010) Clin Cancer Res , vol.16 , pp. 1597-1604
    • Van Den Bent, M.J.1    Dubbink, H.J.2    Marie, Y.3    Brandes, A.A.4    Taphoorn, M.J.B.5    Wesseling, P.6
  • 134
    • 79251635938 scopus 로고    scopus 로고
    • Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
    • Varela I, Tarpey P, Raine K, Huang D, Ong CK, Stephens P, et al, (2011) Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature 469: 539-542.
    • (2011) Nature , vol.469 , pp. 539-542
    • Varela, I.1    Tarpey, P.2    Raine, K.3    Huang, D.4    Ong, C.K.5    Stephens, P.6
  • 135
    • 73649123907 scopus 로고    scopus 로고
    • Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
    • Verhaak RGW, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD, et al, (2010) Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 17: 98-110.
    • (2010) Cancer Cell , vol.17 , pp. 98-110
    • Verhaak, R.G.W.1    Hoadley, K.A.2    Purdom, E.3    Wang, V.4    Qi, Y.5    Wilkerson, M.D.6
  • 136
    • 0035962668 scopus 로고    scopus 로고
    • Methyl CpG binding proteins: Coupling chromatin architecture to gene regulation
    • DOI 10.1038/sj.onc.1204340
    • Wade PA, (2001) Methyl CpG binding proteins: coupling chromatin architecture to gene regulation. Oncogene 20: 3166-3173. (Pubitemid 32553572)
    • (2001) Oncogene , vol.20 , Issue.24 REV. ISS. 3 , pp. 3166-3173
    • Wade, P.A.1
  • 138
    • 2442684104 scopus 로고    scopus 로고
    • An evaluation of new criteria for CpG islands in the human genome as gene markers
    • DOI 10.1093/bioinformatics/bth059
    • Wang Y, Leung FCC, (2004) An evaluation of new criteria for CpG islands in the human genome as gene markers. Bioinformatics 20: 1170-1177. (Pubitemid 38660354)
    • (2004) Bioinformatics , vol.20 , Issue.7 , pp. 1170-1177
    • Wang, Y.1    Leung, F.C.C.2
  • 139
    • 74749085364 scopus 로고    scopus 로고
    • Chk2 down-regulation by promoter hypermethylation in human bulk gliomas
    • Wang H, Wang S, Shen L, Chen Y, Zhang X, Zhou J, et al, (2010) Chk2 down-regulation by promoter hypermethylation in human bulk gliomas. Life Sci 86: 185-191.
    • (2010) Life Sci , vol.86 , pp. 185-191
    • Wang, H.1    Wang, S.2    Shen, L.3    Chen, Y.4    Zhang, X.5    Zhou, J.6
  • 140
    • 0033758181 scopus 로고    scopus 로고
    • Promoter demethylation accompanies reactivation of the HOX11 proto-oncogene in leukemia
    • Watt PM, Kumar R, Kees UR, (2000) Promoter demethylation accompanies reactivation of the HOX11 proto-oncogene in leukemia. Genes Chromosomes Cancer 29: 371-377.
    • (2000) Genes Chromosomes Cancer , vol.29 , pp. 371-377
    • Watt, P.M.1    Kumar, R.2    Kees, U.R.3
  • 141
    • 23044514626 scopus 로고    scopus 로고
    • Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells
    • DOI 10.1038/ng1598
    • Weber M, Davies JJ, Wittig D, Oakeley EJ, Haase M, Lam WL, et al, (2005) Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells. Nat Genet 37: 853-862. (Pubitemid 41077111)
    • (2005) Nature Genetics , vol.37 , Issue.8 , pp. 853-862
    • Weber, M.1    Davies, J.J.2    Wittig, D.3    Oakeley, E.J.4    Haase, M.5    Lam, W.L.6    Schubeler, D.7
  • 143
    • 80054705372 scopus 로고    scopus 로고
    • Prolonged survival with valproic acid use in the EORTC/NCIC temozolomide trial for glioblastoma
    • Weller M, Gorlia T, Cairncross JG, van den Bent MJ, Mason W, Belanger K, et al, (2011) Prolonged survival with valproic acid use in the EORTC/NCIC temozolomide trial for glioblastoma. Neurology 77: 1156-1164.
    • (2011) Neurology , vol.77 , pp. 1156-1164
    • Weller, M.1    Gorlia, T.2    Cairncross, J.G.3    Van Den Bent, M.J.4    Mason, W.5    Belanger, K.6
  • 144
    • 73349134695 scopus 로고    scopus 로고
    • NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with procarbazine, lomustine, and vincristine or temozolomide
    • Wick W, Hartmann C, Engel C, Stoffels M, Felsberg J, Stockhammer F, et al, (2009) NOA-04 randomized phase III trial of sequential radiochemotherapy of anaplastic glioma with procarbazine, lomustine, and vincristine or temozolomide. J Clin Oncol 27: 5874-5880.
    • (2009) J Clin Oncol , vol.27 , pp. 5874-5880
    • Wick, W.1    Hartmann, C.2    Engel, C.3    Stoffels, M.4    Felsberg, J.5    Stockhammer, F.6
  • 145
    • 79959653996 scopus 로고    scopus 로고
    • SWI/SNF nucleosome remodellers and cancer
    • Wilson BG, Roberts CWM, (2011) SWI/SNF nucleosome remodellers and cancer. Nat Rev Cancer 11: 481-492.
    • (2011) Nat Rev Cancer , vol.11 , pp. 481-492
    • Wilson, B.G.1    Roberts, C.W.M.2
  • 147
    • 77956095231 scopus 로고    scopus 로고
    • Active DNA demethylation: Many roads lead to Rome
    • Wu SC, Zhang Y, (2010) Active DNA demethylation: many roads lead to Rome. Nat Rev Mol Cell Biol 11: 607-620.
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 607-620
    • Wu, S.C.1    Zhang, Y.2
  • 148
    • 0030825309 scopus 로고    scopus 로고
    • COBRA: A sensitive and quantitative DNA methylation assay
    • DOI 10.1093/nar/25.12.2532
    • Xiong Z, Laird PW, (1997) COBRA: a sensitive and quantitative DNA methylation assay. Nucleic Acids Res 25: 2532-2534. (Pubitemid 27303718)
    • (1997) Nucleic Acids Research , vol.25 , Issue.12 , pp. 2532-2534
    • Xiong, Z.1    Laird, P.W.2
  • 149
    • 78651463452 scopus 로고    scopus 로고
    • Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases
    • Xu W, Yang H, Liu Y, Yang Y, Wang P, Kim S, et al, (2011) Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell 19: 17-30.
    • (2011) Cancer Cell , vol.19 , pp. 17-30
    • Xu, W.1    Yang, H.2    Liu, Y.3    Yang, Y.4    Wang, P.5    Kim, S.6
  • 151
    • 33847372445 scopus 로고    scopus 로고
    • Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor: Effects on gene expression and growth of glioma cells in vitro and in vivo
    • DOI 10.1158/1078-0432.CCR-06-1261
    • Yin D, Ong JM, Hu J, Desmond JC, Kawamata N, Konda BM, et al, (2007) Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor: effects on gene expression and growth of glioma cells in vitro and in vivo. Clin Cancer Res 13: 1045-1052. (Pubitemid 46340384)
    • (2007) Clinical Cancer Research , vol.13 , Issue.3 , pp. 1045-1052
    • Yin, D.1    Ong, J.M.2    Hu, J.3    Desmond, J.C.4    Kawamata, N.5    Konda, B.M.6    Black, K.L.7    Koeffler, H.P.8
  • 152
    • 79954416946 scopus 로고    scopus 로고
    • Readers of histone modifications
    • Yun M, Wu J, Workman JL, Li B, (2011) Readers of histone modifications. Cell Res 21: 564-578.
    • (2011) Cell Res , vol.21 , pp. 564-578
    • Yun, M.1    Wu, J.2    Workman, J.L.3    Li, B.4
  • 153
    • 64849098267 scopus 로고    scopus 로고
    • Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha
    • Zhao S, Lin Y, Xu W, Jiang W, Zha Z, Wang P, et al, (2009) Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science 324: 261-265.
    • (2009) Science , vol.324 , pp. 261-265
    • Zhao, S.1    Lin, Y.2    Xu, W.3    Jiang, W.4    Zha, Z.5    Wang, P.6
  • 154
    • 78649704843 scopus 로고    scopus 로고
    • Non-coding RNAs and their epigenetic regulatory mechanisms
    • Zhou H, Hu H, Lai M, (2010) Non-coding RNAs and their epigenetic regulatory mechanisms. Biol Cell 102: 645-655.
    • (2010) Biol Cell , vol.102 , pp. 645-655
    • Zhou, H.1    Hu, H.2    Lai, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.